John Cavanagh, Ph.D. - Publications

Affiliations: 
Structural & Molecular Biochemistry North Carolina State University, Raleigh, NC 

69 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Milton ME, Draughn GL, Bobay BG, Stowe SD, Olson AL, Feldmann EA, Thompson RJ, Myers KH, Santoro MT, Kearns DB, Cavanagh J. The Solution Structures and Interaction of SinR and SinI: Elucidating the Mechanism of Action of the Master Regulator Switch for Biofilm Formation in Bacillus subtilis. Journal of Molecular Biology. PMID 31493408 DOI: 10.1016/j.jmb.2019.08.019  0.72
2018 Milton ME, Minrovic BM, Harris DL, Kang B, Jung D, Lewis CP, Thompson RJ, Melander RJ, Zeng D, Melander C, Cavanagh J. Re-sensitizing Multidrug Resistant Bacteria to Antibiotics by Targeting Bacterial Response Regulators: Characterization and Comparison of Interactions between 2-Aminoimidazoles and the Response Regulators BfmR fromand QseB fromspp. Frontiers in Molecular Biosciences. 5: 15. PMID 29487854 DOI: 10.3389/fmolb.2018.00015  0.72
2018 Logan Draughn G, Milton ME, Feldmann EA, Bobay BG, Roth BM, Olson AL, Thompson RJ, Actis LA, Davies C, Cavanagh J. The structure of the biofilm-controlling response regulator BfmR from Acinetobacter baumannii reveals details of its DNA-binding mechanism. Journal of Molecular Biology. PMID 29438671 DOI: 10.1016/j.jmb.2018.02.002  0.72
2017 Milton ME, Leigh Allen C, Feldmann EA, Bobay BG, Jung DK, Stephens MD, Melander RJ, Theisen KE, Zeng D, Thompson RJ, Melander C, Cavanagh J. Structure of the Francisella response regulator QseB receiver domain, and characterization of QseB inhibition by antibiofilm 2-aminoimidazole-based compounds. Molecular Microbiology. PMID 28755524 DOI: 10.1111/mmi.13759  0.72
2017 Draughn GL, Allen CL, Routh PA, Stone MR, Kirker KR, Boegli L, Schuchman RM, Linder KE, Baynes RE, James G, Melander C, Pollard A, Cavanagh J. Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections. Drug Design, Development and Therapy. 11: 153-162. PMID 28138218 DOI: 10.2147/DDDT.S111865  0.52
2016 Stephens MD, Hubble VB, Ernst RK, van Hoek ML, Melander RJ, Cavanagh J, Melander C. Potentiation of Francisella Resistance to Conventional Antibiotics through Small Molecule Adjuvants. Medchemcomm. 7: 128-131. PMID 26877862 DOI: 10.1039/C5MD00353A  0.52
2015 Wahome PG, Beauchesne KR, Pedone AC, Cavanagh J, Melander C, Zimba P, Moeller PD. Augmenting anti-cancer natural products with a small molecule adjuvant. Marine Drugs. 13: 65-75. PMID 25548974 DOI: 10.3390/md13010065  0.52
2015 Stowe SD, Thompson RJ, Peng L, Su Z, Blackledge MS, Draughn GL, Coe WH, Johannes E, Lapham VK, Mackenzie J, Melander C, Cavanagh J. Membrane-permeabilizing activity of reverse-amide 2-aminoimidazole antibiofilm agents against Acinetobacter baumannii. Current Drug Delivery. 12: 223-30. PMID 25348099  0.72
2015 Wahome PG, Beauchesne KR, Pedone AC, Cavanagh J, Melander C, Zimba P, Moeller PDR. Augmenting anti-cancer natural products with a small molecule adjuvant Marine Drugs. 13: 65-75. DOI: 10.3390/md13010065  0.52
2014 Olson AL, Tucker AT, Bobay BG, Soderblom EJ, Moseley MA, Thompson RJ, Cavanagh J. Structure and DNA-binding traits of the transition state regulator AbrB. Structure (London, England : 1993). 22: 1650-6. PMID 25308864 DOI: 10.1016/j.str.2014.08.018  0.72
