William B Klimstra - Publications

Affiliations: 
Center for Vaccine Research University of Pittsburgh, Pittsburgh, PA, United States 

84 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Ma H, Adams LJ, Raju S, Sariol A, Kafai NM, Janova H, Klimstra WB, Fremont DH, Diamond MS. The low-density lipoprotein receptor promotes infection of multiple encephalitic alphaviruses. Nature Communications. 15: 246. PMID 38172096 DOI: 10.1038/s41467-023-44624-x  0.332
2023 Vasylieva I, Smith M, Jacoby M, Scarlet J, Aravind E, Zilberberg A, Ling T, Ropelewski A, Klimstra W, Logan R, Freyberg Z, Watson A. Scalable Analysis Pipeline for Mapping Brain Cells in Big Microscopy Data. Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada. 29: 993. PMID 37613788 DOI: 10.1093/micmic/ozad067.497  0.436
2022 Gardner CL, Sun C, Dunn MD, Gilliland TC, Trobaugh DW, Terada Y, Reed DS, Hartman AL, Klimstra WB. In Vitro and In Vivo Phenotypes of Venezuelan, Eastern and Western Equine Encephalitis Viruses Derived from cDNA Clones of Human Isolates. Viruses. 15. PMID 36680046 DOI: 10.3390/v15010005  0.36
2022 Ma H, Albe JR, Gilliland T, McMillen CM, Gardner CL, Boyles DA, Cottle EL, Dunn MD, Lundy JD, Salama N, O'Malley KJ, Pandrea I, Teichert T, Barrick S, Klimstra WB, et al. Long-term persistence of viral RNA and inflammation in the CNS of macaques exposed to aerosolized Venezuelan equine encephalitis virus. Plos Pathogens. 18: e1009946. PMID 35696423 DOI: 10.1371/journal.ppat.1009946  0.402
2022 Kafai NM, Williamson LE, Binshtein E, Sukupolvi-Petty S, Gardner CL, Liu J, Mackin S, Kim AS, Kose N, Carnahan RH, Jung A, Droit L, Reed DS, Handley SA, Klimstra WB, et al. Neutralizing antibodies protect mice against Venezuelan equine encephalitis virus aerosol challenge. The Journal of Experimental Medicine. 219. PMID 35297953 DOI: 10.1084/jem.20212532  0.31
2022 Alcorn MDH, Klimstra WB. Glycosaminoglycan binding by arboviruses: a cautionary tale. The Journal of General Virology. 103. PMID 35191823 DOI: 10.1099/jgv.0.001726  0.347
2021 Williamson LE, Reeder KM, Bailey K, Tran MH, Roy V, Fouch ME, Kose N, Trivette A, Nargi RS, Winkler ES, Kim AS, Gainza C, Rodriguez J, Armstrong E, Sutton RE, ... ... Klimstra WB, et al. Therapeutic alphavirus cross-reactive E1 human antibodies inhibit viral egress. Cell. 184: 4430-4446.e22. PMID 34416147 DOI: 10.1016/j.cell.2021.07.033  0.324
2021 Gilliland T, Liu Y, Li R, Dunn M, Cottle E, Terada Y, Ryckman Z, Alcorn M, Vasilatos S, Lundy J, Larson D, Wu H, Luke T, Bausch C, Egland K, ... ... Klimstra WB, et al. Protection of human ACE2 transgenic Syrian hamsters from SARS CoV-2 variants by human polyclonal IgG from hyper-immunized transchromosomic bovines. Biorxiv : the Preprint Server For Biology. PMID 34341790 DOI: 10.1101/2021.07.26.453840  0.318
2021 Liu Z, Wu H, Egland KA, Gilliland TC, Dunn MD, Luke TC, Sullivan EJ, Klimstra WB, Bausch CL, Whelan SPJ. Human immunoglobulin from transchromosomic bovines hyperimmunized with SARS-CoV-2 spike antigen efficiently neutralizes viral variants. Human Vaccines & Immunotherapeutics. 1-10. PMID 34228597 DOI: 10.1080/21645515.2021.1940652  0.319
