David D Moore - Publications

Affiliations: 
Baylor College of Medicine, Houston, TX 
Area:
molecular biology

114 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Li X, Yang L, Mao Z, Pan X, Zhao Y, Gu X, Eckel-Mahan K, Zuo Z, Tong Q, Hartig SM, Cheng X, Du G, Moore DD, Bellen HJ, Sesaki H, et al. Novel role of dynamin-related-protein 1 in dynamics of ER-lipid droplets in adipose tissue. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32294302 DOI: 10.1096/fj.201903100RR  0.52
2020 Himes RW, Mojarrad M, Eslahi A, Finegold MJ, Maroofian R, Moore DD. NR1H4-related Progressive Familial Intrahepatic Cholestasis 5: Further Evidence for Rapidly Progressive Liver Failure. Journal of Pediatric Gastroenterology and Nutrition. PMID 32097368 DOI: 10.1097/MPG.0000000000002670  0.56
2020 Panzitt K, Jungwirth E, Krones E, Lee JM, Pollheimer M, Thallinger GG, Kolb-Lenz D, Xiao R, Thorell A, Trauner M, Fickert P, Marschall HU, Moore DD, Wagner M. FXR-dependent Rubicon induction impairs autophagy in models of human cholestasis. Journal of Hepatology. PMID 32001325 DOI: 10.1016/j.jhep.2020.01.014  0.92
2020 Wooton-Kee CR, Robertson M, Zhou Y, Dong B, Sun Z, Kim KH, Liu H, Xu Y, Putluri N, Saha P, Coarfa C, Moore DD, Nuotio-Antar AM. Metabolic dysregulation in the Wilson's disease mouse model. Proceedings of the National Academy of Sciences of the United States of America. PMID 31924743 DOI: 10.1073/pnas.1914267117  1
2019 Dong B, Zhou Y, Wang W, Scott J, Kim KH, Sun Z, Guo Q, Lu Y, Gonzales NM, Wu H, Hartig S, York RB, Yang F, Moore DD. Vitamin D receptor activation in liver macrophages ameliorates hepatic inflammation, steatosis, and insulin resistance in mice. Hepatology (Baltimore, Md.). PMID 31506976 DOI: 10.1002/hep.30937  1
2019 Mays S, Flynn AR, Cornelison J, Okafor CD, Wang H, Wang G, Huang X, Donaldson H, Millings E, Polavarapu R, Moore D, Calvert J, Jui NT, Ortlund EA. Development of the first low nanomolar Liver Receptor Homolog-1 agonist through structure-guided design. Journal of Medicinal Chemistry. PMID 31419141 DOI: 10.1021/acs.jmedchem.9b00753  0.52
2019 Zhou Y, Dong B, Kim KH, Choi S, Sun Z, Wu N, Wu Y, Scott J, Moore DD. Vitamin D receptor activation in liver macrophages protects against hepatic endoplasmic reticulum stress in mice. Hepatology (Baltimore, Md.). PMID 31381163 DOI: 10.1002/hep.30887  1
2019 Choi S, Dong B, Lin CJ, Heo MJ, Kim KH, Sun Z, Wagner M, Suh JM, Wang MC, Moore DD. Methyl-sensing nuclear receptor Liver Receptor Homolog-1 regulates mitochondrial function in mouse hepatocytes. Hepatology (Baltimore, Md.). PMID 31355949 DOI: 10.1002/hep.30884  1
2019 Wang W, Shen T, Dong B, Creighton CJ, Meng Y, Zhou W, Shi Q, Zhou H, Zhang Y, Moore DD, Yang F. MAPK4 overexpression promotes tumor progression via noncanonical activation of AKT/mTOR signaling. The Journal of Clinical Investigation. PMID 30688659 DOI: 10.1172/JCI97712  0.6
2019 Kim KH, Choi JM, Li F, Dong B, Wooton-Kee CR, Arizpe A, Anakk S, Jung SY, Hartig SM, Moore DD. Constitutive Androstane Receptor Differentially Regulates Bile Acid Homeostasis in Mouse Models of Intrahepatic Cholestasis. Hepatology Communications. 3: 147-159. PMID 30620001 DOI: 10.1002/hep4.1274  1
2018 Pankowicz FP, Barzi M, Kim KH, Legras X, Martins CS, Wooton-Kee CR, Lagor WR, Marini JC, Elsea SH, Bissig-Choisat B, Moore DD, Bissig KD. Rapid Disruption of Genes Specifically in Livers of Mice Using Multiplex CRISPR/Cas9 Editing. Gastroenterology. PMID 30170115 DOI: 10.1053/j.gastro.2018.08.037  1
2018 Yim SY, Shim JJ, Shin JH, Jeong YS, Kang SH, Kim SB, Eun YG, Lee DJ, Conner EA, Factor VM, Moore DD, Johnson RL, Thorgeirsson SS, Lee JS. Integrated Genomic Comparison of Mouse Models Reveals Their Clinical Resemblance to Human Liver Cancer. Molecular Cancer Research : McR. PMID 30082483 DOI: 10.1158/1541-7786.MCR-18-0313  0.56
