W Marston Linehan - Publications

Affiliations: 
Urologic Oncology Branch National Cancer Institue-NIH 

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Year Citation  Score
2022 Jikuya R, Murakami K, Nishiyama A, Kato I, Furuya M, Nakabayashi J, Ramilowski JA, Hamanoue H, Maejima K, Fujita M, Mitome T, Ohtake S, Noguchi G, Kawaura S, Odaka H, ... ... Linehan WM, et al. Single-cell transcriptomes underscore genetically distinct tumor characteristics and microenvironment for hereditary kidney cancers. Iscience. 25: 104463. PMID 35874919 DOI: 10.1016/j.isci.2022.104463  0.373
2022 Anari PY, Lay N, Gopal N, Chaurasia A, Samimi S, Harmon S, Firouzabadi FD, Merino MJ, Wakim P, Turkbey E, Jones EC, Ball MW, Turkbey B, Linehan WM, Malayeri AA. An MRI-based radiomics model to predict clear cell renal cell carcinoma growth rate classes in patients with von Hippel-Lindau syndrome. Abdominal Radiology (New York). PMID 35869307 DOI: 10.1007/s00261-022-03610-5  0.313
2022 Pahwa R, Dubhashi J, Singh A, Jailwala P, Lobanov A, Thomas CJ, Ceribelli M, Wilson K, Ricketts CJ, Vocke CD, Wells C, Bottaro DP, Linehan WM, Neckers L, Srinivasan R. Inhibition of HSP 90 is associated with potent anti-tumor activity in Papillary Renal Cell Carcinoma. Journal of Experimental & Clinical Cancer Research : Cr. 41: 208. PMID 35754026 DOI: 10.1186/s13046-022-02416-z  0.616
2022 Vocke CD, Ricketts CJ, Metwalli AR, Pinto PA, Gautam R, Raffeld M, Merino MJ, Ball MW, Linehan WM. Differential VHL mutation patterns in bilateral clear cell RCC distinguishes between independent primary tumors and contralateral metastatic disease. Urology. PMID 35469800 DOI: 10.1016/j.urology.2022.04.003  0.379
2022 Funasaki S, Mehanna S, Ma W, Nishizawa H, Kamikubo Y, Sugiyama H, Ikeda S, Motoshima T, Hasumi H, Linehan WM, Schmidt LS, Ricketts C, Suda T, Oike Y, Kamba T, et al. Targeting chemoresistance in Xp11.2 translocation renal cell carcinoma using a novel polyamide-chlorambucil conjugate. Cancer Science. PMID 35396773 DOI: 10.1111/cas.15364  0.363
2022 Ford JW, Gonzalez-Cotto M, MacFarlane AW, Peri S, Howard OMZ, Subleski JJ, Ruth KJ, Haseebuddin M, Al-Saleem T, Yang Y, Rayman P, Rini B, Linehan WM, Finke J, Weiss JM, et al. Tumor-Infiltrating Myeloid Cells Co-Express TREM1 and TREM2 and Elevated TREM-1 Associates With Disease Progression in Renal Cell Carcinoma. Frontiers in Oncology. 11: 662723. PMID 35223446 DOI: 10.3389/fonc.2021.662723  0.308
2021 Jonasch E, Donskov F, Iliopoulos O, Rathmell WK, Narayan VK, Maughan BL, Oudard S, Else T, Maranchie JK, Welsh SJ, Thamake S, Park EK, Perini RF, Linehan WM, Srinivasan R, et al. Belzutifan for Renal Cell Carcinoma in von Hippel-Lindau Disease. The New England Journal of Medicine. 385: 2036-2046. PMID 34818478 DOI: 10.1056/NEJMoa2103425  0.31
2021 Giubellino A, Ricketts CJ, Moreno V, Linehan WM, Merino MJ. MicroRNA Profiling of Morphologically Heterogeneous Clear Cell Renal Cell Carcinoma. Journal of Cancer. 12: 5375-5384. PMID 34405000 DOI: 10.7150/jca.52310  0.327
2021 Nikpanah M, Xu Z, Jin D, Farhadi F, Saboury B, Ball MW, Gautam R, Merino MJ, Wood BJ, Turkbey B, Jones EC, Linehan WM, Malayeri AA. A deep-learning based artificial intelligence (AI) approach for differentiation of clear cell renal cell carcinoma from oncocytoma on multi-phasic MRI. Clinical Imaging. 77: 291-298. PMID 34171743 DOI: 10.1016/j.clinimag.2021.06.016  0.308
2021 Abreu D, Carvalhal G, Gueglio G, Tobia I, Garcia P, Zuñiga A, Meza L, Bengió R, Scorticati C, Castillejos R, Rodriguez F, Autran AM, Gonzales C, Gadu J, Nolazco A, ... ... Linehan WM, et al. Prognostic Factors in De Novo Metastatic Renal Cell Carcinoma: A Report From the Latin American Renal Cancer Group. Jco Global Oncology. 7: 671-685. PMID 33974442 DOI: 10.1200/GO.20.00621  0.346
2021 Owens-Walton J, Gurram S, Merino MJ, Linehan WM, Ball MW. Macronodular adrenal hyperplasia masquerading as an upper pole renal mass. Urology Case Reports. 37: 101603. PMID 33665124 DOI: 10.1016/j.eucr.2021.101603  0.327
2021 Yang Y, Ricketts CJ, Vocke CD, Killian JK, Padilla-Nash HM, Lang M, Wei D, Lee YH, Wangsa D, Sourbier C, Meltzer PS, Ried T, Merino MJ, Metwalli AR, Ball MW, ... ... Linehan WM, et al. Characterization of genetically defined sporadic and hereditary type 1 papillary renal cell carcinoma cell lines. Genes, Chromosomes & Cancer. PMID 33527590 DOI: 10.1002/gcc.22940  0.31
2020 Merino MJ, Ricketts CJ, Moreno V, Yang Y, Fan TWM, Lane AN, Meltzer PS, Vocke CD, Crooks DR, Linehan WM. Multifocal Renal Cell Carcinomas With Somatic IDH2 Mutation: Report of a Previously Undescribed Neoplasm. The American Journal of Surgical Pathology. PMID 33165095 DOI: 10.1097/PAS.0000000000001611  0.359
2020 Reigle J, Secic D, Biesiada J, Wetzel C, Shamsaei B, Chu J, Zang Y, Zhang X, Talbot NJ, Bischoff ME, Zhang Y, Thakar CV, Gaitonde K, Sidana A, Bui H, ... ... Linehan WM, et al. Tobacco smoking induces metabolic reprogramming of renal cell carcinoma. The Journal of Clinical Investigation. PMID 32970633 DOI: 10.1172/JCI140522  0.326
2020 Perez M, Bak DW, Bergholtz SE, Crooks DR, Arimilli BS, Yang Y, Weerapana E, Linehan WM, Meier JL. Heterogeneous adaptation of cysteine reactivity to a covalent oncometabolite. The Journal of Biological Chemistry. PMID 32820045 DOI: 10.1074/Jbc.Ac120.014993  0.428
2020 Panarsky R, Crooks DR, Lane AN, Yang Y, Cassel TA, Fan TW, Linehan WM, Moscow JA. Fumarate hydratase-deficient renal cell carcinoma cells respond to asparagine by activation of the unfolded protein response and stimulation of the hexosamine biosynthetic pathway. Cancer & Metabolism. 8: 7. PMID 32774853 DOI: 10.1186/S40170-020-00214-9  0.415
2020 Paschall AK, Nikpanah M, Farhadi F, Jones EC, Wakim PG, Dwyer AJ, Gautam R, Merino MJ, Srinivasan R, Linehan WM, Malayeri AA. Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome: Spectrum of imaging findings. Clinical Imaging. 68: 14-19. PMID 32562921 DOI: 10.1016/J.Clinimag.2020.06.010  0.466
2020 Farhadi F, Nikpanah M, Paschall AK, Shafiei A, Tadayoni A, Ball MW, Linehan WM, Jones EC, Malayeri AA. Clear Cell Renal Cell Carcinoma Growth Correlates with Baseline Diffusion-weighted MRI in Von Hippel-Lindau Disease. Radiology. 295: E10. PMID 32421466 DOI: 10.1148/Radiol.2020204010  0.382
2020 Choueiri TK, Atkins MB, Bakouny Z, Carlo MI, Drake CG, Jonasch E, Kapur P, Lewis B, Linehan WM, Mitchell MJ, Pal SK, Pels K, Poteat S, Rathmell WK, Rini BI, et al. Summary from the First Kidney Cancer Research Summit, September 12-13, 2019: A Focus on Translational Research. Journal of the National Cancer Institute. PMID 32359162 DOI: 10.1093/Jnci/Djaa064  0.44
2020 Walter B, Gil S, Naizhen X, Kruhlak MJ, Linehan WM, Srinivasan R, Merino MJ. Determination of the Expression of PD-L1 in the Morphologic Spectrum of Renal Cell Carcinoma. Journal of Cancer. 11: 3596-3603. PMID 32284756 DOI: 10.7150/Jca.35738  0.319
2020 Wei D, Yang Y, Ricketts CJ, Vocke CD, Ball M, Sourbier C, Wangsa D, Wangsa D, Guha R, Zhang X, Wilson K, Chen L, Meltzer PS, Ried T, Thomas CJ, ... ... Linehan WM, et al. Novel renal medullary carcinoma cell lines, UOK353 and UOK360, provide preclinical tools to identify new therapeutic treatments. Genes, Chromosomes & Cancer. PMID 32259323 DOI: 10.1002/Gcc.22847  0.439
2020 Farhadi F, Nikpanah M, Paschall AK, Shafiei A, Tadayoni A, Ball MW, Linehan WM, Jones EC, Malayeri AA. Clear Cell Renal Cell Carcinoma Growth Correlates with Baseline Diffusion-weighted MRI in Von Hippel-Lindau Disease. Radiology. 191016. PMID 32255415 DOI: 10.1148/Radiol.2020191016  0.363
2020 O'Connor LP, Lebastchi AH, Brems J, Wang AZ, Linehan WM, Ball MW. Salvage robotic transmesenteric off-clamp partial nephrectomy after multiple prior open kidney surgeries. Urology Case Reports. 30: 101135. PMID 32140418 DOI: 10.1016/J.Eucr.2020.101135  0.4
2020 Ball MW, An JY, Gomella PT, Gautam R, Ricketts CJ, Vocke CD, Schmidt LS, Merino MJ, Srinivasan R, Malayeri AA, Metwalli AR, Linehan WM. Growth Rates of Genetically Defined Renal Tumors: Implications for Active Surveillance and Intervention. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. JCO1902263. PMID 32083993 DOI: 10.1200/Jco.19.02263  0.411
2020 Oshima N, Ishida R, Kishimoto S, Beebe K, Brender JR, Yamamoto K, Urban D, Rai G, Johnson MS, Benavides G, Squadrito GL, Crooks D, Jackson J, Joshi A, Mott BT, ... ... Linehan WM, et al. Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy. Cell Reports. 30: 1798-1810.e4. PMID 32049011 DOI: 10.1016/J.Celrep.2020.01.039  0.313
2020 Clark DJ, Dhanasekaran SM, Petralia F, Pan J, Song X, Hu Y, da Veiga Leprevost F, Reva B, Lih TM, Chang HY, Ma W, Huang C, Ricketts CJ, Chen L, Krek A, ... ... Linehan WM, et al. Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma. Cell. 180: 207. PMID 31923397 DOI: 10.1016/j.cell.2019.12.026  0.309
2020 Telfer S, Gurram S, Gomella PH, Li W, Bratslavsky G, Metwalli AR, Linehan WM, Ball MW. Surgical learning curve for robotic multiplex partial nephrectomy: The National Cancer Institute Experience. Journal of Clinical Oncology. 38: 660-660. DOI: 10.1200/Jco.2020.38.6_Suppl.660  0.331
2020 Gurram S, Telfer S, Li W, Chalfin H, Linehan WM, Ball MW. Selecting the surgical approach in complex reoperative partial nephrectomies: Does robotics have a role? Journal of Clinical Oncology. 38: 658-658. DOI: 10.1200/Jco.2020.38.6_Suppl.658  0.317
2020 Chalfin H, Yerram N, Gurram S, Linehan WM, Ball MW. A novel multiplex score to predict outcomes of partial nephrectomy for multiple tumors. Journal of Clinical Oncology. 38: 656-656. DOI: 10.1200/Jco.2020.38.6_Suppl.656  0.347
2020 Daneshvar M, Mendhiratta N, Srinivasan R, Jonasch E, Ball MW, Metwali AR, Brugarolas J, Singer EA, Nathanson K, Pierorazio PM, Boris RS, Finelli A, Pal SK, Hakimi AA, Kutikov A, ... ... Linehan WM, et al. Genetic risk assessment for hereditary RCC: Report from the consensus panel meeting. Journal of Clinical Oncology. 38: 615-615. DOI: 10.1200/Jco.2020.38.6_Suppl.615  0.361
2020 Leger PD, Girardi DdM, Al Harthy M, Friend JC, Mac L, Purcell E, Vocke C, Gurram S, Merino MJ, Choyke P, Linehan WM, Srinivasan R. A phase II study of the selective MET kinase inhibitor INC280 in advanced papillary renal cell cancer. Journal of Clinical Oncology. 38: 5075-5075. DOI: 10.1200/Jco.2020.38.15_Suppl.5075  0.397
2020 Jonasch E, Donskov F, Iliopoulos O, Rathmell WK, Narayan V, Maughan BL, Oudard S, Else T, Maranchie JK, Welsh SJ, Thamake S, Park EK, Zojwalla NJ, Perini RF, Linehan WM, et al. Phase II study of the oral HIF-2α inhibitor MK-6482 for Von Hippel-Lindau disease–associated renal cell carcinoma. Journal of Clinical Oncology. 38: 5003-5003. DOI: 10.1200/Jco.2020.38.15_Suppl.5003  0.338
2020 Wedekind MF, Del Rivero J, Arnaldez FI, Srinivasan R, Spencer M, Steinberg SM, Peer CJ, Figg WD, Killian JK, Meltzer PS, Linehan WM, Widemann BC, Glod J. A phase II trial of the DNA methyl transferase inhibitor, SGI-110 (Guadecitabine), in children and adults with SDH-deficient GIST, pheochromocytoma, and paraganglioma, and HLRCC-associated kidney cancer. Journal of Clinical Oncology. 38: 11540-11540. DOI: 10.1200/Jco.2020.38.15_Suppl.11540  0.434
2020 Pahwa R, Dubhashi J, Giri A, Thomas C, Ceribelli M, Jailwala P, Lobanov A, Singh A, Sourbier C, Ricketts CJ, Vocke CD, Yang Y, Linehan WM, Srinivasan R. Abstract 4221: Anti-Tumor activity of the multityrosine kinase inhibitor dasatinib in type 1 papillary renal cell carcinoma Cancer Research. 80: 4221-4221. DOI: 10.1158/1538-7445.Am2020-4221  0.443
2020 Purdue MP, Rhee J, Moore L, Gao X, Sun X, Kirk E, Callahan C, Bencko V, Janout V, Mates D, Foretova L, Szeszenia-Dabrowska N, Matveev V, Zaridze D, Petruzella S, ... ... Linehan WM, et al. Abstract 2340: Differences in risk factors for molecular subtypes of clear cell renal cell carcinoma in a case-control study Epidemiology. 80: 2340-2340. DOI: 10.1158/1538-7445.Am2020-2340  0.412
2020 Gurram* S, Lebastchi AH, Telfer S, Chalfin H, Li W, Gomella PH, Ahdoot M, Yerram N, Linehan WM, Ball MW. PD11-02 TO CLAMP OR NOT TO CLAMP: FOREGOING HILAR CLAMPING DURING PARTIAL NEPHRECTOMY DOES NOT CHANGE RENAL OUTCOMES Journal of Urology. 203. DOI: 10.1097/Ju.0000000000000845.02  0.318
2019 Isono Y, Furuya M, Kuwahara T, Sano D, Suzuki K, Jikuya R, Mitome T, Otake S, Kawahara T, Ito Y, Muraoka K, Nakaigawa N, Kimura Y, Baba M, Nagahama K, ... ... Linehan WM, et al. FLCN alteration drives metabolic reprogramming towards nucleotide synthesis and cyst formation in salivary gland. Biochemical and Biophysical Research Communications. PMID 31806376 DOI: 10.1016/J.Bbrc.2019.11.184  0.358
2019 Sourbier C, Ricketts CJ, Liao PJ, Matsumoto S, Wei D, Lang M, Railkar R, Yang Y, Wei MH, Agarwal P, Krishna M, Mitchell JB, Trepel JB, Neckers L, Linehan WM. Proteasome inhibition disrupts the metabolism of fumarate hydratase- deficient tumors by downregulating p62 and c-Myc. Scientific Reports. 9: 18409. PMID 31804603 DOI: 10.1038/S41598-019-55003-2  0.391
2019 Horiguchi H, Kadomatsu T, Kurahashi R, Hara C, Miyata K, Baba M, Osumi H, Terada K, Araki K, Takai T, Kamba T, Linehan WM, Moroishi T, Oike Y. Dual functions of angiopoietin-like protein 2 signaling in tumor progression and anti-tumor immunity. Genes & Development. 33: 1641-1656. PMID 31727773 DOI: 10.1101/Gad.329417.119  0.364
2019 Gomella PT, Shin P, Srinivasan R, Linehan WM, Ball MW. Obstructive azoospermia secondary to bilateral epididymal cystadenomas in a patient with von Hippel-Lindau. Urology Case Reports. 27: 100922. PMID 31687357 DOI: 10.1016/J.Eucr.2019.100922  0.344
2019 Clark DJ, Dhanasekaran SM, Petralia F, Pan J, Song X, Hu Y, da Veiga Leprevost F, Reva B, Lih TM, Chang HY, Ma W, Huang C, Ricketts CJ, Chen L, Krek A, ... ... Linehan WM, et al. Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma. Cell. 179: 964-983.e31. PMID 31675502 DOI: 10.1016/J.Cell.2019.10.007  0.375
2019 Kishimoto S, Brender JR, Crooks DR, Matsumoto S, Seki T, Oshima N, Merkle H, Lin P, Reed G, Chen AP, Ardenkjaer-Larsen JH, Munasinghe J, Saito K, Yamamoto K, Choyke PL, ... ... Linehan WM, et al. Imaging of glucose metabolism by 13C-MRI distinguishes pancreatic cancer subtypes in mice. Elife. 8. PMID 31408004 DOI: 10.7554/Elife.46312  0.308
2019 Carlo MI, Hakimi AA, Stewart GD, Bratslavsky G, Brugarolas J, Chen YB, Linehan WM, Maher ER, Merino MJ, Offit K, Reuter VE, Shuch B, Coleman JA. Familial Kidney Cancer: Implications of New Syndromes and Molecular Insights. European Urology. PMID 31326218 DOI: 10.1016/J.Eururo.2019.06.015  0.418
2019 Linehan WM, Ricketts CJ. The Cancer Genome Atlas of renal cell carcinoma: findings and clinical implications. Nature Reviews. Urology. PMID 31278395 DOI: 10.1038/S41585-019-0211-5  0.456
2019 Linehan WM, Schmidt LS, Crooks DR, Wei D, Srinivasan R, Lang M, Ricketts CJ. The Metabolic Basis of Kidney Cancer. Cancer Discovery. PMID 31088840 DOI: 10.1158/2159-8290.Cd-18-1354  0.408
2019 Baba M, Furuya M, Motoshima T, Lang M, Funasaki S, Ma W, Sun HW, Hasumi H, Huang Y, Kato I, Kadomatsu T, Satou Y, Morris N, Karim BO, Ileva L, ... ... Linehan WM, et al. TFE3 Xp11.2 translocation renal cell carcinoma mouse model reveals novel therapeutic targets and identifies GPNMB as a diagnostic marker for human disease. Molecular Cancer Research : McR. PMID 31043488 DOI: 10.1158/1541-7786.Mcr-18-1235  0.472
2019 Kurahashi R, Kadomatsu T, Baba M, Hara C, Itoh H, Miyata K, Endo M, Morinaga J, Terada K, Araki K, Eto M, Schmidt LS, Kamba T, Linehan WM, Oike Y. MiR-204-5p: a novel candidate urinary biomarker of Xp11.2 translocation renal cell carcinoma. Cancer Science. PMID 31006167 DOI: 10.1111/Cas.14026  0.383
2019 Gomella PT, Linehan WM, Ball MW. Salvage Surgery After Percutaneous Ablation of Renal Mass in Solitary Kidney in a Patient With Von Hippel-Lindau. Clinical Genitourinary Cancer. 17: e482-e484. PMID 30792008 DOI: 10.1016/J.Clgc.2019.01.011  0.391
2019 Kulkarni RA, Bak DW, Wei D, Bergholtz SE, Briney CA, Shrimp JH, Alpsoy A, Thorpe AL, Bavari AE, Crooks DR, Levy M, Florens L, Washburn MP, Frizzell N, Dykhuizen EC, ... ... Linehan WM, et al. A chemoproteomic portrait of the oncometabolite fumarate. Nature Chemical Biology. PMID 30718813 DOI: 10.1038/S41589-018-0217-Y  0.418
2019 Callahan CL, Moore L, Lenz P, Linehan WM, Nickerson ML, Rothman N, Purdue MP. Differences in Tumor VHL Mutation and Hypoxia-inducible Factor 2α Expression Between African American and White Patients with Clear Cell Renal Cell Carcinoma. European Urology. PMID 30655088 DOI: 10.1016/J.Eururo.2019.01.001  0.436
2019 Jonasch E, Park EK, Thamake S, Hirmand M, Linehan WM, Srinivasan R. An open-label phase II study to evaluate PT2977 for the treatment of von Hippel-Lindau disease-associated renal cell carcinoma. Journal of Clinical Oncology. 37: TPS680-TPS680. DOI: 10.1200/Jco.2019.37.7_Suppl.Tps680  0.427
2019 Bergholtz SE, Briney CA, Kulkarni RA, Wei D, Bak DW, Shrimp JH, Weerapana E, Linehan WM, Meier JL. Abstract 2759: Chemoproteomic profiling of the oncometabolite fumarate Cancer Research. 79: 2759-2759. DOI: 10.1158/1538-7445.Am2019-2759  0.419
2019 Gomella* PT, Telfer S, Lebatschi A, Ahdoot M, Krishnasamy VP, Levy E, Wood B, Linehan WM, Ball MW. MP42-15 TIMING, INCIDENCE AND MANAGEMENT OF DELAYED BLEEDING AFTER PARTIAL NEPHRECTOMY IN PATIENTS AT RISK FOR RECURRENT, BILATERAL, MULTIFOCAL RENAL TUMORS Journal of Urology. 201. DOI: 10.1097/01.Ju.0000556218.19668.74  0.398
2018 Wu J, Wang H, Ricketts CJ, Yang Y, Merino MJ, Zhang H, Shi G, Gan H, Linehan WM, Zhu Y, Ye D. Germline mutations of renal cancer predisposition genes and clinical relevance in Chinese patients with sporadic, early-onset disease. Cancer. PMID 30548481 DOI: 10.1002/Cncr.31908  0.431
2018 Vocke CD, Ricketts CJ, Ball MW, Schmidt LS, Metwalli AR, Middelton LA, Killian JK, Khan J, Meltzer PS, Simonds WF, Merino MJ, Linehan WM. CDC73 germline mutation in a family with mixed epithelial and stromal tumors. Urology. PMID 30452964 DOI: 10.1016/J.Urology.2018.11.013  0.349
2018 Crooks DR, Linehan WM. The Warburg effect in hominis: isotope-resolved metabolism in ccRCC. Nature Reviews. Urology. PMID 30374112 DOI: 10.1038/S41585-018-0110-1  0.356