2021 Albe JR, Ma H, Gilliland TH, McMillen CM, Gardner CL, Boyles DA, Cottle EL, Dunn MD, Lundy JD, O'Malley KJ, Salama N, Walters AW, Pandrea I, Teichert T, Klimstra WB, et al. Physiological and immunological changes in the brain associated with lethal eastern equine encephalitis virus in macaques. Plos Pathogens. 17: e1009308. PMID 33534855 DOI: 10.1371/journal.ppat.1009308  0.407
2020 Williamson LE, Gilliland T, Yadav PK, Binshtein E, Bombardi R, Kose N, Nargi RS, Sutton RE, Durie CL, Armstrong E, Carnahan RH, Walker LM, Kim AS, Fox JM, Diamond MS, ... ... Klimstra WB, et al. Human Antibodies Protect against Aerosolized Eastern Equine Encephalitis Virus Infection. Cell. PMID 33301709 DOI: 10.1016/j.cell.2020.11.011  0.386
2020 Ma H, Kim AS, Kafai NM, Earnest JT, Shah AP, Case JB, Basore K, Gilliland TC, Sun C, Nelson CA, Thackray LB, Klimstra WB, Fremont DH, Diamond MS. LDLRAD3 is a receptor for Venezuelan equine encephalitis virus. Nature. PMID 33208938 DOI: 10.1038/s41586-020-2915-3  0.407
2020 Hartman AL, Nambulli S, McMillen CM, White AG, Tilston-Lunel NL, Albe JR, Cottle E, Dunn MD, Frye LJ, Gilliland TH, Olsen EL, O'Malley KJ, Schwarz MM, Tomko JA, Walker RC, ... ... Klimstra WB, et al. SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and shedding of infectious virus from both respiratory and gastrointestinal tracts. Plos Pathogens. 16: e1008903. PMID 32946524 DOI: 10.1371/Journal.Ppat.1008903  0.434
2020 Bakovic A, Bhalla N, Kortchak S, Sun C, Zhou W, Ahmed A, Risner K, Klimstra WB, Narayanan A. Venezuelan Equine Encephalitis Virus nsP3 Phosphorylation Can Be Mediated by IKKβ Kinase Activity and Abrogation of Phosphorylation Inhibits Negative-Strand Synthesis. Viruses. 12. PMID 32933112 DOI: 10.3390/V12091021  0.409
2020 Klimstra WB, Tilston-Lunel NL, Nambulli S, Boslett J, McMillen CM, Gilliland T, Dunn MD, Sun C, Wheeler SE, Wells A, Hartman AL, McElroy AK, Reed DS, Rennick LJ, Duprex WP. SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected hospitalized COVID-19 patients. The Journal of General Virology. PMID 32821033 DOI: 10.1099/Jgv.0.001481  0.429
2020 Klimstra WB, Tilston-Lunel NL, Nambulli S, Boslett J, McMillen CM, Gilliland T, Dunn MD, Sun C, Wheeler SE, Wells A, Hartman AL, McElroy AK, Reed DS, Rennick LJ, Duprex WP. SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected, hospitalized COVID-19 patients. Biorxiv : the Preprint Server For Biology. PMID 32607507 DOI: 10.1101/2020.06.19.154930  0.335
2020 Ma H, Lundy JD, Cottle EL, O'Malley KJ, Trichel AM, Klimstra WB, Hartman AL, Reed DS, Teichert T. Applications of minimally invasive multimodal telemetry for continuous monitoring of brain function and intracranial pressure in macaques with acute viral encephalitis. Plos One. 15: e0232381. PMID 32584818 DOI: 10.1371/Journal.Pone.0232381  0.459
2020 Kim E, Erdos G, Huang S, Kenniston TW, Balmert SC, Carey CD, Raj VS, Epperly MW, Klimstra WB, Haagmans BL, Korkmaz E, Falo LD, Gambotto A. Microneedle array delivered recombinant coronavirus vaccines: Immunogenicity and rapid translational development. Ebiomedicine. 102743. PMID 32249203 DOI: 10.1016/J.Ebiom.2020.102743  0.429