2018 Koh EH, Chernis N, Saha PK, Xiao L, Bader DA, Zhu B, Rajapakshe K, Hamilton MP, Liu X, Perera D, Chen X, York B, Trauner M, Coarfa C, Bajaj M, ... Moore DD, et al. miR-30a Remodels Subcutaneous Adipose Tissue Inflammation to Improve Insulin Sensitivity in Obesity. Diabetes. PMID 30002134 DOI: 10.2337/db17-1378  0.68
2017 Duerrschmid C, He Y, Wang C, Li C, Bournat JC, Romere C, Saha PK, Lee ME, Phillips KJ, Jain M, Jia P, Zhao Z, Farias M, Wu Q, Milewicz DM, ... ... Moore DD, et al. Asprosin is a centrally acting orexigenic hormone. Nature Medicine. PMID 29106398 DOI: 10.1038/nm.4432  0.68
2017 Wang W, Meng Y, Dong B, Dong J, Ittmann MM, Creighton CJ, Yang L, Zhang H, Shen T, Wang J, Rowley DR, Li Y, Chen F, Moore DD, Yang F. A Versatile Tumor Gene Deletion System Reveals a Crucial Role for FGFR1 in Breast Cancer Metastasis. Neoplasia (New York, N.Y.). 19: 421-428. PMID 28433771 DOI: 10.1016/j.neo.2017.03.003  0.76
2017 Kim KH, Choi S, Zhou Y, Kim EY, Lee JM, Saha PK, Anakk S, Moore DD. Hepatic FXR/SHP Axis Modulates Systemic Glucose and Fatty Acid Homeostasis in Aged Mice. Hepatology (Baltimore, Md.). PMID 28378930 DOI: 10.1002/hep.29199  1
2017 Preidis GA, Kim KH, Moore DD. Nutrient-sensing nuclear receptors PPARα and FXR control liver energy balance. The Journal of Clinical Investigation. PMID 28287408 DOI: 10.1172/JCI88893  1
2017 Kim KH, Moore DD. Regulation of Liver Energy Balance by the Nuclear Receptors Farnesoid X Receptor and Peroxisome Proliferator Activated Receptor α. Digestive Diseases (Basel, Switzerland). 35: 203-209. PMID 28249296 DOI: 10.1159/000450912  1
2016 Kettner NM, Voicu H, Finegold MJ, Coarfa C, Sreekumar A, Putluri N, Katchy CA, Lee C, Moore DD, Fu L. Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis. Cancer Cell. PMID 27889186 DOI: 10.1016/j.ccell.2016.10.007  0.64
2016 Desai M, Mathur B, Eblimit Z, Vasquez H, Taegtmeyer H, Karpen S, Penny DJ, Moore DD, Anakk S. Bile acid excess induces cardiomyopathy and metabolic dysfunctions in the heart. Hepatology (Baltimore, Md.). PMID 27774647 DOI: 10.1002/hep.28890  0.68
2016 Wu N, Ho Kim K, Zhou Y, Man Lee J, Kettner NM, Mamrosh JL, Choi S, Fu L, Moore DD. Small Heterodimer Partner (NR0B2) Coordinates Nutrient Signaling and the Circadian Clock in Mice. Molecular Endocrinology (Baltimore, Md.). me20151295. PMID 27427832 DOI: 10.1210/me.2015-1295  0.92
2016 Ho Kim K, Lee JM, Zhou Y, Harpavat S, Moore DD. Glucocorticoids Have Opposing Effects on Liver Fibrosis in Hepatic Stellate and Immune Cells. Molecular Endocrinology (Baltimore, Md.). me20161029. PMID 27355192 DOI: 10.1210/me.2016-1029  0.92
2016 Sisley SR, Arble DM, Chambers AP, Gutierrez-Aguilar R, He Y, Xu Y, Gardner D, Moore DD, Seeley RJ, Sandoval DA. "Hypothalamic Vitamin D Improves Glucose Homeostasis and Reduces Weight". Diabetes. PMID 27217488 DOI: 10.2337/db16-0309  0.92
2016 Romere C, Duerrschmid C, Bournat J, Constable P, Jain M, Xia F, Saha PK, Del Solar M, Zhu B, York B, Sarkar P, Rendon DA, Gaber MW, LeMaire SA, Coselli JS, ... ... Moore DD, et al. Asprosin, a Fasting-Induced Glucogenic Protein Hormone. Cell. PMID 27087445 DOI: 10.1016/j.cell.2016.02.063  0.92
2016 Gomez-Ospina N, Potter CJ, Xiao R, Manickam K, Kim MS, Kim KH, Shneider BL, Picarsic JL, Jacobson TA, Zhang J, He W, Liu P, Knisely AS, Finegold MJ, Muzny DM, ... ... Moore DD, et al. Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis. Nature Communications. 7: 10713. PMID 26888176 DOI: 10.1038/ncomms10713  0.92
2015 Ahn HY, Kim HH, Kim YA, Kim M, Ohn JH, Chung SS, Lee YK, Park DJ, Park KS, Moore DD, Park YJ. Thyroid Hormone Regulates the mRNA Expression of Small Heterodimer Partner through Liver Receptor Homolog-1. Endocrinology and Metabolism (Seoul, Korea). PMID 26485468  0.72
2015 Wagner M, Choi S, Panzitt K, Mamrosh JL, Man Lee J, Zaufel A, Xiao R, Wooton-Kee R, Ståhlman M, Newgard CB, Borén J, Moore DD. LRH-1 is a critical determinant of methyl-pool metabolism. Hepatology (Baltimore, Md.). PMID 26267291 DOI: 10.1002/hep.28124  0.92
