Barry V. L. Potter, MA DPhil DSc FRSB FRSC MAE FMedSci - Publications

Affiliations: 
Max-Planck-Institute for Experimental Medicine, Göttingen, Germany 
 1984-1990 Biological Chemistry University of Leicester, Leicester, England, United Kingdom 
 1990- Medicine & Biological Chemistry University of Bath, Bath, England, United Kingdom 
 1998-2010 Sterix Ltd. 
 2015- Pharmacology University of Oxford, Oxford, United Kingdom 
Area:
medicinal chemistry, drug discovery, pharmacology
Website:
https://pharm.ox.ac.uk/research/potter-group-medicinal-biological-chemistry-drug-discovery

291 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Shen YC, Arellano-Garcia C, Menjivar RE, Jewett EM, Dohle W, Karchugina S, Chernoff J, Potter BVL, Barald KF. Nonsteroidal sulfamate derivatives as new therapeutic approaches for Neurofibromatosis 2 (NF2). Bmc Pharmacology & Toxicology. 20: 67. PMID 31730023 DOI: 10.1186/s40360-019-0369-8  0.48
2019 Riley AM, Wang H, Shears SB, Potter BVL. Synthesis of an α-phosphono-α,α-difluoroacetamide analogue of the diphosphoinositol pentakisphosphate 5-InsP. Medchemcomm. 10: 1165-1172. PMID 31391889 DOI: 10.1039/c9md00163h  0.84
2019 Dohle W, Su X, Mills SJ, Rossi AM, Taylor CW, Potter BVL. A synthetic cyclitol-nucleoside conjugate polyphosphate is a highly potent second messenger mimic. Chemical Science. 10: 5382-5390. PMID 31171961 DOI: 10.1039/C9SC00445A  0.92
2019 Baszczyňski O, Watt JM, Rozewitz MD, Guse AH, Fliegert R, Potter BVL. Synthesis of Terminal Ribose Analogues of Adenosine 5'-Diphosphate Ribose as Probes for the Transient Receptor Potential Cation Channel TRPM2. The Journal of Organic Chemistry. 84: 6143-6157. PMID 30978018 DOI: 10.1021/acs.joc.9b00338  0.64
2019 Kühn FJP, Watt JM, Potter BVL, Lückhoff A. Different substrate specificities of the two ADPR binding sites in TRPM2 channels of Nematostella vectensis and the role of IDPR. Scientific Reports. 9: 4985. PMID 30899048 DOI: 10.1038/s41598-019-41531-4  0.56
2019 Dohle W, Prota AE, Menchon G, Hamel E, Steinmetz MO, Potter BVL. Tetrahydroisoquinoline Sulfamates as Potent Microtubule Disruptors: Synthesis, Antiproliferative and Antitubulin Activity of Dichlorobenzyl-Based Derivatives, and a Tubulin Cocrystal Structure. Acs Omega. 4: 755-764. PMID 30775645 DOI: 10.1021/acsomega.8b02879  0.48
2019 Andring J, Dohle W, Tu C, Potter BVL, McKenna R. 3,17β-Bis-sulfamoyloxy-2-methoxyestra-1,3,5(10)-triene (STX140) and Non-Steroidal Sulfamate Derivatives Inhibit Carbonic Anhydrase IX: Structure-Activity Optimization for Isoform Selectivity. Journal of Medicinal Chemistry. PMID 30721041 DOI: 10.1021/acs.jmedchem.8b01990  0.48
2018 Brehm MA, Klemm U, Rehbach C, Erdmann N, Kolšek K, Lin H, Aponte-Santamaría C, Gräter F, Rauch BH, Riley AM, Mayr GW, Potter BVL, Windhorst S. Inositol hexakisphosphate increases the size of platelet aggregates. Biochemical Pharmacology. PMID 30557554 DOI: 10.1016/j.bcp.2018.12.011  0.84
2018 Zhang B, Watt JM, Cordiglieri C, Dammermann W, Mahon MF, Flügel A, Guse AH, Potter BVL. Small Molecule Antagonists of NAADP-Induced Ca Release in T-Lymphocytes Suggest Potential Therapeutic Agents for Autoimmune Disease. Scientific Reports. 8: 16775. PMID 30425261 DOI: 10.1038/s41598-018-34917-3  0.64
2018 Watt JM, Thomas MP, Potter BVL. Synthetic cADPR analogues may form only one of two possible conformational diastereoisomers. Scientific Reports. 8: 15268. PMID 30323284 DOI: 10.1038/s41598-018-33484-x  0.56
2018 Ganeshapillai D, Woo LWL, Thomas MP, Purohit A, Potter BVL. C-3- and C-4-Substituted Bicyclic Coumarin Sulfamates as Potent Steroid Sulfatase Inhibitors. Acs Omega. 3: 10748-10772. PMID 30320251 DOI: 10.1021/acsomega.8b01383  0.56
2018 Whitfield H, Gilmartin M, Baker K, Riley AM, Godage HY, Potter BVL, Hemmings AM, Brearley CA. A Fluorescent Probe Identifies Active Site Ligands of Inositol Pentakisphosphate 2-Kinase. Journal of Medicinal Chemistry. PMID 30160967 DOI: 10.1021/acs.jmedchem.8b01022  0.84
2018 Riley AM, Unterlass J, Konieczny V, Taylor CW, Helleday T, Potter BVL. A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate. Medchemcomm. 9: 1105-1113. PMID 30079174 DOI: 10.1039/C8MD00149A  0.84
2018 Whitfield H, Riley AM, Diogenous S, Godage HY, Potter BVL, Brearley CA. Simple synthesis of P-labelled inositol hexakisphosphates for study of phosphate transformations. Plant and Soil. 427: 149-161. PMID 29880988 DOI: 10.1007/s11104-017-3315-9  0.84
2018 Potter BVL. SULFATION PATHWAYS: Steroid sulphatase inhibition via aryl sulphamates: clinical progress, mechanism and future prospects. Journal of Molecular Endocrinology. 61: T233-T252. PMID 29618488 DOI: 10.1530/JME-18-0045  0.44
2017 Dohle W, Jourdan FL, Menchon G, Prota AE, Foster PA, Mannion P, Hamel E, Thomas MP, Kasprzyk PG, Ferrandis E, Steinmetz MO, Leese MP, Potter BVL. Quinazolinone-based Anticancer Agents: Synthesis, Anti-proliferative SAR, Anti-tubulin Activity and Tubulin Co-crystal Structure. Journal of Medicinal Chemistry. PMID 29227648 DOI: 10.1021/acs.jmedchem.7b01474  0.56
2017 Watt JM, Graeff R, Thomas MP, Potter BVL. Second messenger analogues highlight unexpected substrate sensitivity of CD38: total synthesis of the hybrid "L-cyclic inosine 5'-diphosphate ribose". Scientific Reports. 7: 16100. PMID 29170518 DOI: 10.1038/s41598-017-16388-0  0.56
2017 Mottinelli M, Leese MP, Potter BVL. Accessing simply-substituted 4-hydroxytetrahydroisoquinolines via Pomeranz-Fritsch-Bobbitt reaction with non-activated and moderately-activated systems. Beilstein Journal of Organic Chemistry. 13: 1871-1878. PMID 29062406 DOI: 10.3762/bjoc.13.182  0.4
2017 Kyratsous NI, Bauer IJ, Zhang G, Pesic M, Bartholomäus I, Mues M, Fang P, Wörner M, Everts S, Ellwart JW, Watt JM, Potter BVL, Hohlfeld R, Wekerle H, Kawakami N. Visualizing context-dependent calcium signaling in encephalitogenic T cells in vivo by two-photon microscopy. Proceedings of the National Academy of Sciences of the United States of America. PMID 28716943 DOI: 10.1073/pnas.1701806114  0.56
2017 Fliegert R, Bauche A, Wolf Pérez AM, Watt JM, Rozewitz MD, Winzer R, Janus M, Gu F, Rosche A, Harneit A, Flato M, Moreau C, Kirchberger T, Wolters V, Potter BVL, et al. 2'-Deoxyadenosine 5'-diphosphoribose is an endogenous TRPM2 superagonist. Nature Chemical Biology. PMID 28671679 DOI: 10.1038/nchembio.2415  0.64
2017 Fliegert R, Watt JM, Schöbel A, Rozewitz MD, Moreau C, Kirchberger T, Thomas MP, Sick W, Araujo AC, Harneit A, Potter BV, Guse AH. Ligand induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg 1433 and Tyr 1349. The Biochemical Journal. PMID 28515263 DOI: 10.1042/BCJ20170091  0.64
2016 Thomas MP, Erneux C, Potter BV. SHIP2: Structure, Function and Inhibition. Chembiochem : a European Journal of Chemical Biology. PMID 27907247 DOI: 10.1002/cbic.201600541  0.56
2016 Raimondi C, Calleja V, Ferro R, Fantin A, Riley AM, Potter BV, Brennan CH, Maffucci T, Larijani B, Falasca M. A Small Molecule Inhibitor of PDK1/PLCγ1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion. Scientific Reports. 6: 26142. PMID 27199173 DOI: 10.1038/srep26142  0.84
2016 Watson PJ, Millard CJ, Riley AM, Robertson NS, Wright LC, Godage HY, Cowley SM, Jamieson AG, Potter BV, Schwabe JW. Insights into the activation mechanism of class I HDAC complexes by inositol phosphates. Nature Communications. 7: 11262. PMID 27109927 DOI: 10.1038/ncomms11262  0.6
2016 Mills SJ, Silvander C, Cozier GE, Tresaugues L, Nordlund P, Potter BV. Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase INPP5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family. Biochemistry. PMID 26854536 DOI: 10.1021/acs.biochem.5b00838  0.6
2015 Nebel M, Zhang B, Odoardi F, Flügel A, Potter BV, Guse AH. Calcium Signalling Triggered by NAADP in T Cells Determines Cell Shape and Motility During Immune Synapse Formation. Messenger (Los Angeles, Calif. : Print). 4: 104-111. PMID 27747143 DOI: 10.1166/msr.2015.1045  0.64
2015 Thomas MP, Mills SJ, Potter BV. The "Other" Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances in myo-Inositol Chemistry). Angewandte Chemie (International Ed. in English). PMID 26694856 DOI: 10.1002/anie.201502227  0.6
2015 Shen YC, Upadhyayula R, Cevallos S, Messick RJ, Hsia T, Leese MP, Jewett DM, Ferrer-Torres D, Roth TM, Dohle W, Potter BV, Barald KF. Targeted NF1 cancer therapeutics with multiple modes of action: small molecule hormone-like agents resembling the natural anticancer metabolite, 2-methoxyoestradiol. British Journal of Cancer. 113: 1158-67. PMID 26461061 DOI: 10.1038/bjc.2015.345  0.6
2015 Stengel C, Newman SP, Leese MP, Thomas MP, Potter BV, Reed MJ, Purohit A, Foster PA. The In Vitro and In Vivo Activity of the Microtubule Disruptor STX140 Is Mediated by Hif-1 Alpha and CAIX Expression. Anticancer Research. 35: 5249-61. PMID 26408684  0.6
2015 Swarbrick JM, Riley AM, Mills SJ, Potter BVL. Designer small molecules to target calcium signalling Biochemical Society Transactions. 43: 417-425. PMID 26009185 DOI: 10.1042/BST20140293  0.6
2015 Thomas MP, Potter BV. Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Women's Health. Journal of Medicinal Chemistry. 58: 7634-58. PMID 25992880 DOI: 10.1021/acs.jmedchem.5b00386  0.56
2015 Thomas MP, Potter BV. Estrogen O-sulfamates and their analogues: Clinical steroid sulfatase inhibitors with broad potential. The Journal of Steroid Biochemistry and Molecular Biology. PMID 25843211 DOI: 10.1016/j.jsbmb.2015.03.012  0.6
2014 Tsuzuki T, Takano S, Sakaguchi N, Kudoh T, Murayama T, Sakurai T, Hashii M, Higashida H, Weber K, Guse AH, Kameda T, Hirokawa T, Kumaki Y, Arisawa M, Potter BV, et al. Design, Synthesis, and Chemical and Biological Properties of Cyclic ADP-4-Thioribose as a Stable Equivalent of Cyclic ADP-Ribose. Messenger (Los Angeles, Calif. : Print). 3: 35-51. PMID 27200225 DOI: 10.1166/msr.2014.1035  0.64
2014 Swarbrick JM, Graeff R, Zhang H, Thomas MP, Hao Q, Potter BV. Cyclic adenosine 5'-diphosphate ribose analogs without a "southern" ribose inhibit ADP-ribosyl cyclase-hydrolase CD38. Journal of Medicinal Chemistry. 57: 8517-29. PMID 25226087 DOI: 10.1021/jm501037u  0.6
2014 Stengel C, Newman SP, Day JM, Chander SK, Jourdan FL, Leese MP, Ferrandis E, Regis-Lydi S, Potter BV, Reed MJ, Purohit A, Foster PA. In vivo and in vitro properties of STX2484: a novel non-steroidal anti-cancer compound active in taxane-resistant breast cancer. British Journal of Cancer. 111: 300-8. PMID 24960406 DOI: 10.1038/bjc.2014.188  0.6
