Faustino Mollinedo - Publications

Biochemistry and Molecular Biology Complutense University of Madrid, Madrid, Comunidad de Madrid, Spain 

134 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Gajate C, Mollinedo F. Lipid Raft Isolation by Sucrose Gradient Centrifugation and Visualization of Raft-Located Proteins by Fluorescence Microscopy: The Use of Combined Techniques to Assess Fas/CD95 Location in Rafts During Apoptosis Triggering. Methods in Molecular Biology (Clifton, N.J.). 2187: 147-186. PMID 32770506 DOI: 10.1007/978-1-0716-0814-2_9  0.335
2020 Sevilla-Movilla S, Arellano-Sánchez N, Martínez-Moreno M, Gajate C, Sánchez-Vencells A, Valcárcel LV, Agirre X, Valeri A, Martínez-López J, Prósper F, Mollinedo F, Teixidó J. Upregulated expression and function of the α4β1 integrin in multiple myeloma cells resistant to bortezomib. The Journal of Pathology. 252: 29-40. PMID 32501543 DOI: 10.1002/Path.5480  0.325
2020 Álvarez R, Aramburu L, Gajate C, Vicente-Blázquez A, Mollinedo F, Medarde M, Peláez R. Potent colchicine-site ligands with improved intrinsic solubility by replacement of the 3,4,5-trimethoxyphenyl ring with a 2-methylsulfanyl-6-methoxypyridine ring. Bioorganic Chemistry. 98: 103755. PMID 32200330 DOI: 10.1016/J.Bioorg.2020.103755  0.343
2020 Mollinedo F, Gajate C. Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapy. Journal of Lipid Research. PMID 31988146 DOI: 10.1194/Jlr.Tr119000439  0.358
2019 Mollinedo F, Gajate C. Novel therapeutic approaches for pancreatic cancer by combined targeting of RAF→MEK→ERK signaling and autophagy survival response. Annals of Translational Medicine. 7: S153. PMID 31576360 DOI: 10.21037/Atm.2019.06.40  0.323
2019 Mollinedo F. Neutrophil Degranulation, Plasticity, and Cancer Metastasis. Trends in Immunology. 40: 228-242. PMID 30777721 DOI: 10.1016/J.It.2019.01.006  0.306
2018 Álvarez R, Gajate C, Puebla P, Mollinedo F, Medarde M, Peláez R. Substitution at the indole 3 position yields highly potent indolecombretastatins against human tumor cells. European Journal of Medicinal Chemistry. 158: 167-183. PMID 30216850 DOI: 10.1016/J.Ejmech.2018.08.078  0.392
2018 Bello C, Bai J, Zambron BK, Elías-Rodríguez P, Gajate C, Robina I, Caffa I, Cea M, Montecucco F, Nencioni A, Nahimana A, Aubry D, Breton C, Duchosal MA, Mollinedo F, et al. Induction of cell killing and autophagy by amphiphilic pyrrolidine derivatives on human pancreatic cancer cells. European Journal of Medicinal Chemistry. 150: 457-478. PMID 29547833 DOI: 10.1016/J.Ejmech.2018.02.086  0.393
2017 Conde-Rioll M, Gajate C, Fernández JJ, Villa-Pulgarin JA, Napolitano JG, Norte M, Mollinedo F. Antitumor activity of Lepidium latifolium and identification of the epithionitrile 1-cyano-2,3-epithiopropane as its major active component. Molecular Carcinogenesis. PMID 29073716 DOI: 10.1002/Mc.22759  0.393
2017 Gajate C, Mollinedo F. Isolation of Lipid Rafts Through Discontinuous Sucrose Gradient Centrifugation and Fas/CD95 Death Receptor Localization in Raft Fractions. Methods in Molecular Biology (Clifton, N.J.). 1557: 125-138. PMID 28078589 DOI: 10.1007/978-1-4939-6780-3_13  0.335
2017 González-Fernández Y, Imbuluzqueta E, Zalacain M, Mollinedo F, Patiño-García A, Blanco-Prieto MJ. Doxorubicin and edelfosine lipid nanoparticles are effective acting synergistically against drug-resistant osteosarcoma cancer cells. Cancer Letters. 388: 262-268. PMID 27998763 DOI: 10.1016/J.Canlet.2016.12.012  0.334
2016 Legarda-Ceballos AL, Rojas-Caraballo J, López-Abán J, Ruano AL, Yepes E, Gajate C, Mollinedo F, Muro A. The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell death. Acta Tropica. PMID 27394030 DOI: 10.1016/J.Actatropica.2016.07.001  0.346
2016 Jaffrès PA, Gajate C, Bouchet AM, Couthon-Gourvès H, Chantôme A, Potier-Cartereau M, Besson P, Bougnoux P, Mollinedo F, Vandier C. Alkyl ether lipids, ion channels and lipid raft reorganization in cancer therapy. Pharmacology & Therapeutics. 165: 114-31. PMID 27288726 DOI: 10.1016/J.Pharmthera.2016.06.003  0.358
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Mollinedo F, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356  0.301
2015 Gil-Mesón A, Roncero AM, Tobal IE, Basabe P, Díez D, Mollinedo F, Marcos IS. Synthesis of Bioconjugate Sesterterpenoids with Phospholipids and Polyunsaturated Fatty Acids. Molecules (Basel, Switzerland). 21: E47. PMID 26729084 DOI: 10.3390/Molecules21010047  0.323
2015 Gajate C, Mollinedo F. Lipid raft-mediated Fas/CD95 apoptotic signaling in leukemic cells and normal leukocytes and therapeutic implications. Journal of Leukocyte Biology. 98: 739-59. PMID 26246489 DOI: 10.1189/Jlb.2Mr0215-055R  0.388
