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Timothy L. Macdonald - Publications

Chemistry University of Virginia, Charlottesville, VA 
Bioorganic and Synthetic Organic Chemistry

191 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Houck JD, Dawson TK, Kennedy AJ, Kharel Y, Naimon ND, Field SD, Lynch KR, Macdonald TL. Structural Requirements and Docking Analysis of Amidine-Based Sphingosine Kinase 1 Inhibitors Containing Oxadiazoles. Acs Medicinal Chemistry Letters. 7: 487-92. PMID 27190598 DOI: 10.1021/Acsmedchemlett.6B00002  0.48
2016 Kennedy AJ, Bruce AM, Gineste C, Ballard TE, Olekhnovich IN, Macdonald TL, Hoffman PS. Synthesis and Antimicrobial Evaluation of Amixicile-Based Inhibitors of the Pyruvate: Ferredoxin Oxidoreductases of Anaerobic Bacteria and Epsilon Proteobacteria. Antimicrobial Agents and Chemotherapy. PMID 27090174 DOI: 10.1128/Aac.00670-16  0.48
2014 Hoffman PS, Bruce AM, Olekhnovich I, Warren CA, Burgess SL, Hontecillas R, Viladomiu M, Bassaganya-Riera J, Guerrant RL, Macdonald TL. Preclinical studies of amixicile, a systemic therapeutic developed for treatment of Clostridium difficile infections that also shows efficacy against Helicobacter pylori. Antimicrobial Agents and Chemotherapy. 58: 4703-12. PMID 24890599 DOI: 10.1128/Aac.03112-14  1
2013 Gray LS, Schiff D, Macdonald TL. A model for the regulation of T-type Ca2+ channels in proliferation: Roles in stem cells and cancer Expert Review of Anticancer Therapy. 13: 589-595. PMID 23617350 DOI: 10.1586/Era.13.34  1
2013 Peyruchaud O, David M, Macdonald TL, Lynch KR. Lysophosphatidic Acid (LPA) Signaling and Bone Cancer Lysophospholipid Receptors: Signaling and Biochemistry. 627-640. DOI: 10.1002/9781118531426.ch29  1
2012 East JE, Macdonald TL. Cost-effective and Large-scale synthesis of 16:0 Lysophosphatidic Acid. Synthetic Communications. 42: 3614-3618. PMID 23264701 DOI: 10.1080/00397911.2011.587080  0.8
2012 Warren CA, van Opstal E, Ballard TE, Kennedy A, Wang X, Riggins M, Olekhnovich I, Warthan M, Kolling GL, Guerrant RL, Macdonald TL, Hoffman PS. Amixicile, a novel inhibitor of pyruvate: ferredoxin oxidoreductase, shows efficacy against Clostridium difficile in a mouse infection model. Antimicrobial Agents and Chemotherapy. 56: 4103-11. PMID 22585229 DOI: 10.1128/Aac.00360-12  1
2012 East JE, MacDonald TL. Cost-effective and large-scale synthesis of 16:0 lysophosphatidic acid Synthetic Communications. 42: 3614-3619. DOI: 10.1080/00397911.2011.587080  1
2011 East JE, Carter KM, Kennedy PC, Schulte NA, Toews ML, Lynch KR, Macdonald TL. Development of a phosphatase-resistant, L-tyrosine derived LPA1/LPA3 dual antagonist. Medchemcomm. 2: 325-330. PMID 22180836 DOI: 10.1039/C0Md00273A  1
2011 Kharel Y, Mathews TP, Gellett AM, Tomsig JL, Kennedy PC, Moyer ML, Macdonald TL, Lynch KR. Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate. The Biochemical Journal. 440: 345-53. PMID 21848514 DOI: 10.1042/Bj20110817  1
2011 Kennedy PC, Zhu R, Huang T, Tomsig JL, Mathews TP, David M, Peyruchaud O, Macdonald TL, Lynch KR. Characterization of a sphingosine 1-phosphate receptor antagonist prodrug. The Journal of Pharmacology and Experimental Therapeutics. 338: 879-89. PMID 21632869 DOI: 10.1124/Jpet.111.181552  1
2011 Kennedy AJ, Mathews TP, Kharel Y, Field SD, Moyer ML, East JE, Houck JD, Lynch KR, Macdonald TL. Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells. Journal of Medicinal Chemistry. 54: 3524-48. PMID 21495716 DOI: 10.1021/Jm2001053  1
2011 Ballard TE, Wang X, Olekhnovich I, Koerner T, Seymour C, Salamoun J, Warthan M, Hoffman PS, Macdonald TL. Synthesis and antimicrobial evaluation of nitazoxanide-based analogues: identification of selective and broad spectrum activity. Chemmedchem. 6: 362-77. PMID 21275058 DOI: 10.1002/Cmdc.201000475  1
2011 Kharel Y, Mathews TP, Kennedy AJ, Houck JD, Macdonald TL, Lynch KR. A rapid assay for assessment of sphingosine kinase inhibitors and substrates. Analytical Biochemistry. 411: 230-5. PMID 21216217 DOI: 10.1016/J.Ab.2011.01.003  1
2011 Sefcik LS, Aronin CE, Awojoodu AO, Shin SJ, Mac Gabhann F, MacDonald TL, Wamhoff BR, Lynch KR, Peirce SM, Botchwey EA. Selective activation of sphingosine 1-phosphate receptors 1 and 3 promotes local microvascular network growth. Tissue Engineering. Part A. 17: 617-29. PMID 20874260 DOI: 10.1089/Ten.Tea.2010.0404  1
2010 East JE, Kennedy AJ, Tomsig JL, De Leon AR, Lynch KR, Macdonald TL. Synthesis and structure-activity relationships of tyrosine-based inhibitors of autotaxin (ATX). Bioorganic & Medicinal Chemistry Letters. 20: 7132-6. PMID 20951039 DOI: 10.1016/J.Bmcl.2010.09.030  1
2010 Yang M, Chordia MD, Li F, Huang T, Linden J, MacDonald TL. Neutrophil- and myeloperoxidase-mediated metabolism of reduced nimesulide: Evidence for bioactivation Chemical Research in Toxicology. 23: 1691-1700. PMID 20939553 DOI: 10.1021/Tx1001496  1
2010 Ballard TE, Wang X, Olekhnovich I, Koerner T, Seymour C, Hoffman PS, Macdonald TL. Biological activity of modified and exchanged 2-amino-5-nitrothiazole amide analogues of nitazoxanide. Bioorganic & Medicinal Chemistry Letters. 20: 3537-9. PMID 20488706 DOI: 10.1016/J.Bmcl.2010.04.126  1
2010 Tchouaffi-Nana F, Ballard TE, Cary CH, Macdonald TL, Sifri CD, Hoffman PS. Nitazoxanide inhibits biofilm formation by Staphylococcus epidermidis by blocking accumulation on surfaces. Antimicrobial Agents and Chemotherapy. 54: 2767-74. PMID 20404119 DOI: 10.1128/Aac.00901-09  1
2010 Bajwa A, Jo SK, Ye H, Huang L, Dondeti KR, Rosin DL, Haase VH, Macdonald TL, Lynch KR, Okusa MD. Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury. Journal of the American Society of Nephrology : Jasn. 21: 955-65. PMID 20338995 DOI: 10.1681/Asn.2009060662  1
2010 Mathews TP, Kennedy AJ, Kharel Y, Kennedy PC, Nicoara O, Sunkara M, Morris AJ, Wamhoff BR, Lynch KR, Macdonald TL. Discovery, biological evaluation, and structure-activity relationship of amidine based sphingosine kinase inhibitors. Journal of Medicinal Chemistry. 53: 2766-78. PMID 20205392 DOI: 10.1021/Jm901860H  1
