Ian J. MacRae, Ph.D. - Publications

Integrative Structural and Computational Biology Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Structural Biology

29 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Wu MK, de Kock L, Conwell LS, Stewart C, King BR, Choong C, Hussain K, Sabbaghian N, MacRae IJ, Fabian MR, Foulkes W. Functional characterization of multiple DICER1 mutations in an adolescent. Endocrine-Related Cancer. PMID 26545620 DOI: 10.1530/ERC-15-0460  0.44
2015 Schirle NT, Sheu-Gruttadauria J, Chandradoss SD, Joo C, MacRae IJ. Water-mediated recognition of t1-adenosine anchors Argonaute2 to microRNA targets. Elife. 4. PMID 26359634 DOI: 10.7554/eLife.07646  0.44
2015 Chandradoss SD, Schirle NT, Szczepaniak M, MacRae IJ, Joo C. A Dynamic Search Process Underlies MicroRNA Targeting. Cell. 162: 96-107. PMID 26140593 DOI: 10.1016/j.cell.2015.06.032  0.44
2013 Xiong XP, Kurthkoti K, Chang KY, Lichinchi G, De N, Schneemann A, MacRae IJ, Rana TM, Perrimon N, Zhou R. Core small nuclear ribonucleoprotein particle splicing factor SmD1 modulates RNA interference in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. 110: 16520-5. PMID 24067655 DOI: 10.1073/pnas.1315803110  0.44
2013 Horman SR, Janas MM, Litterst C, Wang B, MacRae IJ, Sever MJ, Morrissey DV, Graves P, Luo B, Umesalma S, Qi HH, Miraglia LJ, Novina CD, Orth AP. Akt-mediated phosphorylation of argonaute 2 downregulates cleavage and upregulates translational repression of MicroRNA targets. Molecular Cell. 50: 356-67. PMID 23603119 DOI: 10.1016/j.molcel.2013.03.015  0.44
2012 Bale S, Julien JP, Bornholdt ZA, Kimberlin CR, Halfmann P, Zandonatti MA, Kunert J, Kroon GJ, Kawaoka Y, MacRae IJ, Wilson IA, Saphire EO. Marburg virus VP35 can both fully coat the backbone and cap the ends of dsRNA for interferon antagonism. Plos Pathogens. 8: e1002916. PMID 23028316 DOI: 10.1371/journal.ppat.1002916  0.44
2012 Pratt AJ, Rambo RP, Lau PW, MacRae IJ. Preparation and characterization of the extracellular domain of human Sid-1. Plos One. 7: e33607. PMID 22509261 DOI: 10.1371/journal.pone.0033607  0.44
2012 Guiley KZ, Pratt AJ, MacRae IJ. Single-pot enzymatic synthesis of Dicer-substrate siRNAs. Nucleic Acids Research. 40: e40. PMID 22189103 DOI: 10.1093/nar/gkr1174  0.44
2011 Hastie KM, Kimberlin CR, Zandonatti MA, MacRae IJ, Saphire EO. Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3' to 5' exonuclease activity essential for immune suppression. Proceedings of the National Academy of Sciences of the United States of America. 108: 2396-401. PMID 21262835 DOI: 10.1073/pnas.1016404108  0.44
2010 Kimberlin CR, Bornholdt ZA, Li S, Woods VL, MacRae IJ, Saphire EO. Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression. Proceedings of the National Academy of Sciences of the United States of America. 107: 314-9. PMID 20018665 DOI: 10.1073/pnas.0910547107  0.44
2009 Pratt AJ, MacRae IJ. The RNA-induced silencing complex: a versatile gene-silencing machine. The Journal of Biological Chemistry. 284: 17897-901. PMID 19342379 DOI: 10.1074/jbc.R900012200  0.44
2008 Ma E, MacRae IJ, Kirsch JF, Doudna JA. Autoinhibition of human dicer by its internal helicase domain. Journal of Molecular Biology. 380: 237-43. PMID 18508075 DOI: 10.1016/j.jmb.2008.05.005  0.48
2008 MacRae IJ, Ma E, Zhou M, Robinson CV, Doudna JA. In vitro reconstitution of the human RISC-loading complex. Proceedings of the National Academy of Sciences of the United States of America. 105: 512-7. PMID 18178619 DOI: 10.1073/pnas.0710869105  0.48
2007 MacRae IJ, Zhou K, Doudna JA. Structural determinants of RNA recognition and cleavage by Dicer. Nature Structural & Molecular Biology. 14: 934-40. PMID 17873886 DOI: 10.1038/nsmb1293  0.48