2020 Chen CL, Hasan SS, Klose T, Sun Y, Buda G, Sun C, Klimstra WB, Rossmann MG. Cryo-EM structure of eastern equine encephalitis virus in complex with heparan sulfate analogues. Proceedings of the National Academy of Sciences of the United States of America. PMID 32245806 DOI: 10.1073/Pnas.1910670117  0.401
2020 Salimi H, Cain MD, Jiang X, Roth RA, Beatty WL, Sun C, Klimstra WB, Hou J, Klein RS. Encephalitic Alphaviruses Exploit Caveola-Mediated Transcytosis at the Blood-Brain Barrier for Central Nervous System Entry. Mbio. 11. PMID 32047126 DOI: 10.1128/Mbio.02731-19  0.507
2019 Ma H, Lundy JD, O'Malley KJ, Klimstra WB, Hartman AL, Reed ADS. Electrocardiography Abnormalities in Macaques after Infection with Encephalitic Alphaviruses. Pathogens (Basel, Switzerland). 8. PMID 31744158 DOI: 10.3390/Pathogens8040240  0.357
2019 Trobaugh DW, Sun C, Bhalla N, Gardner CL, Dunn M, Klimstra WB. Cooperativity between the 3' untranslated region microRNA binding sites is critical for the virulence of eastern equine encephalitis virus. Plos Pathogens. 15: e1007867. PMID 31658290 DOI: 10.1371/Journal.Ppat.1007867  0.447
2019 Bhalla N, Gardner CL, Downs SN, Dunn M, Sun C, Klimstra WB. Macromolecular synthesis shutoff resistance by myeloid cells is critical to IRF7-dependent systemic interferon alpha/beta induction after alphavirus infection. Journal of Virology. PMID 31578290 DOI: 10.1128/Jvi.00872-19  0.442
2019 Rusnak JM, Glass PJ, Weaver SC, Sabourin CL, Glenn AM, Klimstra W, Badorrek CS, Nasar F, Ward LA. Approach to Strain Selection and the Propagation of Viral Stocks for Venezuelan Equine Encephalitis Virus Vaccine Efficacy Testing under the Animal Rule. Viruses. 11. PMID 31480472 DOI: 10.3390/V11090807  0.39
2019 Bowling JD, O' Malley KJ, Klimstra WB, Hartman AL, Reed DS. A vibrating mesh nebulizer as an alternative to the Collison 3-jet nebulizer for infectious disease aerobiology. Applied and Environmental Microbiology. PMID 31253680 DOI: 10.1128/Aem.00747-19  0.363
2019 Trobaugh DW, Sun C, Dunn MD, Reed DS, Klimstra WB. Rational design of a live-attenuated eastern equine encephalitis virus vaccine through informed mutation of virulence determinants. Plos Pathogens. 15: e1007584. PMID 30742691 DOI: 10.1371/Journal.Ppat.1007584  0.447
2019 Saif Hasan S, Sun C, Kim A, Watanabe Y, Chen C, Klose T, Buda G, Crispin M, Diamond MS, Klimstra WB, Rossmann MG. Structural Insights into Entry and Antibody Neutralization of Eastern Equine Encephalitis Virus Biophysical Journal. 116: 576a. DOI: 10.1016/J.Bpj.2018.11.3095  0.383
2018 Hasan SS, Sun C, Kim AS, Watanabe Y, Chen CL, Klose T, Buda G, Crispin M, Diamond MS, Klimstra WB, Rossmann MG. Cryo-EM Structures of Eastern Equine Encephalitis Virus Reveal Mechanisms of Virus Disassembly and Antibody Neutralization. Cell Reports. 25: 3136-3147.e5. PMID 30540945 DOI: 10.1016/J.Celrep.2018.11.067  0.474
