Chandra Verma, PhD - Publications

Bioinformatics Institute A*Star, Agency for Science Technology & Research 
Molecular Modeling, Structural Biology, p53, kinases

117 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Arruabarrena-Aristorena A, Maag JLV, Kittane S, Cai Y, Karthaus WR, Ladewig E, Park J, Kannan S, Ferrando L, Cocco E, Ho SY, Tan DS, Sallaku M, Wu F, Acevedo B, ... ... Verma CS, et al. FOXA1 Mutations Reveal Distinct Chromatin Profiles and Influence Therapeutic Response in Breast Cancer. Cancer Cell. PMID 32888433 DOI: 10.1016/j.ccell.2020.08.003  0.36
2020 Kannan S, Aronica PGA, Ng S, Gek Lian DT, Frosi Y, Chee S, Shimin J, Yuen TY, Sadruddin A, Kaan HYK, Chandramohan A, Wong JH, Tan YS, Chang ZW, Ferrer-Gago FJ, ... ... Verma CS, et al. Macrocyclization of an all-d linear α-helical peptide imparts cellular permeability. Chemical Science. 11: 5577-5591. PMID 32874502 DOI: 10.1039/c9sc06383h  0.4
2020 Tan YS, Verma CS. Straightforward incorporation of multiple ligand types into molecular dynamics simulations for efficient binding site detection and characterization. Journal of Chemical Theory and Computation. PMID 32810406 DOI: 10.1021/acs.jctc.0c00405  0.4
2020 Kumar AP, Verma CS, Lukman S. Structural dynamics and allostery of Rab proteins: strategies for drug discovery and design. Briefings in Bioinformatics. PMID 31950981 DOI: 10.1093/bib/bbz161  0.6
2019 Yuen TY, Brown CJ, Xue Y, Tan YS, Ferrer Gago FJ, Lee XE, Neo JY, Thean D, Kaan HYK, Partridge AW, Verma CS, Lane DP, Johannes CW. Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles. Chemical Science. 10: 6457-6466. PMID 31316744 DOI: 10.1039/c9sc01456j  0.4
2019 Partridge AW, Kaan HYK, Juang YC, Sadruddin A, Lim S, Brown CJ, Ng S, Thean D, Ferrer F, Johannes C, Yuen TY, Kannan S, Aronica P, Tan YS, Pradhan MR, ... Verma CS, et al. Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Exploring Biophysical and Cellular Permeability Properties. Molecules (Basel, Switzerland). 24. PMID 31226791 DOI: 10.3390/molecules24122292  0.4
2019 Charoenpattarapreeda J, Tan YS, Iegre J, Walsh SJ, Fowler E, Eapen RS, Wu Y, Sore HF, Verma CS, Itzhaki L, Spring DR. Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides. Chemical Communications (Cambridge, England). PMID 31225847 DOI: 10.1039/c9cc04022f  0.4
2019 Iegre J, Brear P, Baker DJ, Tan YS, Atkinson EL, Sore HF, O' Donovan DH, Verma CS, Hyvönen M, Spring DR. Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein-protein interaction. Chemical Science. 10: 5056-5063. PMID 31183056 DOI: 10.1039/c9sc00798a  0.4
2019 Tan YS, Mhoumadi Y, Verma CS. Roles of computational modelling in understanding p53 structure, biology, and its therapeutic targeting. Journal of Molecular Cell Biology. PMID 30726928 DOI: 10.1093/jmcb/mjz009  0.4
2019 Yadahalli S, Neira JL, Johnson CM, Tan YS, Rowling PJE, Chattopadhyay A, Verma CS, Itzhaki LS. Kinetic and thermodynamic effects of phosphorylation on p53 binding to MDM2. Scientific Reports. 9: 693. PMID 30679555 DOI: 10.1038/s41598-018-36589-5  0.4
2018 Liu BH, Jobichen C, Chia CSB, Chan THM, Tang JP, Chung TXY, Li J, Poulsen A, Hung AW, Koh-Stenta X, Tan YS, Verma CS, Tan HK, Wu CS, Li F, et al. Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide. Proceedings of the National Academy of Sciences of the United States of America. PMID 29976840 DOI: 10.1073/pnas.1801253115  0.4
2018 Iegre J, Ahmed NS, Gaynord JS, Wu Y, Herlihy KM, Tan YS, Lopes-Pires ME, Jha R, Lau YH, Sore HF, Verma C, O' Donovan DH, Pugh N, Spring DR. Stapled peptides as a new technology to investigate protein-protein interactions in human platelets. Chemical Science. 9: 4638-4643. PMID 29899957 DOI: 10.1039/c8sc00284c  0.4