2015 Wooton-Kee CR, Jain AK, Wagner M, Grusak MA, Finegold MJ, Lutsenko S, Moore DD. Elevated copper impairs hepatic nuclear receptor function in Wilson's disease. The Journal of Clinical Investigation. PMID 26241054 DOI: 10.1172/JCI78991  0.64
2015 Mamrosh JL, Lee JM, Wagner M, Stambrook PJ, Whitby RJ, Sifers RN, Wu SP, Tsai MJ, DeMayo FJ, Moore DD. Correction: Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution. Elife. 4: e10084. PMID 26205891 DOI: 10.7554/eLife.10084  0.68
2015 Yuk JM, Kim TS, Kim SY, Lee HM, Han J, Dufour CR, Kim JK, Jin HS, Yang CS, Park KS, Lee CH, Kim JM, Kweon GR, Choi HS, Vanacker JM, ... Moore DD, et al. Orphan Nuclear Receptor ERRα Controls Macrophage Metabolic Signaling and A20 Expression to Negatively Regulate TLR-Induced Inflammation. Immunity. 43: 80-91. PMID 26200012 DOI: 10.1016/j.immuni.2015.07.003  0.92
2015 Hartig SM, Bader DA, Abadie KV, Motamed M, Hamilton MP, Long W, York B, Mueller M, Wagner M, Trauner M, Chan L, Bajaj M, Moore DD, Mancini MA, McGuire SE. Ubc9 Impairs Activation of the Brown Fat Energy Metabolism Program in Human White Adipocytes. Molecular Endocrinology (Baltimore, Md.). 29: 1320-33. PMID 26192107 DOI: 10.1210/me.2015-1084  0.92
2015 Kettner NM, Mayo SA, Hua J, Lee C, Moore DD, Fu L. Circadian Dysfunction Induces Leptin Resistance in Mice. Cell Metabolism. PMID 26166747 DOI: 10.1016/j.cmet.2015.06.005  0.92
2015 Mamrosh JL, Moore DD. Using Google Reverse Image Search to Decipher Biological Images. Current Protocols in Molecular Biology / Edited by Frederick M. Ausubel ... [Et Al.]. 111: 19.13.1-4. PMID 26131848 DOI: 10.1002/0471142727.mb1913s111  0.64
2015 Fu X, Dong B, Tian Y, Lefebvre P, Meng Z, Wang X, Pattou F, Han W, Wang X, Lou F, Jove R, Staels B, Moore DD, Huang W. MicroRNA-26a regulates insulin sensitivity and metabolism of glucose and lipids. The Journal of Clinical Investigation. 125: 2497-509. PMID 25961460 DOI: 10.1172/JCI75438  0.92
2015 Tseng HT, Park YJ, Lee YK, Moore DD. The orphan nuclear receptor small heterodimer partner is required for thiazolidinedione effects in leptin-deficient mice. Journal of Biomedical Science. 22: 30. PMID 25951943 DOI: 10.1186/s12929-015-0133-3  0.92
2015 Dong B, Lee JS, Park YY, Yang F, Xu G, Huang W, Finegold MJ, Moore DD. Activating CAR and β-catenin induces uncontrolled liver growth and tumorigenesis. Nature Communications. 6: 5944. PMID 25661872 DOI: 10.1038/ncomms6944  0.56
2015 Folick A, Oakley HD, Yu Y, Armstrong EH, Kumari M, Sanor L, Moore DD, Ortlund EA, Zechner R, Wang MC. Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans. Science (New York, N.Y.). 347: 83-6. PMID 25554789 DOI: 10.1126/science.1258857  0.92
2015 Desai MS, Eblimit Z, Thevananther S, Kosters A, Moore DD, Penny DJ, Karpen SJ. Cardiomyopathy reverses with recovery of liver injury, cholestasis and cholanemia in mouse model of biliary fibrosis. Liver International : Official Journal of the International Association For the Study of the Liver. 35: 1464-77. PMID 24330504 DOI: 10.1111/liv.12438  0.92
2014 Lee JM, Wagner M, Xiao R, Kim KH, Feng D, Lazar MA, Moore DD. Nutrient-sensing nuclear receptors coordinate autophagy. Nature. 516: 112-5. PMID 25383539 DOI: 10.1038/nature13961  0.92
2014 Mamrosh JL, Lee JM, Wagner M, Stambrook PJ, Whitby RJ, Sifers RN, Wu SP, Tsai MJ, Demayo FJ, Moore DD. Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution. Elife. 3: e01694. PMID 24737860 DOI: 10.7554/eLife.01694  0.92
2014 Chow EC, Magomedova L, Quach HP, Patel R, Durk MR, Fan J, Maeng HJ, Irondi K, Anakk S, Moore DD, Cummins CL, Pang KS. Vitamin D receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol. Gastroenterology. 146: 1048-59. PMID 24365583 DOI: 10.1053/j.gastro.2013.12.027  0.92
