Lan Guan, MD, PhD - Publications

Affiliations: 
2008- Cell Physiology and Molecular Biophysics Texas Tech University Health Sciences Center 
Area:
membrane transport and structure biology

104 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Ehsan M, Wang H, Cecchetti C, Mortensen JS, Du Y, Hariharan P, Nygaard A, Lee HJ, Ghani L, Guan L, Loland CJ, Byrne B, Kobilka BK, Chae PS. Maltose-bis(hydroxymethyl)phenol (MBPs) and Maltose-tris(hydroxymethyl)phenol (MTPs) Amphiphiles for Membrane Protein Stability. Acs Chemical Biology. PMID 34445864 DOI: 10.1021/acschembio.1c00578  1
2021 Markham KJ, Tikhonova EB, Scarpa AC, Hariharan P, Katsube S, Guan L. Complete cysteine-scanning mutagenesis of the Salmonella typhimurium melibiose permease. The Journal of Biological Chemistry. 101090. PMID 34416232 DOI: 10.1016/j.jbc.2021.101090  1
2021 Guan L, Hariharan P. X-ray crystallography reveals molecular recognition mechanism for sugar binding in a melibiose transporter MelB. Communications Biology. 4: 931. PMID 34341464 DOI: 10.1038/s42003-021-02462-x  1
2021 Zhao B, Yang F, Guan L, Li X, Hu Y, Zhang C, Liu Y, Li X, Wen W, Lyu H. Fast Independent Component Analysis Algorithm-Based Diagnosis of L5 Nerve Root Compression and Changes of Brain Functional Areas Using 3D Functional Magnetic Resonance Imaging. Journal of Healthcare Engineering. 2021: 5063021. PMID 34336154 DOI: 10.1155/2021/5063021  1
2021 Hariharan P, Guan L. Cooperative binding ensures the obligatory melibiose/Na+ cotransport in MelB. The Journal of General Physiology. 153. PMID 34110360 DOI: 10.1085/jgp.202012710  1
2021 Sadaf A, Kim S, Bae HE, Wang H, Nygaard A, Uegaki Y, Du Y, Munk CF, Katsube S, Bae J, Choi CW, Choi HJ, Byrne B, Gellman SH, Guan L, et al. Conformationally flexible core-bearing detergents with a hydrophobic or hydrophilic pendant: Effect of pendant polarity on detergent conformation and membrane protein stability. Acta Biomaterialia. PMID 33933694 DOI: 10.1016/j.actbio.2021.04.043  1
2021 Liu J, Guan L, Wang E, Schuchman EH, He X, Zeng M. SiO stimulates macrophage stress to induce the transformation of lung fibroblasts into myofibroblasts and its relationship with the sphingomyelin metabolic pathway. Journal of Applied Toxicology : Jat. PMID 33559204 DOI: 10.1002/jat.4148  1
2020 Das M, Mahler F, Hariharan P, Wang H, Du Y, Mortensen JS, Patallo EP, Ghani L, Glück D, Lee HJ, Byrne B, Loland CJ, Guan L, Kobilka BK, Keller S, et al. Diastereomeric Cyclopentane-Based Maltosides (CPMs) as Tools for Membrane Protein Study. Journal of the American Chemical Society. PMID 33315387 DOI: 10.1021/jacs.0c09629  1
2020 Bae HE, Cecchetti C, Du Y, Katsube S, Mortensen JS, Huang W, Rehan S, Lee HJ, Loland CJ, Guan L, Kobilka BK, Byrne B, Chae PS. Pendant-bearing glucose-neopentyl glycol (P-GNG) amphiphiles for membrane protein manipulation: Importance of detergent pendant chain for protein stabilization. Acta Biomaterialia. PMID 32522715 DOI: 10.1016/J.Actbio.2020.06.001  1
2020 Ehsan M, Katsube S, Cecchetti C, Du Y, Mortensen JS, Wang H, Nygaard A, Ghani L, Loland CJ, Kobilka BK, Byrne B, Guan L, Chae PS. New Malonate-Derived Tetraglucoside Detergents for Membrane Protein Stability. Acs Chemical Biology. PMID 32501004 DOI: 10.1021/Acschembio.0C00316  1
2020 Parameswaran H, Guan L. Cooperative Substrate Binding Converges to the Closed Conformations in the Sodium-Coupled Melibiose Symporter MelB Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.2471  1