2018 Sawyer TK, Partridge AW, Kaan HYK, Juang YC, Lim S, Johannes C, Yuen TY, Verma C, Kannan S, Aronica P, Tan YS, Sherborne B, Ha S, Hochman J, Chen S, et al. Macrocyclic α helical peptide therapeutic modality: A perspective of learnings and challenges. Bioorganic & Medicinal Chemistry. PMID 29598901 DOI: 10.1016/j.bmc.2018.03.008  0.4
2017 Chan JV, Ping Koh DX, Liu Y, Joseph TL, Lane DP, Verma CS, Tan YS. Role of the N-terminal lid in regulating the interaction of phosphorylated MDMX with p53. Oncotarget. 8: 112825-112840. PMID 29348869 DOI: 10.18632/oncotarget.22829  0.4
2017 Hui EY, Rout B, Tan YS, Verma CS, Chan KP, Johannes CW. An intramolecular tryptophan-condensation approach for peptide stapling. Organic & Biomolecular Chemistry. PMID 29271460 DOI: 10.1039/c7ob02667f  0.4
2017 Prasanna Kumar A, Nguyen MN, Verma C, Lukman S. Structural analysis of protein tyrosine phosphatase 1B reveals potentially druggable allosteric binding sites. Proteins. PMID 29235148 DOI: 10.1002/prot.25440  0.6
2017 Xu W, Lau YH, Fischer G, Tan YS, Chattopadhyay A, de la Roche M, Hyvonen M, Verma CS, Spring DR, Itzhaki LS. Macrocyclized extended peptides: Inhibiting the substrate-recognition domain of tankyrase. Journal of the American Chemical Society. PMID 28084734 DOI: 10.1021/jacs.6b10234  0.4
2016 Wiedmann MM, Tan YS, Wu Y, Aibara S, Xu W, Sore HF, Verma CS, Itzhaki L, Stewart M, Brenton JD, Spring DR. Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer. Angewandte Chemie (International Ed. in English). PMID 27918136 DOI: 10.1002/anie.201609427  0.4
2016 Siau JW, Coffill CR, Zhang WV, Tan YS, Hundt J, Lane D, Verma C, Ghadessy F. Functional characterization of p53 pathway components in the ancient metazoan Trichoplax adhaerens. Scientific Reports. 6: 33972. PMID 27678309 DOI: 10.1038/srep33972  1
2016 Tan YS, Reeks J, Brown CJ, Thean D, Ferrer Gago FJ, Yuen TY, Goh ET, Lee XE, Jennings CE, Joseph TL, Lakshminarayanan R, Lane DP, Noble ME, Verma CS. Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design. The Journal of Physical Chemistry Letters. PMID 27532490 DOI: 10.1021/acs.jpclett.6b01525  1
2016 Castel P, Ellis H, Bago R, Toska E, Razavi P, Carmona FJ, Kannan S, Verma CS, Dickler M, Chandarlapaty S, Brogi E, Alessi DR, Baselga J, Scaltriti M. PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition. Cancer Cell. PMID 27451907 DOI: 10.1016/j.ccell.2016.06.004  0.36
2016 Marzinek JK, Holdbrook DA, Huber RG, Verma C, Bond PJ. Pushing the Envelope: Dengue Viral Membrane Coaxed into Shape by Molecular Simulations. Structure (London, England : 1993). PMID 27396828 DOI: 10.1016/j.str.2016.05.014  1
2016 Tan YS, Lane DP, Verma CS. Stapled peptide design: principles and roles of computation. Drug Discovery Today. PMID 27326912 DOI: 10.1016/j.drudis.2016.06.012  0.4
2016 Lakshminarayanan R, Tan WX, Aung TT, Goh ET, Muruganantham N, Li J, Chang JY, Dikshit N, Saraswathi P, Lim RR, Kang TS, Balamuralidhar V, Sukumaran B, Verma CS, Sivaraman J, et al. Branched Peptide, B2088, Disrupts the Supramolecular Organization of Lipopolysaccharides and Sensitizes the Gram-negative Bacteria. Scientific Reports. 6: 25905. PMID 27174567 DOI: 10.1038/srep25905  1
2016 Fox SJ, Fazil MH, Dhand C, Venkatesh M, Goh ET, Harini S, Eugene C, Lim RR, Ramakrishna S, Chaurasia SS, Beuerman RW, Verma CS, Verma NK, Loh XJ, Lakshminarayanan R. Insight into membrane selectivity of linear and branched polyethylenimines and their potential as biocides for advanced wound dressings. Acta Biomaterialia. PMID 27079762 DOI: 10.1016/j.actbio.2016.04.015  1
2016 Chattopadhyay A, O'Connor CJ, Zhang F, Galvagnion C, Galloway WR, Tan YS, Stokes JE, Rahman T, Verma C, Spring DR, Itzhaki LS. Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell. Scientific Reports. 6: 23732. PMID 27046077 DOI: 10.1038/srep23732  1
2016 Kannan S, Lane DP, Verma CS. Long range recognition and selection in IDPs: the interactions of the C-terminus of p53. Scientific Reports. 6: 23750. PMID 27030593 DOI: 10.1038/srep23750  1
