Ivan Ahel - Publications

Affiliations: 
2009-2013 Cancer Research UK Manchester Institute 
 2013- Oxford University UK 
Area:
DNA damage response
Website:
https://www.path.ox.ac.uk/content/ivan-ahel

101 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Mosler T, Baymaz HI, Gräf JF, Mikicic I, Blattner G, Bartlett E, Ostermaier M, Piccinno R, Yang J, Voigt A, Gatti M, Pellegrino S, Altmeyer M, Luck K, Ahel I, et al. PARP1 proximity proteomics reveals interaction partners at stressed replication forks. Nucleic Acids Research. PMID 36350633 DOI: 10.1093/nar/gkac948  0.396
2022 Zhu K, Suskiewicz MJ, Hloušek-Kasun A, Meudal H, Mikoč A, Aucagne V, Ahel D, Ahel I. DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on protein substrates. Science Advances. 8: eadd4253. PMID 36197986 DOI: 10.1126/sciadv.add4253  0.783
2022 Hloušek-Kasun A, Mikolčević P, Rack JGM, Tromans-Coia C, Schuller M, Jankevicius G, Matković M, Bertoša B, Ahel I, Mikoč A. macrodomain hydrolase SCO6735 cleaves thymidine-linked ADP-ribosylation of DNA. Computational and Structural Biotechnology Journal. 20: 4337-4350. PMID 36051881 DOI: 10.1016/j.csbj.2022.08.002  0.849
2022 Gahbauer S, Correy GJ, Schuller M, Ferla MP, Doruk YU, Rachman M, Wu T, Diolaiti M, Wang S, Neitz RJ, Fearon D, Radchenko D, Moroz Y, Irwin JJ, Renslo AR, ... ... Ahel I, et al. Structure-based inhibitor optimization for the Nsp3 Macrodomain of SARS-CoV-2. Biorxiv : the Preprint Server For Biology. PMID 35794891 DOI: 10.1101/2022.06.27.497816  0.729
2022 Schuller M, Ahel I. Beyond protein modification: the rise of non-canonical ADP-ribosylation. The Biochemical Journal. 479: 463-477. PMID 35175282 DOI: 10.1042/BCJ20210280  0.771
2021 Schützenhofer K, Rack JGM, Ahel I. The Making and Breaking of Serine-ADP-Ribosylation in the DNA Damage Response. Frontiers in Cell and Developmental Biology. 9: 745922. PMID 34869334 DOI: 10.3389/fcell.2021.745922  0.463
2021 Hendriks IA, Buch-Larsen SC, Prokhorova E, Elsborg JD, Rebak AKLFS, Zhu K, Ahel D, Lukas C, Ahel I, Nielsen ML. The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome. Nature Communications. 12: 5893. PMID 34625544 DOI: 10.1038/s41467-021-26172-4  0.822
2021 Kong L, Feng B, Yan Y, Zhang C, Kim JH, Xu L, Rack JGM, Wang Y, Jang JC, Ahel I, Shan L, He P. Noncanonical mono(ADP-ribosyl)ation of zinc finger SZF proteins counteracts ubiquitination for protein homeostasis in plant immunity. Molecular Cell. PMID 34592134 DOI: 10.1016/j.molcel.2021.09.006  0.336
2021 Tromans-Coia C, Sanchi A, Moeller GK, Timinszky G, Lopes M, Ahel I. TARG1 protects against toxic DNA ADP-ribosylation. Nucleic Acids Research. PMID 34508355 DOI: 10.1093/nar/gkab771  0.42
2021 Beijer D, Agnew T, Rack JGM, Prokhorova E, Deconinck T, Ceulemans B, Peric S, Milic Rasic V, De Jonghe P, Ahel I, Baets J. Biallelic mutations in complex neuropathy affect ADP ribosylation and DNA damage response. Life Science Alliance. 4. PMID 34479984 DOI: 10.26508/lsa.202101057  0.306
2021 Schuller M, Butler RE, Ariza A, Tromans-Coia C, Jankevicius G, Claridge TDW, Kendall SL, Goh S, Stewart GR, Ahel I. Molecular basis for DarT ADP-ribosylation of a DNA base. Nature. PMID 34408320 DOI: 10.1038/s41586-021-03825-4  0.851
