Klaus Rajewsky - Publications

Affiliations: 
Genetics University of Cologne, Köln, Nordrhein-Westfalen, Germany 
Area:
Molecular genetics
Website:
http://de.wikipedia.org/wiki/Klaus_Rajewsky

199 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Cho S, Wu CJ, Yasuda T, Cruz LO, Khan AA, Lin LL, Nguyen DT, Miller M, Lee HM, Kuo ML, Broide DH, Rajewsky K, Rudensky AY, Lu LF. miR-23∼27∼24 clusters control effector T cell differentiation and function. The Journal of Experimental Medicine. PMID 26834155 DOI: 10.1084/jem.20150990  0.88
2016 Farber DL, Netea MG, Radbruch A, Rajewsky K, Zinkernagel RM. Immunological memory: lessons from the past and a look to the future. Nature Reviews. Immunology. 16: 124-8. PMID 26831526 DOI: 10.1038/nri.2016.13  0.88
2016 Chu VT, Weber T, Graf R, Sommermann T, Petsch K, Sack U, Volchkov P, Rajewsky K, Kühn R. Efficient generation of Rosa26 knock-in mice using CRISPR/Cas9 in C57BL/6 zygotes. Bmc Biotechnology. 16: 4. PMID 26772810 DOI: 10.1186/s12896-016-0234-4  0.88
2016 Wilhelm K, Happel K, Eelen G, Schoors S, Oellerich MF, Lim R, Zimmermann B, Aspalter IM, Franco CA, Boettger T, Braun T, Fruttiger M, Rajewsky K, Keller C, Brüning JC, et al. FOXO1 couples metabolic activity and growth state in the vascular endothelium. Nature. PMID 26735015 DOI: 10.1038/nature16498  0.88
2015 Sander S, Chu VT, Yasuda T, Franklin A, Graf R, Calado DP, Li S, Imami K, Selbach M, Di Virgilio M, Bullinger L, Rajewsky K. PI3 Kinase and FOXO1 Transcription Factor Activity Differentially Control B Cells in the Germinal Center Light and Dark Zones. Immunity. PMID 26620760 DOI: 10.1016/j.immuni.2015.10.021  0.88
2015 Akilli Öztürk Ö, Pakula H, Chmielowiec J, Qi J, Stein S, Lan L, Sasaki Y, Rajewsky K, Birchmeier W. Gab1 and Mapk Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence. Cell Reports. 13: 561-72. PMID 26456821 DOI: 10.1016/j.celrep.2015.09.015  0.88
2015 Otipoby KL, Waisman A, Derudder E, Srinivasan L, Franklin A, Rajewsky K. The B-cell antigen receptor integrates adaptive and innate immune signals. Proceedings of the National Academy of Sciences of the United States of America. 112: 12145-50. PMID 26371314 DOI: 10.1073/pnas.1516428112  0.88
2015 Budeus B, Schweigle de Reynoso S, Przekopowitz M, Hoffmann D, Seifert M, Küppers R. Complexity of the human memory B-cell compartment is determined by the versatility of clonal diversification in germinal centers. Proceedings of the National Academy of Sciences of the United States of America. 112: E5281-9. PMID 26324941 DOI: 10.1073/pnas.1511270112  0.88
2015 Ba Z, Meng FL, Gostissa M, Huang PY, Ke Q, Wang Z, Dao MN, Fujiwara Y, Rajewsky K, Zhang B, Alt FW. A Rapid Embryonic Stem Cell-Based Mouse Model for B-cell Lymphomas Driven by Epstein-Barr Virus Protein LMP1. Cancer Immunology Research. 3: 641-9. PMID 25934172 DOI: 10.1158/2326-6066.CIR-15-0058  0.88
2015 Zhang B, Calado DP, Wang Z, Fröhler S, Köchert K, Qian Y, Koralov SB, Schmidt-Supprian M, Sasaki Y, Unitt C, Rodig S, Chen W, Dalla-Favera R, Alt FW, Pasqualucci L, ... Rajewsky K, et al. An oncogenic role for alternative NF-κB signaling in DLBCL revealed upon deregulated BCL6 expression. Cell Reports. 11: 715-26. PMID 25921526 DOI: 10.1016/j.celrep.2015.03.059  0.88
2015 Chu VT, Weber T, Wefers B, Wurst W, Sander S, Rajewsky K, Kühn R. Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells. Nature Biotechnology. 33: 543-8. PMID 25803306 DOI: 10.1038/nbt.3198  0.88
2015 Rajewsky K. The DNA deamination model of somatic antibody diversification Journal of Immunology. 194: 2041-2042. PMID 25710956 DOI: 10.4049/jimmunol.1403252  0.88
2015 Ko M, An J, Pastor WA, Koralov SB, Rajewsky K, Rao A. TET proteins and 5-methylcytosine oxidation in hematological cancers. Immunological Reviews. 263: 6-21. PMID 25510268 DOI: 10.1111/imr.12239  0.88
2015 Rajewsky K. The Herzenberg lecture: How to make a B-1 cell? Annals of the New York Academy of Sciences. DOI: 10.1111/nyas.12767  0.88
2014 Kreher S, Bouhlel MA, Cauchy P, Lamprecht B, Li S, Grau M, Hummel F, Köchert K, Anagnostopoulos I, Jöhrens K, Hummel M, Hiscott J, Wenzel SS, Lenz P, Schneider M, ... ... Rajewsky K, et al. Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma. Proceedings of the National Academy of Sciences of the United States of America. 111: E4513-22. PMID 25288773 DOI: 10.1073/pnas.1406985111  0.88
2014 Backert I, Koralov SB, Wirtz S, Kitowski V, Billmeier U, Martini E, Hofmann K, Hildner K, Wittkopf N, Brecht K, Waldner M, Rajewsky K, Neurath MF, Becker C, Neufert C. STAT3 activation in Th17 and Th22 cells controls IL-22-mediated epithelial host defense during infectious colitis. Journal of Immunology (Baltimore, Md. : 1950). 193: 3779-91. PMID 25187663 DOI: 10.4049/jimmunol.1303076  0.88
2014 Hojer C, Frankenberger S, Strobl LJ, Feicht S, Djermanovic K, Jagdhuber F, Hömig-Hölzel C, Ferch U, Ruland J, Rajewsky K, Zimber-Strobl U. B-cell expansion and lymphomagenesis induced by chronic CD40 signaling is strictly dependent on CD19. Cancer Research. 74: 4318-28. PMID 24938766 DOI: 10.1158/0008-5472.CAN-13-3274  0.88
2014 Takemori T, Kaji T, Takahashi Y, Shimoda M, Rajewsky K. Generation of memory B cells inside and outside germinal centers European Journal of Immunology. 44: 1258-1264. PMID 24610726 DOI: 10.1002/eji.201343716  0.88
2014 Heuberger J, Kosel F, Qi J, Grossmann KS, Rajewsky K, Birchmeier W. Shp2/MAPK signaling controls goblet/paneth cell fate decisions in the intestine Proceedings of the National Academy of Sciences of the United States of America. 111: 3472-3477. PMID 24550486 DOI: 10.1073/pnas.1309342111  0.88
2014 Rajewsky K. Michael S. Neuberger 1953-2013. Proceedings of the National Academy of Sciences of the United States of America. 111: 2862-2863. PMID 24532658  0.88
2014 Sheean ME, McShane E, Cheret C, Walcher J, Müller T, Wulf-Goldenberg A, Hoelper S, Garratt AN, Krüger M, Rajewsky K, Meijer D, Birchmeier W, Lewin GR, Selbach M, Birchmeier C. Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination. Genes & Development. 28: 290-303. PMID 24493648 DOI: 10.1101/gad.230045.113  0.88
2014 Colombo E, Tentorio P, Musio S, Rajewsky K, Pedotti R, Casola S, Farina C. Skewed B cell differentiation affects lymphoid organogenesis but not T cell-mediated autoimmunity. Clinical and Experimental Immunology. 176: 58-65. PMID 24325711 DOI: 10.1111/cei.12250  0.88
2014 Muljo SA, Rajewsky K. Roles of MicroRNAs in B Lymphocyte Physiology and Oncogenesis Molecular Biology of B Cells: Second Edition. 65-73. DOI: 10.1016/B978-0-12-397933-9.00005-9  0.88
2013 Yasuda T, Wirtz T, Zhang B, Wunderlich T, Schmidt-Supprian M, Sommermann T, Rajewsky K. Studying Epstein-Barr virus pathologies and immune surveillance by reconstructing EBV infection in mice Cold Spring Harbor Symposia On Quantitative Biology. 78: 259-263. PMID 24241423 DOI: 10.1101/sqb.2013.78.020222  0.88