2014 Brackett CM, Melander RJ, An IH, Krishnamurthy A, Thompson RJ, Cavanagh J, Melander C. Small-molecule suppression of β-lactam resistance in multidrug-resistant gram-negative pathogens. Journal of Medicinal Chemistry. 57: 7450-8. PMID 25137478 DOI: 10.1021/jm501050e  0.72
2014 Tucker AT, Bobay BG, Banse AV, Olson AL, Soderblom EJ, Moseley MA, Thompson RJ, Varney KM, Losick R, Cavanagh J. A DNA mimic: the structure and mechanism of action for the anti-repressor protein AbbA. Journal of Molecular Biology. 426: 1911-24. PMID 24534728 DOI: 10.1016/j.jmb.2014.02.010  0.72
2014 Bobay BG, Thompson RJ, Milton DL, Cavanagh J. Chemical shift assignments and secondary structure prediction of the phosphorelay protein VanU from Vibrio anguillarum. Biomolecular Nmr Assignments. 8: 177-9. PMID 23604692 DOI: 10.1007/s12104-013-9478-2  0.72
2014 Stowe SD, Olson AL, Losick R, Cavanagh J. Chemical shift assignments and secondary structure prediction of the master biofilm regulator, SinR, from Bacillus subtilis. Biomolecular Nmr Assignments. 8: 155-8. PMID 23475644 DOI: 10.1007/s12104-013-9473-7  0.72
2014 Olson AL, Thompson RJ, Melander C, Cavanagh J. Chemical shift assignments and secondary structure prediction of the C-terminal domain of the response regulator BfmR from Acinetobacter baumannii. Biomolecular Nmr Assignments. 8: 67-70. PMID 23264007 DOI: 10.1007/s12104-012-9454-2  0.72
2013 Olson AL, Liu F, Tucker AT, Goshe MB, Cavanagh J. Chemical crosslinking and LC/MS analysis to determine protein domain orientation: Application to AbrB Biochemical and Biophysical Research Communications. 431: 253-257. PMID 23313475 DOI: 10.1016/j.bbrc.2012.12.124  0.72
2012 Bobay BG, Hoch JA, Cavanagh J. Dynamics and activation in response regulators: the β4-α4 loop. Biomolecular Concepts. 3: 175-182. PMID 24494032 DOI: 10.1515/bmc-2011-0063  0.72
2012 Thompson RJ, Bobay BG, Stowe SD, Olson AL, Peng L, Su Z, Actis LA, Melander C, Cavanagh J. Identification of BfmR, a response regulator involved in biofilm development, as a target for a 2-Aminoimidazole-based antibiofilm agent. Biochemistry. 51: 9776-8. PMID 23186243 DOI: 10.1021/bi3015289  0.72
2012 Bobay BG, Stewart AL, Tucker AT, Thompson RJ, Varney KM, Cavanagh J. Structural insights into the calcium-dependent interaction between calbindin-D28K and caspase-3. Febs Letters. 586: 3582-9. PMID 22982862 DOI: 10.1016/j.febslet.2012.08.032  0.72
2012 Stowe SD, Tucker AT, Thompson R, Piper A, Richards JJ, Rogers SA, Mathies LD, Melander C, Cavanagh J. Evaluation of the toxicity of 2-aminoimidazole antibiofilm agents using both cellular and model organism systems. Drug and Chemical Toxicology. 35: 310-5. PMID 22292413 DOI: 10.3109/01480545.2011.614620  0.72
2012 Olson AL, Bobay BG, Melander C, Cavanagh J. 1H, 13C, and 15N resonance assignments and secondary structure prediction of the full-length transition state regulator AbrB from Bacillus anthracis Biomolecular Nmr Assignments. 6: 95-98. PMID 21845362 DOI: 10.1007/s12104-011-9333-2  0.72
2011 Bunders CA, Minvielle MJ, Worthington RJ, Ortiz M, Cavanagh J, Melander C. Intercepting bacterial indole signaling with flustramine derivatives. Journal of the American Chemical Society. 133: 20160-3. PMID 22091927 DOI: 10.1021/ja209836z  0.52