2021 Palazzo L, Suskiewicz MJ, Ahel I. Serine ADP-ribosylation in DNA-damage response regulation. Current Opinion in Genetics & Development. 71: 106-113. PMID 34340015 DOI: 10.1016/j.gde.2021.07.005  0.834
2021 Lüscher B, Ahel I, Altmeyer M, Ashworth A, Bai P, Chang P, Cohen M, Corda D, Dantzer F, Daugherty MD, Dawson TM, Dawson VL, Deindl S, Fehr AR, Feijs KLH, et al. ADP-ribosyltransferases, an update on function and nomenclature. The Febs Journal. PMID 34323016 DOI: 10.1111/febs.16142  0.722
2021 Rack JGM, Liu Q, Zorzini V, Voorneveld J, Ariza A, Honarmand Ebrahimi K, Reber JM, Krassnig SC, Ahel D, van der Marel GA, Mangerich A, McCullagh JSO, Filippov DV, Ahel I. Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal. Nature Communications. 12: 4581. PMID 34321462 DOI: 10.1038/s41467-021-24723-3  0.815
2021 Prokhorova E, Zobel F, Smith R, Zentout S, Gibbs-Seymour I, Schützenhofer K, Peters A, Groslambert J, Zorzini V, Agnew T, Brognard J, Nielsen ML, Ahel D, Huet S, Suskiewicz MJ, ... Ahel I, et al. Serine-linked PARP1 auto-modification controls PARP inhibitor response. Nature Communications. 12: 4055. PMID 34210965 DOI: 10.1038/s41467-021-24361-9  0.807
2021 Groslambert J, Prokhorova E, Ahel I. ADP-ribosylation of DNA and RNA. Dna Repair. 105: 103144. PMID 34116477 DOI: 10.1016/j.dnarep.2021.103144  0.414
2021 Bajusz D, Wade WS, Satała G, Bojarski AJ, Ilaš J, Ebner J, Grebien F, Papp H, Jakab F, Douangamath A, Fearon D, von Delft F, Schuller M, Ahel I, Wakefield A, et al. Exploring protein hotspots by optimized fragment pharmacophores. Nature Communications. 12: 3201. PMID 34045440 DOI: 10.1038/s41467-021-23443-y  0.713
2021 Prokhorova E, Agnew T, Wondisford AR, Tellier M, Kaminski N, Beijer D, Holder J, Groslambert J, Suskiewicz MJ, Zhu K, Reber JM, Krassnig SC, Palazzo L, Murphy S, Nielsen ML, ... ... Ahel I, et al. Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease. Molecular Cell. PMID 34019811 DOI: 10.1016/j.molcel.2021.04.028  0.804
2021 Schuller M, Correy GJ, Gahbauer S, Fearon D, Wu T, Díaz RE, Young ID, Carvalho Martins L, Smith DH, Schulze-Gahmen U, Owens TW, Deshpande I, Merz GE, Thwin AC, Biel JT, ... ... Ahel I, et al. Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking. Science Advances. 7. PMID 33853786 DOI: 10.1126/sciadv.abf8711  0.735
2021 Voorneveld J, Rack J, van Gijlswijk L, Meeuwenoord N, Liu Q, Overkleeft H, van der Marel G, Ahel I, Filippov D. Molecular Tools for the Study of ADP-ribosylation: A Unified and Versatile Method to Synthesise Native Mono-ADP-ribosylated Peptides. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 33769608 DOI: 10.1002/chem.202100337  0.368
2020 Genois MM, Gagné JP, Yasuhara T, Jackson J, Saxena S, Langelier MF, Ahel I, Bedford MT, Pascal JM, Vindigni A, Poirier GG, Zou L. CARM1 regulates replication fork speed and stress response by stimulating PARP1. Molecular Cell. PMID 33412112 DOI: 10.1016/j.molcel.2020.12.010  0.313
2020 Hewitt G, Borel V, Segura-Bayona S, Takaki T, Ruis P, Bellelli R, Lehmann LC, Sommerova L, Vancevska A, Tomas-Loba A, Zhu K, Cooper C, Fugger K, Patel H, Goldstone R, ... ... Ahel I, et al. Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD. Molecular Cell. PMID 33333017 DOI: 10.1016/j.molcel.2020.12.006  0.821
