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Dennis J. Stuehr - Publications

Affiliations: 
Cleveland Clinic Foundation, Cleveland, OH, United States 
Area:
Biochemistry
Website:
https://www.lerner.ccf.org/immuno/stuehr/
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Year Citation  Score
2023 Stuehr DJ, Biswas P, Dai Y, Ghosh A, Islam S, Jayaram DT. A natural heme deficiency exists in biology that allows nitric oxide to control heme protein functions by regulating cellular heme distribution. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. e2300055. PMID 37276366 DOI: 10.1002/bies.202300055  0.344
2023 Biswas P, Stuehr DJ. Indoleamine Dioxygenase and Tryptophan Dioxygenase Activities are Regulated through Control of Cell Heme Allocation by Nitric Oxide. The Journal of Biological Chemistry. 104753. PMID 37116709 DOI: 10.1016/j.jbc.2023.104753  0.32
2023 Richter SM, Massman LC, Stuehr DJ, Sweeny EA. Functional interactions between NADPH oxidase 5 and actin. Frontiers in Cell and Developmental Biology. 11: 1116833. PMID 36776559 DOI: 10.3389/fcell.2023.1116833  0.807
2022 Dai Y, Fleischhacker AS, Liu L, Fayad S, Gunawan AL, Stuehr DJ, Ragsdale SW. Heme delivery to heme oxygenase-2 involves glyceraldehyde-3-phosphate dehydrogenase. Biological Chemistry. PMID 36302634 DOI: 10.1515/hsz-2022-0230  0.305
2022 Stuehr DJ, Dai Y, Biswas P, Sweeny EA, Ghosh A. New roles for GAPDH, Hsp90, and NO in regulating heme allocation and hemeprotein function in mammals. Biological Chemistry. PMID 36152339 DOI: 10.1515/hsz-2022-0197  0.791
2022 Biswas P, Dai Y, Stuehr DJ. Indoleamine dioxygenase and tryptophan dioxygenase activities are regulated through GAPDH- and Hsp90-dependent control of their heme levels. Free Radical Biology & Medicine. 180: 179-190. PMID 35051612 DOI: 10.1016/j.freeradbiomed.2022.01.008  0.431
2022 Dai Y, Faul EM, Ghosh A, Stuehr DJ. NO rapidly mobilizes cellular heme to trigger assembly of its own receptor. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35046034 DOI: 10.1073/pnas.2115774119  0.396
2022 Tupta B, Stuehr E, Sumi MP, Sweeny EA, Smith B, Stuehr DJ, Ghosh A. GAPDH is involved in the heme-maturation of myoglobin and hemoglobin. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 36: e22099. PMID 34972240 DOI: 10.1096/fj.202101237RR  0.792
2021 He Y, Haque MM, Stuehr DJ, Lu HP. Conformational States and Fluctuations in Endothelial Nitric Oxide Synthase under Calmodulin Regulation. Biophysical Journal. PMID 34748763 DOI: 10.1016/j.bpj.2021.11.001  0.395
2021 Sweeny EA, Hunt AP, Batka AE, Schlanger S, Lehnert N, Stuehr DJ. Nitric oxide and heme-NO stimulate superoxide production by NADPH oxidase 5. Free Radical Biology & Medicine. 172: 252-263. PMID 34139309 DOI: 10.1016/j.freeradbiomed.2021.06.008  0.821
2021 Dai Y, Stuehr DJ. Inactivation of sGC in living cells proceeds without heme loss and involves heterodimer dissociation as a common step. British Journal of Pharmacology. PMID 33975383 DOI: 10.1111/bph.15527  0.42
2021 Aulak KS, Ai Abdi S, Li L, Crabb JS, Ghosh A, Willard BB, Stuehr DJ, Crabb JW, Dweik RA, Tonelli AR. Disease Specific Platelet Signaling Defects in Idiopathic Pulmonary Arterial Hypertension. American Journal of Physiology. Lung Cellular and Molecular Physiology. PMID 33596129 DOI: 10.1152/ajplung.00500.2020  0.352
2021 Stuehr DJ, Misra S, Dai Y, Ghosh A. Maturation, Inactivation, and Recovery Mechanisms of Soluble Guanylyl Cyclase. The Journal of Biological Chemistry. 100336. PMID 33508317 DOI: 10.1016/j.jbc.2021.100336  0.381
2020 Ghosh A, Koziol-White CJ, Jester WF, Erzurum SC, Asosingh K, Panettieri RA, Stuehr DJ. An inherent dysfunction in soluble guanylyl cyclase is present in the airway of severe asthmatics and is associated with aberrant redox enzyme expression and compromised NO-cGMP signaling. Redox Biology. 39: 101832. PMID 33360351 DOI: 10.1016/j.redox.2020.101832  0.32
2020 Aulak KS, Barnes JW, Tian L, Mellor NE, Haque MM, Willard B, Li L, Comhair SC, Stuehr DJ, Dweik RA. Specific O-GlcNAc modification at Ser-615 modulates eNOS function. Redox Biology. 36: 101625. PMID 32863226 DOI: 10.1016/J.Redox.2020.101625  0.461
2020 Sweeny EA, Schlanger S, Stuehr DJ. Dynamic regulation of NADPH oxidase 5 by intracellular heme levels and cellular chaperones. Redox Biology. 36: 101656. PMID 32738790 DOI: 10.1016/J.Redox.2020.101656  0.793
2020 Dai Y, Sweeny EA, Schlanger S, Ghosh A, Stuehr DJ. GAPDH Delivers Heme to Soluble Guanylyl Cyclase. The Journal of Biological Chemistry. PMID 32358060 DOI: 10.1074/Jbc.Ra120.013802  0.814
2020 Garcia V, Park EJ, Siragusa M, Frohlich F, Haque MM, Pascale JV, Heberlein KR, Isakson BE, Stuehr DJ, Sessa WC. Unbiased proteomics identifies plasminogen activator inhibitor-1 as a negative regulator of endothelial nitric oxide synthase. Proceedings of the National Academy of Sciences of the United States of America. PMID 32300005 DOI: 10.1073/Pnas.1918761117  0.514
2019 Porter JJ, Jang HS, Haque MM, Stuehr DJ, Mehl RA. Tyrosine Nitration on Calmodulin Enhances calcium-dependent association and activation of Nitric Oxide Synthase. The Journal of Biological Chemistry. PMID 31914408 DOI: 10.1074/Jbc.Ra119.010999  0.521
2019 Koziol-White CJ, Ghosh A, Sandner P, Erzurum SE, Stuehr DJ, Panettieri RA. Soluble Guanylate Cyclase Agonists Induce Bronchodilation in Human Small Airways. American Journal of Respiratory Cell and Molecular Biology. PMID 31340135 DOI: 10.1165/Rcmb.2019-0001Oc  0.363
2019 Dai Y, Schlanger S, Haque MM, Misra S, Stuehr DJ. Heat shock protein 90 regulates soluble guanylyl cyclase maturation by a dual mechanism. The Journal of Biological Chemistry. PMID 31311859 DOI: 10.1074/Jbc.Ra119.009016  0.507
2019 Wei CC, Fabry E, Hay E, Lloyd L, Kaufman N, Yang YP, Stuehr DJ. Metal Binding and Conformational Studies of the Calcium Binding Domain of NADPH Oxidase 5 Reveal its Similarity and Difference to Calmodulin. Journal of Biomolecular Structure & Dynamics. 1-29. PMID 31203730 DOI: 10.1080/07391102.2019.1633409  0.409
2019 Ghosh A, Dai Y, Biswas P, Stuehr DJ. Myoglobin maturation is driven by the hsp90 chaperone machinery and by soluble guanylyl cyclase. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201802793RR. PMID 31170354 DOI: 10.1096/Fj.201802793Rr  0.449
2019 Tejero J, Hunt AP, Santolini J, Lehnert N, Stuehr DJ. Mechanism and regulation of ferrous heme-nitric oxide (NO) oxidation in NO synthases. The Journal of Biological Chemistry. PMID 30926606 DOI: 10.1074/Jbc.Ra119.007810  0.548
2018 Stuehr DJ, Haque MM. Nitric Oxide Synthase Enzymology in the Twenty Years After the Nobel Prize. British Journal of Pharmacology. PMID 30402946 DOI: 10.1111/Bph.14533  0.516
2018 Sweeny EA, Singh AB, Chakravarti R, Martinez-Guzman O, Saini A, Haque MM, Garee G, Dans PD, Hannibal L, Reddi AR, Stuehr DJ. Glyceraldehyde 3-phosphate dehydrogenase is a chaperone that allocates labile heme in cells. The Journal of Biological Chemistry. PMID 30012884 DOI: 10.1074/Jbc.Ra118.004169  0.803
2018 Majors AK, Chakravarti R, Ruple LM, Leahy R, Stuehr DJ, Lauer M, Erzurum SC, Janocha A, Aronica MA. Nitric oxide alters hyaluronan deposition by airway smooth muscle cells. Plos One. 13: e0200074. PMID 29966020 DOI: 10.1371/Journal.Pone.0200074  0.432
2018 Haque MM, Tejero J, Bayachou M, Kenney CT, Stuehr DJ. A Cross-Domain Charge Interaction Governs the Activity of NO Synthase. The Journal of Biological Chemistry. PMID 29414777 DOI: 10.1074/Jbc.Ra117.000635  0.398
2018 Ghosh A, Garee G, Sweeny EA, Nakamura Y, Stuehr DJ. Hsp90 chaperones hemoglobin maturation in erythroid and nonerythroid cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 29358373 DOI: 10.1073/Pnas.1717993115  0.778
2017 Todd Milne G, Sandner P, Lincoln KA, Harrison PC, Chen H, Wang H, Clifford H, Qian HS, Wong D, Sarko C, Fryer R, Richman J, Reinhart GA, Boustany CM, Pullen SS, ... ... Stuehr DJ, et al. Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017. Bmc Pharmacology & Toxicology. 18: 64. PMID 29035170 DOI: 10.1186/s40360-017-0170-5  0.403
2017 Altawallbeh G, Haque MM, Streletzky KA, Stuehr DJ, Bayachou M. Endothelial nitric oxide synthase oxygenase on lipid nanodiscs: A nano-assembly reflecting native-like function of eNOS. Biochemical and Biophysical Research Communications. PMID 28958937 DOI: 10.1016/J.Bbrc.2017.09.131  0.478
2017 Dai Y, Haque MM, Stuehr DJ. Restricting the Conformational Freedom of the Neuronal Nitric Oxide Synthase Flavoprotein Domain Reveals Impact on Electron Transfer and Catalysis. The Journal of Biological Chemistry. PMID 28232486 DOI: 10.1074/Jbc.M117.777219  0.475
2017 Stuehr DJ, Vasquez-Vivar J. Nitric oxide synthases-from genes to function. Nitric Oxide : Biology and Chemistry. 63: 29. PMID 28137371 DOI: 10.1016/J.Niox.2017.01.005  0.474
2017 Ganguly S, Gupta I, Stuehr DJ, Panda K. Oxidant(s) in tobacco smoke is the key etiopathogenic factor for cigarette-smoke induced pulmonary emphysema and vascular remodeling: prevention by vitamin C Free Radical Biology and Medicine. 112: 29. DOI: 10.1016/J.Freeradbiomed.2017.10.033  0.396
2016 Ramasamy S, Haque MM, Gangoda M, Stuehr DJ. Tetrahydrobiopterin Redox Cycling in Nitric-oxide Synthase: Evidence Supports a Through-Heme Electron Delivery. The Febs Journal. PMID 27760279 DOI: 10.1111/Febs.13933  0.483
2016 Haque MM, Sinha Ray S, Stuehr DJ. Phosphorylation Controls Endothelial Nitric Oxide Synthase by Regulating its Conformational Dynamics. The Journal of Biological Chemistry. PMID 27613870 DOI: 10.1074/Jbc.M116.737361  0.503
2016 Gupta I, Ganguly S, Rozanas CR, Stuehr DJ, Panda K. Ascorbate attenuates pulmonary emphysema by inhibiting tobacco smoke and Rtp801-triggered lung protein modification and proteolysis. Proceedings of the National Academy of Sciences of the United States of America. PMID 27382160 DOI: 10.1073/Pnas.1600056113  0.405
2016 Rwere F, Xia C, Im S, Haque MM, Stuehr DJ, Waskell L, Kim JP. Mutants of Cytochrome P450 Reductase Lacking Either Gly-141 or Gly-143 Destabilize Its FMN Semiquinone. The Journal of Biological Chemistry. PMID 27189945 DOI: 10.1074/Jbc.M116.724625  0.481
2016 Ghosh S, Gupta MK, Xu W, Mavrakis DA, Janocha AJ, Comhair SA, Haque MM, Stuehr DJ, Yu J, Polgar P, Naga Prasad SV, Erzurum SC. Phosphorylation inactivation of endothelial nitric oxide synthesis in pulmonary arterial hypertension. American Journal of Physiology. Lung Cellular and Molecular Physiology. ajplung.00092.2016. PMID 27130529 DOI: 10.1152/Ajplung.00092.2016  0.417