2015 Bonilla X, Dakir el-H, Mollinedo F, Gajate C. Endoplasmic reticulum targeting in Ewing's sarcoma by the alkylphospholipid analog edelfosine. Oncotarget. 6: 14596-613. PMID 25999349 DOI: 10.18632/Oncotarget.4053  0.375
2015 Melo-Lima S, Lopes MC, Mollinedo F. ERK1/2 acts as a switch between necrotic and apoptotic cell death in ether phospholipid edelfosine-treated glioblastoma cells. Pharmacological Research. 95: 2-11. PMID 25749008 DOI: 10.1016/J.Phrs.2015.02.007  0.391
2015 Gajate C, Mollinedo F. Lipid rafts and raft-mediated supramolecular entities in the regulation of CD95 death receptor apoptotic signaling. Apoptosis : An International Journal On Programmed Cell Death. 20: 584-606. PMID 25702154 DOI: 10.1007/S10495-015-1104-6  0.352
2015 Melo-Lima S, Gajate C, Mollinedo F. Triggers and signaling cross-talk controlling cell death commitment. Cell Cycle (Georgetown, Tex.). 14: 465-6. PMID 25590143 DOI: 10.1080/15384101.2015.1006540  0.416
2015 Mollinedo F, Gajate C. Lipid rafts as major platforms for signaling regulation in cancer. Advances in Biological Regulation. 57: 130-46. PMID 25465296 DOI: 10.1016/J.Jbior.2014.10.003  0.37
2014 Sánchez-Blanco A, Rodríguez-Matellán AG, Reis-Sobreiro M, Sáenz-Narciso B, Cabello J, Mohler WA, Mollinedo F. Caenorhabditis elegans as a platform to study the mechanism of action of synthetic antitumor lipids. Cell Cycle (Georgetown, Tex.). 13: 3375-89. PMID 25485582 DOI: 10.4161/15384101.2014.952183  0.358
2014 Gajate C, Mollinedo F. Lipid rafts, endoplasmic reticulum and mitochondria in the antitumor action of the alkylphospholipid analog edelfosine. Anti-Cancer Agents in Medicinal Chemistry. 14: 509-27. PMID 24628241 DOI: 10.2174/1871520614666140309222259  0.403
2014 Mollinedo F. Editorial: Antitumor alkylphospholipid analogs: a promising and growing family of synthetic cell membrane-targeting molecules for cancer treatment). Anti-Cancer Agents in Medicinal Chemistry. 14: 495-8. PMID 24628231 DOI: 10.2174/1871520614999140313160011  0.311
2014 Marcos IS, Moro RF, Costales I, Basabe P, Díez D, Gil A, Mollinedo F, Pérez-de la Rosa F, Pérez-Roth E, Padrón JM. Synthesis and biological activity of polyalthenol and pentacyclindole analogues. European Journal of Medicinal Chemistry. 73: 265-79. PMID 24412720 DOI: 10.1016/J.Ejmech.2013.12.012  0.343
2014 Varela-M RE, Mollinedo-Gajate C, Muro A, Mollinedo F. The HSP90 inhibitor 17-AAG potentiates the antileishmanial activity of the ether lipid edelfosine. Acta Tropica. 131: 32-6. PMID 24299925 DOI: 10.1016/J.Actatropica.2013.11.018  0.343
2013 Castro BM, Fedorov A, Hornillos V, Delgado J, Acuña AU, Mollinedo F, Prieto M. Edelfosine and miltefosine effects on lipid raft properties: membrane biophysics in cell death by antitumor lipids. The Journal of Physical Chemistry. B. 117: 7929-40. PMID 23738749 DOI: 10.1021/Jp401407D  0.339
2013 Reis-Sobreiro M, Roué G, Moros A, Gajate C, Iglesia-Vicente Jdl, Colomer D, Mollinedo F. Lipid raft-mediated Akt signaling as a therapeutic target in mantle cell lymphoma Blood Cancer Journal. 3. PMID 23727661 DOI: 10.1038/Bcj.2013.15  0.404
2013 Burgeiro A, Bento AC, Gajate C, Oliveira PJ, Mollinedo F. Rapid human melanoma cell death induced by sanguinarine through oxidative stress. European Journal of Pharmacology. 705: 109-18. PMID 23499690 DOI: 10.1016/J.Ejphar.2013.02.035  0.378
2013 Álvarez R, Puebla P, Díaz JF, Bento AC, García-Navas R, de la Iglesia-Vicente J, Mollinedo F, Andreu JM, Medarde M, Peláez R. Endowing indole-based tubulin inhibitors with an anchor for derivatization: highly potent 3-substituted indolephenstatins and indoleisocombretastatins. Journal of Medicinal Chemistry. 56: 2813-27. PMID 23470139 DOI: 10.1021/Jm3015603  0.353
2013 Czyz O, Bitew T, Cuesta-Marbán A, McMaster CR, Mollinedo F, Zaremberg V. Alteration of plasma membrane organization by an anticancer lysophosphatidylcholine analogue induces intracellular acidification and internalization of plasma membrane transporters in yeast. The Journal of Biological Chemistry. 288: 8419-32. PMID 23344949 DOI: 10.1074/Jbc.M112.425744  0.351
2013 Cuesta-Marbán Á, Botet J, Czyz O, Cacharro LM, Gajate C, Hornillos V, Delgado J, Zhang H, Amat-Guerri F, Acuña AU, McMaster CR, Revuelta JL, Zaremberg V, Mollinedo F. Drug uptake, lipid rafts, and vesicle trafficking modulate resistance to an anticancer lysophosphatidylcholine analogue in yeast. The Journal of Biological Chemistry. 288: 8405-18. PMID 23335509 DOI: 10.1074/Jbc.M112.425769  0.371
2013 Mollinedo F, Gajate C, Gonzalez-Camacho F, Reis-Sobreiro M. Abstract 3331: Cluster of apoptotic signaling molecule-enriched rafts (CASMER) as a new target in the mechanism of action of the antitumor alkylphospholipid analogue edelfosine and cancer chemotherapy. Cancer Research. 73: 3331-3331. DOI: 10.1158/1538-7445.Am2013-3331  0.402