2020 Schuller M, Correy GJ, Gahbauer S, Fearon D, Wu T, Díaz RE, Young ID, Martins LC, Smith DH, Schulze-Gahmen U, Owens TW, Deshpande I, Merz GE, Thwin AC, Biel JT, ... ... Ahel I, et al. Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational Docking. Biorxiv : the Preprint Server For Biology. PMID 33269349 DOI: 10.1101/2020.11.24.393405  0.733
2020 Rack JGM, Zorzini V, Zhu Z, Schuller M, Ahel D, Ahel I. Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential. Open Biology. 10: 200237. PMID 33202171 DOI: 10.1098/rsob.200237  0.777
2020 Bilokapic S, Suskiewicz MJ, Ahel I, Halic M. Bridging of DNA breaks activates PARP2-HPF1 to modify chromatin. Nature. 585: 609-613. PMID 32939087 DOI: 10.1038/S41586-020-2725-7  0.849
2020 Suskiewicz MJ, Palazzo L, Hughes R, Ahel I. Progress and outlook in studying the substrate specificities of PARPs and related enzymes. The Febs Journal. PMID 32785980 DOI: 10.1111/Febs.15518  0.828
2020 Hanzlikova H, Prokhorova E, Krejcikova K, Cihlarova Z, Kalasova I, Kubovciak J, Sachova J, Hailstone R, Brazina J, Ghosh S, Cirak S, Gleeson JG, Ahel I, Caldecott KW. Pathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair. Nature Communications. 11: 3391. PMID 32636369 DOI: 10.1038/S41467-020-17069-9  0.518
2020 Rack JGM, Palazzo L, Ahel I. (ADP-ribosyl)hydrolases: structure, function, and biology. Genes & Development. 34: 263-284. PMID 32029451 DOI: 10.1101/Gad.334631.119  0.401
2020 Suskiewicz MJ, Zobel F, Ogden TEH, Fontana P, Ariza A, Yang JC, Zhu K, Bracken L, Hawthorne WJ, Ahel D, Neuhaus D, Ahel I. HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation. Nature. PMID 32028527 DOI: 10.1038/S41586-020-2013-6  0.833
2020 Lawarée E, Jankevicius G, Cooper C, Ahel I, Uphoff S, Tang CM. DNA ADP-Ribosylation Stalls Replication and Is Reversed by RecF-Mediated Homologous Recombination and Nucleotide Excision Repair. Cell Reports. 30: 1373-1384.e4. PMID 32023456 DOI: 10.1016/J.Celrep.2020.01.014  0.803
2019 Munnur D, Bartlett E, Mikolčević P, Kirby IT, Matthias Rack JG, Mikoč A, Cohen MS, Ahel I. Reversible ADP-ribosylation of RNA. Nucleic Acids Research. 47: 5658-5669. PMID 31216043 DOI: 10.1093/Nar/Gkz305  0.478
2019 Palazzo L, Mikolčević P, Mikoč A, Ahel I. ADP-ribosylation signalling and human disease. Open Biology. 9: 190041. PMID 30991935 DOI: 10.1098/Rsob.190041  0.419
2019 Munnur D, Somers J, Skalka G, Weston R, Jukes-Jones R, Bhogadia M, Dominguez C, Cain K, Ahel I, Malewicz M. NR4A Nuclear Receptors Target Poly-ADP-Ribosylated DNA-PKcs Protein to Promote DNA Repair. Cell Reports. 26: 2028-2036.e6. PMID 30784586 DOI: 10.1016/J.Celrep.2019.01.083  0.504
2018 Rack JGM, Ariza A, Drown BS, Henfrey C, Bartlett E, Shirai T, Hergenrother PJ, Ahel I. (ADP-ribosyl)hydrolases: Structural Basis for Differential Substrate Recognition and Inhibition. Cell Chemical Biology. 25: 1533-1546.e12. PMID 30472116 DOI: 10.2210/Pdb6Hh4/Pdb  0.459
2018 Palazzo L, Ahel I. PARPs in genome stability and signal transduction: implications for cancer therapy. Biochemical Society Transactions. 46: 1681-1695. PMID 30420415 DOI: 10.1042/Bst20180418  0.503
2018 Drown BS, Shirai T, Rack JGM, Ahel I, Hergenrother PJ. Monitoring Poly(ADP-ribosyl)glycohydrolase Activity with a Continuous Fluorescent Substrate. Cell Chemical Biology. PMID 30318463 DOI: 10.1016/J.Chembiol.2018.09.008  0.432
