| Year |
Citation |
Score |
| 2021 |
Burrows N, Bashford-Rogers RJM, Bhute VJ, Peñalver A, Ferdinand JR, Stewart BJ, Smith JEG, Deobagkar-Lele M, Giudice G, Connor TM, Inaba A, Bergamaschi L, Smith S, Tran MGB, Petsalaki E, ... ... Maxwell PH, et al. Author Correction: Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development. Nature Immunology. PMID 34522040 DOI: 10.1038/s41590-021-01036-7 |
0.699 |
|
| 2020 |
Bhute VJ, Harte J, Houghton JW, Maxwell PH. Mannose Binding Lectin Is Hydroxylated by Collagen Prolyl-4-hydroxylase and Inhibited by Some PHD Inhibitors. Kidney360. 1: 447-457. PMID 35368589 DOI: 10.34067/KID.0000092020 |
0.676 |
|
| 2020 |
Burrows N, Bashford-Rogers RJM, Bhute VJ, Peñalver A, Ferdinand JR, Stewart BJ, Smith JEG, Deobagkar-Lele M, Giudice G, Connor TM, Inaba A, Bergamaschi L, Smith S, Tran MGB, Petsalaki E, ... ... Maxwell PH, et al. Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development. Nature Immunology. PMID 32868930 DOI: 10.1038/S41590-020-0772-8 |
0.713 |
|
| 2020 |
Bhute VJ, Harte J, Houghton JW, Maxwell PH. Mannose Binding Lectin Is Hydroxylated by Collagen Prolyl-4-hydroxylase and Inhibited by Some PHD Inhibitors Kidney360. 1: 447-457. DOI: 10.34067/Kid.0000092020 |
0.71 |
|
| 2019 |
Stegen S, Laperre K, Eelen G, Rinaldi G, Fraisl P, Torrekens S, Van Looveren R, Loopmans S, Bultynck G, Vinckier S, Meersman F, Maxwell PH, Rai J, Weis M, Eyre DR, et al. HIF-1α metabolically controls collagen synthesis and modification in chondrocytes. Nature. PMID 30651640 DOI: 10.1038/S41586-019-0874-3 |
0.314 |
|
| 2018 |
Briston T, Stephen JM, Thomas LW, Esposito C, Chung YL, Syafruddin SE, Turmaine M, Maddalena LA, Greef B, Szabadkai G, Maxwell PH, Vanharanta S, Ashcroft M. VHL-Mediated Regulation of CHCHD4 and Mitochondrial Function. Frontiers in Oncology. 8: 388. PMID 30338240 DOI: 10.3389/Fonc.2018.00388 |
0.358 |
|
| 2018 |
Young MD, Mitchell TJ, Vieira Braga FA, Tran MGB, Stewart BJ, Ferdinand JR, Collord G, Botting RA, Popescu DM, Loudon KW, Vento-Tormo R, Stephenson E, Cagan A, Farndon SJ, Del Castillo Velasco-Herrera M, ... ... Maxwell PH, et al. Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors. Science (New York, N.Y.). 361: 594-599. PMID 30093597 DOI: 10.1126/Science.Aat1699 |
0.326 |
|
| 2017 |
Horton SJ, Giotopoulos G, Yun H, Vohra S, Sheppard O, Bashford-Rogers R, Rashid M, Clipson A, Chan WI, Sasca D, Yiangou L, Osaki H, Basheer F, Gallipoli P, Burrows N, ... ... Maxwell P, et al. Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors. Nature Cell Biology. PMID 28825697 DOI: 10.1038/Ncb3597 |
0.308 |
|
| 2017 |
Sadiku P, Willson JA, Dickinson RS, Murphy F, Harris AJ, Lewis A, Sammut D, Mirchandani AS, Ryan E, Watts ER, Thompson AAR, Marriott HM, Dockrell DH, Taylor CT, Schneider M, ... Maxwell PH, et al. Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses. The Journal of Clinical Investigation. PMID 28805660 DOI: 10.1172/Jci90848 |
0.304 |
|
| 2017 |
Kiriakidis S, Hoer SS, Burrows N, Biddlecome G, Khan MN, Thinnes CC, Schofield CJ, Rogers N, Botto M, Paleolog E, Maxwell PH. Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia-inducible factor. Kidney International. PMID 28506759 DOI: 10.1016/J.Kint.2017.03.008 |
0.353 |
|
| 2017 |
Talbot NP, Smith TG, Balanos GM, Dorrington KL, Maxwell PH, Robbins PA. Cardiopulmonary phenotype associated with human PHD2 mutation. Physiological Reports. 5. PMID 28400504 DOI: 10.14814/Phy2.13224 |
0.366 |
|
| 2017 |
Burrows N, Maxwell PH. Hypoxia and B cells. Experimental Cell Research. PMID 28300562 DOI: 10.1016/J.Yexcr.2017.03.019 |
0.354 |
|
| 2016 |
Sciacovelli M, Gonçalves E, Johnson TI, Zecchini VR, da Costa AS, Gaude E, Drubbel AV, Theobald SJ, Abbo SR, Tran MG, Rajeeve V, Cardaci S, Foster S, Yun H, Cutillas P, ... ... Maxwell PH, et al. Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition. Nature. PMID 27580029 DOI: 10.1038/Nature19353 |
0.341 |
|
| 2016 |
Al-Lamki RS, Wang J, Yang J, Burrows N, Maxwell PH, Eisen T, Warren AY, Vanharanta S, Pacey S, Vandenabeele P, Pober JS, Bradley JR. Tumor necrosis factor receptor 2-signaling in CD133-expressing cells in renal clear cell carcinoma. Oncotarget. PMID 26992212 DOI: 10.18632/Oncotarget.8125 |
0.343 |
|
| 2016 |
Burrows N, Cane G, Robson M, Gaude E, J Howat W, Szlosarek PW, Pedley RB, Frezza C, Ashcroft M, Maxwell PH. Hypoxia-induced nitric oxide production and tumour perfusion is inhibited by pegylated arginine deiminase (ADI-PEG20). Scientific Reports. 6: 22950. PMID 26972697 DOI: 10.1038/Srep22950 |
0.351 |
|
| 2016 |