2016 Ghosh A, Koziol-White CJ, Asosingh K, Cheng G, Ruple L, Groneberg D, Friebe A, Comhair SA, Stasch JP, Panettieri RA, Aronica MA, Erzurum SC, Stuehr DJ. Soluble guanylate cyclase as an alternative target for bronchodilator therapy in asthma. Proceedings of the National Academy of Sciences of the United States of America. PMID 27071111 DOI: 10.1073/Pnas.1524398113  0.37
2016 Wang ZQ, Haque MM, Binder K, Sharma M, Wei CC, Stuehr DJ. Engineering nitric oxide synthase chimeras to function as NO dioxygenases. Journal of Inorganic Biochemistry. PMID 27013266 DOI: 10.1016/J.Jinorgbio.2016.03.002  0.544
2016 Ghosh A, Stuehr D. Regulation of sGC via hsp90, cellular heme, sGC agonists, and NO: New pathways and clinical perspectives. Antioxidants & Redox Signaling. PMID 26983679 DOI: 10.1089/Ars.2016.6690  0.476
2016 Jeandroz S, Wipf D, Stuehr DJ, Lamattina L, Melkonian M, Tian Z, Zhu Y, Carpenter EJ, Wong GK, Wendehenne D. Occurrence, structure, and evolution of nitric oxide synthase-like proteins in the plant kingdom. Science Signaling. 9: re2. PMID 26933064 DOI: 10.1126/Scisignal.Aad4403  0.437
2016 Gupta I, Ganguly S, Rozanas CR, Stuehr DJ, Panda K. Cigarette Smoke Induced Emphysema and Pulmonary Hypertension Are Triggered by Tobacco Smoke Oxidants: Attenuation by Vitamin C Free Radical Biology and Medicine. 100: S108. DOI: 10.1016/J.Freeradbiomed.2016.10.276  0.411
2015 He Y, Haque MM, Stuehr DJ, Lu HP. Single-molecule spectroscopy reveals how calmodulin activates NO synthase by controlling its conformational fluctuation dynamics. Proceedings of the National Academy of Sciences of the United States of America. PMID 26311846 DOI: 10.1073/Pnas.1508829112  0.456
2015 Sarkar A, Dai Y, Haque MM, Seeger F, Ghosh A, Garcin ED, Montfort WR, Hazen SL, Misra S, Stuehr DJ. Heat Shock Protein 90 Associates with the Per-Arnt-Sim Domain of Heme-free Soluble Guanylate Cyclase: Implications for Enzyme Maturation. The Journal of Biological Chemistry. PMID 26134567 DOI: 10.1074/Jbc.M115.645515  0.456
2015 Chakravarti R, Gupta K, Swain M, Willard B, Scholtz J, Svensson LG, Roselli EE, Pettersson G, Johnston DR, Soltesz EG, Yamashita M, Stuehr D, Daly TM, Hoffman GS. 14-3-3 in Thoracic Aortic Aneurysms: Identification of a Novel Autoantigen in Large Vessel Vasculitis. Arthritis & Rheumatology (Hoboken, N.J.). 67: 1913-21. PMID 25917817 DOI: 10.1002/Art.39130  0.324
2015 Jensen D, Reynolds N, Yang YP, Shakya S, Wang ZQ, Stuehr DJ, Wei CC. The exchanged EF-hands in calmodulin and troponin C chimeras impair the Ca²⁺-induced hydrophobicity and alter the interaction with Orai1: a spectroscopic, thermodynamic and kinetic study. Bmc Biochemistry. 16: 6. PMID 25888318 DOI: 10.1186/S12858-015-0036-7  0.377
2015 Zhang H, Amick J, Chakravarti R, Santarriaga S, Schlanger S, McGlone C, Dare M, Nix JC, Scaglione KM, Stuehr DJ, Misra S, Page RC. A bipartite interaction between Hsp70 and CHIP regulates ubiquitination of chaperoned client proteins. Structure (London, England : 1993). 23: 472-82. PMID 25684577 DOI: 10.1016/J.Str.2015.01.003  0.429
2015 Chakravarti R, Gupta K, Majors A, Ruple L, Aronica M, Stuehr DJ. Novel insights in mammalian catalase heme maturation: EFFect of NO and thioredoxin-1. Free Radical Biology & Medicine. 82: 105-13. PMID 25659933 DOI: 10.1016/J.Freeradbiomed.2015.01.030  0.492
2015 Hannibal L, Page RC, Haque MM, Bolisetty K, Yu Z, Misra S, Stuehr DJ. Dissecting structural and electronic effects in inducible nitric oxide synthase. The Biochemical Journal. 467: 153-65. PMID 25608846 DOI: 10.1042/Bj20141319  0.535
2015 Stuehr DJ, Ghosh A, Koziol-White CJ, Asosingh K, Cheng G, Ruple L, Rodgers J, Groneberg D, Friebe A, Stasch J, Panettieri RA, Aronical MA, Erzurum SC. sGC redox regulation and asthma Bmc Pharmacology and Toxicology. 16. DOI: 10.1186/2050-6511-16-S1-A26  0.364
2015 Okamoto T, Wheeler D, Chakravarti R, Liu Q, Janocha A, Laskowski D, Quintini C, Stuehr D, Erzurum S, Dweik R, McCurry K. Treatment With Sodium Nitrite Improves the Pulmonary Function of Rejected Human Lungs in Cellular Ex Vivo Lung Perfusion Model The Journal of Heart and Lung Transplantation. 34: S139. DOI: 10.1016/J.Healun.2015.01.374  0.324
2014 Haque MM, Bayachou M, Tejero J, Kenney CT, Pearl NM, Im SC, Waskell L, Stuehr DJ. Distinct conformational behaviors of four mammalian dual-flavin reductases (cytochrome P450 reductase, methionine synthase reductase, neuronal nitric oxide synthase, endothelial nitric oxide synthase) determine their unique catalytic profiles Febs Journal. 281: 5325-5340. PMID 25265015 DOI: 10.1111/Febs.13073  0.518
2014 Revsbech IG, Shen X, Chakravarti R, Jensen FB, Thiel B, Evans AL, Kindberg J, Fröbert O, Stuehr DJ, Kevil CG, Fago A. Hydrogen sulfide and nitric oxide metabolites in the blood of free-ranging brown bears and their potential roles in hibernation. Free Radical Biology & Medicine. 73: 349-57. PMID 24909614 DOI: 10.1016/j.freeradbiomed.2014.05.025  0.374
2014 Ghosh A, Stasch JP, Papapetropoulos A, Stuehr DJ. Nitric oxide and heat shock protein 90 activate soluble guanylate cyclase by driving rapid change in its subunit interactions and heme content. The Journal of Biological Chemistry. 289: 15259-71. PMID 24733395 DOI: 10.1074/jbc.M114.559393  0.448
2014 Arakawa Y, Qin J, Chou HS, Bhatt S, Wang L, Stuehr D, Ghosh A, Fung JJ, Lu L, Qian S. Cotransplantation with myeloid-derived suppressor cells protects cell transplants: a crucial role of inducible nitric oxide synthase. Transplantation. 97: 740-7. PMID 24642686 DOI: 10.1097/01.Tp.0000442504.23885.F7  0.438
2014 Wang Z(, Mahfuzul Haque M, Stuehr D. Catalytic properties of nitric oxide synthase chimeras Nitric Oxide. 42: 150-151. DOI: 10.1016/J.Niox.2014.09.150  0.515
2014 Ramasamy S, Haque MM, Tejero J, Gangoda M, Stuehr D. Probing the mechanism of tetrahydrobiopterin radical reduction within NO synthases Nitric Oxide. 42: 138-139. DOI: 10.1016/J.Niox.2014.09.118  0.401
2014 Hannibal L, Dai Y, Haque MM, Ghosh A, Sarkar A, Stuehr D. Preferential binding of heat shock protein 90 to heme-free soluble guanylate cyclase enables maturation Nitric Oxide. 42: 125. DOI: 10.1016/J.Niox.2014.09.080  0.415
2014 Hannibal L, Page R, Bolisetty K, Yu Z, Misra S, Stuehr D. Electronic and structural features of inducible nitric oxide synthase substituted with mesoheme Nitric Oxide. 42: 125. DOI: 10.1016/J.Niox.2014.09.079  0.492
2014 Dai Y, Stuehr D, Mahfuzul Haque M, Durra D. Conformational changes of neuronal nitric-oxide synthase reductase are essential for electron transfer Nitric Oxide. 42: 119. DOI: 10.1016/J.Niox.2014.09.062  0.478
2014 Chakravarti R, Gupta K, Majors A, Ruple L, Aronica M, Stuehr D. NO and denitrosylases regulate maturation of active catalase by influencing its heme incorporation and tetrameric structure Nitric Oxide. 42: 117. DOI: 10.1016/J.Niox.2014.09.057  0.406
2014 Altawallbeh G, Verdi C, Mahfuzul Haque M, Stuehr D, Bayachou M. Endothelial nitric oxide synthase (eNOS) on lipid nanodiscs: Toward a soluble assembly reflecting native-like function of eNOS Nitric Oxide. 42: 114-115. DOI: 10.1016/J.Niox.2014.09.049  0.474
2014 Okamoto T, Wheeler D, Liu Q, Chakravarti R, Janocha A, Dan L, Cristiano Q, Stuehr D, Erzurum S, Dweik R, McCurry K. Pre-clinical treatment with sodium nitrite improves the pulmonary function of rejected human lungs in an ex vivo lung perfusion model Nitric Oxide. 42: 110. DOI: 10.1016/J.Niox.2014.09.036  0.32
2014 Mahfuzul Haque M, Ray SS, Bayachou M, Stuehr D. Charge pairing and phosphorylation regulate the conformational equilibrium and switching rates in neuronal and endothelial NO synthase flavoprotein domains Nitric Oxide. 42: 107. DOI: 10.1016/J.Niox.2014.09.029  0.38
2014 Majors A, Subramanian A, Ruple L, Chakravarti R, Comhair S, Leahy R, Erzurum S, Stuehr D, Aronica M. Nitric oxide alters hyaluronan deposition by cultured airway smooth muscle cells and correlates with hyaluronan levels in asthmatics Nitric Oxide. 42: 99. DOI: 10.1016/J.Niox.2014.09.007  0.424
2013 Benson MA, Batchelor H, Chuaiphichai S, Bailey J, Zhu H, Stuehr DJ, Bhattacharya S, Channon KM, Crabtree MJ. A pivotal role for tryptophan 447 in enzymatic coupling of human endothelial nitric oxide synthase (eNOS): effects on tetrahydrobiopterin-dependent catalysis and eNOS dimerization. The Journal of Biological Chemistry. 288: 29836-45. PMID 23965989 DOI: 10.1074/Jbc.M113.493023  0.537
2013 Haque MM, Tejero J, Bayachou M, Wang ZQ, Fadlalla M, Stuehr DJ. Thermodynamic characterization of five key kinetic parameters that define neuronal nitric oxide synthase catalysis. The Febs Journal. 280: 4439-53. PMID 23789902 DOI: 10.1111/Febs.12404  0.423
2013 Nagpal L, Haque MM, Saha A, Mukherjee N, Ghosh A, Ranu BC, Stuehr DJ, Panda K. Mechanism of inducible nitric-oxide synthase dimerization inhibition by novel pyrimidine imidazoles. The Journal of Biological Chemistry. 288: 19685-97. PMID 23696643 DOI: 10.1074/Jbc.M112.446542  0.662
2013 Tejero J, Stuehr D. Tetrahydrobiopterin in nitric oxide synthase. Iubmb Life. 65: 358-65. PMID 23441062 DOI: 10.1002/Iub.1136  0.541
2013 Haque MM, Bayachou M, Fadlalla MA, Durra D, Stuehr DJ. Charge-pairing interactions control the conformational setpoint and motions of the FMN domain in neuronal nitric oxide synthase. The Biochemical Journal. 450: 607-17. PMID 23289611 DOI: 10.1042/Bj20121488  0.461
2013 Sabat J, Egawa T, Lu C, Stuehr DJ, Gerfen GJ, Rousseau DL, Yeh SR. Catalytic intermediates of inducible nitric-oxide synthase stabilized by the W188H mutation. The Journal of Biological Chemistry. 288: 6095-106. PMID 23269673 DOI: 10.1074/Jbc.M112.403238  0.488
2013 McKenna KC, Beatty KM, Scherder RC, Li F, Liu H, Chen AF, Ghosh A, Stuehr DJ. Ascorbate in aqueous humor augments nitric oxide production by macrophages. Journal of Immunology (Baltimore, Md. : 1950). 190: 556-64. PMID 23241881 DOI: 10.4049/Jimmunol.1201754  0.453
2013 Stuehr D, Ghosh A, Sarkar A, Dai Y. Mechanisms driving heme insertion into apo-sGC during its maturation in cells Bmc Pharmacology and Toxicology. 14. DOI: 10.1186/2050-6511-14-S1-O18  0.484
2013 Chakravarti R, Gupta K, Svensson L, Roselli E, Pettersson G, Johnston D, Soltesz E, Daly T, Stuehr D, Hoffman G. 14-3-3 in large vessel vasculitis: A novel antigen La Presse MéDicale. 42: 720. DOI: 10.1016/j.lpm.2013.02.161  0.192
2013 Hannibal L, Dai Y, Ghosh A, Sarkar A, Stuehr DJ. Preferential Binding of Heat Shock Protein 90 to Heme-Free Soluble Guanylate Cyclase Enables Maturation Free Radical Biology and Medicine. 65: S90. DOI: 10.1016/J.Freeradbiomed.2013.10.610  0.415