2018 Rathmell WK, Rathmell JC, Linehan WM. Metabolic Pathways in Kidney Cancer: Current Therapies and Future Directions. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. JCO2018792309. PMID 30372395 DOI: 10.1200/Jco.2018.79.2309  0.409
2018 Kulkarni RA, Briney CA, Crooks DR, Bergholtz SE, Mushti C, Lane AN, Fan T, Lockett SJ, Swenson RE, Linehan WM, Meier JL. Photoinducible Oncometabolite Detection. Chembiochem : a European Journal of Chemical Biology. PMID 30358041 DOI: 10.1002/Cbic.201800651  0.311
2018 Neel BG, Xu Y, Taylor P, Andrade J, Ueberheide B, Shuch B, Glazer PM, Bindra RS, Moran MF, Linehan WM. Pathological Oxidation of PTPN12 Underlies ABL1 Phosphorylation in Hereditary Leiomyomatosis and Renal Cell Carcinoma. Cancer Research. PMID 30297534 DOI: 10.1158/0008-5472.Can-18-0901  0.389
2018 Msaouel P, Hong AL, Mullen EA, Atkins MB, Walker CL, Lee CH, Carden MA, Genovese G, Linehan WM, Rao P, Merino MJ, Grodman H, Dome JS, Fernandez CV, Geller JI, et al. Updated Recommendations on the Diagnosis, Management, and Clinical Trial Eligibility Criteria for Patients With Renal Medullary Carcinoma. Clinical Genitourinary Cancer. PMID 30287223 DOI: 10.1016/J.Clgc.2018.09.005  0.635
2018 Damayanti NP, Budka JA, Khella HWZ, Ferris MW, Ku SY, Kauffman EC, Wood AC, Ahmed K, Chintala VN, Adelaiye-Ogala R, Elbanna M, Orillion AR, Chintala S, Kao C, Linehan WM, et al. Therapeutic targeting of TFE3/IRS-1/PI3K/mTOR axis in translocation renal cell carcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30061365 DOI: 10.1158/1078-0432.Ccr-18-0269  0.476
2018 Ricketts CJ, De Cubas AA, Fan H, Smith CC, Lang M, Reznik E, Bowlby R, Gibb EA, Akbani R, Beroukhim R, Bottaro DP, Choueiri TK, Gibbs RA, Godwin AK, Haake S, ... ... Linehan WM, et al. The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma. Cell Reports. 23: 3698. PMID 29925010 DOI: 10.1016/J.Celrep.2018.06.032  0.539
2018 Ricketts CJ, Linehan WM. The origin, evolution and route to metastasis of clear cell RCC. Nature Reviews. Nephrology. PMID 29875480 DOI: 10.1038/S41581-018-0031-5  0.457
2018 Hasumi H, Furuya M, Tatsuno K, Yamamoto S, Baba M, Hasumi Y, Isono Y, Suzuki K, Jikuya R, Otake S, Muraoka K, Osaka K, Hayashi N, Makiyama K, Miyoshi Y, ... ... Linehan WM, et al. BHD-associated kidney cancer exhibits unique molecular characteristics and a wide variety of variants in chromatin remodeling genes. Human Molecular Genetics. PMID 29767721 DOI: 10.1093/Hmg/Ddy181  0.434
2018 Greer YE, Porat-Shliom N, Nagashima K, Stuelten C, Crooks D, Koparde VN, Gilbert SF, Islam C, Ubaldini A, Ji Y, Gattinoni L, Soheilian F, Wang X, Hafner M, Shetty J, ... ... Linehan WM, et al. ONC201 kills breast cancer cells by targeting mitochondria. Oncotarget. 9: 18454-18479. PMID 29719618 DOI: 10.18632/Oncotarget.24862  0.321
2018 Ricketts CJ, Linehan WM. Multi-regional Sequencing Elucidates the Evolution of Clear Cell Renal Cell Carcinoma. Cell. 173: 540-542. PMID 29677504 DOI: 10.1016/J.Cell.2018.03.077  0.443
2018 Ricketts CJ, De Cubas AA, Fan H, Smith CC, Lang M, Reznik E, Bowlby R, Gibb EA, Akbani R, Beroukhim R, Bottaro DP, Choueiri TK, Gibbs RA, Godwin AK, Haake S, ... ... Linehan WM, et al. The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma. Cell Reports. 23: 313-326.e5. PMID 29617669 DOI: 10.1016/J.Celrep.2018.03.075  0.647
2018 Farhadi F, Nikpanah M, Li X, Symons R, Pourmorteza A, Merino MJ, Linehan WM, Malayeri AA. Germline VHL gene variant in patients with von Hippel-Lindau disease does not predict renal tumor growth. Abdominal Radiology (New York). PMID 29525880 DOI: 10.1007/S00261-018-1540-1  0.418
2018 Paschall AK, Mirmomen SM, Symons R, Pourmorteza A, Gautam R, Sahai A, Dwyer AJ, Merino MJ, Metwalli AR, Linehan WM, Malayeri AA. Differentiating papillary type I RCC from clear cell RCC and oncocytoma: application of whole-lesion volumetric ADC measurement. Abdominal Radiology (New York). PMID 29520425 DOI: 10.1007/S00261-017-1453-4  0.357
2018 Schmidt LS, Linehan WM. FLCN: The causative gene for Birt-Hogg-Dubé syndrome. Gene. 640: 28-42. PMID 28970150 DOI: 10.1016/J.Gene.2017.09.044  0.376
2018 Callahan CL, Moore LE, Lenz P, Schwartz K, Ruterbusch J, Davis F, Chow W, Linehan WM, Merino MJ, Hewitt SM, Rothman N, Hofmann JN, Nickerson ML, Purdue MP. Abstract 4237: Differences in the frequencies of tumorVHLmutation and HIF-2α expression between black and white patients with clear cell renal carcinoma Epidemiology. DOI: 10.1158/1538-7445.Am2018-4237  0.388
2018 Pahwa R, Giri A, Sourbier C, Thomas C, Linehan WM, Neckers L, Srinivasan R. Abstract 3842: Potent antitumor activity of the HSP90 inhibitor SNX-2112 in type 1 papillary renal cell carcinoma Cancer Research. 78: 3842-3842. DOI: 10.1158/1538-7445.Am2018-3842  0.428
2018 Jikuya R, Furuya M, Baba M, Aburatani H, Metwalli AR, Schmidt LS, Linehan WM, Yao M, Hasumi H. Abstract 1244: BHD-associated kidney cancer exhibits unique molecular characteristics and a wide variety of mutations in chromatin remodeling genes Epidemiology. DOI: 10.1158/1538-7445.Am2018-1244  0.371
2018 Wei D, Yang Y, Ricketts CJ, Vocke CD, Ball MW, Sourbier C, Wangsa D, Wangsa D, Guha R, Zhang X, Meltzer P, Reid T, Thomas CJ, Merino MJ, Linehan WM. Abstract 1169: Novel renal medullary carcinoma cell lines, UOK353 and UOK360, provide preclinical tools to identify new therapeutics Tumor Biology. DOI: 10.1158/1538-7445.Am2018-1169  0.417
2018 Linehan WM. Abstract CN04-03: Targeting the metabolic basis of kidney cancer Molecular Cancer Therapeutics. 17. DOI: 10.1158/1535-7163.Targ-17-Cn04-03  0.521
2018 Greer YE, Gilbert S, Islam C, Ubaldini A, Stuelten C, Porat-Shliom N, Weigert R, Ji Y, Gattinoni L, Soheilian F, Nagashima K, Wang X, Hafner M, Shetty J, Tran B, ... ... Linehan WM, et al. Abstract B023: ONC201 kills breast cancer cells by targeting mitochondria Molecular Cancer Therapeutics. 17. DOI: 10.1158/1535-7163.Targ-17-B023  0.307
2018 Lee MM, Rabe DC, McKee TC, Woldemichael GM, Vasselli JR, McMahon JB, Linehan WM, Bottaro DP. Abstract A127: The identification and development of selective natural product inhibitors of hypoxia inducible factor-2α for the treatment of renal cell carcinoma Molecular Cancer Therapeutics. 17. DOI: 10.1158/1535-7163.Targ-17-A127  0.571
2018 Nikpanah M, Ahlman MA, Civelek AC, Mirmomen SM, Li X, Paschall AK, Srinivasan R, Farhadi F, Linehan WM, Malayeri AA. MP14-02 ROLE OF [18F] FLUORODEOXYGLUCOSE-PET IN DIFFERENTIATING PAPILLARY RENAL CELL CARCINOMA FROM CLEAR CELL RENAL CELL CARCINOMA AND ONCOCYTOMA Journal of Urology. 199. DOI: 10.1016/J.Juro.2018.02.495  0.416
2018 Ball M, An J, Peteron J, Merino M, Srinivasan R, Metwalli A, Linehan WM. PD51-01 MANAGEMENT OF GENETICALLY DEFINED RENAL TUMORS UTILIZING SIZE-BASED RISK STRATIFICATION: LONG-TERM RESULTS Journal of Urology. 199. DOI: 10.1016/J.Juro.2018.02.2341  0.335
2018 Motoshima T, Satou Y, Miyazato P, Hasumi H, Huang Y, Kadomatsu T, Yao M, Nagashima Y, Furuya M, Oike Y, Schmidt LS, Kamba T, Linehan WM, Baba M. Pd46-10 Characterization Of Chimeric Tfe3 Transcription Factors Found In Xp11.2 Translocation Renal Cell Carcinoma The Journal of Urology. 199. DOI: 10.1016/J.Juro.2018.02.2158  0.37
2017 Tirosh A, Lakis ME, Green P, Nockel P, Patel D, Nilubol N, Gara SK, Keutgen XM, Linehan WM, Kebebew E. In-silico VHL Gene Mutation Analysis and Prognosis of Pancreatic Neuroendocrine Tumors in von Hippel-Lindau Disease. The Journal of Clinical Endocrinology and Metabolism. PMID 29294023 DOI: 10.1210/Jc.2017-02434  0.304
2017 Ricketts CJ, Linehan WM. Insights into Epigenetic Remodeling in VHL-Deficient Clear Cell Renal Cell Carcinoma. Cancer Discovery. 7: 1221-1223. PMID 29097620 DOI: 10.1158/2159-8290.Cd-17-0971  0.46
2017 Tirosh A, Sadowski SM, Linehan WM, Libutti SK, Patel D, Nilubol N, Kebebew E. Association of VHL Genotype With Pancreatic Neuroendocrine Tumor Phenotype in Patients With von Hippel-Lindau Disease. Jama Oncology. PMID 29075773 DOI: 10.1001/Jamaoncol.2017.3428  0.311
2017 Yang Y, Vocke CD, Ricketts CJ, Wei D, Padilla-Nash HM, Lang M, Sourbier C, Killian JK, Boyle SL, Worrell R, Meltzer PS, Ried T, Merino MJ, Metwalli AR, Linehan WM. Genomic and metabolic characterization of a chromophobe renal cell carcinoma cell line model (UOK276). Genes, Chromosomes & Cancer. PMID 28736828 DOI: 10.1002/Gcc.22476  0.4
2017 Giles RH, Choueiri TK, Heng DY, Albiges L, Hsieh JJ, Linehan WM, Pal S, Maskens D, Paseman B, Jonasch E, Malouf G, Molina AM, Pickering L, Shuch B, Srinivas S, et al. Recommendations for the Management of Rare Kidney Cancers. European Urology. PMID 28720391 DOI: 10.1016/J.Eururo.2017.06.040  0.449
2017 Schmidt LS, Linehan WM. A mouse model of renal cell carcinoma. Nature Medicine. 23: 802-803. PMID 28697179 DOI: 10.1038/Nm.4366  0.465
2017 DiBianco JM, An JY, Tanakchi S, Stanik Z, McGowan A, Maruf M, Sidana A, Jain AL, Muthigi A, George AK, Bayne C, Linehan WM, Boyle SL, Metwalli AR. Managing Renal Cell Carcinoma Associated Paraneoplastic Syndrome with Nephron-sparing Surgery in a Patient with von Hippel-Lindau. Urology Case Reports. 13: 101-103. PMID 28462169 DOI: 10.1016/J.Eucr.2017.02.015  0.427
2017 Vocke CD, Ricketts CJ, Merino MJ, Srinivasan R, Metwalli AR, Middelton LA, Peterson J, Yang Y, Linehan WM. Comprehensive Genomic and Phenotypic Characterization of Germline FH Deletion in Hereditary Leiomyomatosis and Renal Cell Carcinoma (HLRCC). Genes, Chromosomes & Cancer. PMID 28196407 DOI: 10.1002/Gcc.22452  0.424
2017 Baba M, Huang Y, Motoshima T, Hasumi H, Hasumi Y, Furuya M, Nagashima Y, Yao M, Oike Y, Kamba T, Schmidt LS, Linehan WM. Abstract 3527: Clarification of the molecular mechanism for cancer development in Xp11.2 translocation renal cell carcinoma Cancer Research. 77: 3527-3527. DOI: 10.1158/1538-7445.Am2017-3527  0.453
2017 Wei D, Yang Y, Ricketts CJ, Sourbier C, Schmidt LS, Linehan WM. Abstract 1400: Using tumor spheroids to evaluate the efficacy of EZH2 inhibitors in clear cell renal cell carcinoma (ccRCC) Cancer Research. 77: 1400-1400. DOI: 10.1158/1538-7445.Am2017-1400  0.342
2017 An J, Boyle S, Krishnasamy V, Metwalli A, Linehan WM, Wood B. Mp18-14 Multiple Radiofrequency Ablation Zones On Kidney Function The Journal of Urology. 197. DOI: 10.1016/J.Juro.2017.02.624  0.339
2017 Ball M, Boyle S, Khurana K, Gautam R, Bratslavsky G, Linehan WM, Metwalli A. Pd59-03 Growth Kinetics In Von Hippel-Lindau-Associated Renal Tumors: Defining The Influence Of Germline Mutation Type The Journal of Urology. 197. DOI: 10.1016/J.Juro.2017.02.2631  0.367
2016 Linehan WM, Ricketts CJ. Kidney cancer in 2016: RCC - advances in targeted therapeutics and genomics. Nature Reviews. Urology. PMID 28031562 DOI: 10.1038/Nrurol.2016.260  0.386
2016 Zengeya TT, Garlick JM, Kulkarni RA, Miley M, Roberts AM, Yang Y, Crooks DR, Sourbier C, Linehan WM, Meier JL. Co-opting a Bioorthogonal Reaction for Oncometabolite Detection. Journal of the American Chemical Society. 138: 15813-15816. PMID 27960310 DOI: 10.1021/Jacs.6B09706  0.326
2016 Schmidt LS, Linehan WM. Genetic predisposition to kidney cancer. Seminars in Oncology. 43: 566-574. PMID 27899189 DOI: 10.1053/J.Seminoncol.2016.09.001  0.501
2016 Ricketts CJ, Crooks DR, Linehan WM. Targeting HIF2α in Clear-Cell Renal Cell Carcinoma. Cancer Cell. 30: 515-517. PMID 27728802 DOI: 10.1016/J.Ccell.2016.09.016  0.45
2016 Peri S, Caretti E, Tricarico R, Devarajan K, Cheung M, Sementino E, Menges CW, Nicolas E, Vanderveer LA, Howard S, Conrad P, Crowell JA, Campbell KS, Ross EA, Godwin AK, ... ... Linehan WM, et al. Haploinsufficiency in tumor predisposition syndromes: altered genomic transcription in morphologically normal cells heterozygous for VHL or TSC mutation. Oncotarget. PMID 27682873 DOI: 10.18632/Oncotarget.12192  0.505
2016 Fliedner SM, Shankavaram U, Marzouca G, Elkahloun A, Jochmanova I, Daerr R, Linehan WM, Timmers H, Tischler AS, Papaspyrou K, Brieger J, de Krijger R, Breza J, Eisenhofer G, Zhuang Z, et al. Hypoxia-Inducible Factor 2α Mutation-Related Paragangliomas Classify as Discrete Pseudohypoxic Subcluster. Neoplasia (New York, N.Y.). 18: 567-76. PMID 27659016 DOI: 10.1016/J.Neo.2016.07.008  0.323
2016 Linehan WM, Merino MJ, Ricketts CJ. Papillary Renal-Cell Carcinoma. The New England Journal of Medicine. 374: 1991. PMID 27192682 DOI: 10.1056/NEJMc1601872  0.323
2016 Fei SS, Mitchell AD, Heskett MB, Vocke CD, Ricketts CJ, Peto M, Wang NJ, Sönmez K, Linehan WM, Spellman PT. Patient-specific factors influence somatic variation patterns in von Hippel-Lindau disease renal tumours. Nature Communications. 7: 11588. PMID 27174753 DOI: 10.1038/Ncomms11588  0.381
2016 Sidana A, Walton-Diaz A, Truong H, Siddiqui MM, Miao N, Shih J, Mannes A, Bratslavsky G, Linehan WM, Metwalli AR. Postoperative elevation in creatine kinase and its impact on renal function in patients undergoing complex partial nephrectomy. International Urology and Nephrology. PMID 27093966 DOI: 10.1007/S11255-016-1284-1  0.376
2016 Ricketts CJ, Crooks DR, Sourbier C, Schmidt LS, Srinivasan R, Linehan WM. SnapShot: Renal Cell Carcinoma. Cancer Cell. 29: 610-610.e1. PMID 27070709 DOI: 10.1016/J.Ccell.2016.03.021  0.475
2016 Srivastava AK, Hollingshead MG, Weiner J, Navas T, Evrard YA, Khin SA, Ji JJ, Zhang Y, Borgel S, Pfister TD, Kinders R, Bottaro DP, Linehan WM, Tomaszewski JE, Doroshow JH, et al. Pharmacodynamic Response of the MET/HGF-Receptor to Small Molecule Tyrosine Kinase Inhibitors Examined with Validated, Fit-for-Clinic Immunoassays. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 27001313 DOI: 10.1158/1078-0432.CCR-15-2323  0.479
2016 Cherkasova E, Scrivani C, Doh S, Weisman Q, Takahashi Y, Harashima N, Yokoyama H, Srinivasan R, Linehan WM, Lerman MI, Childs RW. Detection of an Immunogenic HERV-E Envelope with Selective Expression in Clear Cell Kidney Cancer. Cancer Research. PMID 26862115 DOI: 10.1158/0008-5472.Can-15-3139  0.428
2016 Kadakia M, Sidana A, Friend JC, Muthigi A, Krane LS, Hawks G, Ninos M, Linehan WM, Srinivasan R. Impact of pretreatment neutrophil-lymphocyte and platelet –lymphocyte ratio in metastatic papillary renal cell cancer. Journal of Clinical Oncology. 34: e16115-e16115. DOI: 10.1200/Jco.2016.34.15_Suppl.E16115  0.331
2016 Lee C, Wei E, Lee W, Chen Y, Mano R, Hakimi AA, Dong Y, Redzematovic A, Cross JR, Tickoo S, Srinivasan R, Oschwald D, Reuter VE, Dunphy M, Cheng E, ... ... Linehan WM, et al. Genomic and metabolic characterization of succinate dehydrogenase B deficient renal cell carcinoma. Journal of Clinical Oncology. 34. DOI: 10.1200/Jco.2016.34.15_Suppl.E16102  0.418
2016 Yang Y, Vocke CD, Ricketts CJ, Wei D, Padilla-Nash HM, Boyle SL, Worrell R, Ried T, Merino MJ, Linehan WM. Abstract A19: A novel cell line model for chromophobe renal cell carcinoma, UOK276, derived from an aggressive sarcomatoid differentiated tumor Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Metca15-A19  0.451
2016 Scroggins BT, Matsuo M, Munasinghe JP, White AO, Sourbier C, Matsumoto S, Linehan WM, Mitchell JB, Krishna MC, Citrin DE. Abstract LB-184: Hyperpolarized13C-pyruvate magnetic resonance spectroscopic imaging of prostate cancer tumor xenografts Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-Lb-184  0.355
2016 Wei D, Ricketts CJ, Schmidt LS, Yang Y, Vocke CD, Linehan WM. Abstract 4707: Investigating the role of EZH2 as a therapeutic target in clear cell renal cell carcinoma (ccRCC) Cancer Research. 76: 4707-4707. DOI: 10.1158/1538-7445.Am2016-4707  0.333
2016 Malayeri A, Pourmorteza A, Shah N, Gautam R, Yazdi A, Lovell J, Boyle S, Asokan I, Srinivasan R, Metwalli A, Linehan WM. MP19-04 CT-BASED VOLUMETRIC CHARACTERIZATION OF RENAL CLEAR CELL CARCINOMA IN VON HIPPEL-LINDAU (VHL) USING NOVEL HISTOGRAM ANALYSIS. Journal of Urology. 195. DOI: 10.1016/J.Juro.2016.02.2752  0.412
2016 Woodford M, Dunn D, Blanden A, Loh S, Bourboulia D, Schmidt L, Linehan WM, Bratslavsky G, Mollapour M. MP85-13 FNIP CO-CHAPERONES PROTECT THE TUMOR SUPPRESSOR FLCN FROM UBIQUITINATION AND DEGRADATION IN THE PROTEASOME Journal of Urology. 195. DOI: 10.1016/J.Juro.2016.02.2279  0.385
2016 Krane LS, Sidana A, Hammerich K, Peterson J, Su D, Merino M, Srinivasan R, Linehan WM, Metwalli A. MP03-19 THE ROLE OF CONCURRENT LYMPHADENECTOMY WITH PARTIAL NEPHRECTOMY IN HEREDITARY LIEYOMYOMA AND RENAL CELL CANCER PATIENTS: A 25 YEAR EXPERIENCE OF THE UROLOGIC ONCOLOGY BRANCH OF THE NATIONAL CANCER INSTITUTE Journal of Urology. 195. DOI: 10.1016/J.Juro.2016.02.1912  0.434
2016 Lovell J, Dwyer A, Jones E, Shah N, Gautam R, Asokan I, Metwalli A, Srinivasan R, Linehan WM, Malayeri A. PD14-04 SPECTRUM OF RADIOLOGICAL FINDINGS OF HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CANCER (HLRCC). Journal of Urology. 195. DOI: 10.1016/J.Juro.2016.02.1001  0.308
2015 Schmidt LS, Linehan WM. Clinical Features, Genetics and Potential Therapeutic Approaches for Birt-Hogg-Dubé Syndrome. Expert Opinion On Orphan Drugs. 3: 15-29. PMID 26581862 DOI: 10.1517/21678707.2014.987124  0.398
2015 Linehan WM, Spellman PT, Ricketts CJ, Creighton CJ, Fei SS, Davis C, Wheeler DA, Murray BA, Schmidt L, Vocke CD, Peto M, Al Mamun AA, Shinbrot E, Sethi A, Brooks S, et al. Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma. The New England Journal of Medicine. PMID 26536169 DOI: 10.1056/Nejmoa1505917  0.672
2015 Ricketts CJ, Linehan WM. Gender Specific Mutation Incidence and Survival Associations in Clear Cell Renal Cell Carcinoma (CCRCC). Plos One. 10: e0140257. PMID 26484545 DOI: 10.1371/Journal.Pone.0140257  0.418
2015 Lang M, Vocke CD, Merino MJ, Schmidt LS, Linehan WM. Mitochondrial DNA mutations distinguish bilateral multifocal renal oncocytomas from familial Birt-Hogg-Dubé tumors. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. 28: 1458-69. PMID 26428318 DOI: 10.1038/Modpathol.2015.101  0.431
2015 Schmidt LS, Linehan WM. Molecular genetics and clinical features of Birt-Hogg-Dubé syndrome. Nature Reviews. Urology. 12: 558-69. PMID 26334087 DOI: 10.1038/Nrurol.2015.206  0.454