2013 Marcos IS, Moro RF, Costales I, Basabe P, Díez D, Mollinedo F, Urones JG. Biomimetic synthesis of an antitumour indole sesquiterpene alkaloid, 12-epi-ent-pentacyclindole Tetrahedron. 69: 7285-7289. DOI: 10.1016/J.Tet.2013.06.075  0.301
2012 Castro MÁ, Miguel del Corral JM, García PA, Rojo MV, Bento AC, Mollinedo F, Francesch AM, San Feliciano A. Lignopurines: a new family of hybrids between cyclolignans and purines. Synthesis and biological evaluation. European Journal of Medicinal Chemistry. 58: 377-89. PMID 23153810 DOI: 10.1016/J.Ejmech.2012.10.026  0.305
2012 García-Navas R, Munder M, Mollinedo F. Depletion of L-arginine induces autophagy as a cytoprotective response to endoplasmic reticulum stress in human T lymphocytes. Autophagy. 8: 1557-76. PMID 22874569 DOI: 10.4161/Auto.21315  0.32
2012 Gajate C, Matos-da-Silva M, Dakir EH, Fonteriz RI, Álvarez J, Mollinedo F. Antitumor alkyl-lysophospholipid analog edelfosine induces apoptosis in pancreatic cancer by targeting endoplasmic reticulum Oncogene. 31: 2627-2639. PMID 22056873 DOI: 10.1038/Onc.2011.446  0.305
2012 Marcos IS, Moro RF, Costales I, Basabe P, Díez D, Mollinedo F, Urones JG. Synthesis of 12-epi-ent-polyalthenol an antitumour indole sesquiterpene alkaloid Tetrahedron. 68: 7932-7940. DOI: 10.1016/J.Tet.2012.07.010  0.312
2011 Domínguez-Luis M, Lamana A, Vazquez J, García-Navas R, Mollinedo F, Sánchez-Madrid F, Díaz-González F, Urzainqui A. The metalloprotease ADAM8 is associated with and regulates the function of the adhesion receptor PSGL-1 through ERM proteins. European Journal of Immunology. 41: 3436-42. PMID 22229154 DOI: 10.1002/Eji.201141764  0.305
2011 Estella-Hermoso de Mendoza A, Préat V, Mollinedo F, Blanco-Prieto MJ. In vitro and in vivo efficacy of edelfosine-loaded lipid nanoparticles against glioma. Journal of Controlled Release : Official Journal of the Controlled Release Society. 156: 421-6. PMID 21821074 DOI: 10.1016/J.Jconrel.2011.07.030  0.313
2011 Gajate C, Mollinedo F. Lipid rafts and Fas/CD95 signaling in cancer chemotherapy. Recent Patents On Anti-Cancer Drug Discovery. 6: 274-83. PMID 21762074 DOI: 10.2174/157489211796957766  0.373
2011 Mollinedo F, Fernández M, Hornillos V, Delgado J, Amat-Guerri F, Acuña AU, Nieto-Miguel T, Villa-Pulgarín JA, González-García C, Ceña V, Gajate C. Involvement of lipid rafts in the localization and dysfunction effect of the antitumor ether phospholipid edelfosine in mitochondria. Cell Death & Disease. 2: e158. PMID 21593790 DOI: 10.1038/Cddis.2011.41  0.355
2011 Burgeiro A, Gajate C, Dakir el H, Villa-Pulgarín JA, Oliveira PJ, Mollinedo F. Involvement of mitochondrial and B-RAF/ERK signaling pathways in berberine-induced apoptosis in human melanoma cells. Anti-Cancer Drugs. 22: 507-18. PMID 21527846 DOI: 10.1097/Cad.0B013E32834438F6  0.386
2010 Selivanov VA, Vizán P, Mollinedo F, Fan TW, Lee PW, Cascante M. Edelfosine-induced metabolic changes in cancer cells that precede the overproduction of reactive oxygen species and apoptosis. Bmc Systems Biology. 4: 135. PMID 20925932 DOI: 10.1186/1752-0509-4-135  0.311
2010 Mollinedo F, Janssen H, de la Iglesia-Vicente J, Villa-Pulgarin JA, Calafat J. Selective fusion of azurophilic granules with Leishmania-containing phagosomes in human neutrophils. The Journal of Biological Chemistry. 285: 34528-36. PMID 20801889 DOI: 10.1074/Jbc.M110.125302  0.304
2010 Basabe P, de Román M, Marcos IS, Diez D, Blanco A, Bodero O, Mollinedo F, Sierra BG, Urones JG. Prenylflavonoids and prenyl/alkyl-phloroacetophenones: synthesis and antitumour biological evaluation. European Journal of Medicinal Chemistry. 45: 4258-69. PMID 20619940 DOI: 10.1016/J.Ejmech.2010.06.025  0.311
2010 Galisteo J, Navarro P, Campayo L, Yunta MJ, Gómez-Contreras F, Villa-Pulgarin JA, Sierra BG, Mollinedo F, Gonzalez J, Garcia-España E. Synthesis and cytotoxic activity of a new potential DNA bisintercalator: 1,4-Bis{3-[N-(4-chlorobenzo[g]phthalazin-1-yl)aminopropyl]}piperazine. Bioorganic & Medicinal Chemistry. 18: 5301-9. PMID 20538470 DOI: 10.1016/J.Bmc.2010.05.053  0.315
2010 Mollinedo F, Gajate C. Lipid rafts and clusters of apoptotic signaling molecule-enriched rafts in cancer therapy. Future Oncology (London, England). 6: 811-21. PMID 20465392 DOI: 10.2217/Fon.10.34  0.317
2010 Mollinedo F, Iglesia-Vicente Jdl, Gajate C, Mendoza AEd, Villa-Pulgarin JA, Campanero MA, Blanco-Prieto MJ. Lipid raft-targeted therapy in multiple myeloma Oncogene. 29: 3748-3757. PMID 20418917 DOI: 10.1038/Onc.2010.131  0.366