2012 Hannibal L, Collins D, Brassard J, Chakravarti R, Vempati R, Dorlet P, Santolini J, Dawson JH, Stuehr DJ. Heme binding properties of glyceraldehyde-3-phosphate dehydrogenase. Biochemistry. 51: 8514-29. PMID 22957700 DOI: 10.1021/Bi300863A  0.496
2012 Ghosh A, Stuehr DJ. Soluble guanylyl cyclase requires heat shock protein 90 for heme insertion during maturation of the NO-active enzyme. Proceedings of the National Academy of Sciences of the United States of America. 109: 12998-3003. PMID 22837396 DOI: 10.1073/Pnas.1205854109  0.471
2012 Jia J, Arif A, Willard B, Smith JD, Stuehr DJ, Hazen SL, Fox PL. Protection of extraribosomal RPL13a by GAPDH and dysregulation by S-nitrosylation. Molecular Cell. 47: 656-63. PMID 22771119 DOI: 10.1016/J.Molcel.2012.06.006  0.454
2012 Haque MM, Fadlalla MA, Aulak KS, Ghosh A, Durra D, Stuehr DJ. Control of electron transfer and catalysis in neuronal nitric-oxide synthase (nNOS) by a hinge connecting its FMN and FAD-NADPH domains. The Journal of Biological Chemistry. 287: 30105-16. PMID 22722929 DOI: 10.1074/Jbc.M112.339697  0.511
2012 Wei CC, Reynolds N, Palka C, Wetherell K, Boyle T, Yang YP, Wang ZQ, Stuehr DJ. Characterization of the 1st and 2nd EF-hands of NADPH oxidase 5 by fluorescence, isothermal titration calorimetry, and circular dichroism. Chemistry Central Journal. 6: 29. PMID 22490336 DOI: 10.1186/1752-153X-6-29  0.408
2012 Chakravarti R, Stuehr DJ. Thioredoxin-1 regulates cellular heme insertion by controlling S-nitrosation of glyceraldehyde-3-phosphate dehydrogenase. The Journal of Biological Chemistry. 287: 16179-86. PMID 22457359 DOI: 10.1074/Jbc.M112.342758  0.492
2012 Wang ZQ, Tejero J, Wei CC, Haque MM, Santolini J, Fadlalla M, Biswas A, Stuehr DJ. Arg375 tunes tetrahydrobiopterin functions and modulates catalysis by inducible nitric oxide synthase. Journal of Inorganic Biochemistry. 108: 203-15. PMID 22173094 DOI: 10.1016/J.Jinorgbio.2011.11.015  0.7
2012 Salard-Arnaud I, Stuehr D, Boucher JL, Mansuy D. Spectroscopic, catalytic and binding properties of Bacillus subtilis NO synthase-like protein: Comparison with other bacterial and mammalian NO synthases Journal of Inorganic Biochemistry. 106: 164-171. PMID 22119809 DOI: 10.1016/J.Jinorgbio.2011.10.003  0.527
2012 Qin J, Arasawa Y, Chou H, Wang L, Stuehr D, Ghosh A, Fung JJ, Qian S, Lu L. Myeloid Suppressor Cells Protect Islet Allografts through iNOS-Mediated T Cell Inhibition Transplantation Journal. 94: 201. DOI: 10.1097/00007890-201211271-00375  0.282
2012 Nagpal L, Haque MM, Ghosh A, Saha A, Mukherjee N, Ranu BC, Stuehr DJ, Panda K. Mechanism of nitric oxide synthase dimerization inhibition by novel pyrimidine imidazoles Nitric Oxide. 27: S34-S35. DOI: 10.1016/J.Niox.2012.04.123  0.624
2012 Stuehr D, Chakravarti R, Ghosh A, Hannibal L. Post-translational heme insertion into NOS and related enzymes Nitric Oxide. 27: S5. DOI: 10.1016/J.Niox.2012.04.020  0.55
2012 Hannibal L, Page R, Bolisetty K, Yu Z, Misra S, Stuehr DJ. Kinetic and Structural Characterization of Inducible Nitric Oxide Synthase Substituted with Mesoheme Free Radical Biology and Medicine. 53: S148. DOI: 10.1016/J.Freeradbiomed.2012.10.401  0.521
2011 Hannibal L, Somasundaram R, Tejero J, Wilson A, Stuehr DJ. Influence of heme-thiolate in shaping the catalytic properties of a bacterial nitric-oxide synthase. The Journal of Biological Chemistry. 286: 39224-35. PMID 21921039 DOI: 10.1074/Jbc.M111.286351  0.571
2011 Haque MM, Kenney C, Tejero J, Stuehr DJ. A kinetic model linking protein conformational motions, interflavin electron transfer and electron flux through a dual-flavin enzyme-simulating the reductase activity of the endothelial and neuronal nitric oxide synthase flavoprotein domains. The Febs Journal. 278: 4055-69. PMID 21848659 DOI: 10.1111/J.1742-4658.2011.08310.X  0.485
2011 Ghosh A, Chawla-Sarkar M, Stuehr DJ. Hsp90 interacts with inducible NO synthase client protein in its heme-free state and then drives heme insertion by an ATP-dependent process. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 2049-60. PMID 21357526 DOI: 10.1096/Fj.10-180554  0.515
2011 Tejero J, Biswas A, Haque MM, Wang ZQ, Hemann C, Varnado CL, Novince Z, Hille R, Goodwin DC, Stuehr DJ. Mesohaem substitution reveals how haem electronic properties can influence the kinetic and catalytic parameters of neuronal NO synthase. The Biochemical Journal. 433: 163-74. PMID 20950274 DOI: 10.1042/Bj20101353  0.69
2010 Chakravarti R, Aulak KS, Fox PL, Stuehr DJ. GAPDH regulates cellular heme insertion into inducible nitric oxide synthase. Proceedings of the National Academy of Sciences of the United States of America. 107: 18004-9. PMID 20921417 DOI: 10.1073/Pnas.1008133107  0.565
2010 Maréchal A, Mattioli TA, Stuehr DJ, Santolini J. NO synthase isoforms specifically modify peroxynitrite reactivity. The Febs Journal. 277: 3963-73. PMID 20840589 DOI: 10.1111/J.1742-4658.2010.07786.X  0.564
2010 Wei CC, Motl N, Levek K, Chen LQ, Yang YP, Johnson T, Hamilton L, Stuehr DJ. Conformational States and kinetics of the calcium binding domain of NADPH oxidase 5. The Open Biochemistry Journal. 4: 59-67. PMID 20648216 DOI: 10.2174/1874091X01004010059  0.42
2010 Tejero J, Hannibal L, Mustovich A, Stuehr DJ. Surface charges and regulation of FMN to heme electron transfer in nitric-oxide synthase. The Journal of Biological Chemistry. 285: 27232-40. PMID 20592038 DOI: 10.1074/Jbc.M110.138842  0.496
2010 Tejero J, Haque MM, Durra D, Stuehr DJ. A bridging interaction allows calmodulin to activate NO synthase through a bi-modal mechanism. The Journal of Biological Chemistry. 285: 25941-9. PMID 20529840 DOI: 10.1074/Jbc.M110.126797  0.472
2010 Waheed SM, Ghosh A, Chakravarti R, Biswas A, Haque MM, Panda K, Stuehr DJ. Nitric oxide blocks cellular heme insertion into a broad range of heme proteins. Free Radical Biology & Medicine. 48: 1548-58. PMID 20211245 DOI: 10.1016/J.Freeradbiomed.2010.02.038  0.706
2010 Wang ZQ, Wei CC, Stuehr DJ. How does a valine residue that modulates heme-NO binding kinetics in inducible NO synthase regulate enzyme catalysis? Journal of Inorganic Biochemistry. 104: 349-56. PMID 20006999 DOI: 10.1016/J.Jinorgbio.2009.11.006  0.53
2010 Giroud C, Moreau M, Mattioli TA, Balland V, Boucher JL, Xu-Li Y, Stuehr DJ, Santolini J. Role of arginine guanidinium moiety in nitric-oxide synthase mechanism of oxygen activation. The Journal of Biological Chemistry. 285: 7233-45. PMID 19951943 DOI: 10.1074/Jbc.M109.038240  0.554
2010 Guan ZW, Haque MM, Wei CC, Garcin ED, Getzoff ED, Stuehr DJ. Lys842 in neuronal nitric-oxide synthase enables the autoinhibitory insert to antagonize calmodulin binding, increase FMN shielding, and suppress interflavin electron transfer. The Journal of Biological Chemistry. 285: 3064-75. PMID 19948738 DOI: 10.1074/Jbc.M109.000810  0.533
2010 Hannibal L, Santolini J, Stuehr DJ. Role of a Proximal Trp Residue in Catalysis by Bacterial and Mammalian NOS: Differences and Similarities Free Radical Biology and Medicine. 49: S210-S211. DOI: 10.1016/J.Freeradbiomed.2010.10.612  0.429
2010 FELDMAN PL, CHI S, SENNEQUIER N, STUEHR DJ. ChemInform Abstract: Synthesis of the L-Arginine Congener L-Indospicine and Evaluation of Its Interaction with Nitric Oxide Synthase. Cheminform. 27: no-no. DOI: 10.1002/CHIN.199617204  0.379
2009 Tejero J, Santolini J, Stuehr DJ. Fast ferrous heme-NO oxidation in nitric oxide synthases. The Febs Journal. 276: 4505-14. PMID 19691141 DOI: 10.1111/J.1742-4658.2009.07157.X  0.551
2009 Sabat J, Stuehr DJ, Yeh SR, Rousseau DL. Characterization of the proximal ligand in the P420 form of inducible nitric oxide synthase. Journal of the American Chemical Society. 131: 12186-92. PMID 19658411 DOI: 10.1021/Ja901016A  0.487
2009 Stuehr DJ, Tejero J, Haque MM. Structural and mechanistic aspects of flavoproteins: electron transfer through the nitric oxide synthase flavoprotein domain. The Febs Journal. 276: 3959-74. PMID 19583767 DOI: 10.1111/J.1742-4658.2009.07120.X  0.507
2009 Haque MM, Fadlalla M, Wang ZQ, Ray SS, Panda K, Stuehr DJ. Neutralizing a surface charge on the FMN subdomain increases the activity of neuronal nitric-oxide synthase by enhancing the oxygen reactivity of the enzyme heme-nitric oxide complex. The Journal of Biological Chemistry. 284: 19237-47. PMID 19473991 DOI: 10.1074/Jbc.M109.013144  0.509
2009 Koeck T, Corbett JA, Crabb JW, Stuehr DJ, Aulak KS. Glucose-modulated tyrosine nitration in beta cells: targets and consequences. Archives of Biochemistry and Biophysics. 484: 221-31. PMID 19402213 DOI: 10.1016/J.Abb.2009.01.021  0.431
2009 Ilagan RP, Tejero J, Aulak KS, Ray SS, Hemann C, Wang ZQ, Gangoda M, Zweier JL, Stuehr DJ. Regulation of FMN subdomain interactions and function in neuronal nitric oxide synthase. Biochemistry. 48: 3864-76. PMID 19290671 DOI: 10.1021/Bi8021087  0.544
2009 Fan B, Stuehr DJ, Rousseau DL. Role of substrate functional groups in binding to nitric oxide synthase. Biochemical and Biophysical Research Communications. 382: 21-5. PMID 19248772 DOI: 10.1016/J.Bbrc.2009.02.084  0.474
2009 Koeck T, Willard B, Crabb JW, Kinter M, Stuehr DJ, Aulak KS. Glucose-mediated tyrosine nitration in adipocytes: targets and consequences. Free Radical Biology & Medicine. 46: 884-92. PMID 19135148 DOI: 10.1016/J.Freeradbiomed.2008.12.010  0.435
2009 Wegrzyn J, Potla R, Chwae YJ, Sepuri NB, Zhang Q, Koeck T, Derecka M, Szczepanek K, Szelag M, Gornicka A, Moh A, Moghaddas S, Chen Q, Bobbili S, Cichy J, ... ... Stuehr D, et al. Function of mitochondrial Stat3 in cellular respiration. Science (New York, N.Y.). 323: 793-7. PMID 19131594 DOI: 10.1126/Science.1164551  0.415
2008 Garcin ED, Arvai AS, Rosenfeld RJ, Kroeger MD, Crane BR, Andersson G, Andrews G, Hamley PJ, Mallinder PR, Nicholls DJ, St-Gallay SA, Tinker AC, Gensmantel NP, Mete A, Cheshire DR, ... ... Stuehr DJ, et al. Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Nature Chemical Biology. 4: 700-7. PMID 18849972 DOI: 10.1038/Nchembio.115  0.493
2008 Tejero J, Biswas A, Wang ZQ, Page RC, Haque MM, Hemann C, Zweier JL, Misra S, Stuehr DJ. Stabilization and characterization of a heme-oxy reaction intermediate in inducible nitric-oxide synthase. The Journal of Biological Chemistry. 283: 33498-507. PMID 18815130 DOI: 10.1074/Jbc.M806122200  0.712
2008 Donzelli S, Espey MG, Flores-Santana W, Switzer CH, Yeh GC, Huang J, Stuehr DJ, King SB, Miranda KM, Wink DA. Generation of nitroxyl by heme protein-mediated peroxidation of hydroxylamine but not N-hydroxy-L-arginine. Free Radical Biology & Medicine. 45: 578-84. PMID 18503778 DOI: 10.1016/J.Freeradbiomed.2008.04.036  0.564