2010 Ma B, Guckian KM, Lin EY, Lee WC, Scott D, Kumaravel G, Macdonald TL, Lynch KR, Black C, Chollate S, Hahm K, Hetu G, Jin P, Luo Y, Rohde E, et al. Stereochemistry-activity relationship of orally active tetralin S1P agonist prodrugs. Bioorganic & Medicinal Chemistry Letters. 20: 2264-9. PMID 20188554 DOI: 10.1016/J.Bmcl.2010.02.006  1
2010 Petrie Aronin CE, Sefcik LS, Tholpady SS, Tholpady A, Sadik KW, Macdonald TL, Peirce SM, Wamhoff BR, Lynch KR, Ogle RC, Botchwey EA. FTY720 promotes local microvascular network formation and regeneration of cranial bone defects. Tissue Engineering. Part A. 16: 1801-9. PMID 20038198 DOI: 10.1089/Ten.Tea.2009.0539  1
2009 Cross JV, Rady JM, Foss FW, Lyons CE, Macdonald TL, Templeton DJ. Nutrient isothiocyanates covalently modify and inhibit the inflammatory cytokine macrophage migration inhibitory factor (MIF) Biochemical Journal. 423: 315-321. PMID 19723024 DOI: 10.1042/Bj20091170  1
2009 Foss FW, Mathews TP, Kharel Y, Kennedy PC, Snyder AH, Davis MD, Lynch KR, Macdonald TL. Synthesis and biological evaluation of sphingosine kinase substrates as sphingosine-1-phosphate receptor prodrugs. Bioorganic & Medicinal Chemistry. 17: 6123-36. PMID 19632123 DOI: 10.1016/J.Bmc.2009.04.015  1
2009 Sim-Selley LJ, Goforth PB, Mba MU, Macdonald TL, Lynch KR, Milstien S, Spiegel S, Satin LS, Welch SP, Selley DE. Sphingosine-1-phosphate receptors mediate neuromodulatory functions in the CNS. Journal of Neurochemistry. 110: 1191-202. PMID 19493165 DOI: 10.1111/J.1471-4159.2009.06202.X  1
2009 Joshi EM, Heasley BH, MacDonald TL. 2-ABT-S-oxide detoxification by glutathione S-transferases A1-1, M1-1 and P1-1: Implications for toxicity associated with zileuton Xenobiotica. 39: 197-204. PMID 19280518 DOI: 10.1080/00498250802651976  1
2009 Gaetano CG, Samadi N, Tomsig JL, Macdonald TL, Lynch KR, Brindley DN. Inhibition of autotaxin production or activity blocks lysophosphatidylcholine-induced migration of human breast cancer and melanoma cells. Molecular Carcinogenesis. 48: 801-9. PMID 19204929 DOI: 10.1002/Mc.20524  1
2009 Li F, Chordia MD, Huang T, Macdonald TL. In vitro nimesulide studies toward understanding idiosyncratic hepatotoxicity: Diiminoquinone formation and conjugation Chemical Research in Toxicology. 22: 72-80. PMID 19053182 DOI: 10.1021/Tx800152R  1
2008 Lynch KR, Macdonald TL. Sphingosine 1-phosphate chemical biology. Biochimica Et Biophysica Acta. 1781: 508-12. PMID 18638568 DOI: 10.1016/J.Bbalip.2008.06.006  1
2008 Wamhoff BR, Lynch KR, Macdonald TL, Owens GK. Sphingosine-1-phosphate receptor subtypes differentially regulate smooth muscle cell phenotype. Arteriosclerosis, Thrombosis, and Vascular Biology. 28: 1454-61. PMID 18535287 DOI: 10.1161/Atvbaha.107.159392  1
2008 Deveau AM, Costa NE, Joshi EM, Macdonald TL. Synthesis of diketopiperazine-based carboline homodimers and in vitro growth inhibition of human carcinomas Bioorganic and Medicinal Chemistry Letters. 18: 3522-3525. PMID 18502124 DOI: 10.1016/J.Bmcl.2008.05.022  1
2008 Jain HD, Zhang C, Zhou S, Zhou H, Ma J, Liu X, Liao X, Deveau AM, Dieckhaus CM, Johnson MA, Smith KS, Macdonald TL, Kakeya H, Osada H, Cook JM. Synthesis and structure-activity relationship studies on tryprostatin A, an inhibitor of breast cancer resistance protein. Bioorganic & Medicinal Chemistry. 16: 4626-51. PMID 18321710 DOI: 10.1016/J.Bmc.2008.02.050  1
2008 Sun Q, Zhu R, Foss FW, Macdonald TL. In vitro metabolism of a model cyclopropylamine to reactive intermediate: Insights into trovafloxacin-induced hepatotoxicity Chemical Research in Toxicology. 21: 711-719. PMID 18298092 DOI: 10.1021/Tx7003085  1
2008 Cui P, McCalmont WF, Tomsig JL, Lynch KR, Macdonald TL. alpha- and beta-substituted phosphonate analogs of LPA as autotaxin inhibitors. Bioorganic & Medicinal Chemistry. 16: 2212-25. PMID 18082408 DOI: 10.1016/J.Bmc.2007.11.078  1
2007 Zhu R, Snyder AH, Kharel Y, Schaffter L, Sun Q, Kennedy PC, Lynch KR, Macdonald TL. Asymmetric synthesis of conformationally constrained fingolimod analogues--discovery of an orally active sphingosine 1-phosphate receptor type-1 agonist and receptor type-3 antagonist. Journal of Medicinal Chemistry. 50: 6428-35. PMID 17994678 DOI: 10.1021/Jm7010172  1
2007 Sun Q, Zhu R, Foss FW, Macdonald TL. Mechanisms of trovafloxacin hepatotoxicity: Studies of a model cyclopropylamine-containing system Bioorganic and Medicinal Chemistry Letters. 17: 6682-6686. PMID 17976985 DOI: 10.1016/J.Bmcl.2007.10.070  1
2007 Li F, Chordia MD, Woodling KA, Macdonald TL. Irreversible alkylation of human serum albumin by zileuton metabolite 2-acetylbenzothiophene-S-oxide: A potential model for hepatotoxicity Chemical Research in Toxicology. 20: 1854-1861. PMID 17944539 DOI: 10.1021/Tx7001417  1
2007 Cross JV, Foss FW, Rady JM, Macdonald TL, Templeton DJ. The isothiocyanate class of bioactive nutrients covalently inhibit the MEKK1 protein kinase Bmc Cancer. 7. PMID 17894894 DOI: 10.1186/1471-2407-7-183  1
2007 Palmer LA, Doctor A, Chhabra P, Sheram ML, Laubach VE, Karlinsey MZ, Forbes MS, Macdonald T, Gaston B. S-nitrosothiols signal hypoxia-mimetic vascular pathology. The Journal of Clinical Investigation. 117: 2592-601. PMID 17786245 DOI: 10.1172/Jci29444  1
2007 Glover DK, Ruiz M, Takehana K, Petruzella FD, Rieger JM, Macdonald TL, Watson DD, Linden J, Beller GA. Cardioprotection by adenosine A2A agonists in a canine model of myocardial stunning produced by multiple episodes of transient ischemia. American Journal of Physiology. Heart and Circulatory Physiology. 292: H3164-71. PMID 17308004 DOI: 10.1152/Ajpheart.00743.2005  1
2007 Cui P, Tomsig JL, McCalmont WF, Lee S, Becker CJ, Lynch KR, Macdonald TL. Synthesis and biological evaluation of phosphonate derivatives as autotaxin (ATX) inhibitors. Bioorganic & Medicinal Chemistry Letters. 17: 1634-40. PMID 17257836 DOI: 10.1016/J.Bmcl.2006.12.114  1
