| Year |
Citation |
Score |
| 2023 |
Basagni F, Ortega JA, Bertozzi SM, Armirotti A, Summa M, Bertorelli R, Bartolini M, Mellor IR, Bedeschi M, Bottegoni G, Lembo V, Minarini A, Cavalli A, Rosini M. Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties. European Journal of Medicinal Chemistry. 261: 115803. PMID 37734258 DOI: 10.1016/j.ejmech.2023.115803 |
0.407 |
|
| 2023 |
Uliassi E, Bergamini C, Rizzardi N, Naldi M, Cores Á, Bartolini M, Carlos Menéndez J, Bolognesi ML. Quinolinetrione-tacrine hybrids as multi-target-directed ligands against Alzheimer's disease. Bioorganic & Medicinal Chemistry. 91: 117419. PMID 37487339 DOI: 10.1016/j.bmc.2023.117419 |
0.399 |
|
| 2022 |
Gandini A, Gonçalves AE, Strocchi S, Albertini C, Janočková J, Tramarin A, Grifoni D, Poeta E, Soukup O, Muñoz-Torrero D, Monti B, Sabaté R, Bartolini M, Legname G, Bolognesi ML. Discovery of Dual Aβ/Tau Inhibitors and Evaluation of Their Therapeutic Effect on a Model of Alzheimer's Disease. Acs Chemical Neuroscience. 13: 3314-3329. PMID 36445009 DOI: 10.1021/acschemneuro.2c00357 |
0.394 |
|
| 2022 |
Basagni F, Naldi M, Ginex T, Luque FJ, Fagiani F, Lanni C, Iurlo M, Marcaccio M, Minarini A, Bartolini M, Rosini M. Inhibition of β-Amyloid Aggregation in Alzheimer's Disease: The Key Role of (Pro)electrophilic Warheads. Acs Medicinal Chemistry Letters. 13: 1812-1818. PMID 36385935 DOI: 10.1021/acsmedchemlett.2c00410 |
0.353 |
|
| 2022 |
Bisi A, Feoli A, Trezza A, Viejo L, Formaggio F, Bartolini M, Belluti F, Gobbi S, Spiga O, Caprini M, de Los Rios C, Castellano S, Rampa A. Targeting neuronal calcium channels and GSK3β for Alzheimer's disease with naturally-inspired Diels-Alder adducts. Bioorganic Chemistry. 129: 106152. PMID 36155094 DOI: 10.1016/j.bioorg.2022.106152 |
0.358 |
|
| 2022 |
Codony S, Pont C, Griñán-Ferré C, Di Pede-Mattatelli A, Calvó-Tusell C, Feixas F, Osuna S, Jarné-Ferrer J, Naldi M, Bartolini M, Loza MI, Brea J, Pérez B, Bartra C, Sanfeliu C, et al. Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease. Journal of Medicinal Chemistry. 65: 4909-4925. PMID 35271276 DOI: 10.1021/acs.jmedchem.1c02150 |
0.4 |
|
| 2021 |
Pont C, Ginex T, Griñán-Ferré C, Scheiner M, Mattellone A, Martínez N, Arce EM, Soriano-Fernández Y, Naldi M, De Simone A, Barenys M, Gómez-Catalán J, Pérez B, Sabate R, Andrisano V, ... ... Bartolini M, et al. From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects. European Journal of Medicinal Chemistry. 225: 113779. PMID 34418785 DOI: 10.1016/j.ejmech.2021.113779 |
0.39 |
|
| 2021 |
de Andrade Ramos G, Souza de Oliveira A, Bartolini M, Naldi M, Liparulo I, Bergamini C, Uliassi E, Wu L, Fraser PE, Abreu M, Kiametis AS, Gargano R, Silveira ER, Brand GD, Prchal L, et al. Discovery of sustainable drugs for Alzheimer's disease: cardanol-derived cholinesterase inhibitors with antioxidant and anti-amyloid properties. Rsc Medicinal Chemistry. 12: 1154-1163. PMID 34355181 DOI: 10.1039/d1md00046b |
0.454 |
|
| 2021 |
Montanari S, Allarà M, Scalvini L, Kostrzewa M, Belluti F, Gobbi S, Naldi M, Rivara S, Bartolini M, Ligresti A, Bisi A, Rampa A. New Coumarin Derivatives as Cholinergic and Cannabinoid System Modulators. Molecules (Basel, Switzerland). 26. PMID 34071439 DOI: 10.3390/molecules26113254 |
0.441 |
|
| 2021 |
Tedesco D, Maj M, Malarczyk P, Cingolani A, Zaffagnini M, Wnorowski A, Czapiński J, Benelli T, Mazzoni R, Bartolini M, Jóźwiak K. Application of the SMALP technology to the isolation of GPCRs from low-yielding cell lines. Biochimica Et Biophysica Acta. Biomembranes. 183641. PMID 33984320 DOI: 10.1016/j.bbamem.2021.183641 |
0.532 |
|
| 2021 |
Gorecki L, Uliassi E, Bartolini M, Janockova J, Hrabinova M, Hepnarova V, Prchal L, Muckova L, Pejchal J, Karasova JZ, Mezeiova E, Benkova M, Kobrlova T, Soukup O, Petralla S, et al. Phenothiazine-Tacrine Heterodimers: Pursuing Multitarget Directed Approach in Alzheimer's Disease. Acs Chemical Neuroscience. 12: 1698-1715. PMID 33852284 DOI: 10.1021/acschemneuro.1c00184 |
0.41 |
|
| 2021 |
Rossi M, Freschi M, de Camargo Nascente L, Salerno A, de Melo Viana Teixeira S, Nachon F, Chantegreil F, Soukup O, Prchal L, Malaguti M, Bergamini C, Bartolini M, Angeloni C, Hrelia S, Soares Romeiro LA, et al. Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease. Journal of Medicinal Chemistry. 64: 4972-4990. PMID 33829779 DOI: 10.1021/acs.jmedchem.1c00048 |
0.382 |
|
| 2021 |
Ismaili L, Monnin J, Etievant A, Arribas RL, Viejo L, Refouvelet B, Soukup O, Janockova J, Hepnarova V, Korabecny J, Kucera T, Jun D, Andrys R, Musilek K, Baguet A, ... ... Bartolini M, et al. (±)-: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease. Acs Chemical Neuroscience. PMID 33797877 DOI: 10.1021/acschemneuro.0c00803 |
0.363 |
|
| 2021 |
Albertini C, Naldi M, Petralla S, Strocchi S, Grifoni D, Monti B, Bartolini M, Bolognesi ML. From Combinations to Single-Molecule Polypharmacology-Cromolyn-Ibuprofen Conjugates for Alzheimer's Disease. Molecules (Basel, Switzerland). 26. PMID 33669839 DOI: 10.3390/molecules26041112 |
0.391 |
|
| 2021 |
Perone R, Albertini C, Uliassi E, Di Pietri F, de Sena Murteira Pinheiro P, Petralla S, Rizzardi N, Fato R, Pulkrabkova L, Soukup O, Tramarin A, Bartolini M, Bolognesi ML. Turning Donepezil into a Multi-Target-Directed Ligand through a Merging Strategy. Chemmedchem. 16: 187-198. PMID 32716144 DOI: 10.1002/Cmdc.202000484 |
0.475 |
|
| 2020 |
Viayna E, Coquelle N, Cieslikiewicz-Bouet M, Cisternas P, Oliva CA, Sánchez-López E, Ettcheto M, Bartolini M, De Simone A, Ricchini M, Rendina M, Pons M, Firuzi O, Pérez B, Saso L, et al. Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice. Journal of Medicinal Chemistry. PMID 33356266 DOI: 10.1021/acs.jmedchem.0c01775 |
0.348 |
|
