Raymond C. Stevens, Ph.D. - Publications

Affiliations: 
1991-1999 Chemistry University of California, Berkeley, Berkeley, CA 
 1999-2014 Molecular Biology Scripps Research Institute, La Jolla, La Jolla, CA, United States 
 2014- Biological Sciences and Chemistry University of Southern California, Los Angeles, CA, United States 
Area:
Structural Biology, Receptors
Website:
http://chem.usc.edu/faculty/Stevens.html

320 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Li JC, Nastertorabi F, Xuan W, Han GW, Stevens RC, Schultz PG. A Single Reactive Noncanonical Amino Acid Is Able to Dramatically Stabilize Protein Structure. Acs Chemical Biology. PMID 31181898 DOI: 10.1021/acschembio.9b00002  1
2019 Xue D, Ye L, Zheng J, Wu Y, Zhang X, Xu Y, Li T, Stevens RC, Xu F, Zhuang M, Zhao S, Zhao F, Tao H. The structure-based traceless specific fluorescence labeling of the smoothened receptor. Organic & Biomolecular Chemistry. PMID 31180094 DOI: 10.1039/c9ob00654k  1
2019 Lu Y, Qin S, Zhang B, Dai A, Cai X, Ma M, Gao ZG, Yang D, Stevens RC, Jacobson KA, Wang MW, Shui W. Accelerating the Throughput of Affinity Mass Spectrometry-Based Ligand Screening towards a G Protein-Coupled Receptor. Analytical Chemistry. PMID 31094506 DOI: 10.1021/acs.analchem.9b00477  1
2019 Stauch B, Johansson LC, McCorvy JD, Patel N, Han GW, Huang XP, Gati C, Batyuk A, Slocum ST, Ishchenko A, Brehm W, White TA, Michaelian N, Madsen C, Zhu L, ... ... Stevens RC, et al. Publisher Correction: Structural basis of ligand recognition at the human MT melatonin receptor. Nature. PMID 31048811 DOI: 10.1038/s41586-019-1209-0  0.92
2019 Gutierrez MG, Deyell J, White KL, Dalle Ore LC, Cherezov V, Stevens RC, Malmstadt N. The lipid phase preference of the adenosine A receptor depends on its ligand binding state. Chemical Communications (Cambridge, England). PMID 31038495 DOI: 10.1039/c8cc10130b  0.92
2019 Stauch B, Johansson LC, McCorvy JD, Patel N, Han GW, Huang XP, Gati C, Batyuk A, Slocum ST, Ishchenko A, Brehm W, White TA, Michaelian N, Madsen C, Zhu L, ... ... Stevens RC, et al. Structural basis of ligand recognition at the human MT melatonin receptor. Nature. PMID 31019306 DOI: 10.1038/s41586-019-1141-3  0.92
2019 Johansson LC, Stauch B, McCorvy JD, Han GW, Patel N, Huang XP, Batyuk A, Gati C, Slocum ST, Li C, Grandner JM, Hao S, Olsen RHJ, Tribo AR, Zaare S, ... ... Stevens RC, et al. XFEL structures of the human MT melatonin receptor reveal the basis of subtype selectivity. Nature. PMID 31019305 DOI: 10.1038/s41586-019-1144-0  0.92
2019 Zhao S, Wu B, Stevens RC. Advancing Chemokine GPCR Structure Based Drug Discovery. Structure (London, England : 1993). 27: 405-408. PMID 30840872 DOI: 10.1016/j.str.2019.02.004  1
2019 Xu M, Singla J, Tocheva EI, Chang YW, Stevens RC, Jensen GJ, Alber F. De Novo Structural Pattern Mining in Cellular Electron Cryotomograms. Structure (London, England : 1993). PMID 30744995 DOI: 10.1016/j.str.2019.01.005  0.76
2019 Chen S, Lu M, Liu D, Yang L, Yi C, Ma L, Zhang H, Liu Q, Frimurer TM, Wang MW, Schwartz TW, Stevens RC, Wu B, Wüthrich K, Zhao Q. Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography. Nature Communications. 10: 638. PMID 30733446 DOI: 10.1038/s41467-019-08568-5  1
2019 Munk C, Mutt E, Isberg V, Nikolajsen LF, Bibbe JM, Flock T, Hanson MA, Stevens RC, Deupi X, Gloriam DE. An online resource for GPCR structure determination and analysis. Nature Methods. PMID 30664776 DOI: 10.1038/s41592-018-0302-x  1
2018 Li X, Hua T, Vemuri K, Ho JH, Wu Y, Wu L, Popov P, Benchama O, Zvonok N, Locke K, Qu L, Han GW, Iyer MR, Cinar R, Coffey NJ, ... ... Stevens RC, et al. Crystal Structure of the Human Cannabinoid Receptor CB2. Cell. PMID 30639103 DOI: 10.1016/j.cell.2018.12.011  1
2018 Audet M, White KL, Breton B, Zarzycka B, Han GW, Lu Y, Gati C, Batyuk A, Popov P, Velasquez J, Manahan D, Hu H, Weierstall U, Liu W, Shui W, ... ... Stevens RC, et al. Publisher Correction: Crystal structure of misoprostol bound to the labor inducer prostaglandin E receptor. Nature Chemical Biology. PMID 30573766 DOI: 10.1038/s41589-018-0214-1  1
2018 Dai Z, Zhang XN, Nasertorabi F, Cheng Q, Pei H, Louie SG, Stevens RC, Zhang Y. Facile chemoenzymatic synthesis of a novel stable mimic of NAD. Chemical Science. 9: 8337-8342. PMID 30568770 DOI: 10.1039/c8sc03899f  0.8
2018 Audet M, White KL, Breton B, Zarzycka B, Han GW, Lu Y, Gati C, Batyuk A, Popov P, Velasquez J, Manahan D, Hu H, Weierstall U, Liu W, Shui W, ... ... Stevens RC, et al. Crystal structure of misoprostol bound to the labor inducer prostaglandin E receptor. Nature Chemical Biology. PMID 30510194 DOI: 10.1038/s41589-018-0160-y  1
2018 Sušac L, Eddy MT, Didenko T, Stevens RC, Wüthrich K. A adenosine receptor functional states characterized by F-NMR. Proceedings of the National Academy of Sciences of the United States of America. PMID 30463958 DOI: 10.1073/pnas.1813649115  0.84
2018 Audet M, Stevens RC. Emerging Structural Biology of Lipid G-Protein Coupled Receptors. Protein Science : a Publication of the Protein Society. PMID 30239054 DOI: 10.1002/pro.3509  0.96
2018 Yang S, Wu Y, Xu TH, de Waal PW, He Y, Pu M, Chen Y, DeBruine ZJ, Zhang B, Zaidi SA, Popov P, Guo Y, Han GW, Lu Y, Suino-Powell K, ... ... Stevens RC, et al. Crystal structure of the Frizzled 4 receptor in a ligand-free state. Nature. PMID 30135577 DOI: 10.1038/s41586-018-0447-x  1
2018 Levy HL, Sarkissian CN, Stevens RC, Scriver CR. Phenylalanine ammonia lyase (PAL): From discovery to enzyme substitution therapy for phenylketonuria. Molecular Genetics and Metabolism. PMID 29941359 DOI: 10.1016/j.ymgme.2018.06.002  0.36
2018 Popov P, Peng Y, Shen L, Stevens RC, Cherezov V, Liu ZJ, Katritch V. Computational design of thermostabilizing point mutations for G protein-coupled receptors. Elife. 7. PMID 29927385 DOI: 10.7554/eLife.34729  0.92
2018 Eddy MT, Gao ZG, Mannes P, Patel N, Jacobson KA, Katritch V, Stevens RC, Wüthrich K. Extrinsic Tryptophans as NMR Probes of Allosteric Coupling in Membrane Proteins: Application to the A2A Adenosine Receptor. Journal of the American Chemical Society. PMID 29874058 DOI: 10.1021/jacs.8b03805  1
2018 Cao C, Tan Q, Xu C, He L, Yang L, Zhou Y, Zhou Y, Qiao A, Lu M, Yi C, Han GW, Wang X, Li X, Yang H, Rao Z, ... ... Stevens RC, et al. Structural basis for signal recognition and transduction by platelet-activating-factor receptor. Nature Structural & Molecular Biology. PMID 29808000 DOI: 10.1038/s41594-018-0068-y  1
2018 Liu X, Gao ZG, Wu Y, Stevens RC, Jacobson KA, Zhao S. Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y and P2Y receptors. Scientific Reports. 8: 8084. PMID 29795391 DOI: 10.1038/s41598-018-26577-0  1
2018 Qin S, Meng M, Yang D, Bai W, Lu Y, Peng Y, Song G, Wu Y, Zhou Q, Zhao S, Huang X, McCorvy JD, Cai X, Dai A, Roth BL, ... ... Stevens RC, et al. High-throughput identification of G protein-coupled receptor modulators through affinity mass spectrometry screening. Chemical Science. 9: 3192-3199. PMID 29732102 DOI: 10.1039/c7sc04698g  1
2018 Yang Z, Han S, Keller M, Kaiser A, Bender BJ, Bosse M, Burkert K, Kögler LM, Wifling D, Bernhardt G, Plank N, Littmann T, Schmidt P, Yi C, Li B, ... ... Stevens RC, et al. Structural basis of ligand binding modes at the neuropeptide Y Y receptor. Nature. PMID 29670288 DOI: 10.1038/s41586-018-0046-x  1
2018 Peng Y, Zhao S, Wu Y, Cao H, Xu Y, Liu X, Shui W, Cheng J, Zhao S, Shen L, Ma J, Quinn RJ, Stevens RC, Zhong G, Liu ZJ. Identification of natural products as novel ligands for the human 5-HTreceptor. Biophysics Reports. 4: 50-61. PMID 29577069 DOI: 10.1007/s41048-018-0047-1  1
2018 Vass M, Kooistra AJ, Yang D, Stevens RC, Wang MW, de Graaf C. Chemical Diversity in the G Protein-Coupled Receptor Superfamily. Trends in Pharmacological Sciences. PMID 29576399 DOI: 10.1016/j.tips.2018.02.004  0.88
2018 Singla J, McClary KM, White KL, Alber F, Sali A, Stevens RC. Opportunities and Challenges in Building a Spatiotemporal Multi-scale Model of the Human Pancreatic β Cell. Cell. 173: 11-19. PMID 29570991 DOI: 10.1016/j.cell.2018.03.014  0.8
2018 Peng Y, McCorvy JD, Harpsøe K, Lansu K, Yuan S, Popov P, Qu L, Pu M, Che T, Nikolajsen LF, Huang XP, Wu Y, Shen L, Bjørn-Yoshimoto WE, Ding K, ... ... Stevens RC, et al. 5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology. Cell. PMID 29398112 DOI: 10.1016/j.cell.2018.01.001  1
2018 White KL, Eddy MT, Gao ZG, Han GW, Lian T, Deary A, Patel N, Jacobson KA, Katritch V, Stevens RC. Structural Connection between Activation Microswitch and Allosteric Sodium Site in GPCR Signaling. Structure (London, England : 1993). PMID 29395784 DOI: 10.1016/j.str.2017.12.013  1
2018 Che T, Majumdar S, Zaidi SA, Ondachi P, McCorvy JD, Wang S, Mosier PD, Uprety R, Vardy E, Krumm BE, Han GW, Lee MY, Pardon E, Steyaert J, Huang XP, ... ... Stevens RC, et al. Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor. Cell. PMID 29307491 DOI: 10.1016/j.cell.2017.12.011  0.92
2018 Zhang H, Qiao A, Yang L, Van Eps N, Frederiksen KS, Yang D, Dai A, Cai X, Zhang H, Yi C, Cao C, He L, Yang H, Lau J, Ernst OP, ... ... Stevens RC, et al. Structure of the glucagon receptor in complex with a glucagon analogue. Nature. 553: 106-110. PMID 29300013 DOI: 10.1038/nature25153  1
2017 Ye L, Ding K, Zhao F, Liu X, Wu Y, Liu Y, Xue D, Zhou F, Zhang X, Stevens RC, Xu F, Zhao S, Tao H. A structurally guided dissection-then-evolution strategy for ligand optimization of smoothened receptor. Medchemcomm. 8: 1332-1336. PMID 30108845 DOI: 10.1039/c7md00104e  1
2017 Roach JJ, Sasano Y, Schmid CL, Zaidi S, Katritch V, Stevens RC, Bohn LM, Shenvi RA. Dynamic Strategic Bond Analysis Yields a Ten-Step Synthesis of 20-nor-Salvinorin A, a Potent κ-OR Agonist. Acs Central Science. 3: 1329-1336. PMID 29296674 DOI: 10.1021/acscentsci.7b00488  0.84
2017 Eddy MT, Lee MY, Gao ZG, White KL, Didenko T, Horst R, Audet M, Stanczak P, McClary KM, Han GW, Jacobson KA, Stevens RC, Wüthrich K. Allosteric Coupling of Drug Binding and Intracellular Signaling in the A2A Adenosine Receptor. Cell. PMID 29290469 DOI: 10.1016/j.cell.2017.12.004  1
2017 de Graaf C, Song G, Cao C, Zhao Q, Wang MW, Wu B, Stevens RC. Extending the Structural View of Class B GPCRs. Trends in Biochemical Sciences. PMID 29132948 DOI: 10.1016/j.tibs.2017.10.003  1
2017 Zhou XE, He Y, de Waal PW, Gao X, Kang Y, Van Eps N, Yin Y, Pal K, Goswami D, White TA, Barty A, Latorraca NR, Chapman HN, Hubbell WL, Dror RO, ... Stevens RC, et al. Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors. Cell. 170: 457-469.e13. PMID 28753425 DOI: 10.1016/j.cell.2017.07.002  0.92
2017 Wacker D, Stevens RC, Roth BL. How Ligands Illuminate GPCR Molecular Pharmacology. Cell. 170: 414-427. PMID 28753422 DOI: 10.1016/j.cell.2017.07.009  0.84
2017 Ishchenko A, Wacker D, Kapoor M, Zhang A, Han GW, Basu S, Patel N, Messerschmidt M, Weierstall U, Liu W, Katritch V, Roth BL, Stevens RC, Cherezov V. Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody. Proceedings of the National Academy of Sciences of the United States of America. PMID 28716900 DOI: 10.1073/pnas.1700891114  0.92
2017 Wu F, Song G, de Graaf C, Stevens RC. Structure and function of peptide-binding G protein-coupled receptors. Journal of Molecular Biology. PMID 28705763 DOI: 10.1016/j.jmb.2017.06.022  0.68
2017 Hua T, Vemuri K, Nikas SP, Laprairie RB, Wu Y, Qu L, Pu M, Korde A, Jiang S, Ho JH, Han GW, Ding K, Li X, Liu H, Hanson MA, ... ... Stevens RC, et al. Crystal structures of agonist-bound human cannabinoid receptor CB1. Nature. PMID 28678776 DOI: 10.1038/nature23272  1
2017 Zheng Y, Han GW, Abagyan R, Wu B, Stevens RC, Cherezov V, Kufareva I, Handel TM. Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV. Immunity. 46: 1005-1017.e5. PMID 28636951 DOI: 10.1016/j.immuni.2017.05.002  1