2013 Kreslavsky T, Kim HJ, Koralov SB, Ghitza D, Buch T, Cantor H, Rajewsky K, Von Boehmer H. Negative selection, not receptor editing, is a physiological response of autoreactive thymocytes Journal of Experimental Medicine. 210: 1911-1918. PMID 23980099 DOI: 10.1084/jem.20130876  0.88
2013 Fogli LK, Sundrud MS, Goel S, Bajwa S, Jensen K, Derudder E, Sun A, Coffre M, Uyttenhove C, Van Snick J, Schmidt-Supprian M, Rao A, Grunig G, Durbin J, Casola S, ... ... Rajewsky K, et al. T cell-derived IL-17 mediates epithelial changes in the airway and drives pulmonary neutrophilia. Journal of Immunology (Baltimore, Md. : 1950). 191: 3100-11. PMID 23966625 DOI: 10.4049/jimmunol.1301360  0.88
2013 Jin HY, Oda H, Lai M, Skalsky RL, Bethel K, Shepherd J, Kang SG, Liu WH, Sabouri-Ghomi M, Cullen BR, Rajewsky K, Xiao C. MicroRNA-17∼92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways Embo Journal. 32: 2377-2391. PMID 23921550 DOI: 10.1038/emboj.2013.178  0.88
2013 Gu H, Zou YR, Rajewsky K. Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Journal of Immunology (Baltimore, Md. : 1950). 191: 7-16. PMID 23794701  0.88
2013 Wang D, Höing S, Patterson HC, Ahmad UM, Rathinam VA, Rajewsky K, Fitzgerald KA, Golenbock DT. Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins. The Journal of Biological Chemistry. 288: 4594-601. PMID 23293022 DOI: 10.1074/jbc.M112.443077  0.88
2013 Rajewsky K. Years in cologne Annual Review of Immunology. 31: 1-29. PMID 23140542 DOI: 10.1146/annurev.immunol.021908.132646  0.88
2012 Derecka M, Gornicka A, Koralov SB, Szczepanek K, Morgan M, Raje V, Sisler J, Zhang Q, Otero D, Cichy J, Rajewsky K, Shimoda K, Poli V, Strobl B, Pellegrini S, et al. Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity. Cell Metabolism. 16: 814-24. PMID 23217260 DOI: 10.1016/j.cmet.2012.11.005  0.88
2012 Sander S, Rajewsky K. Burkitt lymphomagenesis linked to MYC plus PI3K in germinal center B cells Oncotarget. 3: 1066-1067. PMID 23164662  0.88
2012 Kaji T, Ishige A, Hikida M, Taka J, Hijikata A, Kubo M, Nagashima T, Takahashi Y, Kurosaki T, Okada M, Ohara O, Rajewsky K, Takemori T. Distinct cellular pathways select germlineencoded and somatically mutated antibodies into immunological memory Journal of Experimental Medicine. 209: 2079-2097. PMID 23027924 DOI: 10.1084/jem.20120127  0.88
2012 Calado DP, Sasaki Y, Godinho SA, Pellerin A, Köchert K, Sleckman BP, De Alborán IM, Janz M, Rodig S, Rajewsky K. The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers Nature Immunology. 13: 1092-1100. PMID 23001146 DOI: 10.1038/ni.2418  0.88
2012 Sander S, Calado DP, Srinivasan L, Köchert K, Zhang B, Rosolowski M, Rodig SJ, Holzmann K, Stilgenbauer S, Siebert R, Bullinger L, Rajewsky K. Synergy between PI3K Signaling and MYC in Burkitt Lymphomagenesis Cancer Cell. 22: 167-179. PMID 22897848 DOI: 10.1016/j.ccr.2012.06.012  0.88
2012 Zhang B, Kracker S, Yasuda T, Casola S, Vanneman M, Hömig-Hölzel C, Wang Z, Derudder E, Li S, Chakraborty T, Cotter SE, Koyama S, Currie T, Freeman GJ, Kutok JL, ... ... Rajewsky K, et al. Immune surveillance and therapy of lymphomas driven by Epstein-Barr virus protein LMP1 in a mouse model. Cell. 148: 739-51. PMID 22341446 DOI: 10.1016/j.cell.2011.12.031  0.88
2012 Dagan LN, Jiang X, Bhatt S, Cubedo E, Rajewsky K, Lossos IS. miR-155 regulates HGAL expression and increases lymphoma cell motility Blood. 119: 513-520. PMID 22096245 DOI: 10.1182/blood-2011-08-370536  0.88
2011 McCulloch L, Brown KL, Bradford BM, Hopkins J, Bailey M, Rajewsky K, Manson JC, Mabbott NA. Follicular dendritic cell-specific prion protein (PrP) expression alone is sufficient to sustain prion infection in the spleen. Plos Pathogens. 7: e1002402. PMID 22144895 DOI: 10.1371/journal.ppat.1002402  0.88
2011 Wesemann DR, Magee JM, Boboila C, Calado DP, Gallagher MP, Portuguese AJ, Manis JP, Zhou X, Recher M, Rajewsky K, Notarangelo LD, Alt FW. Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination. The Journal of Experimental Medicine. 208: 2733-46. PMID 22143888 DOI: 10.1084/jem.20111155  0.88
2011 Ko M, Bandukwala HS, An J, Lamperti ED, Thompson EC, Hastie R, Tsangaratou A, Rajewsky K, Koralov SB, Rao A. Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice. Proceedings of the National Academy of Sciences of the United States of America. 108: 14566-71. PMID 21873190 DOI: 10.1073/pnas.1112317108  0.88
2011 Patterson HC, Kraus M, Wang D, Shahsafaei A, Henderson JM, Seagal J, Otipoby KL, Thai TH, Rajewsky K. Cytoplasmic Ig alpha serine/threonines fine-tune Ig alpha tyrosine phosphorylation and limit bone marrow plasma cell formation. Journal of Immunology (Baltimore, Md. : 1950). 187: 2853-8. PMID 21841126 DOI: 10.4049/jimmunol.1101143  0.88
2011 Arnaout R, Lee W, Cahill P, Honan T, Sparrow T, Weiand M, Nusbaum C, Rajewsky K, Koralov SB. High-resolution description of antibody heavy-chain repertoires in humans. Plos One. 6: e22365. PMID 21829618 DOI: 10.1371/journal.pone.0022365  0.88
2011 Kometani K, Yamada T, Sasaki Y, Yokosuka T, Saito T, Rajewsky K, Ishiai M, Hikida M, Kurosaki T. CIN85 drives B cell responses by linking BCR signals to the canonical NF-κB pathway Journal of Experimental Medicine. 208: 1447-1457. PMID 21708930 DOI: 10.1084/jem.20102665  0.88
2011 Vlantis K, Wullaert A, Sasaki Y, Schmidt-Supprian M, Rajewsky K, Roskams T, Pasparakis M. Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice Journal of Clinical Investigation. 121: 2781-2793. PMID 21701067 DOI: 10.1172/JCI45349  0.88
2011 Eschbach C, Bach MP, Fidler I, Pelanda R, Köhler F, Rajewsky K, Jumaa H. Efficient generation of B lymphocytes by recognition of self-antigens. European Journal of Immunology. 41: 2397-403. PMID 21604259 DOI: 10.1002/eji.201041344  0.88
2011 Green MR, Monti S, Dalla-Favera R, Pasqualucci L, Walsh NC, Schmidt-Supprian M, Kutok JL, Rodig SJ, Neuberg DS, Rajewsky K, Golub TR, Alt FW, Shipp MA, Manis JP. Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program. Proceedings of the National Academy of Sciences of the United States of America. 108: 2873-8. PMID 21282644 DOI: 10.1073/pnas.1019537108  0.88
2010 Calado DP, Zhang B, Srinivasan L, Sasaki Y, Seagal J, Unitt C, Rodig S, Kutok J, Tarakhovsky A, Schmidt-Supprian M, Rajewsky K. Constitutive Canonical NF-κB Activation Cooperates with Disruption of BLIMP1 in the Pathogenesis of Activated B Cell-like Diffuse Large Cell Lymphoma Cancer Cell. 18: 580-589. PMID 21156282 DOI: 10.1016/j.ccr.2010.11.024  0.88