| 2020 |
Pérez-Areales FJ, Garrido M, Aso E, Bartolini M, De Simone A, Espargaro A, Ginex T, Sabaté R, Pérez B, Andrisano V, Puigoriol-Illamola D, Pallàs M, Luque FJ, Loza MI, Brea JM, et al. Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6. Journal of Medicinal Chemistry. PMID 32706255 DOI: 10.1021/Acs.Jmedchem.0C00528 |
0.479 |
|
| 2020 |
Cieslikiewicz-Bouet M, Naldi M, Bartolini M, Pérez B, Servent D, Jean L, Aráoz R, Renard PY. Functional characterization of multifunctional ligands targeting acetylcholinesterase and alpha 7 nicotinic acetylcholine receptor. Biochemical Pharmacology. 114010. PMID 32360492 DOI: 10.1016/J.Bcp.2020.114010 |
0.379 |
|
| 2020 |
Marques CS, López Ó, Bagetta D, Carreiro EP, Petralla S, Bartolini M, Hoffmann M, Alcaro S, Monti B, Bolognesi ML, Decker M, Fernández-Bolaños JG, Burke AJ. N-1,2,3-triazole-isatin derivatives for cholinesterase and β-amyloid aggregation inhibition: A comprehensive bioassay study. Bioorganic Chemistry. 98: 103753. PMID 32200328 DOI: 10.1016/J.Bioorg.2020.103753 |
0.505 |
|
| 2019 |
Scheiner M, Dolles D, Gunesch S, Hoffmann M, Nabissi M, Marinelli O, Naldi M, Bartolini M, Petralla S, Poeta E, Monti B, Falkeis C, Vieth M, Hübner H, Gmeiner P, et al. Dual-Acting Cholinesterase-Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo. Journal of Medicinal Chemistry. PMID 31609608 DOI: 10.1021/Acs.Jmedchem.9B00623 |
0.476 |
|
| 2019 |
De Simone A, Naldi M, Tedesco D, Bartolini M, Davani L, Andrisano V. Advanced analytical methodologies in Alzheimer's disease drug discovery. Journal of Pharmaceutical and Biomedical Analysis. 178: 112899. PMID 31606562 DOI: 10.1016/J.Jpba.2019.112899 |
0.458 |
|
| 2019 |
De Simone A, Naldi M, Tedesco D, Milelli A, Bartolini M, Davani L, Widera D, Dallas ML, Andrisano V. Investigating in Vitro Amyloid Peptide 1-42 Aggregation: Impact of Higher Molecular Weight Stable Adducts. Acs Omega. 4: 12308-12318. PMID 31460348 DOI: 10.1021/acsomega.9b01531 |
0.304 |
|
| 2019 |
Fabini E, Talibov VO, Mihalic F, Naldi M, Bartolini M, Bertucci C, Del Rio A, Danielson UH. Unveiling the biochemistry of the epigenetic regulator SMYD3. Biochemistry. PMID 31389685 DOI: 10.1021/Acs.Biochem.9B00420 |
0.347 |
|
| 2019 |
Roldán-Peña JM, Romero-Real V, Hicke J, Maya I, Franconetti A, Lagunes I, Padrón JM, Petralla S, Poeta E, Naldi M, Bartolini M, Monti B, Bolognesi ML, López Ó, Fernández-Bolaños JG. Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors. European Journal of Medicinal Chemistry. 181: 111550. PMID 31376562 DOI: 10.1016/J.Ejmech.2019.07.053 |
0.533 |
|
| 2019 |
Pérez-Areales FJ, Turcu AL, Barniol-Xicota M, Pont C, Pivetta D, Espargaró A, Bartolini M, De Simone A, Andrisano V, Pérez B, Sabate R, Sureda FX, Vázquez S, Muñoz-Torrero D. A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors. European Journal of Medicinal Chemistry. 180: 613-626. PMID 31351393 DOI: 10.1016/J.Ejmech.2019.07.051 |
0.453 |
|
| 2019 |
Montanari S, Mahmoud AM, Pruccoli L, Rabbito A, Naldi M, Petralla S, Moraleda I, Bartolini M, Monti B, Iriepa I, Belluti F, Gobbi S, Di Marzo V, Bisi A, Tarozzi A, et al. Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment. European Journal of Medicinal Chemistry. 178: 243-258. PMID 31185414 DOI: 10.1016/J.Ejmech.2019.05.080 |
0.523 |
|
| 2019 |
Ramos E, Palomino-Antolín A, Bartolini M, Iriepa I, Moraleda I, Diez-Iriepa D, Samadi A, Cortina CV, Chioua M, Egea J, Romero A, Marco-Contelles J. QuinoxalineTacrine QT78, a Cholinesterase Inhibitor as a Potential Ligand for Alzheimer's Disease Therapy. Molecules (Basel, Switzerland). 24. PMID 30999586 DOI: 10.3390/Molecules24081503 |
0.462 |
|
| 2019 |
Fabini E, Manoni E, Ferroni C, Rio AD, Bartolini M. Small-molecule inhibitors of lysine methyltransferases SMYD2 and SMYD3: current trends. Future Medicinal Chemistry. 11: 901-921. PMID 30998113 DOI: 10.4155/Fmc-2018-0380 |
0.366 |
|
| 2019 |
Chalupova K, Korabecny J, Bartolini M, Monti B, Lamba D, Caliandro R, Pesaresi A, Brazzolotto X, Gastellier AJ, Nachon F, Pejchal J, Jarosova M, Hepnarova V, Jun D, Hrabinova M, et al. Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease. European Journal of Medicinal Chemistry. 168: 491-514. PMID 30851693 DOI: 10.1016/J.Ejmech.2019.02.021 |
0.432 |
|
| 2019 |
Oukoloff K, Coquelle N, Bartolini M, Naldi M, Le Guevel R, Bach S, Josselin B, Ruchaud S, Catto M, Pisani L, Denora N, Iacobazzi RM, Silman I, Sussman JL, Buron F, et al. Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3. European Journal of Medicinal Chemistry. 168: 58-77. PMID 30798053 DOI: 10.1016/J.Ejmech.2018.12.063 |
0.447 |
|
| 2019 |
AlFadly ED, Elzahhar PA, Tramarin A, Elkazaz S, Shaltout H, Abu-Serie MM, Janockova J, Soukup O, Ghareeb DA, El-Yazbi AF, Rafeh RW, Bakkar NZ, Kobeissy F, Iriepa I, Moraleda I, ... ... Bartolini M, et al. Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase. European Journal of Medicinal Chemistry. 167: 161-186. PMID 30771604 DOI: 10.1016/J.Ejmech.2019.02.012 |
0.521 |
|
| 2019 |
Bartolini M, Marco-Contelles J. Tacrines as Therapeutic Agents for Alzheimer's Disease. IV. The Tacripyrines and Related Annulated Tacrines. Chemical Record (New York, N.Y.). 19: 927-937. PMID 30489012 DOI: 10.1002/Tcr.201800155 |
0.464 |
|
| 2019 |
Simone AD, Naldi M, Bartolini M, Davani L, Andrisano V. Immobilized Enzyme Reactors: an Overview of Applications in Drug Discovery from 2008 to 2018 Chromatographia. 82: 425-441. DOI: 10.1007/S10337-018-3663-5 |
0.382 |
|
| 2018 |
Gandini A, Bartolini M, Tedesco D, Martínez-González L, Roca C, Campillo NE, Zaldivar-Diez J, Perez C, Zuccheri G, Miti A, Feoli A, Castellano S, Petralla S, Monti B, Rossi M, et al. Tau-centric multi-target approach for Alzheimer's disease: development of first-in-class dual glycogen synthase kinase 3β and tau-aggregation inhibitors. Journal of Medicinal Chemistry. PMID 30078314 DOI: 10.1021/Acs.Jmedchem.8B00610 |
