Dennis J. Stuehr - Publications

Cleveland Clinic Foundation, Cleveland, OH, United States 

107 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Dai Y, Sweeny EA, Schlanger S, Ghosh A, Stuehr DJ. GAPDH Delivers Heme to Soluble Guanylyl Cyclase. The Journal of Biological Chemistry. PMID 32358060 DOI: 10.1074/jbc.RA120.013802  1
2020 Garcia V, Park EJ, Siragusa M, Frohlich F, Haque MM, Pascale JV, Heberlein KR, Isakson BE, Stuehr DJ, Sessa WC. Unbiased proteomics identifies plasminogen activator inhibitor-1 as a negative regulator of endothelial nitric oxide synthase. Proceedings of the National Academy of Sciences of the United States of America. PMID 32300005 DOI: 10.1073/pnas.1918761117  1
2019 Porter JJ, Jang HS, Haque MM, Stuehr DJ, Mehl RA. Tyrosine Nitration on Calmodulin Enhances calcium-dependent association and activation of Nitric Oxide Synthase. The Journal of Biological Chemistry. PMID 31914408 DOI: 10.1074/jbc.RA119.010999  1
2019 Koziol-White CJ, Ghosh A, Sandner P, Erzurum SE, Stuehr DJ, Panettieri RA. Soluble Guanylate Cyclase Agonists Induce Bronchodilation in Human Small Airways. American Journal of Respiratory Cell and Molecular Biology. PMID 31340135 DOI: 10.1165/rcmb.2019-0001OC  1
2019 Dai Y, Schlanger S, Haque MM, Misra S, Stuehr DJ. Heat shock protein 90 regulates soluble guanylyl cyclase maturation by a dual mechanism. The Journal of Biological Chemistry. PMID 31311859 DOI: 10.1074/jbc.RA119.009016  1
2019 Wei CC, Fabry E, Hay E, Lloyd L, Kaufman N, Yang YP, Stuehr DJ. Metal Binding and Conformational Studies of the Calcium Binding Domain of NADPH Oxidase 5 Reveal its Similarity and Difference to Calmodulin. Journal of Biomolecular Structure & Dynamics. 1-29. PMID 31203730 DOI: 10.1080/07391102.2019.1633409  1
2019 Ghosh A, Dai Y, Biswas P, Stuehr DJ. Myoglobin maturation is driven by the hsp90 chaperone machinery and by soluble guanylyl cyclase. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201802793RR. PMID 31170354 DOI: 10.1096/fj.201802793RR  1
2019 Tejero J, Hunt AP, Santolini J, Lehnert N, Stuehr DJ. Mechanism and regulation of ferrous heme-nitric oxide (NO) oxidation in NO synthases. The Journal of Biological Chemistry. PMID 30926606 DOI: 10.1074/jbc.RA119.007810  1
2018 Stuehr DJ, Haque MM. Nitric Oxide Synthase Enzymology in the Twenty Years After the Nobel Prize. British Journal of Pharmacology. PMID 30402946 DOI: 10.1111/bph.14533  1
2018 Sweeny EA, Singh AB, Chakravarti R, Martinez-Guzman O, Saini A, Haque MM, Garee G, Dans PD, Hannibal L, Reddi AR, Stuehr DJ. Glyceraldehyde 3-phosphate dehydrogenase is a chaperone that allocates labile heme in cells. The Journal of Biological Chemistry. PMID 30012884 DOI: 10.1074/jbc.RA118.004169  1
2018 Majors AK, Chakravarti R, Ruple LM, Leahy R, Stuehr DJ, Lauer M, Erzurum SC, Janocha A, Aronica MA. Nitric oxide alters hyaluronan deposition by airway smooth muscle cells. Plos One. 13: e0200074. PMID 29966020 DOI: 10.1371/journal.pone.0200074  1
2018 Haque MM, Tejero J, Bayachou M, Kenney CT, Stuehr DJ. A Cross-Domain Charge Interaction Governs the Activity of NO Synthase. The Journal of Biological Chemistry. PMID 29414777 DOI: 10.1074/jbc.RA117.000635  1
2018 Ghosh A, Garee G, Sweeny EA, Nakamura Y, Stuehr DJ. Hsp90 chaperones hemoglobin maturation in erythroid and nonerythroid cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 29358373 DOI: 10.1073/pnas.1717993115  1
2017 Altawallbeh G, Haque MM, Streletzky KA, Stuehr DJ, Bayachou M. Endothelial nitric oxide synthase oxygenase on lipid nanodiscs: A nano-assembly reflecting native-like function of eNOS. Biochemical and Biophysical Research Communications. PMID 28958937 DOI: 10.1016/j.bbrc.2017.09.131  1