2011 Stowe SD, Richards JJ, Tucker AT, Thompson R, Melander C, Cavanagh J. Anti-biofilm compounds derived from marine sponges. Marine Drugs. 9: 2010-35. PMID 22073007 DOI: 10.3390/md9102010  0.72
2011 Bunders C, Cavanagh J, Melander C. Flustramine inspired synthesis and biological evaluation of pyrroloindoline triazole amides as novel inhibitors of bacterial biofilms. Organic & Biomolecular Chemistry. 9: 5476-81. PMID 21674109 DOI: 10.1039/c1ob05605k  0.52
2011 Refaei MA, Combs A, Kojetin DJ, Cavanagh J, Caperelli C, Rance M, Sapitro J, Tsang P. Observing selected domains in multi-domain proteins via sortase-mediated ligation and NMR spectroscopy. Journal of Biomolecular Nmr. 49: 3-7. PMID 21188472 DOI: 10.1007/s10858-010-9464-2  0.72
2010 Bobay BG, Thompson RJ, Hoch JA, Cavanagh J. Long range dynamic effects of point-mutations trap a response regulator in an active conformation. Febs Letters. 584: 4203-7. PMID 20828564 DOI: 10.1016/j.febslet.2010.08.051  0.72
2010 Hobbs CA, Bobay BG, Thompson RJ, Perego M, Cavanagh J. NMR solution structure and DNA-binding model of the DNA-binding domain of competence protein A. Journal of Molecular Biology. 398: 248-63. PMID 20302877 DOI: 10.1016/j.jmb.2010.03.003  0.72
2010 Rogers SA, Huigens RW, Cavanagh J, Melander C. Synergistic effects between conventional antibiotics and 2-aminoimidazole-derived antibiofilm agents. Antimicrobial Agents and Chemotherapy. 54: 2112-8. PMID 20211901 DOI: 10.1128/AAC.01418-09  0.52
2010 Yang H, Gurgel PV, Williams DK, Bobay BG, Cavanagh J, Muddiman DC, Carbonell RG. Binding site on human immunoglobulin G for the affinity ligand HWRGWV. Journal of Molecular Recognition : Jmr. 23: 271-82. PMID 20049844 DOI: 10.1002/jmr.967  0.72
2009 Melander C, Moeller PD, Ballard TE, Richards JJ, Huigens RW, Cavanagh J. Evaluation of dihydrooroidin as an antifouling additive in marine paint. International Biodeterioration & Biodegradation. 63: 529-532. PMID 23874076 DOI: 10.1016/j.ibiod.2008.08.009  0.52
2009 Richards JJ, Reyes S, Stowe SD, Tucker AT, Ballard TE, Mathies LD, Cavanagh J, Melander C. Amide isosteres of oroidin: assessment of antibiofilm activity and C. elegans toxicity. Journal of Medicinal Chemistry. 52: 4582-5. PMID 19719234 DOI: 10.1021/jm900378s  0.72
2009 Hobbs CA, Deterding LJ, Perera L, Bobay BG, Thompson RJ, Darden TA, Cavanagh J, Tomer KB. Structural characterization of the conformational change in calbindin-D28k upon calcium binding using differential surface modification analyzed by mass spectrometry. Biochemistry. 48: 8603-14. PMID 19658395 DOI: 10.1021/bi900350q  0.72
2009 Kojetin DJ, McLaughlin PD, Thompson RJ, Dubnau D, Prepiak P, Rance M, Cavanagh J. Structural and motional contributions of the Bacillus subtilis ClpC N-domain to adaptor protein interactions. Journal of Molecular Biology. 387: 639-52. PMID 19361434 DOI: 10.1016/j.jmb.2009.01.046  0.72
2008 Sullivan DM, Bobay BG, Kojetin DJ, Thompson RJ, Rance M, Strauch MA, Cavanagh J. Insights into the nature of DNA binding of AbrB-like transcription factors. Structure (London, England : 1993). 16: 1702-13. PMID 19000822 DOI: 10.1016/j.str.2008.08.014  0.72