2010 Mandelbaum J, Bhagat G, Tang H, Mo T, Brahmachary M, Shen Q, Chadburn A, Rajewsky K, Tarakhovsky A, Pasqualucci L, Dalla-Favera R. BLIMP1 Is a Tumor Suppressor Gene Frequently Disrupted in Activated B Cell-like Diffuse Large B Cell Lymphoma Cancer Cell. 18: 568-579. PMID 21156281 DOI: 10.1016/j.ccr.2010.10.030  0.88
2010 Espinosa L, Cathelin S, D'Altri T, Trimarchi T, Statnikov A, Guiu J, Rodilla V, Inglés-Esteve J, Nomdedeu J, Bellosillo B, Besses C, Abdel-Wahab O, Kucine N, Sun SC, Song G, ... ... Rajewsky K, et al. The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia Cancer Cell. 18: 268-281. PMID 20832754 DOI: 10.1016/j.ccr.2010.08.006  0.88
2010 Ghosh S, Koralov SB, Stevanovic I, Sundrud MS, Sasaki Y, Rajewsky K, Rao A, Müller MR. Hyperactivation of nuclear factor of activated T cells 1 (NFAT1) in T cells attenuates severity of murine autoimmune encephalomyelitis Proceedings of the National Academy of Sciences of the United States of America. 107: 15169-15174. PMID 20696888 DOI: 10.1073/pnas.1009193107  0.88
2010 Kuchen S, Resch W, Yamane A, Kuo N, Li Z, Chakraborty T, Wei L, Laurence A, Yasuda T, Peng S, Hu-Li J, Lu K, Dubois W, Kitamura Y, Charles N, ... ... Rajewsky K, et al. Regulation of microRNA expression and abundance during lymphopoiesis. Immunity. 32: 828-39. PMID 20605486 DOI: 10.1016/j.immuni.2010.05.009  0.88
2010 Kitamura D, Kudo A, Schaal S, Müller W, Melchers F, Rajewsky K. Pillars article: a critical role of lambda 5 protein in B cell development. Cell. 1992. 69: 823-831. Journal of Immunology (Baltimore, Md. : 1950). 184: 1130-8. PMID 20089708  0.88
2009 Srinivasan L, Sasaki Y, Calado DP, Zhang B, Paik JH, DePinho RA, Kutok JL, Kearney JF, Otipoby KL, Rajewsky K. PI3 kinase signals BCR-dependent mature B cell survival. Cell. 139: 573-86. PMID 19879843 DOI: 10.1016/j.cell.2009.08.041  0.88
2009 Lienenklaus S, Cornitescu M, Ziȩtara N, Łyszkiewicz M, Gekara N, Jabłońska J, Edenhofer F, Rajewsky K, Bruder D, Hafner M, Staeheli P, Weiss S. Novel reporter mouse reveals constitutive and inflammatory expression of IFN-β in vivo Journal of Immunology. 183: 3229-3236. PMID 19667093 DOI: 10.4049/jimmunol.0804277  0.88
2009 Wang JH, Gostissa M, Yan CT, Goff P, Hickernell T, Hansen E, Difilippantonio S, Wesemann DR, Zarrin AA, Rajewsky K, Nussenzweig A, Alt FW. Mechanisms promoting translocations in editing and switching peripheral B cells. Nature. 460: 231-6. PMID 19587764 DOI: 10.1038/nature08159  0.88
2009 Derudder E, Cadera EJ, Vahl JC, Wang J, Fox CJ, Zha S, van Loo G, Pasparakis M, Schlissel MS, Schmidt-Supprian M, Rajewsky K. Development of immunoglobulin λ-chain-positive B cells, but not editing of immunoglobulin κ-chain, depends on NF-κB signals Nature Immunology. 10: 647-654. PMID 19412180 DOI: 10.1038/ni.1732  0.88
2009 Müller MR, Sasaki Y, Stevanovic I, Lamperti ED, Ghosh S, Sharma S, Gelinas C, Rossi DJ, Pipkin ME, Rajewsky K, Hogan PG, Rao A. Requirement for balanced Ca/NFAT signaling in hematopoietic and embryonic development. Proceedings of the National Academy of Sciences of the United States of America. 106: 7034-9. PMID 19351896 DOI: 10.1073/pnas.0813296106  0.88
2009 Hikida M, Casola S, Takahashi N, Kaji T, Takemori T, Rajewsky K, Kurosaki T. PLC-γ 2 is essential for formation and maintenance of memory B cells Journal of Experimental Medicine. 206: 681-689. PMID 19273623 DOI: 10.1084/jem.20082100  0.88
2009 Schenten D, Kracker S, Esposito G, Franco S, Klein U, Murphy M, Alt FW, Rajewsky K. Pol zeta ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability. The Journal of Experimental Medicine. 206: 477-90. PMID 19204108 DOI: 10.1084/jem.20080669  0.88
2009 Lu LF, Thai TH, Calado DP, Chaudhry A, Kubo M, Tanaka K, Loeb GB, Lee H, Yoshimura A, Rajewsky K, Rudensky AY. Foxp3-Dependent MicroRNA155 Confers Competitive Fitness to Regulatory T Cells by Targeting SOCS1 Protein Immunity. 30: 80-91. PMID 19144316 DOI: 10.1016/j.immuni.2008.11.010  0.88
2009 Xiao C, Rajewsky K. MicroRNA control in the immune system: basic principles. Cell. 136: 26-36. PMID 19135886 DOI: 10.1016/j.cell.2008.12.027  0.88
2009 Xiao C, Rajewsky K. MicroRNA Control in the Immune System: Basic Principles (DOI:10.1016/j.cell.2008.12.027) Cell. 137: 380. DOI: 10.1016/j.cell.2009.03.022  0.88
2008 Wang JH, Alt FW, Gostissa M, Datta A, Murphy M, Alimzhanov MB, Coakley KM, Rajewsky K, Manis JP, Yan CT. Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching. The Journal of Experimental Medicine. 205: 3079-90. PMID 19064702 DOI: 10.1084/jem.20082271  0.88
2008 Zemlin M, Schelonka RL, Ippolito GC, Zemlin C, Zhuang Y, Gartland GL, Nitschke L, Pelkonen J, Rajewsky K, Schroeder HW. Regulation of repertoire development through genetic control of D H reading frame preference Journal of Immunology. 181: 8416-8424. PMID 19050259  0.88
2008 Schelonka RL, Zemlin M, Kobayashi R, Ippolito GC, Zhuang Y, Gartland GL, Szalai A, Fujihashi K, Rajewsky K, Schroeder HW. Preferential use of DH reading frame 2 alters B cell development and antigen-specific antibody production Journal of Immunology. 181: 8409-8415. PMID 19050258  0.88
2008 Hao Z, Duncan GS, Seagal J, Su YW, Hong C, Haight J, Chen NJ, Elia A, Wakeham A, Li WY, Liepa J, Wood GA, Casola S, Rajewsky K, Mak TW. Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis. Immunity. 29: 615-27. PMID 18835195 DOI: 10.1016/j.immuni.2008.07.016  0.88
2008 Otipoby KL, Sasaki Y, Schmidt-Supprian M, Patke A, Gareus R, Pasparakis M, Tarakhovsky A, Rajewsky K. BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells Proceedings of the National Academy of Sciences of the United States of America. 105: 12435-12438. PMID 18713867 DOI: 10.1073/pnas.0805460105  0.88
2008 Sasaki Y, Calado DP, Derudder E, Zhang B, Shimizu Y, Mackay F, Nishikawa SI, Rajewsky K, Schmidt-Supprian M. NIK overexpression amplifies, whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cells Proceedings of the National Academy of Sciences of the United States of America. 105: 10883-10888. PMID 18663224 DOI: 10.1073/pnas.0805186105  0.88
2008 Gwack Y, Srikanth S, Oh-Hora M, Hogan PG, Lamperti ED, Yamashita M, Gelinas C, Neems DS, Sasaki Y, Feske S, Prakriya M, Rajewsky K, Rao A. Hair loss and defective T- and B-cell function in mice lacking ORAI1. Molecular and Cellular Biology. 28: 5209-22. PMID 18591248 DOI: 10.1128/MCB.00360-08  0.88
2008 Bourgeois C, Hao Z, Rajewsky K, Potocnik AJ, Stockinger B. Ablation of thymic export causes accelerated decay of naïve CD4 T cells in the periphery because of activation by environmental antigen Proceedings of the National Academy of Sciences of the United States of America. 105: 8691-8696. PMID 18562288 DOI: 10.1073/pnas.0803732105  0.88
2008 Rajewsky K, von Boehmer H. Lymphocyte development: overview Current Opinion in Immunology. 20: 127-130. PMID 18513936 DOI: 10.1016/j.coi.2008.04.005  0.88
