Olivia M Merkel - Publications

LMU Munich, Germany, München, Bayern, Germany 
Drug and Gene Delivery

42 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Merkel OM, Marsh LM, Garn H, Kissel T. Flow Cytometry-Based Cell Type-Specific Assessment of Target Regulation by Pulmonary siRNA Delivery. Methods in Molecular Biology (Clifton, N.J.). 1943: 365-375. PMID 30838629 DOI: 10.1007/978-1-4939-9092-4_24  1
2016 Zhong Q, Merkel OM, Reineke JJ, da Rocha SR. The Effect of the Route of Administration and PEGylation of Poly(amidoamine) Dendrimers on their Systemic and Lung Cellular Biodistribution. Molecular Pharmaceutics. PMID 27148629 DOI: 10.1021/Acs.Molpharmaceut.6B00036  0.48
2016 Xie Y, Kim NH, Nadithe V, Schalk D, Thakur A, Kılıç A, Lum LG, Bassett DJ, Merkel OM. Targeted delivery of siRNA to activated T Cells via transferrin-polyethylenimine (Tf-PEI) as a potential therapy of asthma. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 27001893 DOI: 10.1016/J.Jconrel.2016.03.029  0.48
2016 Jones S, Merkel O. Indium-Labeling of siRNA for Small Animal SPECT Imaging. Methods in Molecular Biology (Clifton, N.J.). 1372: 79-88. PMID 26530916 DOI: 10.1007/978-1-4939-3148-4_6  0.48
2015 Liu L, Zheng M, Librizzi D, Renette T, Merkel O, Kissel T. Efficient and tumor targeted siRNA delivery mediated by polyethylenimine-graft-polycaprolactone-block-poly (ethylene glycol)-folate (PEI- PCL-PEG-Fol). Molecular Pharmaceutics. PMID 26641134 DOI: 10.1021/Acs.Molpharmaceut.5B00575  0.48
2015 Jones SK, Lizzio V, Merkel O. Folate Receptor Targeted Delivery of siRNA and Paclitaxel to Ovarian Cancer Cells via Folate Conjugated Triblock Co-polymer to Overcome TLR4 Driven Chemotherapy Resistance. Biomacromolecules. PMID 26636884 DOI: 10.1021/Acs.Biomac.5B01189  0.48
2015 Abebe DG, Kandil R, Kraus T, Elsayed M, Merkel OM, Fujiwara T. Three-Layered Biodegradable Micelles Prepared by Two-Step Self-Assembly of PLA-PEI-PLA and PLA-PEG-PLA Triblock Copolymers as Efficient Gene Delivery System. Macromolecular Bioscience. 15: 698-711. PMID 25644720 DOI: 10.1002/Mabi.201400488  0.48
2015 Nadithe V, Liu R, Killinger BA, Movassaghian S, Kim NH, Moszczynska AB, Masters KS, Gellman SH, Merkel OM. Screening nylon-3 polymers, a new class of cationic amphiphiles, for siRNA delivery. Molecular Pharmaceutics. 12: 362-74. PMID 25437915 DOI: 10.1021/Mp5004724  0.48
2014 Merkel OM, Kissel T. Quo vadis polyplex? Journal of Controlled Release : Official Journal of the Controlled Release Society. 190: 415-23. PMID 24933599 DOI: 10.1016/J.Jconrel.2014.06.009  1
2014 Merkel OM, Rubinstein I, Kissel T. siRNA delivery to the lung: what's new? Advanced Drug Delivery Reviews. 75: 112-28. PMID 24907426 DOI: 10.1016/J.Addr.2014.05.018  0.48
2014 Endres T, Zheng M, Kılıç A, Turowska A, Beck-Broichsitter M, Renz H, Merkel OM, Kissel T. Amphiphilic biodegradable PEG-PCL-PEI triblock copolymers for FRET-capable in vitro and in vivo delivery of siRNA and quantum dots. Molecular Pharmaceutics. 11: 1273-81. PMID 24592902 DOI: 10.1021/Mp400744A  1
2014 Elsayed M, Merkel OM. Nanoimprinting of topographical and 3D cell culture scaffolds. Nanomedicine (London, England). 9: 349-66. PMID 24552565 DOI: 10.2217/Nnm.13.200  0.48
2014 Elsayed M, Corrand V, Kolhatkar V, Xie Y, Kim NH, Kolhatkar R, Merkel OM. Influence of oligospermines architecture on their suitability for siRNA delivery. Biomacromolecules. 15: 1299-310. PMID 24552396 DOI: 10.1021/Bm401849D  0.48
2013 Turowska A, Librizzi D, Baumgartl N, Kuhlmann J, Dicke T, Merkel O, Homburg U, Höffken H, Renz H, Garn H. Biodistribution of the GATA-3-specific DNAzyme hgd40 after inhalative exposure in mice, rats and dogs. Toxicology and Applied Pharmacology. 272: 365-72. PMID 23820074 DOI: 10.1016/J.Taap.2013.06.020  0.48
2013 Merkel OM, Marsh LM, Garn H, Kissel T. Flow cytometry-based cell type-specific assessment of target regulation by pulmonary siRNA delivery. Methods in Molecular Biology (Clifton, N.J.). 948: 263-73. PMID 23070776 DOI: 10.1007/978-1-62703-140-0_18  1