Stegen S, van Gastel N, Eelen G, Ghesquière B, D'Anna F, Thienpont B, Goveia J, Torrekens S, Van Looveren R, Luyten FP, Maxwell PH, Wielockx B, Lambrechts D, Fendt SM, Carmeliet P, et al. HIF-1α Promotes Glutamine-Mediated Redox Homeostasis and Glycogen-Dependent Bioenergetics to Support Postimplantation Bone Cell Survival. Cell Metabolism. 23: 265-79. PMID 26863487 DOI: 10.1016/J.Cmet.2016.01.002 |
0.333 |
|
| 2015 |
Maxwell PH, Eckardt KU. HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond. Nature Reviews. Nephrology. PMID 26656456 DOI: 10.1038/Nrneph.2015.193 |
0.314 |
|
| 2014 |
Tian W, Wang Y, Xu Y, Guo X, Wang B, Sun L, Liu L, Cui F, Zhuang Q, Bao X, Schley G, Chung TL, Laslett AL, Willam C, Qin B, ... Maxwell PH, et al. The hypoxia-inducible factor renders cancer cells more sensitive to vitamin C-induced toxicity. The Journal of Biological Chemistry. 289: 3339-51. PMID 24371136 DOI: 10.1074/Jbc.M113.538157 |
0.338 |
|
| 2013 |
Yang OC, Maxwell PH, Pollard PJ. Renal cell carcinoma: translational aspects of metabolism and therapeutic consequences. Kidney International. 84: 667-81. PMID 23823604 DOI: 10.1038/Ki.2013.245 |
0.306 |
|
| 2013 |
Barriga EH, Maxwell PH, Reyes AE, Mayor R. The hypoxia factor Hif-1α controls neural crest chemotaxis and epithelial to mesenchymal transition. The Journal of Cell Biology. 201: 759-76. PMID 23712262 DOI: 10.1083/Jcb.201212100 |
0.327 |
|
| 2013 |
Luong le A, Fragiadaki M, Smith J, Boyle J, Lutz J, Dean JL, Harten S, Ashcroft M, Walmsley SR, Haskard DO, Maxwell PH, Walczak H, Pusey C, Evans PC. Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination. Circulation Research. 112: 1583-91. PMID 23564640 DOI: 10.1161/Circresaha.111.300119 |
0.359 |
|
| 2013 |
Gale DP, Maxwell PH. C3 glomerulonephritis and CFHR5 nephropathy. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. 28: 282-8. PMID 23125424 DOI: 10.1093/Ndt/Gfs441 |
0.31 |
|
| 2012 |
Lange CA, Luhmann UF, Mowat FM, Georgiadis A, West EL, Abrahams S, Sayed H, Powner MB, Fruttiger M, Smith AJ, Sowden JC, Maxwell PH, Ali RR, Bainbridge JW. Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development. Development (Cambridge, England). 139: 2340-50. PMID 22627278 DOI: 10.1242/Dev.070813 |
0.318 |
|
| 2012 |
Schietke RE, Hackenbeck T, Tran M, Günther R, Klanke B, Warnecke CL, Knaup KX, Shukla D, Rosenberger C, Koesters R, Bachmann S, Betz P, Schley G, Schödel J, Willam C, ... ... Maxwell P, et al. Renal tubular HIF-2α expression requires VHL inactivation and causes fibrosis and cysts. Plos One. 7: e31034. PMID 22299048 DOI: 10.1371/Journal.Pone.0031034 |
0.352 |
|
| 2012 |
Yang J, Staples O, Thomas LW, Briston T, Robson M, Poon E, Simões ML, El-Emir E, Buffa FM, Ahmed A, Annear NP, Shukla D, Pedley BR, Maxwell PH, Harris AL, et al. Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression. The Journal of Clinical Investigation. 122: 600-11. PMID 22214851 DOI: 10.1172/Jci58780 |
0.347 |
|
| 2012 |
Xu J, Wang B, Xu Y, Sun L, Tian W, Shukla D, Barod R, Grillari J, Grillari-Voglauer R, Maxwell PH, Esteban MA. Epigenetic regulation of HIF-1α in renal cancer cells involves HIF-1α/2α binding to a reverse hypoxia-response element. Oncogene. 31: 1065-72. PMID 21841824 DOI: 10.1038/Onc.2011.305 |
0.32 |
|
| 2011 |
Adam J, Hatipoglu E, O'Flaherty L, Ternette N, Sahgal N, Lockstone H, Baban D, Nye E, Stamp GW, Wolhuter K, Stevens M, Fischer R, Carmeliet P, Maxwell PH, Pugh CW, et al. Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling. Cancer Cell. 20: 524-37. PMID 22014577 DOI: 10.1016/J.Ccr.2011.09.006 |
0.363 |
|
| 2011 |
Takeda Y, Costa S, Delamarre E, Roncal C, Leite de Oliveira R, Squadrito ML, Finisguerra V, Deschoemaeker S, Bruyère F, Wenes M, Hamm A, Serneels J, Magat J, Bhattacharyya T, Anisimov A, ... ... Maxwell P, et al. Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis. Nature. 479: 122-6. PMID 21983962 DOI: 10.1038/Nature10507 |
0.3 |
|
| 2011 |
Schley G, Klanke B, Schödel J, Forstreuter F, Shukla D, Kurtz A, Amann K, Wiesener MS, Rosen S, Eckardt KU, Maxwell PH, Willam C. Hypoxia-inducible transcription factors stabilization in the thick ascending limb protects against ischemic acute kidney injury. Journal of the American Society of Nephrology : Jasn. 22: 2004-15. PMID 21921145 DOI: 10.1681/Asn.2010121249 |
0.341 |
|
| 2011 |
Maxwell PH. Seeing the smoking gun: a sensitive and specific method to visualize loss of the tumour suppressor, fumarate hydratase, in human tissues. The Journal of Pathology. 225: 1-3. PMID 21792933 DOI: 10.1002/Path.2950 |
0.306 |
|
| 2011 |
Harten SK, Esteban MA, Shukla D, Ashcroft M, Maxwell PH. Inactivation of the von Hippel-Lindau tumour suppressor gene induces Neuromedin U expression in renal cancer cells. Molecular Cancer. 10: 89. PMID 21791076 DOI: 10.1186/1476-4598-10-89 |
0.339 |
|
| 2011 |