2008 Szurmant H, Bobay BG, White RA, Sullivan DM, Thompson RJ, Hwa T, Hoch JA, Cavanagh J. Co-evolving motions at protein-protein interfaces of two-component signaling systems identified by covariance analysis. Biochemistry. 47: 7782-4. PMID 18588317 DOI: 10.1021/bi8009604  0.72
2008 Huigens RW, Ma L, Gambino C, Moeller PD, Basso A, Cavanagh J, Wozniak DJ, Melander C. Control of bacterial biofilms with marine alkaloid derivatives. Molecular Biosystems. 4: 614-21. PMID 18493660 DOI: 10.1039/b719989a  0.72
2008 Richards JJ, Huigens Iii RW, Ballard TE, Basso A, Cavanagh J, Melander C. Inhibition and dispersion of proteobacterial biofilms. Chemical Communications (Cambridge, England). 1698-700. PMID 18368169 DOI: 10.1039/b719802g  0.52
2008 Burns VA, Bobay BG, Basso A, Cavanagh J, Melander C. Targeting RNA with cysteine-constrained peptides. Bioorganic & Medicinal Chemistry Letters. 18: 565-7. PMID 18065222 DOI: 10.1016/j.bmcl.2007.11.096  0.68
2007 Kojetin DJ, McLaughlin PD, Thompson RJ, Venters RA, Rance M, Cavanagh J. NMR assignment of the N-terminal repeat domain of Bacillus subtilis ClpC. Biomolecular Nmr Assignments. 1: 163-5. PMID 19636855 DOI: 10.1007/s12104-007-9046-8  0.72
2007 Soderblom EJ, Bobay BG, Cavanagh J, Goshe MB. Tandem mass spectrometry acquisition approaches to enhance identification of protein-protein interactions using low-energy collision-induced dissociative chemical crosslinking reagents. Rapid Communications in Mass Spectrometry : Rcm. 21: 3395-408. PMID 17902198 DOI: 10.1002/rcm.3213  0.72
2007 Kordys DR, Bobay BG, Thompson RJ, Venters RA, Cavanagh J. Peptide binding proclivities of calcium loaded calbindin-D28k. Febs Letters. 581: 4778-82. PMID 17880944 DOI: 10.1016/j.febslet.2007.09.004  0.72
2007 Strauch MA, Bobay BG, Cavanagh J, Yao F, Wilson A, Le Breton Y. Abh and AbrB control of Bacillus subtilis antimicrobial gene expression. Journal of Bacteriology. 189: 7720-32. PMID 17720793 DOI: 10.1128/JB.01081-07  0.68
2007 Kojetin DJ, Sullivan DM, Thompson RJ, Cavanagh J. Classification of response regulators based on their surface properties. Methods in Enzymology. 422: 141-69. PMID 17628138 DOI: 10.1016/S0076-6879(06)22007-X  0.72
2007 McLaughlin PD, Bobay BG, Regel EJ, Thompson RJ, Hoch JA, Cavanagh J. Predominantly buried residues in the response regulator Spo0F influence specific sensor kinase recognition. Febs Letters. 581: 1425-9. PMID 17350627 DOI: 10.1016/j.febslet.2007.02.061  0.72
2006 Kojetin DJ, Venters RA, Kordys DR, Thompson RJ, Kumar R, Cavanagh J. Structure, binding interface and hydrophobic transitions of Ca2+-loaded calbindin-D(28K). Nature Structural & Molecular Biology. 13: 641-7. PMID 16799559 DOI: 10.1038/nsmb1112  0.72
2006 Bobay BG, Mueller GA, Thompson RJ, Murzin AG, Venters RA, Strauch MA, Cavanagh J. NMR structure of AbhN and comparison with AbrBN: FIRST insights into the DNA binding promiscuity and specificity of AbrB-like transition state regulator proteins. The Journal of Biological Chemistry. 281: 21399-409. PMID 16702211 DOI: 10.1074/jbc.M601963200  0.72
2006 Sharp JS, Sullivan DM, Cavanagh J, Tomer KB. Measurement of multisite oxidation kinetics reveals an active site conformational change in Spo0F as a result of protein oxidation. Biochemistry. 45: 6260-6. PMID 16700537 DOI: 10.1021/bi060470r  0.72
