Ashraf brik - Publications

Affiliations: 
Chemistry Technion - Israel Institute of Technology, Haifa, Haifa District, Israel 

104 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Msallam M, Sun H, Meledin R, Franz P, Brik A. Examining the role of phosphorylation of p19 in its stability and ubiquitination using chemical protein synthesis. Chemical Science. 11: 5526-5531. PMID 32874495 DOI: 10.1039/c9sc06300e  0.4
2020 Jbara M, Eid E, Brik A. Gold(I)-Mediated Decaging or Cleavage of Propargylated Peptide Bond in Aqueous Conditions for Protein Synthesis and Manipulation. Journal of the American Chemical Society. PMID 32290655 DOI: 10.1021/jacs.9b13216  0.64
2020 Eid E, Boross GN, Sun H, Msallam M, Singh SK, Brik A. Total Chemical Synthesis of ISGylated-Ubiquitin Hybrid Chain Assisted by Acetamidomethyl Derivatives with Dual Functions. Bioconjugate Chemistry. PMID 32069038 DOI: 10.1021/acs.bioconjchem.0c00026  0.4
2019 Sun H, Brik A. The Journey for the Total Chemical Synthesis of a 53 kDa Protein. Accounts of Chemical Research. PMID 31536331 DOI: 10.1021/acs.accounts.9b00372  0.36
2019 Mann G, Satish G, Meledin R, Vamisetti GB, Brik A. Palladium-Mediated Cleavage of Proteins with Thiazolidine-Modified Backbone in Live Cells. Angewandte Chemie (International Ed. in English). 58: 13540-13549. PMID 31402546 DOI: 10.1002/anie.201906545  0.48
2019 Nawatha M, Rogers JM, Bonn SM, Livneh I, Lemma B, Mali SM, Vamisetti GB, Sun H, Bercovich B, Huang Y, Ciechanover A, Fushman D, Suga H, Brik A. De novo macrocyclic peptides that specifically modulate Lys48-linked ubiquitin chains. Nature Chemistry. PMID 31182821 DOI: 10.1038/s41557-019-0278-x  0.64
2019 Meledin R, Brik A. Mirroring Life's Building Blocks. Cell Chemical Biology. 26: 616-619. PMID 31100259 DOI: 10.1016/j.chembiol.2019.04.013  0.4
2019 Sun H, Mali SM, Singh SK, Meledin R, Brik A, Kwon YT, Kravtsova-Ivantsiv Y, Bercovich B, Ciechanover A. Diverse fate of ubiquitin chain moieties: The proximal is degraded with the target, and the distal protects the proximal from removal and recycles. Proceedings of the National Academy of Sciences of the United States of America. PMID 30867293 DOI: 10.1073/pnas.1822148116  0.64
2019 Morgan M, Jbara M, Brik A, Wolberger C. Semisynthesis of ubiquitinated histone H2B with a native or nonhydrolyzable linkage. Methods in Enzymology. 618: 1-27. PMID 30850047 DOI: 10.1016/bs.mie.2019.01.003  0.64
2019 Brik A, Laps S, Sun H, Kamnesky G. Palladium Mediated Direct Disulfide Bond Formation in Proteins Containing S-Acetamidomethyl-Cysteine under Aqueous Conditions. Angewandte Chemie (International Ed. in English). PMID 30828918 DOI: 10.1002/anie.201900988  0.48
2019 Nune M, Morgan MT, Connell Z, McCullough L, Jbara M, Sun H, Brik A, Formosa T, Wolberger C. FACT and Ubp10 collaborate to modulate H2B deubiquitination and nucleosome dynamics. Elife. 8. PMID 30681413 DOI: 10.7554/eLife.40988  0.64
2019 Vamisetti GB, Meledin R, Gopinath P, Brik A. Halogen Substituents in the Isoquinoline Scaffold Switches the Selectivity of Inhibition between USP2 and USP7. Chembiochem : a European Journal of Chemical Biology. 20: 282-286. PMID 30474907 DOI: 10.1002/cbic.201800612  0.4