2016 Ravi Kumar V, Verma C, Umapathy S. Molecular dynamics and simulations study on the vibrational and electronic solvatochromism of benzophenone. The Journal of Chemical Physics. 144: 064302. PMID 26874483 DOI: 10.1063/1.4941058  1
2016 Coffill CR, Lee AP, Siau JW, Chee SM, Joseph TL, Tan YS, Madhumalar A, Tay BH, Brenner S, Verma CS, Ghadessy FJ, Venkatesh B, Lane DP. The p53-Mdm2 interaction and the E3 ligase activity of Mdm2/Mdm4 are conserved from lampreys to humans. Genes & Development. PMID 26798135 DOI: 10.1101/gad.274118.115  1
2016 Marzinek JK, Lakshminarayanan R, Goh E, Huber RG, Panzade S, Verma C, Bond PJ. Characterizing the Conformational Landscape of Flavivirus Fusion Peptides via Simulation and Experiment. Scientific Reports. 6: 19160. PMID 26785994 DOI: 10.1038/srep19160  1
2015 Lau YH, Wu Y, Rossmann M, Tan BX, de Andrade P, Tan YS, Verma C, McKenzie GJ, Venkitaraman AR, Hyvönen M, Spring DR. Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides. Angewandte Chemie (International Ed. in English). 54: 15410-3. PMID 26768531 DOI: 10.1002/anie.201508416  1
2015 ElSawy KM, Lane DP, Verma CS, Caves LS. Recognition Dynamics of p53 and MDM2: Implications for Peptide Design. The Journal of Physical Chemistry. B. PMID 26701330 DOI: 10.1021/acs.jpcb.5b11162  1
2015 Koh JJ, Zou H, Lin S, Lin H, Soh RT, Lim FH, Koh WL, Li J, Lakshminarayanan R, Verma C, Tan DT, Cao D, Beuerman RW, Liu S. Nonpeptidic Amphiphilic Xanthone Derivatives: Structure-Activity Relationship and Membrane-Targeting Properties. Journal of Medicinal Chemistry. PMID 26681070 DOI: 10.1021/acs.jmedchem.5b01500  1
2015 Pradhan MR, Pal A, Hu Z, Kannan S, Kwoh CK, Lane DP, Verma CS. Wetting of non-conserved residue-backbones: A feature indicative of aggregation associated regions of proteins. Proteins. PMID 26677132 DOI: 10.1002/prot.24976  1
2015 Carmona FJ, Montemurro F, Kannan S, Rossi V, Verma C, Baselga J, Scaltriti M. AKT signaling in ERBB2-amplified breast cancer. Pharmacology & Therapeutics. PMID 26645663 DOI: 10.1016/j.pharmthera.2015.11.013  1
2015 Tan YS, Spring DR, Abell C, Verma CS. The Application of Ligand-Mapping Molecular Dynamics Simulations to the Rational Design of Peptidic Modulators of Protein-Protein Interactions. Journal of Chemical Theory and Computation. 11: 3199-3210. PMID 26575757 DOI: 10.1021/ct5010577  1
2015 Petrone L, Kumar A, Sutanto CN, Patil NJ, Kannan S, Palaniappan A, Amini S, Zappone B, Verma C, Miserez A. Mussel adhesion is dictated by time-regulated secretion and molecular conformation of mussel adhesive proteins. Nature Communications. 6: 8737. PMID 26508080 DOI: 10.1038/ncomms9737  1
2015 Ng JW, Lama D, Lukman S, Lane DP, Verma CS, Sim AY. R248Q mutation - Beyond p53-DNA binding. Proteins. PMID 26442703 DOI: 10.1002/prot.24940  0.6
2015 Iyengar PV, Jaynes P, Rodon L, Lama D, Law KP, Lim YP, Verma C, Seoane J, Eichhorn PJ. USP15 regulates SMURF2 kinetics through C-lobe mediated deubiquitination. Scientific Reports. 5: 14733. PMID 26435193 DOI: 10.1038/srep14733  1
2015 Lama D, Brown CJ, Lane DP, Verma CS. Gating by Tryptophan 73 Exposes a Cryptic Pocket at the Protein-Binding Interface of the Oncogenic eIF4E Protein. Biochemistry. PMID 26427906 DOI: 10.1021/acs.biochem.5b00812  1
2015 Ochsenbein F, Morelli X, Verma C. Editorial. Protein-Protein Interaction Analysis and Modulation. Progress in Biophysics and Molecular Biology. 119: 1. PMID 26345255 DOI: 10.1016/j.pbiomolbio.2015.08.019  1
2015 Narayan V, Landre V, Ning J, Hernychova L, Muller P, Verma C, Walkinshaw MD, Blackburn EA, Ball KL. Protein:protein Interactions Modulate the Docking-Dependent E3-Ubiquitin Ligase Activity of CHIP. Molecular & Cellular Proteomics : McP. PMID 26330542 DOI: 10.1074/mcp.M115.051169  1