0.479 |
|
| 2018 |
Rampa A, Bartolini M, Pruccoli L, Naldi M, Iriepa I, Moraleda I, Belluti F, Gobbi S, Tarozzi A, Bisi A. Exploiting the Chalcone Scaffold to Develop Multifunctional Agents for Alzheimer's Disease. Molecules (Basel, Switzerland). 23. PMID 30061534 DOI: 10.3390/Molecules23081902 |
0.562 |
|
| 2018 |
Chioua M, Buzzi E, Moraleda I, Iriepa I, Maj M, Wnorowski A, Giovannini C, Tramarin A, Portali F, Ismaili L, López-Alvarado P, Bolognesi ML, Jóźwiak K, Menéndez JC, Marco-Contelles J, ... Bartolini M, et al. Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease. European Journal of Medicinal Chemistry. 155: 839-846. PMID 29958119 DOI: 10.1016/J.Ejmech.2018.06.044 |
0.671 |
|
| 2018 |
Andrisano V, Naldi M, De Simone A, Bartolini M. A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017. Expert Opinion On Therapeutic Patents. PMID 29757691 DOI: 10.1080/13543776.2018.1476494 |
0.511 |
|
| 2018 |
Fabini E, Tramarin A, Bartolini M. Combination of human acetylcholinesterase and serum albumin sensing surfaces as highly informative analytical tool for inhibitor screening. Journal of Pharmaceutical and Biomedical Analysis. 155: 177-184. PMID 29635172 DOI: 10.1016/J.Jpba.2018.03.060 |
0.397 |
|
| 2018 |
Galdeano C, Coquelle N, Cieslikiewicz-Bouet M, Bartolini M, Pérez B, Clos MV, Silman I, Jean L, Colletier JP, Renard PY, Muñoz-Torrero D. Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis. Molecules (Basel, Switzerland). 23. PMID 29534488 DOI: 10.3390/Molecules23030634 |
0.466 |
|
| 2017 |
Wang L, Moraleda I, Iriepa I, Romero A, López-Muñoz F, Chioua M, Inokuchi T, Bartolini M, Marco-Contelles J. 5-Methyl--(8-(5,6,7,8-tetrahydroacridin-9-ylamino)octyl)-5-indolo[2,3-]quinolin-11-amine: a highly potent human cholinesterase inhibitor. Medchemcomm. 8: 1307-1317. PMID 30108842 DOI: 10.1039/C7Md00143F |
0.467 |
|
| 2017 |
Pandolfi F, De Vita D, Bortolami M, Coluccia A, Di Santo R, Costi R, Andrisano V, Alabiso F, Bergamini C, Fato R, Bartolini M, Scipione L. New pyridine derivatives as inhibitors of acetylcholinesterase and amyloid aggregation. European Journal of Medicinal Chemistry. 141: 197-210. PMID 29031067 DOI: 10.1016/J.Ejmech.2017.09.022 |
0.479 |
|
| 2017 |
De Simone A, Bartolini M, Baschieri A, Apperley KYP, Chen HH, Guardigni M, Montanari S, Kobrlova T, Soukup O, Valgimigli L, Andrisano V, Keillor JW, Basso M, Milelli A. Hydroxy-substituted trans-cinnamoyl derivatives as multifunctional tools in the context of Alzheimer's disease. European Journal of Medicinal Chemistry. 139: 378-389. PMID 28810189 DOI: 10.1016/J.Ejmech.2017.07.058 |
0.47 |
|
| 2017 |
Roldán-Peña JM, Alejandre-Ramos D, López Ó, Maya I, Lagunes I, Padrón JM, Peña-Altamira LE, Bartolini M, Monti B, Bolognesi ML, Fernández-Bolaños JG. New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents. European Journal of Medicinal Chemistry. 138: 761-773. PMID 28728108 DOI: 10.1016/J.Ejmech.2017.06.048 |
0.523 |
|
| 2017 |
Simoni E, Bartolini M, Abu IF, Blockley A, Gotti C, Bottegoni G, Caporaso R, Bergamini C, Andrisano V, Cavalli A, Mellor IR, Minarini A, Rosini M. Multitarget drug design strategy in Alzheimer's disease: focus on cholinergic transmission and amyloid-β aggregation. Future Medicinal Chemistry. 9: 953-963. PMID 28632446 DOI: 10.4155/Fmc-2017-0039 |
0.41 |
|
| 2017 |
Pérez-Areales FJ, Betari N, Viayna A, Pont C, Espargaró A, Bartolini M, De Simone A, Rinaldi Alvarenga JF, Pérez B, Sabate R, Lamuela-Raventós RM, Andrisano V, Luque FJ, Muñoz-Torrero D. Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein-huprine hybrids. Future Medicinal Chemistry. 9: 965-981. PMID 28632395 DOI: 10.4155/Fmc-2017-0049 |
0.434 |
|
| 2017 |
Rampa A, Montanari S, Pruccoli L, Bartolini M, Falchi F, Feoli A, Cavalli A, Belluti F, Gobbi S, Tarozzi A, Bisi A. Chalcone-based carbamates for Alzheimer's disease treatment. Future Medicinal Chemistry. 9: 749-764. PMID 28498775 DOI: 10.4155/Fmc-2017-0029 |
0.53 |
|
| 2017 |
Naldi M, Baldassarre M, Domenicali M, Bartolini M, Caraceni P. Structural and functional integrity of human serum albumin: Analytical approaches and clinical relevance in patients with liver cirrhosis. Journal of Pharmaceutical and Biomedical Analysis. 144: 138-153. PMID 28465079 DOI: 10.1016/J.Jpba.2017.04.023 |
0.312 |
|
| 2017 |
Simoni E, Serafini MM, Caporaso R, Marchetti C, Racchi M, Minarini A, Bartolini M, Lanni C, Rosini M. Targeting the Nrf2/Amyloid-Beta Liaison in Alzheimer's Disease: A Rational Approach. Acs Chemical Neuroscience. 8: 1618-1627. PMID 28421738 DOI: 10.1021/Acschemneuro.7B00100 |
0.49 |
|
| 2017 |
Terra BS, Silva PHCd, Tramarin A, Franco LL, Cunha EFFd, Junior FM, Ramalho TC, Bartolini M, Bolognesi ML, Fátima Âd. Two Novel Donepezil-Lipoic Acid Hybrids: Synthesis, Anticholinesterase and Antioxidant Activities and Theoretical Studies Journal of the Brazilian Chemical Society. 29: 738-747. DOI: 10.21577/0103-5053.20170196 |
0.303 |
|
| 2016 |
Jeřábek J, Uliassi E, Guidotti L, Korábečný J, Soukup O, Sepsova V, Hrabinova M, Kuča K, Bartolini M, Peña-Altamira LE, Petralla S, Monti B, Roberti M, Bolognesi ML. Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease. European Journal of Medicinal Chemistry. 127: 250-262. PMID 28064079 DOI: 10.1016/J.Ejmech.2016.12.048 |
0.501 |
|
| 2016 |
Simoni E, Caporaso R, Bergamini C, Fiori J, Fato R, Miszta P, Filipek S, Caraci F, Giuffrida ML, Andrisano V, Minarini A, Bartolini M, Rosini M. Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer's Disease. Acs Medicinal Chemistry Letters. 7: 1145-1150. PMID 27994754 DOI: 10.1021/Acsmedchemlett.6B00339 |