2017 Ma Y, Yue Y, Ma Y, Zhang Q, Zhou Q, Song Y, Shen Y, Li X, Ma X, Li C, Hanson MA, Han GW, Sickmier EA, Swaminath G, Zhao S, ... Stevens RC, et al. Structural Basis for Apelin Control of the Human Apelin Receptor. Structure (London, England : 1993). PMID 28528775 DOI: 10.1016/j.str.2017.04.008  1
2017 Zhang H, Qiao A, Yang D, Yang L, Dai A, de Graaf C, Reedtz-Runge S, Dharmarajan V, Zhang H, Han GW, Grant TD, Sierra RG, Weierstall U, Nelson G, Liu W, ... ... Stevens RC, et al. Structure of the full-length glucagon class B G-protein-coupled receptor. Nature. PMID 28514451 DOI: 10.1038/nature22363  1
2017 Song G, Yang D, Wang Y, de Graaf C, Zhou Q, Jiang S, Liu K, Cai X, Dai A, Lin G, Liu D, Wu F, Wu Y, Zhao S, Ye L, ... ... Stevens RC, et al. Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators. Nature. PMID 28514449 DOI: 10.1038/nature22378  1
2017 Zhang X, Zhao F, Wu Y, Yang J, Han GW, Zhao S, Ishchenko A, Ye L, Lin X, Ding K, Dharmarajan V, Griffin PR, Gati C, Nelson G, Hunter MS, ... ... Stevens RC, et al. Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand. Nature Communications. 8: 15383. PMID 28513578 DOI: 10.1038/ncomms15383  1
2017 Koh M, Nasertorabi F, Han GW, Stevens RC, Schultz PG. Generation of an Orthogonal Protein-Protein Interface with a Noncanonical Amino Acid. Journal of the American Chemical Society. PMID 28413876 DOI: 10.1021/jacs.7b02273  1
2017 Zhang H, Han GW, Batyuk A, Ishchenko A, White KL, Patel N, Sadybekov A, Zamlynny B, Rudd MT, Hollenstein K, Tolstikova A, White TA, Hunter MS, Weierstall U, Liu W, ... ... Stevens RC, et al. Structural basis for selectivity and diversity in angiotensin II receptors. Nature. PMID 28379944 DOI: 10.1038/nature22035  0.92
2017 Zheng Z, Huang XP, Mangano TJ, Zou R, Chen X, Zaidi S, Roth BL, Stevens RC, Katritch V. Structure based discovery of new antagonist and biased agonist chemotypes for the Kappa Opioid Receptor. Journal of Medicinal Chemistry. PMID 28339199 DOI: 10.1021/acs.jmedchem.7b00109  0.84
2016 Zheng Y, Qin L, Zacarías NV, de Vries H, Han GW, Gustavsson M, Dabros M, Zhao C, Cherney RJ, Carter P, Stamos D, Abagyan R, Cherezov V, Stevens RC, IJzerman AP, et al. Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists. Nature. PMID 27926736 DOI: 10.1038/nature20605  0.92
2016 Eddy MT, Didenko T, Stevens RC, Wüthrich K. β2-Adrenergic Receptor Conformational Response to Fusion Protein in the Third Intracellular Loop. Structure (London, England : 1993). 24: 2190-2197. PMID 27839952 DOI: 10.1016/j.str.2016.09.015  0.84
2016 Hua T, Vemuri K, Pu M, Qu L, Han GW, Wu Y, Zhao S, Shui W, Li S, Korde A, Laprairie RB, Stahl EL, Ho JH, Zvonok N, Zhou H, ... ... Stevens RC, et al. Crystal Structure of the Human Cannabinoid Receptor CB1. Cell. 167: 750-762.e14. PMID 27768894 DOI: 10.1016/j.cell.2016.10.004  1
2016 Batyuk A, Galli L, Ishchenko A, Han GW, Gati C, Popov PA, Lee MY, Stauch B, White TA, Barty A, Aquila A, Hunter MS, Liang M, Boutet S, Pu M, ... ... Stevens RC, et al. Native phasing of x-ray free-electron laser data for a G protein-coupled receptor. Science Advances. 2: e1600292. PMID 27679816 DOI: 10.1126/sciadv.1600292  0.92
2016 Yuan S, Chan HC, Vogel H, Filipek S, Stevens RC, Palczewski K. The Molecular Mechanism of P2Y1 Receptor Activation. Angewandte Chemie (International Ed. in English). PMID 27460867 DOI: 10.1002/anie.201605147  1
2016 Lv X, Liu J, Shi Q, Tan Q, Wu D, Skinner JJ, Walker AL, Zhao L, Gu X, Chen N, Xue L, Si P, Zhang L, Wang Z, Katritch V, ... ... Stevens RC, et al. In vitro expression and analysis of the 826 human G protein-coupled receptors. Protein & Cell. PMID 27085723 DOI: 10.1007/s13238-016-0263-8  0.8
2016 Zhou XE, Gao X, Barty A, Kang Y, He Y, Liu W, Ishchenko A, White TA, Yefanov O, Han GW, Xu Q, de Waal PW, Suino-Powell KM, Boutet S, Williams GJ, ... ... Stevens RC, et al. X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex. Scientific Data. 3: 160021. PMID 27070998 DOI: 10.1038/sdata.2016.21  0.8
2016 Yang D, de Graaf C, Yang L, Song G, Dai A, Cai X, Feng Y, Reedtz-Runge S, Hanson MA, Yang H, Jiang H, Stevens RC, Wang MW. Structural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor. The Journal of Biological Chemistry. PMID 27059958 DOI: 10.1074/jbc.M116.721977  1
2016 Bennett BC, Purdy MD, Baker KA, Acharya C, McIntire WE, Stevens RC, Zhang Q, Harris AL, Abagyan R, Yeager M. An electrostatic mechanism for Ca(2+)-mediated regulation of gap junction channels. Nature Communications. 7: 8770. PMID 26753910 DOI: 10.1038/ncomms9770  0.8
2015 Lamichhane R, Liu JJ, Pljevaljcic G, White KL, van der Schans E, Katritch V, Stevens RC, Wüthrich K, Millar DP. Single-molecule view of basal activity and activation mechanisms of the G protein-coupled receptor β2AR. Proceedings of the National Academy of Sciences of the United States of America. 112: 14254-9. PMID 26578769 DOI: 10.1073/pnas.1519626112  0.84
2015 Sušac L, O'Connor C, Stevens RC, Wüthrich K. In-Membrane Chemical Modification (IMCM) for Site-Specific Chromophore Labeling of GPCRs. Angewandte Chemie (International Ed. in English). 54: 15246-9. PMID 26545333 DOI: 10.1002/anie.201508506  0.84
2015 Miller RL, Thompson AA, Trapella C, Guerrini R, Malfacini D, Patel N, Han GW, Cherezov V, Caló G, Katritch V, Stevens RC. The Importance of Ligand-Receptor Conformational Pairs in Stabilization: Spotlight on the N/OFQ G Protein-Coupled Receptor. Structure (London, England : 1993). PMID 26526853 DOI: 10.1016/j.str.2015.07.024  1
2015 Zhang H, Unal H, Desnoyer R, Han GW, Patel N, Katritch V, Karnik SS, Cherezov V, Stevens RC. Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor. The Journal of Biological Chemistry. PMID 26420482 DOI: 10.1074/jbc.M115.689000  1
2015 O'Connor C, White KL, Doncescu N, Didenko T, Roth BL, Czaplicki G, Stevens RC, Wüthrich K, Milon A. NMR structure and dynamics of the agonist dynorphin peptide bound to the human kappa opioid receptor. Proceedings of the National Academy of Sciences of the United States of America. 112: 11852-7. PMID 26372966 DOI: 10.1073/pnas.1510117112  0.84
2015 Kiselev E, Balasubramanian R, Uliassi E, Brown KA, Trujillo K, Katritch V, Hammes E, Stevens RC, Harden TK, Jacobson KA. Design, synthesis, pharmacological characterization of a fluorescent agonist of the P2Y14 receptor. Bioorganic & Medicinal Chemistry Letters. 25: 4733-9. PMID 26303895 DOI: 10.1016/j.bmcl.2015.08.021  0.8
2015 Yang L, Yang D, de Graaf C, Moeller A, West GM, Dharmarajan V, Wang C, Siu FY, Song G, Reedtz-Runge S, Pascal BD, Wu B, Potter CS, Zhou H, Griffin PR, ... ... Stevens RC, et al. Conformational states of the full-length glucagon receptor. Nature Communications. 6: 7859. PMID 26227798 DOI: 10.1038/ncomms8859  1
2015 Kang Y, Zhou XE, Gao X, He Y, Liu W, Ishchenko A, Barty A, White TA, Yefanov O, Han GW, Xu Q, de Waal PW, Ke J, Tan MH, Zhang C, ... ... Stevens RC, et al. Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser. Nature. PMID 26200343 DOI: 10.1038/nature14656  1
2015 Paoletta S, Sabbadin D, von Kügelgen I, Hinz S, Katritch V, Hoffmann K, Abdelrahman A, Straßburger J, Baqi Y, Zhao Q, Stevens RC, Moro S, Müller CE, Jacobson KA. Modeling ligand recognition at the P2Y12 receptor in light of X-ray structural information. Journal of Computer-Aided Molecular Design. PMID 26194851 DOI: 10.1007/s10822-015-9858-z  0.8
2015 Vardy E, Sassano MF, Rennekamp AJ, Kroeze WK, Mosier PD, Westkaemper RB, Stevens CW, Katritch V, Stevens RC, Peterson RT, Roth BL. Single Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides. Chemistry & Biology. 22: 764-75. PMID 26091169 DOI: 10.1016/j.chembiol.2015.05.012  1
2015 Chrencik JE, Roth CB, Terakado M, Kurata H, Omi R, Kihara Y, Warshaviak D, Nakade S, Asmar-Rovira G, Mileni M, Mizuno H, Griffith MT, Rodgers C, Han GW, Velasquez J, ... ... Stevens RC, et al. Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1. Cell. 161: 1633-43. PMID 26091040 DOI: 10.1016/j.cell.2015.06.002  1
2015 Xiao H, Nasertorabi F, Choi SH, Han GW, Reed SA, Stevens RC, Schultz PG. Exploring the potential impact of an expanded genetic code on protein function. Proceedings of the National Academy of Sciences of the United States of America. 112: 6961-6. PMID 26038548 DOI: 10.1073/pnas.1507741112  1
2015 Zhang H, Unal H, Gati C, Han GW, Liu W, Zatsepin NA, James D, Wang D, Nelson G, Weierstall U, Sawaya MR, Xu Q, Messerschmidt M, Williams GJ, Boutet S, ... ... Stevens RC, et al. Structure of the Angiotensin receptor revealed by serial femtosecond crystallography. Cell. 161: 833-44. PMID 25913193 DOI: 10.1016/j.cell.2015.04.011  1
2015 Jacobson KA, Paoletta S, Katritch V, Wu B, Gao ZG, Zhao Q, Stevens RC, Kiselev E. Nucleotides Acting at P2Y Receptors: Connecting Structure and Function. Molecular Pharmacology. 88: 220-30. PMID 25837834 DOI: 10.1124/mol.114.095711  0.8
2015 Zhang D, Gao ZG, Zhang K, Kiselev E, Crane S, Wang J, Paoletta S, Yi C, Ma L, Zhang W, Han GW, Liu H, Cherezov V, Katritch V, Jiang H, ... Stevens RC, et al. Two disparate ligand-binding sites in the human P2Y1 receptor. Nature. 520: 317-21. PMID 25822790 DOI: 10.1038/nature14287  1
2015 Pearson AD, Mills JH, Song Y, Nasertorabi F, Han GW, Baker D, Stevens RC, Schultz PG. Transition states. Trapping a transition state in a computationally designed protein bottle. Science (New York, N.Y.). 347: 863-7. PMID 25700516 DOI: 10.1126/science.aaa2424  1
2015 Fenalti G, Zatsepin NA, Betti C, Giguere P, Han GW, Ishchenko A, Liu W, Guillemyn K, Zhang H, James D, Wang D, Weierstall U, Spence JC, Boutet S, Messerschmidt M, ... ... Stevens RC, et al. Structural basis for bifunctional peptide recognition at human δ-opioid receptor. Nature Structural & Molecular Biology. 22: 265-8. PMID 25686086 DOI: 10.1038/nsmb.2965  1
2015 Qin L, Kufareva I, Holden LG, Wang C, Zheng Y, Zhao C, Fenalti G, Wu H, Han GW, Cherezov V, Abagyan R, Stevens RC, Handel TM. Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine. Science (New York, N.Y.). 347: 1117-22. PMID 25612609 DOI: 10.1126/science.1261064  1
2015 Zhang X, Stevens RC, Xu F. The importance of ligands for G protein-coupled receptor stability. Trends in Biochemical Sciences. 40: 79-87. PMID 25601764 DOI: 10.1016/j.tibs.2014.12.005  1
2015 Isberg V, de Graaf C, Bortolato A, Cherezov V, Katritch V, Marshall FH, Mordalski S, Pin JP, Stevens RC, Vriend G, Gloriam DE. Generic GPCR residue numbers - aligning topology maps while minding the gaps. Trends in Pharmacological Sciences. 36: 22-31. PMID 25541108 DOI: 10.1016/j.tips.2014.11.001  0.8
2015 Massink A, Gutiérrez-de-Terán H, Lenselink EB, Ortiz Zacarías NV, Xia L, Heitman LH, Katritch V, Stevens RC, IJzerman AP. Sodium ion binding pocket mutations and adenosine A2A receptor function. Molecular Pharmacology. 87: 305-13. PMID 25473121 DOI: 10.1124/mol.114.095737  0.8
2014 Kiselev E, Barrett MO, Katritch V, Paoletta S, Weitzer CD, Brown KA, Hammes E, Yin AL, Zhao Q, Stevens RC, Harden TK, Jacobson KA. Exploring a 2-naphthoic acid template for the structure-based design of P2Y14 receptor antagonist molecular probes. Acs Chemical Biology. 9: 2833-42. PMID 25299434 DOI: 10.1021/cb500614p  1
2014 Goren MA, Morizumi T, Menon I, Joseph JS, Dittman JS, Cherezov V, Stevens RC, Ernst OP, Menon AK. Constitutive phospholipid scramblase activity of a G protein-coupled receptor. Nature Communications. 5: 5115. PMID 25296113 DOI: 10.1038/ncomms6115  1
2014 Kufareva I, Katritch V, Stevens RC, Abagyan R. Advances in GPCR modeling evaluated by the GPCR Dock 2013 assessment: meeting new challenges. Structure (London, England : 1993). 22: 1120-39. PMID 25066135 DOI: 10.1016/j.str.2014.06.012  0.4
2014 Wang C, Wu H, Evron T, Vardy E, Han GW, Huang XP, Hufeisen SJ, Mangano TJ, Urban DJ, Katritch V, Cherezov V, Caron MG, Roth BL, Stevens RC. Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs. Nature Communications. 5: 4355. PMID 25008467 DOI: 10.1038/ncomms5355  1