2008 Hömig-Hölzel C, Hojer C, Rastelli J, Casola S, Strobl LJ, Müller W, Quintanilla-Martinez L, Gewies A, Ruland J, Rajewsky K, Zimber-Strobl U. Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-κB pathway and promotes lymphomagenesis Journal of Experimental Medicine. 205: 1317-1329. PMID 18490492 DOI: 10.1084/jem.20080238  0.88
2008 Dorsett Y, McBride KM, Jankovic M, Gazumyan A, Thai TH, Robbiani DF, Di Virgilio M, San-Martin BR, Heidkamp G, Schwickert TA, Eisenreich T, Rajewsky K, Nussenzweig MC. MicroRNA-155 Suppresses Activation-Induced Cytidine Deaminase-Mediated Myc-Igh Translocation Immunity. 28: 630-638. PMID 18455451 DOI: 10.1016/j.immuni.2008.04.002  0.88
2008 Koralov SB, Muljo SA, Galler GR, Krek A, Chakraborty T, Kanellopoulou C, Jensen K, Cobb BS, Merkenschlager M, Rajewsky N, Rajewsky K. Dicer Ablation Affects Antibody Diversity and Cell Survival in the B Lymphocyte Lineage Cell. 132: 860-874. PMID 18329371 DOI: 10.1016/j.cell.2008.02.020  0.88
2008 Xiao C, Srinivasan L, Calado DP, Patterson HC, Zhang B, Wang J, Henderson JM, Kutok JL, Rajewsky K. Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes. Nature Immunology. 9: 405-14. PMID 18327259 DOI: 10.1038/ni1575  0.88
2008 Mesaros A, Koralov SB, Rother E, Wunderlich FT, Ernst MB, Barsh GS, Rajewsky K, Brüning JC. Activation of Stat3 signaling in AgRP neurons promotes locomotor activity. Cell Metabolism. 7: 236-48. PMID 18316029 DOI: 10.1016/j.cmet.2008.01.007  0.88
2008 Rastelli J, Hömig-Hölzel C, Seagal J, Müller W, Hermann AC, Rajewsky K, Zimber-Strobl U. LMP1 signaling can replace CD40 signaling in B cells in vivo and has unique features of inducing class-switch recombination to IgG1 Blood. 111: 1448-1455. PMID 18006702 DOI: 10.1182/blood-2007-10-117655  0.88
2008 Eichmann K, Avery OT, Baltimore D, Von Behring E, Benacerraf B, Bloor D, Bordet JJBV, Bona CA, Boyse EA, Burnet FM, Cantor H, Cazenave PA, Claman HN, Cohn M, Coutinho A, ... ... Rajewsky K, et al. The network collective: Rise and fall of a scientific paradigm The Network Collective: Rise and Fall of a Scientific Paradigm. 1-274. DOI: 10.1007/978-3-7643-8373-2  0.88
2007 Edry E, Koralov SB, Rajewsky K, Melamed D. Spontaneous class switch recombination in B cell lymphopoiesis generates aberrant switch junctions and is increased after VDJ rearrangement Journal of Immunology. 179: 6555-6560. PMID 17982044  0.88
2007 Rajewsky K. From a dream to reality European Journal of Immunology. 37: S134-S137. PMID 17972357 DOI: 10.1002/eji.200737819  0.88
2007 Xiao C, Calado DP, Galler G, Thai TH, Patterson HC, Wang J, Rajewsky N, Bender TP, Rajewsky K. MiR-150 Controls B Cell Differentiation by Targeting the Transcription Factor c-Myb Cell. 131: 146-159. PMID 17923094 DOI: 10.1016/j.cell.2007.07.021  0.88
2007 Yan CT, Boboila C, Souza EK, Franco S, Hickernell TR, Murphy M, Gumaste S, Geyer M, Zarrin AA, Manis JP, Rajewsky K, Alt FW. IgH class switching and translocations use a robust non-classical end-joining pathway. Nature. 449: 478-82. PMID 17713479 DOI: 10.1038/nature06020  0.88
2007 French CA, Groszer M, Preece C, Coupe AM, Rajewsky K, Fisher SE. Generation of mice with a conditional Foxp2 null allele. Genesis (New York, N.Y. : 2000). 45: 440-6. PMID 17619227 DOI: 10.1002/dvg.20305  0.88
2007 Pao LI, Lam KP, Henderson JM, Kutok JL, Alimzhanov M, Nitschke L, Thomas ML, Neel BG, Rajewsky K. B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity. Immunity. 27: 35-48. PMID 17600736 DOI: 10.1016/j.immuni.2007.04.016  0.88
2007 Schmidt-Supprian M, Rajewsky K. Vagaries of conditional gene targeting Nature Immunology. 8: 665-668. PMID 17579640 DOI: 10.1038/ni0707-665  0.88
2007 Greve B, Weissert R, Hamdi N, Bettelli E, Sobel RA, Coyle A, Kuchroo VK, Rajewsky K, Schmidt-Supprian M. I kappa B kinase 2/beta deficiency controls expansion of autoreactive T cells and suppresses experimental autoimmune encephalomyelitis. Journal of Immunology (Baltimore, Md. : 1950). 179: 179-85. PMID 17579036  0.88
2007 Fraenkel S, Mostoslavsky R, Novobrantseva TI, Pelanda R, Chaudhuri J, Esposito G, Jung S, Alt FW, Rajewsky K, Cedar H, Bergman Y. Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin kappa-chain locus. Nature Immunology. 8: 715-22. PMID 17546032 DOI: 10.1038/ni1476  0.88
2007 Schmidt-Supprian M, Wunderlich FT, Rajewsky K. Excision of the Frt-flanked neoR cassette from the CD19cre knock-in transgene reduces Cre-mediated recombination Transgenic Research. 16: 657-660. PMID 17541717 DOI: 10.1007/s11248-007-9100-4  0.88
2007 Liu H, Schmidt-Supprian M, Shi Y, Hobeika E, Barteneva N, Jumaa H, Pelanda R, Reth M, Skok J, Rajewsky K. Yin Yang 1 is a critical regulator of B-cell development Genes and Development. 21: 1179-1189. PMID 17504937 DOI: 10.1101/gad.1529307  0.88
2007 Thai TH, Calado DP, Casola S, Ansel KM, Xiao C, Xue Y, Murphy A, Frendewey D, Valenzuela D, Kutok JL, Schmidt-Supprian M, Rajewsky N, Yancopoulos G, Rao A, Rajewsky K. Regulation of the germinal center response by microRNA-155. Science (New York, N.Y.). 316: 604-8. PMID 17463289 DOI: 10.1126/science.1141229  0.88
2007 Waisman A, Kraus M, Seagal J, Ghosh S, Melamed D, Song J, Sasaki Y, Classen S, Lutz C, Brombacher F, Nitschke L, Rajewsky K. IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Ig alpha/beta. The Journal of Experimental Medicine. 204: 747-58. PMID 17420268 DOI: 10.1084/jem.20062024  0.88
2007 Sasaki Y, Schmidt-Supprian M, Derudder E, Rajewsky K. Role of NFkappaB signaling in normal and malignant B cell development. Advances in Experimental Medicine and Biology. 596: 149-154. PMID 17338183  0.88
2007 Sasaki Y, Schmidt-Supprian M, Derudder E, Rajewsky K. Role of NFκB signaling in normal and malignant B cell development Advances in Experimental Medicine and Biology. 596: 149-154. DOI: 10.1007/0-387-46530-8_13  0.88
2007 Gupta S, Alt F, Cooper M, Melchers F, Rajewsky K. Advances in Experimental Medicine and Biology: Preface Advances in Experimental Medicine and Biology. 596: vii-viii.  0.88
2006 Mora JR, Iwata M, Eksteen B, Song SY, Junt T, Senman B, Otipoby KL, Yokota A, Takeuchi H, Ricciardi-Castagnoli P, Rajewsky K, Adams DH, Von Andrian UH. Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells Science. 314: 1157-1160. PMID 17110582 DOI: 10.1126/science.1132742  0.88
2006 Feldhahn N, Schwering I, Lee S, Wartenberg M, Klein F, Wang H, Zhou G, Wang SM, Rowley JD, Hescheler J, Krönke M, Rajewsky K, Küppers R, Müschen M. Retraction. The Journal of Experimental Medicine. 203: 2779. PMID 17074927 DOI: 10.1084/jem.2002088173106c  0.88
2006 Casola S, Rajewsky K. B cell recruitment and selection in mouse GALT germinal centers Current Topics in Microbiology and Immunology. 308: 155-171. PMID 16922090  0.88