2019 Ghani L, Munk CF, Zhang X, Katsube S, Du Y, Cecchetti C, Huang W, Bae HE, Saouros S, Ehsan M, Guan L, Liu X, Loland CJ, Kobilka BK, Byrne B, et al. 1,3,5-Triazine-Cored Maltoside Amphiphiles for Membrane Protein Extraction and Stabilization. Journal of the American Chemical Society. PMID 31809039 DOI: 10.1021/Jacs.9B07883  1
2019 Tilegenova C, Cortes DM, Jahovic N, Hardy E, Hariharan P, Guan L, Cuello LG. Structure, function, and ion-binding properties of a K channel stabilized in the 2,4-ion-bound configuration. Proceedings of the National Academy of Sciences of the United States of America. PMID 31387976 DOI: 10.1073/Pnas.1901888116  1
2019 Sadaf A, Ramos M, Mortensen JS, Du Y, Bae HE, Munk CF, Hariharan P, Byrne B, Kobilka BK, Loland CJ, Guan L, Chae PS. Conformationally restricted monosaccharide-cored glycoside amphiphiles: the effect of detergent head group variation on membrane protein stability. Acs Chemical Biology. PMID 31305987 DOI: 10.1021/Acschembio.9B00166  1
2019 Chae PS, Ehsan M, Du Y, Mortensen JS, Hariharan P, Qu Q, Ghani L, Das M, Grethen A, Byrne B, Skiniotis G, Keller S, Loland CJ, Guan L, Kobilka BK. Self-assembly behaviors and application of terphenyl-cored trimaltosides for membrane protein study: Impact of detergent hydrophobic group geometry on protein stability. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 31243822 DOI: 10.1002/Chem.201902468  1
2019 Deng Y, Dai H, Zeng M, Guan L, Luo X, Zhang C, Tian J, Zhang J, Li Y, Xi Q, Zhao M, Jiang M, Zhao L. Knowledge and behavior regarding pesticide use: a survey among caregivers of children aged 1-6 years from rural China. Environmental Science and Pollution Research International. PMID 31183757 DOI: 10.1007/s11356-019-05560-w  1
2019 Kaback HR, Guan L. It takes two to tango: The dance of the permease. The Journal of General Physiology. PMID 31147449 DOI: 10.1085/Jgp.201912377  1
2019 Das M, Du Y, Mortensen JS, Ramos M, Ghani L, Lee HJ, Bae HE, Byrne B, Guan L, Loland CJ, Kobilka BK, Seok Chae P. Correction: Trehalose-cored amphiphiles for membrane protein stabilization: importance of the detergent micelle size in GPCR stability. Organic & Biomolecular Chemistry. PMID 31062815 DOI: 10.1039/c9ob90075f  1
2019 Ehsan M, Kumar A, Mortensen JS, Du Y, Hariharan P, Kumar KK, Ha B, Byrne B, Guan L, Kobilka BK, Loland CJ, Chae PS. Self-Assembly Behaviors of a Penta-Phenylene Maltoside and Its Application for Membrane Protein Study. Chemistry, An Asian Journal. PMID 30969484 DOI: 10.1002/Asia.201900224  1
2019 Das M, Du Y, Mortensen JS, Ramos M, Ghani L, Lee HJ, Bae HE, Byrne B, Guan L, Loland CJ, Kobilka BK, Chae PS. Trehalose-cored amphiphiles for membrane protein stabilization: importance of the detergent micelle size in GPCR stability. Organic & Biomolecular Chemistry. PMID 30843907 DOI: 10.1039/C8Ob03153C  1
2019 Bae HE, Du Y, Hariharan P, Mortensen JS, Kumar KK, Ha B, Das M, Lee HS, Loland CJ, Guan L, Kobilka BK, Chae PS. Asymmetric maltose neopentyl glycol amphiphiles for a membrane protein study: effect of detergent asymmetricity on protein stability. Chemical Science. 10: 1107-1116. PMID 30774908 DOI: 10.1039/C8Sc02560F  1
2018 Hussain H, Helton T, Du Y, Mortensen JS, Hariharan P, Ehsan M, Byrne B, Loland CJ, Kobilka BK, Guan L, Chae PS. A comparative study of branched and linear mannitol-based amphiphiles on membrane protein stability. The Analyst. PMID 30334564 DOI: 10.1039/C8An01408F  1