2014 Dohle W, Leese MP, Jourdan FL, Chapman CJ, Hamel E, Ferrandis E, Potter BV. Optimisation of tetrahydroisoquinoline-based chimeric microtubule disruptors. Chemmedchem. 9: 1783-93. PMID 24819406 DOI: 10.1002/cmdc.201402025  0.6
2014 Wang H, Godage HY, Riley AM, Weaver JD, Shears SB, Potter BV. Synthetic inositol phosphate analogs reveal that PPIP5K2 has a surface-mounted substrate capture site that is a target for drug discovery. Chemistry & Biology. 21: 689-99. PMID 24768307 DOI: 10.1016/j.chembiol.2014.03.009  0.6
2014 Leese MP, Jourdan FL, Major MR, Dohle W, Thomas MP, Hamel E, Ferrandis E, Mahon MF, Newman SP, Purohit A, Potter BV. Synthesis, anti-tubulin and antiproliferative SAR of steroidomimetic dihydroisoquinolinones. Chemmedchem. 9: 798-812. PMID 24596315 DOI: 10.1002/cmdc.201400017  0.6
2014 Pulloor NK, Nair S, Kostic AD, Bist P, Weaver JD, Riley AM, Tyagi R, Uchil PD, York JD, Snyder SH, García-Sastre A, Potter BV, Lin R, Shears SB, Xavier RJ, et al. Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon response. Plos Pathogens. 10: e1003981. PMID 24586175 DOI: 10.1371/journal.ppat.1003981  0.6
2014 Swarbrick JM, Graeff R, Garnham C, Thomas MP, Galione A, Potter BV. 'Click cyclic ADP-ribose': a neutral second messenger mimic. Chemical Communications (Cambridge, England). 50: 2458-61. PMID 24452494 DOI: 10.1039/c3cc49249d  0.6
2014 Dohle W, Leese MP, Jourdan FL, Major MR, Bai R, Hamel E, Ferrandis E, Kasprzyk PG, Fiore A, Newman SP, Purohit A, Potter BV. Synthesis, antitubulin, and antiproliferative SAR of C3/C1-substituted tetrahydroisoquinolines. Chemmedchem. 9: 350-70. PMID 24436228 DOI: 10.1002/cmdc.201300412  0.6
2014 Riley AM, Windhorst S, Lin HY, Potter BV. Cellular internalisation of an inositol phosphate visualised by using fluorescent InsP5. Chembiochem : a European Journal of Chemical Biology. 15: 57-67. PMID 24311195 DOI: 10.1002/cbic.201300583  0.84
2014 Thomas MP, Potter BV. The enzymes of human diphosphoinositol polyphosphate metabolism. The Febs Journal. 281: 14-33. PMID 24152294 DOI: 10.1111/febs.12575  0.56
2014 Leese MP, Jourdan FL, Major MR, Dohle W, Hamel E, Ferrandis E, Fiore A, Kasprzyk PG, Potter BV. Tetrahydroisoquinolinone-based steroidomimetic and chimeric microtubule disruptors. Chemmedchem. 9: 85-108, 1. PMID 24124095 DOI: 10.1002/cmdc.201300261  0.6
2013 Moreau C, Kirchberger T, Swarbrick JM, Bartlett SJ, Fliegert R, Yorgan T, Bauche A, Harneit A, Guse AH, Potter BV. Structure-activity relationship of adenosine 5'-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel: rational design of antagonists. Journal of Medicinal Chemistry. 56: 10079-102. PMID 24304219 DOI: 10.1021/jm401497a  0.6
2013 Moreau C, Liu Q, Graeff R, Wagner GK, Thomas MP, Swarbrick JM, Shuto S, Lee HC, Hao Q, Potter BV. CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5'-Diphosphate Ribose Template. Plos One. 8: e66247. PMID 23840430 DOI: 10.1371/journal.pone.0066247  0.6
2013 Tsuzuki T, Sakaguchi N, Kudoh T, Takano S, Uehara M, Murayama T, Sakurai T, Hashii M, Higashida H, Weber K, Guse AH, Kameda T, Hirokawa T, Kumaki Y, Potter BV, et al. Design and synthesis of cyclic ADP-4-thioribose as a stable equivalent of cyclic ADP-ribose, a calcium ion-mobilizing second messenger. Angewandte Chemie (International Ed. in English). 52: 6633-7. PMID 23670921 DOI: 10.1002/anie.201302098  0.6
2013 Nebel M, Schwoerer AP, Warszta D, Siebrands CC, Limbrock AC, Swarbrick JM, Fliegert R, Weber K, Bruhn S, Hohenegger M, Geisler A, Herich L, Schlegel S, Carrier L, Eschenhagen T, ... Potter BV, et al. Nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated calcium signaling and arrhythmias in the heart evoked by β-adrenergic stimulation. The Journal of Biological Chemistry. 288: 16017-30. PMID 23564460 DOI: 10.1074/jbc.M112.441246  0.64
2013 Woo LW, Wood PM, Bubert C, Thomas MP, Purohit A, Potter BV. Synthesis and structure-activity relationship studies of derivatives of the dual aromatase-sulfatase inhibitor 4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate. Chemmedchem. 8: 779-99. PMID 23495205 DOI: 10.1002/cmdc.201300015  0.6
2013 Saleem H, Tovey SC, Riley AM, Potter BV, Taylor CW. Stimulation of inositol 1,4,5-trisphosphate (IP3) receptor subtypes by adenophostin A and its analogues. Plos One. 8: e58027. PMID 23469136 DOI: 10.1371/journal.pone.0058027  0.6
2013 Godage HY, Riley AM, Woodman TJ, Thomas MP, Mahon MF, Potter BV. Regioselective opening of myo-inositol orthoesters: mechanism and synthetic utility. The Journal of Organic Chemistry. 78: 2275-88. PMID 23438216 DOI: 10.1021/jo3027774  0.84
2013 Saleem H, Tovey SC, Rahman T, Riley AM, Potter BV, Taylor CW. Stimulation of inositol 1,4,5-trisphosphate (IP3) receptor subtypes by analogues of IP3. Plos One. 8: e54877. PMID 23372785 DOI: 10.1371/journal.pone.0054877  0.6
2013 Thomas MP, Potter BVL. The structural biology of oestrogen metabolism Journal of Steroid Biochemistry and Molecular Biology. 137: 27-49. PMID 23291110 DOI: 10.1016/j.jsbmb.2012.12.014  0.6
2013 Khan SA, Rossi AM, Riley AM, Potter BV, Taylor CW. Subtype-selective regulation of IP(3) receptors by thimerosal via cysteine residues within the IP(3)-binding core and suppressor domain. The Biochemical Journal. 451: 177-84. PMID 23282150 DOI: 10.1042/BJ20121600  0.6
2013 Veiga N, Torres J, Macho I, Gómez K, Godage HY, Riley AM, Potter BV, González G, Kremer C. Inframolecular acid-base and coordination properties towards Na(+) and Mg(2+) of myo-inositol 1,3,4,5,6-pentakisphosphate: a structural approach to biologically relevant species. Dalton Transactions (Cambridge, England : 2003). 42: 6021-32. PMID 23183928 DOI: 10.1039/c2dt31807e  0.84
2013 Day JM, Foster PA, Tutill HJ, Schmidlin F, Sharland CM, Hargrave JD, Vicker N, Potter BV, Reed MJ, Purohit A. STX2171, a 17β-hydroxysteroid dehydrogenase type 3 inhibitor, is efficacious in vivo in a novel hormone-dependent prostate cancer model. Endocrine-Related Cancer. 20: 53-64. PMID 23132791 DOI: 10.1530/ERC-12-0231  0.6
2012 Mills SJ, Luyten T, Erneux C, Parys JB, Potter BV. Multivalent benzene polyphosphate derivatives are non-Ca(2+)-mobilizing Ins(1,4,5)P3 receptor antagonists. Messenger (Los Angeles, Calif. : Print). 1: 167-181. PMID 24749014 DOI: 10.1166/msr.2012.1016  0.92
2012 Grint T, Riley AM, Mills SJ, Potter BV, Safrany ST. Fibrinogen - a possible extracellular target for inositol phosphates. Messenger (Los Angeles, Calif. : Print). 1: 160-166. PMID 24749013 DOI: 10.1166/msr.2012.1014  0.92
2012 Su X, Halem HA, Thomas MP, Moutrille C, Culler MD, Vicker N, Potter BV. Adamantyl carboxamides and acetamides as potent human 11β-hydroxysteroid dehydrogenase type 1 inhibitors. Bioorganic & Medicinal Chemistry. 20: 6394-402. PMID 23040895 DOI: 10.1016/j.bmc.2012.08.056  0.6
2012 Riley AM, Wang H, Weaver JD, Shears SB, Potter BV. First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase. Chemical Communications (Cambridge, England). 48: 11292-4. PMID 23032903 DOI: 10.1039/c2cc36044f  0.6
2012 Turner BL, Cheesman AW, Godage HY, Riley AM, Potter BV. Determination of neo- and D-chiro-inositol hexakisphosphate in soils by solution 31P NMR spectroscopy. Environmental Science & Technology. 46: 4994-5002. PMID 22489788 DOI: 10.1021/es204446z  0.6
2012 Lawrence Woo LW, Leblond B, Purohit A, Potter BVL. Synthesis and evaluation of analogues of estrone-3-O-sulfamate as potent steroid sulfatase inhibitors Bioorganic and Medicinal Chemistry. 20: 2506-2519. PMID 22455789 DOI: 10.1016/j.bmc.2012.03.007  0.6
2012 Mills SJ, Persson C, Cozier G, Thomas MP, Trésaugues L, Erneux C, Riley AM, Nordlund P, Potter BV. A synthetic polyphosphoinositide headgroup surrogate in complex with SHIP2 provides a rationale for drug discovery. Acs Chemical Biology. 7: 822-8. PMID 22330088 DOI: 10.1021/cb200494d  0.6
2012 Swarbrick JM, Potter BV. Total synthesis of a cyclic adenosine 5'-diphosphate ribose receptor agonist. The Journal of Organic Chemistry. 77: 4191-7. PMID 22283398 DOI: 10.1021/jo202319f  0.6
2012 Moreau C, Kirchberger T, Zhang B, Thomas MP, Weber K, Guse AH, Potter BV. Aberrant cyclization affords a C-6 modified cyclic adenosine 5'-diphosphoribose analogue with biological activity in Jurkat T cells. Journal of Medicinal Chemistry. 55: 1478-89. PMID 22248391 DOI: 10.1021/jm201127y  0.64
2012 Sureshan KM, Riley AM, Thomas MP, Tovey SC, Taylor CW, Potter BV. Contribution of phosphates and adenine to the potency of adenophostins at the IP₃ receptor: synthesis of all possible bisphosphates of adenophostin A. Journal of Medicinal Chemistry. 55: 1706-20. PMID 22248345 DOI: 10.1021/jm201571p  0.6
2012 Leese MP, Jourdan F, Dohle W, Kimberley MR, Thomas MP, Bai R, Hamel E, Ferrandis E, Potter BV. Steroidomimetic Tetrahydroisoquinolines for the Design of New Microtubule Disruptors. Acs Medicinal Chemistry Letters. 3: 5-9. PMID 22247790 DOI: 10.1021/ml200232c  0.6
2011 Woo LW, Bubert C, Purohit A, Potter BV. Hybrid dual aromatase-steroid sulfatase inhibitors with exquisite picomolar inhibitory activity. Acs Medicinal Chemistry Letters. 2: 243-7. PMID 24900302 DOI: 10.1021/ml100273k  0.56
2011 Woo LW, Ganeshapillai D, Thomas MP, Sutcliffe OB, Malini B, Mahon MF, Purohit A, Potter BV. Structure-activity relationship for the first-in-class clinical steroid sulfatase inhibitor Irosustat (STX64, BN83495). Chemmedchem. 6: 2019-34. PMID 21990014 DOI: 10.1002/cmdc.201100288  0.6
2011 Su X, Pradaux-Caggiano F, Vicker N, Thomas MP, Halem H, Culler MD, Potter BV. Adamantyl ethanone pyridyl derivatives: potent and selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1. Chemmedchem. 6: 1616-29. PMID 21714097 DOI: 10.1002/cmdc.201100182  0.6
2011 Purohit A, Woo LW, Potter BV. Steroid sulfatase: a pivotal player in estrogen synthesis and metabolism. Molecular and Cellular Endocrinology. 340: 154-60. PMID 21693170 DOI: 10.1016/j.mce.2011.06.012  0.56
2011 Wood PM, Woo LW, Thomas MP, Mahon MF, Purohit A, Potter BV. Aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole and vorozole templates. Chemmedchem. 6: 1423-38. PMID 21608133 DOI: 10.1002/cmdc.201100145  0.56
2011 Su X, Vicker N, Thomas MP, Pradaux-Caggiano F, Halem H, Culler MD, Potter BV. Discovery of adamantyl heterocyclic ketones as potent 11β-hydroxysteroid dehydrogenase type 1 inhibitors. Chemmedchem. 6: 1439-51. PMID 21608132 DOI: 10.1002/cmdc.201100144  0.6
