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Xiaoyu Zhang - Publications

Affiliations: 
Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
Biochemistry, Chemical biology, Cell biology
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41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2025 Basu AA, Zhang C, Rouhimoghadam M, Vasudevan A, Reitsma JM, Zhang X. Harnessing the FBXW7 Somatic Mutant R465C for Targeted Protein Degradation. Journal of the American Chemical Society. PMID 39913332 DOI: 10.1021/jacs.4c17331  0.321
2025 Campos MA, Riha IA, Zhang C, Mozes C, Scheidt KA, Zhang X. Discovery of DCAF16 Binders for Targeted Protein Degradation. Acs Chemical Biology. PMID 39882752 DOI: 10.1021/acschembio.4c00799  0.336
2024 Riha IA, Campos MA, Jin X, Wang FY, Zhang C, Dunne SF, Cravatt BF, Zhang X. Exploiting the DCAF16-SPIN4 interaction to identify DCAF16 ligands for PROTAC development. Rsc Medicinal Chemistry. PMID 39691404 DOI: 10.1039/d4md00681j  0.519
2024 Basu AA, Zhang C, Rouhimoghadam M, Vasudevan A, Reitsma JM, Zhang X. Harnessing the FBXW7 somatic mutant R465C for targeted protein degradation. Biorxiv : the Preprint Server For Biology. PMID 39677626 DOI: 10.1101/2024.12.03.626601  0.321
2024 Scott KA, Kojima H, Ropek N, Warren CD, Zhang TL, Hogg SJ, Sanford H, Webster C, Zhang X, Rahman J, Melillo B, Cravatt BF, Lyu J, Abdel-Wahab O, Vinogradova EV. Covalent targeting of splicing in T cells. Cell Chemical Biology. PMID 39591969 DOI: 10.1016/j.chembiol.2024.10.010  0.653
2023 Scott KA, Kojima H, Ropek N, Warren CD, Zhang TL, Hogg SJ, Webster C, Zhang X, Rahman J, Melillo B, Cravatt BF, Lyu J, Abdel-Wahab O, Vinogradova EV. Covalent Targeting of Splicing in T Cells. Biorxiv : the Preprint Server For Biology. PMID 38187674 DOI: 10.1101/2023.12.18.572199  0.658
2023 Basu AA, Zhang C, Riha IA, Magassa A, Ko F, Zhang X. A CRISPR activation screen identifies FBXO22 as an E3 ligase supporting targeted protein degradation. Biorxiv : the Preprint Server For Biology. PMID 37745578 DOI: 10.1101/2023.09.15.557708  0.308
2023 Tao Y, Remillard D, Vinogradova EV, Yokoyama M, Banchenko S, Schwefel D, Melillo B, Schreiber SL, Zhang X, Cravatt BF. Correction to "Targeted Protein Degradation by Electrophilic PROTACs that Stereoselectively and Site-Specifically Engage DCAF1". Journal of the American Chemical Society. PMID 37268298 DOI: 10.1021/jacs.3c05058  0.601
2022 Tao Y, Remillard D, Vinogradova EV, Yokoyama M, Banchenko S, Schwefel D, Melillo B, Schreiber SL, Zhang X, Cravatt BF. Targeted Protein Degradation by Electrophilic PROTACs that Stereoselectively and Site-Specifically Engage DCAF1. Journal of the American Chemical Society. PMID 36170674 DOI: 10.1021/jacs.2c08964  0.649
2022 Miller SP, Maio G, Zhang X, Badillo Soto FS, Zhu J, Ramirez SZ, Lin H. A proteomic approach identifies isoform-specific and nucleotide-dependent RAS interactions. Molecular & Cellular Proteomics : McP. 100268. PMID 35839996 DOI: 10.1016/j.mcpro.2022.100268  0.538
2021 Hong JY, Malgapo MIP, Liu Y, Yang M, Zhu C, Zhang X, Tolbert P, Linder ME, Lin H. Correction to "High-Throughput Enzyme Assay for Screening Inhibitors of the ZDHHC3/7/20 Acyltransferases". Acs Chemical Biology. PMID 34514789 DOI: 10.1021/acschembio.1c00674  0.476
2021 Hong JY, Malgapo MIP, Liu Y, Yang M, Zhu C, Zhang X, Tolbert P, Linder ME, Lin H. High-Throughput Enzyme Assay for Screening Inhibitors of the ZDHHC3/7/20 Acyltransferases. Acs Chemical Biology. PMID 34374518 DOI: 10.1021/acschembio.1c00258  0.555
