John Leong - Publications

Affiliations: 
Molecular Genetics and Microbiology University of Massachusetts Medical School, Worcester, MA, United States 

68 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Xu S, Mo D, Rizvi FZ, Rosa JP, Ruiz J, Tan S, Tweten RK, Leong JM, Adams W. Pore-forming activity of pneumolysin disrupts the paracellular localization of the epithelial adherens junction protein E-cadherin. Infection and Immunity. e0021323. PMID 37607057 DOI: 10.1128/iai.00213-23  0.375
2022 Gelfat I, Aqeel Y, Tremblay JM, Jaskiewicz JJ, Shrestha A, Lee JN, Hu S, Qian X, Magoun L, Sheoran A, Bedenice D, Giem C, Manjula-Basavanna A, Pulsifer AR, Tu HX, ... ... Leong JM, et al. Single domain antibodies against enteric pathogen virulence factors are active as curli fiber fusions on probiotic E. coli Nissle 1917. Plos Pathogens. 18: e1010713. PMID 36107831 DOI: 10.1371/journal.ppat.1010713  0.321
2022 Tan X, Lin YP, Pereira MJ, Castellanos M, Hahn BL, Anderson P, Coburn J, Leong JM, Chaconas G. VlsE, the nexus for antigenic variation of the Lyme disease spirochete, also mediates early bacterial attachment to the host microvasculature under shear force. Plos Pathogens. 18: e1010511. PMID 35605029 DOI: 10.1371/journal.ppat.1010511  0.306
2018 Garber JJ, Mallick EM, Scanlon KM, Turner JR, Donnenberg MS, Leong JM, Snapper SB. Attaching-and-Effacing Pathogens Exploit Junction Regulatory Activities of N-WASP and SNX9 to Disrupt the Intestinal Barrier. Cellular and Molecular Gastroenterology and Hepatology. 5: 273-288. PMID 29675452 DOI: 10.1016/J.Jcmgh.2017.11.015  0.407
2017 Lithgow KV, Kao W, Hof R, Petrosova H, Lin Y, Boulanger MJ, Leong J, Burke JE, Moriarty TJ, Cameron CE. P1.29 Attachment of the syphilis spirochete, treponema pallidum, to the vascular endothelium Sexually Transmitted Infections. 93. DOI: 10.1136/Sextrans-2017-053264.137  0.354
2015 Yang X, Lin YP, Heselpoth RD, Buyuktanir O, Qin J, Kung F, Nelson DC, Leong JM, Pal U. Middle region of the Borrelia burgdorferi surface-located protein 1 (Lmp1) interacts with host chondroitin-6-sulfate and independently facilitates infection. Cellular Microbiology. PMID 26247174 DOI: 10.1111/Cmi.12487  0.314
2015 Lin YP, Bhowmick R, Coburn J, Leong JM. Host cell heparan sulfate glycosaminoglycans are ligands for OspF-related proteins of the Lyme disease spirochete. Cellular Microbiology. PMID 25864455 DOI: 10.1111/Cmi.12448  0.308
2014 Battle SE, Brady MJ, Vanaja SK, Leong JM, Hecht GA. Actin pedestal formation by enterohemorrhagic Escherichia coli enhances bacterial host cell attachment and concomitant type III translocation. Infection and Immunity. 82: 3713-22. PMID 24958711 DOI: 10.1128/Iai.01523-13  0.537
2014 Mallick EM, Garber JJ, Vanguri VK, Balasubramanian S, Blood T, Clark S, Vingadassalom D, Louissaint C, McCormick B, Snapper SB, Leong JM. The ability of an attaching and effacing pathogen to trigger localized actin assembly contributes to virulence by promoting mucosal attachment. Cellular Microbiology. 16: 1405-24. PMID 24780054 DOI: 10.1111/cmi.12302  0.392
2013 Lai Y, Rosenshine I, Leong JM, Frankel G. Intimate host attachment: enteropathogenic and enterohaemorrhagic Escherichia coli. Cellular Microbiology. 15: 1796-808. PMID 23927593 DOI: 10.1111/cmi.12179  0.458