2006 Baxter FO, Came PJ, Abell K, Kedjouar B, Huth M, Rajewsky K, Pasparakis M, Watson CJ. IKKβ/2 induces TWEAK and apoptosis in mammary epithelial cells Development. 133: 3485-3494. PMID 16887827 DOI: 10.1242/dev.02502  0.88
2006 Patterson HCK, Kraus M, Kim YM, Ploegh H, Rajewsky K. The B Cell Receptor Promotes B Cell Activation and Proliferation through a Non-ITAM Tyrosine in the Igα Cytoplasmic Domain Immunity. 25: 55-65. PMID 16860757 DOI: 10.1016/j.immuni.2006.04.014  0.88
2006 Koralov SB, Novobrantseva TI, Königsmann J, Ehlich A, Rajewsky K. Antibody Repertoires Generated by VH Replacement and Direct VH to JH Joining Immunity. 25: 43-53. PMID 16860756 DOI: 10.1016/j.immuni.2006.04.016  0.88
2006 Sasaki Y, Derudder E, Hobeika E, Pelanda R, Reth M, Rajewsky K, Schmidt-Supprian M. Canonical NF-κB Activity, Dispensable for B Cell Development, Replaces BAFF-Receptor Signals and Promotes B Cell Proliferation upon Activation Immunity. 24: 729-739. PMID 16782029 DOI: 10.1016/j.immuni.2006.04.005  0.88
2006 Klein U, Casola S, Cattoretti G, Shen Q, Lia M, Mo T, Ludwig T, Rajewsky K, Dalla-Favera R. Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination Nature Immunology. 7: 773-782. PMID 16767092 DOI: 10.1038/ni1357  0.88
2006 Ippolito GC, Schelonka RL, Zemlin M, Ivanov II, Kobayashi R, Zemlin C, Gartland GL, Nitschke L, Pelkonen J, Fujihashi K, Rajewsky K, Schroeder HW. Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production Journal of Experimental Medicine. 203: 1567-1578. PMID 16754718 DOI: 10.1084/jem.20052217  0.88
2006 Casola S, Cattoretti G, Uyttersprot N, Koralov SB, Seagal J, Segal J, Hao Z, Waisman A, Egert A, Ghitza D, Rajewsky K. Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting. Proceedings of the National Academy of Sciences of the United States of America. 103: 7396-401. PMID 16651521 DOI: 10.1073/pnas.0602353103  0.88
2006 Schenten D, Egert A, Pasparakis M, Rajewsky K. M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice Blood. 107: 4849-4856. PMID 16493007 DOI: 10.1182/blood-2005-10-4154  0.88
2006 Victoratos P, Lagnel J, Tzima S, Alimzhanov MB, Rajewsky K, Pasparakis M, Kollias G. FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses Immunity. 24: 66-77. PMID 16413924 DOI: 10.1016/j.immuni.2005.11.013  0.88
2006 Nenci A, Huth M, Funteh A, Schmidt-Supprian M, Bloch W, Metzger D, Chambon P, Rajewsky K, Krieg T, Haase I, Pasparakis M. Skin lesion development in a mouse model of incontinentia pigmenti is triggered by NEMO deficiency in epidermal keratinocytes and requires TNF signaling. Human Molecular Genetics. 15: 531-42. PMID 16399796 DOI: 10.1093/hmg/ddi470  0.88
2005 Schelonka RL, Ivanov II, Jung DH, Ippolito GC, Nitschke L, Zhuang Y, Gartland GL, Pelkonen J, Alt FW, Rajewsky K, Schroeder HW. A single DH gene segment creates its own unique CDR-H3 repertoire and is sufficient for B cell development and immune function. Journal of Immunology (Baltimore, Md. : 1950). 175: 6624-32. PMID 16272317  0.88
2005 Thomas MD, Kremer CS, Ravichandran KS, Rajewsky K, Bender TP. c-Myb is critical for B cell development and maintenance of follicular B cells. Immunity. 23: 275-86. PMID 16169500 DOI: 10.1016/j.immuni.2005.08.005  0.88
2005 Monticelli S, Ansel KM, Xiao C, Socci ND, Krichevsky AM, Thai TH, Rajewsky N, Marks DS, Sander C, Rajewsky K, Rao A, Kosik KS. MicroRNA profiling of the murine hematopoietic system. Genome Biology. 6: R71. PMID 16086853 DOI: 10.1186/gb-2005-6-8-r71  0.88
2005 Muljo SA, Ansel KM, Kanellopoulou C, Livingston DM, Rao A, Rajewsky K. Aberrant T cell differentiation in the absence of Dicer. The Journal of Experimental Medicine. 202: 261-9. PMID 16009718 DOI: 10.1084/jem.20050678  0.88
2005 Oberdoerffer P, Kanellopoulou C, Heissmeyer V, Paeper C, Borowski C, Aifantis I, Rao A, Rajewsky K. Efficiency of RNA interference in the mouse hematopoietic system varies between cell types and developmental stages Molecular and Cellular Biology. 25: 3896-3905. PMID 15870264 DOI: 10.1128/MCB.25.10.3896-3905.2005  0.88
2005 Luedde T, Assmus U, Wüstefeld T, Meyer Zu Vilsendorf A, Roskams T, Schmidt-Supprian M, Rajewsky K, Brenner DA, Manns MP, Pasparakis M, Trautwein C. Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury Journal of Clinical Investigation. 115: 849-859. PMID 15776110 DOI: 10.1172/JCI200523493  0.88
2005 Tze LE, Schram BR, Lam KP, Hogquist KA, Hippen KL, Liu J, Shinton SA, Otipoby KL, Rodine PR, Vegoe AL, Kraus M, Hardy RR, Schlissel MS, Rajewsky K, Behrens TW. Basal immunoglobulin signaling actively maintains developmental stage in immature B cells. Plos Biology. 3: e82. PMID 15752064 DOI: 10.1371/journal.pbio.0030082  0.88
2005 Mandal M, Borowski C, Palomero T, Ferrando AA, Oberdoerffer P, Meng F, Ruiz-Vela A, Ciofani M, Zuniga-Pflucker JC, Screpanti I, Look AT, Korsmeyer SJ, Rajewsky K, Von Boehmer H, Aifantis I. The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival Journal of Experimental Medicine. 201: 603-614. PMID 15728238 DOI: 10.1084/jem.20041924  0.88
2005 Kanellopoulou C, Muljo SA, Kung AL, Ganesan S, Drapkin R, Jenuwein T, Livingston DM, Rajewsky K. Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes & Development. 19: 489-501. PMID 15713842 DOI: 10.1101/gad.1248505  0.88
2005 Koralov SB, Novobrantseva TI, Hochedlinger K, Jaenisch R, Rajewsky K. Direct in vivo VH to JH rearrangement violating the 12/23 rule. The Journal of Experimental Medicine. 201: 341-8. PMID 15699070 DOI: 10.1084/jem.20041577  0.88
2004 Roers A, Siewe L, Strittmatter E, Deckert M, Schlüter D, Stenzel W, Gruber AD, Krieg T, Rajewsky K, Müller W. T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation. The Journal of Experimental Medicine. 200: 1289-97. PMID 15534372 DOI: 10.1084/jem.20041789  0.88
2004 Mostoslavsky R, Alt FW, Rajewsky K. The lingering enigma of the allelic exclusion mechanism. Cell. 118: 539-44. PMID 15339659 DOI: 10.1016/j.cell.2004.08.023  0.88
2004 Sasaki Y, Casola S, Kutok JL, Rajewsky K, Schmidt-Supprian M. TNF family member B cell-activating factor (BAFF) receptor-dependent and -independent roles for BAFF in B cell physiology Journal of Immunology. 173: 2245-2252. PMID 15294936  0.88
2004 Schmidt-Supprian M, Tian J, Ji H, Terhorst C, Bhan AK, Grant EP, Pasparakis M, Casola S, Coyle AJ, Rajewsky K. IκB kinase 2 deficiency in T cells leads to defects in priming, B cell help, germinal center reactions, and homeostatic expansion Journal of Immunology. 173: 1612-1619. PMID 15265889  0.88
2004 Bender TP, Kremer CS, Kraus M, Buch T, Rajewsky K. Critical functions for c-Myb at three checkpoints during thymocyte development Nature Immunology. 5: 721-729. PMID 15195090 DOI: 10.1038/ni1085  0.88