2018 Kim AS, Austin SK, Gardner CL, Zuiani A, Reed DS, Trobaugh DW, Sun C, Basore K, Williamson LE, Crowe JE, Slifka MK, Fremont DH, Klimstra WB, Diamond MS. Protective antibodies against Eastern equine encephalitis virus bind to epitopes in domains A and B of the E2 glycoprotein. Nature Microbiology. PMID 30455470 DOI: 10.1038/S41564-018-0286-4  0.405
2018 Walters AW, Kujawa MR, Albe JR, Reed DS, Klimstra WB, Hartman AL. Vascular permeability in the brain is a late pathogenic event during Rift Valley fever virus encephalitis in rats. Virology. 526: 173-179. PMID 30396029 DOI: 10.1016/J.Virol.2018.10.021  0.423
2018 Weiss CM, Trobaugh DW, Sun C, Lucas TM, Diamond MS, Ryman KD, Klimstra WB. The Interferon-Induced Exonuclease ISG20 Exerts Antiviral Activity through Upregulation of Type I Interferon Response Proteins. Msphere. 3. PMID 30232164 DOI: 10.1128/mSphere.00209-18  0.372
2018 Zhang R, Kim AS, Fox JM, Nair S, Basore K, Klimstra WB, Rimkunas R, Fong RH, Lin H, Poddar S, Crowe JE, Doranz BJ, Fremont DH, Diamond MS. Mxra8 is a receptor for multiple arthritogenic alphaviruses. Nature. PMID 29769725 DOI: 10.1038/S41586-018-0121-3  0.531
2018 Lane WC, Dunn MD, Gardner CL, Lam LKM, Watson AM, Hartman AL, Ryman KD, Klimstra WB. The Efficacy of the Interferon Alpha/Beta Response versus Arboviruses Is Temperature Dependent. Mbio. 9. PMID 29691338 DOI: 10.1128/Mbio.00535-18  0.561
2018 Lam LKM, Watson AM, Ryman KD, Klimstra WB. Gamma-interferon exerts a critical early restriction on replication and dissemination of yellow fever virus vaccine strain 17D-204. Npj Vaccines. 3: 5. PMID 29387474 DOI: 10.1038/s41541-017-0039-z  0.625
2017 Prow NA, Tang B, Gardner J, Le TT, Taylor A, Poo YS, Nakayama E, Hirata TDC, Nakaya HI, Slonchak A, Mukhopadhyay P, Mahalingam S, Schroder WA, Klimstra W, Suhrbier A. Lower temperatures reduce type I interferon activity and promote alphaviral arthritis. Plos Pathogens. 13: e1006788. PMID 29281739 DOI: 10.1371/Journal.Ppat.1006788  0.413
2017 Watson AM, Rose AH, Gibson GA, Gardner CL, Sun C, Reed DS, Lam LKM, St Croix CM, Strick PL, Klimstra WB, Watkins SC. Ribbon scanning confocal for high-speed high-resolution volume imaging of brain. Plos One. 12: e0180486. PMID 28686653 DOI: 10.1371/Journal.Pone.0180486  0.536
2017 Dumont TMF, Mouillet JF, Bayer A, Gardner CL, Klimstra WB, Wolf DG, Yagel S, Balmir F, Binstock A, Sanfilippo JS, Coyne CB, Larkin JC, Sadovsky Y. The expression level of C19MC miRNAs in early pregnancy and in response to viral infection. Placenta. 53: 23-29. PMID 28487016 DOI: 10.1016/J.Placenta.2017.03.011  0.309
2017 Gardner CL, Sun C, Luke T, Raviprakash K, Wu H, Jiao JA, Sullivan E, Reed DS, Ryman KD, Klimstra WB. Antibody preparations from human transchromosomic cows exhibit prophylactic and therapeutic efficacy versus Venezuelan equine encephalitis virus. Journal of Virology. PMID 28468884 DOI: 10.1128/Jvi.00226-17  0.489
2017 Watson AM, Klimstra WB. T Cell-Mediated Immunity towards Yellow Fever Virus and Useful Animal Models. Viruses. 9. PMID 28398253 DOI: 10.3390/V9040077  0.624
