| Year |
Citation |
Score |
| 2020 |
Ferguson L, Bhakta S, Fox KR, Wells G, Brucoli F. Synthesis and Biological Evaluation of a Novel C8-Pyrrolobenzodiazepine (PBD) Adenosine Conjugate. A Study on the Role of the PBD Ring in the Biological Activity of PBD-Conjugates. Molecules (Basel, Switzerland). 25. PMID 32164166 DOI: 10.3390/molecules25051243 |
0.327 |
|
| 2019 |
Ferguson L, Wells G, Bhakta S, Johnson J, Guzman J, Parish T, Prentice RA, Brucoli F. Integrated target-based and phenotypic screening approaches for the identification of anti-tubercular agents that bind to the mycobacterial adenylating enzyme MbtA. Chemmedchem. PMID 31454170 DOI: 10.1002/cmdc.201900217 |
0.304 |
|
| 2018 |
Shih PC, Yang Y, Parkinson GN, Wilderspin A, Wells G. A high-throughput fluorescence polarization assay for discovering inhibitors targeting the DNA-binding domain of signal transducer and activator of transcription 3 (STAT3). Oncotarget. 9: 32690-32701. PMID 30220975 DOI: 10.18632/Oncotarget.26013 |
0.706 |
|
| 2018 |
Gacesa R, Lawrence KP, Georgakopoulos ND, Yabe K, Dunlap WC, Barlow DJ, Wells G, Young AR, Long PF. The mycosporine-like amino acids porphyra-334 and shinorine are antioxidants and direct antagonists of Keap1-Nrf2 binding. Biochimie. PMID 30071261 DOI: 10.1016/J.Biochi.2018.07.020 |
0.646 |
|
| 2017 |
Gacesa R, Barlow D, Dunlap W, Georgakopoulos N, Wells G, Long P. Mycosporine-like amino acid activation of the Keap1-Nrf2 pathway Free Radical Biology and Medicine. 108. DOI: 10.1016/J.Freeradbiomed.2017.04.096 |
0.66 |
|
| 2016 |
Kaminska KK, Bertrand HC, Tajima H, Stafford WC, Cheng Q, Chen W, Wells G, Arner ES, Chew EH. Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads. Oncotarget. PMID 27244886 DOI: 10.18632/oncotarget.9579 |
0.348 |
|
| 2014 |
Schwalbe C, Wells G, Stevens M. Influence of steric crowding on hydrogen bonding in anti-cancer quinols Acta Crystallographica Section a Foundations and Advances. 70: C561-C561. DOI: 10.1107/S2053273314094388 |
0.486 |
|
| 2013 |
Brucoli F, Hawkins RM, James CH, Jackson PJ, Wells G, Jenkins TC, Ellis T, Kotecha M, Hochhauser D, Hartley JA, Howard PW, Thurston DE. An extended pyrrolobenzodiazepine-polyamide conjugate with selectivity for a DNA sequence containing the ICB2 transcription factor binding site. Journal of Medicinal Chemistry. 56: 6339-51. PMID 23889553 DOI: 10.1021/Jm4001852 |
0.678 |
|
| 2013 |
Hancock R, Schaap M, Pfister H, Wells G. Peptide inhibitors of the Keap1-Nrf2 protein-protein interaction with improved binding and cellular activity. Organic & Biomolecular Chemistry. 11: 3553-7. PMID 23615671 DOI: 10.1039/c3ob40249e |
0.328 |
|
| 2011 |
Brucoli F, Hawkins RM, James CH, Wells G, Jenkins TC, Ellis T, Hartley JA, Howard PW, Thurston DE. Novel C8-linked pyrrolobenzodiazepine (PBD)-heterocycle conjugates that recognize DNA sequences containing an inverted CCAAT box. Bioorganic & Medicinal Chemistry Letters. 21: 3780-3. PMID 21570842 DOI: 10.1016/J.Bmcl.2011.04.054 |
0.513 |
|
| 2011 |
König J, Wyllie S, Wells G, Stevens MF, Wyatt PG, Fairlamb AH. Antitumor quinol PMX464 is a cytocidal anti-trypanosomal inhibitor targeting trypanothione metabolism. The Journal of Biological Chemistry. 286: 8523-33. PMID 21212280 DOI: 10.1074/Jbc.M110.214833 |
0.597 |
|
| 2010 |
McCarroll AJ, Matthews CS, Wells G, Bradshaw TD, Stevens MF. Synthesis of antitumour (1H-1,2,3-triazol-4-yl)-4-hydroxycyclohexa-2,5-dien-1-ones by copper-catalysed Huisgen cycloadditions. Organic & Biomolecular Chemistry. 8: 2078-84. PMID 20401384 DOI: 10.1039/B920039H |
0.622 |
|
| 2010 |
Brucoli F, Hawkins R, Wells G, Jenkins T, Ellis T, Kotecha M, Hochhauser D, Hartley J, Howard P, Thurston D. 526 A potent PBD-heterocyclic polyamide conjugate targeting an ICB2 transcription factor binding site European Journal of Cancer Supplements. 8: 168. DOI: 10.1016/S1359-6349(10)72233-3 |
0.507 |
|
| 2008 |