2004 Kraus M, Alimzhanov MB, Rajewsky N, Rajewsky K. Survival of resting mature B lymphocytes depends on BCR signaling via the Igα/β heterodimer Cell. 117: 787-800. PMID 15186779 DOI: 10.1016/j.cell.2004.05.014  0.88
2004 Hao Z, Hampel B, Yagita H, Rajewsky K. T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis Journal of Experimental Medicine. 199: 1355-1365. PMID 15148335 DOI: 10.1084/jem.20032196  0.88
2004 Schmidt-Supprian M, Tian J, Grant EP, Pasparakis M, Maehr R, Ovaa H, Ploegh HL, Coyle AJ, Rajewsky K. Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-κB activation Proceedings of the National Academy of Sciences of the United States of America. 101: 4566-4571. PMID 15070758 DOI: 10.1073/pnas.0400885101  0.88
2004 Reichlin A, Gazumyan A, Nagaoka H, Kirsch KH, Kraus M, Rajewsky K, Nussenzweig MC. A B cell receptor with two Igalpha cytoplasmic domains supports development of mature but anergic B cells. The Journal of Experimental Medicine. 199: 855-65. PMID 15024049 DOI: 10.1084/jem.20031140  0.88
2004 Skulina C, Schmidt S, Dornmair K, Babbe H, Roers A, Rajewsky K, Wekerle H, Hohlfeld R, Goebels N. Multiple sclerosis: brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood. Proceedings of the National Academy of Sciences of the United States of America. 101: 2428-33. PMID 14983026 DOI: 10.1073/pnas.0308689100  0.88
2004 Casola S, Otipoby KL, Alimzhanov M, Humme S, Uyttersprot N, Kutok JL, Carroll MC, Rajewsky K. B cell receptor signal strength determines B cell fate Nature Immunology. 5: 317-327. PMID 14758357 DOI: 10.1038/ni1036  0.88
2004 Röhl M, Pasparakis M, Baudler S, Baumgartl J, Gautam D, Huth M, De Lorenzi R, Krone W, Rajewsky K, Brüning JC. Conditional disruption of IκB kinase 2 fails to prevent obesity-induced insulin resistance Journal of Clinical Investigation. 113: 474-481. PMID 14755344 DOI: 10.1172/JCI200418712  0.88
2003 Oberdoerffer P, Otipoby KL, Maruyama M, Rajewsky K. Unidirectional Cre-mediated genetic inversion in mice using the mutant loxP pair lox66/lox71 Nucleic Acids Research. 31: e140. PMID 14602933  0.88
2003 Kanters E, Pasparakis M, Gijbels MJJ, Vergouwe MN, Partouns-Hendriks I, Fijneman RJA, Clausen BE, Förster I, Kockx MM, Rajewsky K, Kraal G, Hofker MH, De Winther MPJ. Inhibition of NF-κB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice Journal of Clinical Investigation. 112: 1176-1185. PMID 14561702 DOI: 10.1172/JCI200318580  0.88
2003 Apostolou I, Hao Z, Rajewsky K, Von Boehmer H. Effective destruction of Fas-deficient insulin-producing β cells in type 1 diabetes Journal of Experimental Medicine. 198: 1103-1106. PMID 14530378 DOI: 10.1084/jem.20030698  0.88
2003 Schmidt-Supprian M, Courtois G, Tian J, Coyle AJ, Israël A, Rajewsky K, Pasparakis M. Mature T cells depend on signaling through the IKK complex Immunity. 19: 377-389. PMID 14499113 DOI: 10.1016/S1074-7613(03)00237-1  0.88
2003 Schwering I, Bräuninger A, Distler V, Jesdinsky J, Diehl V, Hansmann ML, Rajewsky K, Küppers R. Profiling of Hodgkin's lymphoma cell line l1236 and germinal center B cells: Identification of Hodgkin's lymphoma-specific genes Molecular Medicine. 9: 85-95. PMID 12865944  0.88
2003 Ippolito GC, Pelkonen J, Nitschke L, Rajewsky K, Schroeder HW. Antibody repertoire in a mouse with a simplified D(H) locus: the D-limited mouse. Annals of the New York Academy of Sciences. 987: 262-5. PMID 12727649  0.88
2003 Oberdoerffer P, Novobrantseva TI, Rajewsky K. Expression of a targeted λ1 light chain gene is developmentally regulated and independent of Igκ rearrangements Journal of Experimental Medicine. 197: 1165-1172. PMID 12719477 DOI: 10.1084/jem.20030402  0.88
2003 Bräuninger A, Wacker HH, Rajewsky K, Küppers R, Hansmann ML. Typing the histogenetic origin of the tumor cells of lymphocyte-rich classical Hodgkin's lymphoma in relation to tumor cells of classical and lymphocyte-predominance Hodgkin's lymphoma Cancer Research. 63: 1644-1651. PMID 12670918  0.88
2003 Kurth J, Hansmann ML, Rajewsky K, Küppers R. Epstein-Barr virus-infected B cells expanding in germinal centers of infectious mononucleosis patients do not participate in the germinal center reaction Proceedings of the National Academy of Sciences of the United States of America. 100: 4730-4735. PMID 12665622 DOI: 10.1073/pnas.2627966100  0.88
2003 Iwakoshi NN, Lee AH, Vallabhajosyula P, Otipoby KL, Rajewsky K, Glimcher LH. Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-I Nature Immunology. 4: 321-329. PMID 12612580 DOI: 10.1038/ni907  0.88
2003 Seibler J, Zevnik B, Küter-Luks B, Andreas S, Kern H, Hennek T, Rode A, Heimann C, Faust N, Kauselmann G, Schoor M, Jaenisch R, Rajewsky K, Kühn R, Schwenk F. Rapid generation of inducible mouse mutants. Nucleic Acids Research. 31: e12. PMID 12582257  0.88
2003 Schwering I, Bräuninger A, Klein U, Jungnickel B, Tinguely M, Diehl V, Hansmann ML, Dalla-Favera R, Rajewsky K, Küppers R. Loss of the B-lineage-specific gene expression program in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma Blood. 101: 1505-1512. PMID 12393731 DOI: 10.1182/blood-2002-03-0839  0.88
2003 Rajewsky K, Radbruch A. The Cellular Basis of B Cell Memory Molecular Biology of B Cells. 247-259. DOI: 10.1016/B978-012053641-2/50017-4  0.88
2002 Schenten D, Gerlach VL, Guo C, Velasco-Miguel S, Hladik CL, White CL, Friedberg EC, Rajewsky K, Esposito G. DNA polymerase K deficiency does not affect somatic hypermutation in mice European Journal of Immunology. 32: 3152-3160. PMID 12555660 DOI: 10.1002/1521-4141(200211)32:11<3152::AID-IMMU3152>3.0.CO;2-2  0.88
2002 Kurth J, Perniok A, Schmitz R, Iking-Konert C, Chiorazzi N, Thompson KM, Winkler T, Rajewsky K, Küppers R. Lack of deleterious somatic mutations in the CD95 gene of plasmablasts from systemic lupus erythematosus patients and autoantibody-producing cell lines. European Journal of Immunology. 32: 3785-92. PMID 12516573 DOI: 10.1002/1521-4141(200212)32:12<3785::AID-IMMU3785>3.0.CO;2-E  0.88
2002 Schönig K, Schwenk F, Rajewsky K, Bujard H. Stringent doxycycline dependent control of CRE recombinase in vivo Nucleic Acids Research. 30: e134. PMID 12466566  0.88
2002 Kuprash DV, Alimzhanov MB, Tumanov AV, Grivennikov SI, Shakhov AN, Drutskaya LN, Marino MW, Turetskaya RL, Anderson AO, Rajewsky K, Pfeffer K, Nedospasov SA. Redundancy in tumor necrosis factor (TNF) and lymphotoxin (LT) signaling in vivo: mice with inactivation of the entire TNF/LT locus versus single-knockout mice. Molecular and Cellular Biology. 22: 8626-34. PMID 12446781 DOI: 10.1128/MCB.22.24.8626-8634.2002  0.88
2002 Hasan M, Polic B, Bralic M, Jonjic S, Rajewsky K. Incomplete block of B cell development and immunoglobulin production in mice carrying the μMT mutation on the BALB/c background European Journal of Immunology. 32: 3463-3471. PMID 12442328 DOI: 10.1002/1521-4141(200212)32:12<3463::AID-IMMU3463>3.0.CO;2-B  0.88