2015 Koh JJ, Lin H, Caroline V, Chew YS, Pang LM, Aung TT, Li J, Lakshminarayanan R, Tan DT, Verma CS, Tan AL, Beuerman RW, Liu S. N-Lipidated Peptide Dimers: Effective Antibacterial Agents against Gram-Negative Pathogens through Lipopolysaccharide Permeabilization. Journal of Medicinal Chemistry. PMID 26214729 DOI: 10.1021/acs.jmedchem.5b00628  1
2015 Lee J, Daniels V, Sands ZA, Lebon F, Shi J, Biggin PC. Exploring the interaction of SV2A with racetams using homology modelling, molecular dynamics and site-directed mutagenesis. Plos One. 10: e0116589. PMID 25692762 DOI: 10.1371/journal.pone.0116589  1
2015 ElSawy KM, Sim A, Lane DP, Verma CS, Caves LS. A spatiotemporal characterization of the effect of p53 phosphorylation on its interaction with MDM2. Cell Cycle (Georgetown, Tex.). 14: 179-88. PMID 25584963 DOI: 10.4161/15384101.2014.989043  1
2015 Li J, Liu S, Koh JJ, Zou H, Lakshminarayanan R, Bai Y, Pervushin K, Zhou L, Verma C, Beuerman RW. A novel fragment based strategy for membrane active antimicrobials against MRSA. Biochimica Et Biophysica Acta. 1848: 1023-31. PMID 25582665 DOI: 10.1016/j.bbamem.2015.01.001  1
2015 Ma W, Fuentes G, Shi X, Verma C, Radda GK, Han W. FoxO1 negatively regulates leptin-induced POMC transcription through its direct interaction with STAT3. The Biochemical Journal. 466: 291-8. PMID 25510553 DOI: 10.1042/BJ20141109  1
2015 Koh JJ, Lin S, Aung TT, Lim F, Zou H, Bai Y, Li J, Lin H, Pang LM, Koh WL, Salleh SM, Lakshminarayanan R, Zhou L, Qiu S, Pervushin K, ... Verma C, et al. Amino acid modified xanthone derivatives: novel, highly promising membrane-active antimicrobials for multidrug-resistant Gram-positive bacterial infections. Journal of Medicinal Chemistry. 58: 739-52. PMID 25474410 DOI: 10.1021/jm501285x  1
2015 Ng YZ, Kannan S, Lane DP, Fuentes G, Verma CS. mAb806 binding to epidermal growth factor receptor: a computational study. Proteins. 83: 153-68. PMID 25370927 DOI: 10.1002/prot.24714  1
2015 Kannan S, Poulsen A, Yang HY, Ho M, Ang SH, Eldwin TSW, Jeyaraj DA, Chennamaneni LR, Liu B, Hill J, Verma CS, Nacro K. Probing the binding mechanism of Mnk inhibitors by docking and molecular dynamics simulations Biochemistry. 54: 32-46. DOI: 10.1021/bi501261j  1
2015 Jiang Y, Tan CY, Tan SY, Wong MSF, Chen YF, Zhang L, Yao K, Gan SKE, Verma C, Tan YJ. SAW sensor for Influenza A virus detection enabled with efficient surface functionalization Sensors and Actuators, B: Chemical. 209: 78-84. DOI: 10.1016/j.snb.2014.11.103  1
2015 Sangith N, Srinivasaraghavan K, Sahu I, Desai A, Medipally S, Somavarappu AK, Verma C, Venkatraman P. Corrigendum to "Discovery of novel interacting partners of PSMD9, a proteasomal chaperone: Role of an Atypical and versatile PDZ-domain motif interaction and identification of putative functional modules" [FEBS Open Bio 4 (2014) 571-583] Febs Open Bio. DOI: 10.1016/j.fob.2015.06.010  1
2014 Chee SM, Wongsantichon J, Soo Tng Q, Robinson R, Joseph TL, Verma C, Lane DP, Brown CJ, Ghadessy FJ. Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2. Plos One. 9: e104914. PMID 25115702 DOI: 10.1371/journal.pone.0104914  1
2014 Sangith N, Srinivasaraghavan K, Sahu I, Desai A, Medipally S, Somavarappu AK, Verma C, Venkatraman P. Discovery of novel interacting partners of PSMD9, a proteasomal chaperone: Role of an Atypical and versatile PDZ-domain motif interaction and identification of putative functional modules. Febs Open Bio. 4: 571-83. PMID 25009770 DOI: 10.1016/j.fob.2014.05.005  1
2014 Tan YS, Spring DR, Abell C, Verma C. The use of chlorobenzene as a probe molecule in molecular dynamics simulations. Journal of Chemical Information and Modeling. 54: 1821-7. PMID 24910248 DOI: 10.1021/ci500215x  1
2014 Lau YH, de Andrade P, Sköld N, McKenzie GJ, Venkitaraman AR, Verma C, Lane DP, Spring DR. Investigating peptide sequence variations for 'double-click' stapled p53 peptides. Organic & Biomolecular Chemistry. 12: 4074-7. PMID 24817343 DOI: 10.1039/c4ob00742e  1
