Lorraine Young - Publications

Wolfson Centre for Stem Cells, Tissue Engineering and Mathematical Modelling University of Nottingham, Nottingham, England, United Kingdom 

41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Abakir A, Giles TC, Cristini A, Foster JM, Dai N, Starczak M, Rubio-Roldan A, Li M, Eleftheriou M, Crutchley J, Flatt L, Young L, Gaffney DJ, Denning C, Dalhus B, et al. N-methyladenosine regulates the stability of RNA:DNA hybrids in human cells. Nature Genetics. PMID 31844323 DOI: 10.1038/S41588-019-0549-X  1
2016 Hammad M, Rao W, Smith JG, Anderson DG, Langer R, Young LE, Barrett DA, Davies MC, Denning C, Alexander MR. Identification of polymer surface adsorbed proteins implicated in pluripotent human embryonic stem cell expansion. Biomaterials Science. PMID 27466628 DOI: 10.1039/C6Bm00214E  1
2015 Denning C, Borgdorff V, Crutchley J, Firth KS, George V, Kalra S, Kondrashov A, Hoang MD, Mosqueira D, Patel A, Prodanov L, Rajamohan D, Skarnes WC, Smith JG, Young LE. Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform. Biochimica Et Biophysica Acta. PMID 26524115 DOI: 10.1016/J.Bbamcr.2015.10.014  1
2015 Celiz AD, Smith JG, Patel AK, Hook AL, Rajamohan D, George VT, Flatt L, Patel MJ, Epa VC, Singh T, Langer R, Anderson DG, Allen ND, Hay DC, Winkler DA, ... ... Young LE, et al. Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation. Advanced Materials (Deerfield Beach, Fla.). 27: 4006-12. PMID 26033422 DOI: 10.1002/Adma.201501351  1
2014 Celiz AD, Smith JG, Patel AK, Langer R, Anderson DG, Barrett DA, Young LE, Davies MC, Denning C, Alexander MR. Chemically diverse polymer microarrays and high throughput surface characterisation: a method for discovery of materials for stem cell culture†Electronic supplementary information (ESI) available. See DOI: 10.1039/c4bm00054dClick here for additional data file. Biomaterials Science. 2: 1604-1611. PMID 25328672 DOI: 10.1039/C4Bm00054D  1
2014 Celiz AD, Smith JG, Langer R, Anderson DG, Winkler DA, Barrett DA, Davies MC, Young LE, Denning C, Alexander MR. Materials for stem cell factories of the future. Nature Materials. 13: 570-9. PMID 24845996 DOI: 10.1038/Nmat3972  1
2012 Almeida RD, Loose M, Sottile V, Matsa E, Denning C, Young L, Johnson AD, Gering M, Ruzov A. 5-hydroxymethyl-cytosine enrichment of non-committed cells is not a universal feature of vertebrate development. Epigenetics : Official Journal of the Dna Methylation Society. 7: 383-9. PMID 22419071 DOI: 10.4161/Epi.19375  1
2011 Dick E, Matsa E, Young LE, Darling D, Denning C. Faster generation of hiPSCs by coupling high-titer lentivirus and column-based positive selection. Nature Protocols. 6: 701-14. PMID 21637193 DOI: 10.1038/Nprot.2011.320  1
2011 Matsa E, Rajamohan D, Dick E, Young L, Mellor I, Staniforth A, Denning C. Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation. European Heart Journal. 32: 952-62. PMID 21367833 DOI: 10.1093/Eurheartj/Ehr073  1
2011 Dick E, Matsa E, Bispham J, Reza M, Guglieri M, Staniforth A, Watson S, Kumari R, Lochmüller H, Young L, Darling D, Denning C. Two new protocols to enhance the production and isolation of human induced pluripotent stem cell lines. Stem Cell Research. 6: 158-67. PMID 21095172 DOI: 10.1016/J.Scr.2010.10.002  1
2010 Priddle H, Allegrucci C, Burridge P, Munoz M, Smith NM, Devlin L, Sjoblom C, Chamberlain S, Watson S, Young LE, Denning C. Derivation and characterisation of the human embryonic stem cell lines, NOTT1 and NOTT2. In Vitro Cellular & Developmental Biology. Animal. 46: 367-75. PMID 20177995 DOI: 10.1007/S11626-010-9290-6  1