2012 Zheng M, Pavan GM, Neeb M, Schaper AK, Danani A, Klebe G, Merkel OM, Kissel T. Targeting the blind spot of polycationic nanocarrier-based siRNA delivery. Acs Nano. 6: 9447-54. PMID 23036046 DOI: 10.1021/Nn301966R  1
2012 Zheng M, Librizzi D, Kılıç A, Liu Y, Renz H, Merkel OM, Kissel T. Enhancing in vivo circulation and siRNA delivery with biodegradable polyethylenimine-graft-polycaprolactone-block-poly(ethylene glycol) copolymers. Biomaterials. 33: 6551-8. PMID 22710127 DOI: 10.1016/J.Biomaterials.2012.05.055  1
2012 Renette T, Librizzi D, Endres T, Merkel O, Beck-Broichsitter M, Bege N, Petersen H, Curdy C, Kissel T. Poly(ethylene carbonate) nanoparticles as carrier system for chemotherapy showing prolonged in vivo circulation and anti-tumor efficacy. Macromolecular Bioscience. 12: 970-8. PMID 22648959 DOI: 10.1002/Mabi.201100499  1
2012 Beck-Broichsitter M, Merkel OM, Kissel T. Controlled pulmonary drug and gene delivery using polymeric nano-carriers. Journal of Controlled Release : Official Journal of the Controlled Release Society. 161: 214-24. PMID 22192571 DOI: 10.1016/J.Jconrel.2011.12.004  1
2012 Merkel OM, Zheng M, Debus H, Kissel T. Pulmonary gene delivery using polymeric nonviral vectors. Bioconjugate Chemistry. 23: 3-20. PMID 21999216 DOI: 10.1021/Bc200296Q  1
2012 Weber ND, Merkel OM, Kissel T, Muñoz-Fernández MÁ. PEGylated poly(ethylene imine) copolymer-delivered siRNA inhibits HIV replication in vitro. Journal of Controlled Release : Official Journal of the Controlled Release Society. 157: 55-63. PMID 21930169 DOI: 10.1016/J.Jconrel.2011.09.059  1
2012 Merkel OM, Kissel T. Nonviral pulmonary delivery of siRNA. Accounts of Chemical Research. 45: 961-70. PMID 21905687 DOI: 10.1021/Ar200110P  1
2012 Zheng M, Liu Y, Samsonova O, Endres T, Merkel O, Kissel T. Amphiphilic and biodegradable hy-PEI-g-PCL-b-PEG copolymers efficiently mediate transgene expression depending on their graft density. International Journal of Pharmaceutics. 427: 80-7. PMID 21600970 DOI: 10.1016/J.Ijpharm.2011.05.017  1
2011 Liu Y, Samsonova O, Sproat B, Merkel O, Kissel T. Biophysical characterization of hyper-branched polyethylenimine-graft-polycaprolactone-block-mono-methoxyl-poly(ethylene glycol) copolymers (hy-PEI-PCL-mPEG) for siRNA delivery. Journal of Controlled Release : Official Journal of the Controlled Release Society. 153: 262-8. PMID 21549166 DOI: 10.1016/J.Jconrel.2011.04.017  1
2011 Bege N, Renette T, Jansch M, Reul R, Merkel O, Petersen H, Curdy C, Müller RH, Kissel T. Biodegradable poly(ethylene carbonate) nanoparticles as a promising drug delivery system with "stealth" potential. Macromolecular Bioscience. 11: 897-904. PMID 21472988 DOI: 10.1002/Mabi.201000496  1
2011 Merkel OM, Urbanics R, Bedocs P, Rozsnyay Z, Rosivall L, Toth M, Kissel T, Szebeni J. In vitro and in vivo complement activation and related anaphylactic effects associated with polyethylenimine and polyethylenimine-graft-poly(ethylene glycol) block copolymers. Biomaterials. 32: 4936-42. PMID 21459440 DOI: 10.1016/J.Biomaterials.2011.03.035  0.48
2011 Merkel OM, Zheng M, Mintzer MA, Pavan GM, Librizzi D, Maly M, Höffken H, Danani A, Simanek EE, Kissel T. Molecular modeling and in vivo imaging can identify successful flexible triazine dendrimer-based siRNA delivery systems. Journal of Controlled Release : Official Journal of the Controlled Release Society. 153: 23-33. PMID 21342661 DOI: 10.1016/J.Jconrel.2011.02.016  1
2011 Beyerle A, Braun A, Merkel O, Koch F, Kissel T, Stoeger T. Comparative in vivo study of poly(ethylene imine)/siRNA complexes for pulmonary delivery in mice. Journal of Controlled Release : Official Journal of the Controlled Release Society. 151: 51-6. PMID 21223987 DOI: 10.1016/J.Jconrel.2010.12.017  1
2011 Merkel OM, Beyerle A, Beckmann BM, Zheng M, Hartmann RK, Stöger T, Kissel TH. Polymer-related off-target effects in non-viral siRNA delivery. Biomaterials. 32: 2388-98. PMID 21183213 DOI: 10.1016/J.Biomaterials.2010.11.081  0.56