2018 Hariharan P, Tikhonova E, Medeiros-Silva J, Jeucken A, Bogdanov MV, Dowhan W, Brouwers JF, Weingarth M, Guan L. Structural and functional characterization of protein-lipid interactions of the Salmonella typhimurium melibiose transporter MelB. Bmc Biology. 16: 85. PMID 30075778 DOI: 10.1186/S12915-018-0553-0  1
2018 Chae PS, Das M, Du Y, Mortensen JS, Hariharan P, Byrne B, Loland CJ, Guan L, Kobilka B, Lee HS. Rationally engineered tandem facial amphiphiles for improved membrane protein stabilization efficacy. Chembiochem : a European Journal of Chemical Biology. PMID 30070754 DOI: 10.1002/Cbic.201800388  1
2018 Wang W, Guan L, Seib PA, Shi YC. Settling volume and morphology changes in cross-linked and unmodified starches from wheat, waxy wheat, and waxy maize in relation to their pasting properties. Carbohydrate Polymers. 196: 18-26. PMID 29891286 DOI: 10.1016/J.Carbpol.2018.05.009  1
2018 Chae PS, Ehsan M, Das M, Stern V, Du Y, Mortensen J, Hariharan P, Byrne B, Loland C, Kobilka B, Guan L. Steroid-based amphiphiles for membrane protein study: Importance of alkyl spacer for protein stability. Chembiochem : a European Journal of Chemical Biology. PMID 29660780 DOI: 10.1002/Cbic.201800106  1
2018 Ehsan M, Du Y, Molist I, Seven AB, Hariharan P, Mortensen JS, Ghani L, Loland CJ, Skiniotis G, Guan L, Byrne B, Kobilka BK, Chae PS. Vitamin E-based glycoside amphiphiles for membrane protein structural studies. Organic & Biomolecular Chemistry. PMID 29564464 DOI: 10.1039/C8Ob00270C  1
2018 Parameswaran H, Vemulapally S, Santillan C, Helten T, Tikhonova E, Ramos M, He T, Guan L. Development of Novel Protein-Capture Reagents against Epidermal Growth Factor as Potential Anticancer Agents Biophysical Journal. 114. DOI: 10.1016/J.Bpj.2017.11.996  1
2017 Sadaf A, Du Y, Santillan C, Mortensen JS, Molist I, Seven AB, Hariharan P, Skiniotis G, Loland CJ, Kobilka BK, Guan L, Byrne B, Chae PS. Dendronic trimaltoside amphiphiles (DTMs) for membrane protein study. Chemical Science. 8: 8315-8324. PMID 29619178 DOI: 10.1039/C7Sc03700G  1
2017 Hariharan P, Guan L. Thermodynamic cooperativity of cosubstrate binding and cation selectivity of Salmonella typhimurium MelB. The Journal of General Physiology. PMID 29054867 DOI: 10.1085/Jgp.201711788  1
2017 Ehsan M, Ghani L, Du Y, Hariharan P, Mortensen JS, Ribeiro O, Hu H, Skiniotis G, Loland CJ, Guan L, Kobilka BK, Byrne B, Chae PS. New penta-saccharide-bearing tripod amphiphiles for membrane protein structure studies. The Analyst. PMID 28913526 DOI: 10.1039/C7An01168G  1
2017 Hussain H, Mortensen JS, Du Y, Santillan C, Ribeiro O, Go J, Hariharan P, Loland CJ, Guan L, Kobilka BK, Byrne B, Chae PS. Tandem malonate-based glucosides (TMGs) for membrane protein structural studies. Scientific Reports. 7: 3963. PMID 28638082 DOI: 10.1038/S41598-017-03809-3  1
2017 Das M, Du Y, Mortensen JS, Ribeiro O, Hariharan P, Guan L, Loland CJ, Kobilka BK, Byrne B, Chae PS. Butane-1,2,3,4-tetraol-based amphiphilic stereoisomers for membrane protein study: importance of chirality in the linker region. Chemical Science. 8: 1169-1177. PMID 28451257 DOI: 10.1039/C6Sc02981G  1
2017 Chae PS, Hussain H, Du Y, Tikhonova E, Mortensen J, Ribeiro O, Santillan C, Das M, Løland C, Guan L, Kobilka B, Byrne B, Ehsan M. Resorcinarene-based facial glycosides: implication of detergent flexibility on membrane protein stability. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 28303608 DOI: 10.1002/Chem.201605016  1
