Year |
Citation |
Score |
2013 |
Hulme EC. GPCR activation: a mutagenic spotlight on crystal structures. Trends in Pharmacological Sciences. 34: 67-84. PMID 23245528 DOI: 10.1016/J.Tips.2012.11.002 |
0.522 |
|
2011 |
Kaye RG, Saldanha JW, Lu ZL, Hulme EC. Helix 8 of the M1 muscarinic acetylcholine receptor: scanning mutagenesis delineates a G protein recognition site. Molecular Pharmacology. 79: 701-9. PMID 21247934 DOI: 10.1124/Mol.110.070177 |
0.566 |
|
2010 |
Hulme EC, Trevethick MA. Ligand binding assays at equilibrium: validation and interpretation. British Journal of Pharmacology. 161: 1219-37. PMID 20132208 DOI: 10.1111/J.1476-5381.2009.00604.X |
0.464 |
|
2009 |
Lebon G, Langmead CJ, Tehan BG, Hulme EC. Mutagenic mapping suggests a novel binding mode for selective agonists of M1 muscarinic acetylcholine receptors. Molecular Pharmacology. 75: 331-41. PMID 19001633 DOI: 10.1124/Mol.108.050963 |
0.547 |
|
2007 |
Goodwin JA, Hulme EC, Langmead CJ, Tehan BG. Roof and floor of the muscarinic binding pocket: variations in the binding modes of orthosteric ligands. Molecular Pharmacology. 72: 1484-96. PMID 17848601 DOI: 10.1124/Mol.107.038265 |
0.571 |
|
2007 |
Bee MS, Hulme EC. Functional analysis of transmembrane domain 2 of the M1 muscarinic acetylcholine receptor. The Journal of Biological Chemistry. 282: 32471-9. PMID 17823120 DOI: 10.1074/Jbc.M703909200 |
0.566 |
|
2007 |
Hulme EC, Bee MS, Goodwin JA. Phenotypic classification of mutants: a tool for understanding ligand binding and activation of muscarinic acetylcholine receptors. Biochemical Society Transactions. 35: 742-5. PMID 17635138 DOI: 10.1042/Bst0350742 |
0.608 |
|
2003 |
Hulme EC, Lu ZL, Saldanha JW, Bee MS. Structure and activation of muscarinic acetylcholine receptors. Biochemical Society Transactions. 31: 29-34. PMID 12546648 DOI: 10.1042/Bst0310029 |
0.63 |
|
2003 |
Hulme EC, Lu ZL, Bee MS. Scanning mutagenesis studies of the M1 muscarinic acetylcholine receptor. Receptors & Channels. 9: 215-228. DOI: 10.1080/10606820308261 |
0.637 |
|
2002 |
Lu ZL, Saldanha JW, Hulme EC. Seven-transmembrane receptors: crystals clarify. Trends in Pharmacological Sciences. 23: 140-6. PMID 11879682 DOI: 10.1016/S0165-6147(00)01973-8 |
0.554 |
|
2001 |
Lu ZL, Saldanha JW, Hulme EC. Transmembrane domains 4 and 7 of the M(1) muscarinic acetylcholine receptor are critical for ligand binding and the receptor activation switch. The Journal of Biological Chemistry. 276: 34098-104. PMID 11441014 DOI: 10.1074/Jbc.M104217200 |
0.633 |
|
2001 |
Hulme EC, Lu ZL, Bee M, Curtis CA, Saldanha J. The conformational switch in muscarinic acetylcholine receptors. Life Sciences. 68: 2495-500. PMID 11392618 DOI: 10.1016/S0024-3205(01)01044-X |
0.586 |
|
2000 |
Allman K, Page KM, Curtis CA, Hulme EC. Scanning mutagenesis identifies amino acid side chains in transmembrane domain 5 of the M(1) muscarinic receptor that participate in binding the acetyl methyl group of acetylcholine. Molecular Pharmacology. 58: 175-84. PMID 10860940 DOI: 10.1124/Mol.58.1.175 |
0.601 |
|
2000 |
Lu ZL, Hulme EC. A network of conserved intramolecular contacts defines the off-state of the transmembrane switch mechanism in a seven-transmembrane receptor. The Journal of Biological Chemistry. 275: 5682-6. PMID 10681552 DOI: 10.1074/Jbc.275.8.5682 |