2017 Dai Y, Haque MM, Stuehr DJ. Restricting the Conformational Freedom of the Neuronal Nitric Oxide Synthase Flavoprotein Domain Reveals Impact on Electron Transfer and Catalysis. The Journal of Biological Chemistry. PMID 28232486 DOI: 10.1074/jbc.M117.777219  1
2017 Stuehr DJ, Vasquez-Vivar J. Nitric oxide synthases-from genes to function. Nitric Oxide : Biology and Chemistry. 63: 29. PMID 28137371 DOI: 10.1016/j.niox.2017.01.005  0.01
2016 Ramasamy S, Haque MM, Gangoda M, Stuehr DJ. Tetrahydrobiopterin Redox Cycling in Nitric-oxide Synthase: Evidence Supports a Through-Heme Electron Delivery. The Febs Journal. PMID 27760279 DOI: 10.1111/febs.13933  1
2016 Haque MM, Sinha Ray S, Stuehr DJ. Phosphorylation Controls Endothelial Nitric Oxide Synthase by Regulating its Conformational Dynamics. The Journal of Biological Chemistry. PMID 27613870 DOI: 10.1074/jbc.M116.737361  1
2016 Gupta I, Ganguly S, Rozanas CR, Stuehr DJ, Panda K. Ascorbate attenuates pulmonary emphysema by inhibiting tobacco smoke and Rtp801-triggered lung protein modification and proteolysis. Proceedings of the National Academy of Sciences of the United States of America. PMID 27382160 DOI: 10.1073/pnas.1600056113  1
2016 Rwere F, Xia C, Im S, Haque MM, Stuehr DJ, Waskell L, Kim JP. Mutants of Cytochrome P450 Reductase Lacking Either Gly-141 or Gly-143 Destabilize Its FMN Semiquinone. The Journal of Biological Chemistry. PMID 27189945 DOI: 10.1074/jbc.M116.724625  1
2016 Ghosh S, Gupta MK, Xu W, Mavrakis DA, Janocha AJ, Comhair SA, Haque MM, Stuehr DJ, Yu J, Polgar P, Naga Prasad SV, Erzurum SC. Phosphorylation inactivation of endothelial nitric oxide synthesis in pulmonary arterial hypertension. American Journal of Physiology. Lung Cellular and Molecular Physiology. ajplung.00092.2016. PMID 27130529 DOI: 10.1152/ajplung.00092.2016  1
2016 Ghosh A, Koziol-White CJ, Asosingh K, Cheng G, Ruple L, Groneberg D, Friebe A, Comhair SA, Stasch JP, Panettieri RA, Aronica MA, Erzurum SC, Stuehr DJ. Soluble guanylate cyclase as an alternative target for bronchodilator therapy in asthma. Proceedings of the National Academy of Sciences of the United States of America. PMID 27071111 DOI: 10.1073/pnas.1524398113  1
2016 Wang ZQ, Haque MM, Binder K, Sharma M, Wei CC, Stuehr DJ. Engineering nitric oxide synthase chimeras to function as NO dioxygenases. Journal of Inorganic Biochemistry. PMID 27013266 DOI: 10.1016/j.jinorgbio.2016.03.002  1
2016 Ghosh A, Stuehr D. Regulation of sGC via hsp90, cellular heme, sGC agonists, and NO: New pathways and clinical perspectives. Antioxidants & Redox Signaling. PMID 26983679 DOI: 10.1089/ars.2016.6690  1
2016 Jeandroz S, Wipf D, Stuehr DJ, Lamattina L, Melkonian M, Tian Z, Zhu Y, Carpenter EJ, Wong GK, Wendehenne D. Occurrence, structure, and evolution of nitric oxide synthase-like proteins in the plant kingdom. Science Signaling. 9: re2. PMID 26933064 DOI: 10.1126/scisignal.aad4403  1
2015 He Y, Haque MM, Stuehr DJ, Lu HP. Single-molecule spectroscopy reveals how calmodulin activates NO synthase by controlling its conformational fluctuation dynamics. Proceedings of the National Academy of Sciences of the United States of America. PMID 26311846 DOI: 10.1073/pnas.1508829112  1
2015 Sarkar A, Dai Y, Haque MM, Seeger F, Ghosh A, Garcin ED, Montfort WR, Hazen SL, Misra S, Stuehr DJ. Heat Shock Protein 90 Associates with the Per-Arnt-Sim Domain of Heme-free Soluble Guanylate Cyclase: Implications for Enzyme Maturation. The Journal of Biological Chemistry. PMID 26134567 DOI: 10.1074/jbc.M115.645515  1