2015 Sourbier C, Scroggins BT, Mannes PZ, Liao PJ, Siems K, Wolf D, Beutler JA, Linehan WM, Neckers L. Tonantzitlolone cytotoxicity toward renal cancer cells is PKCθ- and HSF1-dependent. Oncotarget. 6: 29963-74. PMID 26298773 DOI: 10.18632/Oncotarget.4676  0.382
2015 Hasumi H, Baba M, Hasumi Y, Lang M, Huang Y, Oh HF, Matsuo M, Merino MJ, Yao M, Ito Y, Furuya M, Iribe Y, Kodama T, Southon E, Tessarollo L, ... ... Linehan WM, et al. Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn. Proceedings of the National Academy of Sciences of the United States of America. 112: E1624-31. PMID 25775561 DOI: 10.1073/Pnas.1419502112  0.426
2015 Martucci VL, Lorenzo ZG, Weintraub M, del Rivero J, Ling A, Merino M, Siddiqui M, Shuch B, Vourganti S, Linehan WM, Agarwal PK, Pacak K. Association of urinary bladder paragangliomas with germline mutations in the SDHB and VHL genes. Urologic Oncology. 33: 167.e13-20. PMID 25683602 DOI: 10.1016/J.Urolonc.2014.11.017  0.34
2015 Srinivasan R, Ricketts CJ, Sourbier C, Linehan WM. New strategies in renal cell carcinoma: targeting the genetic and metabolic basis of disease. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 10-7. PMID 25564569 DOI: 10.1158/1078-0432.Ccr-13-2993  0.462
2015 Friend JC, Su D, Thimmapuram R, Peterson J, Hawks G, Ninos M, Linehan WM, Srinivasan R. Malignant ascites as a manifestation of advanced papillary renal cell cancer (pRCC). Journal of Clinical Oncology. 33: 465-465. DOI: 10.1200/Jco.2015.33.7_Suppl.465  0.437
2015 Albiges L, Murray B, Brooks A, Cherniack A, Berger A, Creighton CJ, Ricketts C, Bottaro DP, Srinivasan R, Schmidt LS, Meyerson M, Spellman P, Linehan WM, Choueiri TK. Distinct MET alterations to induce a common phenotype and to define a MET-driven subset of papillary RCC: Results from the Cancer Genome Atlas (TCGA) Kidney Renal Papillary (KIRP) Working Group. Journal of Clinical Oncology. 33: 4521-4521. DOI: 10.1200/Jco.2015.33.15_Suppl.4521  0.638
2015 Kaye DR, Pinto PA, Cecchi F, Reilly J, Semerjian A, Giubellino A, Gupta G, Choyke PL, Linehan WM, Bottaro DP. MP6-17 PREDICTIVE VALUE OF PLASMA SOLUBLE MET PROTEIN CONCENTRATION IN PATIENTS WITH PROSTATE CANCER Journal of Urology. 193. DOI: 10.1016/J.Juro.2015.02.264  0.534
2014 Sourbier C, Ricketts CJ, Matsumoto S, Crooks DR, Liao PJ, Mannes PZ, Yang Y, Wei MH, Srivastava G, Ghosh S, Chen V, Vocke CD, Merino M, Srinivasan R, Krishna MC, ... ... Linehan WM, et al. Targeting ABL1-mediated oxidative stress adaptation in fumarate hydratase-deficient cancer. Cancer Cell. 26: 840-50. PMID 25490448 DOI: 10.1016/J.Ccell.2014.10.005  0.36
2014 McNeil BK, Sorbellini M, Grubb RL, Apolo A, Cecchi F, Athauda G, Cohen B, Giubellino A, Simpson H, Agarwal PK, Coleman J, Getzenberg RH, Netto GJ, Shih J, Linehan WM, et al. Preliminary evaluation of urinary soluble Met as a biomarker for urothelial carcinoma of the bladder. Journal of Translational Medicine. 12: 199. PMID 25335552 DOI: 10.1186/1479-5876-12-199  0.601
2014 Linehan WM, Ricketts CJ. Decade in review-kidney cancer: discoveries, therapies and opportunities. Nature Reviews. Urology. 11: 614-6. PMID 25287783 DOI: 10.1038/Nrurol.2014.262  0.468
2014 Davis CF, Ricketts CJ, Wang M, Yang L, Cherniack AD, Shen H, Buhay C, Kang H, Kim SC, Fahey CC, Hacker KE, Bhanot G, Gordenin DA, Chu A, Gunaratne PH, ... ... Linehan WM, et al. The somatic genomic landscape of chromophobe renal cell carcinoma. Cancer Cell. 26: 319-30. PMID 25155756 DOI: 10.1016/J.Ccr.2014.07.014  0.419
2014 Kauffman EC, Ricketts CJ, Rais-Bahrami S, Yang Y, Merino MJ, Bottaro DP, Srinivasan R, Linehan WM. Molecular genetics and cellular features of TFE3 and TFEB fusion kidney cancers. Nature Reviews. Urology. 11: 465-75. PMID 25048860 DOI: 10.1038/Nrurol.2014.162  0.636
2014 Shuch B, Agochukwu N, Ricketts CJ, Vocke CD, Gautam R, Merino M, Linehan WM, Srinivasan R. Vascular Endothelial Growth Factor Receptor-Targeted Therapy in Succinate Dehydrogenase C Kidney Cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. PMID 25024072 DOI: 10.1200/Jco.2013.51.0214  0.308
2014 Schmidt LS, Linehan WM. Hereditary leiomyomatosis and renal cell carcinoma. International Journal of Nephrology and Renovascular Disease. 7: 253-60. PMID 25018647 DOI: 10.2147/Ijnrd.S42097  0.513
2014 Menko FH, Maher ER, Schmidt LS, Middelton LA, Aittomäki K, Tomlinson I, Richard S, Linehan WM. Hereditary leiomyomatosis and renal cell cancer (HLRCC): renal cancer risk, surveillance and treatment. Familial Cancer. 13: 637-44. PMID 25012257 DOI: 10.1007/S10689-014-9735-2  0.472
2014 Alimchandani M, Lara K, Tsokos M, Linehan WM, Merino MJ. Lymphangitic retroperitoneal carcinomatosis occurring from metastatic sarcomatoid chromophobe renal cell carcinoma. Urology Case Reports. 2: 39-62. PMID 24696789 DOI: 10.1016/j.eucr.2013.12.008  0.327
2014 Shuch B, Ricketts CJ, Metwalli AR, Pacak K, Linehan WM. The genetic basis of pheochromocytoma and paraganglioma: Implications for management Urology. 83: 1225-1232. PMID 24642075 DOI: 10.1016/J.Urology.2014.01.007  0.389
2014 Lonser RR, Butman JA, Huntoon K, Asthagiri AR, Wu T, Bakhtian KD, Chew EY, Zhuang Z, Linehan WM, Oldfield EH. Prospective natural history study of central nervous system hemangioblastomas in von Hippel-Lindau disease. Journal of Neurosurgery. 120: 1055-62. PMID 24579662 DOI: 10.3171/2014.1.Jns131431  0.318
2014 Ricketts CJ, Linehan WM. Intratumoral heterogeneity in kidney cancer Nature Genetics. 46: 214-215. PMID 24569233 DOI: 10.1038/Ng.2904  0.474
2014 Ricketts CJ, Hill VK, Linehan WM. Tumor-specific hypermethylation of epigenetic biomarkers, including SFRP1, predicts for poorer survival in patients from the TCGA kidney renal clear cell carcinoma (KIRC) project Plos One. 9. PMID 24454902 DOI: 10.1371/Journal.Pone.0085621  0.465
2014 Shuch B, Vourganti S, Ricketts CJ, Middleton L, Peterson J, Merino MJ, Metwalli AR, Srinivasan R, Linehan WM. Defining early-onset kidney cancer: implications for germline and somatic mutation testing and clinical management. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 32: 431-7. PMID 24378414 DOI: 10.1200/Jco.2013.50.8192  0.353
2014 Shuch B, Hofmann JN, Merino MJ, Nix JW, Vourganti S, Linehan WM, Schwartz K, Ruterbusch JJ, Colt JS, Purdue MP, Chow WH. Pathologic validation of renal cell carcinoma histology in the Surveillance, Epidemiology, and End Results program. Urologic Oncology. 32: 23.e9-13. PMID 23453468 DOI: 10.1016/J.Urolonc.2012.08.011  0.43
2014 Filson CP, Schwartz K, Colt JS, Ruterbusch J, Linehan WM, Chow WH, Miller DC. Use of nephron-sparing surgery among renal cell carcinoma patients with diabetes and hypertension. Urologic Oncology. 32: 27.e15-21. PMID 23419677 DOI: 10.1016/J.Urolonc.2012.09.014  0.406
2014 Metwalli AR, Turkbey B, McKinney Y, Weaver J, Yaqub-Ogun N, Merino M, Lindenberg ML, Linehan WM, Choyke PL. Results of a phase II trial of novel carbonic anhydrase IX radiotracer 18F-VM4-037 in renal cell carcinoma. Journal of Clinical Oncology. 32: LBA400-LBA400. DOI: 10.1200/Jco.2014.32.4_Suppl.Lba400  0.43
2014 Su D, Okoro C, George A, Linehan WM, Metwalli AR. Bilateral multifocal papillary type I renal cell carcinoma: Clinical characteristics and association with chronic renal insufficiency. Journal of Clinical Oncology. 32: 482-482. DOI: 10.1200/Jco.2014.32.4_Suppl.482  0.477
2014 Shuch B, Stamatakis L, Chen C, Gautam R, Merino M, Choyke PL, Linehan WM, Srinivasan R. Utility of 2-(18F) fluoro-2 deoxy-D-glucose PET/CT in advanced papillary renal cell carcinoma. Journal of Clinical Oncology. 32: 419-419. DOI: 10.1200/Jco.2014.32.4_Suppl.419  0.303
2014 Sourbier C, Scroggins B, Mannes PZ, Beutler JA, Linehan WM, Neckers L. Abstract 3202: Deciphering the targets and mechanism of action of the natural product Tonantzitlolone in clear cell renal cell carcinomas Cancer Research. 74: 3202-3202. DOI: 10.1158/1538-7445.Am2014-3202  0.417
2014 Navas T, Lawrence SL, Butcher D, Dutko LM, Hollingshead MG, Kinders RJ, Parchment RE, Bottaro DP, Linehan WM, Tomaszewski JE, Srivastava AK, Doroshow JH. Abstract 1049: Quantitative immunofluorescence assessment of MET and epithelial to mesenchymal transition (EMT) biomarker modulation by antiangiogenic inhibitors in xenograft tumor tissues Cancer Research. 74: 1049-1049. DOI: 10.1158/1538-7445.Am2014-1049  0.56
2014 Srinivasan R, Su D, Stamatakis L, Siddiqui M, Singer E, Shuch B, Nix J, Friend J, Hawks G, Shih J, Choyke P, Linehan W. 5 Mechanism based targeted therapy for hereditary leiomyomatosis and renal cell cancer (HLRCC) and sporadic papillary renal cell carcinoma: interim results from a phase 2 study of bevacizumab and erlotinib European Journal of Cancer. 50: 8. DOI: 10.1016/S0959-8049(14)70131-5  0.361
2014 Okoro C, Su D, George A, Pinto PA, Linehan WM, Metwalli AR. MP64-05 BILATERAL MULTIFOCAL PAPILLARY TYPE I RENAL CELL CARCINOMA: CLINCAL CHARACTERISTICS AND ASOCIATION WITH CHRONIC RENAL INSUFFICIENCY Journal of Urology. 191. DOI: 10.1016/J.Juro.2014.02.1922  0.475
2014 Su D, George A, Okoro C, Pinto P, Metwalli AR, Linehan WM. PD1-04 CLINICAL CHARACTERIZATION, MANAGEMENT, AND OUTCOME OF ADRENAL PHEOCHROMOCYTOMA IN VON HIPPEL-LINDAU FAMILIES Journal of Urology. 191. DOI: 10.1016/J.Juro.2014.02.123  0.318
2013 Siddiqui M, Vourganti S, Shuch B, Agarwal P, Linehan WM. Paragangliomas of the urinary bladder: Experience at the National Cancer Institute. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 31: 307. PMID 28137109 DOI: 10.1200/Jco.2013.31.6_Suppl.307  0.338
2013 Asher KP, Chen C, Lin K, Bratslavsky G, Linehan WM, Srinivasan R. Clinical evaluation of 2-((18)F) fluoro-2 deoxy-D-glucose PET/ CT in hereditary leiomyomatosis and renal cell carcinoma. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 31: 383. PMID 28136885 DOI: 10.1200/Jco.2013.31.6_Suppl.383  0.359
2013 Linehan WM. Evaluation and screening for hereditary renal cell cancers. Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada. 7: 324-5. PMID 24319510 DOI: 10.5489/cuaj.1685  0.31
2013 Linehan WM. Evaluation and screening for hereditary renal cell cancers. Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada. 7: 324-5. PMID 24319510 DOI: 10.5489/cuaj.1685  0.31
2013 Linehan WM, Srinivasan R. Targeted therapies: treating advanced kidney cancer-miles to go before we sleep. Nature Reviews. Clinical Oncology. 10: 614-5. PMID 24129349 DOI: 10.1038/Nrclinonc.2013.183  0.386
2013 Neckers L, Ricketts CJ, Linehan WM. New insights into von Hippel-Lindau function highlighted by investigation of the trichloroethylene-induced p.P81S hotspot mutation Journal of the National Cancer Institute. 105: 1339-1340. PMID 23990664 DOI: 10.1093/Jnci/Djt240  0.401
2013 Linehan WM, Srinivasan R, Garcia JA. Non-clear cell renal cancer: disease-based management and opportunities for targeted therapeutic approaches. Seminars in Oncology. 40: 511-20. PMID 23972715 DOI: 10.1053/J.Seminoncol.2013.05.009  0.433
2013 Shuch B, Linehan WM, Srinivasan R. Aerobic glycolysis: a novel target in kidney cancer. Expert Review of Anticancer Therapy. 13: 711-9. PMID 23773105 DOI: 10.1586/Era.13.57  0.441
2013 Shuch B, Ricketts CJ, Vocke CD, Komiya T, Middelton LA, Kauffman EC, Merino MJ, Metwalli AR, Dennis P, Linehan WM. Germline PTEN mutation Cowden syndrome: an underappreciated form of hereditary kidney cancer. The Journal of Urology. 190: 1990-8. PMID 23764071 DOI: 10.1016/J.Juro.2013.06.012  0.42
2013 Farley MN, Schmidt LS, Mester JL, Peña-Llopis S, Pavia-Jimenez A, Christie A, Vocke CD, Ricketts CJ, Peterson J, Middelton L, Kinch L, Grishin N, Merino MJ, Metwalli AR, Xing C, ... ... Linehan WM, et al. A novel germline mutation in BAP1 predisposes to familial clear-cell renal cell carcinoma. Molecular Cancer Research : McR. 11: 1061-71. PMID 23709298 DOI: 10.1158/1541-7786.Mcr-13-0111  0.421
2013 Stamatakis L, Metwalli AR, Middelton LA, Linehan WM. Diagnosis and management of BHD-associated kidney cancer. Familial Cancer. 12: 397-402. PMID 23703644 DOI: 10.1007/S10689-013-9657-4  0.464
2013 Chow WH, Linehan WM, Devesa SS. Reply to 'Racial disparity in renal cell carcinoma patient survival according to demographic and clinical characteristics'. Cancer. 119: 3101. PMID 23695994 DOI: 10.1002/cncr.28125  0.305
2013 Chow WH, Linehan WM, Devesa SS. Reply to 'Racial disparity in renal cell carcinoma patient survival according to demographic and clinical characteristics'. Cancer. 119: 3101. PMID 23695994 DOI: 10.1002/cncr.28125  0.305
2013 Nickerson ML, Im KM, Misner KJ, Tan W, Lou H, Gold B, Wells DW, Bravo HC, Fredrikson KM, Harkins TT, Milos P, Zbar B, Linehan WM, Yeager M, Andresson T, et al. Somatic alterations contributing to metastasis of a castration-resistant prostate cancer. Human Mutation. 34: 1231-41. PMID 23636849 DOI: 10.1002/Humu.22346  0.393
2013 Linehan WM, Rouault TA. Molecular pathways: Fumarate hydratase-deficient kidney cancer--targeting the Warburg effect in cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 3345-52. PMID 23633457 DOI: 10.1158/1078-0432.Ccr-13-0304  0.404
2013 Zhong M, Weisman P, Zhu B, Brassesco M, Yang Y, Linehan WM, Merino MJ, Zhang D, Rohan S, Cai D, Yang X. Xp11.2 translocation renal cell carcinoma with PSF-TFE3 rearrangement. Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B. 22: 107-11. PMID 23628822 DOI: 10.1097/Pdm.0B013E318278962E  0.422
2013 Turkbey B, Mani H, Aras O, Ho J, Hoang A, Rastinehad AR, Agarwal H, Shah V, Bernardo M, Pang Y, Daar D, McKinney YL, Linehan WM, Kaushal A, Merino MJ, et al. Prostate cancer: can multiparametric MR imaging help identify patients who are candidates for active surveillance? Radiology. 268: 144-52. PMID 23468576 DOI: 10.1148/Radiol.13121325  0.3
2013 Choueiri TK, Vaishampayan U, Rosenberg JE, Logan TF, Harzstark AL, Bukowski RM, Rini BI, Srinivas S, Stein MN, Adams LM, Ottesen LH, Laubscher KH, Sherman L, McDermott DF, Haas NB, ... ... Linehan WM, et al. Phase II and biomarker study of the dual MET/VEGFR2 inhibitor foretinib in patients with papillary renal cell carcinoma. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 31: 181-6. PMID 23213094 DOI: 10.1200/Jco.2012.43.3383  0.63
2013 Sanz-Ortega J, Vocke C, Stratton P, Linehan WM, Merino MJ. Morphologic and molecular characteristics of uterine leiomyomas in hereditary leiomyomatosis and renal cancer (HLRCC) syndrome. The American Journal of Surgical Pathology. 37: 74-80. PMID 23211287 DOI: 10.1097/PAS.0b013e31825ec16f  0.355
2013 Aung PP, Killian K, Poropatich CO, Linehan WM, Merino MJ. Primary neuroendocrine tumors of the kidney: Morphological and molecular alterations of an uncommon malignancy Human Pathology. 44: 873-880. PMID 23199527 DOI: 10.1016/J.Humpath.2012.08.013  0.394
2013 Purdue MP, Moore LE, Merino MJ, Boffetta P, Colt JS, Schwartz KL, Bencko V, Davis FG, Graubard BI, Janout V, Ruterbusch JJ, Beebe-Dimmer J, Cote ML, Shuch B, Mates D, ... ... Linehan WM, et al. An investigation of risk factors for renal cell carcinoma by histologic subtype in two case-control studies. International Journal of Cancer. Journal International Du Cancer. 132: 2640-7. PMID 23150424 DOI: 10.1002/Ijc.27934  0.333
2013 Chow WH, Shuch B, Linehan WM, Devesa SS. Racial disparity in renal cell carcinoma patient survival according to demographic and clinical characteristics Cancer. 119: 388-394. PMID 23147245 DOI: 10.1002/Cncr.27690  0.362
2013 Liu NW, Sanford T, Srinivasan R, Liu JL, Khurana K, Aprelikova O, Valero V, Bechert C, Worrell R, Pinto PA, Yang Y, Merino M, Linehan WM, Bratslavsky G. Impact of ischemia and procurement conditions on gene expression in renal cell carcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 42-9. PMID 23136194 DOI: 10.1158/1078-0432.Ccr-12-2606  0.434
2013 Sudarshan S, Karam JA, Brugarolas J, Thompson RH, Uzzo R, Rini B, Margulis V, Patard JJ, Escudier B, Linehan WM. Metabolism of kidney cancer: from the lab to clinical practice. European Urology. 63: 244-51. PMID 23063455 DOI: 10.1016/J.Eururo.2012.09.054  0.396
2013 Shuch B, Ricketts CJ, Vocke CD, Valera VA, Chen CC, Gautam R, Gupta GN, Gomez Macias GS, Merino MJ, Bratslavsky G, Linehan WM. Adrenal nodular hyperplasia in hereditary leiomyomatosis and renal cell cancer. The Journal of Urology. 189: 430-5. PMID 22982371 DOI: 10.1016/J.Juro.2012.07.139  0.475
2013 Boris RS, Gupta GN, Benson JS, Linehan WM, Pinto PA, Bratslavsky G. Feasibility and outcomes of laparoscopic renal intervention after prior open ipsilateral retroperitoneal surgery. Journal of Endourology / Endourological Society. 27: 196-201. PMID 22963658 DOI: 10.1089/End.2012.0483  0.392
2013 Linehan WM, Ricketts CJ. The metabolic basis of kidney cancer Seminars in Cancer Biology. 23: 46-55. PMID 22705279 DOI: 10.1016/J.Semcancer.2012.06.002  0.414
2013 Gupta GN, Boris R, Chung P, Linehan WM, Pinto PA, Bratslavsky G. Robot-assisted laparoscopic partial nephrectomy for tumors greater than 4 cm and high nephrometry score: feasibility, renal functional, and oncological outcomes with minimum 1 year follow-up. Urologic Oncology. 31: 51-6. PMID 21292511 DOI: 10.1016/J.Urolonc.2010.10.008  0.366
2013 Ballester LY, Aung PP, Lai J, DiGiovanna JJ, Abdullaev Z, Pack S, Linehan WM, Stern JB, Pinto PA, Lee CR. An unusual presentation of glomeruloid hemangioma in a patient with VHL syndrome: A case report and review of literature Open Journal of Clinical Diagnostics. 3: 63-66. DOI: 10.4236/Ojcd.2013.32012  0.403
2013 Shuch B, Vourganti S, Middleton L, Linehan WM. Defining early-onset kidney cancer: Implications for genetic counseling. Journal of Clinical Oncology. 31: 342-342. DOI: 10.1200/Jco.2013.31.6_Suppl.342  0.344
2013 Stamatakis L, Shuch B, Singer EA, Nix J, Truong H, Friend JC, Fowler S, Bratslavsky G, Metwalli AR, Shih JH, Linehan WM, Srinivasan R. Phase II trial of vandetanib in Von Hippel-Lindau-associated renal cell carcinoma. Journal of Clinical Oncology. 31: 4584-4584. DOI: 10.1200/Jco.2013.31.15_Suppl.4584  0.406
2013 Chan S, Popplewell W, Henrich C, Linehan W, Bottaro D, McMahon J, McKee T, Gustafson K. Isolation and Identification of Natural Products from Artocarpus communis Planta Medica. 79. DOI: 10.1055/S-0033-1348739  0.412