2021 Garnar-Wortzel L, Bishop TR, Kitamura S, Milosevich N, Asiaban JN, Zhang X, Zheng Q, Chen E, Ramos AR, Ackerman CJ, Hampton EN, Chatterjee AK, Young TS, Hull MV, Sharpless KB, et al. Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia. Acs Central Science. 7: 815-830. PMID 34079898 DOI: 10.1021/acscentsci.0c01550  0.749
2021 Zhang X, Luukkonen LM, Eissler CL, Crowley VM, Yamashita Y, Schafroth MA, Kikuchi S, Weinstein DS, Symons KT, Nordin BE, Rodriguez JL, Wucherpfennig TG, Bauer LG, Dix MM, Stamos D, et al. DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras. Journal of the American Chemical Society. PMID 33783207 DOI: 10.1021/jacs.1c00990  0.752
2021 Zhang X, Thielert M, Li H, Cravatt BF. SPIN4 Is a Principal Endogenous Substrate of the E3 Ubiquitin Ligase DCAF16. Biochemistry. PMID 33636084 DOI: 10.1021/acs.biochem.1c00067  0.424
2020 Vinogradova EV, Zhang X, Remillard D, Lazar DC, Suciu RM, Wang Y, Bianco G, Yamashita Y, Crowley VM, Schafroth MA, Yokoyama M, Konrad DB, Lum KM, Simon GM, Kemper EK, et al. An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. PMID 32730809 DOI: 10.1016/J.Cell.2020.07.001  0.724
2020 Kosciuk T, Price IR, Zhang X, Zhu C, Johnson KN, Zhang S, Halaby SL, Komaniecki GP, Yang M, DeHart CJ, Thomas PM, Kelleher NL, Christopher Fromme J, Lin H. NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle. Nature Communications. 11: 1067. PMID 32103017 DOI: 10.1038/S41467-020-14893-X  0.677
2019 Yamashita Y, Vinogradova E, Zhang X, Suciu R, Cravatt B. A chemical proteomic probe for the mitochondrial pyruvate carrier complex. Angewandte Chemie (International Ed. in English). PMID 31863675 DOI: 10.1002/Anie.201914391  0.643
2019 Spiegelman NA, Zhang X, Jing H, Cao J, Kotliar IB, Aramsangtienchai P, Wang M, Tong Z, Rosch KM, Lin H. SIRT2 and Lysine Fatty Acylation Regulate the Activity of RalB and Cell Migration. Acs Chemical Biology. PMID 31433161 DOI: 10.1021/Acschembio.9B00492  0.607
2019 Zhang X, Crowley VM, Wucherpfennig TG, Dix MM, Cravatt BF. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nature Chemical Biology. 15: 737-746. PMID 31209349 DOI: 10.1038/S41589-019-0279-5  0.702
2019 Latifkar A, Ling L, Hingorani A, Johansen E, Clement A, Zhang X, Hartman J, Fischbach C, Lin H, Cerione RA, Antonyak MA. Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity. Developmental Cell. PMID 30982660 DOI: 10.1016/J.Devcel.2019.03.011  0.733
2019 Cao J, Sun L, Aramsangtienchai P, Spiegelman NA, Zhang X, Huang W, Seto E, Lin H. HDAC11 regulates type I interferon signaling through defatty-acylation of SHMT2. Proceedings of the National Academy of Sciences of the United States of America. PMID 30819897 DOI: 10.1073/Pnas.1815365116  0.599
2019 Spiegelman NA, Hong JY, Hu J, Jing H, Wang M, Price IR, Cao J, Yang M, Zhang X, Lin H. A Small Molecule SIRT2 Inhibitor that Promotes K-Ras4a Lysine Fatty-acylation. Chemmedchem. PMID 30734528 DOI: 10.1002/Cmdc.201800715  0.595
2018 Hong JY, Zhang X, Lin H. HPLC-Based Enzyme Assays for Sirtuins. Methods in Molecular Biology (Clifton, N.J.). 1813: 225-234. PMID 30097871 DOI: 10.1007/978-1-4939-8588-3_15  0.574
2018 Spiegelman NA, Price IR, Jing H, Wang M, Yang M, Cao J, Hong JY, Zhang X, Aramsangtienchai P, Sadhukhan S, Lin H. Direct Comparison of SIRT2 Inhibitors: Potency, Specificity, Activity-Dependent Inhibition, and On-target Anticancer Activities. Chemmedchem. PMID 30058233 DOI: 10.1002/Cmdc.201800391  0.582