2017 Trobaugh DW, Klimstra WB. Alphaviruses suppress host immunity by preventing myeloid cell replication and antagonizing innate immune responses. Current Opinion in Virology. 23: 30-34. PMID 28288385 DOI: 10.1016/J.Coviro.2017.02.004  0.44
2017 Trobaugh DW, Klimstra WB. MicroRNA Regulation of RNA Virus Replication and Pathogenesis. Trends in Molecular Medicine. 23: 80-93. PMID 27989642 DOI: 10.1016/J.Molmed.2016.11.003  0.392
2016 Troupin A, Shirley D, Londono-Renteria B, Watson AM, McHale C, Hall A, Hartstone-Rose A, Klimstra WB, Gomez G, Colpitts TM. A Role for Human Skin Mast Cells in Dengue Virus Infection and Systemic Spread. Journal of Immunology (Baltimore, Md. : 1950). PMID 27799312 DOI: 10.4049/Jimmunol.1600846  0.611
2016 Conway MJ, Londono-Renteria B, Troupin A, Watson AM, Klimstra WB, Fikrig E, Colpitts TM. Aedes aegypti D7 Saliva Protein Inhibits Dengue Virus Infection. Plos Neglected Tropical Diseases. 10: e0004941. PMID 27632170 DOI: 10.1371/Journal.Pntd.0004941  0.62
2016 Watson AM, Lam LK, Klimstra WB, Ryman KD. The 17D-204 Vaccine Strain-Induced Protection against Virulent Yellow Fever Virus Is Mediated by Humoral Immunity and CD4+ but not CD8+ T Cells. Plos Pathogens. 12: e1005786. PMID 27463517 DOI: 10.1371/Journal.Ppat.1005786  0.571
2016 Bhalla N, Sun C, Metthew Lam LK, Gardner CL, Ryman KD, Klimstra WB. Host translation shutoff mediated by non-structural protein 2 is a critical factor in the antiviral state resistance of Venezuelan equine encephalitis virus. Virology. 496: 147-165. PMID 27318152 DOI: 10.1016/J.Virol.2016.06.005  0.41
2016 Gardner CL, Trobaugh DW, Ryman KD, Klimstra WB. Electroporation of Alphavirus RNA Translational Reporters into Fibroblastic and Myeloid Cells as a Tool to Study the Innate Immune System. Methods in Molecular Biology (Clifton, N.J.). 1428: 127-37. PMID 27236796 DOI: 10.1007/978-1-4939-3625-0_8  0.426
2015 Dalmia N, Klimstra WB, Mason C, Ramsay AJ. DNA-Launched Alphavirus Replicons Encoding a Fusion of Mycobacterial Antigens Acr and Ag85B Are Immunogenic and Protective in a Murine Model of TB Infection. Plos One. 10: e0136635. PMID 26317509 DOI: 10.1371/Journal.Pone.0136635  0.368
2015 Hyde JL, Chen R, Trobaugh DW, Diamond MS, Weaver SC, Klimstra WB, Wilusz J. The 5' and 3' ends of alphavirus RNAs - Non-coding is not non-functional. Virus Research. 206: 99-107. PMID 25630058 DOI: 10.1016/J.Virusres.2015.01.016  0.371
2015 Bayer A, Delorme-Axford E, Sleigher C, Frey TK, Trobaugh DW, Klimstra WB, Emert-Sedlak LA, Smithgall TE, Kinchington PR, Vadia S, Seveau S, Boyle JP, Coyne CB, Sadovsky Y. Human trophoblasts confer resistance to viruses implicated in perinatal infection. American Journal of Obstetrics and Gynecology. 212: 71.e1-8. PMID 25108145 DOI: 10.1016/J.Ajog.2014.07.060  0.438
2014 Trobaugh DW, Ryman KD, Klimstra WB. Can understanding the virulence mechanisms of RNA viruses lead us to a vaccine against eastern equine encephalitis virus and other alphaviruses? Expert Review of Vaccines. 13: 1423-5. PMID 25073901 DOI: 10.1586/14760584.2014.944168  0.421
