| Year |
Citation |
Score |
| 2024 |
Park SY, Choi DH, Song J, Lakshmanan M, Richelle A, Yoon S, Kontoravdi C, Lewis NE, Lee DY. Driving towards digital biomanufacturing by CHO genome-scale models. Trends in Biotechnology. PMID 38548556 DOI: 10.1016/j.tibtech.2024.03.001 |
0.329 |
|
| 2024 |
Morrissey J, Strain B, Kontoravdi C. Flux Balance Analysis of Mammalian Cell Systems. Methods in Molecular Biology (Clifton, N.J.). 2774: 119-134. PMID 38441762 DOI: 10.1007/978-1-0716-3718-0_9 |
0.307 |
|
| 2024 |
Gopalakrishnan S, Johnson W, Valderrama-Gomez MA, Icten E, Tat J, Ingram M, Fung Shek C, Chan PK, Schlegel F, Rolandi P, Kontoravdi C, Lewis NE. COSMIC-dFBA: A novel multi-scale hybrid framework for bioprocess modeling. Metabolic Engineering. PMID 38387677 DOI: 10.1016/j.ymben.2024.02.012 |
0.321 |
|
| 2023 |
Triantafyllou N, Sarkis M, Krassakopoulou A, Shah N, Papathanasiou MM, Kontoravdi C. Uncertainty quantification for gene delivery methods: A roadmap for pDNA manufacturing from phase I clinical trials to commercialization. Biotechnology Journal. e2300103. PMID 37797343 DOI: 10.1002/biot.202300103 |
0.605 |
|
| 2023 |
Monteiro M, Fadda S, Kontoravdi C. Towards advanced bioprocess optimization: A multiscale modelling approach. Computational and Structural Biotechnology Journal. 21: 3639-3655. PMID 37520284 DOI: 10.1016/j.csbj.2023.07.003 |
0.391 |
|
| 2023 |
Jiménez Del Val I, Kyriakopoulos S, Albrecht S, Stockmann H, Rudd PM, Polizzi KM, Kontoravdi C. CHOmpact: A reduced metabolic model of Chinese hamster ovary cells with enhanced interpretability. Biotechnology and Bioengineering. PMID 37272445 DOI: 10.1002/bit.28459 |
0.319 |
|
| 2023 |
Strain B, Morrissey J, Antonakoudis A, Kontoravdi C. How reliable are Chinese Hamster Ovary (CHO) cell genome-scale metabolic models? Biotechnology and Bioengineering. PMID 36866411 DOI: 10.1002/bit.28366 |
0.306 |
|
| 2022 |
Alhuthali S, Kontoravdi C. Population balance modelling captures host cell protein dynamics in CHO cell cultures. Plos One. 17: e0265886. PMID 35320326 DOI: 10.1371/journal.pone.0265886 |
0.399 |
|
| 2022 |
Kis Z, Tak K, Ibrahim D, Papathanasiou MM, Chachuat B, Shah N, Kontoravdi C. Pandemic-response adenoviral vector and RNA vaccine manufacturing. Npj Vaccines. 7: 29. PMID 35236838 DOI: 10.1038/s41541-022-00447-3 |
0.567 |
|
| 2021 |
Ibrahim D, Kis Z, Tak K, Papathanasiou MM, Kontoravdi C, Chachuat B, Shah N. Model-Based Planning and Delivery of Mass Vaccination Campaigns against Infectious Disease: Application to the COVID-19 Pandemic in the UK. Vaccines. 9. PMID 34960206 DOI: 10.3390/vaccines9121460 |
0.551 |
|
| 2021 |
Makrydaki E, Marshall O, Heide C, Buldum G, Kontoravdi C, Polizzi KM. Cell-free protein synthesis using Chinese hamster ovary cells. Methods in Enzymology. 659: 411-435. PMID 34752298 DOI: 10.1016/bs.mie.2021.08.004 |
0.745 |
|
| 2020 |
Heide C, Buldum G, Moya-Ramirez I, Ces O, Kontoravdi C, Polizzi KM. Design, Development and Optimization of a Functional Mammalian Cell-Free Protein Synthesis Platform. Frontiers in Bioengineering and Biotechnology. 8: 604091. PMID 33604330 DOI: 10.3389/fbioe.2020.604091 |
0.746 |
|
| 2020 |
Kotidis P, Kontoravdi C. Harnessing the potential of artificial neural networks for predicting protein glycosylation. Metabolic Engineering Communications. 10: e00131. PMID 32489858 DOI: 10.1016/J.Mec.2020.E00131 |
0.398 |
|
| 2020 |
Thaore V, Tsourapas D, Shah N, Kontoravdi C. Techno-Economic Assessment of Cell-Free Synthesis of Monoclonal Antibodies Using CHO Cell Extracts Processes. 8: 454. DOI: 10.3390/pr8040454 |