2018 Zhang X, Cao J, Miller SP, Jing H, Lin H. Comparative Nucleotide-Dependent Interactome Analysis Reveals Shared and Differential Properties of KRas4a and KRas4b. Acs Central Science. 4: 71-80. PMID 29392178 DOI: 10.1021/Acscentsci.7B00440  0.583
2018 Jiang H, Zhang X, Chen X, Aramsangtienchai P, Tong Z, Lin H. Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies. Chemical Reviews. PMID 29292991 DOI: 10.1021/Acs.Chemrev.6B00750  0.601
2018 Latifkar A, Ling L, Zhang X, Fischbach C, Lin H, Cerione R, Antonyak M. Abstract 4506: Loss of SIRT1 alters the secretome of breast cancer cells by impairing lysosomal integrity Cancer Research. 78: 4506-4506. DOI: 10.1158/1538-7445.Am2018-4506  0.734
2017 Jing H, Zhang X, Wisner SA, Chen X, Spiegelman NA, Linder ME, Lin H. SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a. Elife. 6. PMID 29239724 DOI: 10.7554/Elife.32436  0.583
2017 Zhang X, Spiegelman NA, Nelson OD, Jing H, Lin H. SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation. Elife. 6. PMID 28406396 DOI: 10.7554/Elife.25158  0.564
2017 Jing H, Zhang X, Wisner SA, Chen X, Spiegelman NA, Linder ME, Lin H. Author response: SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a Elife. DOI: 10.7554/Elife.32436.026  0.518
2017 Zhang X, Spiegelman NA, Nelson OD, Jing H, Lin H. Author response: SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation Elife. DOI: 10.7554/Elife.25158.019  0.538
2016 Zhang X, Khan S, Jiang H, Antonyak MA, Chen X, Spiegelman NA, Shrimp JH, Cerione RA, Lin H. Identifying the functional contribution of the defatty-acylase activity of SIRT6. Nature Chemical Biology. PMID 27322069 DOI: 10.1038/Nchembio.2106  0.589
2016 Jiang H, Zhang X, Lin H. Lysine fatty acylation promotes lysosomal targeting of TNF-α. Scientific Reports. 6: 24371. PMID 27079798 DOI: 10.1038/Srep24371  0.525
2016 Tong Z, Wang Y, Zhang X, Kim DD, Sadhukhan S, Hao Q, Lin H. SIRT7 is activated by DNA and deacetylates histone H3 in the chromatin context. Acs Chemical Biology. PMID 26907567 DOI: 10.1021/Acschembio.5B01084  0.555
2015 Bai X, Zhang Q, Wu S, Zhang X, Wang M, He F, Wei T, Yang J, Lou Y, Cai Z, Liang T. Characteristics of Tumor Infiltrating Lymphocyte and Circulating Lymphocyte Repertoires in Pancreatic Cancer by the Sequencing of T Cell Receptors. Scientific Reports. 5: 13664. PMID 26329277 DOI: 10.1038/Srep13664  0.306
2014 He B, Hu J, Zhang X, Lin H. Thiomyristoyl peptides as cell-permeable Sirt6 inhibitors. Organic & Biomolecular Chemistry. 12: 7498-502. PMID 25163004 DOI: 10.1039/C4Ob00860J  0.572
2010 Zhang X, Zhao X, Ma Z. PYDDT, a novel phase 2 enzymes inducer, activates Keap1-Nrf2 pathway via depleting the cellular level of glutathione. Toxicology Letters. 199: 93-101. PMID 20800667 DOI: 10.1016/J.Toxlet.2010.08.011  0.338
2010 Shi J, Zhang X, Jiang H. 2-(penta-1,3-diynyl)-5-(3,4-dihydroxybut-1-ynyl)thiophene, a novel NQO1 inducing agent from Echinops grijsii Hance. Molecules (Basel, Switzerland). 15: 5273-81. PMID 20714298 DOI: 10.3390/Molecules15085273  0.311
2010 Zhang X, Ma Z. Characterization of bioactive thiophenes from the dichloromethane extract of Echinops grijisii as Michael addition acceptors. Analytical and Bioanalytical Chemistry. 397: 1975-84. PMID 20437033 DOI: 10.1007/S00216-010-3729-1  0.314
2010 Zhang X, Ma Z, Sun F, Shen L. Abstract 4061: Depleting the cellular level of glutathione and subsequentlyS-glutathionylation of keap1 by electrophilic agents activates keap1-nrf2 pathway Cancer Research. 70: 4061-4061. DOI: 10.1158/1538-7445.Am10-4061  0.318
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