Aiello S, Wells G, Stone EL, Kadri H, Bazzi R, Bell DR, Stevens MF, Matthews CS, Bradshaw TD, Westwell AD. Synthesis and biological properties of benzothiazole, benzoxazole, and chromen-4-one analogues of the potent antitumor agent 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (PMX 610, NSC 721648). Journal of Medicinal Chemistry. 51: 5135-9. PMID 18666770 DOI: 10.1021/Jm800418Z |
0.633 |
|
| 2008 |
Kotecha M, Kluza J, Wells G, O'Hare CC, Forni C, Mantovani R, Howard PW, Morris P, Thurston DE, Hartley JA, Hochhauser D. Inhibition of DNA binding of the NF-Y transcription factor by the pyrrolobenzodiazepine-polyamide conjugate GWL-78. Molecular Cancer Therapeutics. 7: 1319-28. PMID 18483319 DOI: 10.1158/1535-7163.Mct-07-0475 |
0.552 |
|
| 2008 |
Wells G, Suggitt M, Coffils M, Baig MA, Howard PW, Loadman PM, Hartley JA, Jenkins TC, Thurston DE. Fluorescent 7-diethylaminocoumarin pyrrolobenzodiazepine conjugates: synthesis, DNA interaction, cytotoxicity and differential cellular localization. Bioorganic & Medicinal Chemistry Letters. 18: 2147-51. PMID 18280154 DOI: 10.1016/J.Bmcl.2008.01.083 |
0.528 |
|
| 2006 |
Wells G, Martin CRH, Howard PW, Sands ZA, Laughton CA, Tiberghien A, Woo CK, Masterson LA, Stephenson MJ, Hartley JA, Jenkins TC, Shnyder SD, Loadman PM, Waring MJ, Thurston DE. Design, synthesis, and biophysical and biological evaluation of a series of pyrrolobenzodiazepine-poly(N-methylpyrrole) conjugates Journal of Medicinal Chemistry. 49: 5442-5461. PMID 16942018 DOI: 10.1021/Jm051199Z |
0.547 |
|
| 2006 |
Lion CJ, Matthews CS, Wells G, Bradshaw TD, Stevens MF, Westwell AD. Antitumour properties of fluorinated benzothiazole-substituted hydroxycyclohexa-2,5-dienones ('quinols'). Bioorganic & Medicinal Chemistry Letters. 16: 5005-8. PMID 16908135 DOI: 10.1016/J.Bmcl.2006.07.072 |
0.653 |
|
| 2006 |
Mortimer CG, Wells G, Crochard JP, Stone EL, Bradshaw TD, Stevens MF, Westwell AD. Antitumor benzothiazoles. 26.(1) 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a simple fluorinated 2-arylbenzothiazole, shows potent and selective inhibitory activity against lung, colon, and breast cancer cell lines. Journal of Medicinal Chemistry. 49: 179-85. PMID 16392802 DOI: 10.1021/Jm050942K |
0.639 |
|
| 2006 |
Shah M, Wells G, Bradshaw T, Laughton C, Stevens M, Westwell A. Antitubercular Properties of Substituted Hydroxycyclohexadienones Letters in Drug Design & Discovery. 3: 419-423. DOI: 10.2174/157018006777805486 |
0.507 |
|
| 2005 |
Bradshaw TD, Matthews CS, Cookson J, Chew EH, Shah M, Bailey K, Monks A, Harris E, Westwell AD, Wells G, Laughton CA, Stevens MF. Elucidation of thioredoxin as a molecular target for antitumor quinols. Cancer Research. 65: 3911-9. PMID 15867391 DOI: 10.1158/0008-5472.Can-04-4141 |
0.597 |
|
| 2005 |
Berry JM, Bradshaw TD, Fichtner I, Ren R, Schwalbe CH, Wells G, Chew EH, Stevens MF, Westwell AD. Quinols as novel therapeutic agents. 2.(1) 4-(1-Arylsulfonylindol-2-yl)-4-hydroxycyclohexa-2,5-dien-1-ones and related agents as potent and selective antitumor agents. Journal of Medicinal Chemistry. 48: 639-44. PMID 15658878 DOI: 10.1021/jm040859h |
0.634 |
|
| 2003 |
Wells G, Berry JM, Bradshaw TD, Burger AM, Seaton A, Wang B, Westwell AD, Stevens MF. 4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines. Journal of Medicinal Chemistry. 46: 532-41. PMID 12570375 DOI: 10.1021/Jm020984Y |
0.647 |
|
| 2000 |
Wells G, Seaton A, Stevens MF. Structural studies on bioactive compounds. 32. Oxidation of tyrphostin protein tyrosine kinase inhibitors with hypervalent iodine reagents. Journal of Medicinal Chemistry. 43: 1550-62. PMID 10780912 DOI: 10.1021/Jm990947F |
0.636 |
|
| 2000 |
Wells G, Bradshaw TD, Diana P, Seaton A, Shi DF, Westwell AD, Stevens MF. Antitumour benzothiazoles. Part 10: the synthesis and antitumour activity of benzothiazole substituted quinol derivatives. Bioorganic & Medicinal Chemistry Letters. 10: 513-5. PMID 10743960 DOI: 10.1016/S0960-894X(00)00027-5 |
0.65 |
|
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