2014 Zhang J, Zhang K, Gao ZG, Paoletta S, Zhang D, Han GW, Li T, Ma L, Zhang W, Müller CE, Yang H, Jiang H, Cherezov V, Katritch V, Jacobson KA, ... Stevens RC, et al. Agonist-bound structure of the human P2Y12 receptor. Nature. 509: 119-22. PMID 24784220 DOI: 10.1038/nature13288  1
2014 Katritch V, Fenalti G, Abola EE, Roth BL, Cherezov V, Stevens RC. Allosteric sodium in class A GPCR signaling. Trends in Biochemical Sciences. 39: 233-44. PMID 24767681 DOI: 10.1016/j.tibs.2014.03.002  1
2014 Zhang K, Zhang J, Gao ZG, Zhang D, Zhu L, Han GW, Moss SM, Paoletta S, Kiselev E, Lu W, Fenalti G, Zhang W, Müller CE, Yang H, Jiang H, ... ... Stevens RC, et al. Structure of the human P2Y12 receptor in complex with an antithrombotic drug. Nature. 509: 115-8. PMID 24670650 DOI: 10.1038/nature13083  1
2014 Wu H, Wang C, Gregory KJ, Han GW, Cho HP, Xia Y, Niswender CM, Katritch V, Meiler J, Cherezov V, Conn PJ, Stevens RC. Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator. Science (New York, N.Y.). 344: 58-64. PMID 24603153 DOI: 10.1126/science.1249489  1
2014 Weierstall U, James D, Wang C, White TA, Wang D, Liu W, Spence JC, Bruce Doak R, Nelson G, Fromme P, Fromme R, Grotjohann I, Kupitz C, Zatsepin NA, Liu H, ... ... Stevens RC, et al. Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography. Nature Communications. 5: 3309. PMID 24525480 DOI: 10.1038/ncomms4309  1
2014 Fenalti G, Giguere PM, Katritch V, Huang XP, Thompson AA, Cherezov V, Roth BL, Stevens RC. Molecular control of δ-opioid receptor signalling. Nature. 506: 191-6. PMID 24413399 DOI: 10.1038/nature12944  1
2014 Hollenstein K, de Graaf C, Bortolato A, Wang MW, Marshall FH, Stevens RC. Insights into the structure of class B GPCRs. Trends in Pharmacological Sciences. 35: 12-22. PMID 24359917 DOI: 10.1016/j.tips.2013.11.001  1
2014 Skjevik AA, Mileni M, Baumann A, Halskau O, Teigen K, Stevens RC, Martinez A. The N-terminal sequence of tyrosine hydroxylase is a conformationally versatile motif that binds 14-3-3 proteins and membranes. Journal of Molecular Biology. 426: 150-68. PMID 24055376 DOI: 10.1016/j.jmb.2013.09.012  1
2013 Liu W, Wacker D, Gati C, Han GW, James D, Wang D, Nelson G, Weierstall U, Katritch V, Barty A, Zatsepin NA, Li D, Messerschmidt M, Boutet S, Williams GJ, ... ... Stevens RC, et al. Serial femtosecond crystallography of G protein-coupled receptors. Science (New York, N.Y.). 342: 1521-4. PMID 24357322 DOI: 10.1126/science.1244142  1
2013 Coin I, Katritch V, Sun T, Xiang Z, Siu FY, Beyermann M, Stevens RC, Wang L. Genetically encoded chemical probes in cells reveal the binding path of urocortin-I to CRF class B GPCR. Cell. 155: 1258-69. PMID 24290358 DOI: 10.1016/j.cell.2013.11.008  1
2013 Gutiérrez-de-Terán H, Massink A, Rodríguez D, Liu W, Han GW, Joseph JS, Katritch I, Heitman LH, Xia L, Ijzerman AP, Cherezov V, Katritch V, Stevens RC. The role of a sodium ion binding site in the allosteric modulation of the A(2A) adenosine G protein-coupled receptor. Structure (London, England : 1993). 21: 2175-85. PMID 24210756 DOI: 10.1016/j.str.2013.09.020  1
2013 Vardy E, Mosier PD, Frankowski KJ, Wu H, Katritch V, Westkaemper RB, Aubé J, Stevens RC, Roth BL. Chemotype-selective modes of action of κ-opioid receptor agonists. The Journal of Biological Chemistry. 288: 34470-83. PMID 24121503 DOI: 10.1074/jbc.M113.515668  1
2013 Tan Q, Zhu Y, Li J, Chen Z, Han GW, Kufareva I, Li T, Ma L, Fenalti G, Li J, Zhang W, Xie X, Yang H, Jiang H, Cherezov V, ... ... Stevens RC, et al. Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex. Science (New York, N.Y.). 341: 1387-90. PMID 24030490 DOI: 10.1126/science.1241475  1
2013 Lane JR, Chubukov P, Liu W, Canals M, Cherezov V, Abagyan R, Stevens RC, Katritch V. Structure-based ligand discovery targeting orthosteric and allosteric pockets of dopamine receptors. Molecular Pharmacology. 84: 794-807. PMID 24021214 DOI: 10.1124/mol.113.088054  0.92
2013 Horst R, Liu JJ, Stevens RC, Wüthrich K. β₂-adrenergic receptor activation by agonists studied with ¹⁹F NMR spectroscopy. Angewandte Chemie (International Ed. in English). 52: 10762-5. PMID 23956158 DOI: 10.1002/anie.201305286  0.84
2013 Didenko T, Liu JJ, Horst R, Stevens RC, Wüthrich K. Fluorine-19 NMR of integral membrane proteins illustrated with studies of GPCRs. Current Opinion in Structural Biology. 23: 740-747. PMID 23932201 DOI: 10.1016/j.sbi.2013.07.011  0.84
2013 Shi Y, Stevens RC. Asia growth in membrane protein structure. Current Opinion in Structural Biology. 23: 481-2. PMID 23890727 DOI: 10.1016/j.sbi.2013.07.002  0.84
2013 Siu FY, He M, de Graaf C, Han GW, Yang D, Zhang Z, Zhou C, Xu Q, Wacker D, Joseph JS, Liu W, Lau J, Cherezov V, Katritch V, Wang MW, ... Stevens RC, et al. Structure of the human glucagon class B G-protein-coupled receptor. Nature. 499: 444-9. PMID 23863937 DOI: 10.1038/nature12393  1
2013 Tao H, Lee SC, Moeller A, Roy RS, Siu FY, Zimmermann J, Stevens RC, Potter CS, Carragher B, Zhang Q. Engineered nanostructured β-sheet peptides protect membrane proteins. Nature Methods. 10: 759-61. PMID 23817067 DOI: 10.1038/nmeth.2533  1
2013 Jacky BP, Garay PE, Dupuy J, Nelson JB, Cai B, Molina Y, Wang J, Steward LE, Broide RS, Francis J, Aoki KR, Stevens RC, Fernández-Salas E. Identification of fibroblast growth factor receptor 3 (FGFR3) as a protein receptor for botulinum neurotoxin serotype A (BoNT/A). Plos Pathogens. 9: e1003369. PMID 23696738 DOI: 10.1371/journal.ppat.1003369  1
2013 Wang C, Wu H, Katritch V, Han GW, Huang XP, Liu W, Siu FY, Roth BL, Cherezov V, Stevens RC. Structure of the human smoothened receptor bound to an antitumour agent. Nature. 497: 338-43. PMID 23636324 DOI: 10.1038/nature12167  1
2013 Kufareva I, Stephens B, Gilliland CT, Wu B, Fenalti G, Hamel D, Stevens RC, Abagyan R, Handel TM. A novel approach to quantify G-protein-coupled receptor dimerization equilibrium using bioluminescence resonance energy transfer. Methods in Molecular Biology (Clifton, N.J.). 1013: 93-127. PMID 23625495 DOI: 10.1007/978-1-62703-426-5_7  1
2013 Otrubova K, Brown M, McCormick MS, Han GW, O'Neal ST, Cravatt BF, Stevens RC, Lichtman AH, Boger DL. Rational design of fatty acid amide hydrolase inhibitors that act by covalently bonding to two active site residues. Journal of the American Chemical Society. 135: 6289-99. PMID 23581831 DOI: 10.1021/ja4014997  1
2013 Rosen H, Stevens RC, Hanson M, Roberts E, Oldstone MB. Sphingosine-1-phosphate and its receptors: structure, signaling, and influence. Annual Review of Biochemistry. 82: 637-62. PMID 23527695 DOI: 10.1146/annurev-biochem-062411-130916  1
2013 Wacker D, Wang C, Katritch V, Han GW, Huang XP, Vardy E, McCorvy JD, Jiang Y, Chu M, Siu FY, Liu W, Xu HE, Cherezov V, Roth BL, Stevens RC. Structural features for functional selectivity at serotonin receptors. Science (New York, N.Y.). 340: 615-9. PMID 23519215 DOI: 10.1126/science.1232808  1
2013 Wang C, Jiang Y, Ma J, Wu H, Wacker D, Katritch V, Han GW, Liu W, Huang XP, Vardy E, McCorvy JD, Gao X, Zhou XE, Melcher K, Zhang C, ... ... Stevens RC, et al. Structural basis for molecular recognition at serotonin receptors. Science (New York, N.Y.). 340: 610-4. PMID 23519210 DOI: 10.1126/science.1232807  1
2013 Lee SC, Bennett BC, Hong WX, Fu Y, Baker KA, Marcoux J, Robinson CV, Ward AB, Halpert JR, Stevens RC, Stout CD, Yeager MJ, Zhang Q. Steroid-based facial amphiphiles for stabilization and crystallization of membrane proteins. Proceedings of the National Academy of Sciences of the United States of America. 110: E1203-11. PMID 23479627 DOI: 10.1073/pnas.1221442110  1
2013 Pieper U, Schlessinger A, Kloppmann E, Chang GA, Chou JJ, Dumont ME, Fox BG, Fromme P, Hendrickson WA, Malkowski MG, Rees DC, Stokes DL, Stowell MH, Wiener MC, Rost B, ... ... Stevens RC, et al. Coordinating the impact of structural genomics on the human α-helical transmembrane proteome. Nature Structural & Molecular Biology. 20: 135-8. PMID 23381628 DOI: 10.1038/nsmb.2508  1
2013 Stevens RC, Cherezov V, Katritch V, Abagyan R, Kuhn P, Rosen H, Wüthrich K. The GPCR Network: a large-scale collaboration to determine human GPCR structure and function. Nature Reviews. Drug Discovery. 12: 25-34. PMID 23237917 DOI: 10.1038/nrd3859  0.92
2013 Katritch V, Cherezov V, Stevens RC. Structure-function of the G protein-coupled receptor superfamily. Annual Review of Pharmacology and Toxicology. 53: 531-56. PMID 23140243 DOI: 10.1146/annurev-pharmtox-032112-135923  0.92
2013 Horst R, Stanczak P, Stevens RC, Wüthrich K. β2-Adrenergic receptor solutions for structural biology analyzed with microscale NMR diffusion measurements. Angewandte Chemie (International Ed. in English). 52: 331-5. PMID 23097212 DOI: 10.1002/anie.201205474  0.84
2013 Webb DR, Handel TM, Kretz-Rommel A, Stevens RC. Opportunities for functional selectivity in GPCR antibodies. Biochemical Pharmacology. 85: 147-52. PMID 22975405 DOI: 10.1016/j.bcp.2012.08.021  1
2012 Sarkissian CN, Gamez A, Scott P, Dauvillier J, Dorenbaum A, Scriver CR, Stevens RC. Chaperone-like therapy with tetrahydrobiopterin in clinical trials for phenylketonuria: is genotype a predictor of response? Jimd Reports. 5: 59-70. PMID 23430918 DOI: 10.1007/8904_2011_96  0.36
2012 Santos JS, Asmar-Rovira GA, Han GW, Liu W, Syeda R, Cherezov V, Baker KA, Stevens RC, Montal M. Crystal structure of a voltage-gated K+ channel pore module in a closed state in lipid membranes. The Journal of Biological Chemistry. 287: 43063-70. PMID 23095758 DOI: 10.1074/jbc.M112.415091  1
2012 Liu W, Chun E, Thompson AA, Chubukov P, Xu F, Katritch V, Han GW, Roth CB, Heitman LH, IJzerman AP, Cherezov V, Stevens RC. Structural basis for allosteric regulation of GPCRs by sodium ions. Science (New York, N.Y.). 337: 232-6. PMID 22798613 DOI: 10.1126/science.1219218  1
2012 Tao H, Fu Y, Thompson A, Lee SC, Mahoney N, Stevens RC, Zhang Q. Synthesis and properties of dodecyl trehaloside detergents for membrane protein studies. Langmuir : the Acs Journal of Surfaces and Colloids. 28: 11173-81. PMID 22780816 DOI: 10.1021/la3020404  1
2012 Chun E, Thompson AA, Liu W, Roth CB, Griffith MT, Katritch V, Kunken J, Xu F, Cherezov V, Hanson MA, Stevens RC. Fusion partner toolchest for the stabilization and crystallization of G protein-coupled receptors. Structure (London, England : 1993). 20: 967-76. PMID 22681902 DOI: 10.1016/j.str.2012.04.010  1
2012 Thompson AA, Liu W, Chun E, Katritch V, Wu H, Vardy E, Huang XP, Trapella C, Guerrini R, Calo G, Roth BL, Cherezov V, Stevens RC. Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic. Nature. 485: 395-9. PMID 22596163 DOI: 10.1038/nature11085  1
2012 Ferrero DM, Wacker D, Roque MA, Baldwin MW, Stevens RC, Liberles SD. Agonists for 13 trace amine-associated receptors provide insight into the molecular basis of odor selectivity. Acs Chemical Biology. 7: 1184-9. PMID 22545963 DOI: 10.1021/cb300111e  1
2012 Tosh DK, Phan K, Gao ZG, Gakh AA, Xu F, Deflorian F, Abagyan R, Stevens RC, Jacobson KA, Katritch V. Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening. Journal of Medicinal Chemistry. 55: 4297-308. PMID 22486652 DOI: 10.1021/jm300095s  1
2012 Derti A, Garrett-Engele P, Macisaac KD, Stevens RC, Sriram S, Chen R, Rohl CA, Johnson JM, Babak T. A quantitative atlas of polyadenylation in five mammals. Genome Research. 22: 1173-83. PMID 22454233 DOI: 10.1101/gr.132563.111  0.36
2012 Wu H, Wacker D, Mileni M, Katritch V, Han GW, Vardy E, Liu W, Thompson AA, Huang XP, Carroll FI, Mascarella SW, Westkaemper RB, Mosier PD, Roth BL, Cherezov V, ... Stevens RC, et al. Structure of the human κ-opioid receptor in complex with JDTic. Nature. 485: 327-32. PMID 22437504 DOI: 10.1038/nature10939  1