0.546 |
|
2000 |
Lu Z-, Hulme EC. Functional Probing of Transmembrane Domain 7 of the M1 Muscarinic Acetylcholine Receptor by Alanine Scanning Mutagenesis Biochemical Society Transactions. 28. DOI: 10.1042/Bst028A268C |
0.519 |
|
1999 |
Ward SD, Curtis CA, Hulme EC. Alanine-scanning mutagenesis of transmembrane domain 6 of the M(1) muscarinic acetylcholine receptor suggests that Tyr381 plays key roles in receptor function. Molecular Pharmacology. 56: 1031-41. PMID 10531410 DOI: 10.1124/Mol.56.5.1031 |
0.62 |
|
1999 |
Hulme EC, Lu ZL, Ward SD, Allman K, Curtis CA. The conformational switch in 7-transmembrane receptors: the muscarinic receptor paradigm. European Journal of Pharmacology. 375: 247-60. PMID 10443581 DOI: 10.1016/S0014-2999(99)00297-6 |
0.526 |
|
1999 |
Lu ZL, Hulme EC. The functional topography of transmembrane domain 3 of the M1 muscarinic acetylcholine receptor, revealed by scanning mutagenesis. The Journal of Biological Chemistry. 274: 7309-15. PMID 10066794 DOI: 10.1074/Jbc.274.11.7309 |
0.587 |
|
1999 |
Hulme EC. Analysis of binding data. Methods in Molecular Biology (Clifton, N.J.). 106: 139-85. PMID 9921504 DOI: 10.1385/0-89603-530-1:139 |
0.361 |
|
1999 |
Ward SDC, Hulme EC. TYR381 in transmembrane domain six of the rat M1-muscarinic acetylcholine receptor plays a dual role in receptor function Life Sciences. 64: 564. DOI: 10.1016/S0024-3205(99)90483-6 |
0.575 |
|
1998 |
Hulme EC, Curtis CA. Purification of recombinant M1 muscarinic acetylcholine receptor. Biochemical Society Transactions. 26: S361. PMID 10047875 DOI: 10.1042/Bst026S361 |
0.557 |
|
1998 |
Hulme EC, Lu ZL. Scanning mutagenesis of transmembrane domain 3 of the M1 muscarinic acetylcholine receptor. Journal of Physiology, Paris. 92: 269-74. PMID 9789821 DOI: 10.1016/S0928-4257(98)80031-4 |
0.583 |
|
1997 |
Lu ZL, Curtis CA, Jones PG, Pavia J, Hulme EC. The role of the aspartate-arginine-tyrosine triad in the m1 muscarinic receptor: mutations of aspartate 122 and tyrosine 124 decrease receptor expression but do not abolish signaling. Molecular Pharmacology. 51: 234-41. PMID 9203628 DOI: 10.1124/Mol.51.2.234 |
0.611 |
|
1997 |
Allman K, Page KM, Hulme EC. Cysteine scanning mutagenesis of transmembrane domain V of the M1 muscarinic receptor Life Sciences. 60: 1177. DOI: 10.1016/S0024-3205(97)84326-3 |
0.501 |
|
1997 |
Curtis C, Hulme E. Over-expression and purification of engineered M1 muscarinic receptors Life Sciences. 60: 1176. DOI: 10.1016/S0024-3205(97)84325-1 |
0.373 |
|
1997 |
Lu Z, Jones PG, Curtis CAM, Hulme EC. Asp122 and Tyr124 in the M1 muscarinic receptor are critical for receptor folding but not for signalling Life Sciences. 60: 1176. DOI: 10.1016/S0024-3205(97)84324-X |
0.592 |
|
1995 |
Hulme EC, Curtis CA, Page KM, Jones PG. The role of charge interactions in muscarinic agonist binding, and receptor-response coupling. Life Sciences. 56: 891-8. PMID 10188790 DOI: 10.1016/0024-3205(95)00025-2 |
0.609 |
|
1995 |
Vasudevan S, Hulme EC, Bach M, Haase W, Pavia J, Reiländer H. Characterization of the rat m3 muscarinic acetylcholine receptor produced in insect cells infected with recombinant baculovirus. European Journal of Biochemistry / Febs. 227: 466-75. PMID 7851424 DOI: 10.1111/J.1432-1033.1995.Tb20411.X |