2013 Garber J, Mallick E, Scanlon K, Donnenberg M, Leong J, Snapper S. O-029 The Attaching-and-effacing Pathogen Effector EspF Exploits Homeostatic Tight Junction Regulatory Activities of N-WASP and SNX9 to Induce Intestinal Barrier Dysfunction Inflammatory Bowel Diseases. 19: S16-S17. DOI: 10.1097/01.Mib.0000438580.80786.65  0.37
2012 Moriarty TJ, Shi M, Lin YP, Ebady R, Zhou H, Odisho T, Hardy PO, Salman-Dilgimen A, Wu J, Weening EH, Skare JT, Kubes P, Leong J, Chaconas G. Vascular binding of a pathogen under shear force through mechanistically distinct sequential interactions with host macromolecules. Molecular Microbiology. 86: 1116-31. PMID 23095033 DOI: 10.1111/Mmi.12045  0.405
2012 Garber JJ, Takeshima F, Antón IM, Oyoshi MK, Lyubimova A, Kapoor A, Shibata T, Chen F, Alt FW, Geha RS, Leong JM, Snapper SB. Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly. Infection and Immunity. 80: 4071-7. PMID 22966049 DOI: 10.1128/Iai.06148-11  0.489
2012 Aitio O, Hellman M, Skehan B, Kesti T, Leong JM, Saksela K, Permi P. Enterohaemorrhagic Escherichia coli exploits a tryptophan switch to hijack host f-actin assembly. Structure (London, England : 1993). 20: 1692-703. PMID 22921828 DOI: 10.1016/j.str.2012.07.015  0.524
2012 Campellone KG, Siripala AD, Leong JM, Welch MD. Membrane-deforming proteins play distinct roles in actin pedestal biogenesis by enterohemorrhagic Escherichia coli. The Journal of Biological Chemistry. 287: 20613-24. PMID 22544751 DOI: 10.1074/Jbc.M112.363473  0.796
2012 Mallick EM, Brady MJ, Luperchio SA, Vanguri VK, Magoun L, Liu H, Sheppard BJ, Mukherjee J, Donohue-Rolfe A, Tzipori S, Leong JM, Schauer DB. Allele- and tir-independent functions of intimin in diverse animal infection models. Frontiers in Microbiology. 3: 11. PMID 22347213 DOI: 10.3389/fmicb.2012.00011  0.336
2012 Garber J, Mallick E, Leong J, Snapper S. Enteropathogenic E. coli Induces Intestinal Barrier Dysfunction by Exploiting Novel N-WASP-Mediated Cytoskeletal Junction Regulatory Activities Inflammatory Bowel Diseases. 18: S99. DOI: 10.1097/00054725-201212001-00250  0.382
2012 Rathinam V, Kailasan Vanaja S, Waggoner L, Sokolovska A, Becker C, Stuart L, Leong J, Fitzgerald K. O008 Type I interferons license caspase-11-dependent NLRP3 inflammasome activation by Gram-negative bacteria Cytokine. 59: 500. DOI: 10.1016/J.Cyto.2012.06.035  0.305
2011 Brady MJ, Radhakrishnan P, Liu H, Magoun L, Murphy KC, Mukherjee J, Donohue-Rolfe A, Tzipori S, Leong JM. Enhanced Actin Pedestal Formation by Enterohemorrhagic Escherichia coli O157:H7 Adapted to the Mammalian Host. Frontiers in Microbiology. 2: 226. PMID 22102844 DOI: 10.3389/fmicb.2011.00226  0.438
2011 Lai Y, Riley K, Cai A, Leong JM, Herman IM. Calpain mediates epithelial cell microvillar effacement by enterohemorrhagic Escherichia coli. Frontiers in Microbiology. 2: 222. PMID 22073041 DOI: 10.3389/fmicb.2011.00222  0.394
2011 de Groot JC, Schlüter K, Carius Y, Quedenau C, Vingadassalom D, Faix J, Weiss SM, Reichelt J, Standfuss-Gabisch C, Lesser CF, Leong JM, Heinz DW, Büssow K, Stradal TE. Structural basis for complex formation between human IRSp53 and the translocated intimin receptor Tir of enterohemorrhagic E. coli. Structure (London, England : 1993). 19: 1294-306. PMID 21893288 DOI: 10.1016/j.str.2011.06.015  0.453
