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Andrew L. Lee - Publications

Affiliations: 
Chemical Biology and Medicinal Chemistry University of North Carolina at Chapel Hill Eshelman School of Pharmacy 
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56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Wang J, Jain A, McDonald LR, Gambogi C, Lee AL, Dokholyan NV. Mapping allosteric communications within individual proteins. Nature Communications. 11: 3862. PMID 32737291 DOI: 10.1038/S41467-020-17618-2  0.371
2020 Abramyan TM, Tropsha A, Lee AL, Sapienza PJ. Drugging Protein-Protein Interfaces of a Supramolecular Assembly as a Means to Overcome Resistance to Active Site Thymidylate Synthase Inhibitors Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.2836  0.304
2019 Ranasinghe C, Pagano PL, Sapienza PJ, Lee AL, Kohen A, Cheatum CM. Isotopic Labeling of Formate Dehydrogenase Perturbs the Protein Dynamics. The Journal of Physical Chemistry. B. PMID 31696711 DOI: 10.1021/Acs.Jpcb.9B08426  0.419
2019 Bonin JP, Sapienza PJ, Wilkerson E, Goldfarb D, Wang L, Herring L, Chen X, Major MB, Lee AL. Positive Cooperativity in Substrate Binding by Human Thymidylate Synthase. Biophysical Journal. PMID 31500803 DOI: 10.1016/J.Bpj.2019.08.015  0.324
2019 Sapienza PJ, Popov K, Mowrey DD, Falk BT, Dokholyan NV, Lee AL. Inter-Active Site Communication Mediated by the Dimer Interface Beta-Sheet in the Half-the-Sites Enzyme, Thymidylate Synthase. Biochemistry. PMID 31283187 DOI: 10.1021/Acs.Biochem.9B00486  0.397
2018 Lee AL, Sapienza PJ. Thermodynamic and NMR Assessment of Ligand Cooperativity and Intersubunit Communication in Symmetric Dimers: Application to Thymidylate Synthase. Frontiers in Molecular Biosciences. 5: 47. PMID 29888227 DOI: 10.3389/Fmolb.2018.00047  0.426
2017 Ranasinghe C, Guo Q, Sapienza PJ, Lee AL, Quinn DM, Cheatum CM, Kohen A. Protein Mass Effects on Formate Dehydrogenase. Journal of the American Chemical Society. PMID 29083897 DOI: 10.1021/Jacs.7B08359  0.374
2016 Sapienza PJ, Lee AL. Widespread perturbation of function, structure, and dynamics by a conservative single atom substitution in thymidylate synthase. Biochemistry. PMID 27649373 DOI: 10.1021/Acs.Biochem.6B00838  0.38
2016 Falk BT, Sapienza PJ, Lee AL. Chemical shift imprint of intersubunit communication in a symmetric homodimer. Proceedings of the National Academy of Sciences of the United States of America. PMID 27466406 DOI: 10.1073/Pnas.1604748113  0.395
2016 Sapienza PJ, Li L, Williams T, Lee AL, Carter CW. An Ancestral Tryptophanyl-tRNA Synthetase Precursor Achieves High Catalytic Rate Enhancement Without Ordered Ground-State Tertiary Structures. Acs Chemical Biology. PMID 27008438 DOI: 10.1021/Acschembio.5B01011  0.36
2016 Francis K, Sapienza PJ, Lee AL, Kohen A. The Effect of the Protein Mass Modulation on Human Dihydrofolate Reductase. Biochemistry. PMID 26813442 DOI: 10.1021/Acs.Biochem.5B00945  0.416
2015 Lee AL. Contrasting roles of dynamics in protein allostery: NMR and structural studies of CheY and the third PDZ domain from PSD-95. Biophysical Reviews. 7: 217-226. PMID 28510172 DOI: 10.1007/S12551-015-0169-3  0.426
2015 Sapienza PJ, Falk BT, Lee AL. Bacterial Thymidylate Synthase Binds Two Molecules of Substrate and Cofactor without Cooperativity. Journal of the American Chemical Society. PMID 26517288 DOI: 10.1021/Jacs.5B10128  0.332