2005 Kojetin DJ, Thompson RJ, Benson LM, Naylor S, Waterman J, Davies KG, Opperman CH, Stephenson K, Hoch JA, Cavanagh J. Structural analysis of divalent metals binding to the Bacillus subtilis response regulator Spo0F: the possibility for in vitro metalloregulation in the initiation of sporulation. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. 18: 449-66. PMID 16333746 DOI: 10.1007/s10534-005-4303-8  0.72
2005 Bobay BG, Andreeva A, Mueller GA, Cavanagh J, Murzin AG. Revised structure of the AbrB N-terminal domain unifies a diverse superfamily of putative DNA-binding proteins. Febs Letters. 579: 5669-74. PMID 16223496 DOI: 10.1016/j.febslet.2005.09.045  0.68
2005 Venters RA, Coggins BE, Kojetin D, Cavanagh J, Zhou P. (4,2)D Projection--reconstruction experiments for protein backbone assignment: application to human carbonic anhydrase II and calbindin D(28K). Journal of the American Chemical Society. 127: 8785-95. PMID 15954785 DOI: 10.1021/ja0509580  0.72
2005 Ulrich DL, Kojetin D, Bassler BL, Cavanagh J, Loria JP. Solution structure and dynamics of LuxU from Vibrio harveyi, a phosphotransferase protein involved in bacterial quorum sensing. Journal of Molecular Biology. 347: 297-307. PMID 15740742 DOI: 10.1016/j.jmb.2005.01.039  0.72
2004 Bobay BG, Benson L, Naylor S, Feeney B, Clark AC, Goshe MB, Strauch MA, Thompson R, Cavanagh J. Evaluation of the DNA binding tendencies of the transition state regulator AbrB. Biochemistry. 43: 16106-18. PMID 15610005 DOI: 10.1021/bi048399h  0.72
2004 Ulrich DL, Thompson R, Bassler B, Cavanagh J, Loria JP. 1H, 15N, and 13C chemical shift assignments of the Vibrio harveyi histidine phosphotransferase protein LuxU. Journal of Biomolecular Nmr. 29: 551-2. PMID 15243194 DOI: 10.1023/B:JNMR.0000034349.22942.e1  0.72
2003 Kojetin DJ, Thompson RJ, Cavanagh J. Sub-classification of response regulators using the surface characteristics of their receiver domains. Febs Letters. 554: 231-6. PMID 14623071 DOI: 10.1016/S0014-5793(03)01167-0  0.72
2003 Cavanagh J, Benson LM, Thompson R, Naylor S. In line desalting mass spectrometry for the study of noncovalent biological complexes. Analytical Chemistry. 75: 3281-6. PMID 14570174  0.52
2003 Venters RA, Benson LM, Craig TA, Bagu J, Paul KH, Kordys DR, Thompson R, Naylor S, Kumar R, Cavanagh J. The effects of Ca(2+) binding on the conformation of calbindin D(28K): a nuclear magnetic resonance and microelectrospray mass spectrometry study. Analytical Biochemistry. 317: 59-66. PMID 12729601 DOI: 10.1016/S0003-2697(03)00084-8  0.72
2003 Lutz W, Frank EM, Craig TA, Thompson R, Venters RA, Kojetin D, Cavanagh J, Kumar R. Calbindin D28K interacts with Ran-binding protein M: identification of interacting domains by NMR spectroscopy. Biochemical and Biophysical Research Communications. 303: 1186-92. PMID 12684061  0.56
2003 Benson LM, Kumar R, Cavanagh J, Naylor S. Protein-metal ion interactions, stoichiometries and relative affinities determined by on-line size exclusion gel filtration mass spectrometry. Rapid Communications in Mass Spectrometry : Rcm. 17: 267-71. PMID 12569434 DOI: 10.1002/rcm.903  0.4