0.472 |
|
| 2016 |
Seidl C, de Moraes Santos CA, De Simone A, Bartolini M, Weffort-Santos AM, Andrisano V. Uleine disrupts key enzymatic and non-enzymatic biomarkers that leads to Alzheimer's disease. Current Alzheimer Research. PMID 27784218 DOI: 10.2174/1567205013666161026150455 |
0.471 |
|
| 2016 |
Montanari S, Scalvini L, Bartolini M, Belluti F, Gobbi S, Andrisano V, Ligresti A, Di Marzo V, Rivara S, Mor M, Bisi A, Rampa A. Fatty acid amide hydrolase (FAAH), acethylcholinesterase (AChE) and butyrylcholinesterase (BuChE): networked targets for the development of carbamates as potential anti Alzheimer's Disease agents. Journal of Medicinal Chemistry. PMID 27309570 DOI: 10.1021/Acs.Jmedchem.6B00609 |
0.503 |
|
| 2016 |
Boulebd H, Ismaili L, Bartolini M, Bouraiou A, Andrisano V, Martin H, Bonet A, Moraleda I, Iriepa I, Chioua M, Belfaitah A, Marco-Contelles J. Imidazopyranotacrines as Non-Hepatotoxic, Selective Acetylcholinesterase Inhibitors, and Antioxidant Agents for Alzheimer's Disease Therapy. Molecules (Basel, Switzerland). 21. PMID 27023499 DOI: 10.3390/Molecules21040400 |
0.438 |
|
| 2016 |
Prati F, Bergamini C, Fato R, Soukup O, Korabecny J, Andrisano V, Bartolini M, Bolognesi ML. Novel 8-Hydroxyquinoline Derivatives as Multitarget Compounds for the Treatment of Alzheimer's Disease. Chemmedchem. 11: 1284-95. PMID 26880501 DOI: 10.1002/Cmdc.201600014 |
0.52 |
|
| 2016 |
Lemes LF, de Andrade Ramos G, de Oliveira AS, da Silva FM, de Castro Couto G, da Silva Boni M, Guimarães MJ, Souza IN, Bartolini M, Andrisano V, do Nascimento Nogueira PC, Silveira ER, Brand GD, Soukup O, Korábečný J, et al. Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease. European Journal of Medicinal Chemistry. 108: 687-700. PMID 26735910 DOI: 10.1016/J.Ejmech.2015.12.024 |
0.507 |
|
| 2016 |
Wang CH, Alluri S, Nikogosyan G, Decarlo C, Monteiro C, Mabagos G, Feng HH, White AR, Bartolini M, Andrisano V, Zhang LK, Ganguly AK. Novel synthesis of physovenine and physostigmine analogs Tetrahedron Letters. 57: 3046-3049. DOI: 10.1016/J.Tetlet.2016.06.005 |
0.371 |
|
| 2015 |
Zha X, Lamba D, Zhang L, Lou Y, Xu C, Kang D, Chen L, Xu Y, Zhang L, De Simone A, Samez S, Pesaresi A, Stojan J, López MG, Egea J, ... ... Bartolini M, et al. Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation and X-ray Crystallography. Journal of Medicinal Chemistry. PMID 26632651 DOI: 10.1021/Acs.Jmedchem.5B01119 |
0.495 |
|
| 2015 |
Montanari S, Bartolini M, Neviani P, Belluti F, Gobbi S, Pruccoli L, Tarozzi A, Falchi F, Andrisano V, Miszta P, Cavalli A, Filipek S, Bisi A, Rampa A. Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives. Chemmedchem. PMID 26507467 DOI: 10.1002/Cmdc.201500392 |
0.463 |
|
| 2015 |
Simoni E, Serafini MM, Bartolini M, Caporaso R, Pinto A, Necchi D, Fiori J, Andrisano V, Minarini A, Lanni C, Rosini M. Nature-Inspired Multifunctional Ligands: Focusing on Amyloid-Based Molecular Mechanisms of Alzheimer's Disease. Chemmedchem. PMID 26497622 DOI: 10.1002/Cmdc.201500422 |
0.464 |
|
| 2015 |
Rampa A, Mancini F, De Simone A, Falchi F, Belluti F, Di Martino RM, Gobbi S, Andrisano V, Tarozzi A, Bartolini M, Cavalli A, Bisi A. From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold. Bioorganic & Medicinal Chemistry Letters. 25: 2804-8. PMID 26003339 DOI: 10.1016/J.Bmcl.2015.05.002 |
0.501 |
|
| 2015 |
Benchekroun M, Bartolini M, Egea J, Romero A, Soriano E, Pudlo M, Luzet V, Andrisano V, Jimeno ML, López MG, Wehle S, Gharbi T, Refouvelet B, de Andrés L, Herrera-Arozamena C, et al. Novel tacrine-grafted Ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic acid hybrids. Chemmedchem. 10: 523-39. PMID 25537267 DOI: 10.1002/Cmdc.201402409 |
0.489 |
|
| 2015 |
Aráoz R, Bouet M, Bartolini M, Coquelle N, Colletier J, Servent D, Molgo J, Jean L, Renard P. Multi-target directed ligands: Electrophysiological characterization of an anticholinesterase inhibitor coupled to an agonist of α7 nicotinic acetylcholine receptor Biochemical Pharmacology. 97: 621. DOI: 10.1016/J.Bcp.2015.08.006 |
0.307 |
|
| 2014 |
Tarozzi A, Bartolini M, Piazzi L, Valgimigli L, Amorati R, Bolondi C, Djemil A, Mancini F, Andrisano V, Rampa A. From the dual function lead AP2238 to AP2469, a multi-target-directed ligand for the treatment of Alzheimer's disease. Pharmacology Research & Perspectives. 2: e00023. PMID 25505579 DOI: 10.1002/Prp2.23 |
0.482 |
|
| 2014 |
Nepovimova E, Uliassi E, Korabecny J, Peña-Altamira LE, Samez S, Pesaresi A, Garcia GE, Bartolini M, Andrisano V, Bergamini C, Fato R, Lamba D, Roberti M, Kuca K, Monti B, et al. Multitarget drug design strategy: Quinone-tacrine hybrids designed to block amyloid-β aggregation and to exert anticholinesterase and antioxidant effects Journal of Medicinal Chemistry. 57: 8576-8589. PMID 25259726 DOI: 10.1021/Jm5010804 |
0.485 |
|
| 2014 |
Brogi S, Butini S, Maramai S, Colombo R, Verga L, Lanni C, De Lorenzi E, Lamponi S, Andreassi M, Bartolini M, Andrisano V, Novellino E, Campiani G, Brindisi M, Gemma S. Disease-modifying anti-Alzheimer's drugs: inhibitors of human cholinesterases interfering with β-amyloid aggregation. Cns Neuroscience & Therapeutics. 20: 624-32. PMID 24935788 DOI: 10.1111/Cns.12290 |
0.455 |
|
| 2014 |
Belluti F, De Simone A, Tarozzi A, Bartolini M, Djemil A, Bisi A, Gobbi S, Montanari S, Cavalli A, Andrisano V, Bottegoni G, Rampa A. Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease. European Journal of Medicinal Chemistry. 78: 157-66. PMID 24681980 DOI: 10.1016/J.Ejmech.2014.03.042 |
0.521 |
|
| 2014 |
Viayna E, Sola I, Bartolini M, De Simone A, Tapia-Rojas C, Serrano FG, Sabaté R, Juárez-Jiménez J, Pérez B, Luque FJ, Andrisano V, Clos MV, Inestrosa NC, Muñoz-Torrero D. Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents. Journal of Medicinal Chemistry. 57: 2549-67. PMID 24568372 DOI: 10.1021/Jm401824W |
