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James John Crawford - Publications

Affiliations: 
Genentech, Inc., San Francisco, CA, United States 
Area:
Medicinal Chemistry; Organic Chemistry; Drug Discovery
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40 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Anderson M, Carton T, Salvini C, Crawford J, Pairaudeau G, Waring MJ. Micelle-Promoted Reductive Amination of DNA-Conjugated Amines for DNA-Encoded Library Synthesis. Chemistry (Weinheim An Der Bergstrasse, Germany). e202400239. PMID 38251309 DOI: 10.1002/chem.202400239  0.541
2023 Salvini CLA, Darlot B, Davison J, Martin MP, Tudhope SJ, Turberville S, Kawamura A, Noble MEM, Wedge SR, Crawford JJ, Waring MJ. Fragment expansion with NUDELs - poised DNA-encoded libraries. Chemical Science. 14: 8288-8294. PMID 37564419 DOI: 10.1039/d3sc01171b  0.56
2021 Hunter JH, Anderson MJ, Castan IFSF, Graham JS, Salvini CLA, Stanway-Gordon HA, Crawford JJ, Madin A, Pairaudeau G, Waring MJ. Highly efficient on-DNA amide couplings promoted by micelle forming surfactants for the synthesis of DNA encoded libraries. Chemical Science. 12: 9475-9484. PMID 34349922 DOI: 10.1039/d1sc03007h  0.632
2020 Crawford JJ, Lee W, Johnson AR, Delatorre KJ, Chen J, Eigenbrot C, Heidmann J, Kakiuchi-Kiyota S, Katewa A, Kiefer JR, Liu L, Lubach JW, Misner D, Purkey H, Reif K, et al. Stereochemical Differences in Fluorocyclopropyl Amides Enable Tuning of Btk Inhibition and Off-Target Activity. Acs Medicinal Chemistry Letters. 11: 1588-1597. PMID 32832028 DOI: 10.1021/Acsmedchemlett.0C00249  0.324
2020 Zhang C, Crawford JJ, Landry ML, Chen H, Kenny JR, Khojasteh SC, Lee W, Ma S, Young WB. Strategies to Mitigate the Bioactivation of Aryl Amines. Chemical Research in Toxicology. PMID 32508087 DOI: 10.1021/Acs.Chemrestox.0C00138  0.382
2020 Landry ML, Crawford JJ. Log Contributions of Substituents Commonly Used in Medicinal Chemistry. Acs Medicinal Chemistry Letters. 11: 72-76. PMID 31938466 DOI: 10.1021/Acsmedchemlett.9B00489  0.302
2020 Crawford JJ, Liao D, Kolesnikov A, Lee W, Landry ML. Synthesis of an Azabicyclo[3.1.0]hexanone-Containing Inhibitor of NF-κΒ Inducing Kinase via Catalytic C–H Activation Synthesis. DOI: 10.1055/S-0040-1707279  0.417
2019 Bronner SM, Merrick KA, Murray J, Salphati L, Moffat JG, Pang J, Sneeringer CJ, Dompe N, Cyr P, Purkey H, Boenig GL, Li J, Kolesnikov A, Larouche-Gauthier R, Lai KW, ... ... Crawford JJ, et al. Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma. Bioorganic & Medicinal Chemistry Letters. PMID 31307887 DOI: 10.1016/J.Bmcl.2019.06.021  0.316
2018 Crawford JJ, Bronner SM, Zbieg JR. Hippo pathway inhibition by blocking the YAP/TAZ-TEAD interface: a patent review. Expert Opinion On Therapeutic Patents. PMID 30482112 DOI: 10.1080/13543776.2018.1549226  0.32
2018 Blaquiere N, Castanedo G, Burch J, Berezhkovskiy L, Brightbill H, Brown S, Chan C, Chiang PC, Crawford JJ, Dong T, Fan P, Feng J, Ghilardi N, Godemann R, Gogol E, et al. A scaffold-hopping approach to discover potent, selective and efficacious inhibitors of NF-κB inducing kinase. Journal of Medicinal Chemistry. PMID 29940120 DOI: 10.1021/Acs.Jmedchem.8B00678  0.326
2017 Wang X, Barbosa J, Blomgren P, Bremer MC, Chen J, Crawford JJ, Deng W, Dong L, Eigenbrot C, Gallion S, Hau J, Hu H, Johnson AR, Katewa A, Kropf JE, et al. Discovery of Potent and Selective Tricyclic Inhibitors of Bruton's Tyrosine Kinase with Improved Druglike Properties. Acs Medicinal Chemistry Letters. 8: 608-613. PMID 28626519 DOI: 10.1021/Acsmedchemlett.7B00103  0.332
2016 Castanedo G, Liu Y, Crawford JJ, Braun MG. Synthesis of Fused Imidazole-Containing Ring Systems via Dual Oxidative Amination of C(sp3)-H bonds. The Journal of Organic Chemistry. PMID 27529722 DOI: 10.1021/Acs.Joc.6B01517  0.404