2013 Creighton CJ, Morgan M, Gunaratne PH, Wheeler DA, Gibbs RA, Robertson G, Chu A, Beroukhim R, Cibulskis K, Signoretti S, Vandin F, Wu HT, Raphael BJ, Verhaak RGW, Tamboli P, ... ... Linehan WM, et al. Comprehensivemolecular characterization of clear cell renal cell carcinoma Nature. 499: 43-49. DOI: 10.1038/Nature12222  0.432
2012 Srinivasan R, Bottaro DP, Choueiri TK, Vaishampayan UN, Rosenberg JE, Logan T, Harzstark AL, Rini BI, Srinivas S, Adams LM, Laubscher K, Ottesen LH, McDermott DF, Linehan WM. Correlation of germline MET mutation with response to the dual Met/VEGFR-2 inhibitor foretinib in patients with sporadic and hereditary papillary renal cell carcinoma: Results from a multicenter phase II study (MET111644). Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 30: 372. PMID 27968180 DOI: 10.1200/Jco.2012.30.5_Suppl.372  0.611
2012 Shuch B, Ricketts C, Sourbier C, Tsutsumi S, Zhang XY, Belldegrun AS, Wood CG, Linehan WM, Neckers L. Metabolic evaluation of sporadic papillary kidney cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 30: 377. PMID 27968159 DOI: 10.1200/Jco.2012.30.5_Suppl.377  0.42
2012 Choueiri TK, Vaishampayan UN, Rosenberg JE, Logan T, Harzstark AL, Rini BI, Srinivas S, Adams LM, Sherman LJ, Ottesen LH, McDermott DF, Bottaro DP, Linehan WM, Srinivasan R. A phase II and biomarker study (MET111644) of the dual Met/VEGFR-2 inhibitor foretinib in patients with sporadic and hereditary papillary renal cell carcinoma: Final efficacy, safety, and PD results. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 30: 355. PMID 27967970 DOI: 10.1200/Jco.2012.30.5_Suppl.355  0.603
2012 Sourbier C, Srivastava G, Ghosh MC, Ghosh S, Yang Y, Gupta G, Degraff W, Krishna MC, Mitchell JB, Rouault TA, Linehan WM. Targeting HIF2α translation with Tempol in VHL-deficient clear cell renal cell carcinoma. Oncotarget. 3: 1472-82. PMID 23178531 DOI: 10.18632/Oncotarget.561  0.474
2012 Hasumi H, Baba M, Hasumi Y, Huang Y, Oh H, Hughes RM, Klein ME, Takikita S, Nagashima K, Schmidt LS, Linehan WM. Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN. Journal of the National Cancer Institute. 104: 1750-64. PMID 23150719 DOI: 10.1093/Jnci/Djs418  0.376
2012 Ricketts CJ, Shuch B, Vocke CD, Metwalli AR, Bratslavsky G, Middelton L, Yang Y, Wei MH, Pautler SE, Peterson J, Stolle CA, Zbar B, Merino MJ, Schmidt LS, Pinto PA, ... ... Linehan WM, et al. Succinate dehydrogenase kidney cancer: an aggressive example of the Warburg effect in cancer. The Journal of Urology. 188: 2063-71. PMID 23083876 DOI: 10.1016/J.Juro.2012.08.030  0.417
2012 Singer EA, Vourganti S, Lin KY, Gupta GN, Pinto PA, Rastinehad AR, Linehan WM, Bratslavsky G. Outcomes of patients with surgically treated bilateral renal masses and a minimum of 10 years of followup. The Journal of Urology. 188: 2084-8. PMID 23083858 DOI: 10.1016/J.Juro.2012.08.038  0.367
2012 Teicher BA, Linehan WM, Helman LJ. Targeting cancer metabolism Clinical Cancer Research. 18: 5537-5545. PMID 23071355 DOI: 10.1158/1078-0432.Ccr-12-2587  0.381
2012 Linehan WM. Genetic basis of kidney cancer: Role of genomics for the development of disease-based therapeutics Genome Research. 22: 2089-2100. PMID 23038766 DOI: 10.1101/gr.131110.111  0.331
2012 Agochukwu NQ, Metwalli AR, Kutikov A, Pinto PA, Linehan WM, Bratslavsky G. Economic burden of repeat renal surgery on solitary kidney--do the ends justify the means? A cost analysis. The Journal of Urology. 188: 1695-700. PMID 22998899 DOI: 10.1016/J.Juro.2012.07.029  0.407
2012 Woldemichael GM, Turbyville TJ, Vasselli JR, Linehan WM, McMahon JB. Lack of a functional VHL gene product sensitizes renal cell carcinoma cells to the apoptotic effects of the protein synthesis inhibitor verrucarin A. Neoplasia (New York, N.Y.). 14: 771-7. PMID 22952429 DOI: 10.1593/Neo.12852  0.379
2012 McKee TC, Rabe D, Bokesch HR, Grkovic T, Whitson EL, Diyabalanage T, Van Wyk AW, Marcum SR, Gardella RS, Gustafson KR, Linehan WM, McMahon JB, Bottaro DP. Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges. Journal of Natural Products. 75: 1632-6. PMID 22928967 DOI: 10.1021/Np300211X  0.594
2012 Shuch B, Linehan WM. Kidney cancer: Is incomplete renal ablation linked to tumour progression? Nature Reviews Urology. 9: 547-548. PMID 22926423 DOI: 10.1038/Nrurol.2012.174  0.431
2012 Yang Y, Valera V, Sourbier C, Vocke CD, Wei M, Pike L, Huang Y, Merino MA, Bratslavsky G, Wu M, Ricketts CJ, Linehan WM. A novel fumarate hydratase-deficient HLRCC kidney cancer cell line, UOK268: a model of the Warburg effect in cancer. Cancer Genetics. 205: 377-90. PMID 22867999 DOI: 10.1016/J.Cancergen.2012.05.001  0.443
2012 Baba M, Keller JR, Sun HW, Resch W, Kuchen S, Suh HC, Hasumi H, Hasumi Y, Kieffer-Kwon KR, Gonzalez CG, Hughes RM, Klein ME, Oh HF, Bible P, Southon E, ... ... Linehan WM, et al. The folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dubé syndrome is required for murine B-cell development. Blood. 120: 1254-61. PMID 22709692 DOI: 10.1182/Blood-2012-02-410407  0.377
2012 Shuch B, Vourganti S, Friend JC, Zehngebot LM, Linehan WM, Srinivasan R. Targeting the mTOR pathway in Chromophobe Kidney Cancer. Journal of Cancer. 3: 152-7. PMID 22481981 DOI: 10.7150/Jca.4378  0.451
2012 Zhong M, De Angelo P, Osborne L, Paniz-Mondolfi AE, Geller M, Yang Y, Linehan WM, Merino MJ, Cordon-Cardo C, Cai D. Translocation renal cell carcinomas in adults: a single-institution experience. The American Journal of Surgical Pathology. 36: 654-62. PMID 22446944 DOI: 10.1097/Pas.0B013E31824F24A6  0.392
2012 Linehan WM. The genetic basis of kidney cancer: Implications for management and use of targeted therapeutic approaches European Urology. 61: 896-898. PMID 22386837 DOI: 10.1016/J.Eururo.2012.02.022  0.485
2012 Weisbrod AB, Kitano M, Gesuwan K, Millo C, Herscovitch P, Nilubol N, Linehan WM, Kebebew E. Clinical utility of functional imaging with ¹⁸F-FDOPA in Von Hippel-Lindau syndrome. The Journal of Clinical Endocrinology and Metabolism. 97: E613-7. PMID 22259055 DOI: 10.1210/Jc.2011-2626  0.311
2012 Shuch B, Bratslavsky G, Linehan WM, Srinivasan R. Sarcomatoid renal cell carcinoma: a comprehensive review of the biology and current treatment strategies. The Oncologist. 17: 46-54. PMID 22234634 DOI: 10.1634/Theoncologist.2011-0227  0.492
2012 Shuch B, Bratslavsky G, Shih J, Vourganti S, Finley D, Castor B, Treat E, Linehan WM, Pantuck AJ, Said JW, Belldegrun AS. Impact of pathological tumour characteristics in patients with sarcomatoid renal cell carcinoma. Bju International. 109: 1600-6. PMID 22221668 DOI: 10.1111/J.1464-410X.2011.10785.X  0.457
2012 Mullen AR, Wheaton WW, Jin ES, Chen PH, Sullivan LB, Cheng T, Yang Y, Linehan WM, Chandel NS, DeBerardinis RJ. Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature. 481: 385-8. PMID 22101431 DOI: 10.1038/Nature10642  0.322
2012 Filson CP, Miller DC, Colt JS, Ruterbusch J, Linehan WM, Chow WH, Schwartz K. Surgical approach and the use of lymphadenectomy and adrenalectomy among patients undergoing radical nephrectomy for renal cell carcinoma. Urologic Oncology. 30: 856-63. PMID 21419672 DOI: 10.1016/J.Urolonc.2010.08.024  0.39
2012 Chung PH, Srinivasan R, Linehan WM, Pinto PA, Bratslavsky G. Renal cell carcinoma with metastases to the gallbladder: four cases from the National Cancer Institute (NCI) and review of the literature. Urologic Oncology. 30: 476-81. PMID 21277810 DOI: 10.1016/J.Urolonc.2010.04.010  0.426
2012 Singer EA, Friend JC, Hawks G, Vocke C, Metwalli AR, Pinto PA, Bratslavsky G, Linehan WM, Srinivasan R. A phase II study of bevacizumab and erlotinib in subjects with advanced hereditary leiomyomatosis and renal cell cancer (HLRCC) or sporadic papillary renal cell cancer (RCC). Journal of Clinical Oncology. 30: TPS4680-TPS4680. DOI: 10.1200/Jco.2012.30.15_Suppl.Tps4680  0.427
2012 Purdue MP, Moore L, Merino MJ, Boffetta P, Colt JS, Schwartz KL, Bencko V, Davis FG, Graubard B, Janout V, Ruterbusch JJ, Beebe-Dimmer J, Cote M, Shuch B, Mates D, ... ... Linehan WM, et al. Abstract 5515: An investigation of risk factors for renal cell carcinoma by histologic subtype in two case-control studies Cancer Research. 72: 5515-5515. DOI: 10.1158/1538-7445.Am2012-5515  0.349
2012 Smith AK, Ninos M, Peterson J, Gautam R, Merino M, Zbar B, Schmidt L, Bratslavsky G, Rosner I, Hoang A, Metwalli A, Pinto PA, Srinivasan R, Linehan WM. 585 HEREDITARY PAPILLARY RENAL CELL CARCINOMA: A 20-YEAR EXPERIENCE IN MANAGEMENT OF A UNIQUE HEREDITARY CANCER SYNDROME Journal of Urology. 187. DOI: 10.1016/J.Juro.2012.02.661  0.502
2012 Kauffman E, Gupta G, Cecchi F, Raffensperger K, Linehan WM, Bottaro DP, Srinivasan R. 448 CHARACTERIZATION OF THE AKT-MTOR PATHWAY IN TFE3-FUSION RENAL CELL CANCERS AND IMPLICATIONS FOR TARGETED THERAPY Journal of Urology. 187. DOI: 10.1016/J.Juro.2012.02.515  0.627
2012 Agochukwu N, Khurana K, Kauffman E, Shuch B, Valera V, Yang Y, Linehan WM, Bratslavsky G. 153 CARBONIC ANHYDRASE XII: POTENTIAL ROLE IN LYMPHATIC METASTASES OF RENAL CELL CARCINOMA Journal of Urology. 187. DOI: 10.1016/J.Juro.2012.02.203  0.403
2011 Sorbellini M, Giubellino A, Srivastava G, Sourbier C, Pinto PA, Linehan W, Bottaro DP. Effect of the orally available MET inhibitor PF-2341066 on tumor burden and metastasis in an orthotopic xenograft model of bladder cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 263. PMID 27968590 DOI: 10.1200/Jco.2011.29.7_Suppl.263  0.546
2011 Sorbellini M, Giubellino A, Srivastava G, Sourbier C, Jagoda E, Williams M, Choyke PL, Pinto PA, Linehan W, Bottaro DP. Use of a MET-specific photoprobe to identify bladder tumors in an orthotopic xenograft model of bladder cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 260. PMID 27968576 DOI: 10.1200/Jco.2011.29.7_Suppl.260  0.567
2011 Barrisford GW, Singer EA, Rosner IL, Linehan WM, Bratslavsky G. Familial renal cancer: molecular genetics and surgical management. International Journal of Surgical Oncology. 2011: 658767. PMID 22312516 DOI: 10.1155/2011/658767  0.453
2011 Valera VA, Walter BA, Linehan WM, Merino MJ. Regulatory Effects of microRNA-92 (miR-92) on VHL Gene Expression and the Hypoxic Activation of miR-210 in Clear Cell Renal Cell Carcinoma. Journal of Cancer. 2: 515-26. PMID 22043236 DOI: 10.7150/Jca.2.515  0.322
2011 Moore LE, Nickerson ML, Brennan P, Toro JR, Jaeger E, Rinsky J, Han SS, Zaridze D, Matveev V, Janout V, Kollarova H, Bencko V, Navratilova M, Szeszenia-Dabrowska N, Mates D, ... ... Linehan WM, et al. Von Hippel-Lindau (VHL) inactivation in sporadic clear cell renal cancer: associations with germline VHL polymorphisms and etiologic risk factors. Plos Genetics. 7: e1002312. PMID 22022277 DOI: 10.1371/Journal.Pgen.1002312  0.424
2011 Linguraru MG, Wang S, Shah F, Gautam R, Peterson J, Linehan WM, Summers RM. Automated noninvasive classification of renal cancer on multiphase CT. Medical Physics. 38: 5738-46. PMID 21992388 DOI: 10.1118/1.3633898  0.422
2011 Bratslavsky G, Linehan WM. Surgery: Routine adrenalectomy in renal cancer-an antiquated practice Nature Reviews Urology. 8: 534-536. PMID 21931345 DOI: 10.1038/Nrurol.2011.136  0.387
2011 Tong WH, Sourbier C, Kovtunovych G, Jeong SY, Vira M, Ghosh M, Romero VV, Sougrat R, Vaulont S, Viollet B, Kim YS, Lee S, Trepel J, Srinivasan R, Bratslavsky G, ... ... Linehan WM, et al. The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels. Cancer Cell. 20: 315-27. PMID 21907923 DOI: 10.1016/J.Ccr.2011.07.018  0.35
2011 Bokesch HR, Gardella RS, Rabe DC, Bottaro DP, Linehan WM, McMahon JB, McKee TC. A new hypoxia inducible factor-2 inhibitory pyrrolinone alkaloid from roots and stems of Piper sarmentosum. Chemical & Pharmaceutical Bulletin. 59: 1178-9. PMID 21881266 DOI: 10.1248/Cpb.59.1178  0.432
2011 Sanford T, Chung PH, Reinish A, Valera V, Srinivasan R, Linehan WM, Bratslavsky G. Molecular sub-classification of renal epithelial tumors using meta-analysis of gene expression microarrays. Plos One. 6: e21260. PMID 21818257 DOI: 10.1371/Journal.Pone.0021260  0.405
2011 Shuch B, Linehan WM, Bratslavsky G. Repeat partial nephrectomy: Surgical, functional and oncological outcomes Current Opinion in Urology. 21: 368-375. PMID 21788903 DOI: 10.1097/Mou.0B013E32834964Ea  0.346
2011 Bratslavsky G, Sanford T, Srinivasan R, Aprelikova O, Liu J, Quezado M, Merino M, Linehan WM. Differential genetic expression in large versus small clear cell renal cell carcinoma: results from microarray analysis. Journal of Cancer. 2: 271-9. PMID 21611108 DOI: 10.7150/Jca.2.271  0.401
2011 Boris RS, Benhammou J, Merino M, Pinto PA, Linehan WM, Bratslavsky G. The impact of germline BHD mutation on histological concordance and clinical treatment of patients with bilateral renal masses and known unilateral oncocytoma. The Journal of Urology. 185: 2050-5. PMID 21496834 DOI: 10.1016/J.Juro.2011.02.051  0.413
2011 Brooks S, Linehan WM, Srinivasan R, Kong HH. Successful laser treatment of vandetanib-associated cutaneous pigmentation. Archives of Dermatology. 147: 364-5. PMID 21422355 DOI: 10.1001/Archdermatol.2011.30  0.306
2011 Benhammou JN, Vocke CD, Santani A, Schmidt LS, Baba M, Seyama K, Wu X, Korolevich S, Nathanson KL, Stolle CA, Linehan WM. Identification of intragenic deletions and duplication in the FLCN gene in Birt-Hogg-Dubé syndrome. Genes, Chromosomes & Cancer. 50: 466-77. PMID 21412933 DOI: 10.1002/Gcc.20872  0.302
2011 Grkovic T, Whitson EL, Rabe DC, Gardella RS, Bottaro DP, Linehan WM, McMahon JB, Gustafson KR, McKee TC. Identification and evaluation of soft coral diterpenes as inhibitors of HIF-2α induced gene expression. Bioorganic & Medicinal Chemistry Letters. 21: 2113-5. PMID 21353547 DOI: 10.1016/J.Bmcl.2011.01.127  0.594
2011 Eisenhofer G, Lenders JWM, Timmers H, Mannelli M, Grebe SK, Hofbauer LC, Bornstein SR, Tiebel O, Adams K, Bratslavsky G, Linehan WM, Pacak K. Measurements of plasma methoxytyramine, normetanephrine, and metanephrine as discriminators of different hereditary forms of pheochromocytoma Clinical Chemistry. 57: 411-420. PMID 21262951 DOI: 10.1373/Clinchem.2010.153320  0.323
2011 Singer EA, Bratslavsky G, Middelton L, Srinivasan R, Linehan WM. Impact of genetics on the diagnosis and treatment of renal cancer. Current Urology Reports. 12: 47-55. PMID 21128028 DOI: 10.1007/S11934-010-0156-Y  0.498
2011 Fadahunsi AT, Sanford T, Linehan WM, Pinto PA, Bratslavsky G. Feasibility and outcomes of partial nephrectomy for resection of at least 20 tumors in a single renal unit. The Journal of Urology. 185: 49-53. PMID 21074206 DOI: 10.1016/J.Juro.2010.09.032  0.464
2011 Finley DS, Narula N, Valera VA, Merino MJ, Fruehauf J, Wu ML, Linehan WM, Clayman RV. Immunohistochemical basis for adjuvant anti-angiogenic targeted therapy for renal carcinoid: initial case report. Urologic Oncology. 29: 85-9. PMID 19110452 DOI: 10.1016/J.Urolonc.2008.10.017  0.338
2011 Sourbier C, Ratnayake R, Scroggins B, Lee M, Lee S, Trepel J, Beutler J, Neckers L, Linehan WM. Abstract 959: Targeting renal cell carcinoma with englerin A Cancer Research. 71: 959-959. DOI: 10.1158/1538-7445.Am2011-959  0.446
2011 Gupta GN, Lin KY, Sourbier C, Baba M, Guichard S, Linehan WM, Srinivasan R. Abstract 645: Preclinical efficacy of AZD8055, an ATP-competitive mammalian target of rapamycin (mTOR) kinase inhibitor,in vitroin clear cell renal cell carcinoma (RCC) Cancer Research. 71: 645-645. DOI: 10.1158/1538-7445.Am2011-645  0.399
2011 Lin KY, Gupta GN, Sourbier C, Williams H, Guichard S, Linehan WM, Srinivasan R. Abstract 4493: Preclinical efficacy of AZD8055, an ATP-competitive mammalian target of rapamycin (mTOR) kinase inhibitor, in vitro in urothelial carcinoma of the bladder Cancer Research. 71: 4493-4493. DOI: 10.1158/1538-7445.Am2011-4493  0.365
2011 Williams H, Vora A, Baccala A, Pinto P, Linehan WM, Bratslavsky G. 1268 ONCOLOGIC OUTCOMES OF ENUCLEATIVE SURGERY FOR HIGH GRADE CLEAR CELL RENAL CELL CARCINOMA IN VON HIPPEL LINDAU PATIENTS Journal of Urology. 185. DOI: 10.1016/J.Juro.2011.02.953  0.415
2011 Asher K, Gupta G, Benjamin C, Pinto P, Linehan WM, Bratslavsky G. 1262 ROBOT-ASSISTED LAPAROSCOPIC PARTIAL NEPHRECTOMY FOR HEREDITARY OR MULTIFOCAL KIDNEY CANCER: FEASIBILITY AND PERIOPERATIVE OUTCOMES Journal of Urology. 185. DOI: 10.1016/J.Juro.2011.02.947  0.317
2011 Asher K, Gupta G, Linehan WM, Pinto P, Bratslavsky G. V856 ROBOT-ASSISTED LAPAROSCOPIC PARTIAL ADRENALECTOMY FOR PHEOCHROMOCYTOMA: THE NATIONAL CANCER INSTITUTE TECHNIQUE Journal of Urology. 185. DOI: 10.1016/J.Juro.2011.02.678  0.318
2011 Singer EA, Vourganti S, Lin K, Rastinehad AR, Pinto PA, Gupta GN, Linehan WM, Bratslavsky G. 1860 OUTCOMES OF PATIENTS WITH SURGICALLY TREATED BILATERAL RENAL MASSES AND A MINIMUM OF 10 YEARS OF FOLLOW-UP: THE NCI EXPERIENCE Journal of Urology. 185. DOI: 10.1016/J.Juro.2011.02.1907  0.354
2010 Hong SB, Oh H, Valera VA, Baba M, Schmidt LS, Linehan WM. Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization. Plos One. 5: e15793. PMID 21209915 DOI: 10.1371/Journal.Pone.0015793  0.456
2010 Sourbier C, Valera-Romero V, Giubellino A, Yang Y, Sudarshan S, Neckers L, Linehan WM. Increasing reactive oxygen species as a therapeutic approach to treat hereditary leiomyomatosis and renal cell carcinoma. Cell Cycle (Georgetown, Tex.). 9: 4183-9. PMID 20953139 DOI: 10.4161/Cc.9.20.13458  0.422
2010 Miller DC, Ruterbusch J, Colt JS, Davis FG, Linehan WM, Chow WH, Schwartz K. Contemporary clinical epidemiology of renal cell carcinoma: insight from a population based case-control study. The Journal of Urology. 184: 2254-8. PMID 20952033 DOI: 10.1016/J.Juro.2010.08.018  0.394
2010 Benhammou JN, Boris RS, Pacak K, Pinto PA, Linehan WM, Bratslavsky G. Functional and Oncologic Outcomes of Partial Adrenalectomy for Pheochromocytoma in Patients With von Hippel-Lindau Syndrome After at Least 5 Years of Followup The Journal of Urology. 184: 1855-1859. PMID 20846682 DOI: 10.1016/J.Juro.2010.06.102  0.311
2010 Lane BR, Fergany AF, Linehan WM, Bratslavsky G. Should preservable parenchyma, and not tumor size, be the main determinant of the feasibility of partial nephrectomy? Urology. 76: 608-9. PMID 20832610 DOI: 10.1016/J.Urology.2010.04.041  0.308