2010 Mollinedo F, de la Iglesia-Vicente J, Gajate C, Estella-Hermoso de Mendoza A, Villa-Pulgarin JA, de Frias M, Roué G, Gil J, Colomer D, Campanero MA, Blanco-Prieto MJ. In vitro and In vivo selective antitumor activity of Edelfosine against mantle cell lymphoma and chronic lymphocytic leukemia involving lipid rafts. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 2046-54. PMID 20233887 DOI: 10.1158/1078-0432.Ccr-09-2456  0.333
2010 Xie LX, Calafat J, Janssen H, de la Iglesia-Vicente J, Mollinedo F. Intracellular location of syntaxin 7 in human neutrophils. Immunology Letters. 129: 72-7. PMID 20170677 DOI: 10.1016/J.Imlet.2010.02.003  0.377
2010 Castro MA, del Corral JM, García PA, Rojo MV, de la Iglesia-Vicente J, Mollinedo F, Cuevas C, San Feliciano A. Synthesis and biological evaluation of new podophyllic aldehyde derivatives with cytotoxic and apoptosis-inducing activities. Journal of Medicinal Chemistry. 53: 983-93. PMID 20067289 DOI: 10.1021/Jm901373W  0.357
2010 Burgeiro A, Gajate C, Dakir EH, Oliveira PJ, Mollinedo F. Involvement of mitochondrial and survival signaling in berberine-induced apoptosis in melanoma cells. Bmc Proceedings. 4: 15. DOI: 10.1186/1753-6561-4-S2-P15  0.386
2009 Gajate C, Gonzalez-Camacho F, Mollinedo F. Involvement of raft aggregates enriched in Fas/CD95 death-inducing signaling complex in the antileukemic action of edelfosine in Jurkat cells. Plos One. 4: e5044. PMID 19352436 DOI: 10.1371/Journal.Pone.0005044  0.329
2009 Gajate C, Gonzalez-Camacho F, Mollinedo F. Lipid raft connection between extrinsic and intrinsic apoptotic pathways. Biochemical and Biophysical Research Communications. 380: 780-4. PMID 19338752 DOI: 10.1016/J.Bbrc.2009.01.147  0.387
2009 Estella-Hermoso de Mendoza A, Campanero MA, de la Iglesia-Vicente J, Gajate C, Mollinedo F, Blanco-Prieto MJ. Antitumor alkyl ether lipid edelfosine: tissue distribution and pharmacokinetic behavior in healthy and tumor-bearing immunosuppressed mice. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 858-64. PMID 19188156 DOI: 10.1158/1078-0432.Ccr-08-1654  0.305
2009 Lisa-Santamaría P, Neiman AM, Cuesta-Marbán A, Mollinedo F, Revuelta JL, Jiménez A. Human initiator caspases trigger apoptotic and autophagic phenotypes in Saccharomyces cerevisiae. Biochimica Et Biophysica Acta. 1793: 561-71. PMID 19166881 DOI: 10.1016/J.Bbamcr.2008.12.016  0.386
2008 Busto JV, Del Canto-Jañez E, Goñi FM, Mollinedo F, Alonso A. Combination of the anti-tumour cell ether lipid edelfosine with sterols abolishes haemolytic side effects of the drug. Journal of Chemical Biology. 1: 89-94. PMID 19568801 DOI: 10.1007/S12154-008-0009-Z  0.342
2008 Herrero-Turrión MJ, Calafat J, Janssen H, Fukuda M, Mollinedo F. Rab27a regulates exocytosis of tertiary and specific granules in human neutrophils. Journal of Immunology (Baltimore, Md. : 1950). 181: 3793-803. PMID 18768832 DOI: 10.4049/Jimmunol.181.6.3793  0.384
2008 Alzate JF, Arias A, Mollinedo F, Rico E, de la Iglesia-Vicente J, Jiménez-Ruiz A. Edelfosine induces an apoptotic process in Leishmania infantum that is regulated by the ectopic expression of Bcl-XL and Hrk. Antimicrobial Agents and Chemotherapy. 52: 3779-82. PMID 18644968 DOI: 10.1128/Aac.01665-07  0.347
2008 Mitsiades CS, Ocio EM, Pandiella A, Maiso P, Gajate C, Garayoa M, Vilanova D, Montero JC, Mitsiades N, McMullan CJ, Munshi NC, Hideshima T, Chauhan D, Aviles P, Otero G, ... ... Mollinedo F, et al. Aplidin, a marine organism-derived compound with potent antimyeloma activity in vitro and in vivo Cancer Research. 68: 5216-5225. PMID 18593922 DOI: 10.1158/0008-5472.Can-07-5725  0.378
2008 Mollinedo F, López-Pérez R, Gajate C. Differential gene expression patterns coupled to commitment and acquisition of phenotypic hallmarks during neutrophil differentiation of human leukaemia HL-60 cells. Gene. 419: 16-26. PMID 18547747 DOI: 10.1016/J.Gene.2008.04.015  0.321
2008 Nieto-Miguel T, Gajate C, González-Camacho F, Mollinedo F. Proapoptotic role of Hsp90 by its interaction with c-Jun N-terminal kinase in lipid rafts in edelfosine-mediated antileukemic therapy. Oncogene. 27: 1779-1787. PMID 17891170 DOI: 10.1038/Sj.Onc.1210816  0.363
2008 Pulido R, Alvarez V, Mollinedo F, Sánchez-Madrid F. Biochemical and functional characterization of the leucocyte tyrosine phosphatase CD45 (CD45RO, 180 kD) from human neutrophils. In vivo upregulation of CD45RO plasma membrane expression on patients undergoing haemodialysis Clinical and Experimental Immunology. 87: 329-335. PMID 1370931 DOI: 10.1111/J.1365-2249.1992.Tb02996.X  0.328
2007 Nieto-Miguel T, Fonteriz RI, Vay L, Gajate C, López-Hernández S, Mollinedo F. Endoplasmic reticulum stress in the proapoptotic action of edelfosine in solid tumor cells. Cancer Research. 67: 10368-78. PMID 17974980 DOI: 10.1158/0008-5472.Can-07-0278  0.374