2010 Merkel OM, Mintzer MA, Simanek EE, Kissel T. Perfectly shaped siRNA delivery. Therapeutic Delivery. 1: 737-42. PMID 22834010 DOI: 10.4155/Tde.10.69  1
2010 Merkel OM, Mintzer MA, Librizzi D, Samsonova O, Dicke T, Sproat B, Garn H, Barth PJ, Simanek EE, Kissel T. Triazine dendrimers as nonviral vectors for in vitro and in vivo RNAi: the effects of peripheral groups and core structure on biological activity. Molecular Pharmaceutics. 7: 969-83. PMID 20524664 DOI: 10.1021/Mp100101S  0.48
2010 Pavan GM, Mintzer MA, Simanek EE, Merkel OM, Kissel T, Danani A. Computational insights into the interactions between DNA and siRNA with "rigid" and "flexible" triazine dendrimers. Biomacromolecules. 11: 721-30. PMID 20131771 DOI: 10.1021/Bm901298T  1
2010 Beyerle A, Merkel O, Stoeger T, Kissel T. PEGylation affects cytotoxicity and cell-compatibility of poly(ethylene imine) for lung application: structure-function relationships. Toxicology and Applied Pharmacology. 242: 146-54. PMID 19822165 DOI: 10.1016/J.Taap.2009.10.001  1
2009 Mintzer MA, Merkel OM, Kissel T, Simanek EE. Polycationic triazine-based dendrimers: effect of peripheral groups on transfection efficiency. New Journal of Chemistry = Nouveau Journal De Chimie. 33: 1918-1925. PMID 19960102 DOI: 10.1039/B908735D  1
2009 Merkel OM, Mintzer MA, Sitterberg J, Bakowsky U, Simanek EE, Kissel T. Triazine dendrimers as nonviral gene delivery systems: effects of molecular structure on biological activity. Bioconjugate Chemistry. 20: 1799-806. PMID 19708683 DOI: 10.1021/Bc900243R  1
2009 Merkel OM, Beyerle A, Librizzi D, Pfestroff A, Behr TM, Sproat B, Barth PJ, Kissel T. Nonviral siRNA delivery to the lung: investigation of PEG-PEI polyplexes and their in vivo performance. Molecular Pharmaceutics. 6: 1246-60. PMID 19606864 DOI: 10.1021/Mp900107V  0.48
2009 Merkel OM, Germershaus O, Wada CK, Tarcha PJ, Merdan T, Kissel T. Integrin alphaVbeta3 targeted gene delivery using RGD peptidomimetic conjugates with copolymers of PEGylated poly(ethylene imine). Bioconjugate Chemistry. 20: 1270-80. PMID 19476331 DOI: 10.1021/Bc9001695  1
2009 Merkel OM, Librizzi D, Pfestroff A, Schurrat T, Buyens K, Sanders NN, De Smedt SC, Béhé M, Kissel T. Stability of siRNA polyplexes from poly(ethylenimine) and poly(ethylenimine)-g-poly(ethylene glycol) under in vivo conditions: effects on pharmacokinetics and biodistribution measured by Fluorescence Fluctuation Spectroscopy and Single Photon Emission Computed Tomography (SPECT) imaging. Journal of Controlled Release : Official Journal of the Controlled Release Society. 138: 148-59. PMID 19463870 DOI: 10.1016/J.Jconrel.2009.05.016  1
2009 Malek A, Merkel O, Fink L, Czubayko F, Kissel T, Aigner A. In vivo pharmacokinetics, tissue distribution and underlying mechanisms of various PEI(-PEG)/siRNA complexes. Toxicology and Applied Pharmacology. 236: 97-108. PMID 19371615 DOI: 10.1016/J.Taap.2009.01.014  1
2009 Merkel OM, Librizzi D, Pfestroff A, Schurrat T, Béhé M, Kissel T. In vivo SPECT and real-time gamma camera imaging of biodistribution and pharmacokinetics of siRNA delivery using an optimized radiolabeling and purification procedure. Bioconjugate Chemistry. 20: 174-82. PMID 19093855 DOI: 10.1021/Bc800408G  1
2008 Nguyen J, Steele TW, Merkel O, Reul R, Kissel T. Fast degrading polyesters as siRNA nano-carriers for pulmonary gene therapy. Journal of Controlled Release : Official Journal of the Controlled Release Society. 132: 243-51. PMID 18619502 DOI: 10.1016/J.Jconrel.2008.06.010  1
2006 Mao S, Neu M, Germershaus O, Merkel O, Sitterberg J, Bakowsky U, Kissel T. Influence of polyethylene glycol chain length on the physicochemical and biological properties of poly(ethylene imine)-graft-poly(ethylene glycol) block copolymer/SiRNA polyplexes. Bioconjugate Chemistry. 17: 1209-18. PMID 16984130 DOI: 10.1021/Bc060129J  1
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