2002 Helton TD, Kojetin DJ, Cavanagh J, Horne WA. Alternative splicing of a beta4 subunit proline-rich motif regulates voltage-dependent gating and toxin block of Cav2.1 Ca2+ channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 9331-9. PMID 12417658  0.72
2002 Sehgal AC, Tompson R, Cavanagh J, Kelly RM. Structural and catalytic response to temperature and cosolvents of carboxylesterase EST1 from the extremely thermoacidophilic archaeon Sulfolobus solfataricus P1. Biotechnology and Bioengineering. 80: 784-93. PMID 12402324 DOI: 10.1002/bit.10433  0.72
2002 Benson LM, Vaughn JL, Strauch MA, Bobay BG, Thompson R, Naylor S, Cavanagh J. Macromolecular assembly of the transition state regulator AbrB in its unbound and complexed states probed by microelectrospray ionization mass spectrometry. Analytical Biochemistry. 306: 222-7. PMID 12123659 DOI: 10.1006/abio.2002.5704  0.72
2002 Cavanagh J, Thompson R, Bobay B, Benson LM, Naylor S. Stoichiometries of protein-protein/DNA binding and conformational changes for the transition-state regulator AbrB measured by pseudo cell-size exclusion chromatography-mass spectrometry. Biochemistry. 41: 7859-65. PMID 12069574  0.52
2000 Cipollo JF, Trimble RB, Rance M, Cavanagh J. Two-dimensional relayed-rotating-frame overhauser spectroscopy (1)H NMR experiments for the selective identification of 1,2-glycosidic linkages in polysaccharides. Analytical Biochemistry. 278: 52-8. PMID 10640353 DOI: 10.1006/abio.1999.4414  0.72
1997 Feher VA, Zapf JW, Hoch JA, Whiteley JM, McIntosh LP, Rance M, Skelton NJ, Dahlquist FW, Cavanagh J. High-resolution NMR structure and backbone dynamics of the Bacillus subtilis response regulator, Spo0F: implications for phosphorylation and molecular recognition. Biochemistry. 36: 10015-25. PMID 9254596 DOI: 10.1021/bi970816l  0.72
1994 Liao X, Clemens K, Cavanagh J, Tennant L, Wright PE. 1H, 15N and 13C resonance assignments for the first three zinc fingers of transcription factor IIIA. Journal of Biomolecular Nmr. 4: 433-54. PMID 8019145  0.6
1994 Falzone CJ, Cavanagh J, Cowart M, Palmer AG, Matthews CR, Benkovic SJ, Wright PE. 1H, 15N and 13C resonance assignments, secondary structure, and the conformation of substrate in the binary folate complex of Escherichia coli dihydrofolate reductase. Journal of Biomolecular Nmr. 4: 349-66. PMID 8019142 DOI: 10.1007/BF00179346  0.72
1992 Palmer AG, Fairbrother WJ, Cavanagh J, Wright PE, Rance M. Improved resolution in three-dimensional constant-time triple resonance NMR spectroscopy of proteins. Journal of Biomolecular Nmr. 2: 103-8. PMID 1422144 DOI: 10.1007/BF02192804  0.72
1991 Fairbrother WJ, Cavanagh J, Dyson HJ, Palmer AG, Sutrina SL, Reizer J, Saier MH, Wright PE. Polypeptide backbone resonance assignments and secondary structure of Bacillus subtilis enzyme IIIglc determined by two-dimensional and three-dimensional heteronuclear NMR spectroscopy. Biochemistry. 30: 6896-907. PMID 1906345  0.6
1989 Lee MS, Cavanagh J, Wright PE. Complete assignment of the 1H NMR spectrum of a synthetic zinc finger from Xfin. Sequential resonance assignments and secondary structure. Febs Letters. 254: 159-64. PMID 2506074 DOI: 10.1016/0014-5793(89)81030-0  0.72
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