2011 Jourdan F, Leese MP, Dohle W, Ferrandis E, Newman SP, Chander S, Purohit A, Potter BV. Structure-activity relationships of C-17-substituted estratriene-3-O-sulfamates as anticancer agents. Journal of Medicinal Chemistry. 54: 4863-79. PMID 21604672 DOI: 10.1021/jm200483x  0.6
2011 Thomas MP, Potter BVL. Crystal structures of 11β-hydroxysteroid dehydrogenase type 1 and their use in drug discovery Future Medicinal Chemistry. 3: 367-390. PMID 21446847 DOI: 10.4155/fmc.10.282  0.6
2011 Woo LW, Purohit A, Potter BV. Development of steroid sulfatase inhibitors. Molecular and Cellular Endocrinology. 340: 175-85. PMID 21238537 DOI: 10.1016/j.mce.2010.12.035  0.56
2011 Moreau C, Ashamu GA, Bailey VC, Galione A, Guse AH, Potter BV. Synthesis of cyclic adenosine 5'-diphosphate ribose analogues: a C2'endo/syn "southern" ribose conformation underlies activity at the sea urchin cADPR receptor. Organic & Biomolecular Chemistry. 9: 278-90. PMID 20976353 DOI: 10.1039/c0ob00396d  0.64
2010 Rossi AM, Riley AM, Potter BV, Taylor CW. Adenophostins: High-Affinity Agonists of IP(3) Receptors. Current Topics in Membranes. 66: 209-33. PMID 22353482 DOI: 10.1016/S1063-5823(10)66010-3  0.6
2010 Wood PM, Woo LW, Labrosse JR, Thomas MP, Mahon MF, Chander SK, Purohit A, Reed MJ, Potter BV. Bicyclic derivatives of the potent dual aromatase-steroid sulfatase inhibitor 2-bromo-4-{[(4-cyanophenyl)(4h-1,2,4-triazol-4-yl)amino]methyl}phenylsulfamate: synthesis, SAR, crystal structure, and in vitro and in vivo activities. Chemmedchem. 5: 1577-93. PMID 20632362 DOI: 10.1002/cmdc.201000203  0.6
2010 Cordiglieri C, Odoardi F, Zhang B, Nebel M, Kawakami N, Klinkert WE, Lodygin D, Lühder F, Breunig E, Schild D, Ulaganathan VK, Dornmair K, Dammermann W, Potter BV, Guse AH, et al. Nicotinic acid adenine dinucleotide phosphate-mediated calcium signalling in effector T cells regulates autoimmunity of the central nervous system. Brain : a Journal of Neurology. 133: 1930-43. PMID 20519328 DOI: 10.1093/brain/awq135  0.6
2010 Su X, Pradaux-Caggiano F, Thomas MP, Szeto MW, Halem HA, Culler MD, Vicker N, Potter BV. Discovery of adamantyl ethanone derivatives as potent 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitors. Chemmedchem. 5: 1026-44. PMID 20486152 DOI: 10.1002/cmdc.201000081  0.6
2010 Leese MP, Jourdan F, Kimberley MR, Cozier GE, Thiyagarajan N, Stengel C, Regis-Lydi S, Foster PA, Newman SP, Acharya KR, Ferrandis E, Purohit A, Reed MJ, Potter BV. Chimeric microtubule disruptors. Chemical Communications (Cambridge, England). 46: 2907-9. PMID 20386818 DOI: 10.1039/c002558e  0.6
2010 Cozier GE, Leese MP, Lloyd MD, Baker MD, Thiyagarajan N, Acharya KR, Potter BV. Structures of human carbonic anhydrase II/inhibitor complexes reveal a second binding site for steroidal and nonsteroidal inhibitors. Biochemistry. 49: 3464-76. PMID 20297840 DOI: 10.1021/bi902178w  0.6
2010 Jourdan F, Leese MP, Dohle W, Hamel E, Ferrandis E, Newman SP, Purohit A, Reed MJ, Potter BV. Synthesis, antitubulin, and antiproliferative SAR of analogues of 2-methoxyestradiol-3,17-O,O-bis-sulfamate. Journal of Medicinal Chemistry. 53: 2942-51. PMID 20225862 DOI: 10.1021/jm9018806  0.6
2010 Ding Z, Rossi AM, Riley AM, Rahman T, Potter BV, Taylor CW. Binding of inositol 1,4,5-trisphosphate (IP3) and adenophostin A to the N-terminal region of the IP3 receptor: thermodynamic analysis using fluorescence polarization with a novel IP3 receptor ligand. Molecular Pharmacology. 77: 995-1004. PMID 20215561 DOI: 10.1124/mol.109.062596  0.6
2010 Woo LW, Jackson T, Putey A, Cozier G, Leonard P, Acharya KR, Chander SK, Purohit A, Reed MJ, Potter BV. Highly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl template. Journal of Medicinal Chemistry. 53: 2155-70. PMID 20148564 DOI: 10.1021/jm901705h  0.6
2010 Stengel C, Newman SP, Leese MP, Potter BVL, Reed MJ, Purohit A. Class III Β-tubulin expression and in vitro resistance to microtubule targeting agents British Journal of Cancer. 102: 316-324. PMID 20029418 DOI: 10.1038/sj.bjc.6605489  0.6
2009 Foster PA, Ho YT, Newman SP, Leese MP, Potter BV, Reed MJ, Purohit A. STX140 and STX641 cause apoptosis via the intrinsic mitochondrial pathway and down-regulate survivin and XIAP expression in ovarian and prostate cancer cells. Anticancer Research. 29: 3751-7. PMID 19846905  0.6
2009 Rossi AM, Riley AM, Tovey SC, Rahman T, Dellis O, Taylor EJ, Veresov VG, Potter BV, Taylor CW. Synthetic partial agonists reveal key steps in IP3 receptor activation. Nature Chemical Biology. 5: 631-9. PMID 19668195 DOI: 10.1038/nchembio.195  0.6
2009 Liu Q, Graeff R, Kriksunov IA, Jiang H, Zhang B, Oppenheimer N, Lin H, Potter BV, Lee HC, Hao Q. Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase. The Journal of Biological Chemistry. 284: 27637-45. PMID 19640846 DOI: 10.1074/jbc.M109.031005  0.6
2009 Dammermann W, Zhang B, Nebel M, Cordiglieri C, Odoardi F, Kirchberger T, Kawakami N, Dowden J, Schmid F, Dornmair K, Hohenegger M, Flügel A, Guse AH, Potter BV. NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP antagonist. Proceedings of the National Academy of Sciences of the United States of America. 106: 10678-83. PMID 19541638 DOI: 10.1073/pnas.0809997106  0.6
2009 Kirchberger T, Moreau C, Wagner GK, Fliegert R, Siebrands CC, Nebel M, Schmid F, Harneit A, Odoardi F, Flügel A, Potter BV, Guse AH. 8-Bromo-cyclic inosine diphosphoribose: towards a selective cyclic ADP-ribose agonist. The Biochemical Journal. 422: 139-49. PMID 19492987 DOI: 10.1042/BJ20082308  0.64
2009 Veiga N, Torres J, Godage HY, Riley AM, Domínguez S, Potter BV, Díaz A, Kremer C. The behaviour of inositol 1,3,4,5,6-pentakisphosphate in the presence of the major biological metal cations. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 14: 1001-13. PMID 19415348 DOI: 10.1007/s00775-009-0510-z  0.84
2009 Day JM, Purohit A, Tutill HJ, Foster PA, Woo LW, Potter BV, Reed MJ. The development of steroid sulfatase inhibitors for hormone-dependent cancer therapy. Annals of the New York Academy of Sciences. 1155: 80-7. PMID 19250195 DOI: 10.1111/j.1749-6632.2008.03677.x  0.6
2009 Sureshan KM, Riley AM, Rossi AM, Tovey SC, Dedos SG, Taylor CW, Potter BV. Activation of IP(3) receptors by synthetic bisphosphate ligands. Chemical Communications (Cambridge, England). 1204-6. PMID 19240874 DOI: 10.1039/b819328b  0.6
2009 Abbate S, Longhi G, Castiglioni E, Lebon F, Wood PM, Woo LW, Potter BV. Determination of the absolute configuration of aromatase and dual aromatase-sulfatase inhibitors by vibrational and electronic circular dichroism spectra analysis. Chirality. 21: 802-8. PMID 19161217 DOI: 10.1002/chir.20685  0.36
2009 Day JM, Foster PA, Tutill HJ, Newman SP, Ho YT, Leese MP, Potter BV, Reed MJ, Purohit A. BCRP expression does not result in resistance to STX140 in vivo, despite the increased expression of BCRP in A2780 cells in vitro after long-term STX140 exposure. British Journal of Cancer. 100: 476-86. PMID 19156141 DOI: 10.1038/sj.bjc.6604873  0.6
2009 Day JM, Tutill HJ, Foster PA, Bailey HV, Heaton WB, Sharland CM, Vicker N, Potter BV, Purohit A, Reed MJ. Development of hormone-dependent prostate cancer models for the evaluation of inhibitors of 17beta-hydroxysteroid dehydrogenase type 3. Molecular and Cellular Endocrinology. 301: 251-8. PMID 18786604 DOI: 10.1016/j.mce.2008.08.014  0.6
2009 Su X, Vicker N, Trusselle M, Halem H, Culler MD, Potter BV. Discovery of novel inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1. Molecular and Cellular Endocrinology. 301: 169-73. PMID 18775471 DOI: 10.1016/j.mce.2008.08.006  0.6
2009 Vicker N, Sharland CM, Heaton WB, Gonzalez AM, Bailey HV, Smith A, Springall JS, Day JM, Tutill HJ, Reed MJ, Purohit A, Potter BV. The design of novel 17beta-hydroxysteroid dehydrogenase type 3 inhibitors. Molecular and Cellular Endocrinology. 301: 259-65. PMID 18775469 DOI: 10.1016/j.mce.2008.08.005  0.6
2008 Fusi L, Purohit A, Brosens J, Woo LWL, Potter BVL, Reed MJ. Inhibition of steroid sulfatase activity in endometriotic implants by STX64 (667Coumate): A potential new therapy Thescientificworldjournal. 8: 1325-1327. PMID 19112542 DOI: 10.1100/tsw.2008.164  0.6
2008 Tagg SL, Foster PA, Leese MP, Potter BV, Reed MJ, Purohit A, Newman SP. 2-Methoxyoestradiol-3,17-O,O-bis-sulphamate and 2-deoxy-D-glucose in combination: a potential treatment for breast and prostate cancer. British Journal of Cancer. 99: 1842-8. PMID 18985042 DOI: 10.1038/sj.bjc.6604752  0.6
2008 Jourdan F, Bubert C, Leese MP, Smith A, Ferrandis E, Regis-Lydi S, Newman SP, Purohit A, Reed MJ, Potter BV. Effects of C-17 heterocyclic substituents on the anticancer activity of 2-ethylestra-1,3,5(10)-triene-3-O-sulfamates: synthesis, in vitro evaluation and computational modelling. Organic & Biomolecular Chemistry. 6: 4108-19. PMID 18972041 DOI: 10.1039/b810300c  0.6
2008 Foster PA, Chander SK, Newman SP, Woo LW, Sutcliffe OB, Bubert C, Zhou D, Chen S, Potter BV, Reed MJ, Purohit A. A new therapeutic strategy against hormone-dependent breast cancer: the preclinical development of a dual aromatase and sulfatase inhibitor. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 6469-77. PMID 18927286 DOI: 10.1158/1078-0432.CCR-08-1027  0.6
2008 Parsons MF, Foster PA, Chander SK, Jhalli R, Newman SP, Leese MP, Potter BV, Purohit A, Reed MJ. The in vivo properties of STX243: a potent angiogenesis inhibitor in breast cancer. British Journal of Cancer. 99: 1433-41. PMID 18841154 DOI: 10.1038/sj.bjc.6604707  0.6
2008 Bubert C, Woo LWL, Sutcliffe OB, Mahon MF, Chander SK, Purohit A, Reed MJ, Potter BVL. Synthesis of aromatase inhibitors and dual aromatase steroid sulfatase inhibitors by linking an arylsulfamate motif to 4-(4H-1,2,4-triazol-4-ylamino) benzonitrile: SAR, crystal structures, in vitro and in vivo activities Chemmedchem. 3: 1708-1730. PMID 18816537 DOI: 10.1002/cmdc.200800164  0.6
2008 Woo LW, Fischer DS, Sharland CM, Trusselle M, Foster PA, Chander SK, Di Fiore A, Supuran CT, De Simone G, Purohit A, Reed MJ, Potter BV. Anticancer steroid sulfatase inhibitors: synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography. Molecular Cancer Therapeutics. 7: 2435-44. PMID 18723489 DOI: 10.1158/1535-7163.MCT-08-0195  0.6
2008 Purohit A, Chander SK, Woo LWL, Parsons MFC, Jhalli R, Potter BVL, Reed MJ. Inhibition of steroid sulphatase activity via the percutaneous route: A new option for breast cancer therapy Anticancer Research. 28: 1517-1523. PMID 18630506  0.6