0.455 |
|
| 2014 |
Di Pietro O, Viayna E, Vicente-García E, Bartolini M, Ramón R, Juárez-Jiménez J, Clos MV, Pérez B, Andrisano V, Luque FJ, Lavilla R, Muñoz-Torrero D. 1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: synthesis, pharmacological evaluation and mechanistic studies. European Journal of Medicinal Chemistry. 73: 141-52. PMID 24389509 DOI: 10.1016/J.Ejmech.2013.12.008 |
0.479 |
|
| 2013 |
Staderini M, Auli? S, Bartolini M, Tran HN, González-Ruiz V, Pérez DI, Cabezas N, Martínez A, Martín MA, Andrisano V, Legname G, Menéndez JC, Bolognesi ML. A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer's and Prion Diseases. Acs Medicinal Chemistry Letters. 4: 225-9. PMID 24900645 DOI: 10.1021/Ml3003605 |
0.434 |
|
| 2013 |
Butini S, Brindisi M, Brogi S, Maramai S, Guarino E, Panico A, Saxena A, Chauhan V, Colombo R, Verga L, De Lorenzi E, Bartolini M, Andrisano V, Novellino E, Campiani G, et al. Multifunctional cholinesterase and amyloid Beta fibrillization modulators. Synthesis and biological investigation. Acs Medicinal Chemistry Letters. 4: 1178-82. PMID 24900626 DOI: 10.1021/Ml4002908 |
0.453 |
|
| 2013 |
Prati F, Bartolini M, Simoni E, De Simone A, Pinto A, Andrisano V, Bolognesi ML. Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer's disease. Bioorganic & Medicinal Chemistry Letters. 23: 6254-8. PMID 24140444 DOI: 10.1016/J.Bmcl.2013.09.091 |
0.509 |
|
| 2013 |
Rosini M, Simoni E, Bartolini M, Soriano E, Marco-Contelles J, Andrisano V, Monti B, Windisch M, Hutter-Paier B, McClymont DW, Mellor IR, Bolognesi ML. The bivalent ligand approach as a tool for improving the in vitro anti-Alzheimer multitarget profile of dimebon. Chemmedchem. 8: 1276-81. PMID 23824986 DOI: 10.1002/Cmdc.201300263 |
0.345 |
|
| 2013 |
Bartolini M, Naldi M, Nicolau DV, van Delft FC, van Zijl J, Snijder J, van den Heuvel EF, Naburgh EP, Calonghi N, Andrisano V. Fluorescence biosensing micropatterned surfaces based on immobilized human acetylcholinesterase. Analytical and Bioanalytical Chemistry. 405: 795-804. PMID 22814970 DOI: 10.1007/S00216-012-6237-7 |
0.31 |
|
| 2012 |
Rampa A, Bartolini M, Bisi A, Belluti F, Gobbi S, Andrisano V, Ligresti A, Di Marzo V. The First Dual ChE/FAAH Inhibitors: New Perspectives for Alzheimer's Disease? Acs Medicinal Chemistry Letters. 3: 182-6. PMID 24900454 DOI: 10.1021/Ml200313P |
0.476 |
|
| 2012 |
Rizzo S, Tarozzi A, Bartolini M, Da Costa G, Bisi A, Gobbi S, Belluti F, Ligresti A, Allarà M, Monti JP, Andrisano V, Di Marzo V, Hrelia P, Rampa A. 2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents European Journal of Medicinal Chemistry. 58: 519-532. PMID 23164658 DOI: 10.1016/J.Ejmech.2012.10.045 |
0.544 |
|
| 2012 |
Fiori J, Naldi M, Bartolini M, Andrisano V. Disclosure of a fundamental clue for the elucidation of the myricetin mechanism of action as amyloid aggregation inhibitor by mass spectrometry. Electrophoresis. 33: 3380-6. PMID 22961751 DOI: 10.1002/Elps.201200186 |
0.416 |
|
| 2012 |
Samadi A, de los Ríos C, Bolea I, Chioua M, Iriepa I, Moraleda I, Bartolini M, Andrisano V, Gálvez E, Valderas C, Unzeta M, Marco-Contelles J. Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine. European Journal of Medicinal Chemistry. 52: 251-62. PMID 22503231 DOI: 10.1016/J.Ejmech.2012.03.022 |
0.494 |
|
| 2012 |
Galdeano C, Viayna E, Sola I, Formosa X, Camps P, Badia A, Clos MV, Relat J, Ratia M, Bartolini M, Mancini F, Andrisano V, Salmona M, Minguillón C, González-Muñoz GC, et al. Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases. Journal of Medicinal Chemistry. 55: 661-9. PMID 22185619 DOI: 10.1021/Jm200840C |
0.532 |
|
| 2012 |
Minarini A, Milelli A, Tumiatti V, Rosini M, Simoni E, Bolognesi ML, Andrisano V, Bartolini M, Motori E, Angeloni C, Hrelia S. Cystamine-tacrine dimer: a new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment. Neuropharmacology. 62: 997-1003. PMID 22032870 DOI: 10.1016/J.Neuropharm.2011.10.007 |
0.525 |
|
| 2011 |
Bolognesi ML, Chiriano G, Bartolini M, Mancini F, Bottegoni G, Maestri V, Czvitkovich S, Windisch M, Cavalli A, Minarini A, Rosini M, Tumiatti V, Andrisano V, Melchiorre C. Synthesis of monomeric derivatives to probe memoquin's bivalent interactions. Journal of Medicinal Chemistry. 54: 8299-304. PMID 22054058 DOI: 10.1021/Jm200691D |
0.488 |
|
| 2011 |
Martins C, Carreiras MC, León R, de los RÃos C, Bartolini M, Andrisano V, Iriepa I, Moraleda I, Gálvez E, GarcÃa M, Egea J, Samadi A, Chioua M, Marco-Contelles J. Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues. European Journal of Medicinal Chemistry. 46: 6119-30. PMID 22000936 DOI: 10.1016/J.Ejmech.2011.09.038 |
0.409 |
|
| 2011 |
Bartolini M, Pistolozzi M, Andrisano V, Egea J, López MG, Iriepa I, Moraleda I, Gálvez E, Marco-Contelles J, Samadi A. Chemical and pharmacological studies on enantiomerically pure p-methoxytacripyrines, promising multi-target-directed ligands for the treatment of Alzheimer's disease. Chemmedchem. 6: 1990-7. PMID 21990269 DOI: 10.1002/Cmdc.201100239 |
0.388 |
|
| 2011 |
Rosini M, Simoni E, Bartolini M, Tarozzi A, Matera R, Milelli A, Hrelia P, Andrisano V, Bolognesi ML, Melchiorre C. Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease European Journal of Medicinal Chemistry. 46: 5435-5442. PMID 21924801 DOI: 10.1016/J.Ejmech.2011.09.001 |
0.473 |
|
| 2011 |
Rizzo S, Bisi A, Bartolini M, Mancini F, Belluti F, Gobbi S, Andrisano V, Rampa A. Multi-target strategy to address Alzheimer's disease: design, synthesis and biological evaluation of new tacrine-based dimers. European Journal of Medicinal Chemistry. 46: 4336-43. PMID 21798635 DOI: 10.1016/J.Ejmech.2011.07.004 |