2014 Shah P, Guo T, Moore DD, Ghose R. Role of constitutive androstane receptor in Toll-like receptor-mediated regulation of gene expression of hepatic drug-metabolizing enzymes and transporters. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 172-81. PMID 24194512 DOI: 10.1124/dmd.113.053850  0.92
2014 Jung D, York JP, Wang L, Yang C, Zhang A, Francis HL, Webb P, McKeehan WL, Alpini G, Lesage GD, Moore DD, Xia X. FXR-induced secretion of FGF15/19 inhibits CYP27 expression in cholangiocytes through p38 kinase pathway. PflüGers Archiv : European Journal of Physiology. 466: 1011-9. PMID 24068255 DOI: 10.1007/s00424-013-1364-3  0.92
2014 Kim SC, Kim CK, Axe D, Cook A, Lee M, Li T, Smallwood N, Chiang JY, Hardwick JP, Moore DD, Lee YK. All-trans-retinoic acid ameliorates hepatic steatosis in mice by a novel transcriptional cascade. Hepatology (Baltimore, Md.). 59: 1750-60. PMID 24038081 DOI: 10.1002/hep.26699  0.92
2014 Kerr TA, Matsumoto Y, Matsumoto H, Xie Y, Hirschberger LL, Stipanuk MH, Anakk S, Moore DD, Watanabe M, Kennedy S, Davidson NO. Cysteine sulfinic acid decarboxylase regulation: A role for farnesoid X receptor and small heterodimer partner in murine hepatic taurine metabolism. Hepatology Research : the Official Journal of the Japan Society of Hepatology. 44: E218-28. PMID 24033844 DOI: 10.1111/hepr.12230  0.92
2013 Anakk S, Bhosale M, Schmidt VA, Johnson RL, Finegold MJ, Moore DD. Bile acids activate YAP to promote liver carcinogenesis. Cell Reports. 5: 1060-9. PMID 24268772 DOI: 10.1016/j.celrep.2013.10.030  0.92
2013 Lee J, Moulik M, Fang Z, Saha P, Zou F, Xu Y, Nelson DL, Ma K, Moore DD, Yechoor VK. Bmal1 and β-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced β-cell failure in mice. Molecular and Cellular Biology. 33: 2327-38. PMID 23547261 DOI: 10.1128/MCB.01421-12  0.92
2012 Xia X, Jung D, Webb P, Zhang A, Zhang B, Li L, Ayers SD, Gabbi C, Ueno Y, Gustafsson JÅ, Alpini G, Moore DD, Lesage GD. Liver X receptor β and peroxisome proliferator-activated receptor δ regulate cholesterol transport in murine cholangiocytes. Hepatology (Baltimore, Md.). 56: 2288-96. PMID 22729460 DOI: 10.1002/hep.25919  0.32
2012 Park YJ, Lee EK, Lee YK, Park do J, Jang HC, Moore DD. Opposing regulation of cytochrome P450 expression by CAR and PXR in hypothyroid mice. Toxicology and Applied Pharmacology. 263: 131-7. PMID 22503787 DOI: 10.1016/j.taap.2012.03.017  0.72
2012 Chen WD, Fu X, Dong B, Wang YD, Shiah S, Moore DD, Huang W. Neonatal activation of the nuclear receptor CAR results in epigenetic memory and permanent change of drug metabolism in mouse liver. Hepatology (Baltimore, Md.). 56: 1499-509. PMID 22488010 DOI: 10.1002/hep.25766  0.56
2012 Xiao R, Sun D, Ayers S, Xi Y, Li W, Baxter JD, Moore DD. Research resource: The estrogen receptor α cistrome defined by damIP Molecular Endocrinology. 26: 349-357. PMID 22207717 DOI: 10.1210/me.2011-1080  0.92
2011 Lee J, Kim MS, Li R, Liu VY, Fu L, Moore DD, Ma K, Yechoor VK. Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in β-cells. Islets. 3: 381-8. PMID 22045262 DOI: 10.4161/isl.3.6.18157  0.64
2011 Park YJ, Kim SC, Kim J, Anakk S, Lee JM, Tseng HT, Yechoor V, Park J, Choi JS, Jang HC, Lee KU, Novak CM, Moore DD, Lee YK. Dissociation of diabetes and obesity in mice lacking orphan nuclear receptor small heterodimer partner. Journal of Lipid Research. 52: 2234-44. PMID 21949050 DOI: 10.1194/jlr.M016048  0.92
2011 Sberna AL, Assem M, Xiao R, Ayers S, Gautier T, Guiu B, Deckert V, Chevriaux A, Grober J, Le Guern N, Pais de Barros JP, Moore DD, Lagrost L, Masson D. Constitutive androstane receptor activation decreases plasma apolipoprotein B-containing lipoproteins and atherosclerosis in low-density lipoprotein receptor-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 2232-9. PMID 21778422 DOI: 10.1161/ATVBAHA.110.222497  0.92
2011 Smetanina MA, Pakharukova MY, Kurinna SM, Dong B, Hernandez JP, Moore DD, Merkulova TI. Ortho-aminoazotoluene activates mouse constitutive androstane receptor (mCAR) and increases expression of mCAR target genes. Toxicology and Applied Pharmacology. 255: 76-85. PMID 21672546 DOI: 10.1016/j.taap.2011.05.019  0.56