2009 Priddle H, Grabowska A, Morris T, Clarke PA, McKenzie AJ, Sottile V, Denning C, Young L, Watson S. Bioluminescence imaging of human embryonic stem cells transplanted in vivo in murine and chick models. Cloning and Stem Cells. 11: 259-67. PMID 19522673 DOI: 10.1089/Clo.2008.0056  1
2009 Thomas RJ, Anderson D, Chandra A, Smith NM, Young LE, Williams D, Denning C. Automated, scalable culture of human embryonic stem cells in feeder-free conditions. Biotechnology and Bioengineering. 102: 1636-44. PMID 19062183 DOI: 10.1002/Bit.22187  1
2008 Braam SR, Denning C, Matsa E, Young LE, Passier R, Mummery CL. Feeder-free culture of human embryonic stem cells in conditioned medium for efficient genetic modification. Nature Protocols. 3: 1435-43. PMID 18772870 DOI: 10.1038/Nprot.2008.140  1
2008 Thurston A, Taylor J, Gardner J, Sinclair KD, Young LE. Monoallelic expression of nine imprinted genes in the sheep embryo occurs after the blastocyst stage. Reproduction (Cambridge, England). 135: 29-40. PMID 18159081 DOI: 10.1530/REP-07-0211  1
2007 Sinclair KD, Allegrucci C, Singh R, Gardner DS, Sebastian S, Bispham J, Thurston A, Huntley JF, Rees WD, Maloney CA, Lea RG, Craigon J, McEvoy TG, Young LE. DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status. Proceedings of the National Academy of Sciences of the United States of America. 104: 19351-6. PMID 18042717 DOI: 10.1073/pnas.0707258104  1
2007 Kim KP, Thurston A, Mummery C, Ward-van Oostwaard D, Priddle H, Allegrucci C, Denning C, Young L. Gene-specific vulnerability to imprinting variability in human embryonic stem cell lines. Genome Research. 17: 1731-42. PMID 17989250 DOI: 10.1101/Gr.6609207  1
2007 Thurston A, Lucas ES, Allegrucci C, Steele W, Young LE. Region-specific DNA methylation in the preimplantation embryo as a target for genomic plasticity. Theriogenology. 68: S98-106. PMID 17482250 DOI: 10.1016/j.theriogenology.2007.03.020  1
2007 Allegrucci C, Wu YZ, Thurston A, Denning CN, Priddle H, Mummery CL, Ward-van Oostwaard D, Andrews PW, Stojkovic M, Smith N, Parkin T, Jones ME, Warren G, Yu L, Brena RM, ... ... Young LE, et al. Restriction landmark genome scanning identifies culture-induced DNA methylation instability in the human embryonic stem cell epigenome. Human Molecular Genetics. 16: 1253-68. PMID 17409196 DOI: 10.1093/Hmg/Ddm074  1
2007 Burridge PW, Anderson D, Priddle H, Barbadillo Muñoz MD, Chamberlain S, Allegrucci C, Young LE, Denning C. Improved human embryonic stem cell embryoid body homogeneity and cardiomyocyte differentiation from a novel V-96 plate aggregation system highlights interline variability. Stem Cells (Dayton, Ohio). 25: 929-38. PMID 17185609 DOI: 10.1634/Stemcells.2006-0598  1
2007 Allegrucci C, Young LE. Differences between human embryonic stem cell lines. Human Reproduction Update. 13: 103-20. PMID 16936306 DOI: 10.1093/humupd/dml041  1
2007 Young LE, Denning C. Oct4 during the pluripotency differentiation transition: Who is regulating the regulator? Regenerative Medicine. 2: 211-215. DOI: 10.2217/17460751.2.2.211  1
2006 Young LE. Focus on stem cells in reproduction. Reproduction (Cambridge, England). 132: 671-2. PMID 17071767 DOI: 10.1530/REP-06-0191  1
2006 Powell K, Rooke JA, McEvoy TG, Ashworth CJ, Robinson JJ, Wilmut I, Young LE, Sinclair KD. Zygote donor nitrogen metabolism and in vitro embryo culture perturbs in utero development and IGF2R expression in ovine fetal tissues. Theriogenology. 66: 1901-12. PMID 16777210 DOI: 10.1016/j.theriogenology.2006.05.008  1
2006 Moore HR, Meehan RR, Young LE. Methylation-sensitive polymerase chain reaction. Methods in Molecular Biology (Clifton, N.J.). 325: 239-49. PMID 16761730 DOI: 10.1385/1-59745-005-7:239  1