2018 Jbara M, Laps S, Morgan M, Kamnesky G, Mann G, Wolberger C, Brik A. Palladium prompted on-demand cysteine chemistry for the synthesis of challenging and uniquely modified proteins. Nature Communications. 9: 3154. PMID 30089783 DOI: 10.1038/s41467-018-05628-0  0.64
2018 Jbara M, Eid E, Brik A. Palladium mediated deallylation in fully aqueous conditions for native chemical ligation at aspartic and glutamic acid sites. Organic & Biomolecular Chemistry. PMID 29766191 DOI: 10.1039/c8ob00890f  0.64
2018 Sun H, Meledin R, Mali SM, Brik A. Total chemical synthesis of ester-linked ubiquitinated proteins unravels their behavior with deubiquitinases. Chemical Science. 9: 1661-1665. PMID 29675213 DOI: 10.1039/c7sc04518b  0.64
2018 Brik A, Meledin R, Mali S, Kleifeld O. Activity-Based Probes Developed by Applying Sequential Dehydroalanine Strategy on Expressed Proteins Reveal a Potential α-globin Modulating Deubiquitinase. Angewandte Chemie (International Ed. in English). PMID 29527788 DOI: 10.1002/anie.201800032  0.4
2018 Jbara M, Sun H, Kamnesky G, Brik A. Chemical chromatin ubiquitylation. Current Opinion in Chemical Biology. 45: 18-26. PMID 29459258 DOI: 10.1016/j.cbpa.2018.02.001  0.64
2017 Bondalapati S, Eid E, Mali SM, Wolberger C, Brik A. Total chemical synthesis of SUMO-2-Lys63-linked diubiquitin hybrid chains assisted by removable solubilizing tags. Chemical Science. 8: 4027-4034. PMID 28580118 DOI: 10.1039/c7sc00488e  0.64
2017 Jbara M, Guttmann-Raviv N, Maity SK, Ayoub N, Brik A. Total chemical synthesis of methylated analogues of histone 3 revealed KDM4D as a potential regulator of H3K79me3. Bioorganic & Medicinal Chemistry. PMID 28434780 DOI: 10.1016/j.bmc.2017.04.015  0.64
2017 Brik A, Maity SK, Jbara M. Palladium in Chemical Protein Synthesis and Modifications. Angewandte Chemie (International Ed. in English). PMID 28383786 DOI: 10.1002/anie.201702370  0.64
2017 Mali SM, Singh SK, Eid E, Brik A. Ubiquitin Signalling: Chemistry Comes to Rescue. Journal of the American Chemical Society. PMID 28328208 DOI: 10.1021/jacs.7b00089  0.64
2016 Singh SK, Sahu I, Mali SM, Hemantha HP, Kleifeld O, Glickman MH, Brik A. Synthetic Uncleavable Ubiquitinated Proteins Dissect Proteasome Deubiquitination and Degradation, and Highlight Distinctive Fate of Tetraubiquitin. Journal of the American Chemical Society. 138: 16004-16015. PMID 27960333 DOI: 10.1021/jacs.6b09611  0.64
2016 Jbara M, Laps S, Maity SK, Brik A. Palladium-Assisted Cleavage of Peptides and Proteins Containing a Backbone with Thiazolidine Linkage. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27550063 DOI: 10.1002/chem.201603676  0.64
2016 Maity SK, Mann G, Jbara M, Laps S, Kamnesky G, Brik A. Palladium-Assisted Removal of a Solubilizing Tag from a Cys Side Chain To Facilitate Peptide and Protein Synthesis. Organic Letters. PMID 27268382 DOI: 10.1021/acs.orglett.6b01442  0.64
2016 Meledin R, Mali SM, Singh SK, Brik A. Protein ubiquitination via dehydroalanine: development and insights into the diastereoselective 1,4-addition step. Organic & Biomolecular Chemistry. PMID 27143624 DOI: 10.1039/c6ob00882h  0.64
2016 Maity SK, Jbara M, Laps S, Brik A. Efficient Palladium-Assisted One-Pot Deprotection of (Acetamidomethyl)Cysteine Following Native Chemical Ligation and/or Desulfurization To Expedite Chemical Protein Synthesis. Angewandte Chemie (International Ed. in English). PMID 27126503 DOI: 10.1002/anie.201603169  0.64