2002 Feldhahn N, Schwering I, Lee S, Wartenberg M, Klein F, Wang H, Zhou G, Wang SM, Rowley JD, Hescheler J, Krönke M, Rajewsky K, Küppers R, Müschen M. Silencing of B cell receptor signals in human naive B cells. The Journal of Experimental Medicine. 196: 1291-305. PMID 12438421 DOI: 10.1084/jem.20020881  0.88
2002 Pasparakis M, Schmidt-Supprian M, Rajewsky K. IκB kinase signaling is essential for maintenance of mature B cells Journal of Experimental Medicine. 196: 743-752. PMID 12235208 DOI: 10.1084/jem.20020907  0.88
2002 Küppers R, Schwering I, Bräuninger A, Rajewsky K, Hansmann ML. Biology of Hodgkin's lymphoma Annals of Oncology. 13: 11-18. PMID 12078890  0.88
2002 Pasparakis M, Courtois G, Hafner M, Schmidt-Supprian M, Nenci A, Toksoy A, Krampert M, Goebeler M, Gillitzer R, Israel A, Krieg T, Rajewsky K, Haase I. TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2 Nature. 417: 861-866. PMID 12075355 DOI: 10.1038/nature00820  0.88
2002 Buch T, Rieux-Laucat F, Förster I, Rajewsky K. Failure of HY-specific thymocytes to escape negative selection by receptor editing Immunity. 16: 707-718. PMID 12049722 DOI: 10.1016/S1074-7613(02)00312-6  0.88
2002 Rajewsky K. Obituary: César Milstein (1927-2002) Nature. 416: 806. PMID 11976669  0.88
2002 Müschen M, Rajewsky K, Krönke M, Küppers R. The origin of CD95-gene mutations in B-cell lymphoma. Trends in Immunology. 23: 75-80. PMID 11929130 DOI: 10.1016/S1471-4906(01)02115-9  0.88
2002 Peitz M, Pfannkuche K, Rajewsky K, Edenhofer F. Ability of the hydrophobic FGF and basic TAT peptides to promote cellular uptake of recombinant Cre recombinase: A tool for efficient genetic engineering of mammalian genomes Proceedings of the National Academy of Sciences of the United States of America. 99: 4489-4494. PMID 11904364 DOI: 10.1073/pnas.032068699  0.88
2001 Goossens T, Bräuninger A, Klein U, Küppers R, Rajewsky K. Receptor revision plays no major role in shaping the receptor repertoire of human memory B cells after the onset of somatic hypermutation European Journal of Immunology. 31: 3638-3648. PMID 11745384 DOI: 10.1002/1521-4141(200112)31:12<3638::AID-IMMU3638>3.0.CO;2-G  0.88
2001 Bräuninger A, Goossens T, Rajewsky K, Küppers R. Regulation of immunoglobulin light chain gene rearrangements during early B cell development in the human European Journal of Immunology. 31: 3631-3637. PMID 11745383 DOI: 10.1002/1521-4141(200112)31:12<3631::AID-IMMU3631>3.0.CO;2-L  0.88
2001 Hao Z, Rajewsky K. Homeostasis of peripheral B cells in the absence of B cell influx from the bone marrow Journal of Experimental Medicine. 194: 1151-1163. PMID 11602643 DOI: 10.1084/jem.194.8.1151  0.88
2001 Bräuninger A, Spieker T, Willenbrock K, Gaulard P, Wacker HH, Rajewsky K, Hansmann ML, Küppers R. Survival and clonal expansion of mutating "forbidden" (immunoglobulin receptor-deficient) Epstein-Barr virus-infected B cells in angioimmunoblastic T cell lymphoma Journal of Experimental Medicine. 194: 927-940. PMID 11581315 DOI: 10.1084/jem.194.7.927  0.88
2001 Kraus M, Pao LI, Reichlin A, Hu Y, Canono B, Cambier JC, Nussenzweig MC, Rajewsky K. Interference with immunoglobulin (Ig)α immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation modulates or blocks B cell development, depending on the availability of an Igβ cytoplasmic tail Journal of Experimental Medicine. 194: 455-469. PMID 11514602 DOI: 10.1084/jem.194.4.455  0.88
2001 Aranda M, Kanellopoulou C, Christ N, Peitz M, Rajewsky K, Dröge P. Altered directionality in the Cre-loxP site-specific recombination pathway Journal of Molecular Biology. 311: 453-459. PMID 11492999 DOI: 10.1006/jmbi.2001.4888  0.88
2001 Küppers R, Sousa AB, Baur AS, Strickler JG, Rajewsky K, Hansmann ML. Common germinal-center B-cell origin of the malignant cells in two composite lymphomas, involving classical hodgkin's disease and either follicular lymphoma or B-CLL Molecular Medicine. 7: 285-292. PMID 11474574  0.88
2001 Polic B, Kunkel D, Scheffold A, Rajewsky K. How alpha beta T cells deal with induced TCR alpha ablation. Proceedings of the National Academy of Sciences of the United States of America. 98: 8744-9. PMID 11447257 DOI: 10.1073/pnas.141218898  0.88
2001 Wunderlich FT, Wildner H, Rajewsky K, Edenhofer F. New variants of inducible Cre recombinase: a novel mutant of Cre-PR fusion protein exhibits enhanced sensitivity and an expanded range of inducibility Nucleic Acids Research. 29: E47. PMID 11353092  0.88
2001 Müschen M, Küppers R, Spieker T, Bräuninger A, Rajewsky K, Hansmann ML. Molecular single-cell analysis of Hodgkin- and Reed-Sternberg cells harboring unmutated immunoglobulin variable region genes Laboratory Investigation. 81: 289-295. PMID 11310822  0.88
2001 Casellas R, Shih TA, Kleinewietfeld M, Rakonjac J, Nemazee D, Rajewsky K, Nussenzweig MC. Contribution of receptor editing to the antibody repertoire. Science (New York, N.Y.). 291: 1541-4. PMID 11222858 DOI: 10.1126/science.291.5508.1541  0.88
2001 Jacobs H, Rajewsky K, Fukita Y, Bross L. Indirect and direct evidence for DNA double-strand breaks in hypermutating immunoglobulin genes Philosophical Transactions of the Royal Society B: Biological Sciences. 355: 119-125. PMID 11205324  0.88
2001 de Alboran IM, O'Hagan RC, Gärtner F, Malynn B, Davidson L, Rickert R, Rajewsky K, DePinho RA, Alt FW. Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. Immunity. 14: 45-55. PMID 11163229 DOI: 10.1016/S1074-7613(01)00088-7  0.88
2001 Küppers R, Bräuninger A, Müschen M, Distler V, Hansmann ML, Rajewsky K. Evidence that Hodgkin and Reed-Sternberg cells in Hodgkin disease do not represent cell fusions Blood. 97: 818-821. PMID 11157505 DOI: 10.1182/blood.V97.3.818  0.88
2001 Bräuninger A, Yang W, Wacker HH, Rajewsky K, Küppers R, Hansmann ML. B-cell development in progressively transformed germinal centers: Similarities and differences compared with classical germinal centers and lymphocyte-predominant Hodgkin disease Blood. 97: 714-719. PMID 11157489 DOI: 10.1182/blood.V97.3.714  0.88
2001 Reichlin A, Hu Y, Meffre E, Nagaoka H, Gong S, Kraus M, Rajewsky K, Nussenzweig MC. B cell development is arrested at the immature B cell stage in mice carrying a mutation in the cytoplasmic domain of immunoglobulin β Journal of Experimental Medicine. 193: 13-23. PMID 11136817 DOI: 10.1084/jem.193.1.13  0.88
2000 Müschen M, Re D, Jungnickel B, Diehl V, Rajewsky K, Küppers R. Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reaction Journal of Experimental Medicine. 192: 1833-1839. PMID 11120779 DOI: 10.1084/jem.192.12.1833  0.88
2000 Bross L, Fukita Y, McBlane F, Démollière C, Rajewsky K, Jacobs H. DNA double-strand breaks in immunoglobulin genes undergoing somatic hypermutation Immunity. 13: 589-597. PMID 11114372  0.88