2018 Bartlett E, Bonfiglio JJ, Prokhorova E, Colby T, Zobel F, Ahel I, Matic I. Interplay of Histone Marks with Serine ADP-Ribosylation. Cell Reports. 24: 3488-3502.e5. PMID 30257210 DOI: 10.1016/J.Celrep.2018.08.092  0.447
2018 Posavec Marjanovic M, Jankevicius G, Ahel I. Hydrolysis of ADP-Ribosylation by Macrodomains. Methods in Molecular Biology (Clifton, N.J.). 1813: 215-223. PMID 30097870 DOI: 10.1007/978-1-4939-8588-3_14  0.816
2018 Kwasna D, Abdul Rehman SA, Natarajan J, Matthews S, Madden R, De Cesare V, Weidlich S, Virdee S, Ahel I, Gibbs-Seymour I, Kulathu Y. Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability. Molecular Cell. PMID 29576527 DOI: 10.1016/J.Molcel.2018.02.023  0.832
2018 Palazzo L, Leidecker O, Prokhorova E, Dauben H, Matic I, Ahel I. Serine is the major residue for ADP-ribosylation upon DNA damage. Elife. 7. PMID 29480802 DOI: 10.7554/Elife.34334  0.565
2018 Agnew T, Munnur D, Crawford K, Palazzo L, Mikoč A, Ahel I. MacroD1 Is a Promiscuous ADP-Ribosyl Hydrolase Localized to Mitochondria. Frontiers in Microbiology. 9: 20. PMID 29410655 DOI: 10.3389/Fmicb.2018.00020  0.495
2018 Palazzo L, Leidecker O, Prokhorova E, Dauben H, Matic I, Ahel I. Author response: Serine is the major residue for ADP-ribosylation upon DNA damage Elife. DOI: 10.7554/Elife.34334.011  0.453
2017 Fehr AR, Jankevicius G, Ahel I, Perlman S. Viral Macrodomains: Unique Mediators of Viral Replication and Pathogenesis. Trends in Microbiology. PMID 29268982 DOI: 10.1016/J.Tim.2017.11.011  0.789
2017 Crawford K, Bonfiglio JJ, Mikoč A, Matic I, Ahel I. Specificity of reversible ADP-ribosylation and regulation of cellular processes. Critical Reviews in Biochemistry and Molecular Biology. 1-19. PMID 29098880 DOI: 10.1080/10409238.2017.1394265  0.359
2017 Munnur D, Ahel I. Reversible mono-ADP-ribosylation of DNA breaks. The Febs Journal. 284: 4002-4016. PMID 29054115 DOI: 10.1111/Febs.14297  0.545
2017 Schuller M, Riedel K, Gibbs-Seymour I, Uth K, Sieg C, Gehring AP, Ahel I, Bracher F, Kessler BM, Elkins JM, Knapp S. Discovery of a selective allosteric inhibitor targeting macrodomain 2 of poly-adenosine-diphosphate-ribose polymerases 14. Acs Chemical Biology. PMID 28991428 DOI: 10.1021/Acschembio.7B00445  0.808
2017 Marjanović MP, Hurtado-Bagès S, Lassi M, Valero V, Malinverni R, Delage H, Navarro M, Corujo D, Guberovic I, Douet J, Gama-Perez P, Garcia-Roves PM, Ahel I, Ladurner AG, Yanes O, et al. MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD(+) consumption. Nature Structural & Molecular Biology. PMID 28991266 DOI: 10.1038/Nsmb.3481  0.652
2017 Palazzo L, James DI, Waddell ID, Ahel I. Studying Catabolism of Protein ADP-Ribosylation. Methods in Molecular Biology (Clifton, N.J.). 1608: 415-430. PMID 28695524 DOI: 10.1007/978-1-4939-6993-7_26  0.512
2017 Fontana P, Bonfiglio JJ, Palazzo L, Bartlett E, Matic I, Ahel I. Serine ADP-ribosylation reversal by the hydrolase ARH3. Elife. 6. PMID 28650317 DOI: 10.7554/Elife.28533  0.572
2017 Palazzo L, Mikoč A, Ahel I. ADP-ribosylation: new facets of an ancient modification. The Febs Journal. 284: 2932-2946. PMID 28383827 DOI: 10.1111/Febs.14078  0.486