2011 Piscatelli H, Kotkar SA, McBee ME, Muthupalani S, Schauer DB, Mandrell RE, Leong JM, Zhou D. The EHEC type III effector NleL is an E3 ubiquitin ligase that modulates pedestal formation. Plos One. 6: e19331. PMID 21541301 DOI: 10.1371/Journal.Pone.0019331  0.33
2011 Tree JJ, Roe AJ, Flockhart A, McAteer SP, Xu X, Shaw D, Mahajan A, Beatson SA, Best A, Lotz S, Woodward MJ, La Ragione R, Murphy KC, Leong JM, Gally DL. Transcriptional regulators of the GAD acid stress island are carried by effector protein-encoding prophages and indirectly control type III secretion in enterohemorrhagic Escherichia coli O157:H7. Molecular Microbiology. 80: 1349-65. PMID 21492263 DOI: 10.1111/j.1365-2958.2011.07650.x  0.305
2011 Heath RJ, Leong JM, Visegrády B, Machesky LM, Xavier RJ. Bacterial and host determinants of MAL activation upon EPEC infection: the roles of Tir, ABRA, and FLRT3. Plos Pathogens. 7: e1001332. PMID 21490959 DOI: 10.1371/journal.ppat.1001332  0.478
2011 Garber JJ, Shi HN, Nguyen DD, Maillard MH, Mallick E, Leong JM, Snapper SB. Citrobacter rodentium Requires Intestinal Neural Wiskott-Aldrich Syndrome Protein (N-WASp) for Actin Pedestal Formation, Colonization and Epithelial Barrier Disruption In Vivo Gastroenterology. 140: S-646. DOI: 10.1016/S0016-5085(11)62677-2  0.321
2010 Aitio O, Hellman M, Kazlauskas A, Vingadassalom DF, Leong JM, Saksela K, Permi P. Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assembly. Proceedings of the National Academy of Sciences of the United States of America. 107: 21743-8. PMID 21098279 DOI: 10.1073/pnas.1010243107  0.433
2010 Vingadassalom D, Campellone KG, Brady MJ, Skehan B, Battle SE, Robbins D, Kapoor A, Hecht G, Snapper SB, Leong JM. Enterohemorrhagic E. coli requires N-WASP for efficient type III translocation but not for EspFU-mediated actin pedestal formation. Plos Pathogens. 6: e1001056. PMID 20808845 DOI: 10.1371/Journal.Ppat.1001056  0.774
2009 Huett A, Leong JM, Podolsky DK, Xavier RJ. The cytoskeletal scaffold Shank3 is recruited to pathogen-induced actin rearrangements. Experimental Cell Research. 315: 2001-11. PMID 19371741 DOI: 10.1016/j.yexcr.2009.04.003  0.454
2009 Vingadassalom D, Kazlauskas A, Skehan B, Cheng HC, Magoun L, Robbins D, Rosen MK, Saksela K, Leong JM. Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF(U) during pedestal formation. Proceedings of the National Academy of Sciences of the United States of America. 106: 6754-9. PMID 19366662 DOI: 10.1073/Pnas.0809131106  0.513
2008 Padrick SB, Cheng HC, Ismail AM, Panchal SC, Doolittle LK, Kim S, Skehan BM, Umetani J, Brautigam CA, Leong JM, Rosen MK. Hierarchical regulation of WASP/WAVE proteins. Molecular Cell. 32: 426-38. PMID 18995840 DOI: 10.1016/J.Molcel.2008.10.012  0.408
2008 Campellone KG, Cheng HC, Robbins D, Siripala AD, McGhie EJ, Hayward RD, Welch MD, Rosen MK, Koronakis V, Leong JM. Repetitive N-WASP-binding elements of the enterohemorrhagic Escherichia coli effector EspF(U) synergistically activate actin assembly. Plos Pathogens. 4: e1000191. PMID 18974829 DOI: 10.1371/Journal.Ppat.1000191  0.794
2008 Mousnier A, Whale AD, Schüller S, Leong JM, Phillips AD, Frankel G. Cortactin recruitment by enterohemorrhagic Escherichia coli O157:H7 during infection in vitro and ex vivo. Infection and Immunity. 76: 4669-76. PMID 18678675 DOI: 10.1128/IAI.00140-08  0.426