2016 Lee W, Crawford JJ, Aliagas I, Murray LJ, Tay S, Wang W, Heise CE, Hoeflich KP, La H, Mathieu S, Mintzer R, Ramaswamy S, Rouge L, Rudolph J. Synthesis and evaluation of a series of 4-azaindole-containing p21-activated kinase-1 inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 27346791 DOI: 10.1016/J.Bmcl.2016.06.031  0.365
2016 Nicolaou KC, Wang Y, Lu M, Mandal D, Pattanayak MR, Yu R, Shah AA, Chen JS, Zhang H, Crawford JJ, Pasunoori L, Poudel YB, Chowdari NS, Pan C, Nazeer A, et al. Streamlined Total Synthesis of Uncialamycin and Its Application to the Synthesis of Designed Analogues for Biological Investigations. Journal of the American Chemical Society. PMID 27266267 DOI: 10.1021/Jacs.6B04339  0.576
2016 Rudolph J, Murray LJ, Ndubaku CO, O'Brien T, Blackwood EM, Wang W, Aliagas I, Gazzard L, Crawford JJ, Drobnick J, Lee W, Zhao X, Hoeflich KP, Favor DA, Dong P, et al. Chemically diverse Group I p21-activated kinase (PAK) inhibitors impart acute cardiovascular toxicity with a narrow therapeutic window. Journal of Medicinal Chemistry. PMID 27167326 DOI: 10.1021/Acs.Jmedchem.6B00638  0.328
2015 Ndubaku CO, Crawford JJ, Drobnick J, Aliagas I, Campbell D, Dong P, Dornan LM, Duron S, Epler J, Gazzard L, Heise CE, Hoeflich KP, Jakubiak D, La H, Lee W, et al. Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety. Acs Medicinal Chemistry Letters. 6: 1241-6. PMID 26713112 DOI: 10.1021/Acsmedchemlett.5B00398  0.328
2015 Young WB, Barbosa J, Blomgren P, Bremer MC, Crawford JJ, Dambach D, Eigenbrot C, Gallion S, Johnson AR, Kropf JE, Lee SH, Liu L, Lubach JW, Macaluso J, Maciejewski P, et al. Discovery of highly potent and selective Bruton's tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability. Bioorganic & Medicinal Chemistry Letters. PMID 26675441 DOI: 10.1016/J.Bmcl.2015.11.076  0.333
2015 Crawford JJ, Lee W, Aliagas I, Mathieu S, Hoeflich KP, Zhou W, Wang W, Rouge L, Murray L, La H, Liu N, Fan PW, Cheong J, Heise CE, Ramaswamy S, et al. Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors. Journal of Medicinal Chemistry. 58: 5121-36. PMID 26030457 DOI: 10.1021/Acs.Jmedchem.5B00572  0.351
2015 Young WB, Barbosa J, Blomgren P, Bremer MC, Crawford JJ, Dambach D, Gallion S, Hymowitz SG, Kropf JE, Lee SH, Liu L, Lubach JW, Macaluso J, Maciejewski P, Maurer B, et al. Potent and selective Bruton's tyrosine kinase inhibitors: discovery of GDC-0834. Bioorganic & Medicinal Chemistry Letters. 25: 1333-7. PMID 25701252 DOI: 10.1016/J.Bmcl.2015.01.032  0.33
2015 Pasqua AE, Ferrari FD, Crawford JJ, Whittingham WG, Marquez R. Synthesis of (+)-crocacin D and simplified bioactive analogues. Bioorganic & Medicinal Chemistry. 23: 1062-8. PMID 25638500 DOI: 10.1016/J.Bmc.2015.01.008  0.379
2015 Rudolph J, Crawford JJ, Hoeflich KP, Wang W. Inhibitors of p21-activated kinases (PAKs). Journal of Medicinal Chemistry. 58: 111-29. PMID 25415869 DOI: 10.1021/Jm501613Q  0.314
2015 Pham V, Crawford J, Saben S, Ford M, Jones R, Daniels D, Kirkland T, Urh M, Lill J. Abstract LB-B10: Chemical Proteomic Analysis of BTK and PI3K Using Chloroalkane-Derivatized Small Molecule Inhibitors Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-Lb-B10  0.31
2014 Pasqua AE, Ferrari FD, Crawford JJ, Marquez R. Total synthesis of lansiumamides A and B and alatamide Tetrahedron Letters. 55: 6042-6043. DOI: 10.1016/J.Tetlet.2014.09.008  0.353
2014 Wong B, Linghu X, Crawford JJ, Drobnick J, Lee W, Zhang H. A chemoselective Reformatsky-Negishi approach to α-haloaryl esters Tetrahedron. 70: 1508-1515. DOI: 10.1016/J.Tet.2013.12.053  0.342
2013 Rudolph J, Crawford JJ, Hoeflich KP, Chernoff J. p21-activated kinase inhibitors. The Enzymes. 34: 157-80. PMID 25034104 DOI: 10.1016/B978-0-12-420146-0.00007-X  0.315