2014 Khoo KH, Hoe KK, Verma CS, Lane DP. Drugging the p53 pathway: understanding the route to clinical efficacy. Nature Reviews. Drug Discovery. 13: 217-36. PMID 24577402 DOI: 10.1038/nrd4236  1
2014 Lakshminarayanan R, Liu S, Li J, Nandhakumar M, Aung TT, Goh E, Chang JYT, Saraswathi P, Tang C, Safie SRB, Lin LY, Riezman H, Lei Z, Verma CS, Beuerman RW. Synthetic multivalent antifungal peptides effective against fungi Plos One. 9. PMID 24498363 DOI: 10.1371/journal.pone.0087730  1
2014 Goh WL, Lee MY, Joseph TL, Quah ST, Brown CJ, Verma C, Brenner S, Ghadessy FJ, Teo YN. Molecular rotors as conditionally fluorescent labels for rapid detection of biomolecular interactions. Journal of the American Chemical Society. 136: 6159-62. PMID 24494589 DOI: 10.1021/ja413031h  1
2014 Lukman S, Verma CS, Fuentes G. Exploiting protein intrinsic flexibility in drug design. Advances in Experimental Medicine and Biology. 805: 245-69. PMID 24446365 DOI: 10.1007/978-3-319-02970-2_11  1
2014 Lau YH, De Andrade P, Quah ST, Rossmann M, Laraia L, Sköld N, Sum TJ, Rowling PJE, Joseph TL, Verma C, Hyvönen M, Itzhaki LS, Venkitaraman AR, Brown CJ, Lane DP, et al. Functionalised staple linkages for modulating the cellular activity of stapled peptides Chemical Science. 5: 1804-1809. DOI: 10.1039/c4sc00045e  1
2014 Sim AYL, Joseph T, Lane DP, Verma C. Mechanism of stapled peptide binding to MDM2: Possible consequences for peptide design Journal of Chemical Theory and Computation. 10: 1753-1761. DOI: 10.1021/ct4009238  1
2013 Lukman S, Lane DP, Verma CS. Mapping the structural and dynamical features of multiple p53 DNA binding domains: insights into loop 1 intrinsic dynamics. Plos One. 8: e80221. PMID 24324553 DOI: 10.1371/journal.pone.0080221  0.6
2013 Wei SJ, Joseph T, Chee S, Li L, Yurlova L, Zolghadr K, Brown C, Lane D, Verma C, Ghadessy F. Inhibition of nutlin-resistant HDM2 mutants by stapled peptides. Plos One. 8: e81068. PMID 24278380 DOI: 10.1371/journal.pone.0081068  1
2013 Pereira M, Verma CS, Fuentes G. Differences in the binding affinities of ErbB family: heterogeneity in the prediction of resistance mutants. Plos One. 8: e77054. PMID 24194858 DOI: 10.1371/journal.pone.0077054  1
2013 Maity A, Yadav S, Verma CS, Ghosh Dastidar S. Dynamics of Bcl-xL in water and membrane: molecular simulations. Plos One. 8: e76837. PMID 24116174 DOI: 10.1371/journal.pone.0076837  1
2013 Hernychova L, Man P, Verma C, Nicholson J, Sharma CA, Ruckova E, Teo JY, Ball K, Vojtesek B, Hupp TR. Identification of a second Nutlin-3 responsive interaction site in the N-terminal domain of MDM2 using hydrogen/deuterium exchange mass spectrometry. Proteomics. 13: 2512-25. PMID 23776060 DOI: 10.1002/pmic.201300029  1
2013 Wei SJ, Joseph T, Sim AY, Yurlova L, Zolghadr K, Lane D, Verma C, Ghadessy F. In vitro selection of mutant HDM2 resistant to Nutlin inhibition. Plos One. 8: e62564. PMID 23653682 DOI: 10.1371/journal.pone.0062564  1
2013 ElSawy KM, Verma CS, Joseph TL, Lane DP, Twarock R, Caves LS. On the interaction mechanisms of a p53 peptide and nutlin with the MDM2 and MDMX proteins: a Brownian dynamics study. Cell Cycle (Georgetown, Tex.). 12: 394-404. PMID 23324352 DOI: 10.4161/cc.23511  1
2013 Kreisberg JF, Ong NT, Krishna A, Joseph TL, Wang J, Ong C, Ooi HA, Sung JC, Siew CC, Chang GC, Biot F, Cuccui J, Wren BW, Chan J, Sivalingam SP, ... ... Verma C, et al. Growth inhibition of pathogenic bacteria by sulfonylurea herbicides. Antimicrobial Agents and Chemotherapy. 57: 1513-7. PMID 23263008 DOI: 10.1128/AAC.02327-12  1
2013 Brown CJ, Quah ST, Jong J, Goh AM, Chiam PC, Khoo KH, Choong ML, Lee MA, Yurlova L, Zolghadr K, Joseph TL, Verma CS, Lane DP. Stapled peptides with improved potency and specificity that activate p53. Acs Chemical Biology. 8: 506-12. PMID 23214419 DOI: 10.1021/cb3005148  1