2010 Singer EA, Bratslavsky G, Linehan WM, Srinivasan R. Targeted therapies for non-clear renal cell carcinoma Targeted Oncology. 5: 119-129. PMID 20680492 DOI: 10.1007/S11523-010-0148-3  0.459
2010 Hong SB, Oh H, Valera VA, Stull J, Ngo DT, Baba M, Merino MJ, Linehan WM, Schmidt LS. Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-beta signaling. Molecular Cancer. 9: 160. PMID 20573232 DOI: 10.1186/1476-4598-9-160  0.462
2010 Kaye DR, Storey BB, Pacak K, Pinto PA, Linehan WM, Bratslavsky G. Partial adrenalectomy: underused first line therapy for small adrenal tumors. The Journal of Urology. 184: 18-25. PMID 20546805 DOI: 10.1016/J.Juro.2010.03.052  0.304
2010 Gupta GN, Peterson J, Thakore KN, Pinto PA, Linehan WM, Bratslavsky G. Oncological outcomes of partial nephrectomy for multifocal renal cell carcinoma greater than 4 cm. The Journal of Urology. 184: 59-63. PMID 20478582 DOI: 10.1016/J.Juro.2010.03.035  0.484
2010 Linehan WM, Srinivasan R, Schmidt LS. The genetic basis of kidney cancer: a metabolic disease. Nature Reviews. Urology. 7: 277-85. PMID 20448661 DOI: 10.1038/Nrurol.2010.47  0.392
2010 Bratslavsky G, Linehan WM. Long-term management of bilateral, multifocal, recurrent renal carcinoma Nature Reviews Urology. 7: 267-275. PMID 20448660 DOI: 10.1038/Nrurol.2010.44  0.455
2010 Zhong M, De Angelo P, Osborne L, Keane-Tarchichi M, Goldfischer M, Edelmann L, Yang Y, Linehan WM, Merino MJ, Aisner S, Hameed M. Dual-color, break-apart FISH assay on paraffin-embedded tissues as an adjunct to diagnosis of Xp11 translocation renal cell carcinoma and alveolar soft part sarcoma. The American Journal of Surgical Pathology. 34: 757-66. PMID 20421778 DOI: 10.1097/Pas.0B013E3181Dd577E  0.36
2010 Liu NW, Khurana K, Sudarshan S, Pinto PA, Linehan WM, Bratslavsky G. Repeat partial nephrectomy on the solitary kidney: surgical, functional and oncological outcomes. The Journal of Urology. 183: 1719-24. PMID 20299057 DOI: 10.1016/J.Juro.2010.01.010  0.382
2010 Johann DJ, Wei BR, Prieto DA, Chan KC, Ye X, Valera VA, Simpson RM, Rudnick PA, Xiao Z, Issaq HJ, Linehan WM, Stein SE, Veenstra TD, Blonder J. Combined blood/tissue analysis for cancer biomarker discovery: Application to renal cell carcinoma Analytical Chemistry. 82: 1584-1588. PMID 20121140 DOI: 10.1021/Ac902204K  0.383
2010 Rahma OE, Ashtar E, Ibrahim R, Toubaji A, Gause B, Herrin VE, Linehan WM, Steinberg SM, Grollman F, Grimes G, Bernstein SA, Berzofsky JA, Khleif SN. A pilot clinical trial testing mutant von Hippel-Lindau peptide as a novel immune therapy in metastatic renal cell carcinoma. Journal of Translational Medicine. 8: 8. PMID 20109232 DOI: 10.1186/1479-5876-8-8  0.419
2010 Linehan WM, Bratslavsky G, Pinto PA, Schmidt LS, Neckers L, Bottaro DP, Srinivasan R. Molecular diagnosis and therapy of kidney cancer. Annual Review of Medicine. 61: 329-43. PMID 20059341 DOI: 10.1146/Annurev.Med.042808.171650  0.665
2010 Yang Y, Valera VA, Padilla-Nash HM, Sourbier C, Vocke CD, Vira MA, Abu-Asab MS, Bratslavsky G, Tsokos M, Merino MJ, Pinto PA, Srinivasan R, Ried T, Neckers L, Linehan WM. UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer. Cancer Genetics and Cytogenetics. 196: 45-55. PMID 19963135 DOI: 10.1016/J.Cancergencyto.2009.08.018  0.435
2010 Cecchi F, Pajalunga D, McNeil B, Rabe D, Fowler A, Liu Y, Gagnon CR, Kallender H, Shah MA, Getzenberg R, Schoenberg M, Martin A, Srinivasan R, Linehan WM, Byrd RA, et al. Abstract SY23-03: Oncogenic signal transduction via the hepatocyte growth factor/Met receptor kinase pathway Cellular and Molecular Biology. DOI: 10.1158/1538-7445.Am10-Sy23-03  0.5
2010 Pike L, Yang Y, Chen D, Ferrick D, Linehan WM, Wu M. Abstract LB-108: Glutamine addition and glucose addiction - linking metabolic abnormalities to genetic alterations in glioblastoma SF188 and hereditary leiomyomatosis renal carcinoma UOK262 Cancer Research. 70. DOI: 10.1158/1538-7445.Am10-Lb-108  0.331
2010 Rabe DC, McKee T, Woldemichael GM, Vasselli JR, McMahon J, Linehan WM, Bottaro DP. Abstract 773: Identification and characterization of natural product-based inhibitors of hypoxia inducible factor-2 alpha Cancer Research. 70: 773-773. DOI: 10.1158/1538-7445.Am10-773  0.618
2010 Sourbier C, Kim Y, Lee S, Trepel J, Neckers L, Linehan WM. Abstract 5291: Exploring mechanisms underlying invasion in HLRCC: Assessing the contribution of HIF and ROS Cancer Research. 70: 5291-5291. DOI: 10.1158/1538-7445.Am10-5291  0.36
2010 Sanford T, Chung P, Reinish A, Srinivasan R, Pinto P, Linehan WM, Bratslavsky G. 372 MOLECULAR SUB-CLASSIFICATION OF RENAL EPITHELIAL NEOPLASMS Journal of Urology. 183. DOI: 10.1016/J.Juro.2010.02.439  0.386
2010 Valera VA, Yang Y, Walter BA, Merino MJ, Linehan WM. 367 EVALUATION OF THE VEGF-VEGF RECEPTOR AXIS IN HEREDITARY LEIOMYOMATOSIS RENAL CELL CARCINOMA (HLRCC) KIDNEY TUMORS Journal of Urology. 183. DOI: 10.1016/J.Juro.2010.02.434  0.429
2010 Baccala AA, Rastinehad AR, Chung PH, Kruecker J, Xu S, Locklin JK, Gates SP, Shih JH, Glossop ND, Linehan WM, Bratslavsky G, Turkbey BI, Choyke PL, Wood BJ, Pinto PA. 303 INCREASED YIELD OF CANCER DETECTION WITH EMRI/US GUIDED FUSED BIOPSY IN PATIENTS WITH PREVIOUS NEGATIVE BIOPSY Journal of Urology. 183. DOI: 10.1016/J.Juro.2010.02.366  0.312
2010 Bratslavsky G, Sanford T, Aprelikova O, Worrell R, Merino M, Srinivasan R, Linehan WM. 219 DIFFERENTIAL GENETIC EXPRESSION IN LARGE VERSUS SMALL CLEAR CELL RCC TUMORS IN THE SAME PATIENTS: RESULTS FROM MICROARRAY ANALYSIS Journal of Urology. 183. DOI: 10.1016/J.Juro.2010.02.276  0.374
2010 Gupta G, Peterson J, Daryanani K, Pinto P, Linehan WM, Bratslavsky G. 986 ONCOLOGIC OUTCOMES OF PARTIAL NEPHRECTOMY FOR MULTIFOCAL RENAL CELL CARCINOMA WITH LARGEST TUMOR GREATER THAN 4CM Journal of Urology. 183. DOI: 10.1016/J.Juro.2010.02.1955  0.445
2010 Boris R, Sanford T, Pinto P, Linehan WM, Bratslavsky G. V949 OFF-CLAMP ROBOT ASSISTED PARTIAL NEPHRECTOMY FOR MULTIFOCAL RENAL MASSES IN THE HEREDITARY RENAL POPULATION Journal of Urology. 183. DOI: 10.1016/J.Juro.2010.02.1854  0.367
2009 Hasumi Y, Baba M, Ajima R, Hasumi H, Valera VA, Klein ME, Haines DC, Merino MJ, Hong SB, Yamaguchi TP, Schmidt LS, Linehan WM. Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2. Proceedings of the National Academy of Sciences of the United States of America. 106: 18722-7. PMID 19850877 DOI: 10.1073/Pnas.0908853106  0.417
2009 Kowalczyk KJ, Hooper HB, Linehan WM, Pinto PA, Wood BJ, Bratslavsky G. Partial nephrectomy after previous radio frequency ablation: the National Cancer Institute experience. The Journal of Urology. 182: 2158-63. PMID 19758659 DOI: 10.1016/J.Juro.2009.07.064  0.376
2009 Boris R, Proano M, Linehan WM, Pinto PA, Bratslavsky G. Initial Experience With Robot Assisted Partial Nephrectomy for Multiple Renal Masses Journal of Urology. 182: 1280-1286. PMID 19683275 DOI: 10.1016/J.Juro.2009.06.036  0.395
2009 Linehan WM. Genetic basis of bilateral renal cancer: Implications for evaluation and management Journal of Clinical Oncology. 27: 3731-3733. PMID 19597019 DOI: 10.1200/Jco.2009.23.0045  0.47
2009 Giubellino A, Linehan WM, Bottaro DP. Targeting the Met signaling pathway in renal cancer Expert Review of Anticancer Therapy. 9: 785-793. PMID 19496715 DOI: 10.1586/Era.09.43  0.638
2009 Linguraru MG, Yao J, Gautam R, Peterson J, Li Z, Linehan WM, Summers RM. Renal Tumor Quantification and Classification in Contrast-Enhanced Abdominal CT. Pattern Recognition. 42: 1149-1161. PMID 19492069 DOI: 10.1016/J.Patcog.2008.09.018  0.417
2009 Beroukhim R, Brunet JP, Di Napoli A, Mertz KD, Seeley A, Pires MM, Linhart D, Worrell RA, Moch H, Rubin MA, Sellers WR, Meyerson M, Linehan WM, Kaelin WG, Signoretti S. Patterns of gene expression and copy-number alterations in von-hippel lindau disease-associated and sporadic clear cell carcinoma of the kidney. Cancer Research. 69: 4674-81. PMID 19470766 DOI: 10.1158/0008-5472.Can-09-0146  0.351
2009 Sudarshan S, Sourbier C, Kong HS, Block K, Valera Romero VA, Yang Y, Galindo C, Mollapour M, Scroggins B, Goode N, Lee MJ, Gourlay CW, Trepel J, Linehan WM, Neckers L. Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species. Molecular and Cellular Biology. 29: 4080-90. PMID 19470762 DOI: 10.1128/Mcb.00483-09  0.355
2009 Linehan WM, Pinto PA, Bratslavsky G, Pfaffenroth E, Merino M, Vocke CD, Toro JR, Bottaro D, Neckers L, Schmidt LS, Srinivasan R. Hereditary kidney cancer: unique opportunity for disease-based therapy. Cancer. 115: 2252-61. PMID 19402075 DOI: 10.1002/Cncr.24230  0.684
2009 Atkins MB, Bukowski RM, Escudier BJ, Figlin RA, Hudes GH, Kaelin WG, Linehan WM, McDermott DF, Mier JW, Pedrosa I, Rini BI, Signoretti S, Sosman JA, Teh BT, Wood CG, et al. Innovations and challenges in renal cancer: summary statement from the Third Cambridge Conference. Cancer. 115: 2247-51. PMID 19402064 DOI: 10.1002/Cncr.24229  0.418
2009 Shen HC, Adem A, Ylaya K, Wilson A, He M, Lorang D, Hewitt SM, Pechhold K, Harlan DM, Lubensky IA, Schmidt LS, Linehan WM, Libutti SK. Deciphering von Hippel-Lindau (VHL/Vhl)-associated pancreatic manifestations by inactivating Vhl in specific pancreatic cell populations. Plos One. 4: e4897. PMID 19340311 DOI: 10.1371/Journal.Pone.0004897  0.353
2009 Mushinski JF, Nguyen P, Stevens LM, Khanna C, Lee S, Chung EJ, Lee MJ, Kim YS, Linehan WM, Horisberger MA, Trepel JB. Inhibition of tumor cell motility by the interferon-inducible GTPase MxA. The Journal of Biological Chemistry. 284: 15206-14. PMID 19297326 DOI: 10.1074/Jbc.M806324200  0.379
2009 Rosner I, Bratslavsky G, Pinto PA, Linehan WM. The clinical implications of the genetics of renal cell carcinoma Urologic Oncology: Seminars and Original Investigations. 27: 131-136. PMID 19285230 DOI: 10.1016/J.Urolonc.2008.11.001  0.474
2009 Grubb RL, Deng J, Pinto PA, Mohler JL, Chinnaiyan A, Rubin M, Linehan WM, Liotta LA, Petricoin EF, Wulfkuhle JD. Pathway biomarker profiling of localized and metastatic human prostate cancer reveal metastatic and prognostic signatures. Journal of Proteome Research. 8: 3044-54. PMID 19275204 DOI: 10.1021/Pr8009337  0.337
2009 Linehan WM, Rubin JS, Bottaro DP. VHL loss of function and its impact on oncogenic signaling networks in clear cell renal cell carcinoma. The International Journal of Biochemistry & Cell Biology. 41: 753-6. PMID 18950731 DOI: 10.1016/J.Biocel.2008.09.024  0.665
2009 Cherkasova E, Malinzak E, Rao S, Senchenko VN, Kudryavtseva AV, Kiselev LL, Takahashi Y, Harashima N, Linehan WM, Srinivasan R, Lerman MI, Childs RW. Loss of Function of the VHL Tumor Suppressor Gene Resurrects An Endogenous Retrovirus in Kidney Cancer That Encodes a Tumor Antigen Targeted by Allogeneic T-Cells Following Hematopoietic Cell Transplantation (HCT). Blood. 114: 467-467. DOI: 10.1182/Blood.V114.22.467.467  0.42
2009 Boris RS, Proano M, Rogers CG, Linehan WM, Pinto PA, Bratslavsky G. ROBOTIC ASSISTED PARTIAL NEPHRECTOMY FOR MULTIPLE RENAL MASSES: FEASIBILITY AND RESULTS OF INITIAL EXPERIENCE The Journal of Urology. 181: 536. DOI: 10.1016/S0022-5347(09)61512-3  0.445
2009 Kaye DR, Proano JM, Boris RS, Pinto PA, Linehan WM, Gennady B. ROBOTIC ASSISTED PARTIAL NEPHRECTOMY FOR HEREDITARY RENAL CANCERS: THE NCI EXPERIENCE Journal of Urology. 181: 468-469. DOI: 10.1016/S0022-5347(09)61327-6  0.374
2009 Liu NW, Khurana KK, Sanford TH, Aprelikova O, Worrell R, Liu J, Gillespie J, Yang Y, Srinivasan R, Bechert CJ, Merino M, Pinto PA, Linehan WM, Bratslavsky G. IMPACT OF ISCHEMIA AND TISSUE PROCUREMENT CONDITIONS ON GENE EXPRESSION IN RENAL CELL CARCINOMA Journal of Urology. 181: 155-156. DOI: 10.1016/S0022-5347(09)60447-X  0.408
2008 Rogers CG, Metwalli A, Blatt AM, Bratslavsky G, Menon M, Linehan WM, Pinto PA. Robotic partial nephrectomy for renal hilar tumors: a multi-institutional analysis. The Journal of Urology. 180: 2353-6; discussion 2. PMID 18930263 DOI: 10.1016/J.Juro.2008.08.022  0.404
2008 Eisenhofer G, Huynh TT, Elkahloun A, Morris JC, Bratslavsky G, Linehan WM, Zhuang Z, Balgley BM, Lee CS, Mannelli M, Lenders JW, Bornstein SR, Pacak K. Differential expression of the regulated catecholamine secretory pathway in different hereditary forms of pheochromocytoma. American Journal of Physiology. Endocrinology and Metabolism. 295: E1223-33. PMID 18854424 DOI: 10.1152/Ajpendo.90591.2008  0.332
2008 Butman JA, Linehan WM, Lonser RR. Neurologic manifestations of von Hippel-Lindau disease. Jama. 300: 1334-42. PMID 18799446 DOI: 10.1001/Jama.300.11.1334  0.376
2008 Linehan WM. Kidney cancer: Opportunity for disease specific targeted therapy Urologic Oncology: Seminars and Original Investigations. 26: 542. PMID 18774470 DOI: 10.1016/J.Urolonc.2008.03.014  0.479
2008 Rogers CG, Linehan WM, Pinto PA. Robotic nephrectomy for kidney cancer in a horseshoe kidney with renal vein tumor thrombus: novel technique for thrombectomy. Journal of Endourology / Endourological Society. 22: 1561-3; discussion 1. PMID 18721039 DOI: 10.1089/End.2008.0043  0.432
2008 Nickerson ML, Jaeger E, Shi Y, Durocher JA, Mahurkar S, Zaridze D, Matveev V, Janout V, Kollarova H, Bencko V, Navratilova M, Szeszenia-Dabrowska N, Mates D, Mukeria A, Holcatova I, ... ... Linehan WM, et al. Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 4726-34. PMID 18676741 DOI: 10.1158/1078-0432.Ccr-07-4921  0.485
2008 Signoretti S, Bratslavsky G, Waldman FM, Reuter VE, Haaga J, Merino M, Thomas GV, Pins MR, Libermann T, Gillespie J, Tomaszewski JE, Compton CC, Hruszkewycz A, Linehan WM, Atkins MB. Tissue-based research in kidney cancer: current challenges and future directions. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 3699-705. PMID 18559586 DOI: 10.1158/1078-0432.Ccr-07-4733  0.406
2008 Johnson A, Sudarshan S, Liu J, Linehan WM, Pinto PA, Bratslavsky G. Feasibility and outcomes of repeat partial nephrectomy. The Journal of Urology. 180: 89-93; discussion 93. PMID 18485404 DOI: 10.1016/J.Juro.2008.03.030  0.447
2008 Pfaffenroth EC, Linehan WM. Genetic basis for kidney cancer: Opportunity for disease-specific approaches to therapy Expert Opinion On Biological Therapy. 8: 779-790. PMID 18476789 DOI: 10.1517/14712598.8.6.779  0.466
2008 Hasumi H, Baba M, Hong SB, Hasumi Y, Huang Y, Yao M, Valera VA, Linehan WM, Schmidt LS. Identification and characterization of a novel folliculin-interacting protein FNIP2. Gene. 415: 60-7. PMID 18403135 DOI: 10.1016/J.Gene.2008.02.022  0.414
2008 Lee SJ, Lattouf JB, Xanthopoulos J, Linehan WM, Bottaro DP, Vasselli JR. Von Hippel-Lindau tumor suppressor gene loss in renal cell carcinoma promotes oncogenic epidermal growth factor receptor signaling via Akt-1 and MEK-1. European Urology. 54: 845-53. PMID 18243508 DOI: 10.1016/J.Eururo.2008.01.010  0.627
2008 Yang Y, Padilla-Nash HM, Vira MA, Abu-Asab MS, Val D, Worrell R, Tsokos M, Merino MJ, Pavlovich CP, Ried T, Linehan WM, Vocke CD. The UOK 257 cell line: a novel model for studies of the human Birt-Hogg-Dubé gene pathway. Cancer Genetics and Cytogenetics. 180: 100-9. PMID 18206534 DOI: 10.1016/J.Cancergencyto.2007.10.010  0.45
2008 Baba M, Furihata M, Hong SB, Tessarollo L, Haines DC, Southon E, Patel V, Igarashi P, Alvord WG, Leighty R, Yao M, Bernardo M, Ileva L, Choyke P, Warren MB, ... ... Linehan WM, et al. Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys. Journal of the National Cancer Institute. 100: 140-54. PMID 18182616 DOI: 10.1093/Jnci/Djm288  0.408
2008 Rogers C, Metwalli A, Blatt A, Bratslavsky G, Linehan WM, Pinto PA. ROBOTIC PARTIAL NEPHRECTOMY FOR RENAL HILAR TUMORS Journal of Urology. 179: 216-216. DOI: 10.1016/S0022-5347(08)60622-9  0.377
2008 Khurana K, Albert P, Gautam R, Pinto PA, Linehan WM, Bratslavsky G. TYPE OF VHL MUTATION AND TUMOR SIZE AFFECT GROWTH RATES OF RENAL MASSES IN VHL PATIENTS Journal of Urology. 179: 133-133. DOI: 10.1016/S0022-5347(08)60381-X  0.39
2008 Valera VA, Walter BA, Linehan WM, Merino MJ. PROTEOMIC PROFILING IDENTIFIES KEY REGULATORY METABOLIC ENZYMES AND STRESS PROTEINS DIFFERENTIALLY EXPRESSED IN RENAL CELL CARCINOMAS Journal of Urology. 179: 93-93. DOI: 10.1016/S0022-5347(08)60272-4  0.374
2008 Rogers CG, Singh A, Blatt AM, Linehan WM, Pinto PA. Robotic Partial Nephrectomy for Complex Renal Tumors: Surgical Technique European Urology. 53: 514-523. DOI: 10.1016/J.Eururo.2007.09.047  0.42
2008 Bottaro DP, Tan N, Linehan WM. Regulation of angiogenesis by von Hippel Lindau protein and HIF2 Angiogenesis: An Integrative Approach From Science to Medicine. 181-191. DOI: 10.1007/978-0-387-71518-6_16  0.596
2007 Bratslavsky G, Liu JJ, Johnson AD, Sudarshan S, Choyke PL, Linehan WM, Pinto PA. Salvage partial nephrectomy for hereditary renal cancer: feasibility and outcomes. The Journal of Urology. 179: 67-70. PMID 17997447 DOI: 10.1016/J.Juro.2007.08.150  0.433
2007 Williams CR, Tabios R, Linehan WM, Neckers L. Intratumor injection of the Hsp90 inhibitor 17AAG decreases tumor growth and induces apoptosis in a prostate cancer xenograft model. The Journal of Urology. 178: 1528-32. PMID 17707057 DOI: 10.1016/J.Juro.2007.05.120  0.307
2007 Bratslavsky G, Sudarshan S, Neckers L, Linehan WM. Pseudohypoxic pathways in renal cell carcinoma Clinical Cancer Research. 13: 4667-4671. PMID 17699843 DOI: 10.1158/1078-0432.Ccr-06-2510  0.368
2007 Brouwers FM, Gläsker S, Nave AF, Vortmeyer AO, Lubensky I, Huang S, Abu-Asab MS, Eisenhofer G, Weil RJ, Park DM, Linehan WM, Pacak K, Zhuang Z. Proteomic profiling of von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2 pheochromocytomas reveals different expression of chromogranin B. Endocrine-Related Cancer. 14: 463-71. PMID 17639059 DOI: 10.1677/Erc-06-0038  0.301
2007 Grubb RL, Franks ME, Toro J, Middelton L, Choyke L, Fowler S, Torres-Cabala C, Glenn GM, Choyke P, Merino MJ, Zbar B, Pinto PA, Srinivasan R, Coleman JA, Linehan WM. Hereditary leiomyomatosis and renal cell cancer: a syndrome associated with an aggressive form of inherited renal cancer. The Journal of Urology. 177: 2074-9; discussion 2. PMID 17509289 DOI: 10.1016/J.Juro.2007.01.155  0.498
2007 Vira MA, Novakovic KR, Pinto PA, Linehan WM. Genetic basis of kidney cancer: A model for developing molecular-targeted therapies Bju International. 99: 1223-1229. PMID 17441915 DOI: 10.1111/J.1464-410X.2007.06814.X  0.344