2007 Oo ML, Thangada S, Wu MT, Liu CH, Macdonald TL, Lynch KR, Lin CY, Hla T. Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor. The Journal of Biological Chemistry. 282: 9082-9. PMID 17237497 DOI: 10.1074/Jbc.M610318200  1
2007 Foss FW, Snyder AH, Davis MD, Rouse M, Okusa MD, Lynch KR, Macdonald TL. Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists. Bioorganic & Medicinal Chemistry. 15: 663-77. PMID 17113298 DOI: 10.1016/J.Bmc.2006.10.060  1
2006 Whetzel AM, Bolick DT, Srinivasan S, Macdonald TL, Morris MA, Ley K, Hedrick CC. Sphingosine-1 phosphate prevents monocyte/endothelial interactions in type 1 diabetic NOD mice through activation of the S1P1 receptor. Circulation Research. 99: 731-9. PMID 16960101 DOI: 10.1161/01.Res.0000244088.33375.52  1
2006 Gray LS, Macdonald TL. The pharmacology and regulation of T type calcium channels: New opportunities for unique therapeutics for cancer Cell Calcium. 40: 115-120. PMID 16806465 DOI: 10.1016/J.Ceca.2006.04.014  1
2006 Cui P, Macdonald TL, Chen M, Nadler JL. Synthesis and biological evaluation of lisofylline (LSF) analogs as a potential treatment for Type 1 diabetes Bioorganic and Medicinal Chemistry Letters. 16: 3401-3405. PMID 16650991 DOI: 10.1016/J.Bmcl.2006.04.036  1
2006 Zhu R, Frazier CR, Linden J, Macdonald TL. N6-ethyl-2-alkynyl NECAs, selective human A3 adenosine receptor agonists. Bioorganic & Medicinal Chemistry Letters. 16: 2416-8. PMID 16487705 DOI: 10.1016/J.Bmcl.2006.01.110  1
2006 Schonhoff CM, Matsuoka M, Tummala H, Johnson MA, Estevéz AG, Wu R, Kamaid A, Ricart KC, Hashimoto Y, Gaston B, Macdonald TL, Xu Z, Mannick JB. S-nitrosothiol depletion in amyotrophic lateral sclerosis. Proceedings of the National Academy of Sciences of the United States of America. 103: 2404-9. PMID 16461917 DOI: 10.1073/Pnas.0507243103  1
2006 Zaman K, Hanigan MH, Smith A, Vaughan J, Macdonald T, Jones DR, Hunt JF, Gaston B. Endogenous S-nitrosoglutathione modifies 5-lipoxygenase expression in airway epithelial cells. American Journal of Respiratory Cell and Molecular Biology. 34: 387-93. PMID 16415251 DOI: 10.1165/Rcmb.2005-0336Rc  1
2006 Awad AS, Ye H, Huang L, Li L, Foss FW, Macdonald TL, Lynch KR, Okusa MD. Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney. American Journal of Physiology. Renal Physiology. 290: F1516-24. PMID 16403835 DOI: 10.1152/Ajprenal.00311.2005  1
2005 Foss FW, Clemens JJ, Davis MD, Snyder AH, Zigler MA, Lynch KR, Macdonald TL. Synthesis, stability, and implications of phosphothioate agonists of sphingosine-1-phosphate receptors. Bioorganic & Medicinal Chemistry Letters. 15: 4470-4. PMID 16125386 DOI: 10.1016/J.Bmcl.2005.07.057  1
2005 Kharel Y, Lee S, Snyder AH, Sheasley-O'neill SL, Morris MA, Setiady Y, Zhu R, Zigler MA, Burcin TL, Ley K, Tung KS, Engelhard VH, Macdonald TL, Pearson-White S, Lynch KR. Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720. The Journal of Biological Chemistry. 280: 36865-72. PMID 16093248 DOI: 10.1074/Jbc.M506293200  1
2005 Chordia MD, Zigler M, Murphree LJ, Figler H, Macdonald TL, Olsson RA, Linden J. 6-Aryl-8H-indeno[1,2-d]thiazol-2-ylamines: A1 adenosine receptor agonist allosteric enhancers having improved potency Journal of Medicinal Chemistry. 48: 5131-5139. PMID 16078833 DOI: 10.1021/Jm049132J  1
2005 Clemens JJ, Davis MD, Lynch KR, Macdonald TL. Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: discovery of potent S1P1 receptor agonists. Bioorganic & Medicinal Chemistry Letters. 15: 3568-72. PMID 15982878 DOI: 10.1016/J.Bmcl.2005.05.097  1
2005 McCalmont WF, Patterson JR, Lindenmuth MA, Heady TN, Haverstick DM, Gray LS, Macdonald TL. Investigation into the structure-activity relationship of novel concentration dependent, dual action T-type calcium channel agonists/antagonists. Bioorganic & Medicinal Chemistry. 13: 3821-39. PMID 15863008 DOI: 10.1016/J.Bmc.2005.03.004  1
2005 Bolick DT, Srinivasan S, Kim KW, Hatley ME, Clemens JJ, Whetzel A, Ferger N, Macdonald TL, Davis MD, Tsao PS, Lynch KR, Hedrick CC. Sphingosine-1-phosphate prevents tumor necrosis factor-{alpha}-mediated monocyte adhesion to aortic endothelium in mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 25: 976-81. PMID 15761190 DOI: 10.1161/01.Atv.0000162171.30089.F6  1
2005 Glover DK, Riou LM, Ruiz M, Sullivan GW, Linden J, Rieger JM, Macdonald TL, Watson DD, Beller GA. Reduction of infarct size and postischemic inflammation from ATL-146e, a highly selective adenosine A2A receptor agonist, in reperfused canine myocardium. American Journal of Physiology. Heart and Circulatory Physiology. 288: H1851-8. PMID 15591104 DOI: 10.1152/Ajpheart.00362.2004  1
2005 Davis MD, Clemens JJ, Macdonald TL, Lynch KR. Sphingosine 1-phosphate analogs as receptor antagonists. The Journal of Biological Chemistry. 280: 9833-41. PMID 15590668 DOI: 10.1074/Jbc.M412356200  1
2004 Gray LS, Perez-Reyes E, Gomora JC, Gamorra JC, Haverstick DM, Shattock M, McLatchie L, Harper J, Brooks G, Heady T, Macdonald TL. The role of voltage gated T-type Ca2+ channel isoforms in mediating "capacitative" Ca2+ entry in cancer cells. Cell Calcium. 36: 489-97. PMID 15488598 DOI: 10.1016/J.Ceca.2004.05.001  1
2004 Johnson MA, Macdonald TL. Accelerated CuZn-SOD-mediated oxidation and reduction in the presence of hydrogen peroxide. Biochemical and Biophysical Research Communications. 324: 446-50. PMID 15465039 DOI: 10.1016/J.Bbrc.2004.09.066  1
2004 Clemens JJ, Davis MD, Lynch KR, Macdonald TL. Synthesis of benzimidazole based analogues of sphingosine-1-phosphate: discovery of potent, subtype-selective S1P4 receptor agonists. Bioorganic & Medicinal Chemistry Letters. 14: 4903-6. PMID 15341948 DOI: 10.1016/J.Bmcl.2004.07.030  1
2004 Heasley BH, Jarosz R, Carter KM, Van SJ, Lynch KR, Macdonald TL. A novel series of 2-pyridyl-containing compounds as lysophosphatidic acid receptor antagonists: development of a nonhydrolyzable LPA3 receptor-selective antagonist. Bioorganic & Medicinal Chemistry Letters. 14: 4069-74. PMID 15225728 DOI: 10.1016/J.Bmcl.2004.05.023  1