2015 Jensen D, Reynolds N, Yang YP, Shakya S, Wang ZQ, Stuehr DJ, Wei CC. The exchanged EF-hands in calmodulin and troponin C chimeras impair the Ca²⁺-induced hydrophobicity and alter the interaction with Orai1: a spectroscopic, thermodynamic and kinetic study. Bmc Biochemistry. 16: 6. PMID 25888318 DOI: 10.1186/s12858-015-0036-7  1
2015 Zhang H, Amick J, Chakravarti R, Santarriaga S, Schlanger S, McGlone C, Dare M, Nix JC, Scaglione KM, Stuehr DJ, Misra S, Page RC. A bipartite interaction between Hsp70 and CHIP regulates ubiquitination of chaperoned client proteins. Structure (London, England : 1993). 23: 472-82. PMID 25684577 DOI: 10.1016/j.str.2015.01.003  1
2015 Chakravarti R, Gupta K, Majors A, Ruple L, Aronica M, Stuehr DJ. Novel insights in mammalian catalase heme maturation: EFFect of NO and thioredoxin-1. Free Radical Biology & Medicine. 82: 105-13. PMID 25659933 DOI: 10.1016/j.freeradbiomed.2015.01.030  1
2015 Hannibal L, Page RC, Haque MM, Bolisetty K, Yu Z, Misra S, Stuehr DJ. Dissecting structural and electronic effects in inducible nitric oxide synthase. The Biochemical Journal. 467: 153-65. PMID 25608846 DOI: 10.1042/BJ20141319  1
2014 Haque MM, Bayachou M, Tejero J, Kenney CT, Pearl NM, Im SC, Waskell L, Stuehr DJ. Distinct conformational behaviors of four mammalian dual-flavin reductases (cytochrome P450 reductase, methionine synthase reductase, neuronal nitric oxide synthase, endothelial nitric oxide synthase) determine their unique catalytic profiles Febs Journal. 281: 5325-5340. PMID 25265015 DOI: 10.1111/febs.13073  1
2014 Revsbech IG, Shen X, Chakravarti R, Jensen FB, Thiel B, Evans AL, Kindberg J, Fröbert O, Stuehr DJ, Kevil CG, Fago A. Hydrogen sulfide and nitric oxide metabolites in the blood of free-ranging brown bears and their potential roles in hibernation. Free Radical Biology & Medicine. 73: 349-57. PMID 24909614 DOI: 10.1016/j.freeradbiomed.2014.05.025  1
2014 Ghosh A, Stasch JP, Papapetropoulos A, Stuehr DJ. Nitric oxide and heat shock protein 90 activate soluble guanylate cyclase by driving rapid change in its subunit interactions and heme content. The Journal of Biological Chemistry. 289: 15259-71. PMID 24733395 DOI: 10.1074/jbc.M114.559393  1
2013 Benson MA, Batchelor H, Chuaiphichai S, Bailey J, Zhu H, Stuehr DJ, Bhattacharya S, Channon KM, Crabtree MJ. A pivotal role for tryptophan 447 in enzymatic coupling of human endothelial nitric oxide synthase (eNOS): effects on tetrahydrobiopterin-dependent catalysis and eNOS dimerization. The Journal of Biological Chemistry. 288: 29836-45. PMID 23965989 DOI: 10.1074/jbc.M113.493023  1
2013 Haque MM, Tejero J, Bayachou M, Wang ZQ, Fadlalla M, Stuehr DJ. Thermodynamic characterization of five key kinetic parameters that define neuronal nitric oxide synthase catalysis. The Febs Journal. 280: 4439-53. PMID 23789902 DOI: 10.1111/febs.12404  1
2013 Nagpal L, Haque MM, Saha A, Mukherjee N, Ghosh A, Ranu BC, Stuehr DJ, Panda K. Mechanism of inducible nitric-oxide synthase dimerization inhibition by novel pyrimidine imidazoles. The Journal of Biological Chemistry. 288: 19685-97. PMID 23696643 DOI: 10.1074/jbc.M112.446542  1
2013 Haque MM, Bayachou M, Fadlalla MA, Durra D, Stuehr DJ. Charge-pairing interactions control the conformational setpoint and motions of the FMN domain in neuronal nitric oxide synthase. The Biochemical Journal. 450: 607-17. PMID 23289611 DOI: 10.1042/BJ20121488  1
2013 Sabat J, Egawa T, Lu C, Stuehr DJ, Gerfen GJ, Rousseau DL, Yeh SR. Catalytic intermediates of inducible nitric-oxide synthase stabilized by the W188H mutation. The Journal of Biological Chemistry. 288: 6095-106. PMID 23269673 DOI: 10.1074/jbc.M112.403238  1