Formenti F, Beer PA, Croft QP, Dorrington KL, Gale DP, Lappin TR, Lucas GS, Maher ER, Maxwell PH, McMullin MF, O'Connor DF, Percy MJ, Pugh CW, Ratcliffe PJ, Smith TG, et al. Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2alpha gain-of-function mutation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 2001-11. PMID 21389259 DOI: 10.1096/Fj.10-177378 |
0.338 |
|
| 2011 |
Khan MN, Bhattacharyya T, Andrikopoulos P, Esteban MA, Barod R, Connor T, Ashcroft M, Maxwell PH, Kiriakidis S. Factor inhibiting HIF (FIH-1) promotes renal cancer cell survival by protecting cells from HIF-1α-mediated apoptosis. British Journal of Cancer. 104: 1151-9. PMID 21386837 DOI: 10.1038/Bjc.2011.73 |
0.374 |
|
| 2011 |
Walmsley SR, Chilvers ER, Thompson AA, Vaughan K, Marriott HM, Parker LC, Shaw G, Parmar S, Schneider M, Sabroe I, Dockrell DH, Milo M, Taylor CT, Johnson RS, Pugh CW, ... ... Maxwell PH, et al. Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice. The Journal of Clinical Investigation. 121: 1053-63. PMID 21317538 DOI: 10.1172/Jci43273 |
0.348 |
|
| 2011 |
Bou-Gharios G, Amin F, Hill P, Nakamura H, Maxwell P, Fisk NM. Microchimeric fetal cells are recruited to maternal kidney following injury and activate collagen type I transcription. Cells, Tissues, Organs. 193: 379-92. PMID 21150166 DOI: 10.1159/000321172 |
0.306 |
|
| 2010 |
Cantley J, Grey ST, Maxwell PH, Withers DJ. The hypoxia response pathway and β-cell function Diabetes, Obesity and Metabolism. 12: 159-167. PMID 21029313 DOI: 10.1111/J.1463-1326.2010.01276.X |
0.317 |
|
| 2010 |
Ashrafian H, O'Flaherty L, Adam J, Steeples V, Chung YL, East P, Vanharanta S, Lehtonen H, Nye E, Hatipoglu E, Miranda M, Howarth K, Shukla D, Troy H, Griffiths J, ... ... Maxwell PH, et al. Expression profiling in progressive stages of fumarate-hydratase deficiency: the contribution of metabolic changes to tumorigenesis. Cancer Research. 70: 9153-65. PMID 20978192 DOI: 10.1158/0008-5472.Can-10-1949 |
0.376 |
|
| 2010 |
Xu J, Li H, Wang B, Xu Y, Yang J, Zhang X, Harten SK, Shukla D, Maxwell PH, Pei D, Esteban MA. VHL inactivation induces HEF1 and Aurora kinase A. Journal of the American Society of Nephrology : Jasn. 21: 2041-6. PMID 20864688 DOI: 10.1681/Asn.2010040345 |
0.327 |
|
| 2010 |
Gale DP, de Jorge EG, Cook HT, Martinez-Barricarte R, Hadjisavvas A, McLean AG, Pusey CD, Pierides A, Kyriacou K, Athanasiou Y, Voskarides K, Deltas C, Palmer A, Frémeaux-Bacchi V, de Cordoba SR, ... Maxwell PH, et al. Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with glomerulonephritis. Lancet (London, England). 376: 794-801. PMID 20800271 DOI: 10.1016/S0140-6736(10)60670-8 |
0.305 |
|
| 2010 |
Tambuwala MM, Cummins EP, Lenihan CR, Kiss J, Stauch M, Scholz CC, Fraisl P, Lasitschka F, Mollenhauer M, Saunders SP, Maxwell PH, Carmeliet P, Fallon PG, Schneider M, Taylor CT. Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function. Gastroenterology. 139: 2093-101. PMID 20600011 DOI: 10.1053/J.Gastro.2010.06.068 |
0.335 |
|
| 2010 |
Mowat FM, Luhmann UF, Smith AJ, Lange C, Duran Y, Harten S, Shukla D, Maxwell PH, Ali RR, Bainbridge JW. HIF-1alpha and HIF-2alpha are differentially activated in distinct cell populations in retinal ischaemia. Plos One. 5: e11103. PMID 20559438 DOI: 10.1371/Journal.Pone.0011103 |
0.344 |
|
| 2010 |
Gale DP, Maxwell PH. The role of HIF in immunity. The International Journal of Biochemistry & Cell Biology. 42: 486-94. PMID 19840863 DOI: 10.1016/J.Biocel.2009.10.012 |
0.314 |
|
| 2010 |
Harten SK, Ashcroft M, Maxwell PH. Prolyl hydroxylase domain inhibitors: a route to HIF activation and neuroprotection. Antioxidants & Redox Signaling. 12: 459-80. PMID 19737089 DOI: 10.1089/Ars.2009.2870 |
0.321 |
|
| 2009 |
Tuthill M, Barod R, Pyle L, Cook T, Chew S, Gore M, Maxwell P, Eisen T. A report of succinate dehydrogenase B deficiency associated with metastatic papillary renal cell carcinoma: successful treatment with the multi-targeted tyrosine kinase inhibitor sunitinib. Bmj Case Reports. 2009. PMID 21686655 DOI: 10.1136/Bcr.08.2008.0732 |
0.319 |
|
| 2009 |
Volke M, Gale DP, Maegdefrau U, Schley G, Klanke B, Bosserhoff AK, Maxwell PH, Eckardt KU, Warnecke C. Evidence for a lack of a direct transcriptional suppression of the iron regulatory peptide hepcidin by hypoxia-inducible factors. Plos One. 4: e7875. PMID 19924283 DOI: 10.1371/Journal.Pone.0007875 |
0.343 |
|
| 2009 |
Wiesener MS, Maxwell PH, Eckardt KU. Novel insights into the role of the tumor suppressor von Hippel Lindau in cellular differentiation, ciliary biology, and cyst repression. Journal of Molecular Medicine (Berlin, Germany). 87: 871-7. PMID 19629420 DOI: 10.1007/S00109-009-0504-X |
0.341 |
|
| 2009 |