2006 Denning C, Allegrucci C, Priddle H, Barbadillo-Muñoz MD, Anderson D, Self T, Smith NM, Parkin CT, Young LE. Common culture conditions for maintenance and cardiomyocyte differentiation of the human embryonic stem cell lines, BG01 and HUES-7. The International Journal of Developmental Biology. 50: 27-37. PMID 16323075 DOI: 10.1387/Ijdb.052107Cd  1
2005 Goh G, Self T, Barbadillo Muñoz MD, Hall IP, Young L, Denning C. Molecular and phenotypic analyses of human embryonic stem cell-derived cardiomyocytes: opportunities and challenges for clinical translation. Thrombosis and Haemostasis. 94: 728-37. PMID 16270624 DOI: 10.1160/Th05-04-0268  1
2005 Allegrucci C, Denning CN, Burridge P, Steele W, Sinclair KD, Young LE. Human embryonic stem cells as a model for nutritional programming: an evaluation. Reproductive Toxicology (Elmsford, N.Y.). 20: 353-67. PMID 15975761 DOI: 10.1016/J.Reprotox.2005.04.010  1
2005 Steele W, Allegrucci C, Singh R, Lucas E, Priddle H, Denning C, Sinclair K, Young L. Human embryonic stem cell methyl cycle enzyme expression: modelling epigenetic programming in assisted reproduction? Reproductive Biomedicine Online. 10: 755-66. PMID 15970006 DOI: 10.1016/S1472-6483(10)61120-0  1
2005 Allegrucci C, Thurston A, Lucas E, Young L. Epigenetics and the germline. Reproduction (Cambridge, England). 129: 137-49. PMID 15695608 DOI: 10.1530/Rep.1.00360  0.6
2004 Young LE, Beaujean N. DNA methylation in the preimplantation embryo: the differing stories of the mouse and sheep. Animal Reproduction Science. 82: 61-78. PMID 15271444 DOI: 10.1016/j.anireprosci.2004.05.020  1
2004 Allegrucci C, Denning C, Priddle H, Young L. Stem-cell consequences of embryo epigenetic defects. Lancet. 364: 206-8. PMID 15246736 DOI: 10.1016/S0140-6736(04)16636-1  1
2003 Young LE, Schnieke AE, McCreath KJ, Wieckowski S, Konfortova G, Fernandes K, Ptak G, Kind AJ, Wilmut I, Loi P, Feil R. Conservation of IGF2-H19 and IGF2R imprinting in sheep: effects of somatic cell nuclear transfer. Mechanisms of Development. 120: 1433-42. PMID 14654216 DOI: 10.1016/j.mod.2003.09.006  1
2003 Young LE. Scientific hazards of human reproductive 'cloning'. Human Fertility (Cambridge, England). 6: 59-63. PMID 12869785 DOI: 10.1080/1464770312331369053  1
2002 Fairburn HR, Young LE, Hendrich BD. Epigenetic reprogramming: how now, cloned cow? Current Biology : Cb. 12: R68-70. PMID 11818083 DOI: 10.1016/S0960-9822(01)00677-7  1
2001 Young LE. Imprinting of genes and the Barker hypothesis. Twin Research : the Official Journal of the International Society For Twin Studies. 4: 307-17. PMID 11869481 DOI: 10.1375/1369052012632  1
2001 Young LE, Fernandes K, McEvoy TG, Butterwith SC, Gutierrez CG, Carolan C, Broadbent PJ, Robinson JJ, Wilmut I, Sinclair KD. Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture. Nature Genetics. 27: 153-4. PMID 11175780 DOI: 10.1038/84769  1
2000 McEvoy TG, Sinclair KD, Young LE, Wilmut I, Robinson JJ. Large offspring syndrome and other consequences of ruminant embryo culture in vitro: relevance to blastocyst culture in human ART. Human Fertility (Cambridge, England). 3: 238-246. PMID 11844385  1
2000 Sinclair KD, Young LE, Wilmut I, McEvoy TG. In-utero overgrowth in ruminants following embryo culture: lessons from mice and a warning to men. Human Reproduction (Oxford, England). 15: 68-86. PMID 11263539 DOI: 10.1093/HUMREP/15.SUPPL_5.68  1
2000 Young LE, Fairburn HR. Improving the safety of embryo technologies: possible role of genomic imprinting. Theriogenology. 53: 627-48. PMID 10735055 DOI: 10.1016/S0093-691X(99)00263-0  1
1998 Young LE, Sinclair KD, Wilmut I. Large offspring syndrome in cattle and sheep. Reviews of Reproduction. 3: 155-63. PMID 9829550 DOI: 10.1530/ror.0.0030155  1
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