2004 McCalmont WF, Heady TN, Patterson JR, Lindenmuth MA, Haverstick DM, Gray LS, Macdonald TL. Design, synthesis, and biological evaluation of novel T-Type calcium channel antagonists. Bioorganic & Medicinal Chemistry Letters. 14: 3691-5. PMID 15203145 DOI: 10.1016/J.Bmcl.2004.05.011  1
2004 Santos WL, Heasley BH, Jarosz R, Carter KM, Lynch KR, Macdonald TL. Synthesis and biological evaluation of phosphonic and thiophosphoric acid derivatives of lysophosphatidic acid. Bioorganic & Medicinal Chemistry Letters. 14: 3473-6. PMID 15177455 DOI: 10.1016/J.Bmcl.2004.04.061  1
2004 Heasley BH, Jarosz R, Lynch KR, Macdonald TL. Initial structure-activity relationships of lysophosphatidic acid receptor antagonists: discovery of a high-affinity LPA1/LPA3 receptor antagonist. Bioorganic & Medicinal Chemistry Letters. 14: 2735-40. PMID 15125924 DOI: 10.1016/J.Bmcl.2004.03.076  1
2004 Joshi E, Chordia MD, Macdonald TL, Linden J, Olsson R. Regioselective oxidation of 2-amino-3-aroyl-4,5-dialkylthiophenes by DMSO Bioorganic and Medicinal Chemistry Letters. 14: 929-933. PMID 15012996 DOI: 10.1016/J.Bmcl.2003.12.010  1
2004 Joshi EM, Heasley BH, Chordia MD, Macdonald TL. In Vitro Metabolism of 2-Acetylbenzothiophene: Relevance to Zileuton Hepatotoxicity Chemical Research in Toxicology. 17: 137-143. PMID 14967000 DOI: 10.1021/Tx0341409  1
2004 Deveau AM, Macdonald TL. Practical synthesis of biaryl colchicinoids containing 3′,4′- catechol ether-based A-rings via Suzuki cross-coupling with ligandless palladium in water Tetrahedron Letters. 45: 803-807. DOI: 10.1016/J.Tetlet.2003.11.016  1
2003 Haji-Momenian S, Rieger JM, Macdonald TL, Brown ML. Comparative molecular field analysis and QSAR on substrates binding to cytochrome p450 2D6. Bioorganic & Medicinal Chemistry. 11: 5545-54. PMID 14642599 DOI: 10.1016/S0968-0896(03)00525-X  1
2003 Clemens JJ, Davis MD, Lynch KR, Macdonald TL. Synthesis of para-alkyl aryl amide analogues of sphingosine-1-phosphate: discovery of potent S1P receptor agonists. Bioorganic & Medicinal Chemistry Letters. 13: 3401-4. PMID 14505636 DOI: 10.1016/S0960-894X(03)00812-6  1
2003 Okusa MD, Ye H, Huang L, Sigismund L, Macdonald T, Lynch KR. Selective blockade of lysophosphatidic acid LPA3 receptors reduces murine renal ischemia-reperfusion injury. American Journal of Physiology. Renal Physiology. 285: F565-74. PMID 12770838 DOI: 10.1152/Ajprenal.00023.2003  1
2003 Smith KS, Smith PL, Heady TN, Trugman JM, Harman WD, Macdonald TL. In vitro metabolism of tolcapone to reactive intermediates: relevance to tolcapone liver toxicity. Chemical Research in Toxicology. 16: 123-8. PMID 12588182 DOI: 10.1021/Tx025569N  1
2002 Riou LM, Ruiz M, Rieger JM, Macdonald TL, Watson DD, Linden J, Beller GA, Glover DK. Influence of propranolol, enalaprilat, verapamil, and caffeine on adenosine A2A-receptor-mediated coronary vasodilation Journal of the American College of Cardiology. 40: 1687-1694. PMID 12427424 DOI: 10.1016/S0735-1097(02)02372-0  1
2002 Kapetanovic IM, Torchin CD, Strong JM, Yonekawa WD, Lu C, Li AP, Dieckhaus CM, Santos WL, Macdonald TL, Sofia RD, Kupferberg HJ. Reactivity of atropaldehyde, a felbamate metabolite in human liver tissue in vitro Chemico-Biological Interactions. 142: 119-134. PMID 12399159 DOI: 10.1016/S0009-2797(02)00058-3  1
2002 Dieckhaus CM, Thompson CD, Roller SG, Macdonald TL. Mechanisms of idiosyncratic drug reactions: The case of felbamate Chemico-Biological Interactions. 142: 99-117. PMID 12399158 DOI: 10.1016/S0009-2797(02)00057-1  1
2002 Gozal D, Gaston BM, Lipton AJ, Johnson MA, Macdonald T, Lieberman MW. Physiology: The ventilatory response to hypoxia Nature. 419: 686. PMID 12384687  1
2002 Lynch KR, Macdonald TL. Structure-activity relationships of lysophosphatidic acid analogs. Biochimica Et Biophysica Acta. 1582: 289-94. PMID 12069840 DOI: 10.1016/S1388-1981(02)00183-X  1
2002 Roller SG, Dieckhaus CM, Santos WL, Sofia RD, Macdonald TL. Interaction between human serum albumin and the felbamate metabolites 4-Hydroxy-5-phenyl-[1,3]oxazinan-2-one and 2-phenylpropenal. Chemical Research in Toxicology. 15: 815-24. PMID 12067249 DOI: 10.1021/Tx025509H  0.8
2002 Chordia MD, Murphree LJ, Macdonald TL, Linden J, Olsson RA. 2-Aminothiazoles: A new class of agonist allosteric enhancers of A1 adenosine receptors Bioorganic and Medicinal Chemistry Letters. 12: 1563-1566. PMID 12039562 DOI: 10.1016/S0960-894X(02)00236-6  1
2002 Zhao S, Smith KS, Deveau AM, Dieckhaus CM, Johnson MA, Macdonald TL, Cook JM. Biological activity of the tryprostatins and their diastereomers on human carcinoma cell lines. Journal of Medicinal Chemistry. 45: 1559-62. PMID 11931609 DOI: 10.1021/Jm0155953  1
2002 Murphree LJ, Marshall MA, Rieger JM, MacDonald TL, Linden J. Human A2A adenosine receptors: High-affinity agonist binding to receptor-g protein complexes containing Gβ4 Molecular Pharmacology. 61: 455-462. PMID 11809871 DOI: 10.1124/Mol.61.2.455  1
2002 Roller SG, Dieckhaus CM, Santos WL, Sofia RD, Macdonald TL. Interaction between human serum albumin and the felbamate metabolites 4-hydroxy-5-phenyl-[1,3]oxazinan-2-one and 2-phenylpropenal Chemical Research in Toxicology. 15: 815-824. DOI: 10.1021/tx025509h  1
2001 Barbosa MD, Arthur AS, Louis RH, MacDonald T, Polin RS, Gazak C, Kassell NF. The novel 5-lipoxygenase inhibitor ABT-761 attenuates cerebral vasospasm in a rabbit model of subarachnoid hemorrhage Neurosurgery. 49: 1205-1213. PMID 11846914 DOI: 10.1097/00006123-200111000-00032  1
2001 Heise CE, Santos WL, Schreihofer AM, Heasley BH, Mukhin YV, Macdonald TL, Lynch KR. Activity of 2-substituted lysophosphatidic acid (LPA) analogs at LPA receptors: discovery of a LPA1/LPA3 receptor antagonist. Molecular Pharmacology. 60: 1173-80. PMID 11723223 DOI: 10.1124/Mol.60.6.1173  1
2001 Im DS, Clemens J, Macdonald TL, Lynch KR. Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors. Biochemistry. 40: 14053-60. PMID 11705398 DOI: 10.1021/Bi011606I  1
2001 Lipton AJ, Johnson MA, Macdonald T, Lieberman MW, Gozal D, Gaston B. S-nitrosothiols signal the ventilatory response to hypoxia. Nature. 413: 171-4. PMID 11557982 DOI: 10.1038/35093117  1