0.604 |
|
1995 |
Jones PG, Curtis CA, Hulme EC. The function of a highly-conserved arginine residue in activation of the muscarinic M1 receptor. European Journal of Pharmacology. 288: 251-7. PMID 7774669 DOI: 10.1016/0922-4106(95)90036-5 |
0.61 |
|
1995 |
Page KM, Curtis CA, Jones PG, Hulme EC. The functional role of the binding site aspartate in muscarinic acetylcholine receptors, probed by site-directed mutagenesis. European Journal of Pharmacology. 289: 429-37. PMID 7556411 DOI: 10.1016/0922-4106(95)90151-5 |
0.59 |
|
1994 |
Spalding T, Birdsall N, Curtis C, Hulme E. Acetylcholine mustard labels the binding site aspartate in muscarinic acetylcholine receptors. Journal of Biological Chemistry. 269: 4092-4097. DOI: 10.1016/s0021-9258(17)41747-9 |
0.527 |
|
1993 |
Hulme EC, Curtis CA, Page KM, Jones PG. Agonist activation of muscarinic acetylcholine receptors. Cellular Signalling. 5: 687-94. PMID 8130073 DOI: 10.1016/0898-6568(93)90030-P |
0.595 |
|
1993 |
Birdsall N, Spalding T, Corrie J, Curtis C, Hulme E. Studies on muscarinic receptors using nitrogen mustards Life Sciences. 52: 561. DOI: 10.1016/0024-3205(93)90338-4 |
0.604 |
|
1993 |
Jones PG, Curtis CAM, Hulme EC. Site-directed mutagenesis of a conserved arginine in the rat M1 receptor Life Sciences. 52: 560. DOI: 10.1016/0024-3205(93)90337-3 |
0.514 |
|
1993 |
Page KM, Curtis CAM, Hulme EC. Mutation of ASP to glu in the third transmembrane helix of the muscarinic receptors Life Sciences. 52: 560. DOI: 10.1016/0024-3205(93)90336-2 |
0.512 |
|
1991 |
Hulme EC, Kurtenbach E, Curtis CA. Muscarinic acetylcholine receptors: structure and function. Biochemical Society Transactions. 19: 133-8. PMID 1903735 DOI: 10.1042/Bst0190133 |
0.544 |
|
1991 |
Pedder EK, Eveleigh P, Poyner D, Hulme EC, Birdsall NJ. Modulation of the structure-binding relationships of antagonists for muscarinic acetylcholine receptor subtypes. British Journal of Pharmacology. 103: 1561-7. PMID 1884110 DOI: 10.1111/J.1476-5381.1991.Tb09827.X |
0.64 |
|
1990 |
Kurtenbach E, Pedder EK, Curtis CA, Hulme EC. The putative disulphide bond in muscarinic receptors. Biochemical Society Transactions. 18: 442-3. PMID 2373234 DOI: 10.1042/Bst0180442 |
0.518 |
|
1990 |
Hulme EC, Spalding TA, Curtis CA, Birdsall NJ, Corrie JE. Blockade of muscarinic receptors by alkylating agonist analogues. Biochemical Society Transactions. 18: 440-1. PMID 2373233 DOI: 10.1042/Bst0180440 |
0.311 |
|
1990 |
Hulme EC, Birdsall NJ, Buckley NJ. Muscarinic receptor subtypes. Annual Review of Pharmacology and Toxicology. 30: 633-73. PMID 2188581 DOI: 10.1146/annurev.pa.30.040190.003221 |
0.543 |
|
1990 |
Buckley NJ, Hulme EC, Birdsall NJ. Use of clonal cell lines in the analysis of neurotransmitter receptor mechanisms and function. Biochimica Et Biophysica Acta. 1055: 43-53. PMID 2171675 DOI: 10.1016/0167-4889(90)90089-V |
0.318 |
|
1990 |
Kurtenbach E, Curtis C, Pedder E, Aitken A, Harris A, Hulme E. Muscarinic acetylcholine receptors. Peptide sequencing identifies residues involved in antagonist binding and disulfide bond formation. Journal of Biological Chemistry. 265: 13702-13708. DOI: 10.1016/s0021-9258(18)77406-1 |