2017 Bonfiglio JJ, Fontana P, Zhang Q, Colby T, Gibbs-Seymour I, Atanassov I, Bartlett E, Zaja R, Ahel I, Matic I. Serine ADP-Ribosylation Depends on HPF1. Molecular Cell. PMID 28190768 DOI: 10.1016/J.Molcel.2017.01.003  0.844
2016 Fehr AR, Channappanavar R, Jankevicius G, Fett C, Zhao J, Athmer J, Meyerholz DK, Ahel I, Perlman S. The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus Infection. Mbio. 7. PMID 27965448 DOI: 10.1128/Mbio.01721-16  0.752
2016 Jankevicius G, Ariza A, Ahel M, Ahel I. The Toxin-Antitoxin System DarTG Catalyzes Reversible ADP-Ribosylation of DNA. Molecular Cell. 64: 1109-1116. PMID 27939941 DOI: 10.1016/J.Molcel.2016.11.014  0.814
2016 Leidecker O, Bonfiglio JJ, Colby T, Zhang Q, Atanassov I, Zaja R, Palazzo L, Stockum A, Ahel I, Matic I. Serine is a new target residue for endogenous ADP-ribosylation on histones. Nature Chemical Biology. PMID 27723750 DOI: 10.1038/Nchembio.2180  0.498
2016 Posavec Marjanović M, Crawford K, Ahel I. PARP, transcription and chromatin modeling. Seminars in Cell & Developmental Biology. PMID 27677453 DOI: 10.1016/J.Semcdb.2016.09.014  0.398
2016 Lalić J, Posavec Marjanović M, Palazzo L, Perina D, Sabljić I, Žaja R, Colby T, Pleše B, Halasz M, Jankevicius G, Bucca G, Ahel M, Matić I, Ćetković H, Luić M, ... ... Ahel I, et al. Disruption of macrodomain protein SCO6735 increases antibiotic production in Streptomyces coelicolor. The Journal of Biological Chemistry. PMID 27634042 DOI: 10.1074/Jbc.M116.721894  0.799
2016 Gunn AR, Banos-Pinero B, Paschke P, Sanchez-Pulido L, Ariza A, Day J, Emrich M, Leys D, Ponting CP, Ahel I, Lakin ND. The role of ADP-ribosylation in regulating DNA interstrand crosslink repair. Journal of Cell Science. PMID 27587838 DOI: 10.1242/Jcs.193375  0.546
2016 Staples CJ, Barone G, Myers KN, Ganesh A, Gibbs-Seymour I, Patil AA, Beveridge RD, Daye C, Beniston R, Maslen S, Ahel I, Skehel JM, Collis SJ. MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response. Cell Reports. PMID 27568553 DOI: 10.1016/J.Celrep.2016.07.087  0.834
2016 Li C, Debing Y, Jankevicius G, Neyts J, Ahel I, Coutard B, Canard B. Viral Macro Domains Reverse Protein ADP-ribosylation. Journal of Virology. PMID 27440879 DOI: 10.1128/Jvi.00705-16  0.781
2016 Palazzo L, Daniels CM, Nettleship JE, Rahman N, McPherson RL, Ong SE, Kato K, Nureki O, Leung AK, Ahel I. ENPP1 processes protein ADP-ribosylation in vitro. The Febs Journal. PMID 27406238 DOI: 10.1111/Febs.13811  0.503
2016 Gibbs-Seymour I, Fontana P, Rack JGM, Ahel I. HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity. Molecular Cell. 62: 432-442. PMID 27067600 DOI: 10.1016/J.Molcel.2016.03.008  0.853
2016 Rack JG, Perina D, Ahel I. Macrodomains: Structure, Function, Evolution, and Catalytic Activities. Annual Review of Biochemistry. 85: 431-54. PMID 26844395 DOI: 10.1146/Annurev-Biochem-060815-014935  0.486
2016 Carter-O'Connell I, Jin H, Morgan RK, Zaja R, David LL, Ahel I, Cohen MS. Identifying Family-Member-Specific Targets of Mono-ARTDs by Using a Chemical Genetics Approach. Cell Reports. PMID 26774478 DOI: 10.1016/J.Celrep.2015.12.045  0.387