2001 Glover DK, Ruiz M, Takehana K, Petruzella FD, Riou LM, Rieger JM, Macdonald TL, Watson DD, Linden J, Beller GA. Pharmacological stress myocardial perfusion imaging with the potent and selective A2A adenosine receptor agonists ATL193 and ATL146e administered by either intravenous infusion or bolus injection Circulation. 104: 1181-1187. PMID 11535577 DOI: 10.1161/Hc3601.093983  1
2001 Johnson MA, Macdonald TL, Mannick JB, Conaway MR, Gaston B. Accelerated s-nitrosothiol breakdown by amyotrophic lateral sclerosis mutant copper,zinc-superoxide dismutase. The Journal of Biological Chemistry. 276: 39872-8. PMID 11518706 DOI: 10.1074/jbc.M102781200  1
2001 Dieckhaus CM, Santos WL, Sofia RD, Macdonald TL. The chemistry, toxicology, and identification in rat and human urine of 4-hydroxy-5-phenyl-1,3-oxazaperhydroin-2-one: A reactive metabolite in felbamate bioactivation Chemical Research in Toxicology. 14: 958-964. PMID 11511169 DOI: 10.1021/Tx000139N  1
2001 Peirce SM, Skalak TC, Rieger JM, Macdonald TL, Linden J. Selective A2A adenosine receptor activation reduces skin pressure ulcer formation and inflammation American Journal of Physiology - Heart and Circulatory Physiology. 281: H67-H74. PMID 11406470 DOI: 10.1152/Ajpheart.2001.281.1.H67  1
2001 Deveau AM, Labroli MA, Dieckhaus CM, Barthen MT, Smith KS, Macdonald TL. The synthesis of amino-acid functionalized beta-carbolines as topoisomerase II inhibitors. Bioorganic & Medicinal Chemistry Letters. 11: 1251-5. PMID 11392530 DOI: 10.1016/S0960-894X(01)00136-6  1
2001 Heady TN, Gomora JC, Macdonald TL, Perez-Reyes E. Molecular pharmacology of T-type Ca2+ channels. Japanese Journal of Pharmacology. 85: 339-50. PMID 11388636 DOI: 10.1254/Jjp.85.339  1
2001 Dieckhaus CM, Roller SG, Santos WL, Sofia RD, Macdonald TL. Role of glutathione S-transferases A1-1, M1-1, and P1-1 in the detoxification of 2-phenylpropenal, a reactive felbamate metabolite Chemical Research in Toxicology. 14: 511-516. PMID 11368548 DOI: 10.1021/Tx000141E  1
2001 McPherson JA, Barringhaus KG, Bishop GG, Sanders JM, Rieger JM, Hesselbacher SE, Gimple LW, Powers ER, Macdonald T, Sullivan G, Linden J, Sarembock IJ. Adenosine A(2A) receptor stimulation reduces inflammation and neointimal growth in a murine carotid ligation model. Arteriosclerosis, Thrombosis, and Vascular Biology. 21: 791-6. PMID 11348876 DOI: 10.1161/01.Atv.21.5.791  1
2001 Lynch KR, Macdonald TL. Structure activity relationships of lysophospholipid mediators. Prostaglandins & Other Lipid Mediators. 64: 33-45. PMID 11324706 DOI: 10.1016/S0090-6980(01)00106-X  1
2001 Sullivan GW, Rieger JM, Scheld WM, Macdonald TL, Linden J. Cyclic AMP-dependent inhibition of human neutrophil oxidative activity by substituted 2-propynylcyclohexyl adenosine A(2A) receptor agonists. British Journal of Pharmacology. 132: 1017-26. PMID 11226132 DOI: 10.1038/Sj.Bjp.0703893  1
2001 Rieger JM, Brown ML, Sullivan GW, Linden J, Macdonald TL. Design, synthesis, and evaluation of novel A2A adenosine receptor agonists Journal of Medicinal Chemistry. 44: 531-539. PMID 11170643 DOI: 10.1021/Jm0003642  1
2001 Hooks SB, Santos WL, Im DS, Heise CE, Macdonald TL, Lynch KR. Lysophosphatidic acid-induced mitogenesis is regulated by lipid phosphate phosphatases and is Edg-receptor independent. The Journal of Biological Chemistry. 276: 4611-21. PMID 11042183 DOI: 10.1074/Jbc.M007782200  1
2000 Okusa MD, Linden J, Huang L, Rieger JM, MacDonald TL, Huynh LP. A(2A) adenosine receptor-mediated inhibition of renal injury and neutrophil adhesion American Journal of Physiology - Renal Physiology. 279: F809-F818. PMID 11053040 DOI: 10.1152/Ajprenal.2000.279.5.F809  1
2000 Fang K, Johns R, Macdonald T, Kinter M, Gaston B. S-nitrosoglutathione breakdown prevents airway smooth muscle relaxation in the guinea pig American Journal of Physiology - Lung Cellular and Molecular Physiology. 279: L716-L721. PMID 11000132 DOI: 10.1152/Ajplung.2000.279.4.L716  1
2000 Miller TA, Ghosh J, Myers CE, Macdonald TL. 5-HETE congeners as modulators of cell proliferation. Bioorganic & Medicinal Chemistry Letters. 10: 1913-6. PMID 10987416 DOI: 10.1016/S0960-894X(00)00370-X  1
2000 Brown ML, Rieger JM, Macdonald TL. Comparative molecular field analysis of colchicine inhibition and tubulin polymerization for combretastatins binding to the colchicine binding site on beta-tubulin. Bioorganic & Medicinal Chemistry. 8: 1433-41. PMID 10896120 DOI: 10.1016/S0968-0896(00)00068-7  1
2000 Dieckhaus CM, Miller TA, Sofia RD, Macdonald TL. A mechanistic approach to understanding species differences in felbamate bioactivation: relevance to drug-induced idiosyncratic reactions. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 28: 814-22. PMID 10859156  1
2000 Santos WL, Rossi JA, Boggs SD, MacDonald TL. The molecular pharmacology of lysophosphatidate signaling. Annals of the New York Academy of Sciences. 905: 232-41. PMID 10818457 DOI: 10.1111/J.1749-6632.2000.Tb06553.X  1
2000 Thompson CD, Miller TA, Barthen MT, Dieckhaus CM, Sofia RD, Macdonald TL. The synthesis, in vitro reactivity, and evidence for formation in humans of 5-phenyl-1,3-oxazinane-2,4-dione, a metabolite of felbamate. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 28: 434-9. PMID 10725312  1
2000 Haverstick DM, Heady TN, Macdonald TL, Gray LS. Inhibition of human prostate cancer proliferation in vitro and in a mouse model by a compound synthesized to block Ca2+ entry. Cancer Research. 60: 1002-8. PMID 10706116  1
2000 Miller TA, Dieckhaus CM, Macdonald TL. A facile, one-pot procedure for the preparation of 2-phenyl-1,3-propanediol monocarbamate, a metabolite of felbamate Organic Process Research and Development. 4: 611-612. DOI: 10.1021/Op990198B  1
1999 Thompson CD, Barthen MT, Hopper DW, Miller TA, Quigg M, Hudspeth C, Montouris G, Marsh L, Perhach JL, Sofia RD, Macdonald TL. Quantification in patient urine samples of felbamate and three metabolites: acid carbamate and two mercapturic acids. Epilepsia. 40: 769-76. PMID 10368077 DOI: 10.1111/J.1528-1157.1999.Tb00777.X  1
