Roberto Pellicciari - Publications

Affiliations: 
Università di Perugia 

210 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Passeri D, Carotti A, Pittol JMR, Ciaccioli G, Pellicciari R, van Mil SWC, Gioiello A. Dissecting the allosteric FXR modulation: a chemical biology approach using guggulsterone as a chemical tool. Medchemcomm. 10: 1412-1419. PMID 31673308 DOI: 10.1039/c9md00264b  0.84
2019 Cerra B, Carotti A, Passeri D, Sardella R, Moroni G, Di Michele A, Macchiarulo A, Pellicciari R, Gioiello A. Exploiting Chemical Toolboxes for the Expedited Generation of Tetracyclic Quinolines as a Novel Class of PXR Agonists. Acs Medicinal Chemistry Letters. 10: 677-681. PMID 30996817 DOI: 10.1021/acsmedchemlett.8b00459  0.96
2019 Roberti M, Schipani F, Bagnolini G, Milano D, Giacomini E, Falchi F, Balboni A, Manerba M, Farabegoli F, De Franco F, Robertson J, Minucci S, Pallavicini I, Di Stefano G, Girotto S, ... Pellicciari R, et al. Rad51/BRCA2 disruptors inhibit homologous recombination and synergize with olaparib in pancreatic cancer cells. European Journal of Medicinal Chemistry. 165: 80-92. PMID 30660828 DOI: 10.1016/j.ejmech.2019.01.008  0.44
2018 Katsyuba E, Mottis A, Zietak M, De Franco F, van der Velpen V, Gariani K, Ryu D, Cialabrini L, Matilainen O, Liscio P, Giacchè N, Stokar-Regenscheit N, Legouis D, de Seigneux S, Ivanisevic J, ... ... Pellicciari R, et al. De novo NAD synthesis enhances mitochondrial function and improves health. Nature. PMID 30356218 DOI: 10.1038/s41586-018-0645-6  0.64
2018 Massafra V, Pellicciari R, Gioiello A, van Mil SWC. Progress and challenges of selective Farnesoid X receptor modulation. Pharmacology & Therapeutics. PMID 29933033 DOI: 10.1016/j.pharmthera.2018.06.009  0.84
2018 Pellicciari R, Liscio P, Giacchè N, De Franco F, Carotti A, Robertson J, Cialabrini L, Katsyuba E, Raffaelli N, Auwerx J. α-Amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) Inhibitors as Novel Modulators of de novo Nicotinamide Adenine Dinucleotide (NAD+) Biosynthesis. Journal of Medicinal Chemistry. PMID 29345930 DOI: 10.1021/acs.jmedchem.7b01254  0.76
2017 Mostarda S, Passeri D, Carotti A, Cerra B, Colliva C, Benicchi T, Macchiarulo A, Pellicciari R, Gioiello A. Synthesis, physicochemical properties, and biological activity of bile acids 3-glucuronides: Novel insights into bile acid signalling and detoxification. European Journal of Medicinal Chemistry. 144: 349-358. PMID 29275233 DOI: 10.1016/j.ejmech.2017.12.034  0.96
2017 Falchi F, Giacomini E, Masini T, Boutard N, Di Ianni L, Manerba M, Farabegoli F, Rossini L, Robertson J, Minucci S, Pallavicini I, Di Stefano G, Pellicciari R, Roberti M, Cavalli A. Synthetic lethality triggered by combining Olaparib with BRCA2-Rad51 disruptors. Acs Chemical Biology. PMID 28841282 DOI: 10.1021/acschembio.7b00707  0.44
2017 Moniot S, Forgione M, Lucidi A, Hailu GS, Nebbioso A, Carafa V, Baratta F, Altucci L, Giacchè N, Passeri D, Pellicciari R, Mai A, Steegborn C, Rotili D. Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2: Structure-Activity Relationship, X-Ray Crystal Structure and Anticancer Activity. Journal of Medicinal Chemistry. PMID 28240897 DOI: 10.1021/acs.jmedchem.6b01609  0.56
2016 Pellicciari R, Passeri D, De Franco F, Mostarda S, Filipponi P, Colliva C, Gadaleta R, Franco P, Carotti A, Macchiarulo A, Roda A, Moschetta A, Gioiello A. Discovery of 3α,7α,11β-Trihydroxy-6α-ethyl-5β-cholan-24-oic Acid (TC-100), a Novel Bile Acid as Potent and Highly Selective FXR Agonist for Enterohepatic Disorders. Journal of Medicinal Chemistry. PMID 27652492 DOI: 10.1021/acs.jmedchem.6b01126  0.96