0.359 |
|
| 2020 |
Papathanasiou MM, Kontoravdi C. Engineering challenges in therapeutic protein product and process design Current Opinion in Chemical Engineering. 27: 81-88. DOI: 10.1016/J.Coche.2019.11.010 |
0.655 |
|
| 2019 |
Moya Ramírez I, Kontoravdi C, Polizzi KM. Low-cost and user-friendly biosensor to test the integrity of mRNA molecules suitable for field applications. Biosensors & Bioelectronics. 137: 199-206. PMID 31100599 DOI: 10.1016/J.Bios.2019.05.008 |
0.334 |
|
| 2019 |
Kotidis P, Jedrzejewski P, Sou SN, Sellick C, Polizzi K, Del Val IJ, Kontoravdi C. Model-based optimization of antibody galactosylation in CHO cell culture. Biotechnology and Bioengineering. 116: 1612-1626. PMID 30802295 DOI: 10.1002/Bit.26960 |
0.416 |
|
| 2019 |
Kotidis P, Kontoravdi C. Strategic Framework for Parameterization of Cell Culture Models Processes. 7: 174. DOI: 10.3390/PR7030174 |
0.348 |
|
| 2019 |
Kotidis P, Demis P, Goey CH, Correa E, McIntosh C, Trepekli S, Shah N, Klymenko OV, Kontoravdi C. Constrained global sensitivity analysis for bioprocess design space identification Computers & Chemical Engineering. 125: 558-568. DOI: 10.1016/J.Compchemeng.2019.01.022 |
0.446 |
|
| 2019 |
Casula E, Traversari G, Fadda S, Klymenko OV, Kontoravdi C, Cincotti A. Modelling the osmotic behaviour of human mesenchymal stem cells Biochemical Engineering Journal. 151: 107296. DOI: 10.1016/J.Bej.2019.107296 |
0.36 |
|
| 2019 |
Goey CH, Bell D, Kontoravdi C. CHO cell cultures in shake flasks and bioreactors present different host cell protein profiles in the supernatant Biochemical Engineering Journal. 144: 185-192. DOI: 10.1016/J.Bej.2019.02.006 |
0.398 |
|
| 2019 |
Kis Z, Papathanasiou M, Calvo‐Serrano R, Kontoravdi C, Shah N. A model‐based quantification of the impact of new manufacturing technologies on developing country vaccine supply chain performance: A Kenyan case study Journal of Advanced Manufacturing and Processing. 1. DOI: 10.1002/AMP2.10025 |
0.553 |
|
| 2018 |
Goey CH, Alhuthali S, Kontoravdi C. Host cell protein removal from biopharmaceutical preparations: Towards the implementation of quality by design. Biotechnology Advances. 36: 1223-1237. PMID 29654903 DOI: 10.1016/J.Biotechadv.2018.03.021 |
0.467 |
|
| 2018 |
Goey CH, Bell D, Kontoravdi C. Mild hypothermic culture conditions affect residual host cell protein composition post-Protein A chromatography. Mabs. 0. PMID 29381421 DOI: 10.1080/19420862.2018.1433977 |
0.453 |
|
| 2018 |
Kontoravdi C, Val IJd. Computational tools for predicting and controlling the glycosylation of biopharmaceuticals Current Opinion in Chemical Engineering. 22: 89-97. DOI: 10.1016/J.Coche.2018.08.007 |
0.408 |
|
| 2017 |
Sou SN, Lee K, Nayyar K, Polizzi KM, Sellick C, Kontoravdi C. Exploring cellular behaviour under transient gene expression and its impact on mAb productivity and Fc-glycosylation. Biotechnology and Bioengineering. PMID 28921534 DOI: 10.1002/Bit.26456 |
0.435 |
|
| 2017 |
Goey CH, Tsang JMH, Bell D, Kontoravdi C. Cascading effect in bioprocessing - The impact of mild hypothermia on CHO cell behaviour and host cell protein composition. Biotechnology and Bioengineering. PMID 28843000 DOI: 10.1002/Bit.26437 |
0.43 |
|
| 2017 |
Cárdenas-Fernández M, Bawn M, Hamley-Bennett C, Bharat PKV, Subrizi F, Suhaili N, Ward DP, Bourdin S, Dalby PA, Hailes HC, Hewitson P, Ignatova S, Kontoravdi C, Leak DJ, Shah N, et al. An integrated biorefinery concept for conversion of sugar beet pulp into value-added chemicals and pharmaceutical intermediates. Faraday Discussions. PMID 28665423 DOI: 10.1039/C7Fd00094D |