2013 McKenna KC, Beatty KM, Scherder RC, Li F, Liu H, Chen AF, Ghosh A, Stuehr DJ. Ascorbate in aqueous humor augments nitric oxide production by macrophages. Journal of Immunology (Baltimore, Md. : 1950). 190: 556-64. PMID 23241881 DOI: 10.4049/jimmunol.1201754  1
2012 Hannibal L, Collins D, Brassard J, Chakravarti R, Vempati R, Dorlet P, Santolini J, Dawson JH, Stuehr DJ. Heme binding properties of glyceraldehyde-3-phosphate dehydrogenase. Biochemistry. 51: 8514-29. PMID 22957700 DOI: 10.1021/bi300863a  1
2012 Ghosh A, Stuehr DJ. Soluble guanylyl cyclase requires heat shock protein 90 for heme insertion during maturation of the NO-active enzyme. Proceedings of the National Academy of Sciences of the United States of America. 109: 12998-3003. PMID 22837396 DOI: 10.1073/pnas.1205854109  1
2012 Jia J, Arif A, Willard B, Smith JD, Stuehr DJ, Hazen SL, Fox PL. Protection of extraribosomal RPL13a by GAPDH and dysregulation by S-nitrosylation. Molecular Cell. 47: 656-63. PMID 22771119 DOI: 10.1016/j.molcel.2012.06.006  1
2012 Haque MM, Fadlalla MA, Aulak KS, Ghosh A, Durra D, Stuehr DJ. Control of electron transfer and catalysis in neuronal nitric-oxide synthase (nNOS) by a hinge connecting its FMN and FAD-NADPH domains. The Journal of Biological Chemistry. 287: 30105-16. PMID 22722929 DOI: 10.1074/jbc.M112.339697  1
2012 Wei CC, Reynolds N, Palka C, Wetherell K, Boyle T, Yang YP, Wang ZQ, Stuehr DJ. Characterization of the 1st and 2nd EF-hands of NADPH oxidase 5 by fluorescence, isothermal titration calorimetry, and circular dichroism. Chemistry Central Journal. 6: 29. PMID 22490336 DOI: 10.1186/1752-153X-6-29  1
2012 Chakravarti R, Stuehr DJ. Thioredoxin-1 regulates cellular heme insertion by controlling S-nitrosation of glyceraldehyde-3-phosphate dehydrogenase. The Journal of Biological Chemistry. 287: 16179-86. PMID 22457359 DOI: 10.1074/jbc.M112.342758  1
2012 Wang ZQ, Tejero J, Wei CC, Haque MM, Santolini J, Fadlalla M, Biswas A, Stuehr DJ. Arg375 tunes tetrahydrobiopterin functions and modulates catalysis by inducible nitric oxide synthase. Journal of Inorganic Biochemistry. 108: 203-15. PMID 22173094 DOI: 10.1016/j.jinorgbio.2011.11.015  1
2011 Hannibal L, Somasundaram R, Tejero J, Wilson A, Stuehr DJ. Influence of heme-thiolate in shaping the catalytic properties of a bacterial nitric-oxide synthase. The Journal of Biological Chemistry. 286: 39224-35. PMID 21921039 DOI: 10.1074/jbc.M111.286351  1
2011 Haque MM, Kenney C, Tejero J, Stuehr DJ. A kinetic model linking protein conformational motions, interflavin electron transfer and electron flux through a dual-flavin enzyme-simulating the reductase activity of the endothelial and neuronal nitric oxide synthase flavoprotein domains. The Febs Journal. 278: 4055-69. PMID 21848659 DOI: 10.1111/j.1742-4658.2011.08310.x  1
2011 Ghosh A, Chawla-Sarkar M, Stuehr DJ. Hsp90 interacts with inducible NO synthase client protein in its heme-free state and then drives heme insertion by an ATP-dependent process. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 2049-60. PMID 21357526 DOI: 10.1096/fj.10-180554  1
2011 Tejero J, Biswas A, Haque MM, Wang ZQ, Hemann C, Varnado CL, Novince Z, Hille R, Goodwin DC, Stuehr DJ. Mesohaem substitution reveals how haem electronic properties can influence the kinetic and catalytic parameters of neuronal NO synthase. The Biochemical Journal. 433: 163-74. PMID 20950274 DOI: 10.1042/BJ20101353  1
2010 Chakravarti R, Aulak KS, Fox PL, Stuehr DJ. GAPDH regulates cellular heme insertion into inducible nitric oxide synthase. Proceedings of the National Academy of Sciences of the United States of America. 107: 18004-9. PMID 20921417 DOI: 10.1073/pnas.1008133107  1