0.439 |
|
1989 |
Poyner D, Bansal S, Birdsall N, Curtis C, Hulme E, Pedder E. Binding properties of reconstituted muscarinic receptors in the absence of G-proteins Biochemical Society Transactions. 17: 768-769. DOI: 10.1042/Bst0170768 |
0.567 |
|
1989 |
Curtis CAM, Wheatley M, Bansal S, Birdsall NJM, Eveleigh P, Pedder EK, Poyner D, Hulme EC. Propylbenzilylcholine Mustard Labels an Acidic Residue in Transmembrane Helix 3 of the Muscarinic Receptor Journal of Biological Chemistry. 264: 489-495. DOI: 10.1016/S0021-9258(17)31284-X |
0.433 |
|
1988 |
Birdsall NJ, Curtis CA, Eveleigh P, Hulme EC, Pedder EK, Poyner D, Wheatley M. Muscarinic receptor subtypes and the selectivity of agonists and antagonists. Pharmacology. 37: 22-31. PMID 2467316 DOI: 10.1159/000138503 |
0.61 |
|
1987 |
Wheatley M, Birdsall NJ, Curtis C, Eveleigh P, Pedder EK, Poyner D, Stockton JM, Hulme EC. The structure and properties of the purified muscarinic acetylcholine receptor from rat forebrain. Biochemical Society Transactions. 15: 113-6. PMID 3556731 DOI: 10.1042/Bst0150113 |
0.36 |
|
1986 |
Birdsall NJ, Hulme EC, Keen M. The binding of pirenzepine to digitonin-solubilized muscarinic acetylcholine receptors from the rat myocardium. British Journal of Pharmacology. 87: 307-16. PMID 3754173 DOI: 10.1111/J.1476-5381.1986.Tb10819.X |
0.603 |
|
1986 |
Hulme E, Birdsall N. Distinctions in acetylcholine receptor activity. Nature. 323: 396-7. PMID 3093893 DOI: 10.1038/323396A0 |
0.58 |
|
1985 |
Berrie CP, Birdsall NJ, Dadi HK, Hulme EC, Morris RJ, Stockton JM, Wheatley M. Purification of the muscarinic acetylcholine receptor from rat forebrain. Biochemical Society Transactions. 13: 1101-3. PMID 4092829 DOI: 10.1042/Bst0131101 |
0.556 |
|
1985 |
Berrie CP, Birdsall NJ, Hulme EC, Keen M, Stockton JM. Solubilization and characterization of high and low affinity pirenzepine binding sites from rat cerebral cortex. British Journal of Pharmacology. 85: 697-703. PMID 4027484 DOI: 10.1111/J.1476-5381.1985.Tb10566.X |
0.505 |
|
1984 |
Berrie CP, Birdsall NJ, Hulme EC, Keen M, Stockton JM. Solubilization and characterization of guanine nucleotide-sensitive muscarinic agonist binding sites from rat myocardium. British Journal of Pharmacology. 82: 853-61. PMID 6478115 DOI: 10.1111/J.1476-5381.1984.Tb16482.X |
0.598 |
|
1984 |
Berrie CP, Birdsall NJ, Haga K, Haga T, Hulme EC. Hydrodynamic properties of muscarinic acetylcholine receptors solubilized from rat forebrain. British Journal of Pharmacology. 82: 839-51. PMID 6478114 DOI: 10.1111/J.1476-5381.1984.Tb16481.X |
0.632 |
|
1983 |
Hulme EC, Berrie CP, Haga T, Birdsall NJ, Burgen AS, Stockton J. Solubilisation and molecular characterisation of muscarinic acetylcholine receptors. Journal of Receptor Research. 3: 301-11. PMID 6854547 DOI: 10.3109/10799898309041943 |
0.477 |
|
1983 |
Birdsall NJ, Burgen AS, Hulme EC, Wong EH. The effect of p-chloromercuribenzoate on structure-binding relationships of muscarinic receptors in the rat cerebral cortex. British Journal of Pharmacology. 80: 197-204. PMID 6652370 DOI: 10.1111/J.1476-5381.1983.Tb11066.X |
0.551 |
|
1983 |
Birdsall NJ, Burgen AS, Hulme EC, Wong EH. The effects of p-chloromercuribenzoate on muscarinic receptors in the cerebral cortex. British Journal of Pharmacology. 80: 187-96. PMID 6652369 DOI: 10.1111/J.1476-5381.1983.Tb11065.X |