2015 Lee AL. Contrasting roles of dynamics in protein allostery: NMR and structural studies of CheY and the third PDZ domain from PSD-95 Biophysical Reviews. 7: 217-226. DOI: 10.1007/s12551-015-0169-3  0.319
2014 Petit CM, Lee AL. Monitoring side-chain dynamics of proteins using (2)H relaxation. Methods in Molecular Biology (Clifton, N.J.). 1084: 3-27. PMID 24061913 DOI: 10.1007/978-1-62703-658-0_1  0.376
2014 Sapienza PJ, Lee AL. Backbone and ILV methyl resonance assignments of E. coli thymidylate synthase bound to cofactor and a nucleotide analogue. Biomolecular Nmr Assignments. 8: 195-9. PMID 23653343 DOI: 10.1007/S12104-013-9482-6  0.348
2013 McDonald LR, Whitley MJ, Boyer JA, Lee AL. Colocalization of fast and slow timescale dynamics in the allosteric signaling protein CheY. Journal of Molecular Biology. 425: 2372-81. PMID 23648838 DOI: 10.1016/J.Jmb.2013.04.029  0.719
2013 Wang Z, Sapienza PJ, Abeysinghe T, Luzum C, Lee AL, Finer-Moore JS, Stroud RM, Kohen A. Mg2+ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site. Journal of the American Chemical Society. 135: 7583-92. PMID 23611499 DOI: 10.1021/Ja400761X  0.347
2013 Zhang J, Lewis SM, Kuhlman B, Lee AL. Supertertiary structure of the MAGUK core from PSD-95. Structure (London, England : 1993). 21: 402-13. PMID 23395180 DOI: 10.1016/J.Str.2012.12.014  0.343
2012 McDonald LR, Boyer JA, Lee AL. Segmental motions, not a two-state concerted switch, underlie allostery in CheY. Structure (London, England : 1993). 20: 1363-73. PMID 22727815 DOI: 10.1016/J.Str.2012.05.008  0.702
2012 Mauldin RV, Sapienza PJ, Petit CM, Lee AL. Structure and dynamics of the G121V dihydrofolate reductase mutant: lessons from a transition-state inhibitor complex. Plos One. 7: e33252. PMID 22428003 DOI: 10.1371/Journal.Pone.0033252  0.447
2012 Carroll MJ, Mauldin RV, Gromova AV, Singleton SF, Collins EJ, Lee AL. Evidence for dynamics in proteins as a mechanism for ligand dissociation. Nature Chemical Biology. 8: 246-52. PMID 22246400 DOI: 10.1038/Nchembio.769  0.362
2011 Zhang J, Petit CM, King DS, Lee AL. Phosphorylation of a PDZ domain extension modulates binding affinity and interdomain interactions in postsynaptic density-95 (PSD-95) protein, a membrane-associated guanylate kinase (MAGUK). The Journal of Biological Chemistry. 286: 41776-85. PMID 21965656 DOI: 10.1074/Jbc.M111.272583  0.33
2011 Carroll MJ, Gromova AV, Miller KR, Tang H, Wang XS, Tripathy A, Singleton SF, Collins EJ, Lee AL. Direct detection of structurally resolved dynamics in a multiconformation receptor-ligand complex. Journal of the American Chemical Society. 133: 6422-8. PMID 21469679 DOI: 10.1021/Ja2005253  0.426
2011 Whitley MJ, Lee AL. Exploring the role of structure and dynamics in the function of chymotrypsin inhibitor 2 Proteins: Structure, Function and Bioinformatics. 79: 916-924. PMID 21287622 DOI: 10.1002/Prot.22930  0.459
2011 Sapienza PJ, Mauldin RV, Lee AL. Multi-timescale dynamics study of FKBP12 along the rapamycin-mTOR binding coordinate. Journal of Molecular Biology. 405: 378-94. PMID 21073880 DOI: 10.1016/J.Jmb.2010.10.037  0.423
2010 Sapienza PJ, Lee AL. Using NMR to study fast dynamics in proteins: methods and applications. Current Opinion in Pharmacology. 10: 723-30. PMID 20933469 DOI: 10.1016/J.Coph.2010.09.006  0.461