2012 Hanson MA, Roth CB, Jo E, Griffith MT, Scott FL, Reinhart G, Desale H, Clemons B, Cahalan SM, Schuerer SC, Sanna MG, Han GW, Kuhn P, Rosen H, Stevens RC. Crystal structure of a lipid G protein-coupled receptor. Science (New York, N.Y.). 335: 851-5. PMID 22344443 DOI: 10.1126/science.1215904  1
2012 Liu JJ, Horst R, Katritch V, Stevens RC, Wüthrich K. Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR. Science (New York, N.Y.). 335: 1106-10. PMID 22267580 DOI: 10.1126/science.1215802  0.84
2012 Deflorian F, Kumar TS, Phan K, Gao ZG, Xu F, Wu H, Katritch V, Stevens RC, Jacobson KA. Evaluation of molecular modeling of agonist binding in light of the crystallographic structure of an agonist-bound Aâ‚‚A adenosine receptor. Journal of Medicinal Chemistry. 55: 538-52. PMID 22104008 DOI: 10.1021/jm201461q  1
2012 Katritch V, Cherezov V, Stevens RC. Diversity and modularity of G protein-coupled receptor structures. Trends in Pharmacological Sciences. 33: 17-27. PMID 22032986 DOI: 10.1016/j.tips.2011.09.003  0.92
2011 Thompson AA, Liu JJ, Chun E, Wacker D, Wu H, Cherezov V, Stevens RC. GPCR stabilization using the bicelle-like architecture of mixed sterol-detergent micelles. Methods (San Diego, Calif.). 55: 310-7. PMID 22041719 DOI: 10.1016/j.ymeth.2011.10.011  1
2011 de Graaf C, Kooistra AJ, Vischer HF, Katritch V, Kuijer M, Shiroishi M, Iwata S, Shimamura T, Stevens RC, de Esch IJ, Leurs R. Crystal structure-based virtual screening for fragment-like ligands of the human histamine H(1) receptor. Journal of Medicinal Chemistry. 54: 8195-206. PMID 22007643 DOI: 10.1021/jm2011589  1
2011 Xu F, Stevens RC. Trapping small caffeine in a large GPCR pocket. Structure (London, England : 1993). 19: 1204-7. PMID 21893281 DOI: 10.1016/j.str.2011.08.007  1
2011 West GM, Chien EY, Katritch V, Gatchalian J, Chalmers MJ, Stevens RC, Griffin PR. Ligand-dependent perturbation of the conformational ensemble for the GPCR β2 adrenergic receptor revealed by HDX. Structure (London, England : 1993). 19: 1424-32. PMID 21889352 DOI: 10.1016/j.str.2011.08.001  1
2011 Kufareva I, Rueda M, Katritch V, Stevens RC, Abagyan R. Status of GPCR modeling and docking as reflected by community-wide GPCR Dock 2010 assessment. Structure (London, England : 1993). 19: 1108-26. PMID 21827947 DOI: 10.1016/j.str.2011.05.012  1
2011 Sarkissian CN, Kang TS, Gámez A, Scriver CR, Stevens RC. Evaluation of orally administered PEGylated phenylalanine ammonia lyase in mice for the treatment of Phenylketonuria. Molecular Genetics and Metabolism. 104: 249-54. PMID 21803624 DOI: 10.1016/j.ymgme.2011.06.016  1
2011 Shimamura T, Shiroishi M, Weyand S, Tsujimoto H, Winter G, Katritch V, Abagyan R, Cherezov V, Liu W, Han GW, Kobayashi T, Stevens RC, Iwata S. Structure of the human histamine H1 receptor complex with doxepin. Nature. 475: 65-70. PMID 21697825 DOI: 10.1038/nature10236  1
2011 Xu F, Liu W, Hanson MA, Stevens RC, Cherezov V. Development of an Automated High Throughput LCP-FRAP Assay to Guide Membrane Protein Crystallization in Lipid Mesophases. Crystal Growth & Design. 11: 1193-1201. PMID 21660116 DOI: 10.1021/cg101385e  1
2011 Miller MT, Mileni M, Comoletti D, Stevens RC, Harel M, Taylor P. The crystal structure of the α-neurexin-1 extracellular region reveals a hinge point for mediating synaptic adhesion and function. Structure (London, England : 1993). 19: 767-78. PMID 21620717 DOI: 10.1016/j.str.2011.03.011  1
2011 Jacobson MJ, Lin G, Tepp W, Dupuy J, Stenmark P, Stevens RC, Johnson EA. Purification, modeling, and analysis of botulinum neurotoxin subtype A5 (BoNT/A5) from Clostridium botulinum strain A661222. Applied and Environmental Microbiology. 77: 4217-22. PMID 21515732 DOI: 10.1128/AEM.00201-11  1
2011 Thompson AA, Jiao GS, Kim S, Thai A, Cregar-Hernandez L, Margosiak SA, Johnson AT, Han GW, O'Malley S, Stevens RC. Structural characterization of three novel hydroxamate-based zinc chelating inhibitors of the Clostridium botulinum serotype A neurotoxin light chain metalloprotease reveals a compact binding site resulting from 60/70 loop flexibility. Biochemistry. 50: 4019-28. PMID 21434688 DOI: 10.1021/bi2001483  0.84
2011 Ezzili C, Mileni M, McGlinchey N, Long JZ, Kinsey SG, Hochstatter DG, Stevens RC, Lichtman AH, Cravatt BF, Bilsky EJ, Boger DL. Reversible competitive α-ketoheterocycle inhibitors of fatty acid amide hydrolase containing additional conformational constraints in the acyl side chain: orally active, long-acting analgesics. Journal of Medicinal Chemistry. 54: 2805-22. PMID 21428410 DOI: 10.1021/jm101597x  1
2011 Xu F, Wu H, Katritch V, Han GW, Jacobson KA, Gao ZG, Cherezov V, Stevens RC. Structure of an agonist-bound human A2A adenosine receptor. Science (New York, N.Y.). 332: 322-7. PMID 21393508 DOI: 10.1126/science.1202793  1
2011 Mileni M, Garfunkle J, Ezzili C, Cravatt BF, Stevens RC, Boger DL. Fluoride-mediated capture of a noncovalent bound state of a reversible covalent enzyme inhibitor: X-ray crystallographic analysis of an exceptionally potent α-ketoheterocycle inhibitor of fatty acid amide hydrolase. Journal of the American Chemical Society. 133: 4092-100. PMID 21355555 DOI: 10.1021/ja110877y  1
2010 Chien EY, Liu W, Zhao Q, Katritch V, Han GW, Hanson MA, Shi L, Newman AH, Javitch JA, Cherezov V, Stevens RC. Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist. Science (New York, N.Y.). 330: 1091-5. PMID 21097933 DOI: 10.1126/science.1197410  1
2010 Wu B, Chien EY, Mol CD, Fenalti G, Liu W, Katritch V, Abagyan R, Brooun A, Wells P, Bi FC, Hamel DJ, Kuhn P, Handel TM, Cherezov V, Stevens RC. Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science (New York, N.Y.). 330: 1066-71. PMID 20929726 DOI: 10.1126/science.1194396  1
2010 Siu FY, Stevens RC. RAMP-ing up class-B GPCR ECD structural coverage. Structure (London, England : 1993). 18: 1067-8. PMID 20826331 DOI: 10.1016/j.str.2010.08.004  1
2010 Wacker D, Fenalti G, Brown MA, Katritch V, Abagyan R, Cherezov V, Stevens RC. Conserved binding mode of human beta2 adrenergic receptor inverse agonists and antagonist revealed by X-ray crystallography. Journal of the American Chemical Society. 132: 11443-5. PMID 20669948 DOI: 10.1021/ja105108q  1
2010 Cherezov V, Abola E, Stevens RC. Recent progress in the structure determination of GPCRs, a membrane protein family with high potential as pharmaceutical targets. Methods in Molecular Biology (Clifton, N.J.). 654: 141-68. PMID 20665265 DOI: 10.1007/978-1-60761-762-4_8  0.92
2010 Michino M, Chen J, Stevens RC, Brooks CL. FoldGPCR: structure prediction protocol for the transmembrane domain of G protein-coupled receptors from class A. Proteins. 78: 2189-201. PMID 20544957 DOI: 10.1002/prot.22731  0.56
2010 Mileni M, Kamtekar S, Wood DC, Benson TE, Cravatt BF, Stevens RC. Crystal structure of fatty acid amide hydrolase bound to the carbamate inhibitor URB597: discovery of a deacylating water molecule and insight into enzyme inactivation. Journal of Molecular Biology. 400: 743-54. PMID 20493882 DOI: 10.1016/j.jmb.2010.05.034  1
2010 Liu W, Hanson MA, Stevens RC, Cherezov V. LCP-Tm: an assay to measure and understand stability of membrane proteins in a membrane environment. Biophysical Journal. 98: 1539-48. PMID 20409473 DOI: 10.1016/j.bpj.2009.12.4296  1
2010 Hong WX, Baker KA, Ma X, Stevens RC, Yeager M, Zhang Q. Design, synthesis, and properties of branch-chained maltoside detergents for stabilization and crystallization of integral membrane proteins: human connexin 26. Langmuir : the Acs Journal of Surfaces and Colloids. 26: 8690-6. PMID 20232919 DOI: 10.1021/la904893d  1
2010 Stenmark P, Dong M, Dupuy J, Chapman ER, Stevens RC. Crystal structure of the botulinum neurotoxin type G binding domain: insight into cell surface binding. Journal of Molecular Biology. 397: 1287-97. PMID 20219474 DOI: 10.1016/j.jmb.2010.02.041  1
2010 Jaakola VP, Lane JR, Lin JY, Katritch V, Ijzerman AP, Stevens RC. Ligand binding and subtype selectivity of the human A(2A) adenosine receptor: identification and characterization of essential amino acid residues. The Journal of Biological Chemistry. 285: 13032-44. PMID 20147292 DOI: 10.1074/jbc.M109.096974  1
2010 Dong J, Thompson AA, Fan Y, Lou J, Conrad F, Ho M, Pires-Alves M, Wilson BA, Stevens RC, Marks JD. A single-domain llama antibody potently inhibits the enzymatic activity of botulinum neurotoxin by binding to the non-catalytic alpha-exosite binding region. Journal of Molecular Biology. 397: 1106-18. PMID 20138889 DOI: 10.1016/j.jmb.2010.01.070  0.84
2010 Katritch V, Jaakola VP, Lane JR, Lin J, Ijzerman AP, Yeager M, Kufareva I, Stevens RC, Abagyan R. Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists. Journal of Medicinal Chemistry. 53: 1799-809. PMID 20095623 DOI: 10.1021/jm901647p  1
2010 Zhang X, Chien EY, Chalmers MJ, Pascal BD, Gatchalian J, Stevens RC, Griffin PR. Dynamics of the beta2-adrenergic G-protein coupled receptor revealed by hydrogen-deuterium exchange. Analytical Chemistry. 82: 1100-8. PMID 20058880 DOI: 10.1021/ac902484p  1
2010 Mileni M, Garfunkle J, Ezzili C, Kimball FS, Cravatt BF, Stevens RC, Boger DL. X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase. Journal of Medicinal Chemistry. 53: 230-40. PMID 19924997 DOI: 10.1021/jm9012196  1
2010 Kang TS, Wang L, Sarkissian CN, Gámez A, Scriver CR, Stevens RC. Converting an injectable protein therapeutic into an oral form: phenylalanine ammonia lyase for phenylketonuria. Molecular Genetics and Metabolism. 99: 4-9. PMID 19793667 DOI: 10.1016/j.ymgme.2009.09.002  0.92
2009 Kang TS, Stevens RC. Structural aspects of therapeutic enzymes to treat metabolic disorders. Human Mutation. 30: 1591-610. PMID 19790257 DOI: 10.1002/humu.21111  1
2009 Mileni M, Garfunkle J, DeMartino JK, Cravatt BF, Boger DL, Stevens RC. Binding and inactivation mechanism of a humanized fatty acid amide hydrolase by alpha-ketoheterocycle inhibitors revealed from cocrystal structures. Journal of the American Chemical Society. 131: 10497-506. PMID 19722626 DOI: 10.1021/ja902694n  1
2009 Hanson MA, Stevens RC. Retraction: Cocrystal structure of synaptobrevin-II bound to botulinum neurotoxin type B at 2.0 A resolution. Nature Structural & Molecular Biology. 16: 795. PMID 19578378 DOI: 10.1038/nsmb0709-795  1
2009 Cherezov V, Hanson MA, Griffith MT, Hilgart MC, Sanishvili R, Nagarajan V, Stepanov S, Fischetti RF, Kuhn P, Stevens RC. Rastering strategy for screening and centring of microcrystal samples of human membrane proteins with a sub-10 microm size X-ray synchrotron beam. Journal of the Royal Society, Interface / the Royal Society. 6: S587-97. PMID 19535414 DOI: 10.1098/rsif.2009.0142.focus  1
2009 Michino M, Abola E, Brooks CL, Dixon JS, Moult J, Stevens RC. Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008. Nature Reviews. Drug Discovery. 8: 455-63. PMID 19461661 DOI: 10.1038/nrd2877  1
2009 Ahn K, Johnson DS, Mileni M, Beidler D, Long JZ, McKinney MK, Weerapana E, Sadagopan N, Liimatta M, Smith SE, Lazerwith S, Stiff C, Kamtekar S, Bhattacharya K, Zhang Y, ... ... Stevens RC, et al. Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain. Chemistry & Biology. 16: 411-20. PMID 19389627 DOI: 10.1016/j.chembiol.2009.02.013  1
2009 Hanson MA, Stevens RC. Discovery of new GPCR biology: one receptor structure at a time. Structure (London, England : 1993). 17: 8-14. PMID 19141277 DOI: 10.1016/j.str.2008.12.003  1
2008 Cherezov V, Liu J, Griffith M, Hanson MA, Stevens RC. LCP-FRAP Assay for Pre-Screening Membrane Proteins for in Meso Crystallization. Crystal Growth & Design. 8: 4307-4315. PMID 19234616 DOI: 10.1021/cg800778j  1