0.596 |
|
1983 |
Birdsall NJ, Hulme EC, Stockton JM. Muscarinic receptor subclasses: allosteric interactions. Cold Spring Harbor Symposia On Quantitative Biology. 48: 53-6. PMID 6586362 DOI: 10.1101/SQB.1983.048.01.007 |
0.496 |
|
1983 |
Hulme EC, Berrie CP, Birdsall NJ, Jameson M, Stockton JM. Regulation of muscarinic agonist binding by cations and guanine nucleotides. European Journal of Pharmacology. 94: 59-72. PMID 6418552 DOI: 10.1016/0014-2999(83)90442-9 |
0.477 |
|
1983 |
Birdsall NJ, Burgen AS, Hulme EC, Stockton JM, Zigmond MJ. The effect of McN-A-343 on muscarinic receptors in the cerebral cortex and heart. British Journal of Pharmacology. 78: 257-9. PMID 6187403 DOI: 10.1111/J.1476-5381.1983.Tb09388.X |
0.604 |
|
1983 |
Birdsall NJM, Hulme EC. Muscarinic receptor subclasses Trends in Pharmacological Sciences. 4: 459-463. DOI: 10.1016/0165-6147(83)90493-5 |
0.615 |
|
1982 |
De Belleroche J, Kilpatrick IC, Birdsall NJ, Hulme EC. Presynaptic muscarinic receptors on dopaminergic terminals in the nucleus accumbens. Brain Research. 234: 327-37. PMID 7059834 DOI: 10.1016/0006-8993(82)90873-3 |
0.539 |
|
1982 |
Bárány E, Berrie CP, Birdsall NJ, Burgen AS, Hulme EC. The binding properties of the muscarinic receptors of the cynomolgus monkey ciliary body and the response to the induction of agonist subsensitivity. British Journal of Pharmacology. 77: 731-9. PMID 6897523 DOI: 10.1111/J.1476-5381.1982.Tb09353.X |
0.632 |
|
1981 |
Coutinho-Netto J, Boyar M, Bradford HF, Birdsall NJ, Hulme EC. Acetylcholine release and muscarinic receptors in cortical synaptosomes from epileptic rats. Experimental Neurology. 74: 837-46. PMID 7308372 DOI: 10.1016/0014-4886(81)90256-9 |
0.369 |
|
1981 |
Hulme EC, Berrie CP, Birdsall NJ, Burgen AS. Two populations of binding sites for muscarinic antagonists in the rat heart. European Journal of Pharmacology. 73: 137-42. PMID 7308290 DOI: 10.1016/0014-2999(81)90085-6 |
0.525 |
|
1981 |
Abdul-Ghani AS, Boyar MM, Coutinho-Netto J, Bradford HF, Berrie CP, Hulme EC, Birdsall NJ. Effect of tityus toxin and sensory stimulation on muscarinic cholinergic receptors in vivo. Biochemical Pharmacology. 30: 2713-4. PMID 7295354 DOI: 10.1016/0006-2952(81)90543-8 |
0.503 |
|
1981 |
Kuhar MJ, Taylor N, Wamsley JK, Hulme EC, Birdsall NJ. Muscarinic cholinergic receptor localization in brain by electron microscopic autoradiography. Brain Research. 216: 1-9. PMID 7260602 DOI: 10.1016/0006-8993(81)91274-9 |
0.427 |
|
1980 |
Wells JW, Birdsall NJ, Burgen AS, Hulme EC. Competitive binding studies with multiple sites. Effects arising from depletion of the free radioligand. Biochimica Et Biophysica Acta. 632: 464-9. PMID 7417533 DOI: 10.1016/0304-4165(80)90242-1 |
0.468 |
|
1980 |
Kuhar MJ, Birdsall NJ, Burgen AS, Hulme EC. Ontogeny of muscarinic receptors in rat brain. Brain Research. 184: 375-83. PMID 7353163 DOI: 10.1016/0006-8993(80)90806-9 |
0.546 |
|
1980 |
Hammer R, Berrie CP, Birdsall NJ, Burgen AS, Hulme EC. Pirenzepine distinguishes between different subclasses of muscarinic receptors. Nature. 283: 90-2. PMID 7350532 DOI: 10.1038/283090A0 |
0.633 |
|
1980 |