2007 Begnami MD, Quezado M, Pinto P, Linehan WM, Merino M. Adenoid cystic/basal cell carcinoma of the prostate: Review and update Archives of Pathology and Laboratory Medicine. 131: 637-640. PMID 17425398 DOI: 10.1043/1543-2165(2007)131[637:Abccot]2.0.Co;2  0.344
2007 Mai PL, Korde L, Kramer J, Peters J, Mueller CM, Pfeiffer S, Stratakis CA, Pinto PA, Bratslavsky G, Merino M, Choyke P, Linehan WM, Greene MH. A possible new syndrome with growth-hormone secreting pituitary adenoma, colonic polyposis, lipomatosis, lentigines and renal carcinoma in association with familial testicular germ cell malignancy: A case report. Journal of Medical Case Reports. 1: 9. PMID 17411461 DOI: 10.1186/1752-1947-1-9  0.39
2007 Chow WH, Linehan WM, Devesa SS. Re: Rising incidence of small renal masses: A need to reassess treatment effect [1] Journal of the National Cancer Institute. 99: 569-570. PMID 17406001 DOI: 10.1093/Jnci/Djk114  0.361
2007 Catherino WH, Mayers CM, Mantzouris T, Armstrong AY, Linehan WM, Segars JH. Compensatory alterations in energy homeostasis characterized in uterine tumors from hereditary leiomyomatosis and renal cell cancer. Fertility and Sterility. 88: 1039-1048. PMID 17383644 DOI: 10.1016/J.Fertnstert.2006.11.198  0.436
2007 Sudarshan S, Pinto PA, Neckers L, Linehan WM. Mechanisms of disease: Hereditary leiomyomatosis and renal cell cancer - A distinct form of hereditary kidney cancer Nature Clinical Practice Urology. 4: 104-110. PMID 17287871 DOI: 10.1038/Ncpuro0711  0.508
2007 Srinivasan R, Linehan WM. Antiangiogenic therapy in renal cell carcinoma: from concept to reality. Nature Clinical Practice. Urology. 4: 74-5. PMID 17287865 DOI: 10.1038/ncpuro0705  0.301
2007 Linehan WM, Pinto PA, Srinivasan R, Merino M, Choyke P, Choyke L, Coleman J, Toro J, Glenn G, Vocke C, Zbar B, Schmidt LS, Bottaro D, Neckers L. Identification of the genes for kidney cancer: opportunity for disease-specific targeted therapeutics. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 671s-679s. PMID 17255292 DOI: 10.1158/1078-0432.Ccr-06-1870  0.65
2007 Atkins MB, Ernstoff MS, Figlin RA, Flaherty KT, George DJ, Kaelin WG, Kwon ED, Libermann TA, Linehan WM, McDermott DF, Ochoa AC, Pantuck AJ, Rini BI, Rosen MA, Sosman JA, et al. Innovations and challenges in renal cell carcinoma: summary statement from the Second Cambridge Conference. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 667s-670s. PMID 17255291 DOI: 10.1158/1078-0432.Ccr-06-2231  0.424
2007 Zbar B, Glenn G, Merino M, Middelton L, Peterson J, Toro J, Coleman J, Pinto P, Schmidt LS, Choyke P, Linehan WM. Familial renal carcinoma: clinical evaluation, clinical subtypes and risk of renal carcinoma development. The Journal of Urology. 177: 461-5; discussion 46. PMID 17222609 DOI: 10.1016/J.Juro.2006.09.037  0.424
2007 Sudarshan S, Linehan WM, Neckers L. HIF and fumarate hydratase in renal cancer British Journal of Cancer. 96: 403-407. PMID 17211469 DOI: 10.1038/sj.bjc.6603547  0.314
2007 Vira M, Linehan WM. Expanding the Morphological and Molecular Genetic Phenotype of Kidney Cancer Journal of Urology. 177: 10-11. PMID 17161990 DOI: 10.1016/J.Juro.2006.10.011  0.354
2007 Schinstine M, Filie AC, Torres-Cabala C, Abati A, Linehan WM, Merino M. Fine-needle aspiration of a Xp11.2 translocation/TFE3 fusion renal cell carcinoma metastatic to the lung: report of a case and review of the literature. Diagnostic Cytopathology. 34: 751-6. PMID 17121198 DOI: 10.1002/Dc.20548  0.42
2007 Valera VA, Tapia EL, Teller L, Roberts DD, Linehan WM, Merino MJ. Protein expression profiling in the spectrum of renal tumors The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A181-A  0.411
2007 Srinivasan R, Linehan WM. Antiangiogenic therapy in renal cell carcinoma: From concept to reality: Commentary Nature Clinical Practice Urology. 4: 74-75. DOI: 10.1038/Ncpuro0705  0.416
2007 Johnson A, Bratslavsky G, Sudarshan S, Liu J, Linehan WM, Pinto PA. 1298: Feasibility and Outcomes of Repeat Partial Nephrectomy on the Same Kidney: NCI Experience Journal of Urology. 177: 427-427. DOI: 10.1016/S0022-5347(18)31512-X  0.313
2007 Srinivasan R, Vira MA, Fowler S, Cartwright E, Lattouf JB, Albert PS, Carrasquillo J, Ivy SP, Coleman JA, Neckers L, Choyke PL, Pinto PA, Linehan WM. 1242: A Phase 2 Study of 17-Allylamino-17-Demethoxygeldanamycin (17AAG) in Patients with Von Hippel Lindau (VHL) Disease and Renal Tumors Journal of Urology. 177: 409-409. DOI: 10.1016/S0022-5347(18)31456-3  0.418
2007 Rogers CG, Dhanani NN, Johnson A, Bratslavsky G, Gautam R, Peterson J, Pinto PA, Linehan WM. 910: Growth Rates of Observed Renal Tumors in Patients with Birt-Hogg-Dube Syndrome Journal of Urology. 177: 302-302. DOI: 10.1016/S0022-5347(18)31138-8  0.405
2007 Liu J, Bratslavsky G, Sudarshan S, Johnson A, Pinto PA, Linehan WM. 903: The Influence of VHL Mutation Type on the Need for Reoperative Surgery for Renal Cell Carcinoma Journal of Urology. 177: 300-300. DOI: 10.1016/S0022-5347(18)31131-5  0.403
2007 Bratslavsky G, Albert PS, Liu J, Gautam R, Rogers CG, Dhanani NN, Peterson J, Choyke L, Choyke PL, Pinto PA, Linehan WM. 647: Growth Rates of Hereditary Clear Cell Renal Carcinomas Journal of Urology. 177: 217-217. DOI: 10.1016/S0022-5347(18)30887-5  0.413
2007 Rogers CG, Sudarshan S, Singh A, Vira MA, Coleman JA, Linehan WM, Pinto PA. 45: Long-Term Assessment of Adrenal Function and Cancer Control after Partial Adrenalectomy for Adrenal Tumors Journal of Urology. 177: 16-16. DOI: 10.1016/S0022-5347(18)30310-0  0.314
2007 Blansfield JA, Choyke L, Morita SY, Choyke PL, Pingpank JF, Alexander HR, Seidel G, Shutack Y, Yuldasheva N, Eugeni M, Bartlett DL, Glenn GM, Middelton L, Linehan WM, Libutti SK. Clinical, genetic and radiographic analysis of 108 patients with von Hippel-Lindau disease (VHL) manifested by pancreatic neuroendocrine tumors (PNETs) Surgery. 142: 814-818.e2. DOI: 10.1016/J.Surg.2007.09.012  0.323
2006 Jarrell ST, Vortmeyer AO, Linehan WM, Oldfield EH, Lonser RR. Metastases to hemangioblastomas in von Hippel-Lindau disease. Journal of Neurosurgery. 105: 256-63. PMID 17219831 DOI: 10.3171/Jns.2006.105.2.256  0.346
2006 Brouwers FM, Elkahloun AG, Munson PJ, Eisenhofer G, Barb J, Linehan WM, Lenders JWM, De Krijger R, Mannelli M, Udelsman R, Ocal IT, Shulkin BL, Bornstein SR, Breza J, Ksinantova L, et al. Gene expression profiling of benign and malignant pheochromocytoma Annals of the New York Academy of Sciences. 1073: 541-556. PMID 17102123 DOI: 10.1196/Annals.1353.058  0.37
2006 Huynh TT, Pacak K, Wong DL, Linehan WM, Goldstein DS, Elkahloun AG, Munson PJ, Eisenhofer G. Transcriptional regulation of phenylethanolamine N-methyltransferase in pheochromocytomas from patients with von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2. Annals of the New York Academy of Sciences. 1073: 241-52. PMID 17102092 DOI: 10.1196/Annals.1353.026  0.305
2006 Lattouf JB, Srinivasan R, Pinto PA, Linehan WM, Neckers L. Mechanisms of disease: The role of heat-shock protein 90 in genitourinary malignancy Nature Clinical Practice Urology. 3: 590-601. PMID 17088927 DOI: 10.1038/Ncpuro0604  0.371
2006 Sudarshan S, Linehan WM. Genetic Basis of Cancer of the Kidney Seminars in Oncology. 33: 544-551. PMID 17045083 DOI: 10.1053/J.Seminoncol.2006.06.008  0.469
2006 Baba M, Hong SB, Sharma N, Warren MB, Nickerson ML, Iwamatsu A, Esposito D, Gillette WK, Hopkins RF, Hartley JL, Furihata M, Oishi S, Zhen W, Burke TR, Linehan WM, et al. Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. Proceedings of the National Academy of Sciences of the United States of America. 103: 15552-7. PMID 17028174 DOI: 10.1073/Pnas.0603781103  0.335
2006 Brouwers FM, Eisenhofer G, Tao JJ, Kant JA, Adams KT, Linehan WM, Pacak K. High frequency of SDHB germline mutations in patients with malignant catecholamine-producing paragangliomas: Implications for genetic testing Journal of Clinical Endocrinology and Metabolism. 91: 4505-4509. PMID 16912137 DOI: 10.1210/Jc.2006-0423  0.352
2006 Woldemichael GM, Vasselli JR, Gardella RS, McKee TC, Linehan WM, McMahon JB. Development of a cell-based reporter assay for screening of inhibitors of hypoxia-inducible factor 2-induced gene expression. Journal of Biomolecular Screening. 11: 678-87. PMID 16858007 DOI: 10.1177/1087057106289234  0.348
2006 Riss J, Khanna C, Koo S, Chandramouli GV, Yang HH, Hu Y, Kleiner DE, Rosenwald A, Schaefer CF, Ben-Sasson SA, Yang L, Powell J, Kane DW, Star RA, Aprelikova O, ... ... Linehan WM, et al. Cancers as wounds that do not heal: differences and similarities between renal regeneration/repair and renal cell carcinoma. Cancer Research. 66: 7216-24. PMID 16849569 DOI: 10.1158/0008-5472.Can-06-0040  0.449
2006 Linehan WM. Identification of the genes for kidney cancer. Cancer Biology & Therapy. 5: 696-9. PMID 16775424 DOI: 10.4161/Cbt.5.6.2948  0.389
2006 Davis IJ, Kim JJ, Ozsolak F, Widlund HR, Rozenblatt-Rosen O, Granter SR, Du J, Fletcher JA, Denny CT, Lessnick SL, Linehan WM, Kung AL, Fisher DE. Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers. Cancer Cell. 9: 473-84. PMID 16766266 DOI: 10.1016/J.Ccr.2006.04.021  0.402
2006 Kim CM, Vocke C, Torres-Cabala C, Yang Y, Schmidt L, Walther M, Linehan WM. Expression of hypoxia inducible factor-1alpha and 2alpha in genetically distinct early renal cortical tumors. The Journal of Urology. 175: 1908-14. PMID 16600797 DOI: 10.1016/S0022-5347(05)00890-6  0.386
2006 Hanson JA, Gillespie JW, Grover A, Tangrea MA, Chuaqui RF, Emmert-Buck MR, Tangrea JA, Libutti SK, Linehan WM, Woodson KG. Gene promoter methylation in prostate tumor-associated stromal cells. Journal of the National Cancer Institute. 98: 255-61. PMID 16478744 DOI: 10.1093/Jnci/Djj051  0.342
2006 Grubb RL, Choyke PL, Pinto PA, Linehan WM, Walther MM. Management of von Hippel-Lindau-associated kidney cancer. Nature Clinical Practice. Urology. 2: 248-55. PMID 16474836 DOI: 10.1038/Ncpuro0179  0.474
2006 Lee SJ, Bratslavsky G, Venzon D, Peterson J, Gautam R, Pinto PA, Choyke PL, Wood BJ, Walther MM, Linehan WM, Coleman JA. 1090: The Effect of Radiofrequency Ablation of Renal Tumors on Renal Function Journal of Urology. 175: 350-351. DOI: 10.1016/S0022-5347(18)33315-9  0.439
2006 Bratslavsky G, Lee SJ, Corbin NS, Dhanani NN, Choyke LT, Peterson JQ, Gautam R, Srinivasan R, Peter A, Coleman JA, Linehan WM. 717: Does Type of VHL Mutation Determine Metastatic Potential of Renal Cell Carcinoma? NCI Experience of 17 Years Journal of Urology. 175: 232-232. DOI: 10.1016/S0022-5347(18)32953-7  0.422
2006 Lee SJ, Bratslavsky G, Xanthopoulos J, Bullock A, Elahi E, Vasselli JR, Linehan WM. 375: Use of Short Hairpin-Rna to Target the Epidermal Growth Factor Receptor in 786.0 Renal Cell Cancer Line Results in Effective Abrogation of Tumor Growth in a Murine Xenograft Model Journal of Urology. 175: 123-123. DOI: 10.1016/S0022-5347(18)32631-4  0.385
2006 Vira MA, Keuer B, Novakovic K, Walther MM, Linehan WM, Coleman JA, Pinto PA. 78: Impact of Renal Arterial Occlusion During Laparoscopic Partial Nephrectomy Journal of Urology. 175: 26-26. DOI: 10.1016/S0022-5347(18)32345-0  0.347
2006 Rothman A, Glenn G, Choyke L, Srinivasan R, Linehan WM, Cowen EW. Multiple painful cutaneous nodules and renal mass Journal of the American Academy of Dermatology. 55: 683-686. DOI: 10.1016/J.Jaad.2006.06.026  0.322
2005 Bottaro DP, Linehan WM. Multifocal renal cancer: Genetic basis and its medical relevance Clinical Cancer Research. 11: 7206-7208. PMID 16243789 DOI: 10.1158/1078-0432.Ccr-05-1343  0.611
2005 Best CJ, Gillespie JW, Yi Y, Chandramouli GV, Perlmutter MA, Gathright Y, Erickson HS, Georgevich L, Tangrea MA, Duray PH, González S, Velasco A, Linehan WM, Matusik RJ, Price DK, et al. Molecular alterations in primary prostate cancer after androgen ablation therapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 6823-34. PMID 16203770 DOI: 10.1158/1078-0432.Ccr-05-0585  0.325
2005 Isaacs JS, Jung YJ, Mole DR, Lee S, Torres-Cabala C, Chung YL, Merino M, Trepel J, Zbar B, Toro J, Ratcliffe PJ, Linehan WM, Neckers L. HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability. Cancer Cell. 8: 143-53. PMID 16098467 DOI: 10.1016/J.Ccr.2005.06.017  0.467
2005 Warburton HE, Brady M, Vlatković N, Linehan WM, Parsons K, Boyd MT. p53 regulation and function in renal cell carcinoma. Cancer Research. 65: 6498-503. PMID 16061625 DOI: 10.1158/0008-5472.CAN-05-0017  0.3
2005 Vocke CD, Yang Y, Pavlovich CP, Schmidt LS, Nickerson ML, Torres-Cabala CA, Merino MJ, Walther MM, Zbar B, Linehan WM. High frequency of somatic frameshift BHD gene mutations in Birt-Hogg-Dubé-associated renal tumors. Journal of the National Cancer Institute. 97: 931-5. PMID 15956655 DOI: 10.1093/Jnci/Dji154  0.447
2005 Diner EK, Williams CR, Behari A, Pinto PA, Linehan WM, Walther MM. Metastatic renal cell carcinoma to contralateral ureter presenting as acute obstructive renal failure after radical nephrectomy. Urology. 65: 1001. PMID 15882744 DOI: 10.1016/J.Urology.2004.11.036  0.434
2005 Schmidt LS, Nickerson ML, Warren MB, Glenn GM, Toro JR, Merino MJ, Turner ML, Choyke PL, Sharma N, Peterson J, Morrison P, Maher ER, Walther MM, Zbar B, Linehan WM. Germline BHD-mutation spectrum and phenotype analysis of a large cohort of families with Birt-Hogg-Dubé syndrome. American Journal of Human Genetics. 76: 1023-33. PMID 15852235 DOI: 10.1086/430842  0.323
2005 Pavlovich CP, Grubb RL, Hurley K, Glenn GM, Toro J, Schmidt LS, Torres-Cabala C, Merino MJ, Zbar B, Choyke P, Walther MM, Linehan WM. Evaluation and management of renal tumors in the Birt-Hogg-Dubé syndrome. The Journal of Urology. 173: 1482-6. PMID 15821464 DOI: 10.1097/01.Ju.0000154629.45832.30  0.419
2005 Vogel TW, Brouwers FM, Lubensky IA, Vortmeyer AO, Weil RJ, Walther MM, Oldfield EH, Linehan WM, Pacak K, Zhuang Z. Differential expression of erythropoietin and its receptor in von hippel-lindau-associated and multiple endocrine neoplasia type 2-associated pheochromocytomas. The Journal of Clinical Endocrinology and Metabolism. 90: 3747-51. PMID 15769989 DOI: 10.1210/Jc.2004-1899  0.337
2005 Matyakhina L, Freedman RJ, Bourdeau I, Wei M, Stergiopoulos SG, Chidakel A, Walther M, Abu-Asab M, Tsokos M, Keil M, Toro J, Linehan WM, Stratakis CA. Hereditary leiomyomatosis associated with bilateral, massive, macronodular adrenocortical disease and atypical cushing syndrome: a clinical and molecular genetic investigation. The Journal of Clinical Endocrinology and Metabolism. 90: 3773-3779. PMID 15741255 DOI: 10.1210/Jc.2004-2377  0.373
2005 Linehan WM, Grubb RL, Coleman JA, Zbar B, Walther MM. The genetic basis of cancer of kidney cancer: Implications for gene-specific clinical management Bju International, Supplement. 95: 2-7. PMID 15720328 DOI: 10.1111/J.1464-410X.2005.05189.X  0.364
2005 Lee YS, Vortmeyer AO, Lubensky IA, Vogel TW, Ikejiri B, Ferlicot S, Benoît G, Giraud S, Oldfield EH, Linehan WM, Teh BT, Richard S, Zhuang Z. Coexpression of erythropoietin and erythropoietin receptor in von Hippel-Lindau disease-associated renal cysts and renal cell carcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 1059-64. PMID 15709172  0.385
2005 Gannot G, Gillespie JW, Chuaqui RF, Tangrea MA, Linehan WM, Emmert-Buck MR. Histomathematical analysis of clinical specimens: challenges and progress. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 53: 177-85. PMID 15684330 DOI: 10.1369/Jhc.4A6457.2005  0.315
2005 Srinivasan R, Linehan WM. Targeted for destruction: The molecular basis for development of novel therapeutic strategies in renal cell cancer Journal of Clinical Oncology. 23: 410-412. PMID 15572728 DOI: 10.1200/Jco.2005.09.907  0.434
2005 Stevens J, Nichelson E, Linehan WM, Thompson N, Liewehr D, Venzon D, Walther MM. Risk factors for skin breakdown after renal and adrenal surgery. Urology. 64: 246-9. PMID 15302471 DOI: 10.1016/J.Urology.2004.03.024  0.323
2005 Warburton HE, Brady M, Vlatković N, Linehan WM, Parsons K, Boyd MT. p53 Regulation and Function in Renal Cell Carcinoma Cancer Research. 65: 6498-6503. DOI: 10.1158/0008-5472.Can-05-0017  0.416
2005 Grubb RL, Franks ME, Toro JR, Hurley K, Glenn GM, Choyke P, Coleman J, Torres-Cabala C, Merino MJ, Zbar B, Walther MM, Linehan WM. 1398: Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC): An Aggressive form of Inherited Renal Cancer Journal of Urology. 173: 379-379. DOI: 10.1016/S0022-5347(18)35532-0  0.46
2005 Coleman J, Singh A, Pinto PA, Phillips J, Pritchard WF, Wray-Cahen D, Linehan WM, Walther MM, Wood BJ. 990: Radiofrequency Assisted Laparoscopic Partial Nephrectomy in Hereditary Kidney Cancer: Clinical and Histologic Results Journal of Urology. 173: 268-268. DOI: 10.1016/S0022-5347(18)35146-2  0.394
2005 Grubb RL, Corbin NS, Choyke P, Glenn GM, Hurley K, Pinto PA, Zbar B, Linehan WM, Walther MM. 980: Analysis of 3-CM Tumor Size Threshold for Intervention in Patients with Birt-Hogg-Dubé and Hereditary Papillary Renal Cancer Journal of Urology. 173: 265-265. DOI: 10.1016/S0022-5347(18)35136-X  0.428
2005 Salazar K, Bottaro D, Vasselli J, Neckers L, Linehan WM, Coleman J. 585: Targeted Drug Therapies and Cellular Response in Human Bladder Cancer Cell Lines Journal of Urology. 173: 160-160. DOI: 10.1016/S0022-5347(18)34825-0  0.553
2005 Warburton HE, Parsons KF, Linehan WM, Boyd MT. 379: MDM2 Expression and P53 Mutation in Renal Cell Carcinoma. Journal of Urology. 173: 104-104. DOI: 10.1016/S0022-5347(18)34632-9  0.413
2005 Kim CM, Vocke K, Torres-Cabala C, Yang Y, Walther MM, Linehan WM. 346: Expression of Hypoxia Inducble Factors in Genetically Distinct Early Renal Cortical Tumors Journal of Urology. 173: 95-95. DOI: 10.1016/S0022-5347(18)34599-3  0.394
2004 Stoyanova R, Clapper ML, Bellacosa A, Henske EP, Testa JR, Ross EA, Yeung AT, Nicolas E, Tsichlis N, Li YS, Linehan WM, Howard S, Campbell KS, Godwin AK, Boman BM, et al. Altered gene expression in phenotypically normal renal cells from carriers of tumor suppressor gene mutations. Cancer Biology & Therapy. 3: 1313-21. PMID 15662135 DOI: 10.4161/Cbt.3.12.1459  0.43