2008 Sarkissian CN, Gámez A, Wang L, Charbonneau M, Fitzpatrick P, Lemontt JF, Zhao B, Vellard M, Bell SM, Henschell C, Lambert A, Tsuruda L, Stevens RC, Scriver CR. Preclinical evaluation of multiple species of PEGylated recombinant phenylalanine ammonia lyase for the treatment of phenylketonuria. Proceedings of the National Academy of Sciences of the United States of America. 105: 20894-9. PMID 19095795 DOI: 10.1073/pnas.0808421105  1
2008 Barglow KT, Saikatendu KS, Bracey MH, Huey R, Morris GM, Olson AJ, Stevens RC, Cravatt BF. Functional proteomic and structural insights into molecular recognition in the nitrilase family enzymes. Biochemistry. 47: 13514-23. PMID 19053248 DOI: 10.1021/bi801786y  1
2008 Holden LG, Prochnow C, Chang YP, Bransteitter R, Chelico L, Sen U, Stevens RC, Goodman MF, Chen XS. Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications. Nature. 456: 121-4. PMID 18849968 DOI: 10.1038/nature07357  1
2008 Jaakola VP, Griffith MT, Hanson MA, Cherezov V, Chien EY, Lane JR, Ijzerman AP, Stevens RC. The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist. Science (New York, N.Y.). 322: 1211-7. PMID 18832607 DOI: 10.1126/science.1164772  1
2008 Mileni M, Johnson DS, Wang Z, Everdeen DS, Liimatta M, Pabst B, Bhattacharya K, Nugent RA, Kamtekar S, Cravatt BF, Ahn K, Stevens RC. Structure-guided inhibitor design for human FAAH by interspecies active site conversion. Proceedings of the National Academy of Sciences of the United States of America. 105: 12820-4. PMID 18753625 DOI: 10.1073/pnas.0806121105  1
2008 Stenmark P, Dupuy J, Imamura A, Kiso M, Stevens RC. Crystal structure of botulinum neurotoxin type A in complex with the cell surface co-receptor GT1b-insight into the toxin-neuron interaction. Plos Pathogens. 4: e1000129. PMID 18704164 DOI: 10.1371/journal.ppat.1000129  1
2008 Slaymaker IM, Bracey M, Mileni M, Garfunkle J, Cravatt BF, Boger DL, Stevens RC. Correlation of inhibitor effects on enzyme activity and thermal stability for the integral membrane protein fatty acid amide hydrolase. Bioorganic & Medicinal Chemistry Letters. 18: 5847-50. PMID 18644727 DOI: 10.1016/j.bmcl.2008.06.086  1
2008 Asmar-Rovira GA, Asseo-García AM, Quesada O, Hanson MA, Cheng A, Nogueras C, Lasalde-Dominicci JA, Stevens RC. Biophysical and ion channel functional characterization of the Torpedo californica nicotinic acetylcholine receptor in varying detergent-lipid environments. The Journal of Membrane Biology. 223: 13-26. PMID 18581036 DOI: 10.1007/s00232-008-9107-7  1
2008 Wang L, Gamez A, Archer H, Abola EE, Sarkissian CN, Fitzpatrick P, Wendt D, Zhang Y, Vellard M, Bliesath J, Bell SM, Lemontt JF, Scriver CR, Stevens RC. Structural and biochemical characterization of the therapeutic Anabaena variabilis phenylalanine ammonia lyase. Journal of Molecular Biology. 380: 623-35. PMID 18556022 DOI: 10.1016/j.jmb.2008.05.025  1
2008 Hanson MA, Cherezov V, Griffith MT, Roth CB, Jaakola VP, Chien EY, Velasquez J, Kuhn P, Stevens RC. A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor. Structure (London, England : 1993). 16: 897-905. PMID 18547522 DOI: 10.1016/j.str.2008.05.001  1
2008 Ng JD, Stevens RC, Kuhn P. Protein crystallization in restricted geometry: advancing old ideas for modern times in structural proteomics. Methods in Molecular Biology (Clifton, N.J.). 426: 363-76. PMID 18542876 DOI: 10.1007/978-1-60327-058-8_23  0.68
2008 Zhang Q, Horst R, Geralt M, Ma X, Hong WX, Finn MG, Stevens RC, Wüthrich K. Microscale NMR screening of new detergents for membrane protein structural biology. Journal of the American Chemical Society. 130: 7357-63. PMID 18479092 DOI: 10.1021/ja077863d  0.84
2008 Neuman BW, Joseph JS, Saikatendu KS, Serrano P, Chatterjee A, Johnson MA, Liao L, Klaus JP, Yates JR, Wüthrich K, Stevens RC, Buchmeier MJ, Kuhn P. Proteomics analysis unravels the functional repertoire of coronavirus nonstructural protein 3. Journal of Virology. 82: 5279-94. PMID 18367524 DOI: 10.1128/JVI.02631-07  0.84
2008 Alexandrov AI, Mileni M, Chien EY, Hanson MA, Stevens RC. Microscale fluorescent thermal stability assay for membrane proteins. Structure (London, England : 1993). 16: 351-9. PMID 18334210 DOI: 10.1016/j.str.2008.02.004  1
2008 Gräslund S, Nordlund P, Weigelt J, Hallberg BM, Bray J, Gileadi O, Knapp S, Oppermann U, Arrowsmith C, Hui R, Ming J, dhe-Paganon S, ... ... Stevens RC, et al. Protein production and purification. Nature Methods. 5: 135-46. PMID 18235434 DOI: 10.1038/nmeth.f.202  1
2008 Roth CB, Hanson MA, Stevens RC. Stabilization of the human beta2-adrenergic receptor TM4-TM3-TM5 helix interface by mutagenesis of Glu122(3.41), a critical residue in GPCR structure. Journal of Molecular Biology. 376: 1305-19. PMID 18222471 DOI: 10.1016/j.jmb.2007.12.028  1
2008 Ng JD, Clark PJ, Stevens RC, Kuhn P. In situ X-ray analysis of protein crystals in low-birefringent and X-ray transmissive plastic microchannels. Acta Crystallographica. Section D, Biological Crystallography. 64: 189-97. PMID 18219119 DOI: 10.1107/S0907444907060064  1
2008 Jauch R, Ng CK, Saikatendu KS, Stevens RC, Kolatkar PR. Crystal structure and DNA binding of the homeodomain of the stem cell transcription factor Nanog. Journal of Molecular Biology. 376: 758-70. PMID 18177668 DOI: 10.1016/j.jmb.2007.11.091  0.64
2008 Mathews II, McMullan D, Miller MD, Canaves JM, Elsliger MA, Floyd R, Grzechnik SK, Jaroszewski L, Klock HE, Koesema E, Kovarik JS, Kreusch A, Kuhn P, McPhillips TM, Morse AT, ... ... Stevens RC, et al. Crystal structure of 2-keto-3-deoxygluconate kinase (TM0067) from Thermotoga maritima at 2.05 A resolution. Proteins. 70: 603-8. PMID 18004772 DOI: 10.1002/prot.21842  1
2007 Cherezov V, Rosenbaum DM, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Kuhn P, Weis WI, Kobilka BK, Stevens RC. High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science (New York, N.Y.). 318: 1258-65. PMID 17962520 DOI: 10.1126/science.1150577  1
2007 Rosenbaum DM, Cherezov V, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Yao XJ, Weis WI, Stevens RC, Kobilka BK. GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function. Science (New York, N.Y.). 318: 1266-73. PMID 17962519 DOI: 10.1126/science.1150609  1
2007 Serrano P, Johnson MA, Almeida MS, Horst R, Herrmann T, Joseph JS, Neuman BW, Subramanian V, Saikatendu KS, Buchmeier MJ, Stevens RC, Kuhn P, Wüthrich K. Nuclear magnetic resonance structure of the N-terminal domain of nonstructural protein 3 from the severe acute respiratory syndrome coronavirus. Journal of Virology. 81: 12049-60. PMID 17728234 DOI: 10.1128/JVI.00969-07  0.84
2007 Hanson MA, Brooun A, Baker KA, Jaakola VP, Roth C, Chien EY, Alexandrov A, Velasquez J, Davis L, Griffith M, Moy K, Ganser-Pornillos BK, Hua Y, Kuhn P, Ellis S, ... ... Stevens RC, et al. Profiling of membrane protein variants in a baculovirus system by coupling cell-surface detection with small-scale parallel expression. Protein Expression and Purification. 56: 85-92. PMID 17723307 DOI: 10.1016/j.pep.2007.06.003  1
2007 Zhang Q, Ma X, Ward A, Hong WX, Jaakola VP, Stevens RC, Finn MG, Chang G. Designing facial amphiphiles for the stabilization of integral membrane proteins. Angewandte Chemie (International Ed. in English). 46: 7023-5. PMID 17691085 DOI: 10.1002/anie.200701556  1
2007 Wang L, Surendran S, Michals-Matalon K, Bhatia G, Tanskley S, Koch R, Grady J, Tyring SK, Stevens RC, Guttler F, Matalon R. Mutations in the regulatory domain of phenylalanine hydroxylase and response to tetrahydrobiopterin. Genetic Testing. 11: 174-8. PMID 17627389 DOI: 10.1089/gte.2006.0520  0.44
2007 Gámez A, Wang L, Sarkissian CN, Wendt D, Fitzpatrick P, Lemontt JF, Scriver CR, Stevens RC. Structure-based epitope and PEGylation sites mapping of phenylalanine ammonia-lyase for enzyme substitution treatment of phenylketonuria. Molecular Genetics and Metabolism. 91: 325-34. PMID 17560821 DOI: 10.1016/j.ymgme.2007.04.015  0.44
2007 Joseph JS, Saikatendu KS, Subramanian V, Neuman BW, Buchmeier MJ, Stevens RC, Kuhn P. Crystal structure of a monomeric form of severe acute respiratory syndrome coronavirus endonuclease nsp15 suggests a role for hexamerization as an allosteric switch. Journal of Virology. 81: 6700-8. PMID 17409150 DOI: 10.1128/JVI.02817-06  1
2007 Saikatendu KS, Joseph JS, Subramanian V, Neuman BW, Buchmeier MJ, Stevens RC, Kuhn P. Ribonucleocapsid formation of severe acute respiratory syndrome coronavirus through molecular action of the N-terminal domain of N protein. Journal of Virology. 81: 3913-21. PMID 17229691 DOI: 10.1128/JVI.02236-06  1
2007 Garcia-Rodriguez C, Levy R, Arndt JW, Forsyth CM, Razai A, Lou J, Geren I, Stevens RC, Marks JD. Molecular evolution of antibody cross-reactivity for two subtypes of type A botulinum neurotoxin. Nature Biotechnology. 25: 107-16. PMID 17173035 DOI: 10.1038/nbt1269  1
2006 Chai Q, Arndt JW, Dong M, Tepp WH, Johnson EA, Chapman ER, Stevens RC. Structural basis of cell surface receptor recognition by botulinum neurotoxin B. Nature. 444: 1096-100. PMID 17167418 DOI: 10.1038/nature05411  1
2006 Gerdts CJ, Tereshko V, Yadav MK, Dementieva I, Collart F, Joachimiak A, Stevens RC, Kuhn P, Kossiakoff A, Ismagilov RF. Time-controlled microfluidic seeding in nL-volume droplets to separate nucleation and growth stages of protein crystallization Angewandte Chemie - International Edition. 45: 8156-8160. PMID 17099920 DOI: 10.1002/anie.200602946  1
2006 Kosloff M, Han GW, Krishna SS, Schwarzenbacher R, Fasnacht M, Elsliger MA, Abdubek P, Agarwalla S, Ambing E, Astakhova T, Axelrod HL, Canaves JM, Carlton D, Chiu HJ, Clayton T, ... ... Stevens RC, et al. Comparative structural analysis of a novel glutathioneS-transferase (ATU5508) from Agrobacterium tumefaciens at 2.0 A resolution. Proteins. 65: 527-37. PMID 16988933 DOI: 10.1002/prot.21130  1
2006 Xu Q, Krishna SS, McMullan D, Schwarzenbacher R, Miller MD, Abdubek P, Agarwalla S, Ambing E, Astakhova T, Axelrod HL, Canaves JM, Carlton D, Chiu HJ, Clayton T, DiDonato M, ... ... Stevens RC, et al. Crystal structure of an ORFan protein (TM1622) from Thermotoga maritima at 1.75 A resolution reveals a fold similar to the Ran-binding protein Mog1p. Proteins. 65: 777-82. PMID 16948158 DOI: 10.1002/prot.21015  1
2006 Arndt JW, Jacobson MJ, Abola EE, Forsyth CM, Tepp WH, Marks JD, Johnson EA, Stevens RC. A structural perspective of the sequence variability within botulinum neurotoxin subtypes A1-A4. Journal of Molecular Biology. 362: 733-42. PMID 16938310 DOI: 10.1016/j.jmb.2006.07.040  1
2006 DiDonato M, Krishna SS, Schwarzenbacher R, McMullan D, Agarwalla S, Brittain SM, Miller MD, Abdubek P, Ambing E, Axelrod HL, Canaves JM, Chiu HJ, Deacon AM, Duan L, Elsliger MA, ... ... Stevens RC, et al. Crystal structure of 2-phosphosulfolactate phosphatase (ComB) from Clostridium acetobutylicum at 2.6 A resolution reveals a new fold with a novel active site. Proteins. 65: 771-6. PMID 16927339 DOI: 10.1002/prot.20978  1
2006 Joseph JS, Saikatendu KS, Subramanian V, Neuman BW, Brooun A, Griffith M, Moy K, Yadav MK, Velasquez J, Buchmeier MJ, Stevens RC, Kuhn P. Crystal structure of nonstructural protein 10 from the severe acute respiratory syndrome coronavirus reveals a novel fold with two zinc-binding motifs. Journal of Virology. 80: 7894-901. PMID 16873246 DOI: 10.1128/JVI.00467-06  1
2006 Mathews II, Krishna SS, Schwarzenbacher R, McMullan D, Jaroszewski L, Miller MD, Abdubek P, Agarwalla S, Ambing E, Axelrod HL, Canaves JM, Carlton D, Chiu HJ, Clayton T, DiDonato M, ... ... Stevens RC, et al. Crystal structure of phosphoribosylformyl-glycinamidine synthase II, PurS subunit (TM1244) from Thermotoga maritima at 1.90 A resolution. Proteins. 65: 249-54. PMID 16865708 DOI: 10.1002/prot.21024  1
2006 Schwarzenbacher R, McMullan D, Krishna SS, Xu Q, Miller MD, Canaves JM, Elsliger MA, Floyd R, Grzechnik SK, Jaroszewski L, Klock HE, Koesema E, Kovarik JS, Kreusch A, Kuhn P, ... ... Stevens RC, et al. Crystal structure of a glycerate kinase (TM1585) from Thermotoga maritima at 2.70 A resolution reveals a new fold. Proteins. 65: 243-8. PMID 16865707 DOI: 10.1002/prot.21058  1