2007 Marcos IS, Escola MA, Moro RF, Basabe P, Diez D, Sanz F, Mollinedo F, de la Iglesia-Vicente J, Sierra BG, Urones JG. Synthesis of novel antitumoural analogues of dysidiolide from ent-halimic acid. Bioorganic & Medicinal Chemistry. 15: 5719-37. PMID 17590342 DOI: 10.1016/J.Bmc.2007.06.007  0.305
2007 Gómez-Gaviro M, Domínguez-Luis M, Canchado J, Calafat J, Janssen H, Lara-Pezzi E, Fourie A, Tugores A, Valenzuela-Fernández A, Mollinedo F, Sánchez-Madrid F, Díaz-González F. Expression and regulation of the metalloproteinase ADAM-8 during human neutrophil pathophysiological activation and its catalytic activity on L-selectin shedding. Journal of Immunology (Baltimore, Md. : 1950). 178: 8053-63. PMID 17548643 DOI: 10.4049/Jimmunol.178.12.8053  0.385
2007 Busto JV, Sot J, Goñi FM, Mollinedo F, Alonso A. Surface-active properties of the antitumour ether lipid 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (edelfosine). Biochimica Et Biophysica Acta. 1768: 1855-60. PMID 17543274 DOI: 10.1016/J.Bbamem.2007.04.025  0.31
2007 Zhang H, Gajate C, Yu LP, Fang YX, Mollinedo F. Mitochondrial-derived ROS in edelfosine-induced apoptosis in yeasts and tumor cells. Acta Pharmacologica Sinica. 28: 888-94. PMID 17506948 DOI: 10.1111/J.1745-7254.2007.00568.X  0.379
2007 Gajate C, Mollinedo F. Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts. Blood. 109: 711-9. PMID 17003375 DOI: 10.1182/Blood-2006-04-016824  0.375
2007 Mollinedo F. Antitumour ether lipids: proapoptotic agents with multiple therapeutic indications Expert Opinion On Therapeutic Patents. 17: 385-405. DOI: 10.1517/13543776.17.4.385  0.397
2007 Ocio EM, Mitsiades C, Mateos MV, Maiso P, Mollinedo F, Garayoa M, Gajate C, Blade J, Prosper F, Lahuerta JJ, Mitsiades N, McMullan CJ, Munshi NC, Hideshima T, Chauhan D, et al. Antimyeloma Efficacy of Plitidepsin (Aplidin®): From Bench to the Bedside. Blood. 110: 1178-1178. DOI: 10.1182/Blood.V110.11.1178.1178  0.326
2006 Mollinedo F, Calafat J, Janssen H, Martín-Martín B, Canchado J, Nabokina SM, Gajate C. Combinatorial SNARE complexes modulate the secretion of cytoplasmic granules in human neutrophils. Journal of Immunology (Baltimore, Md. : 1950). 177: 2831-41. PMID 16920918 DOI: 10.4049/Jimmunol.177.5.2831  0.34
2006 Mollinedo F, Gajate C. Fas/CD95 death receptor and lipid rafts: new targets for apoptosis-directed cancer therapy. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 9: 51-73. PMID 16687251 DOI: 10.1016/J.Drup.2006.04.002  0.381
2006 Torrecillas A, Aroca-Aguilar JD, Aranda FJ, Gajate C, Mollinedo F, Corbalán-García S, de Godos A, Gómez-Fernández JC. Effects of the anti-neoplastic agent ET-18-OCH3 and some analogs on the biophysical properties of model membranes. International Journal of Pharmaceutics. 318: 28-40. PMID 16624506 DOI: 10.1016/J.Ijpharm.2006.03.008  0.322
2006 Nieto-Miguel T, Gajate C, Mollinedo F. Differential targets and subcellular localization of antitumor alkyl-lysophospholipid in leukemic versus solid tumor cells. The Journal of Biological Chemistry. 281: 14833-40. PMID 16540473 DOI: 10.1074/Jbc.M511251200  0.418
2005 Zaremberg V, Gajate C, Cacharro LM, Mollinedo F, McMaster CR. Cytotoxicity of an anti-cancer lysophospholipid through selective modification of lipid raft composition. The Journal of Biological Chemistry. 280: 38047-58. PMID 16155007 DOI: 10.1074/Jbc.M502849200  0.367
2005 Conesa-Zamora P, Mollinedo F, Corbalán-García S, Gómez-Fernández JC. A comparative study of the effect of the antineoplastic ether lipid 1-O-octadecyl-2-O-methyl-glycero-3-phosphocholine and some homologous compounds on PKC alpha and PKC epsilon. Biochimica Et Biophysica Acta. 1687: 110-9. PMID 15708359 DOI: 10.1016/J.Bbalip.2004.11.008  0.32
2005 Gajate C, Mollinedo F. Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy. The Journal of Biological Chemistry. 280: 11641-7. PMID 15659383 DOI: 10.1074/Jbc.M411781200  0.382
2005 Maya AB, Pérez-Melero C, Mateo C, Alonso D, Fernández JL, Gajate C, Mollinedo F, Peláez R, Caballero E, Medarde M. Further naphthylcombretastatins. An investigation on the role of the naphthalene moiety. Journal of Medicinal Chemistry. 48: 556-68. PMID 15658869 DOI: 10.1021/Jm0310737  0.36
2005 Munder M, Mollinedo F, Calafat J, Canchado J, Gil-Lamaignere C, Fuentes JM, Luckner C, Doschko G, Soler G, Eichmann K, Müller FM, Ho AD, Goerner M, Modolell M. Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity. Blood. 105: 2549-56. PMID 15546957 DOI: 10.1182/Blood-2004-07-2521  0.33
2004 Mollinedo F, Gajate C, Martín-Santamaría S, Gago F. ET-18-OCH3 (edelfosine): a selective antitumour lipid targeting apoptosis through intracellular activation of Fas/CD95 death receptor. Current Medicinal Chemistry. 11: 3163-84. PMID 15579006 DOI: 10.2174/0929867043363703  0.397