0.511 |
|
| 2011 |
Bartolini M, Naldi M, Fiori J, Valle F, Biscarini F, Nicolau DV, Andrisano V. Kinetic characterization of amyloid-beta 1-42 aggregation with a multimethodological approach. Analytical Biochemistry. 414: 215-25. PMID 21435333 DOI: 10.1016/J.Ab.2011.03.020 |
0.358 |
|
| 2011 |
Belluti F, Bartolini M, Bottegoni G, Bisi A, Cavalli A, Andrisano V, Rampa A. Benzophenone-based derivatives: a novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation. European Journal of Medicinal Chemistry. 46: 1682-93. PMID 21397996 DOI: 10.1016/J.Ejmech.2011.02.019 |
0.54 |
|
| 2011 |
Bolognesi ML, Bartolini M, Tarozzi A, Morroni F, Lizzi F, Milelli A, Minarini A, Rosini M, Hrelia P, Andrisano V, Melchiorre C. Multitargeted drugs discovery: Balancing anti-amyloid and anticholinesterase capacity in a single chemical entity Bioorganic and Medicinal Chemistry Letters. 21: 2655-2658. PMID 21236667 DOI: 10.1016/J.Bmcl.2010.12.093 |
0.564 |
|
| 2010 |
Viayna E, Gómez T, Galdeano C, RamÃrez L, Ratia M, Badia A, Clos MV, Verdaguer E, Junyent F, Camins A, Pallà s M, Bartolini M, Mancini F, Andrisano V, Arce MP, et al. Novel huprine derivatives with inhibitory activity toward β-amyloid aggregation and formation as disease-modifying anti-Alzheimer drug candidates. Chemmedchem. 5: 1855-70. PMID 20859987 DOI: 10.1002/Cmdc.201000322 |
0.513 |
|
| 2010 |
Bolognesi ML, Bartolini M, Mancini F, Chiriano G, Ceccarini L, Rosini M, Milelli A, Tumiatti V, Andrisano V, Melchiorre C. Bis(7)-tacrine derivatives as multitarget-directed ligands: Focus on anticholinesterase and antiamyloid activities. Chemmedchem. 5: 1215-20. PMID 20486153 DOI: 10.1002/Cmdc.201000086 |
0.368 |
|
| 2010 |
Bartolini M, Andrisano V. Strategies for the inhibition of protein aggregation in human diseases. Chembiochem : a European Journal of Chemical Biology. 11: 1018-35. PMID 20401887 DOI: 10.1002/Cbic.200900666 |
0.383 |
|
| 2010 |
Rizzo S, Bartolini M, Ceccarini L, Piazzi L, Gobbi S, Cavalli A, Recanatini M, Andrisano V, Rampa A. Targeting Alzheimer's disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238. Bioorganic & Medicinal Chemistry. 18: 1749-60. PMID 20171894 DOI: 10.1016/J.Bmc.2010.01.071 |
0.507 |
|
| 2010 |
Camps P, Formosa X, Galdeano C, Gómez T, Muñoz-Torrero D, RamÃrez L, Viayna E, Gómez E, Isambert N, Lavilla R, Badia A, Clos MV, Bartolini M, Mancini F, Andrisano V, et al. Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates. Chemico-Biological Interactions. 187: 411-5. PMID 20167211 DOI: 10.1016/J.Cbi.2010.02.013 |
0.496 |
|
| 2009 |
Bolognesi ML, Cavalli A, Bergamini C, Fato R, Lenaz G, Rosini M, Bartolini M, Andrisano V, Melchiorre C. Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks. Journal of Medicinal Chemistry. 52: 7883-6. PMID 19813747 DOI: 10.1021/Jm901123N |
0.435 |
|
| 2009 |
Camps P, Formosa X, Galdeano C, Muñoz-Torrero D, RamÃrez L, Gómez E, Isambert N, Lavilla R, Badia A, Clos MV, Bartolini M, Mancini F, Andrisano V, Arce MP, RodrÃguez-Franco MI, et al. Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds. Journal of Medicinal Chemistry. 52: 5365-79. PMID 19663388 DOI: 10.1021/Jm900859Q |
0.497 |
|
| 2009 |
Bolognesi ML, Bartolini M, Rosini M, Andrisano V, Melchiorre C. Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action. Bioorganic & Medicinal Chemistry Letters. 19: 4312-5. PMID 19505825 DOI: 10.1016/J.Bmcl.2009.05.087 |
0.433 |
|
| 2009 |
Marco-Contelles J, León R, de los RÃos C, Samadi A, Bartolini M, Andrisano V, Huertas O, Barril X, Luque FJ, RodrÃguez-Franco MI, López B, López MG, GarcÃa AG, Carreiras Mdo C, Villarroya M. Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease. Journal of Medicinal Chemistry. 52: 2724-32. PMID 19374444 DOI: 10.1021/Jm801292B |
0.525 |
|
| 2009 |
Rizzo S, Cavalli A, Ceccarini L, Bartolini M, Belluti F, Bisi A, Andrisano V, Recanatini M, Rampa A. Structure-activity relationships and binding mode in the human acetylcholinesterase active site of pseudo-irreversible inhibitors related to xanthostigmine. Chemmedchem. 4: 670-9. PMID 19222043 DOI: 10.1002/Cmdc.200800396 |
0.467 |
|
| 2009 |
Bolognesi ML, Rosini M, Andrisano V, Bartolini M, Minarini A, Tumiatti V, Melchiorre C. MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond. Current Pharmaceutical Design. 15: 601-13. PMID 19199985 DOI: 10.2174/138161209787315585 |
0.387 |
|
| 2009 |
Bartolini M, Greig NH, Yu QS, Andrisano V. Immobilized butyrylcholinesterase in the characterization of new inhibitors that could ease Alzheimer's disease. Journal of Chromatography. A. 1216: 2730-8. PMID 18950780 DOI: 10.1016/J.Chroma.2008.09.100 |
0.505 |
|
| 2009 |
Belluti F, Piazzi L, Bisi A, Gobbi S, Bartolini M, Cavalli A, Valenti P, Rampa A. Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors. European Journal of Medicinal Chemistry. 44: 1341-8. PMID 18396354 DOI: 10.1016/J.Ejmech.2008.02.035 |
0.448 |
|
| 2008 |
Tumiatti V, Milelli A, Minarini A, Rosini M, Bolognesi ML, Micco M, Andrisano V, Bartolini M, Mancini F, Recanatini M, Cavalli A, Melchiorre C. Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inner spacer. Journal of Medicinal Chemistry. 51: 7308-12. PMID 18954037 DOI: 10.1021/Jm8009684 |
0.524 |
|
| 2008 |
Rosini M, Simoni E, Bartolini M, Cavalli A, Ceccarini L, Pascu N, McClymont DW, Tarozzi A, Bolognesi ML, Minarini A, Tumiatti V, Andrisano V, Mellor IR, Melchiorre C. Inhibition of acetylcholinesterase, β-amyloid aggregation, and NMDA receptors in Alzheimer's disease: A promising direction for the multi-target-directed ligands gold rush Journal of Medicinal Chemistry. 51: 4381-4384. PMID 18605718 DOI: 10.1021/Jm800577J |
0.506 |
|
| 2008 |