Birdsall NJ, Burgen AS, Hulme EC. The binding properties of muscarinic receptors in the brain of the frog (R. temporaria). Brain Research. 184: 385-93. PMID 6965461 DOI: 10.1016/0006-8993(80)90807-0 |
0.543 |
|
1980 |
Birdsall NJ, Hulme EC, Burgen A. The character of the muscarinic receptors in different regions of the rat brain. Proceedings of the Royal Society of London. Series B, Biological Sciences. 207: 1-12. PMID 6102394 DOI: 10.1098/Rspb.1980.0011 |
0.631 |
|
1979 |
Luqmani YA, Bradford HF, Birdsall NJ, Hulme EC. Depolarisation-induced changes in muscarinic cholinergic receptors in synaptosomes. Nature. 277: 481-3. PMID 763331 DOI: 10.1038/277481A0 |
0.572 |
|
1979 |
Rotter A, Birdsall NJ, Burgen AS, Field PM, Hulme EC, Raisman G. Muscarinic receptors in the central nervous system of the rat. I. Technique for autoradiographic localization of the binding of [3H]propylbenzilylcholine mustard and its distribution in the forebrain. Brain Research. 180: 141-65. PMID 519514 DOI: 10.1016/0165-0173(79)90002-X |
0.488 |
|
1979 |
Birdsall NJ, Burgen AS, Hulme EC, Wells JW. The effects of ions on the binding of agonists and antagonists to muscarinic receptors. British Journal of Pharmacology. 67: 371-7. PMID 497538 DOI: 10.1111/J.1476-5381.1979.Tb08690.X |
0.49 |
|
1979 |
Barlow RB, Birdsall NJ, Hulme EC. Temperature coefficients of affinity constants for the binding of antagonists to muscarinic receptors in the rat cerebral cortex. British Journal of Pharmacology. 66: 587-90. PMID 465896 DOI: 10.1111/J.1476-5381.1979.Tb13698.X |
0.523 |
|
1979 |
Birdsall NJ, Burgen AS, Hulme EC. A study of the muscarinic receptor by gel electrophoresis. British Journal of Pharmacology. 66: 337-42. PMID 465889 DOI: 10.1111/J.1476-5381.1979.Tb13685.X |
0.418 |
|
1979 |
Berrie CP, Birdsall NJ, Burgen AS, Hulme EC. Guanine nucleotides modulate muscarinic receptor binding in the heart. Biochemical and Biophysical Research Communications. 87: 1000-5. PMID 465020 DOI: 10.1016/S0006-291X(79)80006-6 |
0.594 |
|
1977 |
Hulme EC. Interactions of alkaloids and peptides with opiate receptors. Biochemical Society Transactions. 5: 65-9. PMID 19325 DOI: 10.1042/Bst0050065 |
0.44 |
|
1976 |
Birdsall NJ, Hulme EC. C fragment of lipotropin has a high affinity for brain opiate receptors. Nature. 260: 793-5. PMID 1264258 DOI: 10.1038/260793a0 |
0.397 |
|
1976 |
Birdsall NJM, Burgen ASV, Hiley CR, Hulme EC. Binding of agonists and antagonists to muscarinic receptors Journal of Supramolecular Structure. 4: 367-371. PMID 1263513 DOI: 10.1002/Jss.400040307 |
0.63 |
|
1976 |
van Ree JM, de Wied D, Bradbury AF, Hulme EC, Smyth DC, Snell CR. Induction of tolerance to the analgesic action of lipotropin in C-fragment. Nature. 264: 792-4. PMID 1012322 DOI: 10.1038/264792A0 |
0.34 |
|
1976 |
Birdsall NJ, Hulme EC. Biochemical studies on muscarinic acetylcholine receptors. Journal of Neurochemistry. 27: 7-16. PMID 784913 DOI: 10.1111/j.1471-4159.1976.tb01536.x |
0.554 |
|
1976 |
Gispen WH, Wiegant VM, Bradbury AF, Hulme EC, Smyth DG, Snell CR, de Wied D. Induction of excessive grooming in the rat by fragments of lipotropin. Nature. 264: 794-5. PMID 189197 DOI: 10.1038/264794A0 |
0.408 |
|
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