Ebbesen P, Pettersen EO, Gorr TA, Jobst G, Williams K, Kieninger J, Wenger RH, Pastorekova S, Dubois L, Lambin P, Wouters BG, Van Den Beucken T, Supuran CT, Poellinger L, Ratcliffe P, ... ... Maxwell P, et al. Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies. Journal of Enzyme Inhibition and Medicinal Chemistry. 24: 1-39. PMID 19330638 DOI: 10.1080/14756360902784425 |
0.335 |
|
| 2009 |
Mazzone M, Dettori D, Leite de Oliveira R, Loges S, Schmidt T, Jonckx B, Tian YM, Lanahan AA, Pollard P, Ruiz de Almodovar C, De Smet F, Vinckier S, Aragonés J, Debackere K, Luttun A, ... ... Maxwell P, et al. Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization. Cell. 136: 839-51. PMID 19217150 DOI: 10.1016/J.Cell.2009.01.020 |
0.319 |
|
| 2009 |
Harten SK, Esteban MA, Maxwell PH. Identification of novel VHL regulated genes by transcriptomic analysis of RCC10 renal carcinoma cells. Advances in Enzyme Regulation. 49: 43-52. PMID 19162062 DOI: 10.1016/J.Advenzreg.2008.12.005 |
0.313 |
|
| 2009 |
Ma D, Lim T, Xu J, Tang H, Wan Y, Zhao H, Hossain M, Maxwell PH, Maze M. Xenon preconditioning protects against renal ischemic-reperfusion injury via HIF-1alpha activation. Journal of the American Society of Nephrology : Jasn. 20: 713-20. PMID 19144758 DOI: 10.1681/Asn.2008070712 |
0.321 |
|
| 2009 |
Harten SK, Shukla D, Barod R, Hergovich A, Balda MS, Matter K, Esteban MA, Maxwell PH. Regulation of renal epithelial tight junctions by the von Hippel-Lindau tumor suppressor gene involves occludin and claudin 1 and is independent of E-cadherin. Molecular Biology of the Cell. 20: 1089-101. PMID 19073886 DOI: 10.1091/Mbc.E08-06-0566 |
0.367 |
|
| 2009 |
Brooks JT, Elvidge GP, Glenny L, Gleadle JM, Liu C, Ragoussis J, Smith TG, Talbot NP, Winchester L, Maxwell PH, Robbins PA. Variations within oxygen-regulated gene expression in humans. Journal of Applied Physiology (Bethesda, Md. : 1985). 106: 212-20. PMID 19008490 DOI: 10.1152/Japplphysiol.90578.2008 |
0.331 |
|
| 2008 |
Mehta GU, Shively SB, Duong H, Tran MG, Moncrief TJ, Smith JH, Li J, Edwards NA, Lonser RR, Zhuang Z, Merrill MJ, Raffeld M, Maxwell PH, Oldfield EH, Vortmeyer AO. Progression of epididymal maldevelopment into hamartoma-like neoplasia in VHL disease. Neoplasia (New York, N.Y.). 10: 1146-53. PMID 18813354 DOI: 10.1593/Neo.08476 |
0.344 |
|
| 2008 |
Gale DP, Harten SK, Reid CD, Tuddenham EG, Maxwell PH. Autosomal dominant erythrocytosis and pulmonary arterial hypertension associated with an activating HIF2 alpha mutation. Blood. 112: 919-21. PMID 18650473 DOI: 10.1182/Blood-2008-04-153718 |
0.334 |
|
| 2008 |
Bishop T, Gallagher D, Pascual A, Lygate CA, de Bono JP, Nicholls LG, Ortega-Saenz P, Oster H, Wijeyekoon B, Sutherland AI, Grosfeld A, Aragones J, Schneider M, van Geyte K, Teixeira D, ... ... Maxwell PH, et al. Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice. Molecular and Cellular Biology. 28: 3386-400. PMID 18332118 DOI: 10.1128/Mcb.02041-07 |
0.332 |
|
| 2008 |
Mikhaylova O, Ignacak ML, Barankiewicz TJ, Harbaugh SV, Yi Y, Maxwell PH, Schneider M, Van Geyte K, Carmeliet P, Revelo MP, Wyder M, Greis KD, Meller J, Czyzyk-Krzeska MF. The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress. Molecular and Cellular Biology. 28: 2701-17. PMID 18285459 DOI: 10.1128/Mcb.01231-07 |
0.33 |
|
| 2008 |
Angelillo-Scherrer A, Burnier L, Lambrechts D, Fish RJ, Tjwa M, Plaisance S, Sugamele R, DeMol M, Martinez-Soria E, Maxwell PH, Lemke G, Goff SP, Matsushima GK, Earp HS, Chanson M, et al. Role of Gas6 in erythropoiesis and anemia in mice. The Journal of Clinical Investigation. 118: 583-96. PMID 18188450 DOI: 10.1172/Jci30375 |
0.319 |
|
| 2008 |
Hill P, Shukla D, Tran MG, Aragones J, Cook HT, Carmeliet P, Maxwell PH. Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury. Journal of the American Society of Nephrology : Jasn. 19: 39-46. PMID 18178798 DOI: 10.1681/Asn.2006090998 |
0.317 |
|
| 2008 |
Aragonés J, Schneider M, Van Geyte K, Fraisl P, Dresselaers T, Mazzone M, Dirkx R, Zacchigna S, Lemieux H, Jeoung NH, Lambrechts D, Bishop T, Lafuste P, Diez-Juan A, Harten SK, ... ... Maxwell P, et al. Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism. Nature Genetics. 40: 170-80. PMID 18176562 DOI: 10.1038/Ng.2007.62 |
0.318 |
|
| 2007 |
Rajatapiti P, van der Horst IW, de Rooij JD, Tran MG, Maxwell PH, Tibboel D, Rottier R, de Krijger RR. Expression of hypoxia-inducible factors in normal human lung development. Pediatric and Developmental Pathology : the Official Journal of the Society For Pediatric Pathology and the Paediatric Pathology Society. 11: 193-9. PMID 17990921 DOI: 10.2350/07-04-0257.1 |
0.303 |
|
| 2007 |