2008 Cottyn B, Acher F, Ramassamy B, Alvey L, Lepoivre M, Frapart Y, Stuehr D, Mansuy D, Boucher JL, Vichard D. Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: Particular potency of 1H-indazole-7-carbonitrile Bioorganic and Medicinal Chemistry. 16: 5962-5973. PMID 18502134 DOI: 10.1016/J.Bmc.2008.04.056  0.496
2008 Ilagan RP, Tiso M, Konas DW, Hemann C, Durra D, Hille R, Stuehr DJ. Differences in a conformational equilibrium distinguish catalysis by the endothelial and neuronal nitric-oxide synthase flavoproteins. The Journal of Biological Chemistry. 283: 19603-15. PMID 18487202 DOI: 10.1074/Jbc.M802914200  0.523
2008 Chandor A, Dijols S, Ramassamy B, Frapart Y, Mansuy D, Stuehr D, Helsby N, Boucher JL. Metabolic activation of the antitumor drug 5-(aziridin-1-yl)-2,4- dinitrobenzamide (CB1954) by NO synthases Chemical Research in Toxicology. 21: 836-843. PMID 18370414 DOI: 10.1021/Tx7004234  0.563
2008 Gusarov I, Starodubtseva M, Wang ZQ, McQuade L, Lippard SJ, Stuehr DJ, Nudler E. Bacterial nitric-oxide synthases operate without a dedicated redox partner. The Journal of Biological Chemistry. 283: 13140-7. PMID 18316370 DOI: 10.1074/Jbc.M710178200  0.515
2008 Wei CC, Wang ZQ, Tejero J, Yang YP, Hemann C, Hille R, Stuehr DJ. Catalytic reduction of a tetrahydrobiopterin radical within nitric-oxide synthase. The Journal of Biological Chemistry. 283: 11734-42. PMID 18283102 DOI: 10.1074/Jbc.M709250200  0.489
2008 Tiso M, Strub A, Hesslinger C, Kenney CT, Boer R, Stuehr DJ. BYK191023 (2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3h-imidazo[4,5-b]pyridine) is an NADPH- and time-dependent irreversible inhibitor of inducible nitric-oxide synthase. Molecular Pharmacology. 73: 1244-53. PMID 18178668 DOI: 10.1124/Mol.107.041319  0.538
2008 Gusarov I, Starodubtseva M, Wang ZQ, McQuade L, Lippard SJ, Stuehr DJ, Nudler E. Bacterial nitric-oxide synthases operate without a dedicated redox partner (Journal of Biological Chemistry (2008) 283, (13140-13147)) Journal of Biological Chemistry. 283: 19164. DOI: 10.1074/jbc.M710178200  0.395
2008 Koeck T, Corbett JA, Crabb JW, Stuehr DJ, Aulak KS. P77. Glucose-triggered protein tyrosine nitration in β-cells: Targets and consequences Nitric Oxide. 19: 60-61. DOI: 10.1016/J.Niox.2008.06.175  0.364
2008 Cottyn B, Boucher J, Acher F, Lepoivre M, Stuehr D, Mansuy D, Vichard D. O63. Inhibitory effects of a series of 7-substituted-indazoles towards nitric oxide synthases Nitric Oxide. 19: 34. DOI: 10.1016/J.Niox.2008.06.064  0.482
2008 Giroud C, Boucher J, Stuehr D, Balland V, Santolini J. O24. Key role of pKa of guanidines in the mechanism of NO synthase Nitric Oxide. 19: 25. DOI: 10.1016/J.Niox.2008.06.025  0.38
2007 Tiso M, Tejero J, Panda K, Aulak KS, Stuehr DJ. Versatile regulation of neuronal nitric oxide synthase by specific regions of its C-terminal tail. Biochemistry. 46: 14418-28. PMID 18020458 DOI: 10.1021/Bi701646K  0.464
2007 Beaumont E, Lambry JC, Wang ZQ, Stuehr DJ, Martin JL, Slama-Schwok A. Distal Val346Ile mutation in inducible NO synthase promotes substrate-dependent NO confinement. Biochemistry. 46: 13533-40. PMID 17973404 DOI: 10.1021/Bi701567H  0.47
2007 Erzurum SC, Ghosh S, Janocha AJ, Xu W, Bauer S, Bryan NS, Tejero J, Hemann C, Hille R, Stuehr DJ, Feelisch M, Beall CM. Higher blood flow and circulating NO products offset high-altitude hypoxia among Tibetans. Proceedings of the National Academy of Sciences of the United States of America. 104: 17593-8. PMID 17971439 DOI: 10.1073/Pnas.0707462104  0.372
2007 Ray SS, Sengupta R, Tiso M, Haque MM, Sahoo R, Konas DW, Aulak K, Regulski M, Tully T, Stuehr DJ, Ghosh S. Reductase domain of Drosophila melanogaster nitric-oxide synthase: redox transformations, regulation, and similarity to mammalian homologues. Biochemistry. 46: 11865-73. PMID 17900149 DOI: 10.1021/Bi700805X  0.553
2007 Ray SS, Tejero J, Wang ZQ, Dutta T, Bhattacharjee A, Regulski M, Tully T, Ghosh S, Stuehr DJ. Oxygenase domain of Drosophila melanogaster nitric oxide synthase: unique kinetic parameters enable a more efficient NO release. Biochemistry. 46: 11857-64. PMID 17900148 DOI: 10.1021/Bi700803P  0.554
2007 Haque MM, Panda K, Tejero J, Aulak KS, Fadlalla MA, Mustovich AT, Stuehr DJ. A connecting hinge represses the activity of endothelial nitric oxide synthase. Proceedings of the National Academy of Sciences of the United States of America. 104: 9254-9. PMID 17517617 DOI: 10.1073/Pnas.0700332104  0.546
2007 Li D, Kabir M, Stuehr DJ, Rousseau DL, Yeh SR. Substrate- and isoform-specific dioxygen complexes of nitric oxide synthase. Journal of the American Chemical Society. 129: 6943-51. PMID 17488012 DOI: 10.1021/Ja070683J  0.486
2007 Maréchal A, Mattioli TA, Stuehr DJ, Santolini J. Activation of peroxynitrite by inducible nitric-oxide synthase: a direct source of nitrative stress. The Journal of Biological Chemistry. 282: 14101-12. PMID 17369257 DOI: 10.1074/Jbc.M609237200  0.563
2007 Xu W, Koeck T, Lara AR, Neumann D, DiFilippo FP, Koo M, Janocha AJ, Masri FA, Arroliga AC, Jennings C, Dweik RA, Tuder RM, Stuehr DJ, Erzurum SC. Alterations of cellular bioenergetics in pulmonary artery endothelial cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 1342-7. PMID 17227868 DOI: 10.1073/Pnas.0605080104  0.416
2007 Jagnandan D, Church JE, Banfi B, Stuehr DJ, Marrero MB, Fulton DJ. Novel mechanism of activation of NADPH oxidase 5. calcium sensitization via phosphorylation. The Journal of Biological Chemistry. 282: 6494-507. PMID 17164239 DOI: 10.1074/Jbc.M608966200  0.422
2007 Wang ZQ, Lawson RJ, Buddha MR, Wei CC, Crane BR, Munro AW, Stuehr DJ. Bacterial flavodoxins support nitric oxide production by Bacillus subtilis nitric-oxide synthase. The Journal of Biological Chemistry. 282: 2196-202. PMID 17127770 DOI: 10.1074/Jbc.M608206200  0.544
2006 Konas DW, Takaya N, Sharma M, Stuehr DJ. Role of Asp1393 in catalysis, flavin reduction, NADP(H) binding, FAD thermodynamics, and regulation of the nNOS flavoprotein. Biochemistry. 45: 12596-609. PMID 17029414 DOI: 10.1021/Bi061011T  0.547
2006 Panda K, Haque MM, Garcin-Hosfield ED, Durra D, Getzoff ED, Stuehr DJ. Surface charge interactions of the FMN module govern catalysis by nitric-oxide synthase. The Journal of Biological Chemistry. 281: 36819-27. PMID 17001078 DOI: 10.1074/Jbc.M606129200  0.494
2006 Potla R, Koeck T, Wegrzyn J, Cherukuri S, Shimoda K, Baker DP, Wolfman J, Planchon SM, Esposito C, Hoit B, Dulak J, Wolfman A, Stuehr D, Larner AC. Tyk2 tyrosine kinase expression is required for the maintenance of mitochondrial respiration in primary pro-B lymphocytes Molecular and Cellular Biology. 26: 8562-8571. PMID 16982690 DOI: 10.1128/Mcb.00497-06  0.411
2006 Moreau M, Boucher JL, Mattioli TA, Stuehr DJ, Mansuy D, Santolini J. Differential effects of alkyl- and arylguanidines on the stability and reactivity of inducible NOS heme-dioxygen complexes Biochemistry. 45: 3988-3999. PMID 16548526 DOI: 10.1021/Bi051488P  0.469
2006 Santolini J, Roman M, Stuehr DJ, Mattioli TA. Resonance Raman study of Bacillus subtilis NO synthase-like protein: similarities and differences with mammalian NO synthases. Biochemistry. 45: 1480-9. PMID 16445290 DOI: 10.1021/Bi051710Q  0.453
2006 Li D, Hayden EY, Panda K, Stuehr DJ, Deng H, Rousseau DL, Yeh SR. Regulation of the monomer-dimer equilibrium in inducible nitric-oxide synthase by nitric oxide. The Journal of Biological Chemistry. 281: 8197-204. PMID 16421101 DOI: 10.1074/Jbc.M507328200  0.561
2006 Lefèvre-Groboillot D, Boucher JL, Mansuy D, Stuehr DJ. Reactivity of the heme-dioxygen complex of the inducible nitric oxide synthase in the presence of alternative substrates Febs Journal. 273: 180-191. PMID 16367758 DOI: 10.1111/J.1742-4658.2005.05056.X  0.461
2006 Koeck T, Stuehr DJ, Aulak KS. Mitochondria and regulated tyrosine nitration. Biochemical Society Transactions. 33: 1399-403. PMID 16246129 DOI: 10.1042/Bst20051399  0.474
2006 Garcin-Hosfield ED, Arvai AS, Rosenfeld RJ, Bonaventura J, Scharber MA, Bruns CM, Hosfield DJ, Jane Lloyd S, MacCoss MJ, Yates J, Tiso M, Stuehr DJ, Tainer JA, Getzoff ED. P188. Structural insights into NOS regulatory mechanisms: What? where? how? Nitric Oxide. 14: 77-78. DOI: 10.1016/J.Niox.2006.04.258  0.371
2006 Guan Z, Stuehr DJ. P184. Different contribution of FMN and FNR modules to nitric oxide synthase function revealed by chimera enzymes Nitric Oxide. 14: 76-77. DOI: 10.1016/J.Niox.2006.04.254  0.513
2006 Haque MM, Panda K, Garcin-Hosfield ED, Getzoff ED, Stuehr DJ. P181. Charge interactions at the interface of electron transport modules govern catalysis by neuronal nitric-oxide synthase Nitric Oxide. 14: 76. DOI: 10.1016/J.Niox.2006.04.251  0.44
2006 Marechal A, Mattioli TA, Stuehr DJ, Santolini J. P178. NO-synthases and oxidative stress: A novel nitration activity Nitric Oxide. 14: 75. DOI: 10.1016/J.Niox.2006.04.248  0.454
2006 Garcin-Hosfield E, Arvai A, Rosenfeld R, Crane B, Connolly S, Tinker A, Aberg A, Andersson G, Stuehr D, Wallace A, Tainer J, Getzoff E. P0118. Structural insights into the conformational selectivity of inducible nitric oxide synthase specific inhibitors Nitric Oxide. 14: 55. DOI: 10.1016/J.Niox.2006.04.184  0.478
2006 Wang R, Guan Z, Konas D, Tiso M, Stuehr DJ. O47. Structure-function studies regarding NADPH regulation of neuronal NO synthase Nitric Oxide. 14: 15. DOI: 10.1016/J.Niox.2006.04.051  0.383
2006 Konas DW, Takaya N, Tiso M, Panda K, Adak S, Garcin ED, Getzoff ED, Stuehr DJ. O44. How distinct structural elements combine to regulate NOS electron transfer and catalysis Nitric Oxide. 14: 14. DOI: 10.1016/J.Niox.2006.04.048  0.385
2005 Belliston-Bittner W, Dunn AR, Nguyen YH, Stuehr DJ, Winkler JR, Gray HB. Picosecond photoreduction of inducible nitric oxide synthase by rhenium(I)-diimine wires. Journal of the American Chemical Society. 127: 15907-15. PMID 16277534 DOI: 10.1021/Ja0543088  0.525
2005 Stuehr DJ, Wei CC, Wang Z, Hille R. Exploring the redox reactions between heme and tetrahydrobiopterin in the nitric oxide synthases. Dalton Transactions (Cambridge, England : 2003). 3427-35. PMID 16234921 DOI: 10.1039/B506355H  0.49
2005 Tiso M, Konas DW, Panda K, Garcin ED, Sharma M, Getzoff ED, Stuehr DJ. C-terminal tail residue Arg1400 enables NADPH to regulate electron transfer in neuronal nitric-oxide synthase. The Journal of Biological Chemistry. 280: 39208-19. PMID 16150731 DOI: 10.1074/Jbc.M507775200  0.453