2015 Rack JG, Morra R, Barkauskaite E, Kraehenbuehl R, Ariza A, Qu Y, Ortmayer M, Leidecker O, Cameron DR, Matic I, Peleg AY, Leys D, Traven A, Ahel I. Identification of a Class of Protein ADP-Ribosylating Sirtuins in Microbial Pathogens. Molecular Cell. 59: 309-20. PMID 26166706 DOI: 10.1016/J.Molcel.2015.06.013  0.414
2015 Barkauskaite E, Jankevicius G, Ahel I. Structures and Mechanisms of Enzymes Employed in the Synthesis and Degradation of PARP-Dependent Protein ADP-Ribosylation. Molecular Cell. 58: 935-46. PMID 26091342 DOI: 10.1016/J.Molcel.2015.05.007  0.82
2015 Palazzo L, Thomas B, Jemth AS, Colby T, Leidecker O, Feijs KL, Zaja R, Loseva O, Puigvert JC, Matic I, Helleday T, Ahel I. Processing of protein ADP-ribosylation by Nudix hydrolases. The Biochemical Journal. 468: 293-301. PMID 25789582 DOI: 10.1042/Bj20141554  0.502
2015 Lambrecht MJ, Brichacek M, Barkauskaite E, Ariza A, Ahel I, Hergenrother PJ. Synthesis of dimeric ADP-ribose and its structure with human poly(ADP-ribose) glycohydrolase. Journal of the American Chemical Society. 137: 3558-64. PMID 25706250 DOI: 10.1021/Ja512528P  0.486
2014 Vyas S, Matic I, Uchima L, Rood J, Zaja R, Hay RT, Ahel I, Chang P. Family-wide analysis of poly(ADP-ribose) polymerase activity. Nature Communications. 5: 4426. PMID 25043379 DOI: 10.1038/Ncomms5426  0.433
2014 Perina D, Mikoč A, Ahel J, Ćetković H, Žaja R, Ahel I. Distribution of protein poly(ADP-ribosyl)ation systems across all domains of life. Dna Repair. 23: 4-16. PMID 24865146 DOI: 10.1016/J.Dnarep.2014.05.003  0.467
2014 Tallis M, Morra R, Barkauskaite E, Ahel I. Poly(ADP-ribosyl)ation in regulation of chromatin structure and the DNA damage response Chromosoma. 123: 79-90. PMID 24162931 DOI: 10.1007/S00412-013-0442-9  0.542
2013 Barkauskaite E, Brassington A, Tan ES, Warwicker J, Dunstan MS, Banos B, Lafite P, Ahel M, Mitchison TJ, Ahel I, Leys D. Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activities. Nature Communications. 4: 2164. PMID 23917065 DOI: 10.1038/Ncomms3164  0.41
2013 Barkauskaite E, Jankevicius G, Ladurner AG, Ahel I, Timinszky G. The recognition and removal of cellular poly(ADP-ribose) signals. The Febs Journal. 280: 3491-507. PMID 23711178 DOI: 10.1111/Febs.12358  0.828
2013 Sharifi R, Morra R, Appel CD, Tallis M, Chioza B, Jankevicius G, Simpson MA, Matic I, Ozkan E, Golia B, Schellenberg MJ, Weston R, Williams JG, Rossi MN, Galehdari H, ... ... Ahel I, et al. Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease. The Embo Journal. 32: 1225-37. PMID 23481255 DOI: 10.1038/Emboj.2013.51  0.808
2012 Zaja R, Mikoč A, Barkauskaite E, Ahel I. Molecular Insights into Poly(ADP-ribose) Recognition and Processing. Biomolecules. 3: 1-17. PMID 24970154 DOI: 10.3390/biom3010001  0.428
2012 Dunstan MS, Barkauskaite E, Lafite P, Knezevic CE, Brassington A, Ahel M, Hergenrother PJ, Leys D, Ahel I. Structure and mechanism of a canonical poly(ADP-ribose) glycohydrolase. Nature Communications. 3: 878. PMID 22673905 DOI: 10.1038/Ncomms1889  0.511
2011 Tumbale P, Appel CD, Kraehenbuehl R, Robertson PD, Williams JS, Krahn J, Ahel I, Williams RS. Structure of an aprataxin-DNA complex with insights into AOA1 neurodegenerative disease. Nature Structural & Molecular Biology. 18: 1189-95. PMID 21984210 DOI: 10.1038/nsmb.2146  0.386