2008 Foster PA, Stengel C, Ali T, Leese MP, Potter BV, Reed MJ, Purohit A, Newman SP. A comparison of two orally bioavailable anti-cancer agents, IRC-110160 and STX140. Anticancer Research. 28: 1483-91. PMID 18630502  0.6
2008 Wood PM, Woo LW, Labrosse JR, Trusselle MN, Abbate S, Longhi G, Castiglioni E, Lebon F, Purohit A, Reed MJ, Potter BV. Chiral aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole template: synthesis, absolute configuration, and in vitro activity. Journal of Medicinal Chemistry. 51: 4226-38. PMID 18590272 DOI: 10.1021/jm800168s  0.6
2008 Mills SJ, Vandeput F, Trusselle MN, Safrany ST, Erneux C, Potter BVL. Benzene polyphosphates as tools for cell signalling: Inhibition of inositol 1,4,5-trisphosphate 5-phosphatase and interaction with the PH domain of protein kinase Bα Chembiochem. 9: 1757-1766. PMID 18574825 DOI: 10.1002/cbic.200800104  0.6
2008 Foster PA, Newman SP, Leese MP, Bernetiere S, Diolez C, Camara J, Hacher B, Baronnet MM, Ali T, Potter BV, Reed MJ, Purohit A. A new micronized formulation of 2-methoxyestradiol-bis-sulfamate (STX140) is therapeutically potent against breast cancer. Anticancer Research. 28: 577-81. PMID 18506995  0.6
2008 Foster PA, Woo LW, Potter BV, Reed MJ, Purohit A. The use of steroid sulfatase inhibitors as a novel therapeutic strategy against hormone-dependent endometrial cancer. Endocrinology. 149: 4035-42. PMID 18450955 DOI: 10.1210/en.2008-0223  0.6
2008 Su X, Vicker N, Potter BV. Inhibitors of 11beta-hydroxysteroid dehydrogenase type 1. Progress in Medicinal Chemistry. 46: 29-130. PMID 18381124 DOI: 10.1016/S0079-6468(07)00002-1  0.64
2008 Allan GM, Vicker N, Lawrence HR, Tutill HJ, Day JM, Huchet M, Ferrandis E, Reed MJ, Purohit A, Potter BV. Novel inhibitors of 17beta-hydroxysteroid dehydrogenase type 1: templates for design. Bioorganic & Medicinal Chemistry. 16: 4438-56. PMID 18329273 DOI: 10.1016/j.bmc.2008.02.059  0.6
2008 Zhang B, Wagner GK, Weber K, Garnham C, Morgan AJ, Galione A, Guse AH, Potter BV. 2'-deoxy cyclic adenosine 5'-diphosphate ribose derivatives: importance of the 2'-hydroxyl motif for the antagonistic activity of 8-substituted cADPR derivatives. Journal of Medicinal Chemistry. 51: 1623-36. PMID 18303825 DOI: 10.1021/jm7010386  0.64
2008 Bojarová P, Denehy E, Walker I, Loft K, De Souza DP, Woo LW, Potter BV, McConville MJ, Williams SJ. Direct evidence for ArO-S bond cleavage upon inactivation of Pseudomonas aeruginosa arylsulfatase by aryl sulfamates. Chembiochem : a European Journal of Chemical Biology. 9: 613-23. PMID 18288656 DOI: 10.1002/cbic.200700579  0.6
2008 Leese MP, Jourdan FL, Gaukroger K, Mahon MF, Newman SP, Foster PA, Stengel C, Regis-Lydi S, Ferrandis E, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BV. Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents. Journal of Medicinal Chemistry. 51: 1295-308. PMID 18260615 DOI: 10.1021/jm701319c  0.6
2008 Sureshan KM, Trusselle M, Tovey SC, Taylor CW, Potter BV. 2-Position base-modified analogues of adenophostin A as high-affinity agonists of the D-myo-inositol trisphosphate receptor: in vitro evaluation and molecular modeling. The Journal of Organic Chemistry. 73: 1682-92. PMID 18247493 DOI: 10.1021/jo702617c  0.6
2008 Jackson T, Woo LWL, Trusselle MN, Purohit A, Reed MJ, Potter BVL. Non-steroidal aromatase inhibitors based on a biphenyl scaffold: Synthesis, in vitro SAR, and molecular modelling Chemmedchem. 3: 603-618. PMID 18236493 DOI: 10.1002/cmdc.200700266  0.6
2008 Newman SP, Foster PA, Stengel C, Day JM, Ho YT, Judde JG, Lassalle M, Prevost G, Leese MP, Potter BV, Reed MJ, Purohit A. STX140 is efficacious in vitro and in vivo in taxane-resistant breast carcinoma cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 597-606. PMID 18223236 DOI: 10.1158/1078-0432.CCR-07-1717  0.6
2008 Day JM, Foster PA, Tutill HJ, Parsons MF, Newman SP, Chander SK, Allan GM, Lawrence HR, Vicker N, Potter BV, Reed MJ, Purohit A. 17beta-hydroxysteroid dehydrogenase Type 1, and not Type 12, is a target for endocrine therapy of hormone-dependent breast cancer. International Journal of Cancer. Journal International Du Cancer. 122: 1931-40. PMID 18183589 DOI: 10.1002/ijc.23350  0.6
2008 Purohit A, Fusi L, Brosens J, Woo LWL, Potter BVL, Reed MJ. Inhibition of steroid sulphatase activity in endometriotic implants by 667 COUMATE: A potential new therapy Human Reproduction. 23: 290-297. PMID 18056119 DOI: 10.1093/humrep/dem308  0.6
2008 Foster PA, Ho YT, Newman SP, Kasprzyk PG, Leese MP, Potter BV, Reed MJ, Purohit A. 2-MeOE2bisMATE and 2-EtE2bisMATE induce cell cycle arrest and apoptosis in breast cancer xenografts as shown by a novel ex vivo technique. Breast Cancer Research and Treatment. 111: 251-60. PMID 17957467 DOI: 10.1007/s10549-007-9791-5  0.6
2008 Foster PA, Chander SK, Parsons MF, Newman SP, Woo LW, Potter BV, Reed MJ, Purohit A. Efficacy of three potent steroid sulfatase inhibitors: pre-clinical investigations for their use in the treatment of hormone-dependent breast cancer. Breast Cancer Research and Treatment. 111: 129-38. PMID 17914670 DOI: 10.1007/s10549-007-9769-3  0.6
2007 Newman SP, Foster PA, Ho YT, Day JM, Raobaikady B, Kasprzyk PG, Leese MP, Potter BV, Reed MJ, Purohit A. The therapeutic potential of a series of orally bioavailable anti-angiogenic microtubule disruptors as therapy for hormone-independent prostate and breast cancers. British Journal of Cancer. 97: 1673-82. PMID 18026194 DOI: 10.1038/sj.bjc.6604100  0.6
2007 Jackson T, Woo LW, Trusselle MN, Chander SK, Purohit A, Reed MJ, Potter BV. Dual aromatase-sulfatase inhibitors based on the anastrozole template: synthesis, in vitro SAR, molecular modelling and in vivo activity. Organic & Biomolecular Chemistry. 5: 2940-52. PMID 17972413  0.56
2007 Jackson T, Woo LWL, Trusselle MN, Chander SK, Purohit A, Reed MJ, Potter BVL. Dual aromatase-sulfatase inhibitors based on the anastrozole template: Synthesis, in vitro SAR, molecular modelling and in vivo activity Organic and Biomolecular Chemistry. 5: 2940-2952. PMID 17728860 DOI: 10.1039/b707768h  0.6
2007 Bubert C, Leese MP, Mahon MF, Ferrandis E, Regis-Lydi S, Kasprzyk PG, Newman SP, Ho YT, Purohit A, Reed MJ, Potter BVL. 3,17-Disubstituted 2-alkylestra-1,3,5(10)-trien-3-ol derivatives: Synthesis, in vitro and in vivo anticancer activity Journal of Medicinal Chemistry. 50: 4431-4443. PMID 17696419 DOI: 10.1021/jm070405v  0.6
2007 Liu Q, Kriksunov IA, Moreau C, Graeff R, Potter BV, Lee HC, Hao Q. Catalysis-associated conformational changes revealed by human CD38 complexed with a non-hydrolyzable substrate analog. The Journal of Biological Chemistry. 282: 24825-32. PMID 17591784 DOI: 10.1074/jbc.M701653200  0.6
2007 Woo LW, Bubert C, Sutcliffe OB, Smith A, Chander SK, Mahon MF, Purohit A, Reed MJ, Potter BV. Dual aromatase-steroid sulfatase inhibitors. Journal of Medicinal Chemistry. 50: 3540-60. PMID 17580845 DOI: 10.1021/jm061462b  0.6
2007 Su X, Vicker N, Lawrence H, Smith A, Purohit A, Reed MJ, Potter BV. Inhibition of human and rat 11beta-hydroxysteroid dehydrogenase type 1 by 18beta-glycyrrhetinic acid derivatives. The Journal of Steroid Biochemistry and Molecular Biology. 104: 312-20. PMID 17493801 DOI: 10.1016/j.jsbmb.2007.03.019  0.6
2007 Vicker N, Su X, Ganeshapillai D, Smith A, Purohit A, Reed MJ, Potter BV. Novel non-steroidal inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1. The Journal of Steroid Biochemistry and Molecular Biology. 104: 123-9. PMID 17482805 DOI: 10.1016/j.jsbmb.2007.03.023  0.6
2007 Stanway SJ, Delavault P, Purohit A, Woo LWL, Thurieau C, Potter BVL, Reed MJ. Steroid sulfatase: A new target for the endocrine therapy of breast cancer Oncologist. 12: 370-374. PMID 17470679 DOI: 10.1634/theoncologist.12-4-370  0.6
2007 Mills SJ, Komander D, Trusselee MN, Safrany ST, van Aalten DMF, Potter BVL. Novel inositol phospholipid headgroup surrogate crystallized in the pleckstrin homology domain of protein kinase Bα Acs Chemical Biology. 2: 242-246. PMID 17432822 DOI: 10.1021/cb700019r  0.6
2007 Chander SK, Foster PA, Leese MP, Newman SP, Potter BV, Purohit A, Reed MJ. In vivo inhibition of angiogenesis by sulphamoylated derivatives of 2-methoxyoestradiol. British Journal of Cancer. 96: 1368-76. PMID 17426705 DOI: 10.1038/sj.bjc.6603727  0.6
2007 Vandeput F, Combettes L, Mills SJ, Backers K, Wohlkönig A, Parys JB, De Smedt H, Missiaen L, Dupont G, Potter BV, Erneux C. Biphenyl 2,3',4,5',6-pentakisphosphate, a novel inositol polyphosphate surrogate, modulates Ca2+ responses in rat hepatocytes. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 1481-91. PMID 17264160 DOI: 10.1096/fj.06-7691com  0.6
2006 Leese MP, Leblond B, Smith A, Newman SP, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BV. 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity. Journal of Medicinal Chemistry. 49: 7683-96. PMID 17181151 DOI: 10.1021/jm060705x  0.6
2006 Foster PA, Newman SP, Chander SK, Stengel C, Jhalli R, Woo LL, Potter BV, Reed MJ, Purohit A. In vivo efficacy of STX213, a second-generation steroid sulfatase inhibitor, for hormone-dependent breast cancer therapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 5543-9. PMID 17000691 DOI: 10.1158/1078-0432.CCR-06-0632  0.6
2006 Mochizuki T, Kondo Y, Abe H, Tovey SC, Dedos SG, Taylor CW, Paul M, Potter BV, Matsuda A, Shuto S. Synthesis of adenophostin A analogues conjugating an aromatic group at the 5'-position as potent IP3 receptor ligands. Journal of Medicinal Chemistry. 49: 5750-8. PMID 16970399 DOI: 10.1021/jm060310d  0.6
2006 Mills SJ, Dozol H, Vandeput F, Backers K, Woodman T, Erneux C, Spiess B, Potter BV. 3-hydroxybenzene 1,2,4-trisphosphate, a novel second messenger mimic and unusual substrate for type-I myo-inositol 1,4,5-trisphosphate 5-phosphatase: Synthesis and physicochemistry. Chembiochem : a European Journal of Chemical Biology. 7: 1696-706. PMID 16964627 DOI: 10.1002/cbic.200600125  0.92
2006 Moreau C, Wagner GK, Weber K, Guse AH, Potter BV. Structural determinants for N1/N7 cyclization of nicotinamide hypoxanthine 5'-dinucleotide (NHD+) derivatives by ADP-ribosyl cyclase from aplysia californica: Ca2+-mobilizing activity of 8-substituted cyclic inosine 5'-diphosphoribose analogues in T-lymphocytes. Journal of Medicinal Chemistry. 49: 5162-76. PMID 16913705 DOI: 10.1021/jm060275a  0.64