2010 Maréchal A, Mattioli TA, Stuehr DJ, Santolini J. NO synthase isoforms specifically modify peroxynitrite reactivity. The Febs Journal. 277: 3963-73. PMID 20840589 DOI: 10.1111/j.1742-4658.2010.07786.x  1
2010 Wei CC, Motl N, Levek K, Chen LQ, Yang YP, Johnson T, Hamilton L, Stuehr DJ. Conformational States and kinetics of the calcium binding domain of NADPH oxidase 5. The Open Biochemistry Journal. 4: 59-67. PMID 20648216 DOI: 10.2174/1874091X01004010059  1
2010 Tejero J, Hannibal L, Mustovich A, Stuehr DJ. Surface charges and regulation of FMN to heme electron transfer in nitric-oxide synthase. The Journal of Biological Chemistry. 285: 27232-40. PMID 20592038 DOI: 10.1074/jbc.M110.138842  1
2010 Tejero J, Haque MM, Durra D, Stuehr DJ. A bridging interaction allows calmodulin to activate NO synthase through a bi-modal mechanism. The Journal of Biological Chemistry. 285: 25941-9. PMID 20529840 DOI: 10.1074/jbc.M110.126797  1
2010 Waheed SM, Ghosh A, Chakravarti R, Biswas A, Haque MM, Panda K, Stuehr DJ. Nitric oxide blocks cellular heme insertion into a broad range of heme proteins. Free Radical Biology & Medicine. 48: 1548-58. PMID 20211245 DOI: 10.1016/j.freeradbiomed.2010.02.038  1
2010 Wang ZQ, Wei CC, Stuehr DJ. How does a valine residue that modulates heme-NO binding kinetics in inducible NO synthase regulate enzyme catalysis? Journal of Inorganic Biochemistry. 104: 349-56. PMID 20006999 DOI: 10.1016/j.jinorgbio.2009.11.006  1
2010 Giroud C, Moreau M, Mattioli TA, Balland V, Boucher JL, Xu-Li Y, Stuehr DJ, Santolini J. Role of arginine guanidinium moiety in nitric-oxide synthase mechanism of oxygen activation. The Journal of Biological Chemistry. 285: 7233-45. PMID 19951943 DOI: 10.1074/jbc.M109.038240  1
2010 Guan ZW, Haque MM, Wei CC, Garcin ED, Getzoff ED, Stuehr DJ. Lys842 in neuronal nitric-oxide synthase enables the autoinhibitory insert to antagonize calmodulin binding, increase FMN shielding, and suppress interflavin electron transfer. The Journal of Biological Chemistry. 285: 3064-75. PMID 19948738 DOI: 10.1074/jbc.M109.000810  1
2009 Tejero J, Santolini J, Stuehr DJ. Fast ferrous heme-NO oxidation in nitric oxide synthases. The Febs Journal. 276: 4505-14. PMID 19691141  1
2009 Sabat J, Stuehr DJ, Yeh SR, Rousseau DL. Characterization of the proximal ligand in the P420 form of inducible nitric oxide synthase. Journal of the American Chemical Society. 131: 12186-92. PMID 19658411 DOI: 10.1021/ja901016a  1
2009 Stuehr DJ, Tejero J, Haque MM. Structural and mechanistic aspects of flavoproteins: electron transfer through the nitric oxide synthase flavoprotein domain. The Febs Journal. 276: 3959-74. PMID 19583767 DOI: 10.1111/j.1742-4658.2009.07120.x  1
2009 Haque MM, Fadlalla M, Wang ZQ, Ray SS, Panda K, Stuehr DJ. Neutralizing a surface charge on the FMN subdomain increases the activity of neuronal nitric-oxide synthase by enhancing the oxygen reactivity of the enzyme heme-nitric oxide complex. The Journal of Biological Chemistry. 284: 19237-47. PMID 19473991 DOI: 10.1074/jbc.M109.013144  1
2009 Koeck T, Corbett JA, Crabb JW, Stuehr DJ, Aulak KS. Glucose-modulated tyrosine nitration in beta cells: targets and consequences. Archives of Biochemistry and Biophysics. 484: 221-31. PMID 19402213 DOI: 10.1016/  1
2009 Ilagan RP, Tejero J, Aulak KS, Ray SS, Hemann C, Wang ZQ, Gangoda M, Zweier JL, Stuehr DJ. Regulation of FMN subdomain interactions and function in neuronal nitric oxide synthase. Biochemistry. 48: 3864-76. PMID 19290671 DOI: 10.1021/bi8021087  1
2009 Fan B, Stuehr DJ, Rousseau DL. Role of substrate functional groups in binding to nitric oxide synthase. Biochemical and Biophysical Research Communications. 382: 21-5. PMID 19248772 DOI: 10.1016/j.bbrc.2009.02.084  1