2004 Quesada E, Delgado J, Gajate C, Mollinedo F, Acuña AU, Amat-Guerri F. Fluorescent phenylpolyene analogues of the ether phospholipid edelfosine for the selective labeling of cancer cells. Journal of Medicinal Chemistry. 47: 5333-5. PMID 15481970 DOI: 10.1021/Jm049808A  0.374
2004 Gajate C, Canto-Jañez Ed, Acuña AU, Amat-Guerri F, Geijo E, Santos-Beneit AM, Veldman RJ, Mollinedo F. Intracellular Triggering of Fas Aggregation and Recruitment of Apoptotic Molecules into Fas-enriched Rafts in Selective Tumor Cell Apoptosis Journal of Experimental Medicine. 200: 353-365. PMID 15289504 DOI: 10.1084/Jem.20040213  0.41
2004 Castro MA, Miguel del Corral JM, Gordaliza M, García PA, Gómez-Zurita MA, García-Grávalos MD, de la Iglesia-Vicente J, Gajate C, An F, Mollinedo F, San Feliciano A. Synthesis and biological evaluation of new selective cytotoxic cyclolignans derived from podophyllotoxin. Journal of Medicinal Chemistry. 47: 1214-22. PMID 14971901 DOI: 10.1021/Jm030978H  0.359
2003 Mollinedo F, Gajate C. Microtubules, microtubule-interfering agents and apoptosis. Apoptosis. 8: 413-450. PMID 12975575 DOI: 10.1023/A:1025513106330  0.346
2003 Mollinedo F, Martín-Martín B, Calafat J, Nabokina SM, Lazo PA. Role of Vesicle-Associated Membrane Protein-2, Through Q-Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptor/R-Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptor Interaction, in the Exocytosis of Specific and Tertiary Granules of Human Neutrophils Journal of Immunology. 170: 1034-1042. PMID 12517971 DOI: 10.4049/Jimmunol.170.2.1034  0.358
2002 Gajate C, Mollinedo F. Biological activities, mechanisms of action and biomedical prospect of the antitumor ether phospholipid ET-18-OCH3 (edelfosine), a proapoptotic agent in tumor cells Current Drug Metabolism. 3: 491-525. PMID 12369895 DOI: 10.2174/1389200023337225  0.309
2002 Gajate C, An F, Mollinedo F. Differential cytostatic and apoptotic effects of ecteinascidin-743 in cancer cells: Transcription-dependent cell cycle arrest and transcription-independent JNK and mitochondrial mediated apoptosis Journal of Biological Chemistry. 277: 41580-41589. PMID 12198119 DOI: 10.1074/Jbc.M204644200  0.382
2001 Gajate C, Mollinedo F. The antitumor ether lipid ET-18-OCH3 induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells Blood. 98: 3860-3863. PMID 11739199 DOI: 10.1182/Blood.V98.13.3860  0.396
2001 Eckhart L, Henry M, Santos-Beneit AM, Schmitz I, Krueger A, Fischer H, Bach J, Ban J, Kirchhoff S, Krammer PH, Mollinedo F, Tschachler E. Alternative splicing of caspase-8 mRNA during differentiation of human leukocytes. Biochemical and Biophysical Research Communications. 289: 777-781. PMID 11735112 DOI: 10.1006/Bbrc.2001.6055  0.337
2001 Lazo PA, Nadal M, Ferrer M, Area E, Hernandez-Torres J, Nabokina SM, Mollinedo F, Estivill X. Genomic organization, chromosomal localization, alternative splicing, and isoforms of the human synaptosome-associated protein-23 gene implicated in vesicle-membrane fusion processes. Human Genetics. 108: 211-215. PMID 11354632 DOI: 10.1007/S004390100480  0.302
2000 Santos-Beneit AM, Mollinedo F. Expression of genes involved in initiation, regulation, and execution of apoptosis in human neutrophils and during neutrophil differentiation of HL-60 cells Journal of Leukocyte Biology. 67: 712-724. PMID 10811013 DOI: 10.1002/Jlb.67.5.712  0.307
2000 Gajate C, Santos-Beneit AM, Macho A, Lazaro MdC, Rojas AH, Modolell M, Muoz E, Mollinedo F. Involvement of mitochondria and caspase‐3 in ET‐18‐OCH3‐induced apoptosis of human leukemic cells International Journal of Cancer. 86: 208-218. PMID 10738248 DOI: 10.1002/(Sici)1097-0215(20000415)86:2<208::Aid-Ijc10>3.0.Co;2-E  0.387
2000 Gajate C, Fonteriz RI, Cabaner C, Alvarez-Noves G, Alvarez-Rodriguez Y, Modolell M, Mollinedo F. Intracellular triggering of Fas, independently of FasL, as a new mechanism of antitumor ether lipid-induced apoptosis. International Journal of Cancer. 85: 674-682. PMID 10699948 DOI: 10.1002/(Sici)1097-0215(20000301)85:5<674::Aid-Ijc13>3.0.Co;2-Z  0.376
2000 Martı́n-Martı́n B, Nabokina SM, Blasi J, Lazo PA, Mollinedo F. Involvement of SNAP-23 and syntaxin 6 in human neutrophil exocytosis. Blood. 96: 2574-2583. DOI: 10.1182/Blood.V96.7.2574.H8002574_2574_2583  0.362
1999 Cabaner C, Gajate C, Macho A, Muñoz E, Modolell M, Mollinedo F. Induction of apoptosis in human mitogen-activated peripheral blood T-lymphocytes by the ether phospholipid ET-18-OCH3: involvement of the Fas receptor/ligand system. British Journal of Pharmacology. 127: 813-825. PMID 10433487 DOI: 10.1038/Sj.Bjp.0702606  0.37
1999 Macho A, Calzado MA, Muñoz-Blanco J, Gómez-Díaz C, Gajate C, Mollinedo F, Navas P, Muñoz E. Selective induction of apoptosis by capsaicin in transformed cells: the role of reactive oxygen species and calcium. Cell Death & Differentiation. 6: 155-165. PMID 10200562 DOI: 10.1038/Sj.Cdd.4400465  0.376