2014 Ryman KD, Klimstra WB. Closing the gap between viral and noninfectious arthritis. Proceedings of the National Academy of Sciences of the United States of America. 111: 5767-8. PMID 24733902 DOI: 10.1073/Pnas.1404206111  0.464
2014 Gardner CL, Hritz J, Sun C, Vanlandingham DL, Song TY, Ghedin E, Higgs S, Klimstra WB, Ryman KD. Deliberate attenuation of chikungunya virus by adaptation to heparan sulfate-dependent infectivity: a model for rational arboviral vaccine design. Plos Neglected Tropical Diseases. 8: e2719. PMID 24587470 DOI: 10.1371/Journal.Pntd.0002719  0.512
2014 Hyde JL, Gardner CL, Kimura T, White JP, Liu G, Trobaugh DW, Huang C, Tonelli M, Paessler S, Takeda K, Klimstra WB, Amarasinghe GK, Diamond MS. A viral RNA structural element alters host recognition of nonself RNA. Science (New York, N.Y.). 343: 783-7. PMID 24482115 DOI: 10.1126/Science.1248465  0.378
2014 Trobaugh DW, Gardner CL, Sun C, Haddow AD, Wang E, Chapnik E, Mildner A, Weaver SC, Ryman KD, Klimstra WB. RNA viruses can hijack vertebrate microRNAs to suppress innate immunity. Nature. 506: 245-8. PMID 24352241 DOI: 10.1038/Nature12869  0.427
2014 Sun C, Gardner CL, Watson AM, Ryman KD, Klimstra WB. Stable, high-level expression of reporter proteins from improved alphavirus expression vectors to track replication and dissemination during encephalitic and arthritogenic disease. Journal of Virology. 88: 2035-46. PMID 24307590 DOI: 10.1128/Jvi.02990-13  0.633
2014 Conway MJ, Watson AM, Colpitts TM, Dragovic SM, Li Z, Wang P, Feitosa F, Shepherd DT, Ryman KD, Klimstra WB, Anderson JF, Fikrig E. Mosquito saliva serine protease enhances dissemination of dengue virus into the mammalian host. Journal of Virology. 88: 164-75. PMID 24131723 DOI: 10.1128/Jvi.02235-13  0.659
2013 Gardner CL, Choi-Nurvitadhi J, Sun C, Bayer A, Hritz J, Ryman KD, Klimstra WB. Natural variation in the heparan sulfate binding domain of the eastern equine encephalitis virus E2 glycoprotein alters interactions with cell surfaces and virulence in mice. Journal of Virology. 87: 8582-90. PMID 23720725 DOI: 10.1128/Jvi.00937-13  0.351
2012 Gardner CL, Burke CW, Higgs ST, Klimstra WB, Ryman KD. Interferon-alpha/beta deficiency greatly exacerbates arthritogenic disease in mice infected with wild-type chikungunya virus but not with the cell culture-adapted live-attenuated 181/25 vaccine candidate. Virology. 425: 103-12. PMID 22305131 DOI: 10.1016/J.Virol.2011.12.020  0.502
2011 Gardner CL, Ebel GD, Ryman KD, Klimstra WB. Heparan sulfate binding by natural eastern equine encephalitis viruses promotes neurovirulence Proceedings of the National Academy of Sciences of the United States of America. 108: 16026-16031. PMID 21896745 DOI: 10.1073/Pnas.1110617108  0.418
2010 Daffis S, Szretter KJ, Schriewer J, Li J, Youn S, Errett J, Lin TY, Schneller S, Zust R, Dong H, Thiel V, Sen GC, Fensterl V, Klimstra WB, Pierson TC, et al. 2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members. Nature. 468: 452-6. PMID 21085181 DOI: 10.1038/Nature09489  0.353