2011 Lee JM, Lee YK, Mamrosh JL, Busby SA, Griffin PR, Pathak MC, Ortlund EA, Moore DD. A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects. Nature. 474: 506-10. PMID 21614002 DOI: 10.1038/nature10111  0.92
2011 Wagner M, Moore DD. Endoplasmic reticulum stress and glucose homeostasis. Current Opinion in Clinical Nutrition and Metabolic Care. 14: 367-73. PMID 21543975 DOI: 10.1097/MCO.0b013e32834778d4  0.64
2011 Dwivedi SK, Singh N, Kumari R, Mishra JS, Tripathi S, Banerjee P, Shah P, Kukshal V, Tyagi AM, Gaikwad AN, Chaturvedi RK, Mishra DP, Trivedi AK, Sanyal S, Chattopadhyay N, ... ... Moore DD, et al. Bile acid receptor agonist GW4064 regulates PPARγ coactivator-1α expression through estrogen receptor-related receptor α. Molecular Endocrinology (Baltimore, Md.). 25: 922-32. PMID 21493670 DOI: 10.1210/me.2010-0512  0.92
2011 Xiao R, Moore DD. DamIP: using mutant DNA adenine methyltransferase to study DNA-protein interactions in vivo. Current Protocols in Molecular Biology / Edited by Frederick M. Ausubel ... [Et Al.]. Unit21.21. PMID 21472695 DOI: 10.1002/0471142727.mb2121s94  0.92
2011 Chopra AR, Kommagani R, Saha P, Louet JF, Salazar C, Song J, Jeong J, Finegold M, Viollet B, DeMayo F, Chan L, Moore DD, O'Malley BW. Cellular energy depletion resets whole-body energy by promoting coactivator-mediated dietary fuel absorption. Cell Metabolism. 13: 35-43. PMID 21195347 DOI: 10.1016/j.cmet.2010.12.001  0.56
2011 Anakk S, Watanabe M, Ochsner SA, McKenna NJ, Finegold MJ, Moore DD. Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis. The Journal of Clinical Investigation. 121: 86-95. PMID 21123943 DOI: 10.1172/JCI42846  0.92
2010 Gupte AA, Liu JZ, Ren Y, Minze LJ, Wiles JR, Collins AR, Lyon CJ, Pratico D, Finegold MJ, Wong ST, Webb P, Baxter JD, Moore DD, Hsueh WA. Rosiglitazone attenuates age- and diet-associated nonalcoholic steatohepatitis in male low-density lipoprotein receptor knockout mice. Hepatology (Baltimore, Md.). 52: 2001-11. PMID 20938947 DOI: 10.1002/hep.23941  0.92
2010 Lee S, Donehower LA, Herron AJ, Moore DD, Fu L. Disrupting circadian homeostasis of sympathetic signaling promotes tumor development in mice. Plos One. 5: e10995. PMID 20539819 DOI: 10.1371/journal.pone.0010995  0.64
2010 Xiao R, Roman-Sanchez R, Moore DD. DamIP: a novel method to identify DNA binding sites in vivo Nuclear Receptor Signaling. 8. PMID 20419059  0.92
2009 Dong B, Saha PK, Huang W, Chen W, Abu-Elheiga LA, Wakil SJ, Stevens RD, Ilkayeva O, Newgard CB, Chan L, Moore DD. Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease. Proceedings of the National Academy of Sciences of the United States of America. 106: 18831-6. PMID 19850873 DOI: 10.1073/pnas.0909731106  0.92
2009 Ma K, Xiao R, Tseng HT, Shan L, Fu L, Moore DD. Circadian dysregulation disrupts bile acid homeostasis. Plos One. 4: e6843. PMID 19718444 DOI: 10.1371/journal.pone.0006843  0.92
2009 Margolis RN, Moore DD, Willson TM, Guy RK. Chemical approaches to nuclear receptors in metabolism. Science Signaling. 2: mr5. PMID 19654413 DOI: 10.1126/scisignal.282mr5  0.92
2009 Del Bas JM, Ricketts ML, Vaqué M, Sala E, Quesada H, Ardevol A, Salvadó MJ, Blay M, Arola L, Moore DD, Pujadas G, Fernandez-Larrea J, Bladé C. Dietary procyanidins enhance transcriptional activity of bile acid-activated FXR in vitro and reduce triglyceridemia in vivo in a FXR-dependent manner. Molecular Nutrition & Food Research. 53: 805-14. PMID 19496086 DOI: 10.1002/mnfr.200800364  0.92
2009 Dong B, Qatanani M, Moore DD. Constitutive androstane receptor mediates the induction of drug metabolism in mouse models of type 1 diabetes. Hepatology (Baltimore, Md.). 50: 622-9. PMID 19489075 DOI: 10.1002/hep.23025  0.56