2005 Panda K, Chawla-Sarkar M, Santos C, Koeck T, Erzurum SC, Parkinson JF, Stuehr DJ. Visualizing inducible nitric-oxide synthase in living cells with a heme-binding fluorescent inhibitor. Proceedings of the National Academy of Sciences of the United States of America. 102: 10117-22. PMID 16006534 DOI: 10.1073/Pnas.0408972102  0.484
2005 Lefèvre-Groboillot D, Boucher JL, Stuehr DJ, Mansuy D. Relationship between the structure of guanidines and N-hydroxyguanidines, their binding to inducible nitric oxide synthase (iNOS) and their iNOS-catalysed oxidation to NO Febs Journal. 272: 3172-3183. PMID 15955074 DOI: 10.1111/J.1742-4658.2005.04736.X  0.494
2005 Masri FA, Comhair SA, Koeck T, Xu W, Janocha A, Ghosh S, Dweik RA, Golish J, Kinter M, Stuehr DJ, Erzurum SC, Aulak KS. Abnormalities in nitric oxide and its derivatives in lung cancer. American Journal of Respiratory and Critical Care Medicine. 172: 597-605. PMID 15947282 DOI: 10.1164/Rccm.200411-1523Oc  0.48
2005 Dunn AR, Belliston-Bittner W, Winkler JR, Getzoff ED, Stuehr DJ, Gray HB. Luminescent ruthenium(II)- and rhenium(I)-diimine wires bind nitric oxide synthase. Journal of the American Chemical Society. 127: 5169-73. PMID 15810851 DOI: 10.1021/Ja046971M  0.531
2005 Jeng BH, Shadrach KG, Meisler DM, Hollyfield JG, Connor JT, Koeck T, Aulak KS, Stuehr DJ. Immunohistochemical detection and Western blot analysis of nitrated protein in stored human corneal epithelium. Experimental Eye Research. 80: 509-14. PMID 15781278 DOI: 10.1016/J.Exer.2004.10.015  0.39
2005 Wang ZQ, Wei CC, Santolini J, Panda K, Wang Q, Stuehr DJ. A tryptophan that modulates tetrahydrobiopterin-dependent electron transfer in nitric oxide synthase regulates enzyme catalysis by additional mechanisms. Biochemistry. 44: 4676-90. PMID 15779894 DOI: 10.1021/Bi047508P  0.543
2005 Wei CC, Wang ZQ, Durra D, Hemann C, Hille R, Garcin ED, Getzoff ED, Stuehr DJ. The three nitric-oxide synthases differ in their kinetics of tetrahydrobiopterin radical formation, heme-dioxy reduction, and arginine hydroxylation. The Journal of Biological Chemistry. 280: 8929-35. PMID 15632185 DOI: 10.1074/Jbc.M409737200  0.517
2004 Stuehr DJ, Wei CC, Santolini J, Wang Z, Aoyagi M, Getzoff ED. Radical reactions of nitric oxide synthases. Biochemical Society Symposium. 39-49. PMID 15777011 DOI: 10.1042/Bss0710039  0.541
2004 Stuehr DJ. Enzymes of the L-arginine to nitric oxide pathway. The Journal of Nutrition. 134: 2748S-2751S; discuss. PMID 15465779 DOI: 10.1093/Jn/134.10.2748S  0.522
2004 Garcin ED, Bruns CM, Lloyd SJ, Hosfield DJ, Tiso M, Gachhui R, Stuehr DJ, Tainer JA, Getzoff ED. Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase. The Journal of Biological Chemistry. 279: 37918-27. PMID 15208315 DOI: 10.1074/Jbc.M406204200  0.523
2004 Aulak KS, Koeck T, Crabb JW, Stuehr DJ. Proteomic method for identification of tyrosine-nitrated proteins. Methods in Molecular Biology (Clifton, N.J.). 279: 151-65. PMID 15199243 DOI: 10.1385/1-59259-807-2:151  0.374
2004 Konas DW, Zhu K, Sharma M, Aulak KS, Brudvig GW, Stuehr DJ. The FAD-shielding residue Phe1395 regulates neuronal nitric-oxide synthase catalysis by controlling NADP+ affinity and a conformational equilibrium within the flavoprotein domain. The Journal of Biological Chemistry. 279: 35412-25. PMID 15180983 DOI: 10.1074/Jbc.M400872200  0.502
2004 Stuehr DJ, Santolini J, Wang ZQ, Wei CC, Adak S. Update on mechanism and catalytic regulation in the NO synthases. The Journal of Biological Chemistry. 279: 36167-70. PMID 15133020 DOI: 10.1074/Jbc.R400017200  0.408
2004 Koeck T, Fu X, Hazen SL, Crabb JW, Stuehr DJ, Aulak KS. Rapid and selective oxygen-regulated protein tyrosine denitration and nitration in mitochondria. The Journal of Biological Chemistry. 279: 27257-62. PMID 15084586 DOI: 10.1074/Jbc.M401586200  0.472
2004 Li D, Stuehr DJ, Yeh SR, Rousseau DL. Heme distortion modulated by ligand-protein interactions in inducible nitric-oxide synthase. The Journal of Biological Chemistry. 279: 26489-99. PMID 15066989 DOI: 10.1074/Jbc.M400968200  0.481
2004 Meisler DM, Koeck T, Connor JT, Aulak KS, Jeng BH, Hollyfield JG, Stuehr DJ, Shadrach KG. Inhibition of nitric oxide synthesis in corneas in storage media. Experimental Eye Research. 78: 891-4. PMID 15037122 DOI: 10.1016/J.Exer.2003.12.009  0.494
2004 Koeck T, Levison B, Hazen SL, Crabb JW, Stuehr DJ, Aulak KS. Tyrosine nitration impairs mammalian aldolase A activity. Molecular & Cellular Proteomics : McP. 3: 548-57. PMID 14978198 DOI: 10.1074/Mcp.M300141-Mcp200  0.471
2004 Wang ZQ, Wei CC, Sharma M, Pant K, Crane BR, Stuehr DJ. A conserved Val to Ile switch near the heme pocket of animal and bacterial nitric-oxide synthases helps determine their distinct catalytic profiles. The Journal of Biological Chemistry. 279: 19018-25. PMID 14976216 DOI: 10.1074/Jbc.M311663200  0.504
2004 Panda K, Adak S, Konas D, Sharma M, Stuehr DJ. A conserved aspartate (Asp-1393) regulates NADPH reduction of neuronal nitric-oxide synthase: implications for catalysis. The Journal of Biological Chemistry. 279: 18323-33. PMID 14966111 DOI: 10.1074/Jbc.M310391200  0.555
2004 Aulak KS, Koeck T, Crabb JW, Stuehr DJ. Dynamics of protein nitration in cells and mitochondria. American Journal of Physiology. Heart and Circulatory Physiology. 286: H30-8. PMID 14684358 DOI: 10.1152/Ajpheart.00743.2003  0.477
2004 Gautier C, Négrerie M, Wang ZQ, Lambry JC, Stuehr DJ, Collin F, Martin JL, Slama-Schwok A. Dynamic regulation of the inducible nitric-oxide synthase by NO: comparison with the endothelial isoform. The Journal of Biological Chemistry. 279: 4358-65. PMID 14594819 DOI: 10.1074/Jbc.M305048200  0.471
2004 Sawa T, Akaike T, Ichimori K, Akuta T, Kaneko K, Nakayama H, Stuehr DJ, Maeda H. Superoxide generation mediated by 8-nitroguanosine, a highly redox-active nucleic acid derivative. Biochemical and Biophysical Research Communications. 311: 300-6. PMID 14592413 DOI: 10.1016/J.Bbrc.2003.10.003  0.501
2003 Ask K, Dijols S, Giroud C, Casse L, Frapart YM, Sari MA, Kim KS, Stuehr DJ, Mansuy D, Camus P, Boucher JL. Reduction of Nilutamide by NO Synthases: Implications for the Adverse Effects of This Nitroaromatic Antiandrogen Drug Chemical Research in Toxicology. 16: 1547-1554. PMID 14680368 DOI: 10.1021/Tx0340910  0.472
2003 Wei CC, Wang ZQ, Hemann C, Hille R, Stuehr DJ. A tetrahydrobiopterin radical forms and then becomes reduced during Nomega-hydroxyarginine oxidation by nitric-oxide synthase. The Journal of Biological Chemistry. 278: 46668-73. PMID 14504282 DOI: 10.1074/Jbc.M307682200  0.554
2003 Panda K, Adak S, Aulak KS, Santolini J, McDonald JF, Stuehr DJ. Distinct influence of N-terminal elements on neuronal nitric-oxide synthase structure and catalysis. The Journal of Biological Chemistry. 278: 37122-31. PMID 12847099 DOI: 10.1074/Jbc.M304456200  0.5
2003 Turko IV, Li L, Aulak KS, Stuehr DJ, Chang JY, Murad F. Protein tyrosine nitration in the mitochondria from diabetic mouse heart. Implications to dysfunctional mitochondria in diabetes. The Journal of Biological Chemistry. 278: 33972-7. PMID 12821649 DOI: 10.1074/jbc.M303734200  0.576
2003 Sengupta R, Sahoo R, Mukherjee S, Regulski M, Tully T, Stuehr DJ, Ghosh S. Characterization of Drosophila nitric oxide synthase: a biochemical study. Biochemical and Biophysical Research Communications. 306: 590-7. PMID 12804606 DOI: 10.1016/S0006-291X(03)01003-9  0.52
2003 Wei CC, Crane BR, Stuehr DJ. Tetrahydrobiopterin radical enzymology. Chemical Reviews. 103: 2365-83. PMID 12797834 DOI: 10.1021/Cr0204350  0.355
2003 Lefèvre-Groboillot D, Frapart Y, Desbois A, Zimmermann JL, Boucher JL, Gorren AC, Mayer B, Stuehr DJ, Mansuy D. Two modes of binding of N-hydroxyguanidines to NO synthases: first evidence for the formation of iron-N-hydroxyguanidine complexes and key role of tetrahydrobiopterin in determining the binding mode. Biochemistry. 42: 3858-67. PMID 12667076 DOI: 10.1021/Bi0272407  0.459
2003 Voegtle HL, Sono M, Adak S, Pond AE, Tomita T, Perera R, Goodin DB, Ikeda-Saito M, Stuehr DJ, Dawson JH. Spectroscopic characterization of five- and six-coordinate ferrous-NO heme complexes. Evidence for heme Fe-proximal cysteinate bond cleavage in the ferrous-NO adducts of the Trp-409Tyr/Phe proximal environment mutants of neuronal nitric oxide synthase. Biochemistry. 42: 2475-84. PMID 12600215 DOI: 10.1021/Bi0271502  0.533
2003 Wei CC, Wang ZQ, Arvai AS, Hemann C, Hille R, Getzoff ED, Stuehr DJ. Structure of tetrahydrobiopterin tunes its electron transfer to the heme-dioxy intermediate in nitric oxide synthase. Biochemistry. 42: 1969-77. PMID 12590583 DOI: 10.1021/Bi026898H  0.449
2003 Wei CC, Wang ZQ, Stuehr DJ. Nitric oxide synthase: use of stopped-flow spectroscopy and rapid-quench methods in single-turnover conditions to examine formation and reactions of heme-O2 intermediate in early catalysis. Methods in Enzymology. 354: 320-38. PMID 12418237 DOI: 10.1016/S0076-6879(02)54026-X  0.491
2003 Wei C, Crane BR, Stuehr DJ. Tetrahydrobiopterin Radical Enzymology Cheminform. 34. DOI: 10.1002/CHIN.200332281  0.249
2002 Rosenfeld RJ, Garcin ED, Panda K, Andersson G, Aberg A, Wallace AV, Morris GM, Olson AJ, Stuehr DJ, Tainer JA, Getzoff ED. Conformational changes in nitric oxide synthases induced by chlorzoxazone and nitroindazoles: crystallographic and computational analyses of inhibitor potency. Biochemistry. 41: 13915-25. PMID 12437348 DOI: 10.1021/Bi026313J  0.517
2002 Zamora R, Vodovotz Y, Aulak KS, Kim PKM, Kane JM, Alarcon L, Stuehr DJ, Billiar TR. A DNA microarray study of nitric oxide-induced genes in mouse hepatocytes: Implications for hepatic heme oxygenase-1 expression in ischemia/reperfusion Nitric Oxide - Biology and Chemistry. 7: 165-186. PMID 12381414 DOI: 10.1016/S1089-8603(02)00104-0  0.461
2002 Adak S, Sharma M, Meade AL, Stuehr DJ. A conserved flavin-shielding residue regulates NO synthase electron transfer and nicotinamide coenzyme specificity. Proceedings of the National Academy of Sciences of the United States of America. 99: 13516-21. PMID 12359874 DOI: 10.1073/Pnas.192283399  0.494
2002 Wei CC, Wang ZQ, Meade AL, McDonald JF, Stuehr DJ. Why do nitric oxide synthases use tetrahydrobiopterin? Journal of Inorganic Biochemistry. 91: 618-24. PMID 12237227 DOI: 10.1016/S0162-0134(02)00432-4  0.463
2002 Pant K, Bilwes AM, Adak S, Stuehr DJ, Crane BR. Structure of a nitric oxide synthase heme protein from Bacillus subtilis. Biochemistry. 41: 11071-9. PMID 12220171 DOI: 10.1021/Bi0263715  0.575