2004 Figg WD, Franks ME, Venzon D, Duray P, Cox MC, Linehan WM, Van Bingham W, Eastham JA, Reed E, Sartor O. Gleason score and pretreatment prostate-specific antigen in survival among patients with stage D2 prostate cancer. World Journal of Urology. 22: 425-30. PMID 15592675 DOI: 10.1007/S00345-004-0443-7  0.334
2004 Tangrea MA, Chuaqui RF, Gillespie JW, Ahram M, Gannot G, Wallis BS, Best CJ, Linehan WM, Liotta LA, Pohida TJ, Bonner RF, Emmert-Buck MR. Expression microdissection: operator-independent retrieval of cells for molecular profiling. Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B. 13: 207-12. PMID 15538110 DOI: 10.1097/01.Pdm.0000135964.31459.Bb  0.304
2004 Alleman WG, Tabios RL, Chandramouli GV, Aprelikova ON, Torres-Cabala C, Mendoza A, Rogers C, Rodgers C, Sopko NA, Linehan WM, Vasselli JR. The in vitro and in vivo effects of re-expressing methylated von Hippel-Lindau tumor suppressor gene in clear cell renal carcinoma with 5-aza-2'-deoxycytidine. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 7011-21. PMID 15501981 DOI: 10.1158/1078-0432.Ccr-04-0516  0.434
2004 Linehan WM, Vasselli J, Srinivasan R, Walther MM, Merino M, Choyke P, Vocke C, Schmidt L, Isaacs JS, Glenn G, Toro J, Zbar B, Bottaro D, Neckers L, Figlin R, et al. Genetic basis of cancer of the kidney: Disease-specific approaches to therapy Clinical Cancer Research. 10: 6282s-6289s. PMID 15448018 DOI: 10.1158/1078-0432.Ccr-050013  0.674
2004 Atkins MB, Avigan DE, Bukowski RM, Childs RW, Dutcher JP, Eisen TG, Figlin RA, Finke JH, Flanigan RC, George DJ, Goldberg SN, Gordon MS, Iliopoulos O, Kaelin WG, Linehan WM, et al. Innovations and challenges in renal cancer: consensus statement from the first international conference. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 6277S-81S. PMID 15448017 DOI: 10.1158/1078-0432.Ccr-040720  0.398
2004 Linehan WM, Zbar B. Focus on kidney cancer Cancer Cell. 6: 223-228. PMID 15380513 DOI: 10.1016/J.Ccr.2004.09.006  0.386
2004 Schmidt LS, Nickerson ML, Angeloni D, Glenn GM, Walther MM, Albert PS, Warren MB, Choyke PL, Torres-Cabala CA, Merino MJ, Brunet J, Bérez V, Borràs J, Sesia G, Middelton L, ... ... Linehan WM, et al. Early onset hereditary papillary renal carcinoma: germline missense mutations in the tyrosine kinase domain of the met proto-oncogene. The Journal of Urology. 172: 1256-61. PMID 15371818 DOI: 10.1097/01.Ju.0000139583.63354.E0  0.408
2004 Duffey BG, Choyke PL, Glenn G, Grubb RL, Venzon D, Linehan WM, Walther MM. The relationship between renal tumor size and metastases in patients with von Hippel-Lindau disease. The Journal of Urology. 172: 63-5. PMID 15201738 DOI: 10.1097/01.ju.0000132127.79974.3f  0.346
2004 Drachenberg DE, Mena OJ, Choyke PL, Linehan WM, Walther MM. Parenchymal sparing surgery for central renal tumors in patients with hereditary renal cancers Journal of Urology. 172: 49-53. PMID 15201735 DOI: 10.1097/01.Ju.0000130930.70356.28  0.454
2004 Warren MB, Torres-Cabala CA, Turner ML, Merino MJ, Matrosova VY, Nickerson ML, Ma W, Linehan WM, Zbar B, Schmidt LS. Expression of Birt-Hogg-Dubé gene mRNA in normal and neoplastic human tissues. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. 17: 998-1011. PMID 15143337 DOI: 10.1038/Modpathol.3800152  0.38
2004 Woodson K, Gillespie J, Hanson J, Emmert-Buck M, Phillips JM, Linehan WM, Tangrea JA. Heterogeneous gene methylation patterns among pre-invasive and cancerous lesions of the prostate: a histopathologic study of whole mount prostate specimens. The Prostate. 60: 25-31. PMID 15129426 DOI: 10.1002/Pros.20013  0.302
2004 Oh S, Terabe M, Pendleton CD, Bhattacharyya A, Bera TK, Epel M, Reiter Y, Phillips J, Linehan WM, Kasten-Sportes C, Pastan I, Berzofsky JA. Human CTLs to wild-type and enhanced epitopes of a novel prostate and breast tumor-associated protein, TARP, lyse human breast cancer cells. Cancer Research. 64: 2610-8. PMID 15059918 DOI: 10.1158/0008-5472.Can-03-2183  0.313
2004 Arlen PM, Figg WD, Gulley J, Cox MC, Linehan WM, Dahut W. National Cancer Institute intramural approach to advanced prostate cancer. Clinical Prostate Cancer. 1: 153-62. PMID 15046690 DOI: 10.3816/Cgc.2002.N.017  0.316
2004 Choo D, Shotland L, Mastroianni M, Glenn G, van Waes C, Linehan WM, Oldfield EH. Endolymphatic sac tumors in von Hippel-Lindau disease. Journal of Neurosurgery. 100: 480-7. PMID 15035284 DOI: 10.3171/Jns.2004.100.3.0480  0.305
2004 Loaiza-Pérez AI, Kenney S, Boswell J, Hollingshead M, Hose C, Linehan WM, Worrell R, Rubinstein L, Sausville EA, Vistica DT. Sensitivity of renal cell carcinoma to aminoflavone: role of CYP1A1. The Journal of Urology. 171: 1688-97. PMID 15017268 DOI: 10.1097/01.ju.0000108860.03389.1b  0.315
2004 Igarashi T, Wynberg J, Srinivasan R, Becknell B, McCoy JP, Takahashi Y, Suffredini DA, Linehan WM, Caligiuri MA, Childs RW. Enhanced cytotoxicity of allogeneic NK cells with killer immunoglobulin-like receptor ligand incompatibility against melanoma and renal cell carcinoma cells. Blood. 104: 170-7. PMID 15016654 DOI: 10.1182/Blood-2003-12-4438  0.341
2004 Maranchie JK, Afonso A, Albert PS, Kalyandrug S, Phillips JL, Zhou S, Peterson J, Ghadimi BM, Hurley K, Riss J, Vasselli JR, Ried T, Zbar B, Choyke P, Walther MM, ... ... Linehan WM, et al. Solid renal tumor severity in von Hippel Lindau disease is related to germline deletion length and location. Human Mutation. 23: 40-6. PMID 14695531 DOI: 10.1002/Humu.10302  0.441
2004 DUFFEY BG, CHOYKE PL, GLENN G, GRUBB RL, VENZON D, LINEHAN WM, WALTHER MM. THE RELATIONSHIP BETWEEN RENAL TUMOR SIZE AND METASTASES IN PATIENTS WITH VON HIPPEL-LINDAU DISEASE Journal of Urology. 172: 63-65. DOI: 10.1097/01.Ju.0000132127.79974.3F  0.454
2004 Duffey BG, Choyke PL, Glenn G, Grubb RL, Venzon D, Linehan WM, Walther MM. 1648: Enhanced Risk of Metastasis with Increasing Renal Tumor Size in Patients with von Hippel-Lindau Disease Journal of Urology. 171: 435-435. DOI: 10.1016/S0022-5347(18)38856-6  0.414
2004 Lee CS, Grubb RL, Franks ME, Coleman JA, Venzon D, Linehan WM, Pinto PA, Walther MM, Phillips J. 1303: Analysis of Laparoscopic Partial Nephrectomy Outcomes for Patients with Familial Renal Cell Carcinoma Versus Sporadic Renal Tumors Journal of Urology. 171: 343-343. DOI: 10.1016/S0022-5347(18)38528-8  0.466
2004 Alleman W, Chandramouli G, Aprelikova O, Tabios R, Linehan W, Vasselli J. 783: Gene Expression Analysis of the Effects of 5-Aza- 2'-Deoxycytidine On Hypermethylated VHL Clear-Cell Kidney Cancer Journal of Urology. 171: 207-207. DOI: 10.1016/S0022-5347(18)38032-7  0.406
2004 Franks ME, Posadas E, Macpherson G, Dahut W, Linehan WM, Price DK, Figg WD. 395: Leukapheresis of Patients with Androgen Independent Prostate Cancer (AIPC) May Enhance in Vitro Isolation of Prostate Cancer Cells Journal of Urology. 171: 104-104. DOI: 10.1016/S0022-5347(18)37657-2  0.303
2004 Coleman JA, Walther MM, Linehan WM, Pinto PA. V215: Laparoscopic Radical Nephrectomy for Level 1 Tumor Thrombus Journal of Urology. 171: 57-57. DOI: 10.1016/S0022-5347(18)37477-9  0.305
2003 Hwang JJ, Uchio EM, Linehan WM, Walther MM. Hereditary kidney cancer Urologic Clinics of North America. 30: 831-842. PMID 14680318 DOI: 10.1016/S0094-0143(03)00054-5  0.442
2003 Linehan WM, Walther MM, Zbar B. The genetic basis of cancer of the kidney Journal of Urology. 170: 2163-2172. PMID 14634372 DOI: 10.1097/01.Ju.0000096060.92397.Ed  0.503
2003 Grubb RL, Calvert VS, Wulkuhle JD, Paweletz CP, Linehan WM, Phillips JL, Chuaqui R, Valasco A, Gillespie J, Emmert-Buck M, Liotta LA, Petricoin EF. Signal pathway profiling of prostate cancer using reverse phase protein arrays. Proteomics. 3: 2142-6. PMID 14595813 DOI: 10.1002/Pmic.200300598  0.326
2003 Yacoub A, Mitchell C, Brannon J, Rosenberg E, Qiao L, McKinstry R, Linehan WM, Su ZS, Sarkar D, Lebedeva IV, Valerie K, Gopalkrishnan RV, Grant S, Fisher PB, Dent P. MDA-7 (interleukin-24) inhibits the proliferation of renal carcinoma cells and interacts with free radicals to promote cell death and loss of reproductive capacity. Molecular Cancer Therapeutics. 2: 623-32. PMID 12883035  0.309
2003 Linehan WM. Editorial: Molecular targeting of the VHL gene pathway in clear cell kidney cancer Journal of Urology. 170: 593-594. PMID 12853837 DOI: 10.1097/01.Ju.0000077210.05543.Ae  0.404
2003 Lonser RR, Glenn GM, Walther M, Chew EY, Libutti SK, Linehan WM, Oldfield EH. von Hippel-Lindau disease The Lancet. 361: 2059-2067. PMID 12814730 DOI: 10.1016/S0140-6736(03)13643-4  0.321
2003 Vasselli JR, Shih JH, Iyengar SR, Maranchie J, Riss J, Worrell R, Torres-Cabala C, Tabios R, Mariotti A, Stearman R, Merino M, Walther MM, Simon R, Klausner RD, Linehan WM. Predicting survival in patients with metastatic kidney cancer by gene-expression profiling in the primary tumor. Proceedings of the National Academy of Sciences of the United States of America. 100: 6958-63. PMID 12777628 DOI: 10.1073/Pnas.1131754100  0.426
2003 Toro JR, Nickerson ML, Wei MH, Warren MB, Glenn GM, Turner ML, Stewart L, Duray P, Tourre O, Sharma N, Choyke P, Stratton P, Merino M, Walther MM, Linehan WM, et al. Mutations in the fumarate hydratase gene cause hereditary leiomyomatosis and renal cell cancer in families in North America. American Journal of Human Genetics. 73: 95-106. PMID 12772087 DOI: 10.1086/376435  0.419
2003 Best CJ, Leiva IM, Chuaqui RF, Gillespie JW, Duray PH, Murgai M, Zhao Y, Simon R, Kang JJ, Green JE, Bostwick DG, Linehan WM, Emmert-Buck MR. Molecular differentiation of high- and moderate-grade human prostate cancer by cDNA microarray analysis. Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B. 12: 63-70. PMID 12766610 DOI: 10.1097/00019606-200306000-00001  0.347
2003 Pavlovich CP, Padilla-Nash H, Wangsa D, Nickerson ML, Matrosova V, Linehan WM, Ried T, Phillips JL. Patterns of aneuploidy in stage IV clear cell renal cell carcinoma revealed by comparative genomic hybridization and spectral karyotyping. Genes, Chromosomes & Cancer. 37: 252-60. PMID 12759923 DOI: 10.1002/Gcc.10209  0.373
2003 Maranchie JK, Linehan WM. Genetic disorders and renal cell carcinoma Urologic Clinics of North America. 30: 133-141. PMID 12580565 DOI: 10.1016/S0094-0143(02)00120-9  0.408
2003 Hwang JJ, Uchio EM, Pavlovich CP, Pautler SE, Libutti SK, Linehan WM, Walther MM. Surgical management of multi-organ visceral tumors in patients with von Hippel-Lindau disease: a single stage approach. The Journal of Urology. 169: 895-8. PMID 12576808 DOI: 10.1097/01.Ju.0000049518.15260.1F  0.305
2003 Zbar B, Klausner R, Linehan WM. Studying cancer families to identify kidney cancer genes. Annual Review of Medicine. 54: 217-33. PMID 12525673 DOI: 10.1146/Annurev.Med.54.101601.152514  0.446
2003 Choyke PL, Glenn GM, Walther MM, Zbar B, Linehan WM. Hereditary renal cancers Radiology. 226: 33-46. PMID 12511666 DOI: 10.1148/Radiol.2261011296  0.48
2003 Marcos HB, Libutti SK, Alexander HR, Lubensky IA, Bartlett DL, Walther MM, Linehan WM, Glenn GM, Choyke PL. Neuroendocrine tumors of the pancreas in von Hippel-Lindau disease: spectrum of appearances at CT and MR imaging with histopathologic comparison. Radiology. 225: 751-8. PMID 12461257 DOI: 10.1148/Radiol.2253011297  0.308
2002 Pavlovich CP, Walther MM, Eyler RA, Hewitt SM, Zbar B, Linehan WM, Merino MJ. Renal tumors in the Birt-Hogg-Dubé syndrome. The American Journal of Surgical Pathology. 26: 1542-52. PMID 12459621 DOI: 10.1097/00000478-200212000-00002  0.479
2002 Feldman AL, Alexander HR, Yang JC, Linehan WM, Eyler RA, Miller MS, Steinberg SM, Libutti SK. Prospective analysis of circulating endostatin levels in patients with renal cell carcinoma. Cancer. 95: 1637-43. PMID 12365010 DOI: 10.1002/Cncr.10845  0.386
2002 Nickerson ML, Warren MB, Toro JR, Matrosova V, Glenn G, Turner ML, Duray P, Merino M, Choyke P, Pavlovich CP, Sharma N, Walther M, Munroe D, Hill R, Maher E, ... ... Linehan WM, et al. Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dubé syndrome. Cancer Cell. 2: 157-64. PMID 12204536 DOI: 10.1016/S1535-6108(02)00104-6  0.434
2002 Koch CA, Mauro D, Walther MM, Linehan WM, Vortmeyer AO, Jaffe R, Pacak K, Chrousos GP, Zhuang Z, Lubensky IA. Pheochromocytoma in von hippel-lindau disease: distinct histopathologic phenotype compared to pheochromocytoma in multiple endocrine neoplasia type 2. Endocrine Pathology. 13: 17-27. PMID 12114747 DOI: 10.1385/Ep:13:1:17  0.369
2002 Maranchie JK, Vasselli JR, Riss J, Bonifacino JS, Linehan WM, Klausner RD. The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma. Cancer Cell. 1: 247-55. PMID 12086861 DOI: 10.1016/S1535-6108(02)00044-2  0.402
2002 Pautler SE, Hewitt SM, Linehan WM, Walther MM. Specimen morcellation after laparoscopic radical nephrectomy: Confirmation of histologic diagnosis using needle biopsy Journal of Endourology. 16: 89-92. PMID 11962561 DOI: 10.1089/089277902753619573  0.352
2002 Zbar B, Alvord WG, Glenn G, Turner M, Pavlovich CP, Schmidt L, Walther M, Choyke P, Weirich G, Hewitt SM, Duray P, Gabril F, Greenberg C, Merino MJ, Toro J, ... Linehan WM, et al. Risk of renal and colonic neoplasms and spontaneous pneumothorax in the Birt-Hogg-Dubé syndrome. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 11: 393-400. PMID 11927500  0.336
2002 Caldwell MC, Hough C, Fürer S, Linehan WM, Morin PJ, Gorospe M. Serial analysis of gene expression in renal carcinoma cells reveals VHL-dependent sensitivity to TNFalpha cytotoxicity. Oncogene. 21: 929-36. PMID 11840338 DOI: 10.1038/Sj.Onc.1205140  0.39
2002 Ahram M, Best CJ, Flaig MJ, Gillespie JW, Leiva IM, Chuaqui RF, Zhou G, Shu H, Duray PH, Linehan WM, Raffeld M, Ornstein DK, Zhao Y, Petricoin EF, Emmert-Buck MR. Proteomic analysis of human prostate cancer. Molecular Carcinogenesis. 33: 9-15. PMID 11807953 DOI: 10.1002/Mc.10019  0.337
2002 Swalwell JI, Vocke CD, Yang Y, Walker JR, Grouse L, Myers SH, Gillespie JW, Bostwick DG, Duray PH, Linehan WM, Emmert-Buck MR. Determination of a minimal deletion interval on chromosome band 8p21 in sporadic prostate cancer. Genes, Chromosomes & Cancer. 33: 201-5. PMID 11793446 DOI: 10.1002/Gcc.10015  0.31
2002 PAUTLER SE, RICHARDS C, LIBUTTI SK, LINEHAN W, WALTHER MM. INTENTIONAL RESECTION OF THE DIAPHRAGM DURING CYTOREDUCTIVE LAPAROSCOPIC RADICAL NEPHRECTOMY Journal of Urology. 167: 48-50. DOI: 10.1016/S0022-5347(05)65380-3  0.389
2002 PAVLOVICH CP, WALTHER MM, CHOYKE PL, PAUTLER SE, CHANG R, LINEHAN W, WOOD BJ. PERCUTANEOUS RADIO FREQUENCY ABLATION OF SMALL RENAL TUMORS: INITIAL RESULTS Journal of Urology. 167: 10-15. DOI: 10.1016/S0022-5347(05)64708-8  0.43
2002 Linehan WM. Editorial: Kidney Cancer—A Unique Opportunity for the Development of Disease Specific Therapy Journal of Urology. 168: 2411-2412. DOI: 10.1016/S0022-5347(05)64156-0  0.311
2001 Chernoff A, Kasparcova V, Linehan WM, Stolle CA. Molecular Analysis of the von Hippel-Lindau Disease Gene Methods in Molecular Medicine. 53: 193-216. PMID 21318797 DOI: 10.1385/1-59259-144-2:193  0.376
2001 Pavlovich CP, Linehan WM, Walther MM. Partial adrenalectomy in patients with multiple adrenal tumors Current Urology Reports. 2: 19-23. PMID 12084290 DOI: 10.1007/S11934-001-0021-0  0.341
2001 Schmidt LS, Warren MB, Nickerson ML, Weirich G, Matrosova V, Toro JR, Turner ML, Duray P, Merino M, Hewitt S, Pavlovich CP, Glenn G, Greenberg CR, Linehan WM, Zbar B. Birt-Hogg-Dubé syndrome, a genodermatosis associated with spontaneous pneumothorax and kidney neoplasia, maps to chromosome 17p11.2. American Journal of Human Genetics. 69: 876-82. PMID 11533913 DOI: 10.1086/323744  0.328
2001 Phillips JL, Pavlovich CP, Walther M, Ried T, Linehan WM. The genetic basis of renal epithelial tumors: Advances in research and its impact on prognosis and therapy Current Opinion in Urology. 11: 463-469. PMID 11493766 DOI: 10.1097/00042307-200109000-00003  0.348
2001 Eisenhofer G, Walther MM, Huynh TT, Li ST, Bornstein SR, Vortmeyer A, Mannelli M, Goldstein DS, Linehan WM, Lenders JW, Pacak K. Pheochromocytomas in von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2 display distinct biochemical and clinical phenotypes. The Journal of Clinical Endocrinology and Metabolism. 86: 1999-2008. PMID 11344198 DOI: 10.1210/Jcem.86.5.7496  0.308
2001 Simsir A, Palacios D, Linehan WM, Merino MJ, Abati A. Detection of loss of heterozygosity at chromosome 3p25-26 in primary and metastatic ovarian clear-cell carcinoma: utilization of microdissection and polymerase chain reaction in archival tissues. Diagnostic Cytopathology. 24: 328-32. PMID 11335962 DOI: 10.1002/Dc.1070  0.365
2001 Pacak K, Fojo T, Goldstein DS, Eisenhofer G, Walther MM, Linehan WM, Bachenheimer L, Abraham J, Wood BJ. Radiofrequency ablation: a novel approach for treatment of metastatic pheochromocytoma. Journal of the National Cancer Institute. 93: 648-9. PMID 11309443 DOI: 10.1093/Jnci/93.8.648  0.322
2001 Phillips JL, Ghadimi BM, Wangsa D, Padilla-Nash H, Worrell R, Hewitt S, Walther M, Linehan WM, Klausner RD, Ried T. Molecular cytogenetic characterization of early and late renal cell carcinomas in von Hippel-Lindau disease. Genes, Chromosomes & Cancer. 31: 1-9. PMID 11284029 DOI: 10.1002/Gcc.1111  0.389
2001 Lei JY, Middleton LP, Guo XD, Duray PH, McWilliams G, Linehan WM, Merino MJ. Pigmented renal clear cell carcinoma with melanocytic differentiation. Human Pathology. 32: 233-6. PMID 11230713 DOI: 10.1053/Hupa.2001.22009  0.465
2001 Pacak K, Linehan WM, Eisenhofer G, Walther MM, Goldstein DS. Recent advances in genetics, diagnosis, localization, and treatment of pheochromocytoma. Annals of Internal Medicine. 134: 315-29. PMID 11182843 DOI: 10.7326/0003-4819-134-4-200102200-00016  0.35
2001 Choyke PL, Pavlovich CP, Daryanani KD, Hewitt SM, Linehan WM, Walther MM. Intraoperative ultrasound during renal parenchymal sparing surgery for hereditary renal cancers: a 10-year experience. The Journal of Urology. 165: 397-400. PMID 11176381 DOI: 10.1097/00005392-200102000-00010  0.431
2001 Pautler SE, Linehan WM, Walther MM. Cytoreductive laparoscopic radical nephrectomythe early experience Urologic Oncology. 6: 193-195. DOI: 10.1016/S1078-1439(01)00138-7  0.337