2009 Li T, Ma H, Park YJ, Lee YK, Strom S, Moore DD, Chiang JY. Forkhead box transcription factor O1 inhibits cholesterol 7alpha-hydroxylase in human hepatocytes and in high fat diet-fed mice. Biochimica Et Biophysica Acta. 1791: 991-6. PMID 19463968 DOI: 10.1016/j.bbalip.2009.05.004  0.72
2009 McKenna NJ, Cooney AJ, DeMayo FJ, Downes M, Glass CK, Lanz RB, Lazar MA, Mangelsdorf DJ, Moore DD, Qin J, Steffen DL, Tsai MJ, Tsai SY, Yu R, Margolis RN, et al. Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas. Molecular Endocrinology (Baltimore, Md.). 23: 740-6. PMID 19423650 DOI: 10.1210/me.2009-0135  0.92
2009 Li Y, Ross-Viola JS, Shay NF, Moore DD, Ricketts ML. Human CYP3A4 and murine Cyp3A11 are regulated by equol and genistein via the pregnane X receptor in a species-specific manner. The Journal of Nutrition. 139: 898-904. PMID 19297428 DOI: 10.3945/jn.108.103572  0.92
2009 Zhang L, Huang X, Meng Z, Dong B, Shiah S, Moore DD, Huang W. Significance and mechanism of CYP7a1 gene regulation during the acute phase of liver regeneration. Molecular Endocrinology (Baltimore, Md.). 23: 137-45. PMID 19056864 DOI: 10.1210/me.2008-0198  0.56
2008 Wang YD, Chen WD, Moore DD, Huang W. FXR: a metabolic regulator and cell protector. Cell Research. 18: 1087-95. PMID 18825165 DOI: 10.1038/cr.2008.289  0.56
2008 Blanco-Bose WE, Murphy MJ, Ehninger A, Offner S, Dubey C, Huang W, Moore DD, Trumpp A. C-Myc and its target FoxM1 are critical downstream effectors of constitutive androstane receptor (CAR) mediated direct liver hyperplasia. Hepatology (Baltimore, Md.). 48: 1302-11. PMID 18798339 DOI: 10.1002/hep.22475  0.92
2008 Del Bas JM, Ricketts ML, Baiges I, Quesada H, Ardevol A, Salvadó MJ, Pujadas G, Blay M, Arola L, Bladé C, Moore DD, Fernandez-Larrea J. Dietary procyanidins lower triglyceride levels signaling through the nuclear receptor small heterodimer partner. Molecular Nutrition & Food Research. 52: 1172-81. PMID 18720348 DOI: 10.1002/mnfr.200800054  0.92
2008 Kleiner HE, Xia X, Sonoda J, Zhang J, Pontius E, Abey J, Evans RM, Moore DD, DiGiovanni J. Effects of naturally occurring coumarins on hepatic drug-metabolizing enzymes in mice. Toxicology and Applied Pharmacology. 232: 337-50. PMID 18692084 DOI: 10.1016/j.taap.2008.07.004  0.92
2008 Zhang Y, Xu P, Park K, Choi Y, Moore DD, Wang L. Orphan receptor small heterodimer partner suppresses tumorigenesis by modulating cyclin D1 expression and cellular proliferation. Hepatology (Baltimore, Md.). 48: 289-98. PMID 18537191 DOI: 10.1002/hep.22342  0.64
2008 Lee YK, Moore DD. Liver receptor homolog-1, an emerging metabolic modulator. Frontiers in Bioscience : a Journal and Virtual Library. 13: 5950-8. PMID 18508634 DOI: 10.2741/3128  0.68
2008 Merrell MD, Jackson JP, Augustine LM, Fisher CD, Slitt AL, Maher JM, Huang W, Moore DD, Zhang Y, Klaassen CD, Cherrington NJ. The Nrf2 activator oltipraz also activates the constitutive androstane receptor. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 1716-21. PMID 18474683 DOI: 10.1124/dmd.108.020867  0.92
2008 Masson D, Qatanani M, Sberna AL, Xiao R, Pais de Barros JP, Grober J, Deckert V, Athias A, Gambert P, Lagrost L, Moore DD, Assem M. Activation of the constitutive androstane receptor decreases HDL in wild-type and human apoA-I transgenic mice. Journal of Lipid Research. 49: 1682-91. PMID 18441373 DOI: 10.1194/jlr.M700374-JLR200  0.92
2008 Park YJ, Qatanani M, Chua SS, LaRey JL, Johnson SA, Watanabe M, Moore DD, Lee YK. Loss of orphan receptor small heterodimer partner sensitizes mice to liver injury from obstructive cholestasis. Hepatology (Baltimore, Md.). 47: 1578-86. PMID 18393320 DOI: 10.1002/hep.22196  0.92
2008 Roth A, Looser R, Kaufmann M, Blättler SM, Rencurel F, Huang W, Moore DD, Meyer UA. Regulatory cross-talk between drug metabolism and lipid homeostasis: constitutive androstane receptor and pregnane X receptor increase Insig-1 expression. Molecular Pharmacology. 73: 1282-9. PMID 18187584 DOI: 10.1124/mol.107.041012  0.56