2006 Vicker N, Lawrence HR, Allan GM, Bubert C, Smith A, Tutill HJ, Purohit A, Day JM, Mahon MF, Reed MJ, Potter BV. Focused libraries of 16-substituted estrone derivatives and modified e-ring steroids: inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. Chemmedchem. 1: 464-81. PMID 16892382 DOI: 10.1002/cmdc.200500087  0.64
2006 Godage HY, Riley AM, Woodman TJ, Potter BV. Regioselective hydrolysis of myo-inositol 1,3,5-orthobenzoate via a 1,2-bridged 2'-phenyl-1',3'-dioxolan-2'-ylium ion provides a rapid route to the anticancer agent Ins(1,3,4,5,6)P5. Chemical Communications (Cambridge, England). 2989-91. PMID 16832513 DOI: 10.1039/b605392k  0.84
2006 Dowden J, Berridge G, Moreau C, Yamasaki M, Churchill GC, Potter BV, Galione A. Cell-permeant small-molecule modulators of NAADP-mediated Ca2+ release. Chemistry & Biology. 13: 659-65. PMID 16793523 DOI: 10.1016/j.chembiol.2006.05.005  0.6
2006 Sureshan KM, Trusselle M, Tovey SC, Taylor CW, Potter BV. Guanophostin A: Synthesis and evaluation of a high affinity agonist of the D-myo-inositol 1,4,5-trisphosphate receptor. Chemical Communications (Cambridge, England). 2015-7. PMID 16767260 DOI: 10.1039/b517911d  0.6
2006 Riley AM, Trusselle M, Kuad P, Borkovec M, Cho J, Choi JH, Qian X, Shears SB, Spiess B, Potter BV. scyllo-inositol pentakisphosphate as an analogue of myo-inositol 1,3,4,5,6-pentakisphosphate: chemical synthesis, physicochemistry and biological applications. Chembiochem : a European Journal of Chemical Biology. 7: 1114-22. PMID 16755629 DOI: 10.1002/cbic.200600037  0.6
2006 Mochizuki T, Kondo Y, Abe H, Taylor CW, Potter BV, Matsuda A, Shuto S. Design and synthesis of 5'-deoxy-5'-phenyladenophostin A, a highly potent IP3 receptor ligand. Organic Letters. 8: 1455-8. PMID 16562915 DOI: 10.1021/ol0602710  0.6
2006 Terauchi M, Abe H, Tovey SC, Dedos SG, Taylor CW, Paul M, Trusselle M, Potter BV, Matsuda A, Shuto S. A systematic study of C-glucoside trisphosphates as myo-inositol trisphosphate receptor ligands. Synthesis of beta-C-glucoside trisphosphates based on the conformational restriction strategy. Journal of Medicinal Chemistry. 49: 1900-9. PMID 16539376 DOI: 10.1021/jm051039n  0.6
2006 Stanway SJ, Purohit A, Woo LW, Sufi S, Vigushin D, Ward R, Wilson RH, Stanczyk FZ, Dobbs N, Kulinskaya E, Elliott M, Potter BV, Reed MJ, Coombes RC. Phase I study of STX 64 (667 Coumate) in breast cancer patients: the first study of a steroid sulfatase inhibitor. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 1585-92. PMID 16533785 DOI: 10.1158/1078-0432.CCR-05-1996  0.6
2006 Moreau C, Woodman TJ, Potter BV. Unusual entry to the novel 8-halo-N1-ribosyl hypoxanthine system by degradation of a cyclic adenosine-5'-diphosphate ribose analogue. Chemical Communications (Cambridge, England). 1127-9. PMID 16514461 DOI: 10.1039/b517916e  0.44
2006 Day JM, Tutill HJ, Newman SP, Purohit A, Lawrence HR, Vicker N, Potter BV, Reed MJ. 17Beta-hydroxysteroid dehydrogenase Type 1 and Type 2: association between mRNA expression and activity in cell lines. Molecular and Cellular Endocrinology. 248: 246-9. PMID 16490301 DOI: 10.1016/j.mce.2006.01.011  0.64
2006 Allan GM, Lawrence HR, Cornet J, Bubert C, Fischer DS, Vicker N, Smith A, Tutill HJ, Purohit A, Day JM, Mahon MF, Reed MJ, Potter BV. Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. Journal of Medicinal Chemistry. 49: 1325-45. PMID 16480268 DOI: 10.1021/jm050830t  0.64
2006 Purohit A, Tutill HJ, Day JM, Chander SK, Lawrence HR, Allan GM, Fischer DS, Vicker N, Newman SP, Potter BV, Reed MJ. The regulation and inhibition of 17beta-hydroxysteroid dehydrogenase in breast cancer. Molecular and Cellular Endocrinology. 248: 199-203. PMID 16414180 DOI: 10.1016/j.mce.2005.12.003  0.64
2006 Newman SP, Ireson CR, Tutill HJ, Day JM, Parsons MF, Leese MP, Potter BV, Reed MJ, Purohit A. The role of 17beta-hydroxysteroid dehydrogenases in modulating the activity of 2-methoxyestradiol in breast cancer cells. Cancer Research. 66: 324-30. PMID 16397246 DOI: 10.1158/0008-5472.CAN-05-2391  0.56
2006 Riley AM, Deleu S, Qian X, Mitchell J, Chung SK, Adelt S, Vogel G, Potter BV, Shears SB. On the contribution of stereochemistry to human ITPK1 specificity: Ins(1,4,5,6)P4 is not a physiologic substrate. Febs Letters. 580: 324-30. PMID 16376887 DOI: 10.1016/j.febslet.2005.12.016  0.84
2006 Allan GM, Bubert C, Vicker N, Smith A, Tutill HJ, Purohit A, Reed MJ, Potter BV. Novel, potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. Molecular and Cellular Endocrinology. 248: 204-7. PMID 16337736 DOI: 10.1016/j.mce.2005.10.021  0.64
2006 Su X, Vicker N, Ganeshapillai D, Smith A, Purohit A, Reed MJ, Potter BV. Benzothiazole derivatives as novel inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1. Molecular and Cellular Endocrinology. 248: 214-7. PMID 16325333 DOI: 10.1016/j.mce.2005.10.022  0.64
2005 Dowden J, Brown RS, Moreau C, Galione A, Potter BV. Chemical synthesis of the novel Ca2+ messenger NAADP. Nucleosides, Nucleotides & Nucleic Acids. 24: 513-8. PMID 16247981 DOI: 10.1081/NCN-200061786  0.6
2005 Maffucci T, Piccolo E, Cumashi A, Iezzi M, Riley AM, Saiardi A, Godage HY, Rossi C, Broggini M, Iacobelli S, Potter BV, Innocenti P, Falasca M. Inhibition of the phosphatidylinositol 3-kinase/Akt pathway by inositol pentakisphosphate results in antiangiogenic and antitumor effects. Cancer Research. 65: 8339-49. PMID 16166311 DOI: 10.1158/0008-5472.CAN-05-0121  0.84
2005 Fischer DS, Allan GM, Bubert C, Vicker N, Smith A, Tutill HJ, Purohit A, Wood L, Packham G, Mahon MF, Reed MJ, Potter BV. E-ring modified steroids as novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. Journal of Medicinal Chemistry. 48: 5749-70. PMID 16134943 DOI: 10.1021/jm050348a  0.64
2005 Leese MP, Hejaz HA, Mahon MF, Newman SP, Purohit A, Reed MJ, Potter BV. A-ring-substituted estrogen-3-O-sulfamates: potent multitargeted anticancer agents. Journal of Medicinal Chemistry. 48: 5243-56. PMID 16078843 DOI: 10.1021/jm050066a  0.56
2005 Poinas A, Backers K, Riley AM, Mills SJ, Moreau C, Potter BV, Erneux C. Interaction of the catalytic domain of inositol 1,4,5-trisphosphate 3-kinase A with inositol phosphate analogues. Chembiochem : a European Journal of Chemical Biology. 6: 1449-57. PMID 15997461 DOI: 10.1002/cbic.200400443  0.92
2005 Laude AJ, Tovey SC, Dedos SG, Potter BV, Lummis SC, Taylor CW. Rapid functional assays of recombinant IP3 receptors. Cell Calcium. 38: 45-51. PMID 15963563 DOI: 10.1016/j.ceca.2005.04.001  0.64
2005 Kudoh T, Fukuoka M, Ichikawa S, Murayama T, Ogawa Y, Hashii M, Higashida H, Kunerth S, Weber K, Guse AH, Potter BV, Matsuda A, Shuto S. Synthesis of stable and cell-type selective analogues of cyclic ADP-ribose, a Ca(2+)-mobilizing second messenger. Structure--activity relationship of the N1-ribose moiety. Journal of the American Chemical Society. 127: 8846-55. PMID 15954793 DOI: 10.1021/ja050732x  0.6
2005 Wagner GK, Guse AH, Potter BV. Rapid synthetic route toward structurally modified derivatives of cyclic adenosine 5'-diphosphate ribose. The Journal of Organic Chemistry. 70: 4810-9. PMID 15932322 DOI: 10.1021/jo050085s  0.64
2005 Raobaikady B, Reed MJ, Leese MP, Potter BV, Purohit A. Inhibition of MDA-MB-231 cell cycle progression and cell proliferation by C-2-substituted oestradiol mono- and bis-3-O-sulphamates. International Journal of Cancer. 117: 150-9. PMID 15880363 DOI: 10.1002/ijc.21066  0.56
2005 Lloyd MD, Thiyagarajan N, Ho YT, Woo LW, Sutcliffe OB, Purohit A, Reed MJ, Acharya KR, Potter BV. First crystal structures of human carbonic anhydrase II in complex with dual aromatase-steroid sulfatase inhibitors. Biochemistry. 44: 6858-66. PMID 15865431 DOI: 10.1021/bi047692e  0.56
2005 Leese MP, Leblond B, Newman SP, Purohit A, Reed MJ, Potter BV. Anti-cancer activities of novel D-ring modified 2-substituted estrogen-3-O-sulfamates. The Journal of Steroid Biochemistry and Molecular Biology. 94: 239-51. PMID 15862971 DOI: 10.1016/j.jsbmb.2005.01.005  0.56
2005 Raobaikady B, Day JM, Purohit A, Potter BV, Reed MJ. The nature of inhibition of steroid sulphatase activity by tibolone and its metabolites. The Journal of Steroid Biochemistry and Molecular Biology. 94: 229-37. PMID 15862970 DOI: 10.1016/j.jsbmb.2005.01.021  0.56
2005 Utsumi T, Leese MP, Chander SK, Gaukroger K, Purohit A, Newman SP, Potter BV, Reed MJ. The effects of 2-methoxyoestrogen sulphamates on the in vitro and in vivo proliferation of breast cancer cells. The Journal of Steroid Biochemistry and Molecular Biology. 94: 219-27. PMID 15862969 DOI: 10.1016/j.jsbmb.2005.01.022  0.56
2005 Purohit A, Ghilchik MW, Leese MP, Potter BV, Reed MJ. Regulation of aromatase activity by cytokines, PGE2 and 2-methoxyoestrone-3-O-sulphamate in fibroblasts derived from normal and malignant breast tissues. The Journal of Steroid Biochemistry and Molecular Biology. 94: 167-72. PMID 15862962 DOI: 10.1016/j.jsbmb.2005.01.015  0.56
2005 Wood PM, Woo LW, Humphreys A, Chander SK, Purohit A, Reed MJ, Potter BV. A letrozole-based dual aromatase-sulphatase inhibitor with in vivo activity. The Journal of Steroid Biochemistry and Molecular Biology. 94: 123-30. PMID 15862957 DOI: 10.1016/j.jsbmb.2004.12.028  0.56
2005 Lawrence HR, Vicker N, Allan GM, Smith A, Mahon MF, Tutill HJ, Purohit A, Reed MJ, Potter BV. Novel and potent 17beta-hydroxysteroid dehydrogenase type 1 inhibitors. Journal of Medicinal Chemistry. 48: 2759-62. PMID 15828812 DOI: 10.1021/jm049045r  0.64
2005 Borissow CN, Black SJ, Paul M, Tovey SC, Dedos SG, Taylor CW, Potter BV. Adenophostin A and analogues modified at the adenine moiety: synthesis, conformational analysis and biological activity. Organic & Biomolecular Chemistry. 3: 245-52. PMID 15632966 DOI: 10.1039/b415229h  0.64
2005 Reed MJ, Purohit A, Woo LW, Newman SP, Potter BV. Steroid sulfatase: molecular biology, regulation, and inhibition. Endocrine Reviews. 26: 171-202. PMID 15561802 DOI: 10.1210/er.2004-0003  0.56
2005 Lloyd MD, Pederick RL, Natesh R, Woo LW, Purohit A, Reed MJ, Acharya KR, Potter BV. Crystal structure of human carbonic anhydrase II at 1.95 A resolution in complex with 667-coumate, a novel anti-cancer agent. The Biochemical Journal. 385: 715-20. PMID 15453828 DOI: 10.1042/BJ20041037  0.6