1999 Miller TA, Bulman AL, Thompson CD, Macdonald TL. The synthesis and evaluation of temperature sensitive tubulin toxins. Bioorganic & Medicinal Chemistry Letters. 9: 407-12. PMID 10091693 DOI: 10.1016/S0960-894X(98)00747-1  1
1999 Hopper DW, Ragan SP, Hooks SB, Lynch KR, Macdonald TL. Structure--activity relationships of lysophosphatidic acid: conformationally restricted backbone mimetics. Journal of Medicinal Chemistry. 42: 963-70. PMID 10090779 DOI: 10.1021/Jm970809V  1
1998 Miller TA, Vachaspati PR, Labroli MA, Thompson CD, Bulman AL, Macdonald TL. The synthesis and evaluation of benzannelated-azatoxins: the benzazatoxins. Bioorganic & Medicinal Chemistry Letters. 8: 1065-70. PMID 9871709 DOI: 10.1016/S0960-894X(98)00176-0  1
1998 Kapetanovic IM, Torchin CD, Thompson CD, Miller TA, McNeilly PJ, Macdonald TL, Kupferberg HJ, Perhach JL, Sofia RD, Strong JM. Potentially reactive cyclic carbamate metabolite of the antiepileptic drug felbamate produced by human liver tissue in vitro. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 26: 1089-95. PMID 9806951  1
1998 Hooks SB, Ragan SP, Hopper DW, Hönemann CW, Durieux ME, Macdonald TL, Lynch KR. Characterization of a receptor subtype-selective lysophosphatidic acid mimetic. Molecular Pharmacology. 53: 188-94. PMID 9463475 DOI: 10.1124/Mol.53.2.188  1
1997 Miller TA, Bulman AL, Thompson CD, Garst ME, Macdonald TL. Synthesis and structure-activity profiles of A-homoestranes, the estratropones. Journal of Medicinal Chemistry. 40: 3836-41. PMID 9371249 DOI: 10.1021/Jm970323E  1
1997 Madalengoitia JS, Tepe JJ, Werbovetz KA, Lehnert EK, Macdonald TL. Structure-activity relationship for DNA topoisomerase II-induced DNA cleavage by azatoxin analogues. Bioorganic & Medicinal Chemistry. 5: 1807-15. PMID 9354236 DOI: 10.1016/S0968-0896(97)00113-2  1
1997 Cline SD, Macdonald TL, Osheroff N. Azatoxin is a mechanistic hybrid of the topoisomerase II-targeted anticancer drugs etoposide and ellipticine. Biochemistry. 36: 13095-101. PMID 9335572 DOI: 10.1021/Bi971770Z  1
1997 Thompson CD, Vachaspati PR, Kolis SP, Gulden PH, Garst ME, Wiese A, Munk SA, Harman WD, Macdonald TL. A proposed mechanism for p-aminoclonidine allergenicity based on its relative oxidative lability. Chemical Research in Toxicology. 10: 1032-6. PMID 9305586 DOI: 10.1021/tx9700735  1
1997 Thompson CD, Macdonald TL, Garst ME, Wiese A, Munk SA. Mechanisms of adrenergic agonist induced allergy bioactivation and antigen formation. Experimental Eye Research. 64: 767-73. PMID 9245907 DOI: 10.1006/Exer.1996.0267  1
1997 Lynch KR, Hopper DW, Carlisle SJ, Catalano JG, Zhang M, MacDonald TL. Structure/activity relationships in lysophosphatidic acid: the 2-hydroxyl moiety. Molecular Pharmacology. 52: 75-81. PMID 9224815 DOI: 10.1124/Mol.52.1.75  1
1997 Thompson CD, Gulden PH, Macdonald TL. Identification of modified atropaldehyde mercapturic acids in rat and human urine after felbamate administration. Chemical Research in Toxicology. 10: 457-62. PMID 9114984 DOI: 10.1021/Tx960205E  1
1997 Landino LM, Macdonald TL. Inhibition of the GDP/GTP exchange reaction of ras p21 by aluminum ion. Journal of Inorganic Biochemistry. 66: 99-102. PMID 9112760 DOI: 10.1016/S0162-0134(96)00188-2  1
1997 Miller TA, Bulman AL, Thompson CD, Garst ME, Macdonald TL. The synthesis and evaluation of functionalized estratropones: Potent inhibitors of tubulin polymerization Bioorganic and Medicinal Chemistry Letters. 7: 1851-1856. DOI: 10.1016/S0960-894X(97)00327-2  1
1996 Thompson CD, Kinter MT, Macdonald TL. Synthesis and in vitro reactivity of 3-carbamoyl-2-phenylpropionaldehyde and 2-phenylpropenal: putative reactive metabolites of felbamate. Chemical Research in Toxicology. 9: 1225-9. PMID 8951223 DOI: 10.1021/Tx9601566  1
1996 Guengerich FP, Yun CH, Macdonald TL. Evidence for a 1-electron oxidation mechanism in N-dealkylation of N,N-dialkylanilines by cytochrome P450 2B1. Kinetic hydrogen isotope effects, linear free energy relationships, comparisons with horseradish peroxidase, and studies with oxygen surrogates. The Journal of Biological Chemistry. 271: 27321-9. PMID 8910308 DOI: 10.1074/Jbc.271.44.27321  1
1996 Slunt KM, Grace JM, Macdonald TL, Pearson RD. Effect of mitonafide analogs on topoisomerase II of Leishmania chagasi. Antimicrobial Agents and Chemotherapy. 40: 706-9. PMID 8851597 DOI: 10.1128/Aac.40.3.706  1
1996 Grace JM, MacDonald TL, Roberts RJ, Kinter M. Determination of site-specific modifications of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonenal using matrix assisted laser desorption time-of-flight mass spectrometry. Free Radical Research. 25: 23-9. PMID 8814441 DOI: 10.3109/10715769609145653  1
1996 Tepe JJ, Madalengoitia JS, Slunt KM, Werbovetz KW, Spoors PG, Macdonald TL. Inhibition of DNA topoisomerase II by azaelliptitoxins functionalized in the variable substituent domain. Journal of Medicinal Chemistry. 39: 2188-96. PMID 8667362 DOI: 10.1021/jm9508806  1
1996 Hopper DW, Catalano JG, Macdonald TL. Facile synthesis of lysophospholipids containing unsaturated fatty acid chains Tetrahedron Letters. 37: 7871-7874. DOI: 10.1016/0040-4039(96)01802-3  1
1996 Guzi TJ, Macdonald TL. A novel synthesis of piperidin-3-ones via an intramolecular Amadori-type reaction Tetrahedron Letters. 37: 2939-2942. DOI: 10.1016/0040-4039(96)00499-6  1
1995 Guengerich FP, Okazaki O, Seto Y, Macdonald TL. Radical cation intermediates in N-dealkylation reactions. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 25: 689-709. PMID 7483667 DOI: 10.3109/00498259509061886  1
1995 Landino LM, Macdonald TL. 7 The biochemical pharmacology of taxol® and mechanisms of resistance Pharmacochemistry Library. 22: 301-335. DOI: 10.1016/S0165-7208(06)80021-8  1
1994 Grace JM, Kinter MT, Macdonald TL. Atypical metabolism of deprenyl and its enantiomer, (S)-(+)-N,alpha-dimethyl-N-propynylphenethylamine, by cytochrome P450 2D6. Chemical Research in Toxicology. 7: 286-90. PMID 8075358 DOI: 10.1021/Tx00039A003  1