2012 Vinekar R, Verma C, Ghosh I. Functional relevance of dynamic properties of Dimeric NADP-dependent Isocitrate Dehydrogenases. Bmc Bioinformatics. 13: S2. PMID 23281650 DOI: 10.1186/1471-2105-13-S17-S2  1
2012 Zhou W, Quah ST, Verma CS, Liu Y, Lane DP, Brown CJ. Improved eIF4E binding peptides by phage display guided design: plasticity of interacting surfaces yield collective effects. Plos One. 7: e47235. PMID 23094039 DOI: 10.1371/journal.pone.0047235  0.4
2012 Joseph TL, Lane DP, Verma CS. Stapled BH3 peptides against MCL-1: mechanism and design using atomistic simulations. Plos One. 7: e43985. PMID 22952838 DOI: 10.1371/journal.pone.0043985  1
2012 Zhou W, Motakis E, Fuentes G, Verma CS. Macrostate identification from biomolecular simulations through time series analysis. Journal of Chemical Information and Modeling. 52: 2319-24. PMID 22928709 DOI: 10.1021/ci300341v  1
2012 Dastidar SG, Lane DP, Verma CS. Why is F19Ap53 unable to bind MDM2? Simulations suggest crack propagation modulates binding. Cell Cycle (Georgetown, Tex.). 11: 2239-47. PMID 22617389 DOI: 10.4161/cc.20333  0.56
2012 Sonkaria S, Fuentes G, Verma C, Narang R, Khare V, Fischer A, Faivre D. Insight into the assembly properties and functional organisation of the magnetotactic bacterial actin-like homolog, MamK. Plos One. 7: e34189. PMID 22586444 DOI: 10.1371/journal.pone.0034189  1
2012 Raghunathan D, Gayen S, Kumar A, Hunke C, Grüber G, Verma CS. Subunit F modulates ATP binding and migration in the nucleotide-binding subunit B of the A 1A O ATP synthase of Methanosarcina mazei Gö1 Journal of Bioenergetics and Biomembranes. 44: 213-224. PMID 22350011 DOI: 10.1007/s10863-012-9410-y  1
2012 Lukman S, Robinson RC, Wales D, Verma CS. Conformational dynamics of capping protein and interaction partners: simulation studies. Proteins. 80: 1066-77. PMID 22253039 DOI: 10.1002/prot.24008  1
2011 Lane DP, Madhumalar A, Lee AP, Tay BH, Verma C, Brenner S, Venkatesh B. Conservation of all three p53 family members and Mdm2 and Mdm4 in the cartilaginous fish. Cell Cycle (Georgetown, Tex.). 10: 4272-9. PMID 22107961 DOI: 10.4161/cc.10.24.18567  1
2011 Brown CJ, Dastidar SG, Quah ST, Lim A, Chia B, Verma CS. C-terminal substitution of MDM2 interacting peptides modulates binding affinity by distinctive mechanisms. Plos One. 6: e24122. PMID 21904608 DOI: 10.1371/journal.pone.0024122  1
2011 Fuentes G, Scaltriti M, Baselga J, Verma CS. Synergy between trastuzumab and pertuzumab for human epidermal growth factor 2 (Her2) from colocalization: an in silico based mechanism. Breast Cancer Research : Bcr. 13: R54. PMID 21600050 DOI: 10.1186/bcr2888  1
2011 Tan YS, Fuentes G, Verma C. A comparison of the dynamics of pantothenate synthetase from M. tuberculosis and E. coli: computational studies. Proteins. 79: 1715-27. PMID 21425349 DOI: 10.1002/prot.22994  1
2011 Goudie DR, D'Alessandro M, Merriman B, Lee H, Szeverényi I, Avery S, O'Connor BD, Nelson SF, Coats SE, Stewart A, Christie L, Pichert G, Friedel J, Hayes I, Burrows N, ... ... Verma C, et al. Multiple self-healing squamous epithelioma is caused by a disease-specific spectrum of mutations in TGFBR1. Nature Genetics. 43: 365-9. PMID 21358634 DOI: 10.1038/ng.780  1
2011 Dastidar SG, Raghunathan D, Nicholson J, Hupp TR, Lane DP, Verma CS. Chemical states of the N-terminal "lid" of MDM2 regulate p53 binding: simulations reveal complexities of modulation. Cell Cycle (Georgetown, Tex.). 10: 82-9. PMID 21191186 DOI: 10.4161/cc.10.1.14345  1
2011 Brown CJ, Lim JJ, Leonard T, Lim HC, Chia CS, Verma CS, Lane DP. Stabilizing the eIF4G1 α-helix increases its binding affinity with eIF4E: implications for peptidomimetic design strategies. Journal of Molecular Biology. 405: 736-53. PMID 21094167 DOI: 10.1016/j.jmb.2010.10.045  1
2011 Cheok CF, Verma CS, Baselga J, Lane DP. Translating p53 into the clinic. Nature Reviews. Clinical Oncology. 8: 25-37. PMID 20975744 DOI: 10.1038/nrclinonc.2010.174  0.36