2004 Dowden J, Moreau C, Brown RS, Berridge G, Galione A, Potter BV. Chemical synthesis of the second messenger nicotinic acid adenine dinucleotide phosphate by total synthesis of nicotinamide adenine dinucleotide phosphate. Angewandte Chemie (International Ed. in English). 43: 4637-40. PMID 15352191 DOI: 10.1002/anie.200460054  0.6
2004 Ireson CR, Chander SK, Purohit A, Parish DC, Woo LW, Potter BV, Reed MJ. Pharmacokinetics of the nonsteroidal steroid sulphatase inhibitor 667 COUMATE and its sequestration into red blood cells in rats. British Journal of Cancer. 91: 1399-404. PMID 15328524 DOI: 10.1038/sj.bjc.6602130  0.56
2004 Chander SK, Purohit A, Woo LW, Potter BV, Reed MJ. The role of steroid sulphatase in regulating the oestrogenicity of oestrogen sulphamates. Biochemical and Biophysical Research Communications. 322: 217-22. PMID 15313194 DOI: 10.1016/j.bbrc.2004.07.108  0.56
2004 Solyakov L, Cain K, Tracey BM, Jukes R, Riley AM, Potter BV, Tobin AB. Regulation of casein kinase-2 (CK2) activity by inositol phosphates. The Journal of Biological Chemistry. 279: 43403-10. PMID 15297462 DOI: 10.1074/jbc.M403239200  0.84
2004 Su X, Lawrence H, Ganeshapillai D, Cruttenden A, Purohit A, Reed MJ, Vicker N, Potter BV. Novel 18beta-glycyrrhetinic acid analogues as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenases. Bioorganic & Medicinal Chemistry. 12: 4439-57. PMID 15265495 DOI: 10.1016/j.bmc.2004.06.008  0.64
2004 Wood L, Leese MP, Mouzakiti A, Purohit A, Potter BV, Reed MJ, Packham G. 2-MeOE2bisMATE induces caspase-dependent apoptosis in CAL51 breast cancer cells and overcomes resistance to TRAIL via cooperative activation of caspases. Apoptosis : An International Journal On Programmed Cell Death. 9: 323-32. PMID 15258464  0.56
2004 Horne G, Maechling C, Fleig A, Hirata M, Penner R, Spiess B, Potter BV. D-6-Deoxy-myo-inositol 1,3,4,5-tetrakisphosphate, a mimic of d-myo-inositol 1,3,4,5-tetrakisphosphate: biological activity and pH-dependent conformational properties. Biochemical and Biophysical Research Communications. 320: 1262-70. PMID 15249226 DOI: 10.1016/j.bbrc.2004.06.079  0.6
2004 Gregory RB, Hughes R, Riley AM, Potter BV, Wilcox RA, Barritt GJ. Inositol trisphosphate analogues selective for types I and II inositol trisphosphate receptors exert differential effects on vasopressin-stimulated Ca2+ inflow and Ca2+ release from intracellular stores in rat hepatocytes. The Biochemical Journal. 381: 519-26. PMID 15169542 DOI: 10.1042/BJ20040637  0.84
2004 Vicker N, Su X, Lawrence H, Cruttenden A, Purohit A, Reed MJ, Potter BV. A novel 18 beta-glycyrrhetinic acid analogue as a potent and selective inhibitor of 11 beta-hydroxysteroid dehydrogenase 2. Bioorganic & Medicinal Chemistry Letters. 14: 3263-7. PMID 15149687 DOI: 10.1016/j.bmcl.2004.03.107  0.64
2004 Leese MP, Newman SP, Purohit A, Reed MJ, Potter BV. 2-Alkylsulfanyl estrogen derivatives: synthesis of a novel class of multi-targeted anti-tumour agents. Bioorganic & Medicinal Chemistry Letters. 14: 3135-8. PMID 15149660 DOI: 10.1016/j.bmcl.2004.04.027  0.56
2004 Riley AM, Dozol H, Spiess B, Potter BV. 2-O-(2-Aminoethyl)-myo-inositol 1,4,5-trisphosphate as a novel ligand for conjugation: physicochemical properties and synthesis of a new Ins(1,4,5)P(3) affinity matrix. Biochemical and Biophysical Research Communications. 318: 444-52. PMID 15120621 DOI: 10.1016/j.bbrc.2004.04.051  0.84
2004 Hejaz HA, Woo LW, Purohit A, Reed MJ, Potter BV. Synthesis, in vitro and in vivo activity of benzophenone-based inhibitors of steroid sulfatase. Bioorganic & Medicinal Chemistry. 12: 2759-72. PMID 15110857 DOI: 10.1016/j.bmc.2004.02.040  0.56
2004 Potter BV, Walseth TF. Medicinal chemistry and pharmacology of cyclic ADP-ribose. Current Molecular Medicine. 4: 303-11. PMID 15101687 DOI: 10.2174/1566524043360744  0.6
2004 Kunerth S, Langhorst MF, Schwarzmann N, Gu X, Huang L, Yang Z, Zhang L, Mills SJ, Zhang LH, Potter BV, Guse AH. Amplification and propagation of pacemaker Ca2+ signals by cyclic ADP-ribose and the type 3 ryanodine receptor in T cells. Journal of Cell Science. 117: 2141-9. PMID 15054112 DOI: 10.1242/jcs.01063  0.92
2004 Reed JE, Woo LW, Robinson JJ, Leblond B, Leese MP, Purohit A, Reed MJ, Potter BV. 2-difluoromethyloestrone 3-O-sulphamate, a highly potent steroid sulphatase inhibitor. Biochemical and Biophysical Research Communications. 317: 169-75. PMID 15047163 DOI: 10.1016/j.bbrc.2004.03.023  0.56
2004 Riley AM, Laude AJ, Taylor CW, Potter BV. Dimers of D-myo-inositol 1,4,5-trisphosphate: design, synthesis, and interaction with Ins(1,4,5)P3 receptors. Bioconjugate Chemistry. 15: 278-89. PMID 15025523 DOI: 10.1021/bc034214s  0.84
2004 Newman SP, Leese MP, Purohit A, James DR, Rennie CE, Potter BV, Reed MJ. Inhibition of in vitro angiogenesis by 2-methoxy- and 2-ethyl-estrogen sulfamates. International Journal of Cancer. Journal International Du Cancer. 109: 533-40. PMID 14991574 DOI: 10.1002/ijc.20045  0.56
2004 Ireson CR, Chander SK, Purohit A, Perera S, Newman SP, Parish D, Leese MP, Smith AC, Potter BV, Reed MJ. Pharmacokinetics and efficacy of 2-methoxyoestradiol and 2-methoxyoestradiol-bis-sulphamate in vivo in rodents. British Journal of Cancer. 90: 932-7. PMID 14970876 DOI: 10.1038/sj.bjc.6601591  0.56
2004 Piccolo E, Vignati S, Maffucci T, Innominato PF, Riley AM, Potter BV, Pandolfi PP, Broggini M, Iacobelli S, Innocenti P, Falasca M. Inositol pentakisphosphate promotes apoptosis through the PI 3-K/Akt pathway. Oncogene. 23: 1754-65. PMID 14755253 DOI: 10.1038/sj.onc.1207296  0.84
2004 Horne G, Mills SJ, Potter BV. First derivatives of myo-inositol 1,4,6-trisphosphate modified at positions 2 and 3: structural analogues of D-myo-inositol 1,4,5-trisphosphate. Carbohydrate Research. 339: 51-65. PMID 14659671 DOI: 10.1016/j.carres.2003.09.008  0.6
2003 Mills SJ, Riley AM, Liu C, Mahon MF, Potter BV. A definitive synthesis of D-myo-inositol 1,4,5,6-tetrakisphosphate and its enantiomer D-myo-inositol 3,4,5,6-tetrakisphosphate from a novel butane-2,3-diacetal-protected inositol. Chemistry (Weinheim An Der Bergstrasse, Germany). 9: 6207-14. PMID 14679531 DOI: 10.1002/chem.200305207  0.6
2003 Purohit A, Woo LW, Chander SK, Newman SP, Ireson C, Ho Y, Grasso A, Leese MP, Potter BV, Reed MJ. Steroid sulphatase inhibitors for breast cancer therapy. The Journal of Steroid Biochemistry and Molecular Biology. 86: 423-32. PMID 14623540 DOI: 10.1016/s0960-0760(03)00353-4  0.56
2003 Mills SJ, Backers K, Erneux C, Potter BV. Synthesis of D- and L-myo-inositol 1,2,4,6-tetrakisphosphate, regioisomers of myo-inositol 1,3,4,5 tetrakisphosphate: activity against Ins(1,4,5)P3 binding proteins. Organic & Biomolecular Chemistry. 1: 3546-56. PMID 14599016  0.92
2003 Rosenberg HJ, Riley AM, Laude AJ, Taylor CW, Potter BV. Synthesis and Ca2+-mobilizing activity of purine-modified mimics of adenophostin A: a model for the adenophostin-Ins(1,4,5)P3 receptor interaction. Journal of Medicinal Chemistry. 46: 4860-71. PMID 14584937 DOI: 10.1021/jm030883f  0.84
2003 Ho YT, Newman SP, Purohit A, Leese MP, Potter BV, Reed MJ. The effects of 2-methoxy oestrogens and their sulphamoylated derivatives in conjunction with TNF-alpha on endothelial and fibroblast cell growth, morphology and apoptosis. The Journal of Steroid Biochemistry and Molecular Biology. 86: 189-96. PMID 14568571 DOI: 10.1016/s0960-0760(03)00269-3  0.56
2003 Wagner GK, Riley AM, Rosenberg HJ, Taylor CW, Guse AH, Potter BV. Analogues of cyclic adenosine 5'-diphosphate ribose and adenophostin A, nucleotides in cellular signal transduction. Nucleic Acids Research. Supplement (2001). 1-2. PMID 14510350  0.84
2003 Mills SJ, Potter BV. Synthesis of potent Ins(1,4,5)P3 5-phosphatase inhibitors by modification of myo-inositol 1,3,4,6-tetrakisphosphate. Bioorganic & Medicinal Chemistry. 11: 4245-53. PMID 12951155 DOI: 10.1016/S0968-0896(03)00347-X  0.6
2003 Wagner GK, Black S, Guse AH, Potter BV. First enzymatic synthesis of an N1-cyclised cADPR (cyclic-ADP ribose) analogue with a hypoxanthine partial structure: discovery of a membrane permeant cADPR agonist. Chemical Communications (Cambridge, England). 1944-5. PMID 12932045  0.64
2003 Whitley P, Reaves BJ, Hashimoto M, Riley AM, Potter BV, Holman GD. Identification of mammalian Vps24p as an effector of phosphatidylinositol 3,5-bisphosphate-dependent endosome compartmentalization. The Journal of Biological Chemistry. 278: 38786-95. PMID 12878588 DOI: 10.1074/jbc.M306864200  0.84
2003 Woo LW, Sutcliffe OB, Bubert C, Grasso A, Chander SK, Purohit A, Reed MJ, Potter BV. First dual aromatase-steroid sulfatase inhibitors. Journal of Medicinal Chemistry. 46: 3193-6. PMID 12852749 DOI: 10.1021/jm034033b  0.56
2003 Ho YT, Purohit A, Vicker N, Newman SP, Robinson JJ, Leese MP, Ganeshapillai D, Woo LW, Potter BV, Reed MJ. Inhibition of carbonic anhydrase II by steroidal and non-steroidal sulphamates. Biochemical and Biophysical Research Communications. 305: 909-14. PMID 12767917  0.64
2003 Raobaikady B, Purohit A, Chander SK, Woo LW, Leese MP, Potter BV, Reed MJ. Inhibition of MCF-7 breast cancer cell proliferation and in vivo steroid sulphatase activity by 2-methoxyoestradiol-bis-sulphamate. The Journal of Steroid Biochemistry and Molecular Biology. 84: 351-8. PMID 12711022 DOI: 10.1016/s0960-0760(03)00049-9  0.56
2003 Fischer DS, Chander SK, Woo LW, Fenton JC, Purohit A, Reed MJ, Potter BV. Novel D-ring modified steroid derivatives as potent, non-estrogenic, steroid sulfatase inhibitors with in vivo activity. The Journal of Steroid Biochemistry and Molecular Biology. 84: 343-9. PMID 12711021 DOI: 10.1016/s0960-0760(03)00048-7  0.56
2003 Ireson CR, Parish D, Purohit A, Woo LW, Potter BV, Chander SK, Reed MJ. Development of a sensitive high-performance liquid chromatography method for the detection of 667 COUMATE in vivo. The Journal of Steroid Biochemistry and Molecular Biology. 84: 337-42. PMID 12711020 DOI: 10.1016/s0960-0760(03)00047-5  0.56
2003 Day JM, Newman SP, Comninos A, Solomon C, Purohit A, Leese MP, Potter BV, Reed MJ. The effects of 2-substituted oestrogen sulphamates on the growth of prostate and ovarian cancer cells. The Journal of Steroid Biochemistry and Molecular Biology. 84: 317-25. PMID 12711018  0.56
2003 Suzuki RN, Newman SP, Purohit A, Leese MP, Potter BV, Reed MJ. Growth inhibition of multi-drug-resistant breast cancer cells by 2-methoxyoestradiol-bis-sulphamate and 2-ethyloestradiol-bis-sulphamate. The Journal of Steroid Biochemistry and Molecular Biology. 84: 269-78. PMID 12711013 DOI: 10.1016/s0960-0760(03)00035-9  0.56