2016 Bondalapati S, Jbara M, Brik A. Expanding the chemical toolbox for the synthesis of large and uniquely modified proteins. Nature Chemistry. 8: 407-18. PMID 27102674 DOI: 10.1038/nchem.2476  0.64
2016 Jbara M, Maity SK, Seenaiah M, Brik A. Palladium Mediated Rapid Deprotection of N-Terminal Cysteine under Native Chemical Ligation Conditions for the Efficient Preparation of Synthetically Challenging Proteins. Journal of the American Chemical Society. 138: 5069-75. PMID 27023072 DOI: 10.1021/jacs.5b13580  0.64
2016 Jbara M, Maity SK, Morgan M, Wolberger C, Brik A. Chemical Synthesis of Phosphorylated Histone H2A at Tyr57 Reveals Insight into the Inhibition Mode of the SAGA Deubiquitinating Module. Angewandte Chemie (International Ed. in English). PMID 26960207 DOI: 10.1002/anie.201600638  0.64
2016 Morgan MT, Haj-Yahya M, Ringel AE, Bandi P, Brik A, Wolberger C. Structural basis for histone H2B deubiquitination by the SAGA DUB module. Science (New York, N.Y.). 351: 725-8. PMID 26912860 DOI: 10.1126/science.aac5681  0.64
2016 Maity SK, Jbara M, Brik A. Chemical and semisynthesis of modified histones. Journal of Peptide Science : An Official Publication of the European Peptide Society. PMID 26778211 DOI: 10.1002/psc.2848  0.64
2016 Meledin R, Mali SM, Brik A. Pushing the Boundaries of Chemical Protein Synthesis: The Case of Ubiquitin Chains and Polyubiquitinated Peptides and Proteins. Chemical Record (New York, N.Y.). 16: 509-19. PMID 26477936 DOI: 10.1002/tcr.201500209  0.64
2016 Meledin R, Mali SM, Brik A. Pushing the Boundaries of Chemical Protein Synthesis: The Case of Ubiquitin Chains and Polyubiquitinated Peptides and Proteins Chemical Record. 16: 509-519. DOI: 10.1002/tcr.201500209  0.64
2015 Hemantha HP, Bondalapati S, Singh SK, Brik A. Chemical Synthesis of Ubiquitin Chains. Current Protocols in Chemical Biology. 7: 229-48. PMID 26629614 DOI: 10.1002/9780470559277.ch150099  0.4
2015 Ohayon S, Refua M, Brik A. Rapid optimization of labeled ubiquitinated peptides for monitoring deubiquitinases activities. Organic & Biomolecular Chemistry. 13: 8182-6. PMID 26160015 DOI: 10.1039/c5ob01142f  0.64
2015 Maity SK, Ohayon S, Brik A. Synthesis of N-Hydroxy Isopeptide Containing Proteins. Organic Letters. 17: 3438-41. PMID 26111051 DOI: 10.1021/acs.orglett.5b01443  0.64
2015 Seenaiah M, Jbara M, Mali SM, Brik A. Convergent versus sequential protein synthesis: the case of ubiquitinated and glycosylated H2B. Angewandte Chemie (International Ed. in English). 54: 12374-8. PMID 26079184 DOI: 10.1002/anie.201503309  0.64
2015 Kravtsova-Ivantsiv Y, Shomer I, Cohen-Kaplan V, Snijder B, Superti-Furga G, Gonen H, Sommer T, Ziv T, Admon A, Naroditsky I, Jbara M, Brik A, Pikarsky E, Kwon YT, Doweck I, et al. KPC1-mediated ubiquitination and proteasomal processing of NF-κB1 p105 to p50 restricts tumor growth. Cell. 161: 333-47. PMID 25860612 DOI: 10.1016/j.cell.2015.03.001  0.64
2015 Bondalapati S, Mansour W, Nakasone MA, Maity SK, Glickman MH, Brik A. Chemical synthesis of phosphorylated ubiquitin and diubiquitin exposes positional sensitivities of e1-e2 enzymes and deubiquitinases. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 7360-4. PMID 25829361 DOI: 10.1002/chem.201500540  0.64