2007 Carter BA, Taylor OA, Prendergast DR, Zimmerman TL, Von Furstenberg R, Moore DD, Karpen SJ. Stigmasterol, a soy lipid-derived phytosterol, is an antagonist of the bile acid nuclear receptor FXR. Pediatric Research. 62: 301-6. PMID 17622954 DOI: 10.1203/PDR.0b013e3181256492  0.92
2007 Huang J, Iqbal J, Saha PK, Liu J, Chan L, Hussain MM, Moore DD, Wang L. Molecular characterization of the role of orphan receptor small heterodimer partner in development of fatty liver. Hepatology (Baltimore, Md.). 46: 147-57. PMID 17526026 DOI: 10.1002/hep.21632  0.68
2007 Hernandez JP, Huang W, Chapman LM, Chua S, Moore DD, Baldwin WS. The environmental estrogen, nonylphenol, activates the constitutive androstane receptor. Toxicological Sciences : An Official Journal of the Society of Toxicology. 98: 416-26. PMID 17483497 DOI: 10.1093/toxsci/kfm107  0.92
2007 Ricketts ML, Boekschoten MV, Kreeft AJ, Hooiveld GJ, Moen CJ, Müller M, Frants RR, Kasanmoentalib S, Post SM, Princen HM, Porter JG, Katan MB, Hofker MH, Moore DD. The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors. Molecular Endocrinology (Baltimore, Md.). 21: 1603-16. PMID 17456796 DOI: 10.1210/me.2007-0133  0.92
2007 Yang F, Huang X, Yi T, Yen Y, Moore DD, Huang W. Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor. Cancer Research. 67: 863-7. PMID 17283114 DOI: 10.1158/0008-5472.CAN-06-1078  0.56
2007 Farhana L, Dawson MI, Leid M, Wang L, Moore DD, Liu G, Xia Z, Fontana JA. Adamantyl-substituted retinoid-related molecules bind small heterodimer partner and modulate the Sin3A repressor. Cancer Research. 67: 318-25. PMID 17210713 DOI: 10.1158/0008-5472.CAN-06-2164  0.64
2007 Anakk S, Huang W, Staudinger JL, Tan K, Cole TJ, Moore DD, Strobel HW. Gender dictates the nuclear receptor-mediated regulation of CYP3A44. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 36-42. PMID 17020958 DOI: 10.1124/dmd.106.011270  0.92
2006 Moore DD, Kato S, Xie W, Mangelsdorf DJ, Schmidt DR, Xiao R, Kliewer SA. International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor. Pharmacological Reviews. 58: 742-59. PMID 17132852 DOI: 10.1124/pr.58.4.6  0.92
2006 Wang L, Huang J, Saha P, Kulkarni RN, Hu M, Kim Y, Park K, Chan L, Rajan AS, Lee I, Moore DD. Orphan receptor small heterodimer partner is an important mediator of glucose homeostasis. Molecular Endocrinology (Baltimore, Md.). 20: 2671-81. PMID 16803864 DOI: 10.1210/me.2006-0224  0.64
2006 Baskin-Bey ES, Huang W, Ishimura N, Isomoto H, Bronk SF, Braley K, Craig RW, Moore DD, Gores GJ. Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins. Hepatology (Baltimore, Md.). 44: 252-62. PMID 16799968 DOI: 10.1002/hep.21236  0.56
2006 Huang W, Ma K, Zhang J, Qatanani M, Cuvillier J, Liu J, Dong B, Huang X, Moore DD. Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration. Science (New York, N.Y.). 312: 233-6. PMID 16614213 DOI: 10.1126/science.1121435  0.56
2006 Ma K, Saha PK, Chan L, Moore DD. Farnesoid X receptor is essential for normal glucose homeostasis. The Journal of Clinical Investigation. 116: 1102-9. PMID 16557297 DOI: 10.1172/JCI25604  0.68
2006 Lee YK, Choi YH, Chua S, Park YJ, Moore DD. Phosphorylation of the hinge domain of the nuclear hormone receptor LRH-1 stimulates transactivation. The Journal of Biological Chemistry. 281: 7850-5. PMID 16439367 DOI: 10.1074/jbc.M509115200  0.72
2006 Datta S, Wang L, Moore DD, Osborne TF. Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase promoter by nuclear receptors liver receptor homologue-1 and small heterodimer partner: a mechanism for differential regulation of cholesterol synthesis and uptake. The Journal of Biological Chemistry. 281: 807-12. PMID 16282330 DOI: 10.1074/jbc.M511050200  0.64
2005 Columbano A, Ledda-Columbano GM, Pibiri M, Cossu C, Menegazzi M, Moore DD, Huang W, Tian J, Locker J. Gadd45beta is induced through a CAR-dependent, TNF-independent pathway in murine liver hyperplasia. Hepatology (Baltimore, Md.). 42: 1118-26. PMID 16231353 DOI: 10.1002/hep.20883  0.56