Nicoli R, Bartolini M, Rudaz S, Andrisano V, Veuthey J. Development of immobilized enzyme reactors based on human recombinant cytochrome P450 enzymes for phase I drug metabolism studies. Journal of Chromatography A. 1206: 2-10. PMID 18556005 DOI: 10.1016/J.Chroma.2008.05.080 |
0.3 |
|
| 2008 |
Camps P, Formosa X, Galdeano C, Gómez T, Muñoz-Torrero D, Scarpellini M, Viayna E, Badia A, Clos MV, Camins A, Pallàs M, Bartolini M, Mancini F, Andrisano V, Estelrich J, et al. Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation. Journal of Medicinal Chemistry. 51: 3588-98. PMID 18517184 DOI: 10.1021/Jm8001313 |
0.515 |
|
| 2008 |
Rizzo S, Rivière C, Piazzi L, Bisi A, Gobbi S, Bartolini M, Andrisano V, Morroni F, Tarozzi A, Monti JP, Rampa A. Benzofuran-based hybrid compounds for the inhibition of cholinesterase activity, β amyloid aggregation, and Aβ neurotoxicity Journal of Medicinal Chemistry. 51: 2883-2886. PMID 18419109 DOI: 10.1021/Jm8002747 |
0.515 |
|
| 2008 |
Piazzi L, Cavalli A, Colizzi F, Belluti F, Bartolini M, Mancini F, Recanatini M, Andrisano V, Rampa A. Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds. Bioorganic & Medicinal Chemistry Letters. 18: 423-6. PMID 17998161 DOI: 10.1016/J.Bmcl.2007.09.100 |
0.532 |
|
| 2007 |
Bolognesi ML, Cavalli A, Valgimigli L, Bartolini M, Rosini M, Andrisano V, Recanatini M, Melchiorre C. Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease. Journal of Medicinal Chemistry. 50: 6446-9. PMID 18047264 DOI: 10.1021/Jm701225U |
0.524 |
|
| 2007 |
Bartolini M, Bertucci C, Bolognesi ML, Cavalli A, Melchiorre C, Andrisano V. Insight into the kinetic of amyloid beta (1-42) peptide self-aggregation: elucidation of inhibitors' mechanism of action. Chembiochem : a European Journal of Chemical Biology. 8: 2152-61. PMID 17939148 DOI: 10.1002/Cbic.200700427 |
0.404 |
|
| 2007 |
Bolognesi ML, Banzi R, Bartolini M, Cavalli A, Tarozzi A, Andrisano V, Minarini A, Rosini M, Tumiatti V, Bergamini C, Fato R, Lenaz G, Hrelia P, Cattaneo A, Recanatini M, et al. Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease. Journal of Medicinal Chemistry. 50: 4882-97. PMID 17850125 DOI: 10.1021/Jm070559A |
0.494 |
|
| 2007 |
Piazzi L, Cavalli A, Belluti F, Bisi A, Gobbi S, Rizzo S, Bartolini M, Andrisano V, Recanatini M, Rampa A. Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives. Journal of Medicinal Chemistry. 50: 4250-4254. PMID 17655212 DOI: 10.1021/Jm070100G |
0.483 |
|
| 2007 |
Cavalli A, Bolognesi ML, Capsoni S, Andrisano V, Bartolini M, Margotti E, Cattaneo A, Recanatini M, Melchiorre C. A small molecule targeting the multifactorial nature of Alzheimer's disease. Angewandte Chemie (International Ed. in English). 46: 3689-92. PMID 17397121 DOI: 10.1002/Anie.200700256 |
0.4 |
|
| 2007 |
Bartolini M, Cavrini V, Andrisano V. Characterization of reversible and pseudo-irreversible acetylcholinesterase inhibitors by means of an immobilized enzyme reactor Journal of Chromatography A. 1144: 102-110. PMID 17134713 DOI: 10.1016/J.Chroma.2006.11.029 |
0.436 |
|
| 2007 |
Piazzi L, Belluti F, Bisi A, Gobbi S, Rizzo S, Bartolini M, Andrisano V, Recanatini M, Rampa A. Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones. Bioorganic & Medicinal Chemistry. 15: 575-585. PMID 17008100 DOI: 10.1016/J.Bmc.2006.09.026 |
0.488 |
|
| 2006 |
Gotti R, Fiori J, Bartolini M, Cavrini V. Analysis of Amaryllidaceae alkaloids from Narcissus by GC-MS and capillary electrophoresis. Journal of Pharmaceutical and Biomedical Analysis. 42: 17-24. PMID 16460902 DOI: 10.1016/J.Jpba.2006.01.003 |
0.304 |
|
| 2006 |
Capsoni S, Andrisano V, Bartolini M, Bolognesi ML, Cavalli A, Margotti E, Melchiorre C, Recanatini M, Cattaneo A. S4-04-04: Memoquin, a novel multifunctional compound for Alzheimer's disease: An up-date on preclinical studies Alzheimer's & Dementia. 2: S73-S74. DOI: 10.1016/J.Jalz.2006.05.287 |
0.445 |
|
| 2005 |
Muñoz-Ruiz P, Rubio L, García-Palomero E, Dorronsoro I, del Monte-Millán M, Valenzuela R, Usán P, de Austria C, Bartolini M, Andrisano V, Bidon-Chanal A, Orozco M, Luque FJ, Medina M, Martínez A. Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease. Journal of Medicinal Chemistry. 48: 7223-33. PMID 16279781 DOI: 10.1021/Jm0503289 |
0.543 |
|
| 2005 |
Belluti F, Rampa A, Piazzi L, Bisi A, Gobbi S, Bartolini M, Andrisano V, Cavalli A, Recanatini M, Valenti P. Cholinesterase Inhibitors: Xanthostigmine Derivatives Blocking the Acetylcholinesterase-Induced β-Amyloid Aggregation Journal of Medicinal Chemistry. 48: 4444-4456. PMID 15974596 DOI: 10.1021/Jm049515H |
0.494 |
|
| 2005 |
Bartolini M, Cavrini V, Andrisano V. Batchwise covalent immobilization of human acetylcholinesterase: kinetic and inhibition spectrophotometric studies. Analytical Biochemistry. 342: 163-166. PMID 15958194 DOI: 10.1016/J.Ab.2005.03.028 |
0.333 |
|
| 2005 |
Bolognesi ML, Andrisano V, Bartolini M, Cavalli A, Minarini A, Recanatini M, Rosini M, Tumiatti V, Melchiorre C. Heterocyclic inhibitors of AChE acylation and peripheral sites. Farmaco (Societa Chimica Italiana : 1989). 60: 465-73. PMID 15878569 DOI: 10.1016/J.Farmac.2005.03.010 |
0.436 |
|
| 2005 |
Bartolini M, Cavrini V, Andrisano V. Choosing the right chromatographic support in making a new acetylcholinesterase-micro-immobilised enzyme reactor for drug discovery. Journal of Chromatography A. 1065: 135-144. PMID 15782960 DOI: 10.1016/J.Chroma.2004.10.086 |
0.324 |
|
| 2005 |
Rosini M, Andrisano V, Bartolini M, Bolognesi ML, Hrelia P, Minarini A, Tarozzi A, Melchiorre C. Rational approach to discover multipotent anti-Alzheimer drugs Journal of Medicinal Chemistry. 48: 360-363. PMID 15658850 DOI: 10.1021/Jm049112H |
0.524 |
|
| 2005 |
Bolognesi ML, Andrisano V, Bartolini M, Banzi R, Melchiorre C. Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation. Journal of Medicinal Chemistry. 48: 24-7. PMID 15633997 DOI: 10.1021/Jm049156Q |