2012 Crawford JJ, Kenny PW, Bowyer J, Cook CR, Finlayson JE, Heyes C, Highton AJ, Hudson JA, Jestel A, Krapp S, Martin S, Macfaul PA, McDermott BP, McGuire TM, Morley AD, et al. Pharmacokinetic benefits of 3,4-dimethoxy substitution of a phenyl ring and design of isosteres yielding orally available cathepsin K inhibitors. Journal of Medicinal Chemistry. 55: 8827-37. PMID 22984809 DOI: 10.1021/Jm301119S  0.518
2012 Dossetter AG, Bowyer J, Cook CR, Crawford JJ, Finlayson JE, Heron NM, Heyes C, Highton AJ, Hudson JA, Jestel A, Krapp S, MacFaul PA, McGuire TM, Morley AD, Morris JJ, et al. Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibition. Bioorganic & Medicinal Chemistry Letters. 22: 5563-8. PMID 22858142 DOI: 10.1016/J.Bmcl.2012.07.012  0.495
2012 Pasqua AE, Ferrari FD, Hamman C, Liu Y, Crawford JJ, Marquez R. Step-economic synthesis of (+)-crocacin C: a concise crotylboronation/[3,3]-sigmatropic rearrangement approach. The Journal of Organic Chemistry. 77: 6989-97. PMID 22804781 DOI: 10.1021/Jo301210F  0.355
2012 Dossetter AG, Beeley H, Bowyer J, Cook CR, Crawford JJ, Finlayson JE, Heron NM, Heyes C, Highton AJ, Hudson JA, Jestel A, Kenny PW, Krapp S, Martin S, MacFaul PA, et al. (1R,2R)-N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): a potent and highly selective cathepsin K inhibitor for the treatment of osteoarthritis. Journal of Medicinal Chemistry. 55: 6363-74. PMID 22742641 DOI: 10.1021/Jm3007257  0.545
2012 Pasqua AE, Crawford JJ, Long DL, Marquez R. Protecting group free, stereocontrolled synthesis of β-halo-enamides. The Journal of Organic Chemistry. 77: 2149-58. PMID 22263777 DOI: 10.1021/Jo202130E  0.406
2012 Armstrong DR, Balloch L, Crawford JJ, Fleming BJ, Hogg LM, Kennedy AR, Klett J, Mulvey RE, O'Hara CT, Orr SA, Robertson SD. Single electron transfer (SET) activity of the dialkyl-amido sodium zincate [(TMEDA)·Na(μ-TMP)(μ-tBu)Zn(tBu)] towards TEMPO and chalcone. Chemical Communications (Cambridge, England). 48: 1541-3. PMID 21687848 DOI: 10.1039/C1Cc12869H  0.442
2012 Pasqua AE, Ferrari FD, Crawford JJ, Marquez R. Formal synthesis of (+)-crocacin C Tetrahedron Letters. 53: 2114-2116. DOI: 10.1016/J.Tetlet.2012.02.049  0.392
2009 Mathieson JE, Crawford JJ, Schmidtmann M, Marquez R. Fast and efficient one step synthesis of dienamides. Organic & Biomolecular Chemistry. 7: 2170-5. PMID 19421456 DOI: 10.1039/B901797F  0.416
2009 MacFaul PA, Morley AD, Crawford JJ. A simple in vitro assay for assessing the reactivity of nitrile containing compounds. Bioorganic & Medicinal Chemistry Letters. 19: 1136-8. PMID 19168354 DOI: 10.1016/J.Bmcl.2008.12.105  0.359
2007 Nicolaou KC, Zhang H, Chen JS, Crawford JJ, Pasunoori L. Total synthesis and stereochemistry of uncialamycin. Angewandte Chemie (International Ed. in English). 46: 4704-7. PMID 17497617 DOI: 10.1002/Anie.200700917  0.507
2007 Nicolaou KC, Zhang H, Chen JS, Crawford JJ, Pasunoori L. Synthesis of Uncialamycin Synfacts. 2007: 1121-1121. DOI: 10.1055/S-2007-991197  0.512
2006 Crawford JJ, Henderson KW, Kerr WJ. Direct and efficient one-pot preparation of ketones from aldehydes using N-tert-butylphenylsulfinimidoyl chloride. Organic Letters. 8: 5073-6. PMID 17048846 DOI: 10.1021/Ol061903L  0.688
2006 Crawford JJ, Kerr WJ, McLaughlin M, Morrison AJ, Pauson PL, Thurston GJ. Use of a highly effective intramolecular Pauson-Khand cyclisation for the formal total synthesis of (±)-α- and β-cedrene by preparation of cedrone Tetrahedron. 62: 11360-11370. DOI: 10.1016/J.Tet.2006.05.044  0.671
2004 Bassindale MJ, Crawford JJ, Henderson KW, Kerr WJ. Application of polydentate chiral amines within magnesium-mediated asymmetric deprotonation reactions Tetrahedron Letters. 45: 4175-4179. DOI: 10.1016/J.Tetlet.2004.03.113  0.688
2003 Khan TA, Tripoli R, Crawford JJ, Martin CG, Murphy JA. Diethylphosphine oxide (DEPO): high-yielding and facile preparation of indolones in water. Organic Letters. 5: 2971-4. PMID 12889921 DOI: 10.1021/Ol035173I  0.52
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