2009 Koeck T, Willard B, Crabb JW, Kinter M, Stuehr DJ, Aulak KS. Glucose-mediated tyrosine nitration in adipocytes: targets and consequences. Free Radical Biology & Medicine. 46: 884-92. PMID 19135148 DOI: 10.1016/j.freeradbiomed.2008.12.010  1
2008 Garcin ED, Arvai AS, Rosenfeld RJ, Kroeger MD, Crane BR, Andersson G, Andrews G, Hamley PJ, Mallinder PR, Nicholls DJ, St-Gallay SA, Tinker AC, Gensmantel NP, Mete A, Cheshire DR, ... ... Stuehr DJ, et al. Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Nature Chemical Biology. 4: 700-7. PMID 18849972 DOI: 10.1038/nchembio.115  1
2008 Tejero J, Biswas A, Wang ZQ, Page RC, Haque MM, Hemann C, Zweier JL, Misra S, Stuehr DJ. Stabilization and characterization of a heme-oxy reaction intermediate in inducible nitric-oxide synthase. The Journal of Biological Chemistry. 283: 33498-507. PMID 18815130 DOI: 10.1074/jbc.M806122200  1
2008 Donzelli S, Espey MG, Flores-Santana W, Switzer CH, Yeh GC, Huang J, Stuehr DJ, King SB, Miranda KM, Wink DA. Generation of nitroxyl by heme protein-mediated peroxidation of hydroxylamine but not N-hydroxy-L-arginine. Free Radical Biology & Medicine. 45: 578-84. PMID 18503778 DOI: 10.1016/j.freeradbiomed.2008.04.036  1
2008 Ilagan RP, Tiso M, Konas DW, Hemann C, Durra D, Hille R, Stuehr DJ. Differences in a conformational equilibrium distinguish catalysis by the endothelial and neuronal nitric-oxide synthase flavoproteins. The Journal of Biological Chemistry. 283: 19603-15. PMID 18487202 DOI: 10.1074/jbc.M802914200  1
2008 Gusarov I, Starodubtseva M, Wang ZQ, McQuade L, Lippard SJ, Stuehr DJ, Nudler E. Bacterial nitric-oxide synthases operate without a dedicated redox partner. The Journal of Biological Chemistry. 283: 13140-7. PMID 18316370 DOI: 10.1074/jbc.M710178200  1
2008 Wei CC, Wang ZQ, Tejero J, Yang YP, Hemann C, Hille R, Stuehr DJ. Catalytic reduction of a tetrahydrobiopterin radical within nitric-oxide synthase. The Journal of Biological Chemistry. 283: 11734-42. PMID 18283102 DOI: 10.1074/jbc.M709250200  1
2008 Tiso M, Strub A, Hesslinger C, Kenney CT, Boer R, Stuehr DJ. BYK191023 (2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3h-imidazo[4,5-b]pyridine) is an NADPH- and time-dependent irreversible inhibitor of inducible nitric-oxide synthase. Molecular Pharmacology. 73: 1244-53. PMID 18178668 DOI: 10.1124/mol.107.041319  1
2007 Tiso M, Tejero J, Panda K, Aulak KS, Stuehr DJ. Versatile regulation of neuronal nitric oxide synthase by specific regions of its C-terminal tail. Biochemistry. 46: 14418-28. PMID 18020458 DOI: 10.1021/bi701646k  1
2007 Beaumont E, Lambry JC, Wang ZQ, Stuehr DJ, Martin JL, Slama-Schwok A. Distal Val346Ile mutation in inducible NO synthase promotes substrate-dependent NO confinement. Biochemistry. 46: 13533-40. PMID 17973404 DOI: 10.1021/bi701567h  1
2007 Ray SS, Sengupta R, Tiso M, Haque MM, Sahoo R, Konas DW, Aulak K, Regulski M, Tully T, Stuehr DJ, Ghosh S. Reductase domain of Drosophila melanogaster nitric-oxide synthase: redox transformations, regulation, and similarity to mammalian homologues. Biochemistry. 46: 11865-73. PMID 17900149 DOI: 10.1021/bi700805x  1
2007 Ray SS, Tejero J, Wang ZQ, Dutta T, Bhattacharjee A, Regulski M, Tully T, Ghosh S, Stuehr DJ. Oxygenase domain of Drosophila melanogaster nitric oxide synthase: unique kinetic parameters enable a more efficient NO release. Biochemistry. 46: 11857-64. PMID 17900148 DOI: 10.1021/bi700803p  1
2007 Haque MM, Panda K, Tejero J, Aulak KS, Fadlalla MA, Mustovich AT, Stuehr DJ. A connecting hinge represses the activity of endothelial nitric oxide synthase. Proceedings of the National Academy of Sciences of the United States of America. 104: 9254-9. PMID 17517617 DOI: 10.1073/pnas.0700332104  1