2017 Das M, Du Y, Ribeiro O, Hariharan P, Mortensen JS, Patra D, Skiniotis G, Loland CJ, Guan L, Kobilka BK, Byrne B, Chae PS. Conformationally Preorganized Diastereomeric Norbornane-Based Maltosides for Membrane Protein Study: Implications of Detergent Kink for Micellar Properties. Journal of the American Chemical Society. PMID 28218862 DOI: 10.1021/Jacs.6B11997  1
2017 Parameswaran H, Guan L. Insights into the Cation Selectivity and Cooperativity with Sugar in Salmonella Typhimurium Melibiose Permease Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.125  1
2016 Cho KH, Hariharan P, Mortensen JS, Du Y, Nielsen AK, Byrne B, Kobilka BK, Loland CJ, Guan L, Chae PS. Isomeric Detergent Comparison for Membrane Protein Stability: Importance of Inter-Alkyl-Chain Distance and Alkyl Chain Length. Chembiochem : a European Journal of Chemical Biology. 17: 2334-2339. PMID 27981750 DOI: 10.1002/Cbic.201600429  1
2016 Chae PS, Cho KH, Ribeiro O, Du Y, Tikhonova E, Mortensen J, Markham K, Hariharan P, Løland C, Guan L, Kobilka B, Byrne B. Mesitylene-cored glucoside amphiphiles (MGAs) for membrane protein studies: importance of alkyl chain density in detergent efficacy. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27743406 DOI: 10.1002/Chem.201603338  1
2016 Hariharan P, Andersson M, Jiang X, Pardon E, Steyaert J, Kaback HR, Guan L. Thermodynamics of nanobody binding to lactose permease. Biochemistry. PMID 27686537 DOI: 10.1021/Acs.Biochem.6B00826  1
2016 Sadaf A, Mortensen JS, Capaldi S, Tikhonova E, Hariharan P, de Castro Ribeiro O, Loland CJ, Guan L, Byrne B, Chae PS. A Class of Rigid Linker-bearing Glucosides for Membrane Protein Structural Study. Chemical Science (Royal Society of Chemistry : 2010). 7: 1933-1939. PMID 27110345 DOI: 10.1039/C5Sc02900G  1
2016 Ehsan M, Du Y, Scull NJ, Tikhonova E, Tarrasch J, Mortensen JS, Loland CJ, Skiniotis G, Guan L, Byrne B, Kobilka BK, Chae PS. Highly Branched Pentasaccharide-Bearing Amphiphiles for Membrane Protein Studies. Journal of the American Chemical Society. PMID 26966956 DOI: 10.1021/Jacs.5B13233  1
2016 Sadaf A, Mortensen JS, Capaldi S, Tikhonova E, Hariharan P, Ribeiro O, Loland CJ, Guan L, Byrne B, Chae PS. A class of rigid linker-bearing glucosides for membrane protein structural study Chemical Science. 7: 1933-1939. DOI: 10.1039/c5sc02900g  1
2015 Huang MZ, Li J, Guan L, Li DQ, Nie XM, Gui R, Chen X. Therapeutic effects of acetylspiramycin and garlicin on cryptosporidiosis among drug users. International Journal For Parasitology. Drugs and Drug Resistance. 5: 185-190. PMID 27120065 DOI: 10.1016/j.ijpddr.2015.09.002  0.01
2015 Amin A, Hariharan P, Chae PS, Guan L. Effect of Detergents on Galactoside Binding by Melibiose Permeases. Biochemistry. 54: 5849-55. PMID 26352464 DOI: 10.1021/Acs.Biochem.5B00660  1
2015 Cho KH, Du Y, Scull NJ, Hariharan P, Gotfryd K, Loland CJ, Guan L, Byrne B, Kobilka BK, Chae PS. Novel Xylene-Linked Maltoside Amphiphiles (XMAs) for Membrane Protein Stabilisation. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 10008-13. PMID 26013293 DOI: 10.1002/Chem.201501083  1
2015 Cho KH, Husri M, Amin A, Gotfryd K, Lee HJ, Go J, Kim JW, Loland CJ, Guan L, Byrne B, Chae PS. Maltose neopentyl glycol-3 (MNG-3) analogues for membrane protein study. The Analyst. 140: 3157-63. PMID 25813698 DOI: 10.1039/C5An00240K  1
2015 Liu ZW, Wang HY, Guan L, Zhao B. Regulatory effects of hydrogen sulfide on alveolar epithelial cell endoplasmic reticulum stress in rats with acute lung injury. World Journal of Emergency Medicine. 6: 67-73. PMID 25802570 DOI: 10.5847/wjem.j.1920-8642.2015.01.012  1