2008 Cheng HC, Skehan BM, Campellone KG, Leong JM, Rosen MK. Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspF(U). Nature. 454: 1009-13. PMID 18650809 DOI: 10.1038/Nature07160  0.742
2008 Ritchie JM, Brady MJ, Riley KN, Ho TD, Campellone KG, Herman IM, Donohue-Rolfe A, Tzipori S, Waldor MK, Leong JM. EspFU, a type III-translocated effector of actin assembly, fosters epithelial association and late-stage intestinal colonization by E. coli O157:H7. Cellular Microbiology. 10: 836-47. PMID 18067584 DOI: 10.1111/J.1462-5822.2007.01087.X  0.719
2008 Cheng H, Skehan B, Campellone K, Leong J, Rosen M. Solution Structure of the GTPase Binding Domain of WASP in Complex with EspFU, an EHEC Effector Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2K42/Pdb  0.661
2007 Savage PJ, Campellone KG, Leong JM. Interaction of enterohemorrhagic Escherichia coli (EHEC) with mammalian cells: cell adhesion, type III secretion, and actin pedestal formation. Current Protocols in Microbiology. Unit 5A.1. PMID 18770622 DOI: 10.1002/9780471729259.Mc05A01S05  0.741
2007 Brady MJ, Campellone KG, Ghildiyal M, Leong JM. Enterohaemorrhagic and enteropathogenic Escherichia coli Tir proteins trigger a common Nck-independent actin assembly pathway. Cellular Microbiology. 9: 2242-53. PMID 17521329 DOI: 10.1111/J.1462-5822.2007.00954.X  0.776
2007 Campellone KG, Roe AJ, Løbner-Olesen A, Murphy KC, Magoun L, Brady MJ, Donohue-Rolfe A, Tzipori S, Gally DL, Leong JM, Marinus MG. Increased adherence and actin pedestal formation by dam-deficient enterohaemorrhagic Escherichia coli O157:H7. Molecular Microbiology. 63: 1468-81. PMID 17302821 DOI: 10.1111/J.1365-2958.2007.05602.X  0.729
2006 Campellone KG, Brady MJ, Alamares JG, Rowe DC, Skehan BM, Tipper DJ, Leong JM. Enterohaemorrhagic Escherichia coli Tir requires a C-terminal 12-residue peptide to initiate EspF-mediated actin assembly and harbours N-terminal sequences that influence pedestal length. Cellular Microbiology. 8: 1488-503. PMID 16922867 DOI: 10.1111/J.1462-5822.2006.00728.X  0.766
2006 Hayward RD, Leong JM, Koronakis V, Campellone KG. Exploiting pathogenic Escherichia coli to model transmembrane receptor signalling. Nature Reviews. Microbiology. 4: 358-70. PMID 16582930 DOI: 10.1038/Nrmicro1391  0.729
2006 Fischer JR, LeBlanc KT, Leong JM. Fibronectin binding protein BBK32 of the Lyme disease spirochete promotes bacterial attachment to glycosaminoglycans. Infection and Immunity. 74: 435-41. PMID 16368999 DOI: 10.1128/IAI.74.1.435-441.2006  0.331
2005 Coburn J, Fischer JR, Leong JM. Solving a sticky problem: new genetic approaches to host cell adhesion by the Lyme disease spirochete. Molecular Microbiology. 57: 1182-95. PMID 16101994 DOI: 10.1111/J.1365-2958.2005.04759.X  0.303
2005 Campellone KG, Leong JM. Nck-independent actin assembly is mediated by two phosphorylated tyrosines within enteropathogenic Escherichia coli Tir. Molecular Microbiology. 56: 416-32. PMID 15813734 DOI: 10.1111/J.1365-2958.2005.04558.X  0.758
2004 Campellone KG, Robbins D, Leong JM. EspFU is a translocated EHEC effector that interacts with Tir and N-WASP and promotes Nck-independent actin assembly. Developmental Cell. 7: 217-28. PMID 15296718 DOI: 10.1016/J.Devcel.2004.07.004  0.787