2003 Fischer DS, Woo LW, Mahon MF, Purohit A, Reed MJ, Potter BV. D-ring modified estrone derivatives as novel potent inhibitors of steroid sulfatase. Bioorganic & Medicinal Chemistry. 11: 1685-700. PMID 12659755 DOI: 10.1016/s0968-0896(03)00042-7  0.56
2003 Vicker N, Ho Y, Robinson J, Woo LL, Purohit A, Reed MJ, Potter BV. Docking studies of sulphamate inhibitors of estrone sulphatase in human carbonic anhydrase II. Bioorganic & Medicinal Chemistry Letters. 13: 863-5. PMID 12617909  0.64
2002 Howarth NM, Purohit A, Robinson JJ, Vicker N, Reed MJ, Potter BV. Estrone 3-sulfate mimics, inhibitors of estrone sulfatase activity: homology model construction and docking studies. Biochemistry. 41: 14801-14. PMID 12475228  0.64
2002 Mills SJ, Liu C, Potter BV. Synthesis of D- and L-myo-inositol 2,4,5-trisphosphate and trisphosphorothioate: structural analogues of D-myo-inositol 1,4,5-trisphosphate. Carbohydrate Research. 337: 1795-801. PMID 12431881 DOI: 10.1016/S0008-6215(02)00289-6  0.6
2002 Riley AM, Morris SA, Nerou EP, Correa V, Potter BV, Taylor CW. Interactions of inositol 1,4,5-trisphosphate (IP(3)) receptors with synthetic poly(ethylene glycol)-linked dimers of IP(3) suggest close spacing of the IP(3)-binding sites. The Journal of Biological Chemistry. 277: 40290-5. PMID 12183463 DOI: 10.1074/jbc.M206925200  0.84
2002 Morris SA, Nerou EP, Riley AM, Potter BV, Taylor CW. Determinants of adenophostin A binding to inositol trisphosphate receptors. The Biochemical Journal. 367: 113-20. PMID 12088506 DOI: 10.1042/BJ20020675  0.84
2002 Riley AM, Jenkins DJ, Marwood RD, Potter BVL. Synthesis of glucopyranoside-based ligands for D-myo-inositol 1,4,5-trisphosphate receptors Carbohydrate Research. 337: 1067-1082. PMID 12062522 DOI: 10.1016/S0008-6215(02)00103-9  0.6
2002 Guse AH, Cakir-Kiefer C, Fukuoka M, Shuto S, Weber K, Bailey VC, Matsuda A, Mayr GW, Oppenheimer N, Schuber F, Potter BV. Novel hydrolysis-resistant analogues of cyclic ADP-ribose: modification of the "northern" ribose and calcium release activity. Biochemistry. 41: 6744-51. PMID 12022878  0.64
2002 Ho MW, Yang X, Carew MA, Zhang T, Hua L, Kwon YU, Chung SK, Adelt S, Vogel G, Riley AM, Potter BV, Shears SB. Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase. Current Biology : Cb. 12: 477-82. PMID 11909533  0.84
2002 Parekh AB, Riley AM, Potter BV. Adenophostin A and ribophostin, but not inositol 1,4,5-trisphosphate or manno-adenophostin, activate the Ca2+ release-activated Ca2+ current, I(CRAC), in weak intracellular Ca2+ buffer. The Biochemical Journal. 361: 133-41. PMID 11742538 DOI: 10.1042/0264-6021:3610133  0.84
2001 Wood L, Leese MR, Leblond B, Woo LW, Ganeshapillai D, Purohit A, Reed MJ, Potter BV, Packham G. Inhibition of superoxide dismutase by 2-methoxyoestradiol analogues and oestrogen derivatives: structure-activity relationships. Anti-Cancer Drug Design. 16: 209-15. PMID 12049479  0.56
2001 Rosenberg HJ, Riley AM, Marwood RD, Correa V, Taylor CW, Potter BVL. Xylopyranoside-based agonists of D-myo-inositol 1,4,5-trisphosphate receptors: synthesis and effect of stereochemistry on biological activity. Carbohydrate Research. 332: 53-66. PMID 11403088  0.4
2001 Ukhanov K, Mills SJ, Potter BV, Walz B. InsP(3)-induced Ca(2+) release in permeabilized invertebrate photoreceptors: a link between phototransduction and Ca(2+) stores. Cell Calcium. 29: 335-45. PMID 11292390 DOI: 10.1054/ceca.2001.0195  0.6
2001 Purohit A, Woo LW, Barrow D, Hejaz HA, Nicholson RI, Potter BV, Reed MJ. Non-steroidal and steroidal sulfamates: new drugs for cancer therapy. Molecular and Cellular Endocrinology. 171: 129-35. PMID 11165021 DOI: 10.1016/s0303-7207(00)00428-7  0.56
2000 Newman SP, Purohit A, Ghilchik MW, Potter BV, Reed MJ. Regulation of steroid sulphatase expression and activity in breast cancer. The Journal of Steroid Biochemistry and Molecular Biology. 75: 259-64. PMID 11282280 DOI: 10.1016/s0960-0760(00)00177-1  0.56
2000 Malini B, Purohit A, Ganeshapillai D, Woo LW, Potter BV, Reed MJ. Inhibition of steroid sulphatase activity by tricyclic coumarin sulphamates. The Journal of Steroid Biochemistry and Molecular Biology. 75: 253-8. PMID 11282279 DOI: 10.1016/s0960-0760(00)00178-3  0.56
2000 Bonser J, Walker J, Purohit A, Reed MJ, Potter BV, Willis DS, Franks S, Mason HD. Human granulosa cells are a site of sulphatase activity and are able to utilize dehydroepiandrosterone sulphate as a precursor for oestradiol production. The Journal of Endocrinology. 167: 465-71. PMID 11115773 DOI: 10.1677/joe.0.1670465  0.6
2000 Woo LL, Purohit A, Malini B, Reed MJ, Potter BV. Potent active site-directed inhibition of steroid sulphatase by tricyclic coumarin-based sulphamates. Chemistry & Biology. 7: 773-91. PMID 11033081  0.56
2000 Purohit A, Woo LW, Potter BV, Reed MJ. In vivo inhibition of estrone sulfatase activity and growth of nitrosomethylurea-induced mammary tumors by 667 COUMATE. Cancer Research. 60: 3394-6. PMID 10910045  0.56
2000 Singh A, Purohit A, Hejaz HA, Potter BV, Reed MJ. Inhibition of deoxyglucose uptake in MCF-7 breast cancer cells by 2-methoxyestrone and 2-methoxyestrone-3-O-sulfamate. Molecular and Cellular Endocrinology. 160: 61-6. PMID 10715539 DOI: 10.1016/s0303-7207(99)00256-7  0.56
2000 Purohit A, Hejaz HA, Walden L, MacCarthy-Morrogh L, Packham G, Potter BV, Reed MJ. The effect of 2-methoxyoestrone-3-O-sulphamate on the growth of breast cancer cells and induced mammary tumours. International Journal of Cancer. 85: 584-9. PMID 10699934 DOI: 10.1002/(SICI)1097-0215(20000215)85:4<584::AID-IJC22>3.0.CO;2-Q  0.56
2000 Murphy CT, Riley AM, Mills SJ, Lindley CJ, Potter BV, Westwick J. myo-inositol 1,4,6-trisphosphorothioate and myo-inositol 1,3, 6-trisphosphorothioate: partial agonists with very low intrinsic activity at the platelet myo-inositol 1,4,5-trisphosphate receptor. Molecular Pharmacology. 57: 595-601. PMID 10692501  0.6
1999 Hejaz HA, Purohit A, Mahon MF, Reed MJ, Potter BV. Synthesis and biological activity of the superestrogen (E)-17-oximino-3-O-sulfamoyl-1,3,5(10)-estratriene: x-ray crystal structure of (E)-17-oximino-3-hydroxy-1,3,5(10)-estratriene. Journal of Medicinal Chemistry. 42: 3188-92. PMID 10447965 DOI: 10.1021/jm980717l  0.56
1999 Purohit A, Hejaz HA, Woo LW, van Strien AE, Potter BV, Reed MJ. Recent advances in the development of steroid sulphatase inhibitors. The Journal of Steroid Biochemistry and Molecular Biology. 69: 227-38. PMID 10418996 DOI: 10.1016/s0960-0760(99)00039-4  0.56
1999 Liu C, Davis RJ, Nahorski SR, Ballereau S, Spiess B, Potter BV. Synthesis, calcium mobilizing, and physicochemical properties of D-chiro-inositol 1,3,4,6-tetrakisphosphate, a novel and potent ligand at the D-myo-inositol 1,4,5-trisphosphate receptor. Journal of Medicinal Chemistry. 42: 1991-8. PMID 10354407 DOI: 10.1021/jm980733i  0.52
1999 Davies AR, Hardick DJ, Blagbrough IS, Potter BV, Wolstenholme AJ, Wonnacott S. Characterisation of the binding of [3H]methyllycaconitine: a new radioligand for labelling alpha 7-type neuronal nicotinic acetylcholine receptors. Neuropharmacology. 38: 679-90. PMID 10340305 DOI: 10.1016/S0028-3908(98)00221-4  0.6
1999 Hirst PH, Riley AM, Mills SJ, Spiers ID, Poyner DR, Freeman S, Potter BV, Smith AW. Inositol polyphosphate-mediated iron transport in Pseudomonas aeruginosa. Journal of Applied Microbiology. 86: 537-43. PMID 10196759  0.92
1998 Purohit A, Vernon KA, Hummelinck AE, Woo LW, Hejaz HA, Potter BV, Reed MJ. The development of A-ring modified analogues of oestrone-3-O-sulphamate as potent steroid sulphatase inhibitors with reduced oestrogenicity. The Journal of Steroid Biochemistry and Molecular Biology. 64: 269-75. PMID 9618028 DOI: 10.1016/s0960-0760(97)00196-9  0.56
1998 Purohit A, Potter BV, Parker MG, Reed MJ. Steroid sulphatase: expression, isolation and inhibition for active-site identification studies. Chemico-Biological Interactions. 109: 183-93. PMID 9566745 DOI: 10.1016/s0009-2797(97)00132-4  0.56
1998 Woo LW, Howarth NM, Purohit A, Hejaz HA, Reed MJ, Potter BV. Steroidal and nonsteroidal sulfamates as potent inhibitors of steroid sulfatase. Journal of Medicinal Chemistry. 41: 1068-83. PMID 9544207 DOI: 10.1021/jm970527v  0.56
1997 Murphy CT, Riley AM, Lindley CJ, Jenkins DJ, Westwick J, Potter BVL. Structural analogues of D-myo-inositol-1,4,5-trisphosphate and adenophostin A: Recognition by cerebellar and platelet inositol-1,4,5- trisphosphate receptors Molecular Pharmacology. 52: 741-748. PMID 9380038  0.6
1997 Hirata M, Takeuchi H, Riley AM, Mills SJ, Watanabe Y, Potter BV. Inositol 1,4,5-trisphosphate receptor subtypes differentially recognize regioisomers of D-myo-inositol 1,4,5-trisphosphate. The Biochemical Journal. 328: 93-8. PMID 9359838  0.6
1996 Mills SJ, Potter BV. Synthesis of D- and L-myo-Inositol 1,4,6-Trisphosphate, Regioisomers of a Ubiquitous Second Messenger. The Journal of Organic Chemistry. 61: 8980-8987. PMID 11667881  0.92
1996 Murphy CT, Bullock AJ, Lindley CJ, Mills SJ, Riley AM, Potter BV, Westwick J. Enantiomers of myo-inositol-1,3,4-trisphosphate and myo-inositol-1,4,6 -trisphosphate: stereospecific recognition by cerebellar and platelet myo-inositol-1,4,5-trisphosphate receptors. Molecular Pharmacology. 50: 1223-30. PMID 8913354  0.6
1996 Purohit A, Woo LW, Singh A, Winterborn CJ, Potter BV, Reed MJ. In vivo activity of 4-methylcoumarin-7-O-sulfamate, a nonsteroidal, nonestrogenic steroid sulfatase inhibitor. Cancer Research. 56: 4950-5. PMID 8895749  0.56
1996 Woo LW, Purohit A, Reed MJ, Potter BV. Active site directed inhibition of estrone sulfatase by nonsteroidal coumarin sulfamates. Journal of Medicinal Chemistry. 39: 1349-51. PMID 8691463 DOI: 10.1021/jm950931z  0.56
1996 Woo LW, Lightowler M, Purohit A, Reed MJ, Potter BV. Heteroatom-substituted analogues of the active-site directed inhibitor estra-1,3,5(10)-trien-17-one-3-sulphamate inhibit estrone sulphatase by a different mechanism. The Journal of Steroid Biochemistry and Molecular Biology. 57: 79-88. PMID 8645620 DOI: 10.1016/0960-0760(95)00244-8  0.56
1995 Ward SG, Mills SJ, Liu C, Westwick J, Potter BV. D-myo-inositol 1,4,5-trisphosphate analogues modified at the 3-position inhibit phosphatidylinositol 3-kinase. The Journal of Biological Chemistry. 270: 12075-84. PMID 7744856 DOI: 10.1074/jbc.270.20.12075  0.6