1998 Mollinedo F, Martín‐Martín B, Gajate C, Lazo PA. Physiological activation of human neutrophils down‐regulates CD53 cell surface antigen Journal of Leukocyte Biology. 63: 699-706. PMID 9620662 DOI: 10.1002/Jlb.63.6.699  0.315
1998 Gajate C, Santos-Beneit A, Modolell M, Mollinedo F. Involvement of c-Jun NH2-Terminal Kinase Activation and c-Jun in the Induction of Apoptosis by the Ether Phospholipid 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphocholine Molecular Pharmacology. 53: 602-612. PMID 9547349 DOI: 10.1124/Mol.53.4.602  0.376
1997 Mollinedo F, Nakajima M, Llorens A, Barbosa E, Callejo S, Gajate C, Fabra A. Major co-localization of the extracellular-matrix degradative enzymes heparanase and gelatinase in tertiary granules of human neutrophils. Biochemical Journal. 327: 917-923. PMID 9581574 DOI: 10.1042/Bj3270917  0.352
1997 Nabokina S, Egea G, Blasi J, Mollinedo F. Intracellular Location of SNAP-25 in Human Neutrophils☆ Biochemical and Biophysical Research Communications. 239: 592-597. PMID 9344876 DOI: 10.1006/Bbrc.1997.7515  0.343
1997 Alonso MT, Gajate C, Mollinedo F, Modolell M, Alvarez J, García-Sancho J. Dissociation of the effects of the antitumour ether lipid ET‐18‐OCH3 on cytosolic calcium and on apoptosis British Journal of Pharmacology. 121: 1364-1368. PMID 9257915 DOI: 10.1038/Sj.Bjp.0701271  0.369
1997 Mollinedo F, Lazo PA. Identification of two isoforms of the vesicle-membrane fusion protein SNAP-23 in human neutrophils and HL-60 cells Biochemical and Biophysical Research Communications. 231: 808-812. PMID 9070898 DOI: 10.1006/Bbrc.1997.6196  0.34
1997 Mollinedo F, Fontán G, Barasoain I, Lazo PA. Recurrent infectious diseases in human CD53 deficiency. Clinical and Vaccine Immunology. 4: 229-231. DOI: 10.1128/Cdli.4.2.229-231.1997  0.306
1996 Gajate C, Alonso MT, Schimmang T, Mollinedo F. C-Fos Is Not Essential for Apoptosis Biochemical and Biophysical Research Communications. 218: 267-272. PMID 8573144 DOI: 10.1006/Bbrc.1996.0047  0.311
1995 Pérez-Sala D, Collado-Escobar D, Mollinedo F. Intracellular alkalinization suppresses lovastatin-induced apoptosis in HL-60 cells through the inactivation of a pH-dependent endonuclease. Journal of Biological Chemistry. 270: 6235-6242. PMID 7890761 DOI: 10.1074/Jbc.270.11.6235  0.347
1995 Pérez-Sala D, Mollinedo F. Inhibition of N‐linked glycosylation induces early apoptosis in human promyelocytic HL‐60 cells Journal of Cellular Physiology. 163: 523-531. PMID 7775595 DOI: 10.1002/Jcp.1041630312  0.41
1995 Díaz-González F, González-Alvaro I, Campanero MR, Mollinedo F, Pozo MAd, Muñoz C, Pivel JP, Sánchez-Madrid F. Prevention of in vitro neutrophil-endothelial attachment through shedding of L-selectin by nonsteroidal antiinflammatory drugs. Journal of Clinical Investigation. 95: 1756-1765. PMID 7535797 DOI: 10.1172/Jci117853  0.368
1994 Perezsala D, Mollinedo F. Inhibition of Isoprenoid Biosynthesis Induces Apoptosis in Human Promyelocytic HL-60 Cells Biochemical and Biophysical Research Communications. 199: 1209-1215. PMID 8147861 DOI: 10.1006/Bbrc.1994.1359  0.39
1994 Mollinedo F, Gajate C, Modolell M. The ether lipid 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine induces expression of fos and jun proto-oncogenes and activates AP-1 transcription factor in human leukaemic cells. Biochemical Journal. 302: 325-329. PMID 8092982 DOI: 10.1042/Bj3020325  0.361
1994 Collado-Escobar D, Mollinedo F. Dexamethasone modifies the functional responses of the granulocytic differentiating HL-60 cells. Biochemical Journal. 299: 553-559. PMID 7909661 DOI: 10.1042/Bj2990553  0.395
1993 Mollinedo F, Perez-Sala D, Gajate C, Jimenez B, Rodriguez P, Lacal JC. Localization of rap1 and rap2 proteins in the gelatinase‐containing granules of human neutrophils Febs Letters. 326: 209-214. PMID 8391995 DOI: 10.1016/0014-5793(93)81792-X  0.315
1993 Mollinedo F, Gajate C, Tugores A, Flores I, Naranjo JR. Differences in expression of transcription factor AP-1 in human promyelocytic HL-60 cells during differentiation towards macrophages versus granulocytes. Biochemical Journal. 294: 137-144. PMID 8363564 DOI: 10.1042/Bj2940137  0.358
1992 Balboa MA, Balsinde J, Aramburu J, Mollinedo F, López-Botet M. Phospholipase D activation in human natural killer cells through the Kp43 and CD16 surface antigens takes place by different mechanisms. Involvement of the phospholipase D pathway in tumor necrosis factor alpha synthesis. The Journal of Experimental Medicine. 176: 9-17. PMID 1535370 DOI: 10.1084/Jem.176.1.9  0.611