0.345 |
|
| 2017 |
Goers L, Ainsworth C, Goey CH, Kontoravdi C, Freemont PS, Polizzi KM. Whole-cell Escherichia coli lactate biosensor for monitoring mammalian cell cultures during biopharmaceutical production. Biotechnology and Bioengineering. PMID 28112405 DOI: 10.1002/Bit.26254 |
0.447 |
|
| 2016 |
Sou SN, Jedrzejewski PM, Lee K, Sellick C, Polizzi KM, Kontoravdi C. Model-based investigation of intracellular processes determining antibody Fc-glycosylation under mild hypothermia. Biotechnology and Bioengineering. PMID 27869292 DOI: 10.1002/Bit.26225 |
0.471 |
|
| 2016 |
Del Val IJ, Polizzi KM, Kontoravdi C. A theoretical estimate for nucleotide sugar demand towards Chinese Hamster Ovary cellular glycosylation. Scientific Reports. 6: 28547. PMID 27345611 DOI: 10.1038/Srep28547 |
0.413 |
|
| 2016 |
Niu H, Shah N, Kontoravdi C. Modelling of amorphous cellulose depolymerisation by cellulases, parametric studies and optimisation. Biochemical Engineering Journal. 105: 455-472. PMID 26865832 DOI: 10.1016/J.Bej.2015.10.017 |
0.397 |
|
| 2016 |
Klymenko OV, Shah N, Kontoravdi C, Royle KE, Polizzi KM. Designing an Artificial Golgi reactor to achieve targeted glycosylation of monoclonal antibodies Aiche Journal. DOI: 10.1002/Aic.15388 |
0.392 |
|
| 2015 |
Oliveira PH, Mairhofer J, Alves PM, Lara AR, Kontoravdi C. Advances in the Development of Biotherapeutics. Biomed Research International. 2015: 793876. PMID 26078963 DOI: 10.1155/2015/793876 |
0.371 |
|
| 2015 |
Fan Y, Del Val IJ, Müller C, Lund AM, Sen JW, Rasmussen SK, Kontoravdi C, Baycin-Hizal D, Betenbaugh MJ, Weilguny D, Andersen MR. A multi-pronged investigation into the effect of glucose starvation and culture duration on fed-batch CHO cell culture. Biotechnology and Bioengineering. PMID 25899530 DOI: 10.1002/Bit.25620 |
0.437 |
|
| 2015 |
Sou SN, Sellick C, Lee K, Mason A, Kyriakopoulos S, Polizzi KM, Kontoravdi C. How does mild hypothermia affect monoclonal antibody glycosylation? Biotechnology and Bioengineering. 112: 1165-76. PMID 25545631 DOI: 10.1002/Bit.25524 |
0.426 |
|
| 2015 |
Fan Y, Jimenez Del Val I, Müller C, Wagtberg Sen J, Rasmussen SK, Kontoravdi C, Weilguny D, Andersen MR. Amino acid and glucose metabolism in fed-batch CHO cell culture affects antibody production and glycosylation. Biotechnology and Bioengineering. 112: 521-35. PMID 25220616 DOI: 10.1002/Bit.25450 |
0.423 |
|
| 2015 |
Sou SN, Sellick C, Lee K, Mason A, Kyriakopoulos S, Polizzi KM, Kontoravdi C. Understanding the impact of different bioprocess conditions on monoclonal antibody glycosylation in CHO cell cultures through experimental and computational analyses Bmc Proceedings. 9. DOI: 10.1186/1753-6561-9-S9-O6 |
0.365 |
|
| 2015 |
Niu H, Leak D, Shah N, Kontoravdi C. Metabolic characterization and modeling of fermentation process of an engineered Geobacillus thermoglucosidasius strain for bioethanol production with gas stripping Chemical Engineering Science. 122: 138-149. DOI: 10.1016/J.Ces.2014.09.004 |
0.349 |
|
| 2014 |
Kyriakopoulos S, Kontoravdi C. A framework for the systematic design of fed-batch strategies in mammalian cell culture. Biotechnology and Bioengineering. 111: 2466-76. PMID 24975682 DOI: 10.1002/Bit.25319 |
0.434 |
|
| 2014 |
Jedrzejewski PM, del Val IJ, Constantinou A, Dell A, Haslam SM, Polizzi KM, Kontoravdi C. Towards controlling the glycoform: a model framework linking extracellular metabolites to antibody glycosylation. International Journal of Molecular Sciences. 15: 4492-522. PMID 24637934 DOI: 10.3390/Ijms15034492 |