2010 Zhang XY, Kutner RH, Bialkowska A, Marino MP, Klimstra WB, Reiser J. Cell-specific targeting of lentiviral vectors mediated by fusion proteins derived from Sindbis virus, vesicular stomatitis virus, or avian sarcoma/leukosis virus. Retrovirology. 7: 3. PMID 20100344 DOI: 10.1186/1742-4690-7-3  0.431
2009 Meier KC, Gardner CL, Khoretonenko MV, Klimstra WB, Ryman KD. A mouse model for studying viscerotropic disease caused by yellow fever virus infection. Plos Pathogens. 5: e1000614. PMID 19816561 DOI: 10.1371/Journal.Ppat.1000614  0.507
2009 Burke CW, Gardner CL, Steffan JJ, Ryman KD, Klimstra WB. Characteristics of alpha/beta interferon induction after infection of murine fibroblasts with wild-type and mutant alphaviruses. Virology. 395: 121-32. PMID 19782381 DOI: 10.1016/J.Virol.2009.08.039  0.409
2009 Yin J, Gardner CL, Burke CW, Ryman KD, Klimstra WB. Similarities and differences in antagonism of neuron alpha/beta interferon responses by Venezuelan equine encephalitis and Sindbis alphaviruses. Journal of Virology. 83: 10036-47. PMID 19641001 DOI: 10.1128/Jvi.01209-09  0.407
2009 Gardner CL, Yin J, Burke CW, Klimstra WB, Ryman KD. Type I interferon induction is correlated with attenuation of a South American eastern equine encephalitis virus strain in mice. Virology. 390: 338-47. PMID 19539968 DOI: 10.1016/J.Virol.2009.05.030  0.419
2008 Ryman KD, Klimstra WB. Host responses to alphavirus infection. Immunological Reviews. 225: 27-45. PMID 18837774 DOI: 10.1111/J.1600-065X.2008.00670.X  0.489
2008 Gardner CL, Burke CW, Tesfay MZ, Glass PJ, Klimstra WB, Ryman KD. Eastern and Venezuelan equine encephalitis viruses differ in their ability to infect dendritic cells and macrophages: impact of altered cell tropism on pathogenesis. Journal of Virology. 82: 10634-46. PMID 18768986 DOI: 10.1128/Jvi.01323-08  0.479
2008 Tesfay MZ, Yin J, Gardner CL, Khoretonenko MV, Korneeva NL, Rhoads RE, Ryman KD, Klimstra WB. Alpha/beta interferon inhibits cap-dependent translation of viral but not cellular mRNA by a PKR-independent mechanism. Journal of Virology. 82: 2620-30. PMID 18160435 DOI: 10.1128/Jvi.01784-07  0.404
2007 Zhang Y, Burke CW, Ryman KD, Klimstra WB. Identification and characterization of interferon-induced proteins that inhibit alphavirus replication. Journal of Virology. 81: 11246-55. PMID 17686841 DOI: 10.1128/Jvi.01282-07  0.419
2007 Ryman KD, Meier KC, Gardner CL, Adegboyega PA, Klimstra WB. Non-pathogenic Sindbis virus causes hemorrhagic fever in the absence of alpha/beta and gamma interferons. Virology. 368: 273-85. PMID 17681583 DOI: 10.1016/J.Virol.2007.06.039  0.429
2007 Ryman KD, Gardner CL, Meier KC, Biron CA, Johnston RE, Klimstra WB. Early restriction of alphavirus replication and dissemination contributes to age-dependent attenuation of systemic hyperinflammatory disease. The Journal of General Virology. 88: 518-29. PMID 17251570 DOI: 10.1099/Vir.0.82359-0  0.522
2007 Ryman KD, Gardner CL, Burke CW, Meier KC, Thompson JM, Klimstra WB. Heparan sulfate binding can contribute to the neurovirulence of neuroadapted and nonneuroadapted Sindbis viruses. Journal of Virology. 81: 3563-73. PMID 17215278 DOI: 10.1128/Jvi.02494-06  0.391