0.435 |
|
| 2004 |
Tumiatti V, Andrisano V, Banzi R, Bartolini M, Minarini A, Rosini M, Melchiorre C. Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties. Journal of Medicinal Chemistry. 47: 6490-8. PMID 15588084 DOI: 10.1021/Jm0494366 |
0.523 |
|
| 2004 |
Bolognesi ML, Bartolini M, Cavalli A, Andrisano V, Rosini M, Minarini A, Melchiorre C. Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues. Journal of Medicinal Chemistry. 47: 5945-52. PMID 15537349 DOI: 10.1021/Jm049782N |
0.502 |
|
| 2004 |
Bartolini M, Cavrini V, Andrisano V. Monolithic micro-immobilized-enzyme reactor with human recombinant acetylcholinesterase for on-line inhibition studies Journal of Chromatography A. 1031: 27-34. PMID 15058565 DOI: 10.1016/J.Chroma.2003.11.080 |
0.364 |
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| 2004 |
Cavalli A, Bolognesi ML, Bartolini M, Andrisano V, Melchiorre C, Recanatani M, Margotti E, Capsoni S, Cattaneo A. P1-339 Memoquin: a new therapeutic poly-agent for Alzheimer's disease Neurobiology of Aging. 25: S194. DOI: 10.1016/S0197-4580(04)80652-3 |
0.369 |
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| 2003 |
Bertucci C, Bartolini M, Gotti R, Andrisano V. Drug affinity to immobilized target bio-polymers by high-performance liquid chromatography and capillary electrophoresis Journal of Chromatography B. 797: 111-129. PMID 14630146 DOI: 10.1016/J.Jchromb.2003.08.033 |
0.33 |
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| 2003 |
Bolognesi ML, Cavalli A, Andrisano V, Bartolini M, Banzi R, Antonello A, Rosini M, Melchiorre C. Design, synthesis and biological evaluation of ambenonium derivatives as AChE inhibitors. Farmaco (Societa Chimica Italiana : 1989). 58: 917-28. PMID 13679187 DOI: 10.1016/S0014-827X(03)00150-2 |
0.54 |
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| 2003 |
Piazzi L, Rampa A, Bisi A, Gobbi S, Belluti F, Cavalli A, Bartolini M, Andrisano V, Valenti P, Recanatini M. 3-(4-{[Benzyl(methyl)amino]methyl}phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) Inhibits Both Acetylcholinesterase and Acetylcholinesterase-Induced β-Amyloid Aggregation: A Dual Function Lead for Alzheimer's Disease Therapy§ Journal of Medicinal Chemistry. 46: 2279-2282. PMID 12773032 DOI: 10.1021/Jm0340602 |
0.462 |
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| 2003 |
Tumiatti V, Rosini M, Bartolini M, Cavalli A, Marucci G, Andrisano V, Angeli P, Banzi R, Minarini A, Recanatini M, Melchiorre C. Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine. Journal of Medicinal Chemistry. 46: 954-66. PMID 12620072 DOI: 10.1021/Jm021055+ |
0.475 |
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| 2003 |
Bartolini M, Andrisano V, Wainer IW. Development and characterization of an immobilized enzyme reactor based on glyceraldehyde-3-phosphate dehydrogenase for on-line enzymatic studies. Journal of Chromatography. A. 987: 331-40. PMID 12613827 DOI: 10.1016/S0021-9673(02)01809-5 |
0.318 |
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| 2003 |
Bartolini M, Bertucci C, Cavrini V, Andrisano V. β-Amyloid aggregation induced by human acetylcholinesterase: inhibition studies Biochemical Pharmacology. 65: 407-416. PMID 12527333 DOI: 10.1016/S0006-2952(02)01514-9 |
0.43 |
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| 2002 |
Bartolini M, Bertucci C, Gotti R, Tumiatti V, Cavalli A, Recanatini M, Andrisano V. Determination of the dissociation constants (pKa) of basic acetylcholinesterase inhibitors by reversed-phase liquid chromatography Journal of Chromatography A. 958: 59-67. PMID 12134831 DOI: 10.1016/S0021-9673(02)00385-0 |
0.329 |
|
| 2002 |
Bolognesi ML, Bixel MG, Marucci G, Bartolini M, Krauss M, Angeli P, Antonello A, Rosini M, Tumiatti V, Hucho F, Melchiorre C. Structure-activity relationships of methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists. 3. Effect of inserting the tetraamine backbone into a macrocyclic structure Journal of Medicinal Chemistry. 45: 3286-3295. PMID 12109912 DOI: 10.1021/Jm020835F |
0.431 |
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| 2001 |
Rampa A, Piazzi L, Belluti F, Gobbi S, Bisi A, Bartolini M, Andrisano V, Cavrini V, Cavalli A, Recanatini M, Valenti P. Acetylcholinesterase Inhibitors: SAR and Kinetic Studies on ω-[N-Methyl-N-(3-alkylcarbamoyloxyphenyl)methyl]aminoalkoxyaryl Derivatives Journal of Medicinal Chemistry. 44: 3810-3820. PMID 11689067 DOI: 10.1021/Jm010914B |
0.409 |
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| 2001 |
Andrisano V, Bartolini M, Gotti R, Cavrini V, Felix G. Determination of inhibitors' potency (IC50) by a direct high-performance liquid chromatographic method on an immobilised acetylcholinesterase column. Journal of Chromatography B: Biomedical Sciences and Applications. 753: 375-383. PMID 11334353 DOI: 10.1016/S0378-4347(00)00571-5 |
0.376 |
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| 2001 |
Bolognesi ML, Andrisano V, Bartolini M, Minarini A, Rosini M, Tumiatti V, Melchiorre C. Hexahydrochromeno[4,3-b]pyrrole derivatives as acetylcholinesterase inhibitors. Journal of Medicinal Chemistry. 44: 105-9. PMID 11141093 DOI: 10.1021/Jm000991R |
0.436 |
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| 2000 |
Recanatini M, Cavalli A, Belluti F, Piazzi L, Rampa A, Bisi A, Gobbi S, Valenti P, Andrisano V, Bartolini M, Cavrini V. SAR of 9-Amino-1,2,3,4-tetrahydroacridine-Based Acetylcholinesterase Inhibitors: Synthesis, Enzyme Inhibitory Activity, QSAR, and Structure-Based CoMFA of Tacrine Analogues Journal of Medicinal Chemistry. 43: 2007-2018. PMID 10821713 DOI: 10.1021/Jm990971T |
0.445 |
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