2007 Li D, Kabir M, Stuehr DJ, Rousseau DL, Yeh SR. Substrate- and isoform-specific dioxygen complexes of nitric oxide synthase. Journal of the American Chemical Society. 129: 6943-51. PMID 17488012 DOI: 10.1021/ja070683j  1
2007 Maréchal A, Mattioli TA, Stuehr DJ, Santolini J. Activation of peroxynitrite by inducible nitric-oxide synthase: a direct source of nitrative stress. The Journal of Biological Chemistry. 282: 14101-12. PMID 17369257 DOI: 10.1074/jbc.M609237200  1
2007 Xu W, Koeck T, Lara AR, Neumann D, DiFilippo FP, Koo M, Janocha AJ, Masri FA, Arroliga AC, Jennings C, Dweik RA, Tuder RM, Stuehr DJ, Erzurum SC. Alterations of cellular bioenergetics in pulmonary artery endothelial cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 1342-7. PMID 17227868 DOI: 10.1073/pnas.0605080104  1
2007 Jagnandan D, Church JE, Banfi B, Stuehr DJ, Marrero MB, Fulton DJ. Novel mechanism of activation of NADPH oxidase 5. calcium sensitization via phosphorylation. The Journal of Biological Chemistry. 282: 6494-507. PMID 17164239 DOI: 10.1074/jbc.M608966200  0.04
2007 Wang ZQ, Lawson RJ, Buddha MR, Wei CC, Crane BR, Munro AW, Stuehr DJ. Bacterial flavodoxins support nitric oxide production by Bacillus subtilis nitric-oxide synthase. The Journal of Biological Chemistry. 282: 2196-202. PMID 17127770 DOI: 10.1074/jbc.M608206200  1
2006 Konas DW, Takaya N, Sharma M, Stuehr DJ. Role of Asp1393 in catalysis, flavin reduction, NADP(H) binding, FAD thermodynamics, and regulation of the nNOS flavoprotein. Biochemistry. 45: 12596-609. PMID 17029414 DOI: 10.1021/bi061011t  1
2006 Panda K, Haque MM, Garcin-Hosfield ED, Durra D, Getzoff ED, Stuehr DJ. Surface charge interactions of the FMN module govern catalysis by nitric-oxide synthase. The Journal of Biological Chemistry. 281: 36819-27. PMID 17001078 DOI: 10.1074/jbc.M606129200  1
2006 Moreau M, Boucher JL, Mattioli TA, Stuehr DJ, Mansuy D, Santolini J. Differential effects of alkyl- and arylguanidines on the stability and reactivity of inducible NOS heme-dioxygen complexes Biochemistry. 45: 3988-3999. PMID 16548526 DOI: 10.1021/bi051488p  1
2006 Santolini J, Roman M, Stuehr DJ, Mattioli TA. Resonance Raman study of Bacillus subtilis NO synthase-like protein: similarities and differences with mammalian NO synthases. Biochemistry. 45: 1480-9. PMID 16445290 DOI: 10.1021/bi051710q  1
2006 Li D, Hayden EY, Panda K, Stuehr DJ, Deng H, Rousseau DL, Yeh SR. Regulation of the monomer-dimer equilibrium in inducible nitric-oxide synthase by nitric oxide. The Journal of Biological Chemistry. 281: 8197-204. PMID 16421101 DOI: 10.1074/jbc.M507328200  1
2006 Lefèvre-Groboillot D, Boucher JL, Mansuy D, Stuehr DJ. Reactivity of the heme-dioxygen complex of the inducible nitric oxide synthase in the presence of alternative substrates Febs Journal. 273: 180-191. PMID 16367758 DOI: 10.1111/j.1742-4658.2005.05056.x  1
2005 Belliston-Bittner W, Dunn AR, Nguyen YH, Stuehr DJ, Winkler JR, Gray HB. Picosecond photoreduction of inducible nitric oxide synthase by rhenium(I)-diimine wires. Journal of the American Chemical Society. 127: 15907-15. PMID 16277534 DOI: 10.1021/ja0543088  1
2005 Stuehr DJ, Wei CC, Wang Z, Hille R. Exploring the redox reactions between heme and tetrahydrobiopterin in the nitric oxide synthases. Dalton Transactions (Cambridge, England : 2003). 3427-35. PMID 16234921 DOI: 10.1039/b506355h  1
2005 Tiso M, Konas DW, Panda K, Garcin ED, Sharma M, Getzoff ED, Stuehr DJ. C-terminal tail residue Arg1400 enables NADPH to regulate electron transfer in neuronal nitric-oxide synthase. The Journal of Biological Chemistry. 280: 39208-19. PMID 16150731 DOI: 10.1074/jbc.M507775200  1