2001 HERRING JC, ENQUIST EG, CHERNOFF A, LINEHAN WM, CHOYKE PL, WALTHER MM. PARENCHYMAL SPARING SURGERY IN PATIENTS WITH HEREDITARY RENAL CELL CARCINOMA: 10-YEAR EXPERIENCE Journal of Urology. 165: 777-781. DOI: 10.1016/S0022-5347(05)66524-X  0.479
2001 CHERNOFF A, CHOYKE PL, LINEHAN WM, WALTHER MM. PARENCHYMAL SPARING SURGERY IN A PATIENT WITH MULTIPLE BILATERAL PAPILLARY RENAL CANCER Journal of Urology. 165: 1623-1624. DOI: 10.1016/S0022-5347(05)66366-5  0.422
2001 VASSELLI JR, YANG JC, LINEHAN WM, WHITE DE, ROSENBERG SA, WALTHER MM. LACK OF RETROPERITONEAL LYMPHADENOPATHY PREDICTS SURVIVAL OF PATIENTS WITH METASTATIC RENAL CELL CARCINOMA Journal of Urology. 166: 68-72. DOI: 10.1016/S0022-5347(05)66078-8  0.424
2001 ORNSTEIN DK, CINQUANTA M, WEILER S, DURAY PH, EMMERT-BUCK MR, VOCKE CD, LINEHAN WM, FERRETTI JA. EXPRESSION STUDIES AND MUTATIONAL ANALYSIS OF THE ANDROGEN REGULATED HOMEOBOX GENE NKX3.1 IN BENIGN AND MALIGNANT PROSTATE EPITHELIUM Journal of Urology. 165: 1329-1334. DOI: 10.1016/S0022-5347(01)69894-X  0.31
2000 Libutti SK, Choyke PL, Alexander HR, Glenn G, Bartlett DL, Zbar B, Lubensky I, McKee SA, Maher ER, Linehan WM, Walther MM. Clinical and genetic analysis of patients with pancreatic neuroendocrine tumors associated with von Hippel-Lindau disease. Surgery. 128: 1022-1028. PMID 11114638 DOI: 10.1067/Msy.2000.110239  0.344
2000 Mohr VH, Vortmeyer AO, Zhuang Z, Libutti SK, Walther MM, Choyke PL, Zbar B, Linehan WM, Lubensky IA. Histopathology and molecular genetics of multiple cysts and microcystic (serous) adenomas of the pancreas in von Hippel-Lindau patients. The American Journal of Pathology. 157: 1615-21. PMID 11073821 DOI: 10.1016/S0002-9440(10)64799-2  0.309
2000 Ornstein DK, Gillespie JW, Paweletz CP, Duray PH, Herring J, Vocke CD, Topalian SL, Bostwick DG, Linehan WM, Petricoin EF, Emmert-Buck MR. Proteomic analysis of laser capture microdissected human prostate cancer and in vitro prostate cell lines. Electrophoresis. 21: 2235-42. PMID 10892734 DOI: 10.1002/1522-2683(20000601)21:11<2235::Aid-Elps2235>3.0.Co;2-A  0.318
2000 ORNSTEIN DK, LUBENSKY IA, VENZON D, ZBAR B, LINEHAN WM, WALTHER MM. PREVALENCE OF MICROSCOPIC TUMORS IN NORMAL APPEARING RENAL PARENCHYMA OF PATIENTS WITH HEREDITARY PAPILLARY RENAL CANCER Journal of Urology. 163: 431-433. DOI: 10.1016/S0022-5347(05)67893-7  0.495
2000 WALTHER McCM, SHAWKER TH, LIBUTTI SK, LUBENSKY I, CHOYKE PL, VENZON D, LINEHAN WM. A PHASE 2 STUDY OF RADIO FREQUENCY INTERSTITIAL TISSUE ABLATION OF LOCALIZED RENAL TUMORS Journal of Urology. 163: 1424-1427. DOI: 10.1016/S0022-5347(05)67634-3  0.435
2000 WALTHER MM, HERRING J, CHOYKE PL, LINEHAN WM. LAPAROSCOPIC PARTIAL ADRENALECTOMY IN PATIENTS WITH HEREDITARY FORMS OF PHEOCHROMOCYTOMA Journal of Urology. 164: 14-17. DOI: 10.1016/S0022-5347(05)67438-1  0.311
2000 Enquist E, Zambrano N, Zbar B, Linehan WM, Walther MM. Molecular Genetics of Renal Cell Carcinoma Seminars in Urologic Oncology. 14: 79-92. DOI: 10.1007/978-1-59259-229-6_5  0.435
2000 Linehan WM. Molecular Genetics of Sporadic and Familial Renal Cell Carcinoma Urologic Clinics of North America. 20: 33-44. DOI: 10.1007/978-1-4613-1101-0_3  0.425
2000 Paweletz CP, Gillespie JW, Ornstein DK, Simone NL, Brown MR, Cole KA, Wang QH, Huang J, Hu N, Yip TT, Rich WE, Kohn EC, Linehan WM, Weber T, Taylor P, et al. Rapid protein display profiling of cancer progression directly from human tissue using a protein biochip Drug Development Research. 49: 34-42. DOI: 10.1002/(Sici)1098-2299(200001)49:1<34::Aid-Ddr6>3.0.Co;2-W  0.337
1999 Schmidt L, Lubensky I, Linehan WM, Zbard B. Hereditary papillary renal carcinoma: Pathology and pathogenesis Contributions to Nephrology. 128: 11-27. PMID 10597374 DOI: 10.1159/000059982  0.309
1999 Walther MM, Herring J, Enquist E, Keiser HR, Linehan WM, Marston Linehan W. Von Recklinghausen's disease and pheochromocytomas Journal of Urology. 162: 1582-1586. PMID 10524872 DOI: 10.1016/S0022-5347(05)68171-2  0.319
1999 Zambrano NR, Lubensky IA, Merino MJ, Linehan WM, Walther MM. Histopathology and molecular genetics of renal tumors: Toward unification of a classification system Journal of Urology. 162: 1246-1258. PMID 10492174 DOI: 10.1016/S0022-5347(05)68259-6  0.476
1999 Abati A, Sanjuan X, Wilder A, Linehan WM, Hewitt SM, Merino MJ. Utilization of microdissection and the polymerase chain reaction for the diagnosis of adrenal cortical carcinoma in fine-needle aspiration cytology. Cancer. 87: 231-7. PMID 10455212 DOI: 10.1002/(Sici)1097-0142(19990825)87:4<231::Aid-Cncr11>3.0.Co;2-A  0.313
1999 Koochekpour S, Jeffers M, Wang PH, Gong C, Taylor GA, Roessler LM, Stearman R, Vasselli JR, Stetler-Stevenson WG, Kaelin WG, Linehan WM, Klausner RD, Gnarra JR, Vande Woude GF. The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells. Molecular and Cellular Biology. 19: 5902-12. PMID 10454537 DOI: 10.1128/Mcb.19.9.5902  0.424
1999 Lubensky IA, Schmidt L, Zhuang Z, Weirich G, Pack S, Zambrano N, Walther MM, Choyke P, Linehan WM, Zbar B. Hereditary and sporadic papillary renal carcinomas with c-met mutations share a distinct morphological phenotype. The American Journal of Pathology. 155: 517-26. PMID 10433944 DOI: 10.1016/S0002-9440(10)65147-4  0.478
1999 Linehan WM. This month in investigative urology. Kidney cancer: novel model for cancer genetics and therapy The Journal of Urology. 162: 291-292. PMID 10411024 DOI: 10.1016/S0022-5347(05)68542-4  0.355
1999 Gamelin E, Mertins SD, Regis JT, Mickley L, Abati A, Worrell RA, Linehan WM, Bates SE. Intrinsic drug resistance in primary and metastatic renal cell carcinoma. The Journal of Urology. 162: 217-24. PMID 10379790 DOI: 10.1097/00005392-199907000-00071  0.359
1999 Wagner JR, Walther MM, Linehan WM, White DE, Rosenberg SA, Yang JC. Interleukin-2 based immunotherapy for metastatic renal cell carcinoma with the kidney in place. The Journal of Urology. 162: 43-5. PMID 10379736 DOI: 10.1097/00005392-199907000-00011  0.451
1999 Schmidt L, Junker K, Nakaigawa N, Kinjerski T, Weirich G, Miller M, Lubensky I, Neumann HP, Brauch H, Decker J, Vocke C, Brown JA, Jenkins R, Richard S, Bergerheim U, ... ... Linehan WM, et al. Novel mutations of the MET proto-oncogene in papillary renal carcinomas Oncogene. 18: 2343-2350. PMID 10327054 DOI: 10.1038/Sj.Onc.1202547  0.414
1999 Walther MM, Choyke PL, Glenn G, Lyne JC, Rayford W, Venzon D, Linehan WM. Renal cancer in families with hereditary renal cancer: Prospective analysis of a tumor size threshold for renal parenchymal sparing surgery Journal of Urology. 161: 1475-1479. PMID 10210376 DOI: 10.1016/S0022-5347(05)68930-6  0.482
1999 Walther MM, Lyne JC, Libutti SK, Linehan WM. Laparoscopic cytoreductive nephrectomy as preparation for administration of systemic interleukin-2 in the treatment of metastatic renal cell carcinoma: A pilot study Urology. 53: 496-501. PMID 10096373 DOI: 10.1016/S0090-4295(98)00562-7  0.412
1999 Cook J, Krishnan S, Ananth S, Sells SF, Shi Y, Walther MM, Linehan WM, Sukhatme VP, Weinstein MH, Rangnekar VM. Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma. Oncogene. 18: 1205-8. PMID 10022126 DOI: 10.1038/Sj.Onc.1202416  0.318
1999 Rayford W, Lai HH, Middleton LP, Marino MJ, Walther MM, Young J, Linehan WM. DECREASED EXPRESSION OF p27KIP1 IS ASSOCIATED WITH DECREASED SURVIVAL IN PATIENTS WITH METASTATIC RENAL CELL CARCINOMA The Journal of Urology. 196. DOI: 10.1097/00005392-199904010-00786  0.423
1999 Wagner JR, Rosenberg SA, Yang JC, Linehan WM, Walther MM. Il-2 Based Immunotherapy For Metastatic Renal Cell Carcinoma With Kidney In Place The Journal of Urology. 166. DOI: 10.1097/00005392-199904010-00668  0.407
1999 Phillips JL, Ghadimi BM, Wangsa D, Klausner RD, Linehan WM, Ried T. Spectral Karyotyping (SKY) Of Early Clear Cell Carcinomas In Patients With Von Hippel Lindau (VHL) Disease The Journal of Urology. 145. DOI: 10.1097/00005392-199904010-00583  0.349
1999 Walther MM, Lubensky I, Venzon D, Zbar B, Linehan WM. Prevalence Of Microscopic Tumors In Normal Renal Parenchyma From Patients With Renal Cancer Associated With Hereditary Papillary Renal Cancer Syndrome: Clinical And Genetic Implications The Journal of Urology. 139. DOI: 10.1097/00005392-199904010-00560  0.482
1999 Walther MM, Shawker T, Choyke PL, Libutti S, Linehan WM. A Phase Ii Trial To Evaluate Radiofrequency Interstitial Tissue Ablation (Rita) For The Treatment Of Renal Cancer The Journal of Urology. 1. DOI: 10.1097/00005392-199904010-00006  0.363
1998 Libutti SK, Choyke PL, Bartlett DL, Vargas H, Walther M, Lubensky I, Glenn G, Linehan WM, Alexander HR. Pancreatic neuroendocrine tumors associated with von Hippel Lindau disease: Diagnostic and management recommendations Surgery. 124: 1153-1159. PMID 9854597 DOI: 10.1067/Msy.1998.91823  0.335
1998 Stolle C, Glenn G, Zbar B, Humphrey JS, Choyke P, Walther M, Pack S, Hurley K, Andrey C, Klausner R, Linehan WM. Improved detection of germline mutations in the von Hippel-Lindau disease tumor suppressor gene. Human Mutation. 12: 417-23. PMID 9829911 DOI: 10.1002/(Sici)1098-1004(1998)12:6<417::Aid-Humu8>3.0.Co;2-K  0.311
1998 Weirich G, Glenn G, Junker K, Merino M, Störkel S, Lubensky I, Choyke P, Pack S, Amin M, Walther MM, Linehan WM, Zbar B. Familial renal oncocytoma: clinicopathological study of 5 families. The Journal of Urology. 160: 335-40. PMID 9679872 DOI: 10.1016/S0022-5347(01)62888-X  0.386
1998 Lubensky IA, Pack S, Ault D, Vortmeyer AO, Libutti SK, Choyke PL, Walther MM, Linehan WM, Zhuang Z. Multiple neuroendocrine tumors of the pancreas in von Hippel-Lindau disease patients: histopathological and molecular genetic analysis. The American Journal of Pathology. 153: 223-31. PMID 9665483 DOI: 10.1016/S0002-9440(10)65563-0  0.36
1998 Kshirsagar AV, Choyke PL, Linehan WM, Walther MM. Pseudotumors after renal parenchymal sparing surgery Journal of Urology. 159: 1148-1151. PMID 9507819 DOI: 10.1016/S0022-5347(01)63534-1  0.452
1998 Cheng L, Song SY, Pretlow TG, Abdul-Karim FW, Kung HJ, Dawson DV, Park WS, Moon YW, Tsai ML, Linehan WM, Emmert-Buck MR, Liotta LA, Zhuang Z. Evidence of independent origin of multiple tumors from patients with prostate cancer. Journal of the National Cancer Institute. 90: 233-7. PMID 9462681 DOI: 10.1093/Jnci/90.3.233  0.351
1997 Wagner JR, Merino MJ, Pass HI, Linehan WM, Walther MM. Pulmonary infarcts can mimic pulmonary metastases from renal cancer Journal of Urology. 158: 1688-1690. PMID 9334579 DOI: 10.1016/S0022-5347(01)64096-5  0.429
1997 Walther MM, Yang JC, Pass HI, Linehan WM, Rosenberg SA. Cytoreductive surgery before high dose interleukin-2 based therapy in patients with metastatic renal cell carcinoma Journal of Urology. 158: 1675-1678. PMID 9334576 DOI: 10.1016/S0022-5347(01)64091-6  0.403
1997 Choyke PL, Walther MM, Glenn GM, Wagner JR, Venzon DJ, Lubensky IA, Zbar B, Linehan WM. Imaging features of hereditary papillary renal cancers. Journal of Computer Assisted Tomography. 21: 737-41. PMID 9294565 DOI: 10.1097/00004728-199709000-00014  0.396
1997 Gnarra JR, Ward JM, Porter FD, Wagner JR, Devor DE, Grinberg A, Emmert-Buck MR, Westphal H, Klausner RD, Linehan WM. Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 94: 9102-7. PMID 9256442 DOI: 10.1073/Pnas.94.17.9102  0.323
1997 Walther MM, Kleiner DE, Lubensky IA, Pozzatti R, Nyguen T, Gnarra JR, Hurley K, Venzon D, Linehan WM, Stetler-Stevenson WG. Progelatinase A mRNA expression in cell lines derived from tumors in patients with metastatic renal cell carcinoma correlates inversely with survival. Urology. 50: 295-301. PMID 9255309 DOI: 10.1016/S0090-4295(97)00220-3  0.411
1997 Pause A, Lee S, Worrell RA, Chen DY, Burgess WH, Linehan WM, Klausner RD. The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. Proceedings of the National Academy of Sciences of the United States of America. 94: 2156-61. PMID 9122164 DOI: 10.1073/Pnas.94.6.2156  0.375
1997 Walther MM, Patel B, Choyke PL, Lubensky IA, Vocke CD, Harris C, Venzon D, Burtis WJ, Linehan WM. Hypercalcemia in Patients With Metastatic Renal Cell Carcinoma: Effect of Nephrectomy and Metabolic Evaluation Journal of Urology. 158: 733-739. DOI: 10.1016/S0022-5347(01)64303-9  0.474
1997 Beaty MW, Zhuang Z, Park WS, Emmert-Buck MR, Linehan WM, Lubensky IA, Abati A. Fine-needle aspiration of metastatic clear cell carcinoma of the kidney Cancer. 81: 180-186. DOI: 10.1002/(Sici)1097-0142(19970625)81:3<180::Aid-Cncr8>3.0.Co;2-V  0.422
1996 Humphrey JS, Klausner RD, Linehan WM. Von Hippel-Lindau syndrome: hereditary cancer arising from inherited mutations of the VHL tumor suppressor gene. Cancer Treatment and Research. 88: 13-39. PMID 9239471 DOI: 10.1007/978-1-4615-6343-3_2  0.422
1996 Pause A, Aso T, Linehan WM, Conaway JW, Conaway RC, Klausner RD. Interaction of von Hippel-Lindau tumor suppressor gene product with elongin. Methods in Enzymology. 274: 436-41. PMID 8902823 DOI: 10.1016/S0076-6879(96)74035-1  0.613
1996 Sidhar SK, Clark J, Gill S, Hamoudi R, Crew AJ, Gwilliam R, Ross M, Linehan WM, Birdsall S, Shipley J, Cooper CS. The t(X;1)(p11.2;q21.2) translocation in papillary renal sell carcinoma fuses a novel gene PRCC to the TFE3 transcription factor gene Human Molecular Genetics. 5: 1333-1338. PMID 8872474 DOI: 10.1093/Hmg/5.9.1333  0.358
1996 Zbar B, Linehan WM. Re: Hereditary papillary renal cell carcinoma: clinical studies in 10 families The Journal of Urology. 156: 1781. PMID 8863608 DOI: 10.1016/S0022-5347(01)65520-4  0.447
1996 Walther MM, Jennings SB, Choyke PL, Andrich M, Hurley K, Linehan WM, Rosenberg SA, Alexander RB. Isolated perfusion of the kidney with tumor necrosis factor for localized renal-cell carcinoma. World Journal of Urology. S2-7. PMID 8738402 DOI: 10.1007/BF00182056  0.355
1996 Zhuang Z, Emmert-Buck MR, Roth MJ, Gnarra J, Linehan WM, Liotta LA, Lubensky IA. von Hippel-Lindau disease gene deletion detected in microdissected sporadic human colon carcinoma specimens. Human Pathology. 27: 152-6. PMID 8617456 DOI: 10.1016/S0046-8177(96)90368-8  0.376
1996 Gnarra JR, Duan DR, Weng Y, Humphrey JS, Chen DY, Lee S, Pause A, Dudley CF, Latif F, Kuzmin I, Schmidt L, Duh FM, Stackhouse T, Chen F, Kishida T, ... ... Linehan WM, et al. Molecular cloning of the von Hippel-Lindau tumor suppressor gene and its role in renal carcinoma. Biochimica Et Biophysica Acta. 1242: 201-10. PMID 8603073 DOI: 10.1016/0304-419X(95)00012-5  0.451
1996 Talar-Williams C, Hijazi YM, Walther MM, Linehan WM, Hallahan CW, Lubensky I, Kerr GS, Hoffman GS, Fauci AS, Sneller MC. Cyclophosphamide-induced cystitis and bladder cancer in patients with Wegener granulomatosis. Annals of Internal Medicine. 124: 477-84. PMID 8602705 DOI: 10.7326/0003-4819-124-5-199603010-00003  0.328
1996 Giordano TJ, Medeiros LJ, Monterroso V, Linehan WM, Merino MJ. Transthyretin (Prealbumin) Immunoreactivity in Renal Cell Carcinoma and Other Neoplasms International Journal of Surgical Pathology. 4: 1-7. DOI: 10.1177/106689699600400101  0.458
1996 Zbar B, Tory K, Merino M, Schmidt L, Glenn G, Choyke P, Walther MM, Lerman M, Linehan WM, Magnusson G, Bergerheim USR, Pettersson S, Amin M, Hurley K, Linehan WM. Re: Hereditary Papillary Renal Cell Carcinoma; Re The Journal of Urology. 1781. DOI: 10.1097/00005392-199611000-00076  0.431
1996 Wather MM, Linehan WM. Re: Nephron Sparing Surgery for Renal Cell Carcinoma in Von Hippel-Lindau Disease Journal of Urology. 156: 480-481. DOI: 10.1016/S0022-5347(01)65891-9  0.414
1995 Poston CD, Jaffe GS, Lubensky IA, Solomon D, Zbar B, Linehan WM, Walther MM. Characterization of the Renal Pathology of a Familial Form of Renal Cell Carcinoma Associated With Von Hippel-Lindau Disease: Clinical and Molecular Genetic Implications The Journal of Urology. 153: 22-26. PMID 7966777 DOI: 10.1097/00005392-199501000-00009  0.435
1995 Walther MM, Anglard P, Gnarra J, Pozzatti R, Venzon D, De La Rosa A, Macdonald NJ, Steeg PS, Linehan WM. Expression of NM23 in Cell Lines Derived from Patients with Metastatic Renal Cell Carcinoma The Journal of Urology. 154: 278-282. PMID 7776445 DOI: 10.1016/S0022-5347(01)67294-X  0.427
1995 Duan DR, Pause A, Burgess WH, Aso T, Chen DY, Garrett KP, Conaway RC, Conaway JW, Linehan WM, Klausner RD. Inhibition of transcription elongation by the VHL tumor suppressor protein. Science (New York, N.Y.). 269: 1402-6. PMID 7660122 DOI: 10.1126/Science.7660122  0.533
1995 Walther MM, Lubensky IA, Venzon D, Zbar B, Linehan WM. Prevalence of Microscopic lesions in Grossly Normal Renal Parenchyma from Patients with von Hippel-Lindau Disease, Sporadic Renal Cell Carcinoma and No Renal Disease: Clinical Implications The Journal of Urology. 154: 2010-2015. PMID 7500446 DOI: 10.1016/S0022-5347(01)66674-6  0.473
1995 Zbar B, Glenn G, Lubensky I, Choyke P, Walther MM, Magnusson G, Bergerheim USR, Pettersson S, Amin M, Hurley K, Linehan WM. Original Articles: Kidney Cancer The Journal of Urology. 907-912. DOI: 10.1097/00005392-199503001-00005  0.373
1995 Jennings SB, Gnarra JR, Walther MM, Zbar B, Linehan WM. Renal Cell Carcinoma Surgical Oncology Clinics of North America. 4: 219-229. DOI: 10.1016/S1055-3207(18)30449-6  0.474
1995 Walther MM, Choyke PL, Weiss G, Manolatos C, Long J, Reiter R, Alexander RB, Linehan WM. Original Articles: Kidney Cancer: Parenchymal Sparing Surgery in Patients With Hereditary Renal Cell Carcinoma Journal of Urology. 153: 913-916. DOI: 10.1016/S0022-5347(01)67602-X  0.473
1995 Zbar B, Glenn G, Lubensky I, Choyke P, Walther MM, Magnusson G, Bergerheim USR, Pettersson S, Amin M, Hurley K, Linehan WM. Original Articles: Kidney Cancer: Hereditary Papillary Renal Cell Carcinoma: Clinical Studies in 10 Families The Journal of Urology. 153: 907-912. DOI: 10.1016/S0022-5347(01)67601-8  0.442
1995 Zhao W, Gnarra J, Liu S, Knutsen T, Linehan W, Whang-Peng J. Renal cell carcinoma Cancer Genetics and Cytogenetics. 82: 128-139. DOI: 10.1016/0165-4608(95)00024-J  0.326
1994 Zbar B, Tory K, Merino M, Schmidt L, Glenn G, Choyke P, Walther MM, Lerman M, Linehan WM. Hereditary papillary renal cell carcinoma. The Journal of Urology. 151: 561-6. PMID 8308957 DOI: 10.1016/S0022-5347(17)35015-2  0.471
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