1991 Roldan ERS, Mollinedo F. Diacylglycerol stimulates the Ca2(+)-dependent phospholipase A2 of ram spermatozoa. Biochemical and Biophysical Research Communications. 176: 294-300. PMID 2018523 DOI: 10.1016/0006-291X(91)90923-U  0.357
1991 Mollinedo F, Naranjo JR. Uncoupled changes in the expression of the jun family members during myeloid cell differentiation European Journal of Biochemistry. 200: 483-486. PMID 1909627 DOI: 10.1111/J.1432-1033.1991.Tb16208.X  0.338
1991 Garcia MC, Garcia C, Gijon MA, Fernandez-Gallardo S, Mollinedo F, Crespo MS. Metabolism of platelet-activating factor in human haematopoietic cell lines. Differences between myeloid and lymphoid cells. Biochemical Journal. 273: 573-578. PMID 1847616 DOI: 10.1042/Bj2730573  0.39
1991 Mollinedo F, Gajate C, Schneider DL. Cytochrome b co-fractionates with gelatinase-containing granules in human neutrophils. Molecular and Cellular Biochemistry. 105: 49-60. PMID 1656202 DOI: 10.1007/Bf00230374  0.368
1990 Balsinde J, Mollinedo F. Phosphatidylinositol hydrolysis by human plasma phospholipase D Febs Letters. 259: 237-240. PMID 2294015 DOI: 10.1016/0014-5793(90)80017-D  0.578
1990 Balsinde J, Mollinedo F. Induction of the oxidative response and of concanavalin A-binding capacity in maturing human U937 cells. Biochimica Et Biophysica Acta. 1052: 90-95. PMID 2157504 DOI: 10.1016/0167-4889(90)90061-H  0.596
1990 Diez E, Balsinde J, Mollinedo F. Subcellular distribution of fatty acids, phospholipids and phospholipase A2 in human neutrophils. Biochimica Et Biophysica Acta. 1047: 83-9. PMID 2123404 DOI: 10.1016/0005-2760(90)90264-X  0.539
1990 Lacal PM, Balsinde J, Cabañas C, Bernabeu C, Sánchez-Madrid F, Mollinedo F. The CD11c antigen couples concanavalin A binding to generation of superoxide anion in human phagocytes. Biochemical Journal. 268: 707-712. PMID 1973035 DOI: 10.1042/Bj2680707  0.604
1989 Balsinde J, Diez E, Fernandez B, Mollinedo F. Biochemical characterization of phospholipase D activity from human neutrophils. European Journal of Biochemistry / Febs. 186: 717-24. PMID 2558015 DOI: 10.1111/J.1432-1033.1989.Tb15265.X  0.597
1989 Alvarez J, García‐Sancho J, Mollinedo F, Sanchez A. Intracellular Ca2+ potentiates Na+/H+ exchange and cell differentiation induced by phorbol ester in U937 cells Febs Journal. 183: 709-714. PMID 2550223 DOI: 10.1111/J.1432-1033.1989.Tb21102.X  0.375
1989 Cabañas C, Lacal P, Mollinedo F, López-Rivas A, Sánchez-Madrid F, Bernabeu C. A monoclonal antibody to CD11c antigen inhibits the production of superoxide anion induced by concanavalin A in PMA-differentiated U-937 cells. Immunology Letters. 20: 193-197. PMID 2541080 DOI: 10.1016/0165-2478(89)90079-5  0.319
1989 Pulido R, Lacal P, Mollinedo F, Sánchez-Madrid F. Biochemical and antigenic characterization of CD45 polypeptides expressed on plasma membrane and internal granules of human neutrophils. Febs Letters. 249: 337-342. PMID 2525488 DOI: 10.1016/0014-5793(89)80654-4  0.303
1988 Mollinedo F, Gómez-Cambronero J, Cano E, Sánchez-Crespo M. Intracellular localization of platelet-activating factor synthesis in human neutrophils. Biochemical and Biophysical Research Communications. 154: 1232-1239. PMID 3408495 DOI: 10.1016/0006-291X(88)90271-9  0.394
1988 Lacal P, Pulido R, Sáchez-Madrid F, Cabañas C, Mollinedo F. Intracellular localization of a leukocyte adhesion glycoprotein family in the tertiary granules of human neutrophils. Biochemical and Biophysical Research Communications. 154: 641-647. PMID 3135806 DOI: 10.1016/0006-291X(88)90187-8  0.375
1988 Balsinde J, Diez E, Mollinedo F. Phosphatidylinositol-specific phospholipase D: a pathway for generation of a second messenger. Biochemical and Biophysical Research Communications. 154: 502-8. PMID 3135804 DOI: 10.1016/0006-291X(88)90168-4  0.591
1988 Balsinde J, Mollinedo F. Specific activation by concanavalin A of the superoxide anion generation capacity during U937 differentiation Biochemical and Biophysical Research Communications. 151: 802-808. PMID 2831904 DOI: 10.1016/S0006-291X(88)80352-8  0.6
1988 Fernandez-Luna JL, Leyva-Cobian F, Mollinedo F. Identification of the protein HC receptor Febs Letters. 236: 471-474. PMID 2457516 DOI: 10.1016/0014-5793(88)80079-6  0.336
1988 Balsinde J, Díez E, Schüller A, Mollinedo F. Phospholipase A2 activity in resting and activated human neutrophils. Substrate specificity, pH dependence, and subcellular localization. Journal of Biological Chemistry. 263: 1929-1936. DOI: 10.13039/501100003339  0.59
1987 Lacal P, Mollinedo F, Larraga V. Human neutrophil plasma membrane. Specific labelling, topological distribution of proteins and surface antigen detection. Molecular and Cellular Biochemistry. 77: 161-171. PMID 3325821 DOI: 10.1007/Bf00221925  0.328
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