2005 Panda K, Chawla-Sarkar M, Santos C, Koeck T, Erzurum SC, Parkinson JF, Stuehr DJ. Visualizing inducible nitric-oxide synthase in living cells with a heme-binding fluorescent inhibitor. Proceedings of the National Academy of Sciences of the United States of America. 102: 10117-22. PMID 16006534 DOI: 10.1073/pnas.0408972102  1
2005 Lefèvre-Groboillot D, Boucher JL, Stuehr DJ, Mansuy D. Relationship between the structure of guanidines and N-hydroxyguanidines, their binding to inducible nitric oxide synthase (iNOS) and their iNOS-catalysed oxidation to NO Febs Journal. 272: 3172-3183. PMID 15955074 DOI: 10.1111/j.1742-4658.2005.04736.x  1
2005 Masri FA, Comhair SA, Koeck T, Xu W, Janocha A, Ghosh S, Dweik RA, Golish J, Kinter M, Stuehr DJ, Erzurum SC, Aulak KS. Abnormalities in nitric oxide and its derivatives in lung cancer. American Journal of Respiratory and Critical Care Medicine. 172: 597-605. PMID 15947282 DOI: 10.1164/rccm.200411-1523OC  1
2005 Dunn AR, Belliston-Bittner W, Winkler JR, Getzoff ED, Stuehr DJ, Gray HB. Luminescent ruthenium(II)- and rhenium(I)-diimine wires bind nitric oxide synthase. Journal of the American Chemical Society. 127: 5169-73. PMID 15810851 DOI: 10.1021/ja046971m  1
2005 Jeng BH, Shadrach KG, Meisler DM, Hollyfield JG, Connor JT, Koeck T, Aulak KS, Stuehr DJ. Immunohistochemical detection and Western blot analysis of nitrated protein in stored human corneal epithelium. Experimental Eye Research. 80: 509-14. PMID 15781278 DOI: 10.1016/j.exer.2004.10.015  1
2005 Wang ZQ, Wei CC, Santolini J, Panda K, Wang Q, Stuehr DJ. A tryptophan that modulates tetrahydrobiopterin-dependent electron transfer in nitric oxide synthase regulates enzyme catalysis by additional mechanisms. Biochemistry. 44: 4676-90. PMID 15779894 DOI: 10.1021/bi047508p  1
2005 Wei CC, Wang ZQ, Durra D, Hemann C, Hille R, Garcin ED, Getzoff ED, Stuehr DJ. The three nitric-oxide synthases differ in their kinetics of tetrahydrobiopterin radical formation, heme-dioxy reduction, and arginine hydroxylation. The Journal of Biological Chemistry. 280: 8929-35. PMID 15632185 DOI: 10.1074/jbc.M409737200  1
2004 Stuehr DJ, Wei CC, Santolini J, Wang Z, Aoyagi M, Getzoff ED. Radical reactions of nitric oxide synthases. Biochemical Society Symposium. 39-49. PMID 15777011  1
2004 Stuehr DJ. Enzymes of the L-arginine to nitric oxide pathway. The Journal of Nutrition. 134: 2748S-2751S; discuss. PMID 15465779 DOI: 10.1093/jn/134.10.2748S  0.01
2004 Garcin ED, Bruns CM, Lloyd SJ, Hosfield DJ, Tiso M, Gachhui R, Stuehr DJ, Tainer JA, Getzoff ED. Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase. The Journal of Biological Chemistry. 279: 37918-27. PMID 15208315 DOI: 10.1074/jbc.M406204200  1
2004 Aulak KS, Koeck T, Crabb JW, Stuehr DJ. Proteomic method for identification of tyrosine-nitrated proteins. Methods in Molecular Biology (Clifton, N.J.). 279: 151-65. PMID 15199243 DOI: 10.1385/1-59259-807-2:151  1
2004 Konas DW, Zhu K, Sharma M, Aulak KS, Brudvig GW, Stuehr DJ. The FAD-shielding residue Phe1395 regulates neuronal nitric-oxide synthase catalysis by controlling NADP+ affinity and a conformational equilibrium within the flavoprotein domain. The Journal of Biological Chemistry. 279: 35412-25. PMID 15180983 DOI: 10.1074/jbc.M400872200  1
2004 Stuehr DJ, Santolini J, Wang ZQ, Wei CC, Adak S. Update on mechanism and catalytic regulation in the NO synthases. The Journal of Biological Chemistry. 279: 36167-70. PMID 15133020 DOI: 10.1074/jbc.R400017200  1
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