2004 Campellone KG, Rankin S, Pawson T, Kirschner MW, Tipper DJ, Leong JM. Clustering of Nck by a 12-residue Tir phosphopeptide is sufficient to trigger localized actin assembly. The Journal of Cell Biology. 164: 407-16. PMID 14757753 DOI: 10.1083/Jcb.200306032  0.772
2004 Touzé T, Hayward RD, Eswaran J, Leong JM, Koronakis V. Self-association of EPEC intimin mediated by the beta-barrel-containing anchor domain: a role in clustering of the Tir receptor. Molecular Microbiology. 51: 73-87. PMID 14651612 DOI: 10.1046/j.1365-2958.2003.03830.x  0.345
2003 Fischer JR, Parveen N, Magoun L, Leong JM. Decorin-binding proteins A and B confer distinct mammalian cell type-specific attachment by Borrelia burgdorferi, the Lyme disease spirochete. Proceedings of the National Academy of Sciences of the United States of America. 100: 7307-12. PMID 12773620 DOI: 10.1073/pnas.1231043100  0.316
2003 Campellone KG, Leong JM. Tails of two Tirs: actin pedestal formation by enteropathogenic E. coli and enterohemorrhagic E. coli O157:H7. Current Opinion in Microbiology. 6: 82-90. PMID 12615225 DOI: 10.1016/S1369-5274(03)00005-5  0.768
2003 Parveen N, Caimano M, Radolf JD, Leong JM. Adaptation of the Lyme disease spirochaete to the mammalian host environment results in enhanced glycosaminoglycan and host cell binding. Molecular Microbiology. 47: 1433-44. PMID 12603746 DOI: 10.1046/j.1365-2958.2003.03388.x  0.323
2002 Liu H, Radhakrishnan P, Magoun L, Prabu M, Campellone KG, Savage P, He F, Schiffer CA, Leong JM. Point mutants of EHEC intimin that diminish Tir recognition and actin pedestal formation highlight a putative Tir binding pocket. Molecular Microbiology. 45: 1557-73. PMID 12354225 DOI: 10.1046/J.1365-2958.2002.03137.X  0.736
2002 Campellone KG, Giese A, Tipper DJ, Leong JM. A tyrosine-phosphorylated 12-amino-acid sequence of enteropathogenic Escherichia coli Tir binds the host adaptor protein Nck and is required for Nck localization to actin pedestals Molecular Microbiology. 43: 1227-1241. PMID 11918809 DOI: 10.1046/J.1365-2958.2002.02817.X  0.77
1999 Liu H, Magoun L, Luperchio S, Schauer DB, Leong JM. The Tir-binding region of enterohaemorrhagic Escherichia coli intimin is sufficient to trigger actin condensation after bacterial-induced host cell signalling. Molecular Microbiology. 34: 67-81. PMID 10540286 DOI: 10.1046/j.1365-2958.1999.01574.x  0.494
1999 Stockbauer KE, Magoun L, Liu M, Burns EH, Gubba S, Renish S, Pan X, Bodary SC, Baker E, Coburn J, Leong JM, Musser JM. A natural variant of the cysteine protease virulence factor of group A Streptococcus with an arginine-glycine-aspartic acid (RGD) motif preferentially binds human integrins alphavbeta3 and alphaIIbbeta3. Proceedings of the National Academy of Sciences of the United States of America. 96: 242-7. PMID 9874803 DOI: 10.1073/pnas.96.1.242  0.338
1999 Liu H, Magoun L, Leong JM. β1-Chain Integrins Are Not Essential for Intimin-Mediated Host Cell Attachment and EnteropathogenicEscherichia coli-Induced Actin Condensation Infection and Immunity. 67: 2045-2049. DOI: 10.1128/IAI.67.4.2045-2049.1999  0.33
1999 Liu H, Magoun L, Leong JM. β1-Chain Integrins Are Not Essential for Intimin-Mediated Host Cell Attachment and EnteropathogenicEscherichia coli-Induced Actin Condensation Infection and Immunity. 67: 2045-2049. DOI: 10.1128/.67.4.2045-2049.1999  0.33