2015 Seenaiah M, Jbara M, Mali SM, Brik A. Convergent Versus Sequential Protein Synthesis: The Case of Ubiquitinated and Glycosylated H2B Angewandte Chemie - International Edition. 54: 12374-12378. DOI: 10.1002/anie.201503309  0.64
2014 Becker CF, Brik A, Dawson P, Hackenberger CP. Chemical protein synthesis. Journal of Peptide Science : An Official Publication of the European Peptide Society. 20: 63. PMID 25975419 DOI: 10.1002/psc.2607  0.64
2014 Bondalapati S, Ruvinov E, Kryukov O, Cohen S, Brik A. Rapid End-Group Modification of Polysaccharides for Biomaterial Applications in Regenerative Medicine. Macromolecular Rapid Communications. PMID 25220432 DOI: 10.1002/marc.201400354  0.4
2014 Jbara M, Seenaiah M, Brik A. Solid phase chemical ligation employing a rink amide linker for the synthesis of histone H2B protein Chemical Communications. 50: 12534-12537. PMID 25196573 DOI: 10.1039/c4cc06499b  0.64
2014 Krutauz D, Reis N, Nakasone MA, Siman P, Zhang D, Kirkpatrick DS, Gygi SP, Brik A, Fushman D, Glickman MH. Extended ubiquitin species are protein-based DUB inhibitors. Nature Chemical Biology. 10: 664-70. PMID 24997605 DOI: 10.1038/nchembio.1574  0.64
2014 Long L, Thelen JP, Furgason M, Haj-Yahya M, Brik A, Cheng D, Peng J, Yao T. The U4/U6 recycling factor SART3 has histone chaperone activity and associates with USP15 to regulate H2B deubiquitination. The Journal of Biological Chemistry. 289: 8916-30. PMID 24526689 DOI: 10.1074/jbc.M114.551754  0.64
2014 Hemantha HP, Bavikar SN, Herman-Bachinsky Y, Haj-Yahya N, Bondalapati S, Ciechanover A, Brik A. Nonenzymatic polyubiquitination of expressed proteins. Journal of the American Chemical Society. 136: 2665-73. PMID 24437386 DOI: 10.1021/ja412594d  0.64
2014 Haj-Yahya N, Hemantha HP, Meledin R, Bondalapati S, Seenaiah M, Brik A. Dehydroalanine-based diubiquitin activity probes Organic Letters. 16: 540-543. PMID 24364494 DOI: 10.1021/ol403416w  0.64
2013 Haj-Yahya M, Fauvet B, Herman-Bachinsky Y, Hejjaoui M, Bavikar SN, Karthikeyan SV, Ciechanover A, Lashuel HA, Brik A. Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology. Proceedings of the National Academy of Sciences of the United States of America. 110: 17726-31. PMID 24043770 DOI: 10.1073/pnas.1315654110  0.64
2013 Haj-Yahya N, Haj-Yahya M, Castañeda CA, Spasser L, Hemantha HP, Jbara M, Penner M, Ciechanover A, Fushman D, Brik A. Modifying the vicinity of the isopeptide bond to reveal differential behavior of ubiquitin chains with interacting proteins: organic chemistry applied to synthetic proteins. Angewandte Chemie (International Ed. in English). 52: 11149-53. PMID 24006204 DOI: 10.1002/anie.201306118  0.64
2013 Fauvet B, Butterfield SM, Fuks J, Brik A, Lashuel HA. One-pot total chemical synthesis of human α-synuclein. Chemical Communications (Cambridge, England). 49: 9254-6. PMID 23995579 DOI: 10.1039/c3cc45353g  0.64
2013 Shema-Yaacoby E, Nikolov M, Haj-Yahya M, Siman P, Allemand E, Yamaguchi Y, Muchardt C, Urlaub H, Brik A, Oren M, Fischle W. Systematic identification of proteins binding to chromatin-embedded ubiquitylated H2B reveals recruitment of SWI/SNF to regulate transcription. Cell Reports. 4: 601-8. PMID 23933260 DOI: 10.1016/j.celrep.2013.07.014  0.64