Wiesener MS, Münchenhagen P, Gläser M, Sobottka BA, Knaup KX, Jozefowski K, Jürgensen JS, Roigas J, Warnecke C, Gröne HJ, Maxwell PH, Willam C, Eckardt KU. Erythropoietin gene expression in renal carcinoma is considerably more frequent than paraneoplastic polycythemia. International Journal of Cancer. 121: 2434-42. PMID 17640059 DOI: 10.1002/Ijc.22961 |
0.383 |
|
| 2007 |
Pollard PJ, Spencer-Dene B, Shukla D, Howarth K, Nye E, El-Bahrawy M, Deheragoda M, Joannou M, McDonald S, Martin A, Igarashi P, Varsani-Brown S, Rosewell I, Poulsom R, Maxwell P, et al. Targeted Inactivation of Fh1 Causes Proliferative Renal Cyst Development and Activation of the Hypoxia Pathway Cancer Cell. 11: 311-319. PMID 17418408 DOI: 10.1016/J.Ccr.2007.02.005 |
0.357 |
|
| 2007 |
Boutet A, Esteban MA, Maxwell PH, Nieto MA. Reactivation of Snail genes in renal fibrosis and carcinomas: a process of reversed embryogenesis? Cell Cycle (Georgetown, Tex.). 6: 638-42. PMID 17374993 DOI: 10.4161/Cc.6.6.4022 |
0.317 |
|
| 2007 |
Kiriakidis S, Esteban MA, Maxwell PH. Genetic insights into the hypoxia-inducible factor (HIF) pathway. Advances in Enzyme Regulation. 47: 288-306. PMID 17335877 DOI: 10.1016/J.Advenzreg.2006.12.009 |
0.304 |
|
| 2007 |
Zwerts F, Lupu F, De Vriese A, Pollefeyt S, Moons L, Altura RA, Jiang Y, Maxwell PH, Hill P, Oh H, Rieker C, Collen D, Conway SJ, Conway EM. Lack of endothelial cell survivin causes embryonic defects in angiogenesis, cardiogenesis, and neural tube closure Blood. 109: 4742-4752. PMID 17299096 DOI: 10.1182/Blood-2006-06-028068 |
0.303 |
|
| 2006 |
Boutet A, De Frutos CA, Maxwell PH, Mayol MJ, Romero J, Nieto MA. Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney. The Embo Journal. 25: 5603-13. PMID 17093497 DOI: 10.1038/Sj.Emboj.7601421 |
0.327 |
|
| 2006 |
Vortmeyer AO, Tran MG, Zeng W, Gläsker S, Riley C, Tsokos M, Ikejiri B, Merrill MJ, Raffeld M, Zhuang Z, Lonser RR, Maxwell PH, Oldfield EH. Evolution of VHL tumourigenesis in nerve root tissue. The Journal of Pathology. 210: 374-82. PMID 16981244 DOI: 10.1002/Path.2062 |
0.318 |
|
| 2006 |
Gläsker S, Tran MG, Shively SB, Ikejiri B, Lonser RR, Maxwell PH, Zhuang Z, Oldfield EH, Vortmeyer AO. Epididymal cystadenomas and epithelial tumourlets: effects of VHL deficiency on the human epididymis. The Journal of Pathology. 210: 32-41. PMID 16841375 DOI: 10.1002/Path.2029 |
0.365 |
|
| 2006 |
Walmsley SR, Cowburn AS, Clatworthy MR, Morrell NW, Roper EC, Singleton V, Maxwell P, Whyte MKB, Chilvers ER. Neutrophils from patients with heterozygous germline mutations in the von Hippel Lindau protein (pVHL) display delayed apoptosis and enhanced bacterial phagocytosis Blood. 108: 3176-3178. PMID 16809612 DOI: 10.1182/Blood-2006-04-018796 |
0.349 |
|
| 2006 |
Koumenis C, Maxwell PH. Low oxygen stimulates the intellect. Symposium on hypoxia and development, physiology and disease. Embo Reports. 7: 679-84. PMID 16799463 DOI: 10.1038/Sj.Embor.7400733 |
0.369 |
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| 2006 |
Esteban MA, Harten SK, Tran MG, Maxwell PH. Formation of primary cilia in the renal epithelium is regulated by the von Hippel-Lindau tumor suppressor protein. Journal of the American Society of Nephrology : Jasn. 17: 1801-6. PMID 16775032 DOI: 10.1681/Asn.2006020181 |
0.336 |
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| 2006 |
Smith TG, Brooks JT, Balanos GM, Lappin TR, Layton DM, Leedham DL, Liu C, Maxwell PH, McMullin MF, McNamara CJ, Percy MJ, Pugh CW, Ratcliffe PJ, Talbot NP, Treacy M, et al. Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology. Plos Medicine. 3: e290. PMID 16768548 DOI: 10.1371/Journal.Pmed.0030290 |
0.335 |
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| 2006 |
Esteban MA, Tran MG, Harten SK, Hill P, Castellanos MC, Chandra A, Raval R, O'brien TS, Maxwell PH. Regulation of E-cadherin expression by VHL and hypoxia-inducible factor. Cancer Research. 66: 3567-75. PMID 16585181 DOI: 10.1158/0008-5472.Can-05-2670 |
0.371 |
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| 2006 |
Percy MJ, Zhao Q, Flores A, Harrison C, Lappin TR, Maxwell PH, McMullin MF, Lee FS. A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 103: 654-9. PMID 16407130 DOI: 10.1073/Pnas.0508423103 |
0.38 |
|
| 2006 |
Esteban MA, Maxwell PH. Manipulation of oxygen tensions for in vitro cell culture using a hypoxic workstation. Expert Review of Proteomics. 2: 307-14. PMID 16000078 DOI: 10.1586/14789450.2.3.307 |
0.314 |
|
| 2005 |
Gläsker S, Lonser RR, Tran MG, Ikejiri B, Butman JA, Zeng W, Maxwell PH, Zhuang Z, Oldfield EH, Vortmeyer AO. Effects of VHL deficiency on endolymphatic duct and sac. Cancer Research. 65: 10847-53. PMID 16322231 DOI: 10.1158/0008-5472.Can-05-1104 |