2005 Klimstra WB, Williams JC, Ryman KD, Heidner HW. Targeting Sindbis virus-based vectors to Fc receptor-positive cell types. Virology. 338: 9-21. PMID 15922395 DOI: 10.1016/J.Virol.2005.04.039  0.421
2005 Ryman KD, Meier KC, Nangle EM, Ragsdale SL, Korneeva NL, Rhoads RE, MacDonald MR, Klimstra WB. Sindbis virus translation is inhibited by a PKR/RNase L-independent effector induced by alpha/beta interferon priming of dendritic cells. Journal of Virology. 79: 1487-99. PMID 15650175 DOI: 10.1128/JVI.79.3.1487-1499.2005  0.332
2005 ALEXANDER N, TURAKHIA A, AMIRGHAHARI N, NATHAN C, KLIMSTRA W, RYMAN K. Sindbis Virus As a Novel Oncolytic Vector for Virotherapy of Head and Neck Cancer Otolaryngology - Head and Neck Surgery. 133: P97-P98. DOI: 10.1016/J.Otohns.2005.05.206  0.347
2004 Ryman KD, Klimstra WB, Johnston RE. Attenuation of Sindbis virus variants incorporating uncleaved PE2 glycoprotein is correlated with attachment to cell-surface heparan sulfate. Virology. 322: 1-12. PMID 15063111 DOI: 10.1016/J.Virol.2004.01.003  0.45
2003 Klimstra WB, Nangle EM, Smith MS, Yurochko AD, Ryman KD. DC-SIGN and L-SIGN Can Act as Attachment Receptors for Alphaviruses and Distinguish between Mosquito Cell- and Mammalian Cell-Derived Viruses Journal of Virology. 77: 12022-12032. PMID 14581539 DOI: 10.1128/Jvi.78.14.7862.2004  0.452
2003 Thomas JM, Klimstra WB, Ryman KD, Heidner HW. Sindbis virus vectors designed to express a foreign protein as a cleavable component of the viral structural polyprotein. Journal of Virology. 77: 5598-606. PMID 12719552 DOI: 10.1128/Jvi.77.10.5598-5606.2003  0.402
2002 Ryman KD, White LJ, Johnston RE, Klimstra WB. Effects of PKR/RNase L-dependent and alternative antiviral pathways on alphavirus replication and pathogenesis. Viral Immunology. 15: 53-76. PMID 11952147 DOI: 10.1089/088282402317340233  0.45
2001 Smit JM, Klimstra WB, Ryman KD, Bittman R, Johnston RE, Wilschut J. PE2 cleavage mutants of Sindbis virus: correlation between viral infectivity and pH-dependent membrane fusion activation of the spike heterodimer. Journal of Virology. 75: 11196-204. PMID 11602759 DOI: 10.1128/Jvi.75.22.11196-11204.2001  0.333
2000 Bernard KA, Klimstra WB, Johnston RE. Mutations in the E2 glycoprotein of Venezuelan equine encephalitis virus confer heparan sulfate interaction, low morbidity, and rapid clearance from blood of mice. Virology. 276: 93-103. PMID 11021998 DOI: 10.1006/Viro.2000.0546  0.334
2000 Ryman KD, Klimstra WB, Nguyen KB, Biron CA, Johnston RE. Alpha/beta interferon protects adult mice from fatal Sindbis virus infection and is an important determinant of cell and tissue tropism. Journal of Virology. 74: 3366-78. PMID 10708454 DOI: 10.1128/Jvi.74.7.3366-3378.2000  0.352
1999 Klimstra WB, Ryman KD, Bernard KA, Nguyen KB, Biron CA, Johnston RE. Infection of neonatal mice with sindbis virus results in a systemic inflammatory response syndrome. Journal of Virology. 73: 10387-98. PMID 10559357 DOI: 10.1128/Jvi.73.12.10387-10398.1999  0.342
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