2013 Siman P, Karthikeyan SV, Nikolov M, Fischle W, Brik A. Convergent chemical synthesis of histone H2B protein for the site-specific ubiquitination at Lys34. Angewandte Chemie (International Ed. in English). 52: 8059-63. PMID 23794525 DOI: 10.1002/anie.201303844  0.64
2013 Brik A. Chemistry and biology of peptides, proteins and beyond Bioorganic and Medicinal Chemistry. 21: 3398-3399. PMID 23706510 DOI: 10.1016/j.bmc.2013.05.020  0.64
2013 Hemantha HP, Brik A. Non-enzymatic synthesis of ubiquitin chains: Where chemistry makes a difference Bioorganic and Medicinal Chemistry. 21: 3411-3420. PMID 23465437 DOI: 10.1016/j.bmc.2013.02.004  0.64
2013 Meledin R, Brik A, Aharoni A. Dissecting the Roles of the N- and C-Flanking Residues of Acetyllysine Substrates for SIRT1 Activity Chembiochem. 14: 577-581. PMID 23426869 DOI: 10.1002/cbic.201200727  0.64
2012 Haj-Yahya M, Eltarteer N, Ohayon S, Shema E, Kotler E, Oren M, Brik A. N-methylation of isopeptide bond as a strategy to resist deubiquitinases. Angewandte Chemie (International Ed. in English). 51: 11535-9. PMID 23065695 DOI: 10.1002/anie.201205771  0.64
2012 Moyal T, Bavikar SN, Karthikeyan SV, Hemantha HP, Brik A. Polymerization behavior of a bifunctional ubiquitin monomer as a function of the nucleophile site and folding conditions. Journal of the American Chemical Society. 134: 16085-92. PMID 22963682 DOI: 10.1021/ja3078736  0.64
2012 Shabek N, Herman-Bachinsky Y, Buchsbaum S, Lewinson O, Haj-Yahya M, Hejjaoui M, Lashuel HA, Sommer T, Brik A, Ciechanover A. The size of the proteasomal substrate determines whether its degradation will be mediated by mono- or polyubiquitylation. Molecular Cell. 48: 87-97. PMID 22902562 DOI: 10.1016/j.molcel.2012.07.011  0.64
2012 Spasser L, Brik A. Chemistry and biology of the ubiquitin signal Angewandte Chemie - International Edition. 51: 6840-6862. PMID 22696461 DOI: 10.1002/anie.201200020  0.64
2012 Fuchs G, Shema E, Vesterman R, Kotler E, Wolchinsky Z, Wilder S, Golomb L, Pribluda A, Zhang F, Haj-Yahya M, Feldmesser E, Brik A, Yu X, Hanna J, Aberdam D, et al. RNF20 and USP44 regulate stem cell differentiation by modulating H2B monoubiquitylation. Molecular Cell. 46: 662-73. PMID 22681888 DOI: 10.1016/j.molcel.2015.10.007  0.64
2012 Siman P, Brik A. Chemical and semisynthesis of posttranslationally modified proteins Organic and Biomolecular Chemistry. 10: 5684-5697. PMID 22527305 DOI: 10.1039/c2ob25149c  0.64
2012 Siman P, Karthikeyan SV, Brik A. Native chemical ligation at glutamine. Organic Letters. 14: 1520-3. PMID 22360701 DOI: 10.1021/ol300254y  0.64
2012 Ohayon S, Spasser L, Aharoni A, Brik A. Targeting deubiquitinases enabled by chemical synthesis of proteins. Journal of the American Chemical Society. 134: 3281-9. PMID 22279964 DOI: 10.1021/ja2116712  0.64
2012 Bavikar SN, Spasser L, Haj-Yahya M, Karthikeyan SV, Moyal T, Kumar KS, Brik A. Chemical synthesis of ubiquitinated peptides with varying lengths and types of ubiquitin chains to explore the activity of deubiquitinases. Angewandte Chemie (International Ed. in English). 51: 758-63. PMID 22131237 DOI: 10.1002/anie.201106430  0.64
2011 Castañeda CA, Spasser L, Bavikar SN, Brik A, Fushman D. Segmental isotopic labeling of ubiquitin chains to unravel monomer-specific molecular behavior. Angewandte Chemie (International Ed. in English). 50: 11210-4. PMID 21957015 DOI: 10.1002/anie.201104649  0.64