2000 Kurth J, Spieker T, Wustrow J, Strickler JG, Hansmann ML, Rajewsky K, Küppers R. EBV-infected B cells in infectious mononucleosis: Viral strategies for spreading in the B cell compartment and establishing latency Immunity. 13: 485-495. PMID 11070167  0.88
2000 Geiger KD, Klein U, Bräuninger A, Berger S, Leder K, Rajewsky K, Hansmann ML, Küppers R. CD5-positive B cells in healthy elderly humans are a polyclonal B cell population European Journal of Immunology. 30: 2918-2923. PMID 11069074 DOI: 10.1002/1521-4141(200010)30:10<2918::AID-IMMU2918>3.0.CO;2-C  0.88
2000 Muschen M, Re D, Brauninger A, Wolf J, Hansmann ML, Diehl V, Kuppers R, Rajewsky K. Somatic mutations of the CD95 gene in Hodgkin and Reed-Sternberg cells Cancer Research. 60: 5640-5643. PMID 11059754  0.88
2000 Esposito G, Godin I, Klein U, Yaspo ML, Cumano A, Rajewsky K. Disruption of the Rev3l-encoded catalytic subunit of polymerase ζ in mice results in early embryonic lethality Current Biology. 10: 1221-1224. PMID 11050393 DOI: 10.1016/S0960-9822(00)00726-0  0.88
2000 Spieker T, Kurth J, Kuppers R, Rajewsky K, Brauninger A, Hansmann ML. Molecular single-cell analysis of the clonal relaionship of small Epstein-Barr virus-infected cells and Epstein-Barr virus-harboring Hodgkin and Reed/Sternberg cells in Hodgkin disease Blood. 96: 3133-3138. PMID 11049994  0.88
2000 Maruyama M, Lam KP, Rajewsky K. Memory B-cell persistence is independent of persisting immunizing antigen Nature. 407: 636-642. PMID 11034213 DOI: 10.1038/35036600  0.88
2000 Babbe H, Roers A, Waisman A, Lassmann H, Goebels N, Hohlfeld R, Friese M, Schröder R, Deckert M, Schmidt S, Ravid R, Rajewsky K. Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction. The Journal of Experimental Medicine. 192: 393-404. PMID 10934227 DOI: 10.1084/jem.192.3.393  0.88
2000 Schmidt-Supprian M, Bloch W, Courtois G, Addicks K, Israël A, Rajewsky K, Pasparakis M. NEMO/IKKγ-deficient mice model incontinentia pigmenti Molecular Cell. 5: 981-992. PMID 10911992  0.88
2000 Vosshenrich CAJ, Sharara LI, Guy-Grand D, Rajewsky K, Müller W, Di Santo JP. Common cytokine receptor γ chain (γ(c))-deficient B cells persist in T cell-deficient γ(c)- mice and respond to a T-independent antigen European Journal of Immunology. 30: 1614-1622. PMID 10898497 DOI: 10.1002/1521-4141(200006)30:6<1614::AID-IMMU1614>3.0.CO;2-I  0.88
2000 Ogata H, Su IH, Miyake K, Nagai Y, Akashi S, Mecklenbräuker I, Rajewsky K, Kimoto M, Tarakhovsky A. The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells Journal of Experimental Medicine. 192: 23-29. PMID 10880523 DOI: 10.1084/jem.192.1.23  0.88
2000 Willenbrock K, Roers A, Blohbaum B, Rajewsky K, Hansmann ML. CD8+ T cells in Hodgkin's disease tumor tissue are a polyclonal population with limited clonal expansion but little evidence of selection by antigen American Journal of Pathology. 157: 171-175. PMID 10880387  0.88
2000 Braun U, Rajewsky K, Pelanda R. Different sensitivity to receptor editing of B cells from mice hemizygous or homozygous for targeted Ig transgenes Proceedings of the National Academy of Sciences of the United States of America. 97: 7429-7434. PMID 10829061 DOI: 10.1073/pnas.050578497  0.88
2000 Roers A, Hansmann ML, Rajewsky K, Küppers R. Single-cell PCR analysis of T helper cells in human lymph node germinal centers American Journal of Pathology. 156: 1067-1071. PMID 10702422  0.88
2000 Esposito G, Texido G, Betz UAK, Gu H, Müller W, Klein U, Rajewsky K. Mice reconstituted with DNA polymerase β-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally Proceedings of the National Academy of Sciences of the United States of America. 97: 1166-1171. PMID 10655502 DOI: 10.1073/pnas.97.3.1166  0.88
2000 Texido G, Su IH, Mecklenbräuker I, Saijo K, Malek SN, Desiderio S, Rajewsky K, Tarakhovsky A. The B-cell-specific Src-family kinase Blk is dispensable for B-cell development and activation. Molecular and Cellular Biology. 20: 1227-33. PMID 10648608 DOI: 10.1128/MCB.20.4.1227-1233.2000  0.88
2000 Kanzler H, Küppers R, Helmes S, Wacker HH, Chott A, Hansmann ML, Rajewsky K. Hodgkin and Reed-Sternberg-like cells in B-cell chronic lymphocytic leukemia represent the outgrowth of single germinal-center B-cell-derived clones: Potential precursors of Hodgkin and Reed-Sternberg cells in Hodgkin's disease Blood. 95: 1023-1031. PMID 10648418  0.88
2000 Jungnickel B, Staratschek-Jox A, Bräuninger A, Spieker T, Wolf J, Diehl V, Hansmann ML, Rajewsky K, Küppers R. Clonal deleterious mutations in the iκbα gene in the malignant cells in Hodgkin's lymphoma Journal of Experimental Medicine. 191: 395-401. PMID 10637284 DOI: 10.1084/jem.191.2.395  0.88
2000 Müschen M, Rajewsky K, Bräuninger A, Baur AS, Oudejans JJ, Roers A, Hansmann ML, Küppers R. Rare occurrence of classical Hodgkin's disease as a T cell lymphoma Journal of Experimental Medicine. 191: 387-394. PMID 10637283 DOI: 10.1084/jem.191.2.387  0.88
2000 Von Boehmer H, Rajewsky K. Lymphocyte development. Commitment, selection and switching Current Opinion in Immunology. 12: 141-143. DOI: 10.1016/S0952-7915(99)00063-1  0.88
1999 Kraus M, Saijo K, Torres RM, Rajewsky K. Ig-alpha cytoplasmic truncation renders immature B cells more sensitive to antigen contact. Immunity. 11: 537-45. PMID 10591179  0.88
1999 Küppers R, Klein U, Hansmann ML, Rajewsky K. Cellular origin of human B-cell lymphomas New England Journal of Medicine. 341: 1520-1529. PMID 10559454 DOI: 10.1056/NEJM199911113412007  0.88
1999 Montesinos-Rongen M, Roers A, Küppers R, Rajewsky K, Hansmann ML. Mutation of the p53 gene is not a typical feature of Hodgkin and Reed- Sternberg cells in Hodgkin's disease Blood. 94: 1755-1760. PMID 10477701  0.88
1999 Lam KP, Rajewsky K. B cell antigen receptor specificity and surface density together determine B-1 versus B-2 cell development Journal of Experimental Medicine. 190: 471-477. PMID 10449518 DOI: 10.1084/jem.190.4.471  0.88
1994 Wagner SD, Williams GT, Larson T, Neuberger MS, Kitamura D, Rajewsky K, Xian J, Brüggemann M. Antibodies generated from human immunoglobulin miniloci in transgenic mice. Nucleic Acids Research. 22: 1389-93. PMID 8190629 DOI: 10.1093/nar/22.8.1389  0.88
1981 Neuberger MS, Rajewsky K. Activation of mouse complement by monoclonal mouse antibodies. European Journal of Immunology. 11: 1012-6. PMID 7327198 DOI: 10.1002/eji.1830111212  0.96
1981 Neuberger MS, Rajewsky K. Switch from hapten-specific immunoglobulin M to immunoglobulin D secretion in a hybrid mouse cell line. Proceedings of the National Academy of Sciences of the United States of America. 78: 1138-42. PMID 6940132  0.96
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