1994 Werbovetz KA, Spoors PG, Pearson RD, Macdonald TL. Cleavable complex formation in Leishmania chagasi treated with anilinoacridines. Molecular and Biochemical Parasitology. 65: 1-10. PMID 7935616 DOI: 10.1016/0166-6851(94)90110-4  1
1994 Gorycki PD, Macdonald TL. The oxidation of tetrasubstituted alkenes by cytochrome P450. Chemical Research in Toxicology. 7: 745-51. PMID 7696528 DOI: 10.1021/Tx00042A006  1
1994 Miller KE, Grace JM, Macdonald TL. The stabilization of DNA topoisomerase II cleavable complex by mitonafide analogs Bioorganic and Medicinal Chemistry Letters. 4: 1643-1648. DOI: 10.1016/S0960-894X(01)80582-5  1
1994 Lehnert EK, Miller KE, Madalengoitia JS, Guzi TJ, MacDonald TL. DNA topoisomerase II inhibition by substituted 1,2,3,4-tetrahydro-β-carboline derivatives Bioorganic and Medicinal Chemistry Letters. 4: 2411-2416. DOI: 10.1016/S0960-894X(01)80400-5  1
1994 Werbovetz KA, Macdonald TL. On the mechanism of arylamine-DNA adduct formation Bioorganic and Medicinal Chemistry Letters. 4: 2323-2326. DOI: 10.1016/0960-894X(94)85033-X  1
1993 Andres CJ, Macdonald TL, Ocain TD, Longhi D. Conformationally defined analogs of prolylamides. trans-prolyl peptidomimetics Journal of Organic Chemistry. 58: 6609-6613. DOI: 10.1021/Jo00076A018  1
1993 Madalengoitia JS, Macdonald TL. Synthesis of tetrahydrofurocarbazolones via intramolecular Diels-Alder reactions Tetrahedron Letters. 34: 6237-6240. DOI: 10.1016/S0040-4039(00)73719-1  1
1992 Werbovetz KA, Lehnert EK, Macdonald TL, Pearson RD. Cytotoxicity of acridine compounds for Leishmania promastigotes in vitro. Antimicrobial Agents and Chemotherapy. 36: 495-7. PMID 1318684 DOI: 10.1128/Aac.36.2.495  1
1992 Werbovetz KA, Jeronimo SMB, MacDonald TL, Pearson RD. Treatment of leishmaniasis and trypanosomiasis Current Opinion in Infectious Diseases. 5: 840-848. DOI: 10.1097/00001432-199212000-00015  1
1991 Guengerich FP, Shimada T, Bondon A, Macdonald TL. Cytochrome P-450 oxidations and the generation of biologically reactive intermediates. Advances in Experimental Medicine and Biology. 283: 1-11. PMID 2068975 DOI: 10.1007/978-1-4684-5877-0_1  1
1991 Alexander JE, Hunt DF, Lee MK, Shabanowitz J, Michel H, Berlin SC, MacDonald TL, Sundberg RJ, Rebhun LI, Frankfurter A. Characterization of posttranslational modifications in neuron-specific class III beta-tubulin by mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America. 88: 4685-9. PMID 2052551 DOI: 10.1073/Pnas.88.11.4685  1
1991 Huber SK, Werbovetz KA, Obaza-Nutaitis J, Lehnert EK, Macdonald TL. Tubulin binding of conformationally restricted bis-aryl compounds Bioorganic and Medicinal Chemistry Letters. 1: 243-246. DOI: 10.1016/S0960-894X(01)81034-9  1
1990 Hastie SB, Macdonald TL. Binding of colchiceine to tubulin. Mechanisms of ligand association with tubulin. Biochemical Pharmacology. 39: 1271-6. PMID 2322310 DOI: 10.1016/0006-2952(90)90002-3  1
1990 Guengerich FP, MacDonald TL. Mechanisms of cytochrome P-450 catalysis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 4: 2453-9. PMID 2185971  1
1989 Bondon A, Macdonald TL, Harris TM, Guengerich FP. Oxidation of cycloalkylamines by cytochrome P-450. Mechanism-based inactivation, adduct formation, ring expansion, and nitrone formation. The Journal of Biological Chemistry. 264: 1988-97. PMID 2914890  1
1989 Hastie SB, Williams RC, Puett D, Macdonald TL. The binding of isocolchicine to tubulin. Mechanisms of ligand association with tubulin. The Journal of Biological Chemistry. 264: 6682-8. PMID 2708333  1
1989 Latham MD, King CK, Gorycki P, Macdonald TL, Ross WE. Inhibition of topoisomerases by fredericamycin A. Cancer Chemotherapy and Pharmacology. 24: 167-71. PMID 2544307 DOI: 10.1007/BF00300237  1
1989 Hubbard CM, Redpath GT, Macdonald TL, VandenBerg SR. Modulatory effects of aluminum, calcium, lithium, magnesium, and zinc ions on [3H]MK-801 binding in human cerebral cortex. Brain Research. 486: 170-4. PMID 2541870 DOI: 10.1016/0006-8993(89)91290-0  1
1989 Miller JL, Hubbard CM, Litman BJ, Macdonald TL. Inhibition of transducin activation and guanosine triphosphatase activity by aluminum ion. The Journal of Biological Chemistry. 264: 243-50. PMID 2535840  1
1989 Macdonald TL, Gutheim WG, Martin RB, Guengerich FP. Oxidation of substituted N,N-dimethylanilines by cytochrome P-450: estimation of the effective oxidation-reduction potential of cytochrome P-450. Biochemistry. 28: 2071-7. PMID 2497774 DOI: 10.1021/bi00431a016  1
1989 Lehnert EK, Scott Sawyer J, Macdonald TL. Ortho-methylation of phenols with ethyl(iodomethyl)zinc Tetrahedron Letters. 30: 5215-5218. DOI: 10.1016/S0040-4039(01)93745-1  1
1989 Macdonald TL, Delahunty CM, Mead K, O'Dell DE. Carbonyl-initiated cyclization of tetraalkylstannanes Tetrahedron Letters. 30: 1473-1476. DOI: 10.1016/S0040-4039(00)99494-2  1
1988 Humphreys WG, Macdonald TL. The effects on tubulin polymerization and associated guanosine triphosphate hydrolysis of aluminum ion, fluoride and fluoroaluminate species. Biochemical and Biophysical Research Communications. 151: 1025-32. PMID 3128287 DOI: 10.1016/S0006-291X(88)80468-6  1
1988 Macdonald TL, Martin RB. Aluminum ion in biological systems. Trends in Biochemical Sciences. 13: 15-9. PMID 3072691 DOI: 10.1016/0968-0004(88)90012-6  1
1988 Goswami A, Macdonald TL, Hubbard C, Duffel MW, Rosazza JP. Leurosine biotransformations: an unusual ring-fission reaction catalyzed by peroxidase. Chemical Research in Toxicology. 1: 238-42. PMID 2979738 DOI: 10.1021/Tx00004A009  1
1988 Chow KC, Macdonald TL, Ross WE. DNA binding by epipodophyllotoxins and N-acyl anthracyclines: implications for mechanism of topoisomerase II inhibition. Molecular Pharmacology. 34: 467-73. PMID 2845248  1
1988 Sawyer JS, Macdonald TL. Total Synthesis of (±)-N-Acetylcolchinol Tetrahedron Letters. 29: 4839-4842. DOI: 10.1016/S0040-4039(00)80622-X  1
1988 O'Dell DE, Loper JT, Macdonald TL. β-Scission of 8-hydrindanoxyl and related free radicals Journal of Organic Chemistry. 53: 5225-5229.  1