2005 Wang L, Liu J, Saha P, Huang J, Chan L, Spiegelman B, Moore DD. The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes. Cell Metabolism. 2: 227-38. PMID 16213225 DOI: 10.1016/j.cmet.2005.08.010  0.92
2005 Ricketts ML, Moore DD, Banz WJ, Mezei O, Shay NF. Molecular mechanisms of action of the soy isoflavones includes activation of promiscuous nuclear receptors. A review. The Journal of Nutritional Biochemistry. 16: 321-30. PMID 15936643 DOI: 10.1016/j.jnutbio.2004.11.008  0.92
2005 Huang W, Zhang J, Washington M, Liu J, Parant JM, Lozano G, Moore DD. Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor. Molecular Endocrinology (Baltimore, Md.). 19: 1646-53. PMID 15831521 DOI: 10.1210/me.2004-0520  0.92
2005 Ortlund EA, Lee Y, Solomon IH, Hager JM, Safi R, Choi Y, Guan Z, Tripathy A, Raetz CR, McDonnell DP, Moore DD, Redinbo MR. Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. Nature Structural & Molecular Biology. 12: 357-63. PMID 15723037 DOI: 10.1038/nsmb910  0.92
2005 Stedman CA, Liddle C, Coulter SA, Sonoda J, Alvarez JG, Moore DD, Evans RM, Downes M. Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury. Proceedings of the National Academy of Sciences of the United States of America. 102: 2063-8. PMID 15684063 DOI: 10.1073/pnas.0409794102  0.92
2005 Qatanani M, Zhang J, Moore DD. Role of the constitutive androstane receptor in xenobiotic-induced thyroid hormone metabolism. Endocrinology. 146: 995-1002. PMID 15564320 DOI: 10.1210/en.2004-1350  0.52
2004 Zhang J, Huang W, Qatanani M, Evans RM, Moore DD. The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity. The Journal of Biological Chemistry. 279: 49517-22. PMID 15358766 DOI: 10.1074/jbc.M409041200  0.56
2004 Huang W, Zhang J, Wei P, Schrader WT, Moore DD. Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR. Molecular Endocrinology (Baltimore, Md.). 18: 2402-8. PMID 15272053 DOI: 10.1210/me.2004-0046  0.56
2004 Qatanani M, Wei P, Moore DD. Alterations in the distribution and orexigenic effects of dexamethasone in CAR-null mice. Pharmacology, Biochemistry, and Behavior. 78: 285-91. PMID 15219769 DOI: 10.1016/j.pbb.2004.04.001  0.52
2004 Watanabe M, Houten SM, Wang L, Moschetta A, Mangelsdorf DJ, Heyman RA, Moore DD, Auwerx J. Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. The Journal of Clinical Investigation. 113: 1408-18. PMID 15146238 DOI: 10.1172/JCI21025  0.64
2004 Assem M, Schuetz EG, Leggas M, Sun D, Yasuda K, Reid G, Zelcer N, Adachi M, Strom S, Evans RM, Moore DD, Borst P, Schuetz JD. Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice. The Journal of Biological Chemistry. 279: 22250-7. PMID 15004017 DOI: 10.1074/jbc.M314111200  0.92
2004 Saini SP, Sonoda J, Xu L, Toma D, Uppal H, Mu Y, Ren S, Moore DD, Evans RM, Xie W. A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification. Molecular Pharmacology. 65: 292-300. PMID 14742670 DOI: 10.1124/mol.65.2.292  0.92
2004 Huang W, Zhang J, Moore DD. A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR. The Journal of Clinical Investigation. 113: 137-43. PMID 14702117 DOI: 10.1172/JCI18385  0.56
2003 Lee YK, Moore DD. The orphan receptor SHP and the three-hybrid interference assay. Methods in Enzymology. 364: 152-9. PMID 14631844 DOI: 10.1016/s0076-6879(03)64009-7  0.68
2003 Cherrington NJ, Slitt AL, Maher JM, Zhang XX, Zhang J, Huang W, Wan YJ, Moore DD, Klaassen CD. Induction of multidrug resistance protein 3 (mrp3) in vivo is independent of constitutive androstane receptor. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 1315-9. PMID 14570762 DOI: 10.1124/dmd.31.11.1315  0.92
2003 Wang L, Han Y, Kim CS, Lee YK, Moore DD. Resistance of SHP-null mice to bile acid-induced liver damage. The Journal of Biological Chemistry. 278: 44475-81. PMID 12933814 DOI: 10.1074/jbc.M305258200  0.68
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