0.307 |
|
| 2005 |
Maxwell PH. Hypoxia-inducible factor as a physiological regulator Experimental Physiology. 90: 791-797. PMID 16157658 DOI: 10.1113/Expphysiol.2005.030924 |
0.36 |
|
| 2005 |
Maxwell PH. The HIF pathway in cancer Seminars in Cell and Developmental Biology. 16: 523-530. PMID 16144689 DOI: 10.1016/J.Semcdb.2005.03.001 |
0.338 |
|
| 2005 |
Acker T, Diez-Juan A, Aragones J, Tjwa M, Brusselmans K, Moons L, Fukumura D, Moreno-Murciano MP, Herbert JM, Burger A, Riedel J, Elvert G, Flamme I, Maxwell PH, Collen D, et al. Genetic evidence for a tumor suppressor role of HIF-2alpha. Cancer Cell. 8: 131-41. PMID 16098466 DOI: 10.1016/J.Ccr.2005.07.003 |
0.326 |
|
| 2005 |
Raval RR, Lau KW, Tran MG, Sowter HM, Mandriota SJ, Li JL, Pugh CW, Maxwell PH, Harris AL, Ratcliffe PJ. Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. Molecular and Cellular Biology. 25: 5675-86. PMID 15964822 DOI: 10.1128/Mcb.25.13.5675-5686.2005 |
0.334 |
|
| 2005 |
Willam C, Nicholls LG, Ratcliffe PJ, Pugh CW, Maxwell PH. The prolyl hydroxylase enzymes that act as oxygen sensors regulating destruction of hypoxia-inducible factor alpha. Advances in Enzyme Regulation. 44: 75-92. PMID 15581484 DOI: 10.1016/J.Advenzreg.2003.11.017 |
0.313 |
|
| 2005 |
Percy MJ, Zhao Q, Flores A, Harrison CN, Lappin TR, Maxwell PH, McMullin MF, Lee FS. Familial Erythrocytosis Associated with a Mutation in the HIF Prolyl Hydroxylase, PHD2. Blood. 106: 127-127. DOI: 10.1182/Blood.V106.11.127.127 |
0.384 |
|
| 2004 |
Jürgensen JS, Rosenberger C, Wiesener MS, Warnecke C, Hörstrup JH, Gräfe M, Philipp S, Griethe W, Maxwell PH, Frei U, Bachmann S, Willenbrock R, Eckardt KU. Persistent induction of HIF-1alpha and -2alpha in cardiomyocytes and stromal cells of ischemic myocardium. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1415-7. PMID 15247145 DOI: 10.1096/Fj.04-1605Fje |
0.331 |
|
| 2004 |
Kaufman B, Scharf O, Arbeit J, Ashcroft M, Brown JM, Bruick RK, Chapman JD, Evans SM, Giaccia AJ, Harris AL, Huang E, Johnson R, Kaelin W, Koch CJ, Maxwell P, et al. Proceedings of the Oxygen Homeostasis/Hypoxia Meeting. Cancer Research. 64: 3350-6. PMID 15126380 DOI: 10.1158/0008-5472.Can-03-2611 |
0.302 |
|
| 2004 |
Wykoff CC, Sotiriou C, Cockman ME, Ratcliffe PJ, Maxwell P, Liu E, Harris AL. Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene. British Journal of Cancer. 90: 1235-43. PMID 15026807 DOI: 10.1038/Sj.Bjc.6601657 |
0.371 |
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| 2004 |
Maxwell P, Salnikow K. HIF-1: an oxygen and metal responsive transcription factor. Cancer Biology & Therapy. 3: 29-35. PMID 14726713 DOI: 10.4161/Cbt.3.1.547 |
0.343 |
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| 2004 |
Maxwell P. HIF-1’s Relationship to Oxygen: Simple yet Sophisticated Cell Cycle. 3: 151-154. DOI: 10.4161/Cc.3.2.616 |
0.33 |
|
| 2003 |
Wiesener MS, Jürgensen JS, Rosenberger C, Scholze CK, Hörstrup JH, Warnecke C, Mandriota S, Bechmann I, Frei UA, Pugh CW, Ratcliffe PJ, Bachmann S, Maxwell PH, Eckardt KU. Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 271-3. PMID 12490539 DOI: 10.1096/Fj.02-0445Fje |
0.351 |
|
| 2003 |
Maxwell PH. Oxygen homeostasis and cancer: insights from a rare disease. Clinical Medicine (London, England). 2: 356-62. PMID 12195866 DOI: 10.7861/Clinmedicine.2-4-356 |
0.361 |
|
| 2002 |
Ang SO, Chen H, Hirota K, Gordeuk VR, Jelinek J, Guan Y, Liu E, Sergueeva AI, Miasnikova GY, Mole D, Maxwell PH, Stockton DW, Semenza GL, Prchal JT. Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia Nature Genetics. 32: 614-621. PMID 12415268 DOI: 10.1038/Ng1019 |
0.32 |
|
| 2002 |
Binley K, Askham Z, Iqball S, Spearman H, Martin L, de Alwis M, Thrasher AJ, Ali RR, Maxwell PH, Kingsman S, Naylor S. Long-term reversal of chronic anemia using a hypoxia-regulated erythropoietin gene therapy. Blood. 100: 2406-13. PMID 12239150 DOI: 10.1182/Blood-2002-02-0605 |
0.315 |
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| 2002 |
Willam C, Masson N, Tian YM, Mahmood SA, Wilson MI, Bicknell R, Eckardt KU, Maxwell PH, Ratcliffe PJ, Pugh CW. Peptide blockade of HIFalpha degradation modulates cellular metabolism and angiogenesis. Proceedings of the National Academy of Sciences of the United States of America. 99: 10423-8. PMID 12149454 DOI: 10.1073/Pnas.162119399 |
0.35 |
|
| 2002 |
Mandriota SJ, Turner KJ, Davies DR, Murray PG, Morgan NV, Sowter HM, Wykoff CC, Maher ER, Harris AL, Ratcliffe PJ, Maxwell PH. HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron. Cancer Cell. 1: 459-68. PMID 12124175 DOI: 10.1016/S1535-6108(02)00071-5 |
0.368 |
|
| 2002 |