1988 Sawyer JS, Kucerovy A, Macdonald TL, McGarvey GJ. Physical properties and synthetic utility of α-alkoxyorganolithium species as studied through ligand selectivity in tin-lithium exchange Journal of the American Chemical Society. 110: 842-853.  1
1987 Macdonald TL, Humphreys WG, Martin RB. Promotion of tubulin assembly by aluminum ion in vitro. Science (New York, N.Y.). 236: 183-6. PMID 3105058  1
1987 Macdonald TL, Delahunty CM, Sawyer JS. Synthetic studies of periplanone a, a sex pheromone of Periplaneta americana Heterocycles. 25: 305-313.  1
1986 Macdonald TL, Natalie KJ, Prasad G, Sawyer JS. Chemically modified potassium hydride. Significant improvement in yields in some oxy-cope rearrangements Journal of Organic Chemistry. 51: 1124-1126. DOI: 10.1002/Chin.198636109  1
1985 Macdonald TL, Narasimhan N. Nucleophilic substitution of alkyliodines via oxidative ligand transfer Journal of Organic Chemistry. 50: 5000-5001. DOI: 10.1021/Jo00224A080  1
1985 Burka LT, Guengerich FP, Willard RJ, Macdonald TL. Mechanism of cytochrome P-450 catalysis. Mechanism of N-dealkylation and amine oxide deoxygenation Journal of the American Chemical Society. 107: 2549-2551. DOI: 10.1021/Ja00294A057  1
1985 Mead K, Macdonald TL. Metal ion controlled addition to α,β-dialkoxy carbonyl compounds Journal of Organic Chemistry. 50: 422-424.  1
1984 Bane S, Puett D, Macdonald TL, Williams RC. Binding to tubulin of the colchicine analog 2-methoxy-5-(2', 3', 4'-trimethoxyphenyl)tropone. Thermodynamic and kinetic aspects. The Journal of Biological Chemistry. 259: 7391-8. PMID 6736010  1
1984 Kilkuskie RE, Macdonald TL, Hecht SM. Bleomycin may be activated for DNA cleavage by NADPH-cytochrome P-450 reductase. Biochemistry. 23: 6165-71. PMID 6084519 DOI: 10.1021/Bi00320A042  1
1984 Guengerich FP, Macdonald TL. Chemical mechanisms of catalysis by cytochromes P-450: A unified view Accounts of Chemical Research. 17: 9-16. DOI: 10.1021/Ar00097A002  1
1984 Guengerich FP, Willard RJ, Shea JP, Richards LE, Macdonald TL. Mechanism-based inactivation of cytochrome P-450 by heteroatom-substituted cyclopropanes and formation of ring-opened products Journal of the American Chemical Society. 106: 6446-6447. DOI: 10.1002/Chin.198506108  1
1984 Sawyer JS, Macdonald TL, McGarvey GJ. Alkoxy stabilization and synthetic utility of tetrahedral carbanions Journal of the American Chemical Society. 106: 3376-3377. DOI: 10.1002/Chin.198436265  1
1984 Shea JP, Willard RJ, Macdonald TL, Guengerich FP. Mechanism-based inactivation of cytochrome P-450 by heteroatom substituted cyclopropanes and formation of ring opened products Federation Proceedings. 43: no. 361.  1
1983 Burka LT, Plucinski TM, Macdonald TL. Mechanisms of hydroxylation by cytochrome P-450: metabolism of monohalobenzenes by phenobarbital-induced microsomes. Proceedings of the National Academy of Sciences of the United States of America. 80: 6680-4. PMID 6579552 DOI: 10.1073/Pnas.80.21.6680  1
1983 Macdonald TL. Chemical mechanisms of halocarbon metabolism. Critical Reviews in Toxicology. 11: 85-120. PMID 6340969 DOI: 10.3109/10408448309089849  1
1983 Guengerich FP, Fu PP, Macdonald TL, Kaminsky LS, Adams SM. Applications of theoretical chemistry in the prediction of metabolism Trends in Pharmacological Sciences. 4: 443-446. DOI: 10.1016/0165-6147(83)90484-4  1
1983 Macdonald TL, Narayanan BA. Pyrrolizidine alkaloid synthesis. (±)-supinidine [1] Journal of Organic Chemistry. 48: 1129-1131.  1
1982 Tachizawa H, MacDonald TL, Neal RA. Rat liver microsomal metabolism of propyl halides. Molecular Pharmacology. 22: 745-51. PMID 7155131  1
1982 Macdonald TL, Burka LT, Wright ST, Guengerich FP. Mechanisms of hydroxylation by cytochrome P-450: exchange of iron-oxygen intermediates with water. Biochemical and Biophysical Research Communications. 104: 620-5. PMID 6803786 DOI: 10.1016/0006-291X(82)90682-9  1
1982 Macdonald TL, Zirvi K, Burka LT, Peyman P, Guengerich FP. Mechanism of cytochrome P-450 inhibition by cyclopropylamines Journal of the American Chemical Society. 104: 2050-2052. DOI: 10.1021/Ja00371A056  1
1981 Spande TF, Daly JW, Hart DJ, Tsai YM, Macdonald TL. The structure of gephyrotoxin (GTX) 223AB. Experientia. 37: 1242-5. PMID 7327222 DOI: 10.1007/BF01948336  1
1981 Detrich HW, Williams RC, Macdonald TL, Wilson L, Puett D. Changes in the circular dichroic spectrum of colchicine associated with its binding to tubulin. Biochemistry. 20: 5999-6005. PMID 7306489 DOI: 10.1021/Bi00524A012  1
1981 Macdonald TL, Mahalingam S, O'Dell DE. Internal reactions of tetraalkylstannanes with carbon-centered electrophiles Journal of the American Chemical Society. 103: 6767-6769. DOI: 10.1021/Ja00412A049  1
1981 Macdonald TL, Mahalingam S. The allylic alcohol function in alkyltin (IV)-mediated carbocyclization. Regiospecific octalin and hydrindene synthesis Tetrahedron Letters. 22: 2077-2080. DOI: 10.1016/S0040-4039(01)93281-2  1
1981 Macdonald TL, O'Dell DE. β-Scission of 9-decalinoxyl and related free radicals Journal of Organic Chemistry. 46: 1501-1503.  1
1981 Macdonald TL, Narayanan BA, O'Dell DE. α-Haloallyllithium species. Coupling with alkyl bromides Journal of Organic Chemistry. 46: 1504-1506.  1
1980 Guengerich FP, Crawford WM, Domoradzki JY, Macdonald TL, Watanabe PG. In vitro activation of 1,2-dichloroethane by microsomal and cytosolic enzymes. Toxicology and Applied Pharmacology. 55: 303-17. PMID 6999663 DOI: 10.1016/0041-008X(80)90092-7  1
1980 Macdonald TL. Indolizidine alkaloid synthesis. Preparation of the pharaoh ant trail pheromone and gephyrotoxin 223 stereoisomers [2] Journal of Organic Chemistry. 45: 193-194. DOI: 10.1021/Jo01289A049  1
1980 Macdonald TL, Mahalingam S. Alkyltin(IV)-mediated carbocyclization [19] Journal of the American Chemical Society. 102: 2113-2115.  1
1980 Macdonald TL, Reagan DR, Brinkmeyer RS. Reaction of propargylic substrates with organocopper species. Synthetic aspects Journal of Organic Chemistry. 45: 4740-4747.  1
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