2015 Hariharan P, Guan L. Insights into the inhibitory mechanisms of the regulatory protein IIAGlc on melibiose permease activity. The Journal of Biological Chemistry. 290: 6752. PMID 25770301 DOI: 10.1074/jbc.A114.609255  1
2015 Hariharan P, Balasubramaniam D, Peterkofsky A, Kaback HR, Guan L. Thermodynamic mechanism for inhibition of lactose permease by the phosphotransferase protein IIAGlc. Proceedings of the National Academy of Sciences of the United States of America. 112: 2407-12. PMID 25675534 DOI: 10.1073/Pnas.1500891112  0.6
2015 Wang Q, Guan L, Li RM, Zhao B. Pulmonary thromboembolism associated with olanzapine treatment. Chinese Medical Journal. 128: 419-20. PMID 25635446 DOI: 10.4103/0366-6999.150124  1
2015 Tikhonova EB, Ethayathulla AS, Su Y, Hariharan P, Xie S, Guan L. A transcription blocker isolated from a designed repeat protein combinatorial library by in vivo functional screen. Scientific Reports. 5: 8070. PMID 25627011 DOI: 10.1038/Srep08070  1
2015 Hariharan P, Guan L. Insights into the inhibitory mechanisms of the regulatory protein IIAGlcon melibiose permease activity Journal of Biological Chemistry. 290: 6752. DOI: 10.1074/jbc.A114.609255  1
2015 Amin A, Hariharan P, Chae PS, Guan L. Effect of Detergents on Galactoside Binding by Melibiose Permeases Biochemistry. 54: 5849-5855. DOI: 10.1021/acs.biochem.5b00660  1
2015 Parmeswaran H, Dhandayuthapani B, Peterkofsky A, Kaback RH, Guan L. Thermodynamic Features of IIAGlc Inhibition of Sugar Symporters Biophysical Journal. 108. DOI: 10.1016/J.Bpj.2014.11.179  0.01
2014 Liu X, Zhong C, Zeng M, Guan L, Xie Y, Xiao F. [Effects of 10% Liuyangmycin emulsifiable on mitochondrial function in L-02 hepatocytes]. Wei Sheng Yan Jiu = Journal of Hygiene Research. 43: 906-10. PMID 25603597  1
2014 Hariharan P, Guan L. Insights into the inhibitory mechanisms of the regulatory protein IIA(Glc) on melibiose permease activity. The Journal of Biological Chemistry. 289: 33012-9. PMID 25296751 DOI: 10.1074/Jbc.M114.609255  1
2014 Amin A, Ethayathulla AS, Guan L. Suppression of conformation-compromised mutants of Salmonella enterica serovar Typhimurium MelB. Journal of Bacteriology. 196: 3134-9. PMID 24957620 DOI: 10.1128/Jb.01868-14  1
2014 Ethayathulla AS, Yousef MS, Amin A, Leblanc G, Kaback HR, Guan L. Structure-based mechanism for Na(+)/melibiose symport by MelB. Nature Communications. 5: 3009. PMID 24389923 DOI: 10.1038/Ncomms4009  1
2014 Tikhonova EB, Parameswaran H, Su Y, Anowarul A, Guan L. Functional Inhibition of Sugar Transport by a Designed Novel Protein Biophysical Journal. 106: 3-7. DOI: 10.1016/J.Bpj.2013.11.2080  1
2014 Amin A, Ethayathulla AS, Guan L. Ionic Locks in Melibiose Permease: Scope towards GLUT1 Deficiency Syndrome Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.2079  1
2013 Chae PS, Kruse AC, Gotfryd K, Rana RR, Cho KH, Rasmussen SG, Bae HE, Chandra R, Gether U, Guan L, Kobilka BK, Loland CJ, Byrne B, Gellman SH. Novel tripod amphiphiles for membrane protein analysis. Chemistry (Weinheim An Der Bergstrasse, Germany). 19: 15645-51. PMID 24123610 DOI: 10.1002/Chem.201301423  1
2013 Zeng M, Xiao F, Zhong X, Jin F, Guan L, Wang A, Liu X, Zhong C. Reactive oxygen species play a central role in hexavalent chromium-induced apoptosis in Hep3B cells without the functional roles of p53 and caspase-3. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 32: 279-90. PMID 23942225 DOI: 10.1159/000354436  1