2011 Slade D, Dunstan MS, Barkauskaite E, Weston R, Lafite P, Dixon N, Ahel M, Leys D, Ahel I. The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase. Nature. 477: 616-20. PMID 21892188 DOI: 10.1038/Nature10404  0.539
2011 Peterson FC, Chen D, Lytle BL, Rossi MN, Ahel I, Denu JM, Volkman BF. Orphan macrodomain protein (human C6orf130) is an O-acyl-ADP-ribose deacylase: solution structure and catalytic properties. The Journal of Biological Chemistry. 286: 35955-65. PMID 21849506 DOI: 10.1074/Jbc.M111.276238  0.432
2011 Chen D, Vollmar M, Rossi MN, Phillips C, Kraehenbuehl R, Slade D, Mehrotra PV, von Delft F, Crosthwaite SK, Gileadi O, Denu JM, Ahel I. Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases. The Journal of Biological Chemistry. 286: 13261-71. PMID 21257746 DOI: 10.1074/Jbc.M110.206771  0.431
2011 Mehrotra PV, Ahel D, Ryan DP, Weston R, Wiechens N, Kraehenbuehl R, Owen-Hughes T, Ahel I. DNA repair factor APLF is a histone chaperone. Molecular Cell. 41: 46-55. PMID 21211722 DOI: 10.1016/J.Molcel.2010.12.008  0.835
2010 Eustermann S, Brockmann C, Mehrotra PV, Yang JC, Loakes D, West SC, Ahel I, Neuhaus D. Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose). Nature Structural & Molecular Biology. 17: 241-3. PMID 20098424 DOI: 10.1038/Nsmb.1747  0.631
2009 Ahel D, Horejsí Z, Wiechens N, Polo SE, Garcia-Wilson E, Ahel I, Flynn H, Skehel M, West SC, Jackson SP, Owen-Hughes T, Boulton SJ. Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1. Science (New York, N.Y.). 325: 1240-3. PMID 19661379 DOI: 10.1126/Science.1177321  0.837
2008 Rass U, Ahel I, West SC. Molecular mechanism of DNA deadenylation by the neurological disease protein aprataxin. The Journal of Biological Chemistry. 283: 33994-4001. PMID 18836178 DOI: 10.1074/Jbc.M807124200  0.677
2008 Ahel I, Ahel D, Matsusaka T, Clark AJ, Pines J, Boulton SJ, West SC. Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins. Nature. 451: 81-5. PMID 18172500 DOI: 10.1038/Nature06420  0.84
2007 Rass U, Ahel I, West SC. Defective DNA repair and neurodegenerative disease. Cell. 130: 991-1004. PMID 17889645 DOI: 10.1016/J.Cell.2007.08.043  0.594
2007 Rass U, Ahel I, West SC. Actions of aprataxin in multiple DNA repair pathways. The Journal of Biological Chemistry. 282: 9469-74. PMID 17276982 DOI: 10.1074/Jbc.M611489200  0.662
2006 Ahel I, Rass U, El-Khamisy SF, Katyal S, Clements PM, McKinnon PJ, Caldecott KW, West SC. The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. Nature. 443: 713-6. PMID 16964241 DOI: 10.1038/Nature05164  0.654
2005 Ahel I, Mikoc A, Gamulin V. recA gene expression in a streptomycete is mediated by the unusual C-terminus of RecA protein. Fems Microbiology Letters. 248: 119-24. PMID 15953699 DOI: 10.1016/J.Femsle.2005.05.030  0.376
2004 Ambrogelly A, Kamtekar S, Sauerwald A, Ruan B, Tumbula-Hansen D, Kennedy D, Ahel I, Söll D. Cys-tRNACys formation and cysteine biosynthesis in methanogenic archaea: two faces of the same problem? Cellular and Molecular Life Sciences. 61: 2437-2445. PMID 15526152 DOI: 10.1007/S00018-004-4194-9  0.611
2004 Gamulin V, Cetkovic H, Ahel I. Identification of a promoter motif regulating the major DNA damage response mechanism of Mycobacterium tuberculosis. Fems Microbiology Letters. 238: 57-63. PMID 15336403 DOI: 10.1016/J.Femsle.2004.07.017  0.473