1994 Safrany ST, Mills SJ, Liu C, Lampe D, Noble NJ, Nahorski SR, Potter BV. Design of potent and selective inhibitors of myo-inositol 1,4,5-trisphosphate 5-phosphatase. Biochemistry. 33: 10763-9. PMID 8075077  0.92
1994 Wilcox RA, Safrany ST, Lampe D, Mills SJ, Nahorski SR, Potter BV. Modification at C2 of myo-inositol 1,4,5-trisphosphate produces inositol trisphosphates and tetrakisphosphates with potent biological activities. European Journal of Biochemistry / Febs. 223: 115-24. PMID 8033885 DOI: 10.1111/j.1432-1033.1994.tb18972.x  0.6
1993 Safrany ST, Wilcox RA, Liu C, Dubreuil D, Potter BVL, Nahorski SR. Identification of partial agonists with low intrinsic activity at the inositol-1,4,5-trisphosphate receptor Molecular Pharmacology. 43: 499-503. PMID 8386304  0.6
1993 Wilcox RA, Challiss RA, Baudin G, Vasella A, Potter BV, Nahorski SR. Stereoselectivity of Ins(1,3,4,5)P4 recognition sites: implications for the mechanism of the Ins(1,3,4,5)P4-induced Ca2+ mobilization. The Biochemical Journal. 294: 191-4. PMID 8363572 DOI: 10.1042/bj2940191  0.4
1993 Wilcox RA, Whitham EM, Liu C, Potter BV, Nahorski SR. Myo-inositol 1,3,4,5-tetrakisphosphate can independently mobilise intracellular calcium, via the inositol 1,4,5-trisphosphate receptor: studies with myo-inositol 1,4,5-trisphosphate-3-phosphorothioate and myo-inositol hexakisphosphate. Febs Letters. 336: 267-71. PMID 8262243 DOI: 10.1016/0014-5793(93)80817-e  0.4
1993 Wilcox RA, Challiss RA, Liu C, Potter BV, Nahorski SR. Inositol-1,3,4,5-tetrakisphosphate induces calcium mobilization via the inositol-1,4,5-trisphosphate receptor in SH-SY5Y neuroblastoma cells. Molecular Pharmacology. 44: 810-7. PMID 8232232  0.4
1992 Wilcox RA, Nahorski SR, Sawyer DA, Liu C, Potter BV. The role of the 2- and 3-hydroxyl groups of 1D-myo-inositol 1,4,5-trisphosphate in the mobilisation of calcium from permeabilised human 1321N1 astrocytoma cells. Carbohydrate Research. 234: 237-46. PMID 1334801 DOI: 10.1016/0008-6215(92)85051-z  0.4
1992 Safrany ST, Sawyer DA, Nahorski SR, Potter BV. Synthetic D- and L-enantiomers of 2,2-difluoro-2-deoxy-myo-inositol 1,4,5-trisphosphate interact differently with myo-inositol 1,4,5-trisphosphate binding proteins: identification of a potent small molecule 3-kinase inhibitor. Chirality. 4: 415-22. PMID 1334423 DOI: 10.1002/chir.530040703  0.52
1992 Safrany ST, Wilcox RA, Liu C, Potter BV, Nahorski SR. 3-position modification of myo-inositol 1,4,5-trisphosphate: consequences for intracellular Ca2+ mobilisation and enzyme recognition. European Journal of Pharmacology. 226: 265-72. PMID 1330634 DOI: 10.1016/0922-4106(92)90071-3  0.52
1992 Potter BV, Nahorski SR. Synthesis and biology of inositol polyphosphate analogues. Biochemical Society Transactions. 20: 434-42. PMID 1327920 DOI: 10.1042/bst0200434  0.4
1991 Challiss RA, Willcocks AL, Mulloy B, Potter BV, Nahorski SR. Characterization of inositol 1,4,5-trisphosphate- and inositol 1,3,4,5-tetrakisphosphate-binding sites in rat cerebellum. The Biochemical Journal. 274: 861-7. PMID 2012613  0.6
1991 Challiss RA, Willcocks AL, Potter BV, Nahorski SR. Comparison of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate binding sites in cerebellum. Biochemical Society Transactions. 19: 151S. PMID 1889544  0.6
1991 Challiss RA, Smith SM, Potter BV, Nahorski SR. D-[35S(U)]inositol 1,4,5-trisphosphorothioate, a novel radioligand for the inositol 1,4,5-trisphosphate receptor. Complex binding to rat cerebellar membranes. Febs Letters. 281: 101-4. PMID 1849834 DOI: 10.1016/0014-5793(91)80368-d  0.4
1991 Safrany ST, Wojcikiewicz RJH, Strupish J, Nahorski SR, Dubreuil D, Cleophax J, Gero SD, Potter BVL. Interaction of synthetic D-6-deoxy-myo-inositol 1,4,5-trisphosphate with the Ca2+-releasing D-myo-inositol 1,4,5-trisphosphate receptor, and the metabolic enzymes 5-phosphatase and 3-kinase Febs Letters. 278: 252-256. PMID 1846823 DOI: 10.1016/0014-5793(91)80128-P  0.6
1991 Challiss RA, Safrany ST, Potter BV, Nahorski SR. Intracellular recognition sites for inositol 1,4,5-triphosphate and inositol 1,3,4,5-tetrakisphosphate. Biochemical Society Transactions. 19: 888-93. PMID 1665446 DOI: 10.1042/bst0190888  0.52
1991 Strupish J, Wojcikiewicz RJ, Challiss RA, Safrany ST, Willcocks AL, Potter BV, Nahorski SR. Is decavanadate a specific inositol 1,4,5-trisphosphate receptor antagonist? The Biochemical Journal. 277: 294. PMID 1649602  0.6
1991 Safrany ST, Wojcikiewicz RJH, Strupish J, Mcbain J, Cooke AM, Potter BVL, Nahorski SR. Synthetic phosphorothioate-containing analogues of inositol 1,4,5-trisphosphate mobilize intracellular Ca2+ stores and interact differentially with inositol 1,4,5-trisphosphate 5-phosphatase and 3-kinase Molecular Pharmacology. 39: 754-761. PMID 1646949  0.6
1991 Gawler DJ, Potter BV, Gigg R, Nahorski SR. Interactions between inositol tris- and tetrakis-phosphates. Effects on intracellular Ca2+ mobilization in SH-SY5Y cells. The Biochemical Journal. 276: 163-7. PMID 1645528 DOI: 10.1042/bj2760163  0.4
1990 Wojcikiewicz RJH, Cooke AM, Potter BVL, Nahorski SR. Inhibition of inositol 1,4,5-trisphosphate metabolism in permeabilised SH-SY5Y human neuroblastoma cells by a phosphorothioate-containing analogue of inositol 1,4,5-trisphosphate European Journal of Biochemistry. 192: 459-467. PMID 2209601 DOI: 10.1111/j.1432-1033.1990.tb19248.x  0.6
1990 Gawler DJ, Potter BV, Nahorski SR. Inositol 1,3,4,5-tetrakisphosphate-induced release of intracellular Ca2+ in SH-SY5Y neuroblastoma cells. The Biochemical Journal. 272: 519-24. PMID 2176465 DOI: 10.1042/bj2720519  0.4
1990 Safrany ST, Sawyer D, Wojcikiewicz RJ, Nahorski SR, Potter BV. Ca2(+)-mobilising properties of synthetic fluoro-analogues of myo-inositol 1,4,5-trisphosphate and their interaction with myo-inositol 1,4,5-trisphosphate 3-kinase and 5-phosphatase. Febs Letters. 276: 91-4. PMID 2176165 DOI: 10.1016/0014-5793(90)80515-k  0.52
1990 Chilvers ER, Challiss RA, Willcocks AL, Potter BV, Barnes PJ, Nahorski SR. Characterisation of stereospecific binding sites for inositol 1,4,5-trisphosphate in airway smooth muscle. British Journal of Pharmacology. 99: 297-302. PMID 2158373  0.6
1990 Nunn DL, Potter BV, Taylor CW. Molecular target sizes of inositol 1,4,5-trisphosphate receptors in liver and cerebellum. The Biochemical Journal. 265: 393-8. PMID 2154187 DOI: 10.1042/bj2650393  0.64
1989 Nahorski SR, Potter BV. Molecular recognition of inositol polyphosphates by intracellular receptors and metabolic enzymes. Trends in Pharmacological Sciences. 10: 139-44. PMID 2546303 DOI: 10.1016/0165-6147(89)90165-x  0.4
1989 Cooke AM, Nahorski SR, Potter BVL. myo-Inositol 1,4,5-trisphosphorothioate is a potent competitive inhibitor of human erythrocyte 5-phosphatase Febs Letters. 242: 373-377. PMID 2536622 DOI: 10.1016/0014-5793(89)80504-6  0.6
1988 Strupish J, Cooke AM, Potter BVL, Gigg R, Nahoprski SR. Stereospecific mobilization of intracellular Ca2+ by inositol 1,4,5-trisphosphate. Comparison with inositol 1,4,5-trisphosphorothioate and inositol 1,3,4-trisphosphate Biochemical Journal. 253: 901-905. PMID 3263119  0.6
1988 Willcocks AL, Potter BV, Cooke AM, Nahorski SR. Myo-inositol(1,4,5)trisphosphorothioate binds to specific [3H]inositol(1,4,5)trisphosphate sites in rat cerebellum and is resistant to 5-phosphatase. European Journal of Pharmacology. 155: 181-3. PMID 2854071 DOI: 10.1016/0014-2999(88)90420-7  0.6
1987 Willcocks AL, Cooke AM, Potter BV, Nahorski SR. Stereospecific recognition sites for [3H]inositol(1,4,5)-triphosphate in particulate preparations of rat cerebellum. Biochemical and Biophysical Research Communications. 146: 1071-8. PMID 3039991 DOI: 10.1016/0006-291X(87)90756-X  0.6
1984 Potter BV, Eckstein F. Cleavage of phosphorothioate-substituted DNA by restriction endonucleases. The Journal of Biological Chemistry. 259: 14243-8. PMID 6094546  0.96
1984 Connolly BA, Potter BVL, Eckstein F, Pingoud A, Grotjahn L. Synthesis and characterization of an octanucleotide containing the EcoRI recognition sequence with a phosphorothioate group at the cleavage site Biochemistry. 23: 3443-3453. PMID 6087894  0.6
1983 Potter BV, Eckstein F, Uznański B. A stereospecifically 18O-labelled deoxydinucleoside phosphate block for incorporation into an oligonucleotide. Nucleic Acids Research. 11: 7087-103. PMID 6634410 DOI: 10.1093/nar/11.20.7087  0.96
1983 Potter BVL, Connolly BA, Eckstein F. Synthesis and configurational analysis of a dinucleoside phosphate isotopically chiral at phosphorus. Stereochemical course of Penicillium citrum nuclease P1 reaction Biochemistry. 22: 1369-1377. PMID 6301546  0.6
1983 Potter BV, Romaniuk PJ, Eckstein F. Stereochemical course of DNA hydrolysis by nuclease S1 Journal of Biological Chemistry. 258: 1758-1760. PMID 6296110  0.6
1982 Pollard-Knight D, Potter BV, Cullis PM, Lowe G, Cornish-Bowden A. The stereochemical course of phosphoryl transfer catalysed by glucokinase. The Biochemical Journal. 201: 421-3. PMID 6896275  0.6
1982 Lowe G, Potter BV. The stereochemical course of phosphoryl transfer catalysed by glucose 6-phosphatase. The Biochemical Journal. 201: 665-8. PMID 6284126 DOI: 10.1042/bj2010665  1
1981 Lowe G, Potter BV. The stereochemical course of yeast hexokinase-catalysed phosphoryl transfer by using adenosine 5'[gamma(S)-16O,17O,18O]triphosphate as substrate. The Biochemical Journal. 199: 227-33. PMID 7039616 DOI: 10.1042/bj1990227  1
1981 Lowe G, Potter BV. A stereochemical investigation of phosphoryl transfer catalysed by phosphoglucomutase by the use of alpha-D-glucose 1-[(S)-16O,17O,18O]phosphate. The Biochemical Journal. 199: 693-8. PMID 6462135 DOI: 10.1042/bj1990693  1
1981 Jarvest RL, Lowe G, Potter BV. The stereochemical course of phosphoryl transfer catalysed by Bacillus stearothermophilus and rabbit skeletal-muscle phosphofructokinase with a chiral [16O,17O,18O]phosphate ester. The Biochemical Journal. 199: 427-32. PMID 6462132 DOI: 10.1042/bj1990427  1
1981 Lowe G, Cullis PM, Jarvest RL, Potter BV, Sproat BS. Stereochemistry of phosphoryl transfer. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 293: 75-92. PMID 6115426 DOI: 10.1098/rstb.1981.0062  1
1980 Jones VT, Lowe G, Potter BV. Evidence against a step-wise mechanism for the fumarase-catalysed dehydration of (2S)-malate. European Journal of Biochemistry. 108: 433-7. PMID 7408860 DOI: 10.1111/j.1432-1033.1980.tb04739.x  1
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