Mole DR, Pugh CW, Ratcliffe PJ, Maxwell PH. Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex. Advances in Enzyme Regulation. 42: 333-47. PMID 12123724 DOI: 10.1016/S0065-2571(01)00037-1 |
0.316 |
|
| 2002 |
Rosenberger C, Mandriota S, Jürgensen JS, Wiesener MS, Hörstrup JH, Frei U, Ratcliffe PJ, Maxwell PH, Bachmann S, Eckardt KU. Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys. Journal of the American Society of Nephrology : Jasn. 13: 1721-32. PMID 12089367 DOI: 10.1097/01.Asn.0000017223.49823.2A |
0.365 |
|
| 2002 |
Hon WC, Wilson MI, Harlos K, Claridge TD, Schofield CJ, Pugh CW, Maxwell PH, Ratcliffe PJ, Stuart DI, Jones EY. Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL. Nature. 417: 975-8. PMID 12050673 DOI: 10.1038/Nature00767 |
0.329 |
|
| 2002 |
McNeill LA, Hewitson KS, Gleadle JM, Horsfall LE, Oldham NJ, Maxwell PH, Pugh CW, Ratcliffe PJ, Schofield CJ. The use of dioxygen by HIF prolyl hydroxylase (PHD1). Bioorganic & Medicinal Chemistry Letters. 12: 1547-50. PMID 12039559 DOI: 10.1016/S0960-894X(02)00219-6 |
0.306 |
|
| 2002 |
Maxwell PH, Ratcliffe PJ. Oxygen sensors and angiogenesis. Seminars in Cell & Developmental Biology. 13: 29-37. PMID 11969369 DOI: 10.1006/Scdb.2001.0287 |
0.362 |
|
| 2002 |
Mole DR, Maxwell PH, Pugh CW, Ratcliffe PJ. Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing. Iubmb Life. 52: 43-7. PMID 11795592 DOI: 10.1080/15216540252774757 |
0.341 |
|
| 2002 |
Pugh C, Maxwell P, Ratcliffe P. Oxygen mediated gene regulation Nephrology. 7: S21-S25. DOI: 10.1046/J.1440-1797.7.S.14.X |
0.371 |
|
| 2001 |
Wykoff CC, Pugh CW, Harris AL, Maxwell PH, Ratcliffe PJ. The HIF pathway: implications for patterns of gene expression in cancer. Novartis Foundation Symposium. 240: 212-25; discussion 2. PMID 11727931 DOI: 10.1002/0470868716.Ch15 |
0.394 |
|
| 2001 |
Pugh CW, Gleadle J, Maxwell PH. Hypoxia and oxidative stress in breast cancer. Hypoxia signalling pathways. Breast Cancer Research : Bcr. 3: 313-7. PMID 11597320 DOI: 10.1186/Bcr313 |
0.351 |
|
| 2001 |
Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, ... ... Maxwell PH, et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell. 107: 43-54. PMID 11595184 DOI: 10.1016/S0092-8674(01)00507-4 |
0.352 |
|
| 2001 |
Masson N, Willam C, Maxwell PH, Pugh CW, Ratcliffe PJ. Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation. The Embo Journal. 20: 5197-206. PMID 11566883 DOI: 10.1093/Emboj/20.18.5197 |
0.34 |
|
| 2001 |
Vaux EC, Wood SM, Cockman ME, Nicholls LG, Yeates KM, Pugh CW, Maxwell PH, Ratcliffe PJ. Selection of mutant CHO cells with constitutive activation of the HIF system and inactivation of the von Hippel-Lindau tumor suppressor. The Journal of Biological Chemistry. 276: 44323-30. PMID 11555645 DOI: 10.1074/Jbc.M104678200 |
0.392 |
|
| 2001 |
Brusselmans K, Bono F, Maxwell P, Dor Y, Dewerchin M, Collen D, Herbert JM, Carmeliet P. Hypoxia-inducible factor-2alpha (HIF-2alpha) is involved in the apoptotic response to hypoglycemia but not to hypoxia. The Journal of Biological Chemistry. 276: 39192-6. PMID 11546756 DOI: 10.1074/Jbc.C100428200 |
0.317 |
|
| 2001 |
Clifford SC, Astuti D, Hooper L, Maxwell PH, Ratcliffe PJ, Maher ER. The pVHL-associated SCF ubiquitin ligase complex: molecular genetic analysis of elongin B and C, Rbx1 and HIF-1alpha in renal cell carcinoma. Oncogene. 20: 5067-74. PMID 11526493 DOI: 10.1038/Sj.Onc.1204602 |
0.366 |
|
| 2001 |
Maxwell PH, Pugh CW, Ratcliffe PJ. Insights into the role of the von Hippel-Lindau gene product. A key player in hypoxic regulation. Experimental Nephrology. 9: 235-40. PMID 11423722 DOI: 10.1159/000052617 |
0.386 |
|
| 2001 |
Maxwell PH, Pugh CW, Ratcliffe PJ. Activation of the HIF pathway in cancer. Current Opinion in Genetics & Development. 11: 293-9. PMID 11377966 DOI: 10.1016/S0959-437X(00)00193-3 |
0.37 |
|
| 2001 |
Clifford SC, Cockman ME, Smallwood AC, Mole DR, Woodward ER, Maxwell PH, Ratcliffe PJ, Maher ER. Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease. Human Molecular Genetics. 10: 1029-38. PMID 11331613 DOI: 10.1093/Hmg/10.10.1029 |
0.334 |
|
| 2001 |
McKeveney PJ, Hodges V, Mullan RN, Maxwell P, Simpson D, Thompson A, Winter PC, Lappin T, Maxwell AP. Characterization and localization of expression of an erythropoietin-induced gene, ERIC-1/TACC3, identified in erythroid precursor cells. British Journal of Haematology. 112: 1016-1024. PMID 11298601 DOI: 10.1046/J.1365-2141.2001.02644.X |
0.308 |
|
| 2001 |
Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, von Kriegsheim A, Hebestreit HF, Mukherji M, Schofield CJ, Maxwell PH, Pugh CW, Ratcliffe PJ. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science (New York, N.Y.). 292: 468-72. PMID 11292861 DOI: 10.1126/Science.1059796 |
0.345 |
|
| 2001 |