2011 Zeytuni N, Ozyamak E, Ben-Harush K, Davidov G, Levin M, Gat Y, Moyal T, Brik A, Komeili A, Zarivach R. Self-recognition mechanism of MamA, a magnetosome-associated TPR-containing protein, promotes complex assembly. Proceedings of the National Academy of Sciences of the United States of America. 108: E480-7. PMID 21784982 DOI: 10.1073/pnas.1103367108  0.64
2011 Roytman R, Adler-Abramovich L, Kumar KS, Kuan TC, Lin CC, Gazit E, Brik A. Exploring the self-assembly of glycopeptides using a diphenylalanine scaffold. Organic & Biomolecular Chemistry. 9: 5755-61. PMID 21720631 DOI: 10.1039/c1ob05071k  0.64
2011 Kumar KS, Bavikar SN, Spasser L, Moyal T, Ohayon S, Brik A. Total chemical synthesis of a 304 amino acid K48-linked tetraubiquitin protein. Angewandte Chemie (International Ed. in English). 50: 6137-41. PMID 21591043 DOI: 10.1002/anie.201101920  0.64
2011 Siman P, Blatt O, Moyal T, Danieli T, Lebendiker M, Lashuel HA, Friedler A, Brik A. Chemical synthesis and expression of the HIV-1 Rev protein. Chembiochem : a European Journal of Chemical Biology. 12: 1097-104. PMID 21488138 DOI: 10.1002/cbic.201100033  0.64
2011 Spasser L, Ajish Kumar KS, Brik A. Scope and limitation of side-chain assisted ligation Journal of Peptide Science. 17: 252-255. PMID 21391285 DOI: 10.1002/psc.1336  0.64
2011 Kumar KS, Spasser L, Ohayon S, Erlich LA, Brik A. Expeditious chemical synthesis of ubiquitinated peptides employing orthogonal protection and native chemical ligation. Bioconjugate Chemistry. 22: 137-43. PMID 21235224 DOI: 10.1021/bc1004735  0.64
2011 Hejjaoui M, Haj-Yahya M, Kumar KS, Brik A, Lashuel HA. Towards elucidation of the role of ubiquitination in the pathogenesis of Parkinson's disease with semisynthetic ubiquitinated α-synuclein. Angewandte Chemie (International Ed. in English). 50: 405-9. PMID 21154793 DOI: 10.1002/anie.201005546  0.64
2010 Kumar KSA, Brik A. Accessing posttranslationally modified proteins through thiol positioning Journal of Peptide Science. 16: 524-529. PMID 20862719 DOI: 10.1002/psc.1229  0.64
2010 Kumar KSA, Spasser L, Erlich LA, Bavikar SN, Brik A. Total chemical synthesis of di-ubiquitin chains Angewandte Chemie - International Edition. 49: 9126-9131. PMID 20815002 DOI: 10.1002/anie.201003763  0.64
2010 Haj-Yahya M, Ajish Kumar KS, Erlich LA, Brik A. Protecting group variations of delta-mercaptolysine useful in chemical ubiquitylation Biopolymers. 94: 504-510. PMID 20564006 DOI: 10.1002/bip.21384  0.64
2010 Erlich LA, Kumar KS, Haj-Yahya M, Dawson PE, Brik A. N-methylcysteine-mediated total chemical synthesis of ubiquitin thioester. Organic & Biomolecular Chemistry. 8: 2392-6. PMID 20448897 DOI: 10.1039/c000332h  0.64
2010 Harpaz Z, Siman P, Ajish Kumar KS, Brik A. Protein synthesis assisted by native chemical ligation at leucine Chembiochem. 11: 1232-1235+1158. PMID 20437446 DOI: 10.1002/cbic.201000168  0.64
2009 Ajish Kumar KS, Haj-Yahya M, Olschewski D, Lashuel HA, Brik A. Highly efficient and chemoselective peptide ubiquitylation. Angewandte Chemie (International Ed. in English). 48: 8090-4. PMID 19780082 DOI: 10.1002/anie.200902936  0.64
2009 Ajish Kumar KS, Harpaz Z, Haj-Yahya M, Brik A. Side-chain assisted ligation in protein synthesis Bioorganic and Medicinal Chemistry Letters. 19: 3870-3874. PMID 19376701 DOI: 10.1016/j.bmcl.2009.03.156  0.64