2002 Dijols S, Boucher JL, Lepoivre M, Lefevre-Groboillot D, Moreau M, Frapart Y, Rekka E, Meade AL, Stuehr DJ, Mansuy D. First non-α-amino acid guanidines acting as efficient NO precursors upon oxidation by NO-synthase II or activated mouse macrophages Biochemistry. 41: 9286-9292. PMID 12135349 DOI: 10.1021/Bi025691L  0.531
2002 Miyagi M, Sakaguchi H, Darrow RM, Yan L, West KA, Aulak KS, Stuehr DJ, Hollyfield JG, Organisciak DT, Crabb JW. Evidence that light modulates protein nitration in rat retina. Molecular & Cellular Proteomics : McP. 1: 293-303. PMID 12096111 DOI: 10.1074/Mcp.M100034-Mcp200  0.371
2002 Panda K, Rosenfeld RJ, Ghosh S, Meade AL, Getzoff ED, Stuehr DJ. Distinct dimer interaction and regulation in nitric-oxide synthase types I, II, and III. The Journal of Biological Chemistry. 277: 31020-30. PMID 12048205 DOI: 10.1074/Jbc.M203749200  0.443
2002 Jeng BH, Meisler DM, Hollyfield JG, Connor JT, Aulak KS, Stuehr DJ. Nitric oxide generated by corneas in corneal storage media. Cornea. 21: 410-4. PMID 11973392 DOI: 10.1097/00003226-200205000-00015  0.428
2002 Chen Y, Panda K, Stuehr DJ. Control of nitric oxide synthase dimer assembly by a heme-NO-dependent mechanism. Biochemistry. 41: 4618-25. PMID 11926824 DOI: 10.1021/Bi011877T  0.544
2002 Adak S, Aulak KS, Stuehr DJ. Direct evidence for nitric oxide production by a nitric-oxide synthase-like protein from Bacillus subtilis. The Journal of Biological Chemistry. 277: 16167-71. PMID 11856757 DOI: 10.1074/Jbc.M201136200  0.543
2002 Renodon-Cornière A, Dijols S, Perollier C, Lefevre-Groboillot D, Boucher JL, Attias R, Sari MA, Stuehr D, Mansuy D. N-aryl N′-hydroxyguanidines, a new class of NO-donors after selective oxidation by nitric oxide synthases: Structure-activity relationship Journal of Medicinal Chemistry. 45: 944-954. PMID 11831907 DOI: 10.1021/Jm011006H  0.491
2002 Wang ZQ, Wei CC, Stuehr DJ. A conserved tryptophan 457 modulates the kinetics and extent of N-hydroxy-L-arginine oxidation by inducible nitric-oxide synthase. The Journal of Biological Chemistry. 277: 12830-7. PMID 11823464 DOI: 10.1074/Jbc.M111967200  0.521
2002 Adak S, Bilwes AM, Panda K, Hosfield D, Aulak KS, McDonald JF, Tainer JA, Getzoff ED, Crane BR, Stuehr DJ. Cloning, expression, and characterization of a nitric oxide synthase protein from Deinococcus radiodurans. Proceedings of the National Academy of Sciences of the United States of America. 99: 107-12. PMID 11756668 DOI: 10.1073/Pnas.012470099  0.556
2002 Blasko E, Glaser CB, Devlin JJ, Xia W, Feldman RI, Polokoff MA, Phillips GB, Whitlow M, Auld DS, McMillan K, Ghosh S, Stuehr DJ, Parkinson JF. Mechanistic studies with potent and selective inducible nitric-oxide synthase dimerization inhibitors. The Journal of Biological Chemistry. 277: 295-302. PMID 11689556 DOI: 10.1074/Jbc.M105691200  0.499
2002 Garcin ED, Lloyd SJ, Arvai AS, Tsuruta H, Meade A, Stuehr DJ, Tainer JA, Getzoff ED. Crystal structures of oxygenase and reductase modules of nitric oxide synthase: enzyme mechanism and regulation of electron transfer revealed Acta Crystallographica Section a Foundations of Crystallography. 58: c292-c292. DOI: 10.1107/S0108767302096666  0.417
2001 Santolini J, Meade AL, Stuehr DJ. Differences in three kinetic parameters underpin the unique catalytic profiles of nitric-oxide synthases I, II, and III. The Journal of Biological Chemistry. 276: 48887-98. PMID 11684690 DOI: 10.1074/Jbc.M108666200  0.509
2001 Aoyagi M, Arvai AS, Ghosh S, Stuehr DJ, Tainer JA, Getzoff ED. Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457. Biochemistry. 40: 12826-32. PMID 11669619 DOI: 10.1021/Bi011183K  0.465
2001 Wang ZQ, Wei CC, Ghosh S, Meade AL, Hemann C, Hille R, Stuehr DJ. A conserved tryptophan in nitric oxide synthase regulates heme-dioxy reduction by tetrahydrobiopterin. Biochemistry. 40: 12819-25. PMID 11669618 DOI: 10.1021/Bi011182S  0.459
2001 Aulak KS, Miyagi M, Yan L, West KA, Massillon D, Crabb JW, Stuehr DJ. Proteomic method identifies proteins nitrated in vivo during inflammatory challenge Proceedings of the National Academy of Sciences of the United States of America. 98: 12056-12061. PMID 11593016 DOI: 10.1073/Pnas.221269198  0.434
2001 Dijols S, Perollier C, Lefevre-Groboillot D, Pethe S, Attias R, Boucher JL, Stuehr DJ, Mansuy D. Oxidation of Nω-hydroxyarginine analogues by NO-synthase: The simple, non amino acid N-butyl N′-hydroxyguanidine is almost as efficient an NO precursor as Nω-hydroxyarginine Journal of Medicinal Chemistry. 44: 3199-3202. PMID 11563918 DOI: 10.1021/jm0155446  0.349
2001 Couture M, Adak S, Stuehr DJ, Rousseau DL. Regulation of the properties of the heme-NO complexes in nitric-oxide synthase by hydrogen bonding to the proximal cysteine. The Journal of Biological Chemistry. 276: 38280-8. PMID 11479310 DOI: 10.1074/Jbc.M105341200  0.388
2001 Zamora R, Vodovotz Y, Alarcon L, Betten B, Loughran PA, Aulak KS, Stuehr DJ, Gibson KF, Billiar TR. Nitric oxide from the inducible nitric oxide synthase (iNOS) increases the expression of cytochrome P450 2E1 in iNOS-null hepatocytes in the absence of inflammatory stimuli Archives of Biochemistry and Biophysics. 390: 287-294. PMID 11396931 DOI: 10.1006/Abbi.2001.2391  0.454
2001 Abu-Soud HM, Ichimori K, Nakazawa H, Stuehr DJ. Regulation of inducible nitric oxide synthase by self-generated NO. Biochemistry. 40: 6876-81. PMID 11389602 DOI: 10.1021/Bi010066M  0.526
2001 Panda K, Ghosh S, Stuehr DJ. Calmodulin activates intersubunit electron transfer in the neuronal nitric-oxide synthase dimer. The Journal of Biological Chemistry. 276: 23349-56. PMID 11325964 DOI: 10.1074/Jbc.M100687200  0.482
2001 Adak S, Aulak KS, Stuehr DJ. Chimeras of nitric-oxide synthase types I and III establish fundamental correlates between heme reduction, heme-NO complex formation, and catalytic activity. The Journal of Biological Chemistry. 276: 23246-52. PMID 11313363 DOI: 10.1074/Jbc.M102509200  0.547
2001 Adak S, Stuehr DJ. A proximal tryptophan in NO synthase controls activity by a novel mechanism. Journal of Inorganic Biochemistry. 83: 301-8. PMID 11293550 DOI: 10.1016/S0162-0134(00)00176-8  0.528
2001 Stuehr D, Pou S, Rosen GM. Oxygen reduction by nitric-oxide synthases. The Journal of Biological Chemistry. 276: 14533-6. PMID 11279231 DOI: 10.1074/JBC.R100011200  0.409
2001 Moali C, Boucher JL, Renodon-Corniere A, Stuehr DJ, Mansuy D. Oxidations of N(omega)-hydroxyarginine analogues and various N-hydroxyguanidines by NO synthase II: key role of tetrahydrobiopterin in the reaction mechanism and substrate selectivity. Chemical Research in Toxicology. 14: 202-10. PMID 11258969 DOI: 10.1021/Tx0001068  0.502
2001 Santolini J, Adak S, Curran CM, Stuehr DJ. A kinetic simulation model that describes catalysis and regulation in nitric-oxide synthase. The Journal of Biological Chemistry. 276: 1233-43. PMID 11038356 DOI: 10.1074/Jbc.M006858200  0.469
2001 Adak S, Santolini J, Tikunova S, Wang Q, Johnson JD, Stuehr DJ. Neuronal nitric-oxide synthase mutant (Ser-1412 --> Asp) demonstrates surprising connections between heme reduction, NO complex formation, and catalysis. The Journal of Biological Chemistry. 276: 1244-52. PMID 11038355 DOI: 10.1074/Jbc.M006857200  0.413
2001 Wei CC, Wang ZQ, Wang Q, Meade AL, Hemann C, Hille R, Stuehr DJ. Rapid kinetic studies link tetrahydrobiopterin radical formation to heme-dioxy reduction and arginine hydroxylation in inducible nitric-oxide synthase Journal of Biological Chemistry. 276: 315-319. PMID 11020389 DOI: 10.1074/Jbc.M008441200  0.546
2000 Jung C, Stuehr DJ, Ghosh DK. FT-Infrared spectroscopic studies of the iron ligand CO stretch mode of iNOS oxygenase domain: effect of arginine and tetrahydrobiopterin. Biochemistry. 39: 10163-71. PMID 10956005 DOI: 10.1021/Bi0003792  0.42
2000 Adak S, Wang Q, Stuehr DJ. Arginine conversion to nitroxide by tetrahydrobiopterin-free neuronal nitric-oxide synthase. Implications for mechanism. The Journal of Biological Chemistry. 275: 33554-61. PMID 10945985 DOI: 10.1074/Jbc.M004337200  0.571
2000 Moali C, Brollo M, Custot J, Sari MA, Boucher JL, Stuehr DJ, Mansuy D. Recognition of alpha-amino acids bearing various C=NOH functions by nitric oxide synthase and arginase involves very different structural determinants. Biochemistry. 39: 8208-18. PMID 10889028 DOI: 10.1021/Bi992992V  0.451
2000 Crane BR, Arvai AS, Ghosh S, Getzoff ED, Stuehr DJ, Tainer JA. Structures of the N(omega)-hydroxy-L-arginine complex of inducible nitric oxide synthase oxygenase dimer with active and inactive pterins. Biochemistry. 39: 4608-21. PMID 10769116 DOI: 10.1021/Bi992409A  0.523
2000 Abu-Soud HM, Ichimori K, Presta A, Stuehr DJ. Electron transfer, oxygen binding, and nitric oxide feedback inhibition in endothelial nitric-oxide synthase. The Journal of Biological Chemistry. 275: 17349-57. PMID 10749853 DOI: 10.1074/Jbc.M000050200  0.571
2000 Adak S, Wang Q, Stuehr DJ. Molecular basis for hyperactivity in tryptophan 409 mutants of neuronal NO synthase. The Journal of Biological Chemistry. 275: 17434-9. PMID 10747960 DOI: 10.1074/Jbc.M000846200  0.495
2000 Boggs S, Huang L, Stuehr DJ. Formation and reactions of the heme-dioxygen intermediate in the first and second steps of nitric oxide synthesis as studied by stopped-flow spectroscopy under single-turnover conditions. Biochemistry. 39: 2332-9. PMID 10694400 DOI: 10.1021/Bi9920228  0.535
2000 Couture M, Stuehr DJ, Rousseau DL. The ferrous dioxygen complex of the oxygenase domain of neuronal nitric- oxide synthase Journal of Biological Chemistry. 275: 3201-3205. PMID 10652305 DOI: 10.1074/Jbc.275.5.3201  0.399
1999 Crane BR, Rosenfeld RJ, Arvai AS, Ghosh DK, Ghosh S, Tainer JA, Stuehr DJ, Getzoff ED. N-terminal domain swapping and metal ion binding in nitric oxide synthase dimerization. The Embo Journal. 18: 6271-81. PMID 10562539 DOI: 10.1093/Emboj/18.22.6271  0.482
1999 Ghosh DK, Crane BR, Ghosh S, Wolan D, Gachhui R, Crooks C, Presta A, Tainer JA, Getzoff ED, Stuehr DJ. Inducible nitric oxide synthase: role of the N-terminal beta-hairpin hook and pterin-binding segment in dimerization and tetrahydrobiopterin interaction. The Embo Journal. 18: 6260-70. PMID 10562538 DOI: 10.1093/Emboj/18.22.6260  0.482
1999 Abu-Soud HM, Wang J, Rousseau DL, Stuehr DJ. Stopped-flow analysis of substrate binding to neuronal nitric oxide synthase Biochemistry. 38: 12446-12451. PMID 10493814 DOI: 10.1021/Bi990698X  0.478
1999 Adak S, Crooks C, Wang Q, Crane BR, Tainer JA, Getzoff ED, Stuehr DJ. Tryptophan 409 controls the activity of neuronal nitric-oxide synthase by regulating nitric oxide feedback inhibition. The Journal of Biological Chemistry. 274: 26907-11. PMID 10480900 DOI: 10.1074/Jbc.274.38.26907  0.56