2013 Xiao F, Chen D, Luo L, Zhong X, Xie Y, Zou L, Zeng M, Guan L, Zhong C. Time‑order effects of vitamin C on hexavalent chromium‑induced mitochondrial damage and DNA‑protein crosslinks in cultured rat peripheral blood lymphocytes. Molecular Medicine Reports. 8: 53-60. PMID 23657841 DOI: 10.3892/mmr.2013.1462  1
2013 Xie Y, Zhong C, Zeng M, Guan L, Luo L. Effect of hexavalent chromium on electron leakage of respiratory chain in mitochondria isolated from rat liver. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 31: 473-85. PMID 23548633 DOI: 10.1159/000350062  1
2012 Guan L, Zhang Z, Zhong C, Liu X, Wang A, Zeng M. [Effects of gibberellins on early development and IGF-1 expression in female rats]. Wei Sheng Yan Jiu = Journal of Hygiene Research. 41: 390-3, 398. PMID 23050434  1
2012 Li P, Zhong C, Wang A, Guan L, Xiao F, Zou Y, Yang Y. [Effect of hOGG1 gene on the oxidative damage of mitochondrial DNA induced by hexavalent chromium]. Wei Sheng Yan Jiu = Journal of Hygiene Research. 41: 385-9. PMID 23050433  1
2012 Xiao F, Feng X, Zeng M, Guan L, Hu Q, Zhong C. Hexavalent chromium induces energy metabolism disturbance and p53-dependent cell cycle arrest via reactive oxygen species in L-02 hepatocytes. Molecular and Cellular Biochemistry. 371: 65-76. PMID 22886373 DOI: 10.1007/s11010-012-1423-7  1
2012 Jakkula SV, Guan L. Reduced Na+ affinity increases turnover of Salmonella enterica serovar Typhimurium MelB. Journal of Bacteriology. 194: 5538-44. PMID 22865849 DOI: 10.1128/Jb.01206-12  1
2012 Chae PS, Rasmussen SG, Rana RR, Gotfryd K, Kruse AC, Manglik A, Cho KH, Nurva S, Gether U, Guan L, Loland CJ, Byrne B, Kobilka BK, Gellman SH. A new class of amphiphiles bearing rigid hydrophobic groups for solubilization and stabilization of membrane proteins. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 9485-90. PMID 22730191 DOI: 10.1002/Chem.201200069  1
2012 Xiao F, Hu Q, Zeng M, Guan L, Liu X, Yang Y, Zhong C. WITHDRAWN: Hexavalent chromium induces premature senescence through reactive oxygen species-mediated p53 pathway in L-02 hepatocytes. Biochemical and Biophysical Research Communications. PMID 22521640 DOI: 10.1016/j.bbrc.2012.04.044  1
2012 Guan L, Jakkula SV, Hodkoff AA, Su Y. Role of Gly117 in the cation/melibiose symport of MelB of Salmonella typhimurium. Biochemistry. 51: 2950-7. PMID 22413840 DOI: 10.1021/Bi300230H  1
2012 Jiang X, Guan L, Zhou Y, Hong WX, Zhang Q, Kaback HR. Evidence for an intermediate conformational state of LacY. Proceedings of the National Academy of Sciences of the United States of America. 109: E698-704. PMID 22355148 DOI: 10.1073/Pnas.1201107109  1
2011 Li M, Li TS, Liu ZW, Guan L, Jin HF, Zhao B, DU JB. [Effects of hydrogen sulfide on the expressions of nuclear factor-κB and intercellular adhesion molecule 1 in pulmonary tissue of rats with acute lung injury]. Zhonghua Yi Xue Za Zhi. 91: 3054-7. PMID 22333058  1
2011 Zhou Y, Madej MG, Guan L, Nie Y, Kaback HR. An early event in the transport mechanism of LacY protein: interaction between helices V and I. The Journal of Biological Chemistry. 286: 30415-22. PMID 21730060 DOI: 10.1074/Jbc.M111.268433  1
2011 Chaptal V, Kwon S, Sawaya MR, Guan L, Kaback HR, Abramson J. Crystal structure of lactose permease in complex with an affinity inactivator yields unique insight into sugar recognition. Proceedings of the National Academy of Sciences of the United States of America. 108: 9361-6. PMID 21593407 DOI: 10.1073/pnas.1105687108  1