0.442 |
|
| 2014 |
Behjousiar A, Constantinou A, Polizzi KM, Kontoravdi C. FIBS-enabled noninvasive metabolic profiling. Journal of Visualized Experiments : Jove. e51200. PMID 24513729 DOI: 10.3791/51200 |
0.409 |
|
| 2014 |
Chen N, Bennett MH, Kontoravdi C. Analysis of Chinese hamster ovary cell metabolism through a combined computational and experimental approach. Cytotechnology. 66: 945-66. PMID 24292563 DOI: 10.1007/S10616-013-9648-1 |
0.464 |
|
| 2014 |
Kyriakopoulos S, Kontoravdi C. Insights on biomarkers from Chinese hamster ovary omics studies Pharmaceutical Bioprocessing. 2: 389-401. DOI: 10.4155/Pbp.14.45 |
0.362 |
|
| 2014 |
Todri E, Amenaghawon AN, Val IJd, Leak DJ, Kontoravdi C, Kucherenko S, Shah N. Global sensitivity analysis and meta-modeling of an ethanol production process Chemical Engineering Science. 114: 114-127. DOI: 10.1016/J.Ces.2014.04.027 |
0.302 |
|
| 2013 |
Kyriakopoulos S, Polizzi KM, Kontoravdi C. Comparative analysis of amino acid metabolism and transport in CHO variants with different levels of productivity. Journal of Biotechnology. 168: 543-51. PMID 24056080 DOI: 10.1016/J.Jbiotec.2013.09.007 |
0.343 |
|
| 2013 |
del Val IJ, Kyriakopoulos S, Polizzi KM, Kontoravdi C. An optimized method for extraction and quantification of nucleotides and nucleotide sugars from mammalian cells. Analytical Biochemistry. 443: 172-80. PMID 24036437 DOI: 10.1016/J.Ab.2013.09.005 |
0.366 |
|
| 2013 |
Kontoravdi C. Systematic methodology for the development of mathematical models for biological processes. Methods in Molecular Biology (Clifton, N.J.). 1073: 177-90. PMID 23996448 DOI: 10.1007/978-1-62703-625-2_15 |
0.431 |
|
| 2013 |
Royle K, Kontoravdi C. A systems biology approach to optimising hosts for industrial protein production. Biotechnology Letters. 35: 1961-9. PMID 23892981 DOI: 10.1007/S10529-013-1297-0 |
0.397 |
|
| 2013 |
Royle KE, Jimenez del Val I, Kontoravdi C. Integration of models and experimentation to optimise the production of potential biotherapeutics. Drug Discovery Today. 18: 1250-5. PMID 23850703 DOI: 10.1016/J.Drudis.2013.07.002 |
0.445 |
|
| 2013 |
Kyriakopoulos S, Kontoravdi C. Analysis of the landscape of biologically-derived pharmaceuticals in Europe: dominant production systems, molecule types on the rise and approval trends. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 48: 428-41. PMID 23262060 DOI: 10.1016/J.Ejps.2012.11.016 |
0.371 |
|
| 2013 |
Sou SN, Polizzi KM, Kontoravdi C. Evaluation of transfection methods for transient gene expression in Chinese hamster ovary cells Advances in Bioscience and Biotechnology. 4: 1013-1019. DOI: 10.4236/Abb.2013.412135 |
0.326 |
|
| 2013 |
Jedrzejewski PMJ, del Val IJ, Polizzi KM, Kontoravdi C. Applying quality by design to glycoprotein therapeutics: experimental and computational efforts of process control Pharmaceutical Bioprocessing. 1: 51-69. DOI: 10.4155/Pbp.13.4 |
0.387 |
|
| 2013 |
Kontoravdi C, Samsatli NJ, Shah N. Development and design of bio-pharmaceutical processes Current Opinion in Chemical Engineering. 2: 435-441. DOI: 10.1016/J.Coche.2013.09.007 |
0.414 |
|
| 2012 |
Behjousiar A, Kontoravdi C, Polizzi KM. In situ monitoring of intracellular glucose and glutamine in CHO cell culture. Plos One. 7: e34512. PMID 22509313 DOI: 10.1371/Journal.Pone.0034512 |
0.45 |
|
| 2012 |
Chen N, Koumpouras GC, Polizzi KM, Kontoravdi C. Genome-based kinetic modeling of cytosolic glucose metabolism in industrially relevant cell lines: Saccharomyces cerevisiae and Chinese hamster ovary cells. Bioprocess and Biosystems Engineering. 35: 1023-33. PMID 22286123 DOI: 10.1007/S00449-012-0687-3 |