1999 Ghosh S, Wolan D, Adak S, Crane BR, Kwon NS, Tainer JA, Getzoff ED, Stuehr DJ. Mutational analysis of the tetrahydrobiopterin-binding site in inducible nitric-oxide synthase. The Journal of Biological Chemistry. 274: 24100-12. PMID 10446182 DOI: 10.1074/Jbc.274.34.24100  0.535
1999 Adak S, Ghosh S, Abu-Soud HM, Stuehr DJ. Role of reductase domain cluster 1 acidic residues in neuronal nitric-oxide synthase. Characterization of the FMN-FREE enzyme. The Journal of Biological Chemistry. 274: 22313-20. PMID 10428800 DOI: 10.1074/Jbc.274.32.22313  0.502
1999 Ichimori K, Stuehr DJ, Atkinson RN, King SB. Synthesis and evaluation of new sulfur-containing L-arginine-derived inhibitors of nitric oxide synthase Journal of Medicinal Chemistry. 42: 1842-1848. PMID 10346937 DOI: 10.1021/jm980232x  0.391
1999 Renodon-Cornière A, Boucher JL, Dijols S, Stuehr DJ, Mansuy D. Efficient formation of nitric oxide from selective oxidation of N-aryl N'-hydroxyguanidines by inducible nitric oxide synthase. Biochemistry. 38: 4663-8. PMID 10200153 DOI: 10.1021/Bi982930P  0.534
1999 Huang L, Abu-Soud HM, Hille R, Stuehr DJ. Nitric oxide-generated P420 nitric oxide synthase: Characterization and roles for tetrahydrobiopterin and substrate in protecting against or reversing the P420 conversion Biochemistry. 38: 1912-1920. PMID 10026272 DOI: 10.1021/Bi981954T  0.515
1999 Sennequier N, Wolan D, Stuehr DJ. Antifungal imidazoles block assembly of inducible NO synthase into an active dimer Journal of Biological Chemistry. 274: 930-938. PMID 9873034 DOI: 10.1074/Jbc.274.2.930  0.533
1999 Witteveen CF, Giovanelli J, Yim MB, Gachhui R, Stuehr DJ, Kaufman S. Reactivity of the Flavin Semiquinone of Nitric Oxide Synthase in the Oxygenation of Arginine to NG-Hydroxyarginine, the First Step of Nitric Oxide Synthesis Biochemical and Biophysical Research Communications. 256: 447-448. DOI: 10.1006/Bbrc.1999.0338  0.514
1998 Schrammel A, Gorren AC, Stuehr DJ, Schmidt K, Mayer B. Isoform-specific effects of salts on nitric oxide synthase activity. Biochimica Et Biophysica Acta. 1387: 257-63. PMID 9748616 DOI: 10.1016/S0167-4838(98)00138-1  0.546
1998 Witteveen CF, Giovanelli J, Yim MB, Gachhui R, Stuehr DJ, Kaufman S. Reactivity of the flavin semiquinone of nitric oxide synthase in the oxygenation of arginine to NG-hydroxyarginine, the first step of nitric oxide synthesis. Biochemical and Biophysical Research Communications. 250: 36-42. PMID 9735327 DOI: 10.1006/Bbrc.1998.8807  0.514
1998 Ghosh S, Gachhui R, Crooks C, Wu C, Lisanti MP, Stuehr DJ. Interaction between caveolin-1 and the reductase domain of endothelial nitric-oxide synthase. Consequences for catalysis. The Journal of Biological Chemistry. 273: 22267-71. PMID 9712842 DOI: 10.1074/Jbc.273.35.22267  0.442
1998 Presta A, Liu J, Sessa WC, Stuehr DJ. Substrate binding and calmodulin binding to endothelial nitric oxide synthase coregulate its enzymatic activity. Nitric Oxide : Biology and Chemistry. 1: 74-87. PMID 9701047 DOI: 10.1006/Niox.1996.0110  0.542
1998 Moali C, Boucher JL, Sari MA, Stuehr DJ, Mansuy D. Substrate specificity of NO synthases: detailed comparison of L-arginine, homo-L-arginine, their N omega-hydroxy derivatives, and N omega-hydroxynor-L-arginine. Biochemistry. 37: 10453-60. PMID 9671515 DOI: 10.1021/Bi980742T  0.508
1998 Siddhanta U, Presta A, Fan B, Wolan D, Rousseau DL, Stuehr DJ. Domain swapping in inducible nitric-oxide synthase: Electron transfer occurs between flavin and heme groups located on adjacent subunits in the dimer Journal of Biological Chemistry. 273: 18950-18958. PMID 9668073 DOI: 10.1074/Jbc.273.30.18950  0.399
1998 Renodon A, Boucher JL, Wu C, Gachhui R, Sari MA, Mansuy D, Stuehr D. Formation of nitric oxide synthase-iron(II) nitrosoalkane complexes: Severe restriction of access to the iron(II) site in the presence of tetrahydrobiopterin Biochemistry. 37: 6367-6374. PMID 9572852 DOI: 10.1021/Bi972297S  0.468
1998 Abu-Soud HM, Wu C, Ghosh DK, Stuehr DJ. Stopped-flow analysis of CO and NO binding to inducible nitric oxide synthase. Biochemistry. 37: 3777-86. PMID 9521697 DOI: 10.1021/Bi972398Q  0.508
1998 Crane BR, Arvai AS, Ghosh DK, Wu C, Getzoff ED, Stuehr DJ, Tainer JA. Structure of nitric oxide synthase oxygenase dimer with pterin and substrate. Science (New York, N.Y.). 279: 2121-6. PMID 9516116 DOI: 10.1126/Science.279.5359.2121  0.564
1998 Gachhui R, Abu-Soud HM, Ghosha DK, Presta A, Blazing MA, Mayer B, George SE, Stuehr DJ. Neuronal nitric-oxide synthase interaction with calmodulin-troponin C chimeras. The Journal of Biological Chemistry. 273: 5451-4. PMID 9488666 DOI: 10.1074/jbc.273.10.5451  0.426
1998 Dweik RA, Laskowski D, Abu-Soud HM, Kaneko FT, Hutte R, Stuehr DJ, Erzurum SC. Nitric oxide synthesis in the lung. Regulation by oxygen through a kinetic mechanism Journal of Clinical Investigation. 101: 660-666. PMID 9449700 DOI: 10.1172/Jci1378  0.441
1998 Presta A, Siddhanta U, Wu C, Sennequier N, Huang L, Abu-Soud HM, Erzurum S, Stuehr DJ. Comparative functioning of dihydro- and tetrahydropterins in supporting electron transfer, catalysis, and subunit dimerization in inducible nitric oxide synthase. Biochemistry. 37: 298-310. PMID 9425051 DOI: 10.1021/Bi971944C  0.553
1998 Presta A, Weber-Main AM, Stankovich MT, Stuehr DJ. Comparative effects of substrates and pterin cofactor on the heme midpoint potential in inducible and neuronal nitric oxide synthases Journal of the American Chemical Society. 120: 9460-9465. DOI: 10.1021/Ja9740374  0.557
1997 Fan B, Wang J, Stuehr DJ, Rousseau DL. NO synthase isozymes have distinct substrate binding sites Biochemistry. 36: 12660-12665. PMID 9376373 DOI: 10.1021/Bi9715369  0.493
1997 Crane BR, Arvai AS, Gachhui R, Wu C, Ghosh DK, Getzoff ED, Stuehr DJ, Tainer JA. The structure of nitric oxide synthase oxygenase domain and inhibitor complexes. Science (New York, N.Y.). 278: 425-31. PMID 9334294 DOI: 10.1126/Science.278.5337.425  0.481
1997 Abu-Soud HM, Presta A, Mayer B, Stuehr DJ. Analysis of neuronal NO synthase under single-turnover conditions: conversion of Nomega-hydroxyarginine to nitric oxide and citrulline. Biochemistry. 36: 10811-6. PMID 9312270 DOI: 10.1021/Bi971414G  0.531
1997 Fukumoto S, Hirai K, Tanihata T, Ohmori Y, Stuehr DJ, Hamilton TA. Excretory/secretory products from plerocercoids of Spirometra erinacei reduce iNOS and chemokine mRNA levels in peritoneal macrophages stimulated with cytokines and/or LPS Parasite Immunology. 19: 325-332. PMID 9278945 DOI: 10.1046/J.1365-3024.1997.D01-215.X  0.405
1997 Ghosh DK, Wu C, Pitters E, Moloney M, Werner ER, Mayer B, Stuehr DJ. Characterization of the inducible nitric oxide synthase oxygenase domain identifies a 49 amino acid segment required for subunit dimerization and tetrahydrobiopterin interaction. Biochemistry. 36: 10609-19. PMID 9271491 DOI: 10.1021/Bi9702290  0.529
1997 Abu-Soud HM, Gachhui R, Raushel FM, Stuehr DJ. The ferrous-dioxy complex of neuronal nitric oxide synthase: Divergent effects of L-arginine and tetrahydrobiopterin on its stability Journal of Biological Chemistry. 272: 17349-17353. PMID 9211873 DOI: 10.1074/Jbc.272.28.17349  0.448
1997 Mayer B, Wu C, Gorren AC, Pfeiffer S, Schmidt K, Clark P, Stuehr DJ, Werner ER. Tetrahydrobiopterin binding to macrophage inducible nitric oxide synthase: heme spin shift and dimer stabilization by the potent pterin antagonist 4-amino-tetrahydrobiopterin. Biochemistry. 36: 8422-7. PMID 9204890 DOI: 10.1021/Bi970144Z  0.534
1997 Gachhui R, Ghosh DK, Wu C, Parkinson J, Crane BR, Stuehr DJ. Mutagenesis of acidic residues in the oxygenase domain of inducible nitric-oxide synthase identifies a glutamate involved in arginine binding. Biochemistry. 36: 5097-103. PMID 9136868 DOI: 10.1021/Bi970331X  0.495
1997 Stuehr DJ. Structure-function aspects in the nitric oxide synthases. Annual Review of Pharmacology and Toxicology. 37: 339-59. PMID 9131257 DOI: 10.1146/Annurev.Pharmtox.37.1.339  0.554
1997 Wang J, Stuehr DJ, Rousseau DL. Interactions between substrate analogues and heme ligands in nitric oxide synthase Biochemistry. 36: 4595-4606. PMID 9109669 DOI: 10.1021/Bi962309U  0.511
1997 Stuehr DJ. Purification and properties of nitric oxide synthases. Methods in Enzymology. 268: 324-33. PMID 8782598 DOI: 10.1016/S0076-6879(96)68034-3  0.507
1996 Abu-Soud HM, Rousseau DL, Stuehr DJ. Nitric oxide binding to the heme of neuronal nitric-oxide synthase links its activity to changes in oxygen tension Journal of Biological Chemistry. 271: 32515-32518. PMID 8955074 DOI: 10.1074/Jbc.271.51.32515  0.475
1996 Gachhui R, Presta A, Bentley DF, Abu-Soud HM, McArthur R, Brudvig G, Ghosh DK, Stuehr DJ. Characterization of the reductase domain of rat neuronal nitric oxide synthase generated in the methylotrophic yeast Pichia pastoris. Calmodulin response is complete within the reductase domain itself. The Journal of Biological Chemistry. 271: 20594-602. PMID 8702805 DOI: 10.1074/Jbc.271.34.20594  0.509
1996 Wu C, Zhang J, Abu-Soud H, Ghosh DK, Stuehr DJ. High-level expression of mouse inducible nitric oxide synthase in Escherichia coli requires coexpression with calmodulin. Biochemical and Biophysical Research Communications. 222: 439-44. PMID 8670224 DOI: 10.1006/Bbrc.1996.0763  0.49
1996 Sennequier N, Stuehr DJ. Analysis of substrate-induced electronic, catalytic, and structural changes in inducible NO synthase. Biochemistry. 35: 5883-92. PMID 8639550 DOI: 10.1021/Bi952844E  0.558
1996 Ghosh DK, Abu-Soud HM, Stuehr DJ. Domains of macrophage N(O) synthase have divergent roles in forming and stabilizing the active dimeric enzyme. Biochemistry. 35: 1444-9. PMID 8634274 DOI: 10.1021/Bi9521295  0.483
1996 Siddhanta U, Wu C, Abu-Soud HM, Zhang J, Ghosh DK, Stuehr DJ. Heme iron reduction and catalysis by a nitric oxide synthase heterodimer containing one reductase and two oxygenase domains. The Journal of Biological Chemistry. 271: 7309-12. PMID 8631749 DOI: 10.1074/Jbc.271.13.7309  0.529
1996 Albakri QA, Stuehr DJ. Intracellular assembly of inducible NO synthase is limited by nitric oxide-mediated changes in heme insertion and availability. The Journal of Biological Chemistry. 271: 5414-21. PMID 8621396 DOI: 10.1074/Jbc.271.10.5414  0.536
1996 Galli C, MacArthur R, Abu-Soud HM, Clark P, Stuehr DJ, Brudvig GW. EPR Spectroscopic Characterization of Neuronal NO Synthase Biochemistry. 35: 7298-7298. DOI: 10.1021/Bi965003W  0.352