2006 Xu Q, Schwarzenbacher R, Krishna SS, McMullan D, Agarwalla S, Quijano K, Abdubek P, Ambing E, Axelrod H, Biorac T, Canaves JM, Chiu HJ, Elsliger MA, Grittini C, Grzechnik SK, ... ... Stevens RC, et al. Crystal structure of acireductone dioxygenase (ARD) from Mus musculus at 2.06 angstrom resolution. Proteins. 64: 808-13. PMID 16783794 DOI: 10.1002/prot.20947  1
2006 Han GW, Sri Krishna S, Schwarzenbacher R, McMullan D, Ginalski K, Elsliger MA, Brittain SM, Abdubek P, Agarwalla S, Ambing E, Astakhova T, Axelrod H, Canaves JM, Chiu HJ, DiDonato M, ... ... Stevens RC, et al. Crystal structure of the ApbE protein (TM1553) from Thermotoga maritima at 1.58 A resolution. Proteins. 64: 1083-90. PMID 16779835 DOI: 10.1002/prot.20950  1
2006 Ratia K, Saikatendu KS, Santarsiero BD, Barretto N, Baker SC, Stevens RC, Mesecar AD. Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme. Proceedings of the National Academy of Sciences of the United States of America. 103: 5717-22. PMID 16581910 DOI: 10.1073/pnas.0510851103  1
2006 Mathews II, Krishna SS, Schwarzenbacher R, McMullan D, Abdubek P, Ambing E, Canaves JM, Chiu HJ, Deacon AM, DiDonato M, Elsliger MA, Godzik A, Grittini C, Grzechnik SK, Hale J, ... ... Stevens RC, et al. Crystal structure of phosphoribosylformylglycinamidine synthase II (smPurL) from Thermotoga maritima at 2.15 A resolution. Proteins. 63: 1106-11. PMID 16544324 DOI: 10.1002/prot.20650  1
2006 Jin KK, Krishna SS, Schwarzenbacher R, McMullan D, Abdubek P, Agarwalla S, Ambing E, Axelrod H, Canaves JM, Chiu HJ, Deacon AM, DiDonato M, Elsliger MA, Feuerhelm J, Godzik A, ... ... Stevens RC, et al. Crystal structure of TM1367 from Thermotoga maritima at 1.90 A resolution reveals an atypical member of the cyclophilin (peptidylprolyl isomerase) fold. Proteins. 63: 1112-8. PMID 16544291 DOI: 10.1002/prot.20894  1
2006 Arndt JW, Chai Q, Christian T, Stevens RC. Structure of botulinum neurotoxin type D light chain at 1.65 A resolution: repercussions for VAMP-2 substrate specificity. Biochemistry. 45: 3255-62. PMID 16519520 DOI: 10.1021/bi052518r  0.52
2006 DiDonato M, Krishna SS, Schwarzenbacher R, McMullan D, Jaroszewski L, Miller MD, Abdubek P, Agarwalla S, Ambing E, Axelrod H, Biorac T, Chiu HJ, Deacon AM, Elsliger MA, Feuerhelm J, ... ... Stevens RC, et al. Crystal structure of a single-stranded DNA-binding protein (TM0604) from Thermotoga maritima at 2.60 A resolution. Proteins. 63: 256-60. PMID 16435371 DOI: 10.1002/prot.20841  1
2006 Xu Q, Schwarzenbacher R, McMullan D, Abdubek P, Agarwalla S, Ambing E, Axelrod H, Biorac T, Canaves JM, Chiu HJ, Deacon AM, DiDonato M, Elsliger MA, Godzik A, Grittini C, ... ... Stevens RC, et al. Crystal structure of virulence factor CJ0248 from Campylobacter jejuni at 2.25 A resolution reveals a new fold. Proteins. 62: 292-6. PMID 16287129 DOI: 10.1002/prot.20611  1
2005 Yadav MK, Gerdts CJ, Sanishvili R, Smith WW, Roach LS, Ismagilov RF, Kuhn P, Stevens RC. In situ data collection and structure refinement from microcapillary protein crystallization. Journal of Applied Crystallography. 38: 900-905. PMID 17468785 DOI: 10.1107/S002188980502649X  0.68
2005 Collins B, Stevens RC, Page R. Crystallization Optimum Solubility Screening: using crystallization results to identify the optimal buffer for protein crystal formation. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 61: 1035-8. PMID 16511228 DOI: 10.1107/S1744309105035244  1
2005 Peti W, Page R, Moy K, O'Neil-Johnson M, Wilson IA, Stevens RC, Wüthrich K. Towards miniaturization of a structural genomics pipeline using micro-expression and microcoil NMR. Journal of Structural and Functional Genomics. 6: 259-67. PMID 16283429 DOI: 10.1007/s10969-005-9000-x  1
2005 Saikatendu KS, Joseph JS, Subramanian V, Clayton T, Griffith M, Moy K, Velasquez J, Neuman BW, Buchmeier MJ, Stevens RC, Kuhn P. Structural basis of severe acute respiratory syndrome coronavirus ADP-ribose-1''-phosphate dephosphorylation by a conserved domain of nsP3. Structure (London, England : 1993). 13: 1665-75. PMID 16271890 DOI: 10.1016/j.str.2005.07.022  1
2005 Klock HE, Schwarzenbacher R, Xu Q, McMullan D, Abdubek P, Ambing E, Axelrod H, Biorac T, Canaves JM, Chiu HJ, Deacon AM, DiDonato M, Elsliger MA, Godzik A, Grittini C, ... ... Stevens RC, et al. Crystal structure of a conserved hypothetical protein (gi: 13879369) from Mouse at 1.90 A resolution reveals a new fold. Proteins. 61: 1132-6. PMID 16224779 DOI: 10.1002/prot.20610  1
2005 Page R, Deacon AM, Lesley SA, Stevens RC. Shotgun crystallization strategy for structural genomics II: crystallization conditions that produce high resolution structures for T. maritima proteins. Journal of Structural and Functional Genomics. 6: 209-17. PMID 16211521 DOI: 10.1007/s10969-005-1916-7  1
2005 Peti W, Johnson MA, Herrmann T, Neuman BW, Buchmeier MJ, Nelson M, Joseph J, Page R, Stevens RC, Kuhn P, Wüthrich K. Structural genomics of the severe acute respiratory syndrome coronavirus: nuclear magnetic resonance structure of the protein nsP7. Journal of Virology. 79: 12905-13. PMID 16188992 DOI: 10.1128/JVI.79.20.12905-12913.2005  1
2005 Jaroszewski L, Schwarzenbacher R, McMullan D, Abdubek P, Agarwalla S, Ambing E, Axelrod H, Biorac T, Canaves JM, Chiu HJ, Deacon AM, DiDonato M, Elsliger MA, Godzik A, Grittini C, ... ... Stevens RC, et al. Crystal structure of Hsp33 chaperone (TM1394) from Thermotoga maritima at 2.20 A resolution. Proteins. 61: 669-73. PMID 16167343 DOI: 10.1002/prot.20542  1
2005 Chappie JS, Cànaves JM, Han GW, Rife CL, Xu Q, Stevens RC. The structure of a eukaryotic nicotinic acid phosphoribosyltransferase reveals structural heterogeneity among type II PRTases. Structure (London, England : 1993). 13: 1385-96. PMID 16154095 DOI: 10.1016/j.str.2005.05.016  1
2005 Rife C, Schwarzenbacher R, McMullan D, Abdubek P, Ambing E, Axelrod H, Biorac T, Canaves JM, Chiu HJ, Deacon AM, DiDonato M, Elsliger MA, Godzik A, Grittini C, Grzechnik SK, ... ... Stevens RC, et al. Crystal structure of a putative modulator of DNA gyrase (pmbA) from Thermotoga maritima at 1.95 A resolution reveals a new fold. Proteins. 61: 444-8. PMID 16104019 DOI: 10.1002/prot.20468  1
2005 Rife C, Schwarzenbacher R, McMullan D, Abdubek P, Ambing E, Axelrod H, Biorac T, Canaves JM, Chiu HJ, Deacon AM, DiDonato M, Elsliger MA, Godzik A, Grittini C, Grzechnik SK, ... ... Stevens RC, et al. Crystal structure of the global regulatory protein CsrA from Pseudomonas putida at 2.05 A resolution reveals a new fold. Proteins. 61: 449-53. PMID 16104018 DOI: 10.1002/prot.20502  1
2005 Ricci JS, Stevens RC, McMullan RK, Klooster WT. Structure of strontium hydroxide octahydrate, Sr(OH)2.8H2O, at 20, 100 and 200 K from neutron diffraction. Acta Crystallographica. Section B, Structural Science. 61: 381-6. PMID 16041087 DOI: 10.1107/S0108768105013480  1
2005 Arndt JW, Yu W, Bi F, Stevens RC. Crystal structure of botulinum neurotoxin type G light chain: serotype divergence in substrate recognition. Biochemistry. 44: 9574-80. PMID 16008342 DOI: 10.1021/bi0505924  0.52
2005 Wang L, Gamez A, Sarkissian CN, Straub M, Patch MG, Han GW, Striepeke S, Fitzpatrick P, Scriver CR, Stevens RC. Structure-based chemical modification strategy for enzyme replacement treatment of phenylketonuria. Molecular Genetics and Metabolism. 86: 134-40. PMID 16006165 DOI: 10.1016/j.ymgme.2005.05.012  0.84
2005 Han GW, Schwarzenbacher R, McMullan D, Abdubek P, Ambing E, Axelrod H, Biorac T, Canaves JM, Chiu HJ, Dai X, Deacon AM, DiDonato M, Elsliger MA, Godzik A, Grittini C, ... ... Stevens RC, et al. Crystal structure of an Apo mRNA decapping enzyme (DcpS) from Mouse at 1.83 A resolution. Proteins. 60: 797-802. PMID 16001405 DOI: 10.1002/prot.20467  1
2005 Gámez A, Sarkissian CN, Wang L, Kim W, Straub M, Patch MG, Chen L, Striepeke S, Fitzpatrick P, Lemontt JF, O'Neill C, Scriver CR, Stevens RC. Development of pegylated forms of recombinant Rhodosporidium toruloides phenylalanine ammonia-lyase for the treatment of classical phenylketonuria. Molecular Therapy : the Journal of the American Society of Gene Therapy. 11: 986-9. PMID 15922970 DOI: 10.1016/j.ymthe.2005.02.013  0.44
2005 Mathews I, Schwarzenbacher R, McMullan D, Abdubek P, Ambing E, Axelrod H, Biorac T, Canaves JM, Chiu HJ, Deacon AM, DiDonato M, Elsliger MA, Godzik A, Grittini C, Grzechnik SK, ... ... Stevens RC, et al. Crystal structure of S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA) from Thermotoga maritima at 2.0 A resolution reveals a new fold. Proteins. 59: 869-74. PMID 15822125 DOI: 10.1002/prot.20419  1
2005 Levin I, Miller MD, Schwarzenbacher R, McMullan D, Abdubek P, Ambing E, Biorac T, Cambell J, Canaves JM, Chiu HJ, Deacon AM, DiDonato M, Elsliger MA, Godzik A, Grittini C, ... ... Stevens RC, et al. Crystal structure of an indigoidine synthase A (IndA)-like protein (TM1464) from Thermotoga maritima at 1.90 A resolution reveals a new fold. Proteins. 59: 864-8. PMID 15822122 DOI: 10.1002/prot.20420  1
2005 Arndt JW, Gu J, Jaroszewski L, Schwarzenbacher R, Hanson MA, Lebeda FJ, Stevens RC. The structure of the neurotoxin-associated protein HA33/A from Clostridium botulinum suggests a reoccurring beta-trefoil fold in the progenitor toxin complex. Journal of Molecular Biology. 346: 1083-93. PMID 15701519 DOI: 10.1016/j.jmb.2004.12.039  1
2005 Page R, Peti W, Wilson IA, Stevens RC, Wüthrich K. NMR screening and crystal quality of bacterially expressed prokaryotic and eukaryotic proteins in a structural genomics pipeline. Proceedings of the National Academy of Sciences of the United States of America. 102: 1901-5. PMID 15677718 DOI: 10.1073/pnas.0408490102  1
2005 Han GW, Schwarzenbacher R, Page R, Jaroszewski L, Abdubek P, Ambing E, Biorac T, Canaves JM, Chiu HJ, Dai X, Deacon AM, DiDonato M, Elsliger MA, Godzik A, Grittini C, ... ... Stevens RC, et al. Crystal structure of an alanine-glyoxylate aminotransferase from Anabaena sp. at 1.70 A resolution reveals a noncovalently linked PLP cofactor. Proteins. 58: 971-5. PMID 15657930 DOI: 10.1002/prot.20360  1
2005 Xu Q, Schwarzenbacher R, McMullan D, Abdubek P, Ambing E, Biorac T, Canaves JM, Chiu HJ, Dai X, Deacon AM, DiDonato M, Elsliger MA, Godzik A, Grittini C, Grzechnik SK, ... ... Stevens RC, et al. Crystal structure of a formiminotetrahydrofolate cyclodeaminase (TM1560) from Thermotoga maritima at 2.80 A resolution reveals a new fold. Proteins. 58: 976-81. PMID 15651027 DOI: 10.1002/prot.20364  1
2005 Arndt JW, Schwarzenbacher R, Page R, Abdubek P, Ambing E, Biorac T, Canaves JM, Chiu HJ, Dai X, Deacon AM, DiDonato M, Elsliger MA, Godzik A, Grittini C, Grzechnik SK, ... ... Stevens RC, et al. Crystal structure of an alpha/beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 1.85 A resolution. Proteins. 58: 755-8. PMID 15624212 DOI: 10.1002/prot.20336  1
2004 Erlandsen H, Pey AL, Gámez A, Pérez B, Desviat LR, Aguado C, Koch R, Surendran S, Tyring S, Matalon R, Scriver CR, Ugarte M, Martínez A, Stevens RC. Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations. Proceedings of the National Academy of Sciences of the United States of America. 101: 16903-8. PMID 15557004 DOI: 10.1073/pnas.0407256101  1
2004 Canaves JM, Page R, Wilson IA, Stevens RC. Protein biophysical properties that correlate with crystallization success in Thermotoga maritima: maximum clustering strategy for structural genomics. Journal of Molecular Biology. 344: 977-91. PMID 15544807 DOI: 10.1016/j.jmb.2004.09.076  1
2004 Page R, Moy K, Sims EC, Velasquez J, McManus B, Grittini C, Clayton TL, Stevens RC. Scalable high-throughput micro-expression device for recombinant proteins. Biotechniques. 37: 364, 366, 368 passim. PMID 15470889  1