0.419 |
|
| 2012 |
Chen N, del Val IJ, Kyriakopoulos S, Polizzi KM, Kontoravdi C. Metabolic network reconstruction: advances in in silico interpretation of analytical information. Current Opinion in Biotechnology. 23: 77-82. PMID 22119273 DOI: 10.1016/J.Copbio.2011.10.015 |
0.322 |
|
| 2012 |
Koumpouras G, Kontoravdi C. Dynamic Optimization of Bioprocesses Applied Mathematics-a Journal of Chinese Universities Series B. 3: 1487-1495. DOI: 10.4236/Am.2012.330208 |
0.472 |
|
| 2011 |
Jiménez Del Val I, Nagy JM, Kontoravdi C. Quantification of intracellular nucleotide sugars and formulation of a mathematical model for prediction of their metabolism. Bmc Proceedings. 5: P10. PMID 22373482 DOI: 10.1186/1753-6561-5-S8-P10 |
0.492 |
|
| 2011 |
Jimenez del Val I, Nagy JM, Kontoravdi C. A dynamic mathematical model for monoclonal antibody N-linked glycosylation and nucleotide sugar donor transport within a maturing Golgi apparatus. Biotechnology Progress. 27: 1730-43. PMID 21956887 DOI: 10.1002/Btpr.688 |
0.435 |
|
| 2011 |
Kiparissides A, Koutinas M, Kontoravdi C, Mantalaris A, Pistikopoulos EN. 'Closing the loop' in biological systems modeling - From the in silico to the in vitro Automatica. 47: 1147-1155. DOI: 10.1016/J.Automatica.2011.01.013 |
0.687 |
|
| 2010 |
del Val IJ, Kontoravdi C, Nagy JM. Towards the implementation of quality by design to the production of therapeutic monoclonal antibodies with desired glycosylation patterns. Biotechnology Progress. 26: 1505-27. PMID 20665659 DOI: 10.1002/Btpr.470 |
0.381 |
|
| 2010 |
Kontoravdi C, Pistikopoulos EN, Mantalaris A. Systematic development of predictive mathematical models for animal cell cultures Computers and Chemical Engineering. 34: 1192-1198. DOI: 10.1016/J.Compchemeng.2010.03.012 |
0.695 |
|
| 2008 |
Lam CM, Sriyudthsak K, Kontoravdi C, Kothari K, Park H, Pistikopoulos EN, Mantalaris A. Cell cycle modelling for off-line dynamic optimisation of mammalian cultures Computer-Aided Chemical Engineering. 25: 109-114. DOI: 10.1016/S1570-7946(08)80023-5 |
0.69 |
|
| 2007 |
Kontoravdi C, Wong D, Lam C, Lee YY, Yap MG, Pistikopoulos EN, Mantalaris A. Modeling amino acid metabolism in mammalian cells-toward the development of a model library. Biotechnology Progress. 23: 1261-9. PMID 17949105 DOI: 10.1021/Bp070106Z |
0.688 |
|
| 2007 |
Kontoravdi C, Asprey SP, Pistikopoulos EN, Mantalaris A. Development of a dynamic model of monoclonal antibody production and glycosylation for product quality monitoring Computers & Chemical Engineering. 31: 392-400. DOI: 10.1016/J.Compchemeng.2006.04.009 |
0.691 |
|
| 2005 |
Kontoravdi C, Asprey SP, Pistikopoulos EN, Mantalaris A. Application of global sensitivity analysis to determine goals for design of experiments: an example study on antibody-producing cell cultures. Biotechnology Progress. 21: 1128-35. PMID 16080692 DOI: 10.1021/Bp050028K |
0.658 |
|
| 2005 |
Kontoravdi C, Asprey SP, Pistikopoulos S, Mantalaris A. Dynamic model of MAb production and glycosylation for the purpose of product quality control Computer-Aided Chemical Engineering. 20: 307-312. DOI: 10.1016/S1570-7946(05)80173-7 |
0.653 |
|
| 2004 |
Kontoravdi C, Mantaiaris A, Pistikopoulos EN, Asprey SP, Katsika A, Gavrielides Y. Towards the Optimisation of the Production of Monoclonal Antibodies Ifac Proceedings Volumes. 37: 213-218. DOI: 10.1016/S1474-6670(17)32585-5 |
0.61 |
|
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