2004 Korencic D, Ahel I, Schelert J, Sacher M, Ruan B, Stathopoulos C, Blum P, Ibba M, Söll D. A freestanding proofreading domain is required for protein synthesis quality control in Archaea. Proceedings of the National Academy of Sciences of the United States of America. 101: 10260-5. PMID 15240874 DOI: 10.1073/Pnas.0403926101  0.642
2003 Ahel I, Korencic D, Ibba M, Söll D. Trans-editing of mischarged tRNAs. Proceedings of the National Academy of Sciences of the United States of America. 100: 15422-7. PMID 14663147 DOI: 10.1073/Pnas.2136934100  0.66
2003 Salazar JC, Ahel I, Orellana O, Tumbula-Hansen D, Krieger R, Daniels L, Söll D. Coevolution of an aminoacyl-tRNA synthetase with its tRNA substrates. Proceedings of the National Academy of Sciences of the United States of America. 100: 13863-8. PMID 14615592 DOI: 10.1073/Pnas.1936123100  0.637
2003 Waters E, Hohn MJ, Ahel I, Graham DE, Adams MD, Barnstead M, Beeson KY, Bibbs L, Bolanos R, Keller M, Kretz K, Lin X, Mathur E, Ni J, Podar M, et al. The genome of Nanoarchaeum equitans: insights into early archaeal evolution and derived parasitism. Proceedings of the National Academy of Sciences of the United States of America. 100: 12984-8. PMID 14566062 DOI: 10.1073/Pnas.1735403100  0.619
2002 Ambrogelly A, Ahel I, Polycarpo C, Bunjun-Srihari S, Krett B, Jacquin-Becker C, Ruan B, Köhrer C, Stathopoulos C, RajBhandary UL, Söll D. Methanocaldococcus jannaschii prolyl-tRNA synthetase charges tRNA(Pro) with cysteine. The Journal of Biological Chemistry. 277: 34749-54. PMID 12130658 DOI: 10.1074/Jbc.M206929200  0.545
2002 Ahel I, Stathopoulos C, Ambrogelly A, Sauerwald A, Toogood H, Hartsch T, Söll D. Cysteine activation is an inherent in vitro property of prolyl-tRNA synthetases. The Journal of Biological Chemistry. 277: 34743-8. PMID 12130657 DOI: 10.1074/Jbc.M206928200  0.638
2002 Feng L, Stathopoulos C, Ahel I, Mitra A, Tumbula-Hansen D, Hartsch T, Söll D. Aminoacyl-tRNA formation in the extreme thermophile Thermus thermophilus Extremophiles. 6: 167-174. PMID 12013438 DOI: 10.1007/S007920100245  0.64
2002 Ahel I, Vujaklija D, Mikoc A, Gamulin V. Transcriptional analysis of the recA gene in Streptomyces rimosus: identification of the new type of promoter. Fems Microbiology Letters. 209: 133-7. PMID 12007666 DOI: 10.1111/J.1574-6968.2002.Tb11121.X  0.367
2002 Jacquin-Becker C, Ahel I, Ambrogelly A, Ruan B, Söll D, Stathopoulos C. Cysteinyl-tRNA formation and prolyl-tRNA synthetase. Febs Letters. 514: 34-6. PMID 11904177 DOI: 10.1016/S0014-5793(02)02331-1  0.637
2001 Stathopoulos C, Ahel I, Ali K, Ambrogelly A, Becker H, Bunjun S, Feng L, Herring S, Jacquin-Becker C, Kobayashi H, Korencic D, Krett B, Mejlhede N, Min B, Nakano H, et al. Aminoacyl-tRNA synthesis: a postgenomic perspective. Cold Spring Harbor Symposia On Quantitative Biology. 66: 175-83. PMID 12762020 DOI: 10.1101/Sqb.2001.66.175  0.748
2001 Ruan B, Ahel I, Ambrogelly A, Becker HD, Bunjun S, Feng L, Tumbula-Hansen D, Ibba M, Korencic D, Kobayashi H, Jacquin-Becker C, Mejlhede N, Min B, Raczniak G, Rinehart J, et al. Genomics and the evolution of aminoacyl-tRNA synthesis. Acta Biochimica Polonica. 48: 313-21. PMID 11732603 DOI: 10.18388/Abp.2001_3917  0.78
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