2011 Medda F, Joseph TL, Pirrie L, Higgins M, Slawin AMZ, Lain S, Verma C, Westwood NJ. N1-Benzyl substituted cambinol analogues as isozyme selective inhibitors of the sirtuin family of protein deacetylases Medchemcomm. 2: 611-615. DOI: 10.1039/c1md00023c  1
2011 Fuentes G, Dastidar SG, Madhumalar A, Verma CS. Role of protein flexibility in the discovery of new drugs Drug Development Research. 72: 26-35. DOI: 10.1002/ddr.20399  1
2010 Pennell S, Westcott S, Ortiz-Lombardía M, Patel D, Li J, Nott TJ, Mohammed D, Buxton RS, Yaffe MB, Verma C, Smerdon SJ. Structural and functional analysis of phosphothreonine-dependent FHA domain interactions. Structure (London, England : 1993). 18: 1587-95. PMID 21134638 DOI: 10.1016/j.str.2010.09.014  1
2010 Fraser JA, Madhumalar A, Blackburn E, Bramham J, Walkinshaw MD, Verma C, Hupp TR. A novel p53 phosphorylation site within the MDM2 ubiquitination signal: II. A model in which phosphorylation at Ser269 induces a mutant conformation to p53 Journal of Biological Chemistry. 285: 37773-37786. PMID 20847049 DOI: 10.1074/jbc.M110.143107  1
2010 Ng YW, Raghunathan D, Chan PM, Baskaran Y, Smith DJ, Lee CH, Verma C, Manser E. Why an A-loop phospho-mimetic fails to activate PAK1: understanding an inaccessible kinase state by molecular dynamics simulations. Structure (London, England : 1993). 18: 879-90. PMID 20637424 DOI: 10.1016/j.str.2010.04.011  1
2010 Grüber G, Raghunathan D, Gayen S, Verma CS. Crosstalk along the stalk: Dynamics of the interaction of subunits B and F in the A1AO ATP synthase of methanosarcina mazei Gö1 Biochemistry. 49: 4181-4190. PMID 20377205 DOI: 10.1021/bi9021236  1
2010 Joseph TL, Madhumalar A, Brown CJ, Lane DP, Verma CS. Differential binding of p53 and nutlin to MDM2 and MDMX: computational studies. Cell Cycle (Georgetown, Tex.). 9: 1167-81. PMID 20190571  0.56
2010 Lane DP, Cheok CF, Brown CJ, Madhumalar A, Ghadessy FJ, Verma C. The Mdm2 and p53 genes are conserved in the Arachnids. Cell Cycle (Georgetown, Tex.). 9: 748-54. PMID 20160485  0.56
2010 Mavinahalli JN, Madhumalar A, Beuerman RW, Lane DP, Verma C. Differences in the transactivation domains of p53 family members: a computational study. Bmc Genomics. 11: S5. PMID 20158876 DOI: 10.1186/1471-2164-11-S1-S5  0.56
2010 Lane DP, Cheok CF, Brown C, Madhumalar A, Ghadessy FJ, Verma C. Mdm2 and p53 are highly conserved from placozoans to man. Cell Cycle (Georgetown, Tex.). 9: 540-7. PMID 20081368  0.56
2010 Brown CJ, Dastidar SG, See HY, Coomber DW, Ortiz-Lombardía M, Verma C, Lane DP. Rational design and biophysical characterization of thioredoxin-based aptamers: insights into peptide grafting. Journal of Molecular Biology. 395: 871-83. PMID 19895821 DOI: 10.1016/j.jmb.2009.10.069  0.56
2009 Dastidar SG, Lane DP, Verma CS. Modulation of p53 binding to MDM2: computational studies reveal important roles of Tyr100. Bmc Bioinformatics. 10: S6. PMID 19958516 DOI: 10.1186/1471-2105-10-S15-S6  0.56
2009 Brown CJ, Lain S, Verma CS, Fersht AR, Lane DP. Awakening guardian angels: drugging the p53 pathway. Nature Reviews. Cancer. 9: 862-73. PMID 19935675 DOI: 10.1038/nrc2763  1
2009 Madhumalar A, Lee HJ, Brown CJ, Lane D, Verma C. Design of a novel MDM2 binding peptide based on the p53 family. Cell Cycle (Georgetown, Tex.). 8: 2828-36. PMID 19713735  1
2009 Liu S, Zhou L, Chen L, Dastidar SG, Verma C, Li J, Tan D, Beuerman R. Effect of structural parameters of peptides on dimer formation and highly oxidized side products in the oxidation of thiols of linear analogues of human beta-defensin 3 by DMSO. Journal of Peptide Science : An Official Publication of the European Peptide Society. 15: 95-106. PMID 19108000 DOI: 10.1002/psc.1100  0.56