1995 Venturi V, Wolfs K, Leong J, Weisbeek PJ. Amplification of the groESL operon in Pseudomonas putida increases siderophore gene promoter activity. Molecular & General Genetics : Mgg. 245: 126-32. PMID 7845355 DOI: 10.1007/Bf00279758  0.324
1995 Leong JM, Morrissey PE, Ortega-Barria E, Pereira MEA, Coburn J. Hemagglutination and proteoglycan binding by the Lyme disease spirochete, Borrelia burgdorferi. Infection and Immunity. 63: 874-883. PMID 7532628 DOI: 10.1128/Iai.63.3.874-883.1995  0.325
1994 Koster M, van Klompenburg W, Bitter W, Leong J, Weisbeek P. Role for the outer membrane ferric siderophore receptor PupB in signal transduction across the bacterial cell envelope. The Embo Journal. 13: 2805-2813. DOI: 10.1002/J.1460-2075.1994.Tb06574.X  0.434
1993 Venturi V, Ottevanger C, Leong J, Weisbeek PJ. Identification and characterization of a siderophore regulatory gene (pfrA) of Pseudomonas putida WCS358: homology to the alginate regulatory gene aigQ of Pseudomonas aeruginosa Molecular Microbiology. 10: 63-73. PMID 7968519 DOI: 10.1111/J.1365-2958.1993.Tb00904.X  0.329
1993 Koster M, Vossenberg J, Leong J, Weisbeek PJ. Identification and characterization of the pupB gene encoding an inducible ferric-pseudobactin receptor of Pseudomonas putida WCS358 Molecular Microbiology. 8: 591-601. DOI: 10.1111/J.1365-2958.1993.Tb01603.X  0.359
1992 Leong JM, Moitoso de Vargas L, Isberg RR. Binding of cultured mammalian cells to immobilized bacteria. Infection and Immunity. 60: 683-6. PMID 1730504 DOI: 10.1128/Iai.60.2.683-686.1992  0.369
1992 Rankin S, Isberg RR, Leong JM. The integrin-binding domain of invasin is sufficient to allow bacterial entry into mammalian cells. Infection and Immunity. 60: 3909-12. PMID 1500198 DOI: 10.1128/Iai.60.9.3909-3912.1992  0.381
1991 Leong JM, Fournier RS, Isberg RR. Mapping and topographic localization of epitopes of the Yersinia pseudotuberculosis invasin protein. Infection and Immunity. 59: 3424-33. PMID 1716609 DOI: 10.1128/Iai.59.10.3424-3433.1991  0.354
1990 Leong JM, Fournier RS, Isberg RR. Identification of the integrin binding domain of the Yersinia pseudotuberculosis invasin protein. The Embo Journal. 9: 1979-89. PMID 1693333 DOI: 10.1002/J.1460-2075.1990.Tb08326.X  0.343
1988 Isberg RR, Leong JM. Cultured mammalian cells attach to the invasin protein of Yersinia pseudotuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 85: 6682-6. PMID 3413117 DOI: 10.1073/Pnas.85.18.6682  0.365
1987 Dallas WS, Ray PH, Leong J, Benedict CD, Stamm LV, Bassford PJ. Identification and purification of a recombinant Treponema pallidum basic membrane protein antigen expressed in Escherichia coli. Infection and Immunity. 55: 1106-15. PMID 3552988 DOI: 10.1128/Iai.55.5.1106-1115.1987  0.368
1985 Leong J, Vinal AC, Dallas WS. Nucleotide sequence comparison between heat-labile toxin B-subunit cistrons from Escherichia coli of human and porcine origin. Infection and Immunity. 48: 73-77. PMID 3884513 DOI: 10.1128/Iai.48.1.73-77.1985  0.307
1984 Moores JC, Magazin M, Ditta GS, Leong J. Cloning of genes involved in the biosynthesis of pseudobactin, a high-affinity iron transport agent of a plant growth-promoting Pseudomonas strain. Journal of Bacteriology. 157: 53-8. PMID 6690426 DOI: 10.1128/Jb.157.1.53-58.1984  0.324
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