2008 Nepomniaschiy N, Grimminger V, Cohen A, DiGiovanni S, Lashuel HA, Brik A. Switch peptide via Staudinger reaction. Organic Letters. 10: 5243-6. PMID 18959426 DOI: 10.1021/ol802268e  0.64
2008 Giffin MJ, Heaslet H, Brik A, Lin YC, Cauvi G, Wong CH, McRee DE, Elder JH, Stout CD, Torbett BE. A copper(I)-catalyzed 1,2,3-triazole azide-alkyne click compound is a potent inhibitor of a multidrug-resistant HIV-1 protease variant. Journal of Medicinal Chemistry. 51: 6263-70. PMID 18823110 DOI: 10.1021/jm800149m  0.64
2008 Bennett CS, Dean SM, Payne RJ, Ficht S, Brik A, Wong CH. Sugar-assisted glycopeptide ligation with complex oligosaccharides: scope and limitations. Journal of the American Chemical Society. 130: 11945-52. PMID 18698778 DOI: 10.1021/ja8010513  0.64
2008 Lutsky MY, Nepomniaschiy N, Brik A. Peptide ligation via side-chain auxiliary Chemical Communications. 1229-1231. PMID 18309426 DOI: 10.1039/b718945a  0.64
2007 Payne RJ, Ficht S, Tang S, Brik A, Yang YY, Case DA, Wong CH. Extended sugar-assisted glycopeptide ligations: development, scope, and applications. Journal of the American Chemical Society. 129: 13527-36. PMID 17935327 DOI: 10.1021/ja073653p  0.64
2007 Ficht S, Payne RJ, Brik A, Wong CH. Second-generation sugar-assisted ligation: a method for the synthesis of cysteine-containing glycopeptides. Angewandte Chemie (International Ed. in English). 46: 5975-9. PMID 17607677 DOI: 10.1002/anie.200700546  0.64
2007 Yang YY, Ficht S, Brik A, Wong CH. Sugar-assisted ligation in glycoprotein synthesis Journal of the American Chemical Society. 129: 7690-7701. PMID 17523644 DOI: 10.1021/ja0708971  0.64
2007 Brik A, Wong CH. Sugar-assisted ligation for the synthesis of glycopeptides Chemistry - a European Journal. 13: 5670-5675. PMID 17508364 DOI: 10.1002/chem.200700330  0.64
2006 Brik A, Ficht S, Yang YY, Bennett CS, Wong CH. Sugar-assisted ligation of N-linked glycopeptides with broad sequence tolerance at the ligation junction. Journal of the American Chemical Society. 128: 15026-33. PMID 17105315 DOI: 10.1021/ja065601q  0.64
2006 Brik A, Ficht S, Wong CH. Strategies for the preparation of homogenous glycoproteins Current Opinion in Chemical Biology. 10: 638-644. PMID 17046315 DOI: 10.1016/j.cbpa.2006.10.003  0.64
2006 Lin YC, Brik A, de Parseval A, Tam K, Torbett BE, Wong CH, Elder JH. Altered gag polyprotein cleavage specificity of feline immunodeficiency virus/human immunodeficiency virus mutant proteases as demonstrated in a cell-based expression system. Journal of Virology. 80: 7832-43. PMID 16873240 DOI: 10.1128/JVI.00374-06  0.64
2006 Brik A, Wu CY, Wong CH. Microtiter plate based chemistry and in situ screening: A useful approach for rapid inhibitor discovery Organic and Biomolecular Chemistry. 4: 1446-1457. PMID 16604207 DOI: 10.1039/b600055j  0.64
2006 Liang FS, Brik A, Lin YC, Elder JH, Wong CH. Epoxide opening in water and screening in situ for rapid discovery of enzyme inhibitors in microtiter plates. Bioorganic & Medicinal Chemistry. 14: 1058-62. PMID 16275107 DOI: 10.1016/j.bmc.2005.09.026  0.64
2005 Wu CY, Brik A, Wang SK, Chen YH, Wong CH. Tetrabutylammonium fluoride-mediated rapid alkylation reaction in microtiter plates for the discovery of enzyme inhibitors in situ Chembiochem. 6: 2176-2180. PMID 16270365 DOI: 10.1002/cbic.200500295  0.64