1996 Feldman PL, Chi S, Sennequier N, Stuehr DJ. Synthesis of the L-arginine congener L-Indospicine and evaluation of its interaction with nitric oxide synthase Bioorganic & Medicinal Chemistry Letters. 6: 111-114. DOI: 10.1016/0960-894X(95)00569-F  0.491
1995 Stuehr DJ, Abu-Soud HM, Rousseau DL, Feldman PL, Wang J. Control of electron transfer in neuronal nitric oxide synthase by calmodulin, substrate, substrate analogs, and nitric oxide. Advances in Pharmacology (San Diego, Calif.). 34: 207-13. PMID 8562435 DOI: 10.1016/S1054-3589(08)61087-X  0.551
1995 Tzeng E, Billiar TR, Robbins PD, Loftus M, Stuehr DJ. Expression of human inducible nitric oxide synthase in a tetrahydrobiopterin (H4B)-deficient cell line: H4B promotes assembly of enzyme subunits into an active dimer. Proceedings of the National Academy of Sciences of the United States of America. 92: 11771-5. PMID 8524846 DOI: 10.1073/Pnas.92.25.11771  0.526
1995 Abu-Soud HM, Wang J, Rousseau DL, Fukuto JM, Ignarro LJ, Stuehr DJ. Neuronal nitric oxide synthase self-inactivates by forming a ferrous-nitrosyl complex during aerobic catalysis Journal of Biological Chemistry. 270: 22997-23006. PMID 7559438 DOI: 10.1074/Jbc.270.39.22997  0.648
1995 Ghosh DK, Abu-Soud HM, Stuehr DJ. Reconstitution of the second step in NO synthesis using the isolated oxygenase and reductase domains of macrophage NO synthase. Biochemistry. 34: 11316-20. PMID 7547858 DOI: 10.1021/Bi00036A003  0.515
1995 Abu-Soud HM, Loftus M, Stuehr DJ. Subunit dissociation and unfolding of macrophage NO synthase: relationship between enzyme structure, prosthetic group binding, and catalytic function. Biochemistry. 34: 11167-75. PMID 7545434 DOI: 10.1021/Bi00035A023  0.499
1995 Sono M, Stuehr DJ, Ikeda-Saito M, Dawson JH. Identification of nitric oxide synthase as a thiolate-ligated heme protein using magnetic circular dichroism spectroscopy. Comparison with cytochrome P-450-CAM and chloroperoxidase. The Journal of Biological Chemistry. 270: 19943-8. PMID 7544348 DOI: 10.1074/Jbc.270.34.19943  0.499
1995 Guo FH, De Raeve HR, Rice TW, Stuehr DJ, Thunnissen FBJM, Erzurum SC. Continuous nitric oxide synthesis by inducible nitric oxide synthase in normal human airway epithelium in vivo Proceedings of the National Academy of Sciences of the United States of America. 92: 7809-7813. PMID 7544004 DOI: 10.1073/Pnas.92.17.7809  0.452
1995 Griffith OW, Stuehr DJ. Nitric oxide synthases: Properties and catalytic mechanism Annual Review of Physiology. 57: 707-736. PMID 7539994 DOI: 10.1146/Annurev.Ph.57.030195.003423  0.508
1995 Wang J, Stuehr DJ, Rousseau DL. Tetrahydrobiopterin-deficient nitric oxide synthase has a modified heme environment and forms a cytochrome P-420 analogue Biochemistry. 34: 7080-7087. PMID 7539291 DOI: 10.1021/Bi00021A020  0.484
1994 Wang J, Rousseau DL, Abu-Soud HM, Stuehr DJ. Heme coordination of NO in NO synthase Proceedings of the National Academy of Sciences of the United States of America. 91: 10512-10516. PMID 7524095 DOI: 10.1073/Pnas.91.22.10512  0.516
1993 Fukuto JM, Stuehr DJ, Feldman PL, Bova MP, Wong P. Peracid oxidation of an N-hydroxyguanidine compound: a chemical model for the oxidation of N omega-hydroxyl-L-arginine by nitric oxide synthase. Journal of Medicinal Chemistry. 36: 2666-70. PMID 7692046 DOI: 10.1021/Jm00070A010  0.523
1993 Feldman PL, Griffith OW, Hong H, Stuehr DJ. Irreversible inactivation of macrophage and brain nitric oxide synthase by L-NG-methylarginine requires NADPH-dependent hydroxylation. Journal of Medicinal Chemistry. 36: 491-6. PMID 7682617 DOI: 10.1021/Jm00056A009  0.528
1993 Abu-Soud HM, Stuehr DJ. Nitric oxide synthases reveal a role for calmodulin in controlling electron transfer. Proceedings of the National Academy of Sciences of the United States of America. 90: 10769-72. PMID 7504282 DOI: 10.1073/Pnas.90.22.10769  0.527
1993 Wang J, Stuehr DJ, Ikeda-Saito M, Rousseau DL. Nitric oxide synthase: Properties of the heme catalytic site from Raman scattering. Journal of Inorganic Biochemistry. 51: 146. DOI: 10.1016/0162-0134(93)85182-8  0.471
1993 Stuehr DJ, Sapse A, Sapse DS. An ab initio study of an oxidative mechanism that forms nitric oxide from theN-hydroxyguanidinium ion Structural Chemistry. 4: 143-147. DOI: 10.1007/Bf00679340  0.533
1993 Feldman PL, Griffith OW, Stuehr DJ. The surprising life of nitric oxide Chemical and Engineering News. 71: 26-38.  0.379
1992 Stuehr DJ, Griffith OW. Mammalian nitric oxide synthases. Advances in Enzymology and Related Areas of Molecular Biology. 65: 287-346. PMID 1373932 DOI: 10.1016/S0005-2728(99)00016-X  0.537
1991 Stadler J, Billiar TR, Curran RD, Stuehr DJ, Ochoa JB, Simmons RL. Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes. The American Journal of Physiology. 260: C910-6. PMID 1903597 DOI: 10.1152/AJPCELL.1991.260.5.C910  0.331
1991 Kwon NS, Stuehr DJ, Nathan CF. Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide Journal of Experimental Medicine. 174: 761-767. PMID 1717630 DOI: 10.1084/Jem.174.4.761  0.487
1991 Stuehr DJ, Cho HJ, Kwon NS, Weise MF, Nathan CF. Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein. Proceedings of the National Academy of Sciences of the United States of America. 88: 7773-7. PMID 1715579 DOI: 10.1073/Pnas.88.17.7773  0.54
1991 Curran RD, Ferrari FK, Kispert PH, Stadler J, Stuehr DJ, Simmons RL, Billiar TR. Nitric oxide and nitric oxide-generating compounds inhibit hepatocyte protein synthesis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 5: 2085-92. PMID 1707021 DOI: 10.1096/fasebj.5.7.1707021  0.407
1991 Stuehr DJ, Fasehun OA, Kwon NS, Gross SS, Gonzalez JA, Levi R, Nathan CF. Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 5: 98-103. PMID 1703974 DOI: 10.1096/Fasebj.5.1.1703974  0.491
1990 Gross SS, Stuehr DJ, Aisaka K, Jaffe EA, Levi R, Griffith OW. Macrophage and endothelial cell nitric oxide synthesis: cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine. Biochemical and Biophysical Research Communications. 170: 96-103. PMID 2372300 DOI: 10.1016/0006-291X(90)91245-N  0.487
1990 Billiar TR, Curran RD, Stuehr DJ, Stadler J, Simmons RL, Murray SA. Inducible cytosolic enzyme activity for the production of nitrogen oxides from L-arginine in hepatocytes. Biochemical and Biophysical Research Communications. 168: 1034-40. PMID 2346476 DOI: 10.1016/0006-291X(90)91133-D  0.525
1990 Billiar TR, Curran RD, Harbrecht BG, Stuehr DJ, Demetris AJ, Simmons RL. Modulation of nitrogen oxide synthesis in vivo: NG-monomethyl-L-arginine inhibits endotoxin-induced nitrate/nitrate biosynthesis while promoting hepatic damage. Journal of Leukocyte Biology. 48: 565-9. PMID 2230601 DOI: 10.1002/Jlb.48.6.565  0.458
1990 Curran RD, Billiar TR, Stuehr DJ, Ochoa JB, Harbrecht BG, Flint SG, Simmons RL. Multiple cytokines are required to induce hepatocyte nitric oxide production and inhibit total protein synthesis. Annals of Surgery. 212: 462-9; discussion 47. PMID 2121110 DOI: 10.1097/00000658-199010000-00009  0.516
1990 Stuehr DJ, Kwon NS, Nathan CF. FAD and GSH participate in macrophage synthesis of nitric oxide Biochemical and Biophysical Research Communications. 168: 558-565. PMID 1692211 DOI: 10.1016/0006-291X(90)92357-6  0.542
1990 Nathan CF, Stuehr DJ. Does endothelium-derived nitric oxide have a rolein cytokine-induced hypotension? Journal of the National Cancer Institute. 82: 726-728. PMID 1691302 DOI: 10.1093/Jnci/82.9.726  0.5
1989 Stuehr DJ, Gross SS, Sakuma I, Levi R, Nathan CF. Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide. The Journal of Experimental Medicine. 169: 1011-20. PMID 2784476 DOI: 10.1084/Jem.169.3.1011  0.522
1989 Stuehr DJ, Kwon NS, Gross SS, Thiel BA, Levi R, Nathan CF. Synthesis of nitrogen oxides from L-arginine by macrophage cytosol: requirement for inducible and constitutive components. Biochemical and Biophysical Research Communications. 161: 420-6. PMID 2735902 DOI: 10.1016/0006-291X(89)92615-6  0.542
1989 Curran RD, Billiar TR, Stuehr DJ, Hofmann K, Simmons RL. Hepatocytes produce nitrogen oxides from L-arginine in response to inflammatory products of Kupffer cells. The Journal of Experimental Medicine. 170: 1769-74. PMID 2509627 DOI: 10.1084/JEM.170.5.1769  0.405
1989 Stuehr DJ, Nathan CF. Nitric oxide: A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells Journal of Experimental Medicine. 169: 1543-1555. PMID 2497225 DOI: 10.1084/Jem.169.5.1543  0.503
1989 Swisher RG, Stuehr DJ, Knox J, Fox BM, Blinn EL. The Reactions of Silver(I) With Tetraaza Macrocyclic Ligands Journal of Coordination Chemistry. 20: 101-107. DOI: 10.1080/00958978909408854  0.216
1988 Sakuma I, Stuehr DJ, Gross SS, Nathan C, Levi R. Identification of arginine as a precursor of endothelium-derived relaxing factor Proceedings of the National Academy of Sciences of the United States of America. 85: 8664-8667. PMID 3263652 DOI: 10.1073/Pnas.85.22.8664  0.439
1987 Iyengar R, Stuehr DJ, Marletta MA. Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst. Proceedings of the National Academy of Sciences of the United States of America. 84: 6369-73. PMID 2819872 DOI: 10.1073/Pnas.84.18.6369  0.601
1987 Miwa M, Stuehr DJ, Marletta MA, Wishnok JS, Tannenbaum SR. Nitrosation of amines by stimulated macrophages. Carcinogenesis. 8: 955-8. PMID 2439225 DOI: 10.1093/Carcin/8.7.955  0.594
1985 Stuehr DJ, Marletta MA. Mammalian nitrate biosynthesis: Mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide Proceedings of the National Academy of Sciences of the United States of America. 82: 7738-7742. PMID 3906650 DOI: 10.1073/Pnas.82.22.7738  0.55
1985 Stuehr DJ, Marletta MA. Superoxide-promoted oxidation reactions of aniline and N-methylaniline in dimethyl sulfoxide The Journal of Organic Chemistry. 50: 694-696. DOI: 10.1021/JO00205A028  0.368
1985 Stuehr DJ, Marletta MA. Superoxide-promoted oxidation reactions of aniline and N-methylaniline in dimethyl sulfoxide Journal of Organic Chemistry. 50: 694-696. DOI: 10.1002/Chin.198531131  0.616
1980 Swisher RG, Dayhuff JP, Stuehr DJ, Blinn EL. Effect of altering the ring sequence in nickel(II) complexes containing a 14-membered macrocyclic ligand Inorganic Chemistry. 19: 1336-1340. DOI: 10.1021/ic50207a047  0.242
1980 SWISHER RG, DAYHUFF JP, STUEHR DJ, BLINN EL. ChemInform Abstract: EFFECT OF ALTERING THE RING SEQUENCE IN NICKEL(II) COMPLEXES CONTAINING A 14-MEMBERED MACROCYCLIC LIGAND Chemischer Informationsdienst. 11. DOI: 10.1002/chin.198032295  0.243
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