2004 Pey AL, Pérez B, Desviat LR, Martínez MA, Aguado C, Erlandsen H, Gámez A, Stevens RC, Thórólfsson M, Ugarte M, Martínez A. Mechanisms underlying responsiveness to tetrahydrobiopterin in mild phenylketonuria mutations. Human Mutation. 24: 388-99. PMID 15459954 DOI: 10.1002/humu.20097  1
2004 Miller MD, Schwarzenbacher R, von Delft F, Abdubek P, Ambing E, Biorac T, Brinen LS, Canaves JM, Cambell J, Chiu HJ, Dai X, Deacon AM, DiDonato M, Elsliger MA, Eshagi S, ... ... Stevens RC, et al. Crystal structure of a tandem cystathionine-beta-synthase (CBS) domain protein (TM0935) from Thermotoga maritima at 1.87 A resolution. Proteins. 57: 213-7. PMID 15326606 DOI: 10.1002/prot.20024  1
2004 Page R, Stevens RC. Crystallization data mining in structural genomics: using positive and negative results to optimize protein crystallization screens. Methods (San Diego, Calif.). 34: 373-89. PMID 15325655 DOI: 10.1016/j.ymeth.2004.03.026  1
2004 Kim W, Erlandsen H, Surendran S, Stevens RC, Gamez A, Michols-Matalon K, Tyring SK, Matalon R. Trends in enzyme therapy for phenylketonuria. Molecular Therapy : the Journal of the American Society of Gene Therapy. 10: 220-4. PMID 15294168 DOI: 10.1016/j.ymthe.2004.05.001  1
2004 Shen Z, Go EP, Gamez A, Apon JV, Fokin V, Greig M, Ventura M, Crowell JE, Blixt O, Paulson JC, Stevens RC, Finn MG, Siuzdak G. A mass spectrometry plate reader: monitoring enzyme activity and inhibition with a Desorption/Ionization on Silicon (DIOS) platform. Chembiochem : a European Journal of Chemical Biology. 5: 921-7. PMID 15239048 DOI: 10.1002/cbic.200400008  1
2004 Levin I, Schwarzenbacher R, McMullan D, Abdubek P, Ambing E, Biorac T, Cambell J, Canaves JM, Chiu HJ, Dai X, Deacon AM, DiDonato M, Elsliger MA, Godzik A, Grittini C, ... ... Stevens RC, et al. Crystal structure of a putative NADPH-dependent oxidoreductase (GI: 18204011) from mouse at 2.10 A resolution. Proteins. 56: 629-33. PMID 15229897 DOI: 10.1002/prot.20163  1
2004 Xu Q, Schwarzenbacher R, Page R, Sims E, Abdubek P, Ambing E, Biorac T, Brinen LS, Cambell J, Canaves JM, Chiu HJ, Dai X, Deacon AM, DiDonato M, Elsliger MA, ... ... Stevens RC, et al. Crystal structure of an allantoicase (YIR029W) from Saccharomyces cerevisiae at 2.4 A resolution. Proteins. 56: 619-24. PMID 15229895 DOI: 10.1002/prot.20164  1
2004 McMullan D, Schwarzenbacher R, Jaroszewski L, von Delft F, Klock HE, Vincent J, Quijano K, Abdubek P, Ambing E, Biorac T, Brinen LS, Canaves JM, Dai X, Deacon AM, DiDonato M, ... ... Stevens RC, et al. Crystal structure of a novel Thermotoga maritima enzyme (TM1112) from the cupin family at 1.83 A resolution. Proteins. 56: 615-8. PMID 15229894 DOI: 10.1002/prot.20139  1
2004 Jaroszewski L, Schwarzenbacher R, von Delft F, McMullan D, Brinen LS, Canaves JM, Dai X, Deacon AM, DiDonato M, Elsliger MA, Eshagi S, Floyd R, Godzik A, Grittini C, Grzechnik SK, ... ... Stevens RC, et al. Crystal structure of a novel manganese-containing cupin (TM1459) from Thermotoga maritima at 1.65 A resolution. Proteins. 56: 611-4. PMID 15229893 DOI: 10.1002/prot.20130  1
2004 Bakolitsa C, Schwarzenbacher R, McMullan D, Brinen LS, Canaves JM, Dai X, Deacon AM, Elsliger MA, Eshagi S, Floyd R, Godzik A, Grittini C, Grzechnik SK, Jaroszewski L, Karlak C, ... ... Stevens RC, et al. Crystal structure of an orphan protein (TM0875) from Thermotoga maritima at 2.00-A resolution reveals a new fold. Proteins. 56: 607-10. PMID 15229892 DOI: 10.1002/prot.20138  1
2004 Levin I, Schwarzenbacher R, Page R, Abdubek P, Ambing E, Biorac T, Brinen LS, Campbell J, Canaves JM, Chiu HJ, Dai X, Deacon AM, DiDonato M, Elsliger MA, Floyd R, ... ... Stevens RC, et al. Crystal structure of a PIN (PilT N-terminus) domain (AF0591) from Archaeoglobus fulgidus at 1.90 A resolution. Proteins. 56: 404-8. PMID 15211526 DOI: 10.1002/prot.20090  1
2004 Spraggon G, Schwarzenbacher R, Kreusch A, McMullan D, Brinen LS, Canaves JM, Dai X, Deacon AM, Elsliger MA, Eshagi S, Floyd R, Godzik A, Grittini C, Grzechnik SK, Jaroszewski L, ... ... Stevens RC, et al. Crystal structure of a methionine aminopeptidase (TM1478) from Thermotoga maritima at 1.9 A resolution. Proteins. 56: 396-400. PMID 15211524 DOI: 10.1002/prot.20084  1
2004 Schwarzenbacher R, von Delft F, Jaroszewski L, Abdubek P, Ambing E, Biorac T, Brinen LS, Canaves JM, Cambell J, Chiu HJ, Dai X, Deacon AM, DiDonato M, Elsliger MA, Eshagi S, ... ... Stevens RC, et al. Crystal structure of a putative oxalate decarboxylase (TM1287) from Thermotoga maritima at 1.95 A resolution. Proteins. 56: 392-5. PMID 15211523 DOI: 10.1002/prot.20016  1
2004 Heine A, Canaves JM, von Delft F, Brinen LS, Dai X, Deacon AM, Elsliger MA, Eshaghi S, Floyd R, Godzik A, Grittini C, Grzechnik SK, Guda C, Jaroszewski L, Karlak C, ... ... Stevens RC, et al. Crystal structure of O-acetylserine sulfhydrylase (TM0665) from Thermotoga maritima at 1.8 A resolution. Proteins. 56: 387-91. PMID 15211522 DOI: 10.1002/prot.20003  1
2004 Xu Q, Schwarzenbacher R, McMullan D, von Delft F, Brinen LS, Canaves JM, Dai X, Deacon AM, Elsliger MA, Eshagi S, Floyd R, Godzik A, Grittini C, Grzechnik SK, Jaroszewski L, ... ... Stevens RC, et al. Crystal structure of a ribose-5-phosphate isomerase RpiB (TM1080) from Thermotoga maritima at 1.90 A resolution. Proteins. 56: 171-5. PMID 15162497 DOI: 10.1002/prot.20129  1
2004 Santelli E, Schwarzenbacher R, McMullan D, Biorac T, Brinen LS, Canaves JM, Cambell J, Dai X, Deacon AM, Elsliger MA, Eshagi S, Floyd R, Godzik A, Grittini C, Grzechnik SK, ... ... Stevens RC, et al. Crystal structure of a glycerophosphodiester phosphodiesterase (GDPD) from Thermotoga maritima (TM1621) at 1.60 A resolution. Proteins. 56: 167-70. PMID 15162496 DOI: 10.1002/prot.20120  1
2004 Spraggon G, Schwarzenbacher R, Kreusch A, Lee CC, Abdubek P, Ambing E, Biorac T, Brinen LS, Canaves JM, Cambell J, Chiu HJ, Dai X, Deacon AM, DiDonato M, Elsliger MA, ... ... Stevens RC, et al. Crystal structure of an Udp-n-acetylmuramate-alanine ligase MurC (TM0231) from Thermotoga maritima at 2.3 A resolution. Proteins. 55: 1078-81. PMID 15146505 DOI: 10.1002/prot.20034  1
2004 Schwarzenbacher R, Jaroszewski L, von Delft F, Abdubek P, Ambing E, Biorac T, Brinen LS, Canaves JM, Cambell J, Chiu HJ, Dai X, Deacon AM, DiDonato M, Elsliger MA, Eshagi S, ... ... Stevens RC, et al. Crystal structure of a type II quinolic acid phosphoribosyltransferase (TM1645) from Thermotoga maritima at 2.50 A resolution. Proteins. 55: 768-71. PMID 15103640 DOI: 10.1002/prot.20029  1
2004 Schwarzenbacher R, Jaroszewski L, von Delft F, Abdubek P, Ambing E, Biorac T, Brinen LS, Canaves JM, Cambell J, Chiu HJ, Dai X, Deacon AM, DiDonato M, Elsliger MA, Eshagi S, ... ... Stevens RC, et al. Crystal structure of an aspartate aminotransferase (TM1255) from Thermotoga maritima at 1.90 A resolution. Proteins. 55: 759-63. PMID 15103638 DOI: 10.1002/prot.10646  1
2004 Schwarzenbacher R, Jaroszewski L, von Delft F, Abdubek P, Ambing E, Biorac T, Brinen LS, Canaves JM, Cambell J, Chiu HJ, Dai X, Deacon AM, DiDonato M, Elsliger MA, Eshagi S, ... ... Stevens RC, et al. Crystal structure of a phosphoribosylaminoimidazole mutase PurE (TM0446) from Thermotoga maritima at 1.77-A resolution. Proteins. 55: 474-8. PMID 15048837 DOI: 10.1002/prot.20023  1
2004 Schwarzenbacher R, von Delft F, Abdubek P, Ambing E, Biorac T, Brinen LS, Canaves JM, Cambell J, Chiu HJ, Dai X, Deacon AM, DiDonato M, Elsliger MA, Eshagi S, Floyd R, ... ... Stevens RC, et al. Crystal structure of a putative PII-like signaling protein (TM0021) from Thermotoga maritima at 2.5 A resolution. Proteins. 54: 810-3. PMID 14997579 DOI: 10.1002/prot.10647  1
2004 Erlandsen H, Canaves JM, Elsliger MA, von Delft F, Brinen LS, Dai X, Deacon AM, Floyd R, Godzik A, Grittini C, Grzechnik SK, Jaroszewski L, Klock HE, Koesema E, Kovarik JS, ... ... Stevens RC, et al. Crystal structure of an HEPN domain protein (TM0613) from Thermotoga maritima at 1.75 A resolution. Proteins. 54: 806-9. PMID 14997578 DOI: 10.1002/prot.10631  1
2004 Matalon R, Koch R, Michals-Matalon K, Moseley K, Surendran S, Tyring S, Erlandsen H, Gamez A, Stevens RC, Romstad A, Møller LB, Guttler F. Biopterin responsive phenylalanine hydroxylase deficiency. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 6: 27-32. PMID 14726806 DOI: 10.1097/01.GIM.0000108840.17922.A7  1
2004 Schwarzenbacher R, von Delft F, Canaves JM, Brinen LS, Dai X, Deacon AM, Elsliger MA, Eshaghi S, Floyd R, Godzik A, Grittini C, Grzechnik SK, Guda C, Jaroszewski L, Karlak C, ... ... Stevens RC, et al. Crystal structure of an iron-containing 1,3-propanediol dehydrogenase (TM0920) from Thermotoga maritima at 1.3 A resolution. Proteins. 54: 174-7. PMID 14705036 DOI: 10.1002/prot.10594  1
2003 Weselak M, Patch MG, Selby TL, Knebel G, Stevens RC. Robotics for automated crystal formation and analysis. Methods in Enzymology. 368: 45-76. PMID 14674268 DOI: 10.1016/S0076-6879(03)68004-3  1
2003 Erlandsen H, Patch MG, Gamez A, Straub M, Stevens RC. Structural studies on phenylalanine hydroxylase and implications toward understanding and treating phenylketonuria. Pediatrics. 112: 1557-65. PMID 14654665  1
2003 Schwarzenbacher R, Canaves JM, Brinen LS, Dai X, Deacon AM, Elsliger MA, Eshaghi S, Floyd R, Godzik A, Grittini C, Grzechnik SK, Guda C, Jaroszewski L, Karlak C, Klock HE, ... ... Stevens RC, et al. Crystal structure of uronate isomerase (TM0064) from Thermotoga maritima at 2.85 A resolution. Proteins. 53: 142-5. PMID 12945057 DOI: 10.1002/prot.10462  1
2003 Yin J, Beuscher AE, Andryski SE, Stevens RC, Schultz PG. Structural plasticity and the evolution of antibody affinity and specificity. Journal of Molecular Biology. 330: 651-6. PMID 12850137  1
2003 Yin J, Andryski SE, Beuscher AE, Stevens RC, Schultz PG. Structural evidence for substrate strain in antibody catalysis. Proceedings of the National Academy of Sciences of the United States of America. 100: 856-61. PMID 12552112 DOI: 10.1073/pnas.0235873100  1
2003 Brinen LS, Canaves JM, Dai X, Deacon AM, Elsliger MA, Eshaghi S, Floyd R, Godzik A, Grittini C, Grzechnik SK, Guda C, Jaroszewski L, Karlak C, Klock HE, Koesema E, ... ... Stevens RC, et al. Crystal structure of a zinc-containing glycerol dehydrogenase (TM0423) from Thermotoga maritima at 1.5 A resolution. Proteins. 50: 371-4. PMID 12486729 DOI: 10.1002/prot.10302  1
2002 Bracey MH, Hanson MA, Masuda KR, Stevens RC, Cravatt BF. Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling. Science (New York, N.Y.). 298: 1793-6. PMID 12459591 DOI: 10.1126/science.1076535  1
2002 Wang L, Erlandsen H, Haavik J, Knappskog PM, Stevens RC. Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin. Biochemistry. 41: 12569-74. PMID 12379098 DOI: 10.1021/bi026561f  1
2002 Kuhn P, Lesley SA, Mathews II, Canaves JM, Brinen LS, Dai X, Deacon AM, Elsliger MA, Eshaghi S, Floyd R, Godzik A, Grittini C, Grzechnik SK, Guda C, Hodgson KO, ... ... Stevens RC, et al. Crystal structure of thy1, a thymidylate synthase complementing protein from Thermotoga maritima at 2.25 A resolution. Proteins. 49: 142-5. PMID 12211025 DOI: 10.1002/prot.10202  1
2002 Lesley SA, Kuhn P, Godzik A, Deacon AM, Mathews I, Kreusch A, Spraggon G, Klock HE, McMullan D, Shin T, Vincent J, Robb A, Brinen LS, Miller MD, McPhillips TM, ... ... Stevens RC, et al. Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proceedings of the National Academy of Sciences of the United States of America. 99: 11664-9. PMID 12193646 DOI: 10.1073/pnas.142413399  1
2002 Erlandsen H, Kim JY, Patch MG, Han A, Volner A, Abu-Omar MM, Stevens RC. Structural comparison of bacterial and human iron-dependent phenylalanine hydroxylases: similar fold, different stability and reaction rates. Journal of Molecular Biology. 320: 645-61. PMID 12096915 DOI: 10.1016/S0022-2836(02)00496-5  1