2010 Zhang J, Sapienza PJ, Ke H, Chang A, Hengel SR, Wang H, Phillips GN, Lee AL. Crystallographic and nuclear magnetic resonance evaluation of the impact of peptide binding to the second PDZ domain of protein tyrosine phosphatase 1E. Biochemistry. 49: 9280-91. PMID 20839809 DOI: 10.1021/Bi101131F  0.409
2010 Boyer JA, Clay CJ, Luce KS, Edgell MH, Lee AL. Detection of native-state nonadditivity in double mutant cycles via hydrogen exchange. Journal of the American Chemical Society. 132: 8010-9. PMID 20481530 DOI: 10.1021/Ja1003922  0.713
2010 Mauldin RV, Lee AL. Nuclear magnetic resonance study of the role of M42 in the solution dynamics of escherichia coli dihydrofolate reductase Biochemistry. 49: 1606-1615. PMID 20073522 DOI: 10.1021/Bi901798G  0.461
2010 Sapienza P, Lee A. Ligand Induced Changes in FKBP12 ps-ns Dynamics: The Rapamycin-Bound Enzyme Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr16931  0.349
2010 Sapienza P, Lee A. Ligand Induced Changes in FKBP12 ps-ns Dynamics: The Free Enzyme Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr16925  0.342
2009 Petit CM, Zhang J, Sapienza PJ, Fuentes EJ, Lee AL. Hidden dynamic allostery in a PDZ domain. Proceedings of the National Academy of Sciences of the United States of America. 106: 18249-54. PMID 19828436 DOI: 10.1073/Pnas.0904492106  0.389
2009 Law AB, Fuentes EJ, Lee AL. Conservation of side-chain dynamics within a protein family. Journal of the American Chemical Society. 131: 6322-3. PMID 19374353 DOI: 10.1021/Ja809915A  0.449
2009 Whitley MJ, Lee AL. Frameworks for understanding long-range intra-protein communication Current Protein and Peptide Science. 10: 116-127. PMID 19355979 DOI: 10.2174/138920309787847563  0.397
2009 Mauldin RV, Carroll MJ, Lee AL. Dynamic dysfunction in dihydrofolate reductase results from antifolate drug binding: modulation of dynamics within a structural state. Structure (London, England : 1993). 17: 386-94. PMID 19278653 DOI: 10.1016/J.Str.2009.01.005  0.435
2008 Schneider GF, Shaw BF, Lee A, Carillho E, Whitesides GM. Pathway for unfolding of ubiquitin in sodium dodecyl sulfate, studied by capillary electrophoresis. Journal of the American Chemical Society. 130: 17384-93. PMID 19035631 DOI: 10.1021/Ja804736T  0.313
2008 Whitley MJ, Zhang J, Lee AL. Hydrophobic core mutations in CI2 globally perturb fast side-chain dynamics similarly without regard to position Biochemistry. 47: 8566-8576. PMID 18656953 DOI: 10.1021/Bi8007966  0.429
2008 Boyer JA, Lee AL. Monitoring aromatic picosecond to nanosecond dynamics in proteins via 13C relaxation: Expanding perturbation mapping of the rigidifying core mutation, V54A, in eglin c Biochemistry. 47: 4876-4886. PMID 18393447 DOI: 10.1021/Bi702330T  0.724
2008 Fuentes EJ, Gilmore SA, Mauldin RV, Lee AL. Corrigendum to "Evaluation of Energetic and Dynamic Coupling Networks in a PDZ Domain Protein" [J. Mol. Biol. 364 (2006) 337-351] (DOI:10.1016/j.jmb.2006.08.076) Journal of Molecular Biology. 375: 1489-1490. DOI: 10.1016/J.Jmb.2007.11.058  0.37
2007 DeRose EF, Clarkson MW, Gilmore SA, Galban CJ, Tripathy A, Havener JM, Mueller GA, Ramsden DA, London RE, Lee AL. Solution structure of polymerase mu's BRCT Domain reveals an element essential for its role in nonhomologous end joining. Biochemistry. 46: 12100-10. PMID 17915942 DOI: 10.1021/Bi7007728  0.339