2011 Kudugunti SK, Thorsheim H, Yousef MS, Guan L, Moridani MY. The metabolic bioactivation of caffeic acid phenethyl ester (CAPE) mediated by tyrosinase selectively inhibits glutathione S-transferase. Chemico-Biological Interactions. 192: 243-56. PMID 21458432 DOI: 10.1016/J.Cbi.2011.03.015  1
2011 Guan L, Nurva S, Ankeshwarapu SP. Mechanism of melibiose/cation symport of the melibiose permease of Salmonella typhimurium. The Journal of Biological Chemistry. 286: 6367-74. PMID 21148559 DOI: 10.1074/Jbc.M110.206227  0.01
2011 Király O, Guan L, Sahin-Tóth M. Expression of recombinant proteins with uniform N-termini. Methods in Molecular Biology (Clifton, N.J.). 705: 175-94. PMID 21125386 DOI: 10.1007/978-1-61737-967-3_10  1
2010 Deng Y, Zhong C, Guan L, Chen J, Xiao F. [Effect of gibberellin on mitochondria respiratory function of hepatocytes in rats]. Wei Sheng Yan Jiu = Journal of Hygiene Research. 39: 697-700. PMID 21351634  1
2010 Chae PS, Rasmussen SG, Rana RR, Gotfryd K, Chandra R, Goren MA, Kruse AC, Nurva S, Loland CJ, Pierre Y, Drew D, Popot JL, Picot D, Fox BG, Guan L, et al. Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins. Nature Methods. 7: 1003-8. PMID 21037590 DOI: 10.1038/Nmeth.1526  1
2009 Guan L, Kaback HR. Properties of a LacY efflux mutant. Biochemistry. 48: 9250-5. PMID 19719233 DOI: 10.1021/Bi9014067  1
2009 Yousef MS, Guan L. A 3D structure model of the melibiose permease of Escherichia coli represents a distinctive fold for Na+ symporters. Proceedings of the National Academy of Sciences of the United States of America. 106: 15291-6. PMID 19706416 DOI: 10.1073/Pnas.0905516106  1
2009 Guan L, Seib PA, Graybosch RA, Bean S, Shi YC. Dough rheology and wet milling of hard waxy wheat flours. Journal of Agricultural and Food Chemistry. 57: 7030-8. PMID 19594158 DOI: 10.1021/Jf900438V  1
2008 Zhou Y, Guan L, Freites JA, Kaback HR. Opening and closing of the periplasmic gate in lactose permease. Proceedings of the National Academy of Sciences of the United States of America. 105: 3774-8. PMID 18319336 DOI: 10.1073/Pnas.0800825105  1
2007 Guan L, Mirza O, Verner G, Iwata S, Kaback HR. Structural determination of wild-type lactose permease. Proceedings of the National Academy of Sciences of the United States of America. 104: 15294-8. PMID 17881559 DOI: 10.1073/Pnas.0707688104  1
2007 Guan L, Kaback HR. Site-directed alkylation of cysteine to test solvent accessibility of membrane proteins. Nature Protocols. 2: 2012-7. PMID 17703213 DOI: 10.1038/Nprot.2007.275  1
2006 Guan L, Kaback HR. Lessons from lactose permease. Annual Review of Biophysics and Biomolecular Structure. 35: 67-91. PMID 16689628 DOI: 10.1146/Annurev.Biophys.35.040405.102005  1
2006 Király O, Guan L, Szepessy E, Tóth M, Kukor Z, Sahin-Tóth M. Expression of human cationic trypsinogen with an authentic N terminus using intein-mediated splicing in aminopeptidase P deficient Escherichia coli. Protein Expression and Purification. 48: 104-11. PMID 16542853 DOI: 10.1016/J.Pep.2006.01.023  1
2006 Mirza O, Guan L, Verner G, Iwata S, Kaback HR. Structural evidence for induced fit and a mechanism for sugar/H+ symport in LacY. The Embo Journal. 25: 1177-83. PMID 16525509 DOI: 10.1038/Sj.Emboj.7601028  1
2006 Guan L, Smirnova IN, Verner G, Nagamori S, Nagamoni S, Kaback HR. Manipulating phospholipids for crystallization of a membrane transport protein. Proceedings of the National Academy of Sciences of the United States of America. 103: 1723-6. PMID 16446422 DOI: 10.1073/Pnas.0510922103  1