2002 Song J, Cheng Q, Stevens RC. Morphological manipulation of bolaamphiphilic polydiacetylene assemblies by controlled lipid doping. Chemistry and Physics of Lipids. 114: 203-14. PMID 11934401  0.8
2001 Yin J, Mundorff EC, Yang PL, Wendt KU, Hanway D, Stevens RC, Schultz PG. A comparative analysis of the immunological evolution of antibody 28B4. Biochemistry. 40: 10764-73. PMID 11535051 DOI: 10.1021/bi010536c  1
2001 Song J, Cheng Q, Kopta S, Stevens RC. Modulating artificial membrane morphology: pH-induced chromatic transition and nanostructural transformation of a bolaamphiphilic conjugated polymer from blue helical ribbons to red nanofibers. Journal of the American Chemical Society. 123: 3205-13. PMID 11457054  0.8
2001 Erlandsen H, Stevens RC. A structural hypothesis for BH4 responsiveness in patients with mild forms of hyperphenylalaninaemia and phenylketonuria. Journal of Inherited Metabolic Disease. 24: 213-30. PMID 11405341 DOI: 10.1023/A:1010371002631  1
2001 Chen DW, Beuscher AE, Stevens RC, Wirsching P, Lerner RA, Janda KD. Preparation of stilbene-tethered nonnatural nucleosides for use with blue-fluorescent antibodies. The Journal of Organic Chemistry. 66: 1725-32. PMID 11262119 DOI: 10.1021/jo001676f  1
2001 Orencia MC, Yoon JS, Ness JE, Stemmer WP, Stevens RC. Predicting the emergence of antibiotic resistance by directed evolution and structural analysis. Nature Structural Biology. 8: 238-42. PMID 11224569 DOI: 10.1038/84981  0.64
2000 Rogers JP, Luginbühl P, Pemberton K, Harty P, Wemmer DE, Stevens RC. Structure-activity relationships in a peptidic alpha7 nicotinic acetylcholine receptor antagonist. Journal of Molecular Biology. 304: 911-26. PMID 11124036 DOI: 10.1006/jmbi.2000.4247  1
2000 Erlandsen H, Abola EE, Stevens RC. Combining structural genomics and enzymology: completing the picture in metabolic pathways and enzyme active sites. Current Opinion in Structural Biology. 10: 719-30. PMID 11114510 DOI: 10.1016/S0959-440X(00)00154-8  1
2000 Orencia MC, Hanson MA, Stevens RC. Structural analysis of affinity matured antibodies and laboratory-evolved enzymes. Advances in Protein Chemistry. 55: 227-59. PMID 11050935  1
2000 Simeonov A, Matsushita M, Juban EA, Thompson EH, Hoffman TZ, Beuscher AE, Taylor MJ, Wirsching P, Rettig W, McCusker JK, Stevens RC, Millar DP, Schultz PG, Lerner RA, Janda KD. Blue-fluorescent antibodies. Science (New York, N.Y.). 290: 307-13. PMID 11030644 DOI: 10.1126/science.290.5490.307  1
2000 Hanson MA, Stevens RC. Cocrystal structure of synaptobrevin-II bound to botulinum neurotoxin type B at 2.0 A resolution. Nature Structural Biology. 7: 687-92. PMID 10932255 DOI: 10.1038/77997  1
2000 Erlandsen H, Bjørgo E, Flatmark T, Stevens RC. Crystal structure and site-specific mutagenesis of pterin-bound human phenylalanine hydroxylase. Biochemistry. 39: 2208-17. PMID 10694386 DOI: 10.1021/bi992531+  1
2000 Mundorff EC, Hanson MA, Varvak A, Ulrich H, Schultz PG, Stevens RC. Conformational effects in biological catalysis: an antibody-catalyzed oxy-cope rearrangement. Biochemistry. 39: 627-32. PMID 10651626 DOI: 10.1021/bi9924314  1
1999 Spiller B, Gershenson A, Arnold FH, Stevens RC. A structural view of evolutionary divergence. Proceedings of the National Academy of Sciences of the United States of America. 96: 12305-10. PMID 10535917 DOI: 10.1073/pnas.96.22.12305  1
1999 Erlandsen H, Stevens RC. The structural basis of phenylketonuria. Molecular Genetics and Metabolism. 68: 103-25. PMID 10527663 DOI: 10.1006/mgme.1999.2922  1
1999 Lacy DB, Stevens RC. Sequence homology and structural analysis of the clostridial neurotoxins. Journal of Molecular Biology. 291: 1091-104. PMID 10518945 DOI: 10.1006/jmbi.1999.2945  1
1999 Kobe B, Jennings IG, House CM, Michell BJ, Goodwill KE, Santarsiero BD, Stevens RC, Cotton RG, Kemp BE. Structural basis of autoregulation of phenylalanine hydroxylase. Nature Structural Biology. 6: 442-8. PMID 10331871 DOI: 10.1038/8247  1
1999 Rogers JP, Luginbühl P, Shen GS, McCabe RT, Stevens RC, Wemmer DE. NMR solution structure of alpha-conotoxin ImI and comparison to other conotoxins specific for neuronal nicotinic acetylcholine receptors. Biochemistry. 38: 3874-82. PMID 10194298 DOI: 10.1021/bi9826254  1
1998 Lacy DB, Stevens RC. Unraveling the structures and modes of action of bacterial toxins. Current Opinion in Structural Biology. 8: 778-84. PMID 9914258 DOI: 10.1016/S0959-440X(98)80098-5  1
1998 Erlandsen H, Flatmark T, Stevens RC, Hough E. Crystallographic analysis of the human phenylalanine hydroxylase catalytic domain with bound catechol inhibitors at 2.0 A resolution. Biochemistry. 37: 15638-46. PMID 9843368 DOI: 10.1021/bi9815290  1
1998 Lacy DB, Tepp W, Cohen AC, DasGupta BR, Stevens RC. Crystal structure of botulinum neurotoxin type A and implications for toxicity. Nature Structural Biology. 5: 898-902. PMID 9783750 DOI: 10.1038/2338  1
1998 Romesberg FE, Santarsiero BD, Spiller B, Yin J, Barnes D, Schultz PG, Stevens RC. Structural and kinetic evidence for strain in biological catalysis. Biochemistry. 37: 14404-9. PMID 9772166 DOI: 10.1021/bi981578c  1
1998 Goodwill KE, Sabatier C, Stevens RC. Crystal structure of tyrosine hydroxylase with bound cofactor analogue and iron at 2.3 A resolution: self-hydroxylation of Phe300 and the pterin-binding site. Biochemistry. 37: 13437-45. PMID 9753429 DOI: 10.1021/bi981462g  1
1998 Kim CU, Lew W, Williams MA, Wu H, Zhang L, Chen X, Escarpe PA, Mendel DB, Laver WG, Stevens RC. Structure-activity relationship studies of novel carbocyclic influenza neuraminidase inhibitors. Journal of Medicinal Chemistry. 41: 2451-60. PMID 9651151 DOI: 10.1021/jm980162u  0.84
1998 Fusetti F, Erlandsen H, Flatmark T, Stevens RC. Structure of tetrameric human phenylalanine hydroxylase and its implications for phenylketonuria. The Journal of Biological Chemistry. 273: 16962-7. PMID 9642259 DOI: 10.1074/jbc.273.27.16962  1
1998 Romesberg FE, Spiller B, Schultz PG, Stevens RC. Immunological origins of binding and catalysis in a Diels-Alderase antibody. Science (New York, N.Y.). 279: 1929-33. PMID 9506942 DOI: 10.1126/science.279.5358.1929  1
1997 Erlandsen H, Fusetti F, Martinez A, Hough E, Flatmark T, Stevens RC. Crystal structure of the catalytic domain of human phenylalanine hydroxylase reveals the structural basis for phenylketonuria. Nature Structural Biology. 4: 995-1000. PMID 9406548  1
1997 Lacy DB, Stevens RC. Recombinant expression and purification of the botulinum neurotoxin type A translocation domain. Protein Expression and Purification. 11: 195-200. PMID 9367816 DOI: 10.1006/prep.1997.0772  1
1997 Ulrich HD, Mundorff E, Santarsiero BD, Driggers EM, Stevens RC, Schultz PG. The interplay between binding energy and catalysis in the evolution of a catalytic antibody. Nature. 389: 271-5. PMID 9305839 DOI: 10.1038/38470  1
1997 Goodwill KE, Sabatier C, Marks C, Raag R, Fitzpatrick PF, Stevens RC. Crystal structure of tyrosine hydroxylase at 2.3 A and its implications for inherited neurodegenerative diseases. Nature Structural Biology. 4: 578-85. PMID 9228951 DOI: 10.1038/nsb0797-578  1
1997 David NE, Gee M, Andersen B, Naider F, Thorner J, Stevens RC. Expression and purification of the Saccharomyces cerevisiae alpha-factor receptor (Ste2p), a 7-transmembrane-segment G protein-coupled receptor. The Journal of Biological Chemistry. 272: 15553-61. PMID 9182592 DOI: 10.1074/jbc.272.24.15553  1
1997 Wedemayer GJ, Patten PA, Wang LH, Schultz PG, Stevens RC. Structural insights into the evolution of an antibody combining site. Science (New York, N.Y.). 276: 1665-9. PMID 9180069 DOI: 10.1126/science.276.5319.1665  1
1997 Wedemayer GJ, Wang LH, Patten PA, Schultz PG, Stevens RC. Crystal structures of the free and liganded form of an esterolytic catalytic antibody. Journal of Molecular Biology. 268: 390-400. PMID 9159478 DOI: 10.1006/jmbi.1997.0974  1
1996 Patten PA, Gray NS, Yang PL, Marks CB, Wedemayer GJ, Boniface JJ, Stevens RC, Schultz PG. The immunological evolution of catalysis. Science (New York, N.Y.). 271: 1086-91. PMID 8599084  1
1995 Lagow RJ, Kampa JJ, Wei HC, Battle SL, Genge JW, Laude DA, Harper CJ, Bau R, Stevens RC, Haw JF, Munson E. Synthesis of Linear Acetylenic Carbon: The "sp" Carbon Allotrope. Science (New York, N.Y.). 267: 362-7. PMID 17837484 DOI: 10.1126/science.267.5196.362  1
1994 Yuan HS, Stevens RC, Bau R, Mosher HS, Koetzle TF. Determination of the absolute configuration of (+)-neopentyl-1-d alcohol by neutron and x-ray diffraction analysis. Proceedings of the National Academy of Sciences of the United States of America. 91: 12872-6. PMID 7809138 DOI: 10.1073/pnas.91.26.12872  1
1992 Stevens RC, Lipscomb WN. A molecular mechanism for pyrimidine and purine nucleotide control of aspartate transcarbamoylase. Proceedings of the National Academy of Sciences of the United States of America. 89: 5281-5. PMID 1608935 DOI: 10.1073/pnas.89.12.5281  1
1992 Stebbins JW, Robertson DE, Roberts MF, Stevens RC, Lipscomb WN, Kantrowitz ER. Arginine 54 in the active site of Escherichia coli aspartate transcarbamoylase is critical for catalysis: a site-specific mutagenesis, NMR, and X-ray crystallographic study. Protein Science : a Publication of the Protein Society. 1: 1435-46. PMID 1303763 DOI: 10.1002/pro.5560011105  1
1991 Stevens RC, Reinisch KM, Lipscomb WN. Molecular structure of Bacillus subtilis aspartate transcarbamoylase at 3.0 A resolution. Proceedings of the National Academy of Sciences of the United States of America. 88: 6087-91. PMID 1906175  1
1991 Stevens RC, Chook YM, Cho CY, Lipscomb WN, Kantrowitz ER. Escherichia coli aspartate carbamoyltransferase: the probing of crystal structure analysis via site-specific mutagenesis. Protein Engineering. 4: 391-408. PMID 1881865 DOI: 10.1093/protein/4.4.391  1
1990 Gouaux JE, Stevens RC, Lipscomb WN. Crystal structures of aspartate carbamoyltransferase ligated with phosphonoacetamide, malonate, and CTP or ATP at 2.8-A resolution and neutral pH. Biochemistry. 29: 7702-15. PMID 2271529  1
1990 Stevens RC, Gouaux JE, Lipscomb WN. Structural consequences of effector binding to the T state of aspartate carbamoyltransferase: crystal structures of the unligated and ATP- and CTP-complexed enzymes at 2.6-A resolution. Biochemistry. 29: 7691-701. PMID 2271528  1
1990 Stevens RC, Lipscomb WN. Allosteric control of quaternary states in E. coli aspartate transcarbamylase. Biochemical and Biophysical Research Communications. 171: 1312-8. PMID 2222446 DOI: 10.1016/0006-291X(90)90829-C  1
1989 Gouaux JE, Stevens RC, Ke HM, Lipscomb WN. Crystal structure of the Glu-239----Gln mutant of aspartate carbamoyltransferase at 3.1-A resolution: an intermediate quaternary structure. Proceedings of the National Academy of Sciences of the United States of America. 86: 8212-6. PMID 2573062  1
1988 Yuan HS, Stevens RC, Fujita S, Watkins MI, Koetzle TF, Bau R. Determination of the absolute configuration of (-)-(2R)-succinic-2-d acid by neutron diffraction study: unambiguous proof of the absolute stereochemistry of the NAD+/NADH interconversion. Proceedings of the National Academy of Sciences of the United States of America. 85: 2889-93. PMID 3362854  1
1988 Choi HK, Terzis A, Stevens RC, Bau R, Haugwitz R, Narayanan VL, Wolpert-DeFilippes M. Reaction products of a new anti-cancer agent, Pt(IV)(cyclohexyldiamine)Cl4, with guanosine and 9-methylguanine: first crystal structures of Pt(cyclohexyldiamine) complexes with a nucleobase and a nucleoside. Biochemical and Biophysical Research Communications. 156: 1120-4. PMID 3190689 DOI: 10.1016/S0006-291X(88)80748-4  1
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