2006 Fuentes EJ, Gilmore SA, Mauldin RV, Lee AL. Evaluation of energetic and dynamic coupling networks in a PDZ domain protein. Journal of Molecular Biology. 364: 337-51. PMID 17011581 DOI: 10.1016/J.Jmb.2006.08.076  0.451
2006 Bryant JE, Lecomte JT, Lee AL, Young GB, Pielak GJ. Cytosol has a small effect on protein backbone dynamics. Biochemistry. 45: 10085-91. PMID 16906766 DOI: 10.1021/Bi060547B  0.363
2006 Clarkson MW, Gilmore SA, Edgell MH, Lee AL. Dynamic coupling and allosteric behavior in a nonallosteric protein. Biochemistry. 45: 7693-9. PMID 16784220 DOI: 10.1021/Bi060652L  0.486
2005 Igumenova TI, Lee AL, Wand AJ. Backbone and side chain dynamics of mutant calmodulin-peptide complexes. Biochemistry. 44: 12627-39. PMID 16171378 DOI: 10.1021/Bi050832F  0.301
2005 Hu H, Hermans J, Lee AL. Relating side-chain mobility in proteins to rotameric transitions: insights from molecular dynamics simulations and NMR. Journal of Biomolecular Nmr. 32: 151-62. PMID 16034666 DOI: 10.1007/S10858-005-5366-0  0.44
2005 Bryant JE, Lecomte JT, Lee AL, Young GB, Pielak GJ. Protein dynamics in living cells. Biochemistry. 44: 9275-9. PMID 15981993 DOI: 10.1021/Bi050786J  0.45
2004 Clarkson MW, Lee AL. Long-range dynamic effects of point mutations propagate through side chains in the serine protease inhibitor eglin c Biochemistry. 43: 12448-12458. PMID 15449934 DOI: 10.1021/Bi0494424  0.445
2004 Ohnishi S, Lee AL, Edgell MH, Shortle D. Direct demonstration of structural similarity between native and denatured eglin C. Biochemistry. 43: 4064-70. PMID 15065848 DOI: 10.1021/Bi049879B  0.376
2004 Fuentes EJ, Der CJ, Lee AL. Ligand-dependent dynamics and intramolecular signaling in a PDZ domain. Journal of Molecular Biology. 335: 1105-15. PMID 14698303 DOI: 10.1016/J.Jmb.2003.11.010  0.465
2003 Hu H, Clarkson MW, Hermans J, Lee AL. Increased rigidity of eglin c at acidic pH: evidence from NMR spin relaxation and MD simulations. Biochemistry. 42: 13856-68. PMID 14636053 DOI: 10.1021/Bi035015Z  0.368
2003 Prabhu NV, Lee AL, Wand AJ, Sharp KA. Dynamics and entropy of a calmodulin-peptide complex studied by NMR and molecular dynamics. Biochemistry. 42: 562-70. PMID 12525185 DOI: 10.1021/Bi026544Q  0.377
2001 Walsh ST, Lee AL, DeGrado WF, Wand AJ. Dynamics of a de novo designed three-helix bundle protein studied by 15N, 13C, and 2H NMR relaxation methods. Biochemistry. 40: 9560-9. PMID 11583155 DOI: 10.1021/Bi0105274  0.429
2001 Lee AL, Wand AJ. Microscopic origins of entropy, heat capacity and the glass transition in proteins Nature. 411: 501-504. PMID 11373686 DOI: 10.1038/35078119  0.314
2000 Lee AL, Kinnear SA, Wand AJ. Redistribution and loss of side chain entropy upon formation of a calmodulin-peptide complex Nature Structural Biology. 7: 72-77. PMID 10625431 DOI: 10.1038/71280  0.32
1999 Volkman BF, Wilkens SJ, Lee AL, Xia B, Westler WM, Beger R, Markley JL. Redox-dependent magnetic alignment of Clostridium pasteurianum rubredoxin: Measurement of magnetic susceptibility anisotropy and prediction of pseudocontact shift contributions Journal of the American Chemical Society. 121: 4677-4683. DOI: 10.1021/Ja990079B  0.448
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