2005 Brik A, Wu CY, Best MD, Wong CH. Tetrabutylammonium fluoride-assisted rapid N9-alkylation on purine ring: Application to combinatorial reactions in microtiter plates for the discovery of potent sulfotransferase inhibitors in situ Bioorganic and Medicinal Chemistry. 13: 4622-4626. PMID 15953729 DOI: 10.1016/j.bmc.2005.02.066  0.64
2005 Brik A, Alexandratos J, Lin YC, Elder JH, Olson AJ, Wlodawer A, Goodsell DS, Wong CH. 1,2,3-triazole as a peptide surrogate in the rapid synthesis of HIV-1 protease inhibitors. Chembiochem : a European Journal of Chemical Biology. 6: 1167-9. PMID 15934050 DOI: 10.1002/cbic.200500101  0.64
2004 Metanis N, Brik A, Dawson PE, Keinan E. Electrostatic interactions dominate the catalytic contribution of arg39 in 4-oxalocrotonate tautomerase. Journal of the American Chemical Society. 126: 12726-7. PMID 15469238 DOI: 10.1021/ja0463841  0.64
2004 Wu CY, Jan JT, Ma SH, Kuo CJ, Juan HF, Cheng YS, Hsu HH, Huang HC, Wu D, Brik A, Liang FS, Liu RS, Fang JM, Chen ST, Liang PH, et al. Small molecules targeting severe acute respiratory syndrome human coronavirus. Proceedings of the National Academy of Sciences of the United States of America. 101: 10012-7. PMID 15226499 DOI: 10.1073/pnas.0403596101  0.64
2004 Cheng TJ, Brik A, Wong CH, Kan CC. Model system for high-throughput screening of novel human immunodeficiency virus protease inhibitors in Escherichia coli Antimicrobial Agents and Chemotherapy. 48: 2437-2447. PMID 15215092 DOI: 10.1128/AAC.48.7.2437-2447.2004  0.64
2004 Best MD, Brik A, Chapman E, Lee LV, Cheng WC, Wong CH. Rapid discovery of potent sulfotransferase inhibitors by diversity-oriented reaction in microplates followed by in situ screening. Chembiochem : a European Journal of Chemical Biology. 5: 811-9. PMID 15174164 DOI: 10.1002/cbic.200300841  0.64
2003 Brik A, Muldoon J, Lin YC, Elder JH, Goodsell DS, Olson AJ, Fokin VV, Sharpless KB, Wong CH. Rapid diversity-oriented synthesis in microtiter plates for in situ screening of HIV protease inhibitors. Chembiochem : a European Journal of Chemical Biology. 4: 1246-8. PMID 14613121 DOI: 10.1002/cbic.200300724  0.64
2003 Mak CC, Brik A, Lerner DL, Elder JH, Morris GM, Olson AJ, Wong CH. Design and synthesis of broad-based mono- and bi- cyclic inhibitors of FIV and HIV proteases. Bioorganic & Medicinal Chemistry. 11: 2025-40. PMID 12670654 DOI: 10.1016/S0968-0896(03)00054-3  0.64
2002 Brik A, Dawson PE, Keinan E. The product of the natural reaction catalyzed by 4-oxalocrotonate tautomerase becomes an affinity label of its mutant. Bioorganic & Medicinal Chemistry. 10: 3891-7. PMID 12413840 DOI: 10.1016/S0968-0896(02)00385-1  0.64
2002 Brik A, D'Souza LJ, Keinan E, Grynszpan F, Dawson PE. Mutants of 4-oxalocrotonate tautomerase catalyze the decarboxylation of oxaloacetate through an imine mechanism. Chembiochem : a European Journal of Chemical Biology. 3: 845-51. PMID 12210985 DOI: 10.1002/1439-7633(20020902)3:9<845::AID-CBIC845>3.0.CO;2-2  0.64
2002 Brik A, Lin YC, Elder J, Wong CH. A quick diversity-oriented amide-forming reaction to optimize p-subsite residues of HIV protease inhibitors Chemistry and Biology. 9: 891-896. PMID 12204688 DOI: 10.1016/S1074-5521(02)00184-9  0.64
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