2006 Guan L, Smirnova IN, Verner G, Nagamori S, Kaback HR. Correction for Guan et al., Manipulating phospholipids for crystallization of a membrane transport protein Proceedings of the National Academy of Sciences of the United States of America. 103: 6073-6073. DOI: 10.1073/Pnas.0601039103  1
2004 Vázquez-Ibar JL, Guan L, Weinglass AB, Verner G, Gordillo R, Kaback HR. Sugar recognition by the lactose permease of Escherichia coli. The Journal of Biological Chemistry. 279: 49214-21. PMID 15364943 DOI: 10.1074/jbc.M407408200  1
2004 Guan L, Kaback HR. Binding affinity of lactose permease is not altered by the H+ electrochemical gradient. Proceedings of the National Academy of Sciences of the United States of America. 101: 12148-52. PMID 15304639 DOI: 10.1073/Pnas.0404936101  1
2003 Vázquez-Ibar JL, Guan L, Svrakic M, Kaback HR. Exploiting luminescence spectroscopy to elucidate the interaction between sugar and a tryptophan residue in the lactose permease of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 100: 12706-11. PMID 14566061 DOI: 10.1073/Pnas.1835645100  1
2003 Ermolova N, Guan L, Kaback HR. Intermolecular thiol cross-linking via loops in the lactose permease of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 100: 10187-92. PMID 12934015 DOI: 10.1073/Pnas.1434239100  1
2003 Guan L, Hu Y, Kaback HR. Aromatic stacking in the sugar binding site of the lactose permease. Biochemistry. 42: 1377-82. PMID 12578349 DOI: 10.1021/Bi027152M  1
2003 Guan L, Sahin-Tóth M, Kálai T, Hideg K, Kaback HR. Probing the mechanism of a membrane transport protein with affinity inactivators. The Journal of Biological Chemistry. 278: 10641-8. PMID 12471022 DOI: 10.1074/Jbc.M211355200  1
2002 Sorgen PL, Hu Y, Guan L, Kaback HR, Girvin ME. An approach to membrane protein structure without crystals. Proceedings of the National Academy of Sciences of the United States of America. 99: 14037-40. PMID 12391320 DOI: 10.1073/Pnas.182552199  1
2002 Guan L, Sahin-Toth M, Kaback HR. Changing the lactose permease of Escherichia coli into a galactose-specific symporter. Proceedings of the National Academy of Sciences of the United States of America. 99: 6613-8. PMID 12011425 DOI: 10.1073/Pnas.102178299  1
2002 Guan L, Murphy FD, Kaback HR. Surface-exposed positions in the transmembrane helices of the lactose permease of Escherichia coli determined by intermolecular thiol cross-linking. Proceedings of the National Academy of Sciences of the United States of America. 99: 3475-80. PMID 11904412 DOI: 10.1073/Pnas.052703699  1
2002 Zhang W, Guan L, Kaback HR. Helices VII and X in the lactose permease of Escherichia coli: proximity and ligand-induced distance changes. Journal of Molecular Biology. 315: 53-62. PMID 11771965 DOI: 10.1006/Jmbi.2001.5206  1
2001 Guan L, Weinglass AB, Kaback HR. Helix packing in the lactose permease of Escherichia coli: localization of helix VI. Journal of Molecular Biology. 312: 69-77. PMID 11545586 DOI: 10.1006/Jmbi.2001.4933  1
2001 Guan L, Nakae T. Identification of essential charged residues in transmembrane segments of the multidrug transporter MexB of Pseudomonas aeruginosa Journal of Bacteriology. 183: 1734-1739. PMID 11160105 DOI: 10.1128/Jb.183.5.1734-1739.2001  1
1999 Guan L, Ehrmann M, Yoneyama H, Nakae T. Membrane topology of the xenobiotic-exporting subunit, MexB, of the MexA,B-OprM extrusion pump in Pseudomonas aeruginosa. Journal of Biological Chemistry. 274: 10517-10522. PMID 10187844 DOI: 10.1074/Jbc.274.15.10517  1
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