Ratcliffe PJ, Pugh CW, Maxwell PH. Targeting tumors through the HIF system. Nature Medicine. 6: 1315-6. PMID 11100107 DOI: 10.1038/82113 |
0.333 |
|
| 2000 |
Wykoff CC, Pugh CW, Maxwell PH, Harris AL, Ratcliffe PJ. Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling. Oncogene. 19: 6297-305. PMID 11175344 DOI: 10.1038/Sj.Onc.1204012 |
0.369 |
|
| 2000 |
Talks KL, Turley H, Gatter KC, Maxwell PH, Pugh CW, Ratcliffe PJ, Harris AL. The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. The American Journal of Pathology. 157: 411-21. PMID 10934146 DOI: 10.1016/S0002-9440(10)64554-3 |
0.341 |
|
| 2000 |
Ren X, Dorrington KL, Maxwell PH, Robbins PA. Effects of desferrioxamine on serum erythropoietin and ventilatory sensitivity to hypoxia in humans. Journal of Applied Physiology (Bethesda, Md. : 1985). 89: 680-6. PMID 10926654 DOI: 10.1152/Jappl.2000.89.2.680 |
0.311 |
|
| 2000 |
Cockman ME, Masson N, Mole DR, Jaakkola P, Chang GW, Clifford SC, Maher ER, Pugh CW, Ratcliffe PJ, Maxwell PH. Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein. The Journal of Biological Chemistry. 275: 25733-41. PMID 10823831 DOI: 10.1074/Jbc.M002740200 |
0.357 |
|
| 2000 |
Griffiths L, Binley K, Iqball S, Kan O, Maxwell P, Ratcliffe P, Lewis C, Harris A, Kingsman S, Naylor S. The macrophage - a novel system to deliver gene therapy to pathological hypoxia. Gene Therapy. 7: 255-262. PMID 10694803 DOI: 10.1038/Sj.Gt.3301058 |
0.322 |
|
| 1999 |
Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER, Ratcliffe PJ. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature. 399: 271-5. PMID 10353251 DOI: 10.1038/20459 |
0.371 |
|
| 1998 |
Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, Neeman M, Bono F, Abramovitch R, Maxwell P, Koch CJ, Ratcliffe P, Moons L, Jain RK, Collen D, et al. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature. 394: 485-90. PMID 9697772 DOI: 10.1038/28867 |
0.353 |
|
| 1998 |
Maxwell P, Ratcliffe P. Regulation of expression of the erythropoietin gene. Current Opinion in Hematology. 5: 166-70. PMID 9664154 DOI: 10.1097/00062752-199805000-00003 |
0.341 |
|
| 1998 |
Wood SM, Wiesener MS, Yeates KM, Okada N, Pugh CW, Maxwell PH, Ratcliffe PJ. Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression. The Journal of Biological Chemistry. 273: 8360-8. PMID 9525945 DOI: 10.1074/Jbc.273.14.8360 |
0.382 |
|
| 1998 |
Wiesener M, Turley H, Allen W, Willam C, Eckardt K, Talks K, Wood S, Gatter K, Harris A, Pugh C, Ratcliffe P, Maxwell P. Induction of Endothelial PAS Domain Protein-1 by Hypoxia: Characterization and Comparison With Hypoxia-Inducible Factor-1α Blood. 92: 2260-2268. DOI: 10.1182/Blood.V92.7.2260.2260_2260_2268 |
0.357 |
|
| 1998 |
Carmeliet P, Dor Y, Herbert J, Fukumura D, Brusselmans K, Dewerchin M, Neeman M, Bono F, Abramovitch R, Maxwell P, Koch CJ, Ratcliffe P, Moons L, Jain RK, Collen D, et al. Erratum: Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis Nature. 395: 525-525. DOI: 10.1038/26791 |
0.331 |
|
| 1997 |
Maxwell PH, Ferguson DJ, Nicholls LG, Johnson MH, Ratcliffe PJ. The interstitial response to renal injury: fibroblast-like cells show phenotypic changes and have reduced potential for erythropoietin gene expression. Kidney International. 52: 715-24. PMID 9291192 DOI: 10.1038/Ki.1997.387 |
0.314 |
|
| 1997 |
Maxwell PH, Dachs GU, Gleadle JM, Nicholls LG, Harris AL, Stratford IJ, Hankinson O, Pugh CW, Ratcliffe PJ. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proceedings of the National Academy of Sciences of the United States of America. 94: 8104-9. PMID 9223322 DOI: 10.1073/Pnas.94.15.8104 |
0.352 |
|
| 1997 |
Ratcliffe PJ, Ebert BL, Firth JD, Gleadle JM, Maxwell PH, Nagao M, O'Rourke JF, Pugh CW, Wood SM. Oxygen regulated gene expression: erythropoietin as a model system. Kidney International. 51: 514-26. PMID 9027732 DOI: 10.1038/Ki.1997.72 |
0.309 |
|
| 1994 |
Maxwell PH, Osmond MK, Pugh CW, Heryet A, Nicholls LG, Tan CC, Doe BG, Ferguson DJ, Johnson MH, Ratcliffe PJ. Identification of the renal erythropoietin-producing cells using transgenic mice. Kidney International. 44: 1149-62. PMID 8264149 DOI: 10.1038/Ki.1993.362 |
0.32 |
|
| 1994 |
Tay A, Maxwell P, Li Z, Goldberg H, Skorecki K. Cytosolic phospholipase A2 gene expression in rat mesangial cells is regulated post-transcriptionally. Biochemical Journal. 304: 417-422. PMID 7998975 DOI: 10.1042/Bj3040417 |
0.305 |
|
| 1993 |
Maxwell PH, Pugh CW, Ratcliffe PJ. Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism. Proceedings of the National Academy of Sciences of the United States of America. 90: 2423-7. PMID 8460154 DOI: 10.1073/Pnas.90.6.2423 |
0.364 |
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