2009 Madhumalar A, Jun LH, Lane DP, Verma CS. Dimerization of the core domain of the p53 family: a computational study. Cell Cycle (Georgetown, Tex.). 8: 137-48. PMID 19106606  0.56
2008 Dastidar SG, Lane DP, Verma CS. Multiple peptide conformations give rise to similar binding affinities: molecular simulations of p53-MDM2. Journal of the American Chemical Society. 130: 13514-5. PMID 18800837 DOI: 10.1021/ja804289g  0.56
2008 Liu S, Zhou L, Li J, Suresh A, Verma C, Foo YH, Yap EP, Tan DT, Beuerman RW. Linear analogues of human beta-defensin 3: concepts for design of antimicrobial peptides with reduced cytotoxicity to mammalian cells. Chembiochem : a European Journal of Chemical Biology. 9: 964-73. PMID 18350527 DOI: 10.1002/cbic.200700560  1
2008 Madhumalar A, Smith DJ, Verma C. Stability of the core domain of p53: insights from computer simulations. Bmc Bioinformatics. 9: S17. PMID 18315848 DOI: 10.1186/1471-2105-9-S1-S17  0.56
2007 Verma C, Seebah S, Low SM, Zhou L, Liu SP, Li J, Beuerman RW. Defensins: Antimicrobial peptides for therapeutic development Biotechnology Journal. 2: 1353-1359. PMID 17886240 DOI: 10.1002/biot.200700148  1
2007 Fuentes G, Ballesteros A, Verma CS. Enthalpic and entropic contributions in the transesterification of sucrose: computational study of lipases and subtilisin. Journal of Biomolecular Structure & Dynamics. 25: 145-55. PMID 17718593 DOI: 10.1080/07391102.2007.10507163  1
2007 Hill CL, Lee CH, Smith DJ, Verma CS, Grogan G. On the resolution of chiral substrates by a retro-Claisenase enzyme: Biotransformations of heteroannular bicyclic β-diketones by 6-oxocamphor hydrolase Advanced Synthesis and Catalysis. 349: 1353-1360. DOI: 10.1002/adsc.200700046  1
2007 Hill CL, Verma CS, Grogan G. Desymmetrisations of 1-alkylbicyclo[3.3.0]octane-2,8-diones by enzymatic retro-Claisen reaction yield optically enriched 2,3-substituted cyclopentanones Advanced Synthesis and Catalysis. 349: 916-924. DOI: 10.1002/adsc.200600468  1
2006 Suresh A, Verma C. Modelling study of dimerization in mammalian defensins. Bmc Bioinformatics. 7: S17. PMID 17254301 DOI: 10.1186/1471-2105-7-S5-S17  1
2006 Lim WG, Tan BJ, Zhu Y, Zhou S, Armstrong JS, Li QT, Dong Q, Chan E, Smith D, Verma C, Tan SL, Duan W. The very C-terminus of PRK1/PKN is essential for its activation by RhoA and downstream signaling. Cellular Signalling. 18: 1473-81. PMID 16427251 DOI: 10.1016/j.cellsig.2005.11.009  1
2006 Zhu Y, Smith D, Verma C, Lim WG, Tan BJ, Armstrong JS, Zhou S, Chan E, Tan SL, Zhu YZ, Cheung NS, Duan W. The very C-terminus of protein kinase Cepsilon is critical for the full catalytic competence but its hydrophobic motif is dispensable for the interaction with 3-phosphoinositide-dependent kinase-1. Cellular Signalling. 18: 807-18. PMID 16137858 DOI: 10.1016/j.cellsig.2005.07.005  1
2004 Fuentes G, Ballesteros A, Verma CS. Specificity in lipases: a computational study of transesterification of sucrose. Protein Science : a Publication of the Protein Society. 13: 3092-103. PMID 15557256 DOI: 10.1110/ps.04724504  1
2004 Haire LF, Whyte SM, Vasisht N, Gill AC, Verma C, Dodson EJ, Dodson GG, Bayley PM. The crystal structure of the globular domain of sheep prion protein. Journal of Molecular Biology. 336: 1175-83. PMID 15037077 DOI: 10.1016/j.jmb.2003.12.059  1
2004 Prabhakaran M, Gursahani SH, Verma CS, Garduno-Juarez R, Renugopalakrishnan V. Cytochrome c: The effect of temperature and pressure from molecular dynamics simulations Journal of Physics and Chemistry of Solids. 65: 1615-1622. DOI: 10.1016/j.jpcs.2003.10.079  1
2002 Fuentes G, Cruces MA, Plou FJ, Ballesteros A, Verma CS. Computational studies of subtilisin-catalyzed transesterification of sucrose: importance of entropic effects. Chembiochem : a European Journal of Chemical Biology. 3: 907-10. PMID 12210994 DOI: 10.1002/1439-7633(20020902)3:9<907::AID-CBIC907>3.0.CO;2-6  1
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