2007 MacRae IJ, Doudna JA. An unusual case of pseudo-merohedral twinning in orthorhombic crystals of Dicer. Acta Crystallographica. Section D, Biological Crystallography. 63: 993-9. PMID 17704568 DOI: 10.1107/S0907444907036128  0.48
2007 MacRae IJ, Doudna JA. Ribonuclease revisited: structural insights into ribonuclease III family enzymes. Current Opinion in Structural Biology. 17: 138-45. PMID 17194582 DOI: 10.1016/j.sbi.2006.12.002  0.48
2006 Macrae IJ, Li F, Zhou K, Cande WZ, Doudna JA. Structure of Dicer and mechanistic implications for RNAi. Cold Spring Harbor Symposia On Quantitative Biology. 71: 73-80. PMID 17381283 DOI: 10.1101/sqb.2006.71.042  0.48
2006 Macrae IJ, Zhou K, Li F, Repic A, Brooks AN, Cande WZ, Adams PD, Doudna JA. Structural basis for double-stranded RNA processing by Dicer. Science (New York, N.Y.). 311: 195-8. PMID 16410517 DOI: 10.1126/science.1121638  0.44
2005 Macrae IJ, Doudna JA. Ro's role in RNA reconnaissance. Cell. 121: 495-6. PMID 15907458 DOI: 10.1016/j.cell.2005.05.004  0.48
2004 Hanna E, Ng KF, MacRae IJ, Bley CJ, Fisher AJ, Segel IH. Kinetic and stability properties of Penicillium chrysogenum ATP sulfurylase missing the C-terminal regulatory domain. The Journal of Biological Chemistry. 279: 4415-24. PMID 14613928 DOI: 10.1074/jbc.M311317200  0.44
2002 MacRae IJ, Segel IH, Fisher AJ. Allosteric inhibition via R-state destabilization in ATP sulfurylase from Penicillium chrysogenum. Nature Structural Biology. 9: 945-9. PMID 12426581 DOI: 10.1038/nsb868  0.44
2002 Hanna E, MacRae IJ, Medina DC, Fisher AJ, Segel IH. ATP sulfurylase from the hyperthermophilic chemolithotroph Aquifex aeolicus. Archives of Biochemistry and Biophysics. 406: 275-88. PMID 12361716 DOI: 10.1016/S0003-9861(02)00428-9  0.44
2001 Beynon JD, MacRae IJ, Huston SL, Nelson DC, Segel IH, Fisher AJ. Crystal structure of ATP sulfurylase from the bacterial symbiont of the hydrothermal vent tubeworm Riftia pachyptila. Biochemistry. 40: 14509-17. PMID 11724564 DOI: 10.1021/bi015643l  0.44
2001 Medina DC, Hanna E, MacRae IJ, Fisher AJ, Segel IH. Temperature effects on the allosteric transition of ATP sulfurylase from Penicillium chrysogenum. Archives of Biochemistry and Biophysics. 393: 51-60. PMID 11516160 DOI: 10.1006/abbi.2001.2490  0.44
2001 MacRae IJ, Segel IH, Fisher AJ. Crystal structure of ATP sulfurylase from Penicillium chrysogenum: insights into the allosteric regulation of sulfate assimilation. Biochemistry. 40: 6795-804. PMID 11389593 DOI: 10.1021/bi010367w  0.44
2000 MacRae IJ, Hanna E, Ho JD, Fisher AJ, Segel IH. Induction of positive cooperativity by amino acid replacements within the C-terminal domain of Penicillium chrysogenum ATP sulfurylase. The Journal of Biological Chemistry. 275: 36303-10. PMID 10956658 DOI: 10.1074/jbc.M005992200  0.44
2000 MacRae IJ, Segel IH, Fisher AJ. Crystal structure of adenosine 5'-phosphosulfate kinase from Penicillium chrysogenum. Biochemistry. 39: 1613-21. PMID 10677210 DOI: 10.1021/bi9924157  0.44
1999 MacRae IJ, Segel IH. Adenosine 5'-phosphosulfate (APS) kinase: diagnosing the mechanism of substrate inhibition. Archives of Biochemistry and Biophysics. 361: 277-82. PMID 9882457 DOI: 10.1006/abbi.1998.0993  0.44
1998 MacRae IJ, Rose AB, Segel IH. Adenosine 5'-phosphosulfate kinase from Penicillium chrysogenum. site-directed mutagenesis at putative phosphoryl-accepting and ATP P-loop residues. The Journal of Biological Chemistry. 273: 28583-9. PMID 9786849 DOI: 10.1074/jbc.273.44.28583  0.44
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