2015 Niccoli Asabella A, Gigante AF, Ferrari C, Di Palo A, Rubini D, Mossa EP, Dagostino S, Pellicciari R, Defazio G, Rubini G. Role of dopaminergic neurotransmission in pathophysiology of action tremor in Parkinson's disease. Hellenic Journal of Nuclear Medicine. 18: 11-6. PMID 26665206  0.44
2015 Passeri D, Camaioni E, Liscio P, Sabbatini P, Ferri M, Carotti A, Giacchè N, Pellicciari R, Gioiello A, Macchiarulo A. Concepts and Molecular Aspects in the Polypharmacology of PARP-1 Inhibitors. Chemmedchem. PMID 26424664 DOI: 10.1002/cmdc.201500391  0.96
2015 Bijsmans IT, Guercini C, Ramos Pittol JM, Omta W, Milona A, Lelieveld D, Egan DA, Pellicciari R, Gioiello A, van Mil SW. The glucocorticoid mometasone furoate is a novel FXR ligand that decreases inflammatory but not metabolic gene expression. Scientific Reports. 5: 14086. PMID 26369990 DOI: 10.1038/srep14086  0.96
2015 Pellegrino M, Mancini F, Lucà R, Coletti A, Giacchè N, Manni I, Arisi I, Florenzano F, Teveroni E, Buttarelli M, Fici L, Brandi R, Bruno T, Fanciulli M, D'Onofrio M, ... ... Pellicciari R, et al. Targeting the MDM2/MDM4 Interaction Interface as a Promising Approach for p53 Reactivation Therapy. Cancer Research. 75: 4560-72. PMID 26359458 DOI: 10.1158/0008-5472.CAN-15-0439  0.96
2015 Zhang W, Jha P, Wolfe B, Gioiello A, Pellicciari R, Wang J, Heubi J, Setchell KD. Tandem Mass Spectrometric Determination of Atypical 3β-Hydroxy-Δ5-Bile Acids in Patients with 3β-Hydroxy-Δ5-C27-Steroid Oxidoreductase Deficiency: Application to Diagnosis and Monitoring of Bile Acid Therapeutic Response. Clinical Chemistry. 61: 955-63. PMID 25931455 DOI: 10.1373/clinchem.2015.238238  0.96
2014 Carotti A, Marinozzi M, Custodi C, Cerra B, Pellicciari R, Gioiello A, Macchiarulo A. Beyond bile acids: targeting Farnesoid X Receptor (FXR) with natural and synthetic ligands. Current Topics in Medicinal Chemistry. 14: 2129-42. PMID 25388537  0.96
2014 Gioiello A, Cerra B, Mostarda S, Guercini C, Pellicciari R, Macchiarulo A. Bile acid derivatives as ligands of the farnesoid x receptor: molecular determinants for bile acid binding and receptor modulation. Current Topics in Medicinal Chemistry. 14: 2159-74. PMID 25388535  0.96
2014 Perino A, Pols TW, Nomura M, Stein S, Pellicciari R, Schoonjans K. TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation. The Journal of Clinical Investigation. 124: 5424-36. PMID 25365223 DOI: 10.1172/JCI76289  0.96
2014 Mostarda S, Filipponi P, Sardella R, Venturoni F, Natalini B, Pellicciari R, Gioiello A. Glucuronidation of bile acids under flow conditions: design of experiments and Koenigs-Knorr reaction optimization. Organic & Biomolecular Chemistry. 12: 9592-600. PMID 25338931 DOI: 10.1039/c4ob01911c  0.96
2014 Liscio P, Carotti A, Asciutti S, Ferri M, Pires MM, Valloscuro S, Ziff J, Clark NR, Macchiarulo A, Aaronson SA, Pellicciari R, Camaioni E. Scaffold hopping approach on the route to selective tankyrase inhibitors. European Journal of Medicinal Chemistry. 87: 611-23. PMID 25299683 DOI: 10.1016/j.ejmech.2014.10.007  0.96
2014 Marchand JR, Carotti A, Passeri D, Filipponi P, Liscio P, Camaioni E, Pellicciari R, Gioiello A, Macchiarulo A. Investigating the allosteric reverse signalling of PARP inhibitors with microsecond molecular dynamic simulations and fluorescence anisotropy. Biochimica Et Biophysica Acta. 1844: 1765-72. PMID 25062913 DOI: 10.1016/j.bbapap.2014.07.012  0.96
2014 Gioiello A, Cerra B, Zhang W, Vallerini GP, Costantino G, De Franco F, Passeri D, Pellicciari R, Setchell KD. Synthesis of atypical bile acids for use as investigative tools for the genetic defect of 3β-hydroxy-Δ(5)-C27-steroid oxidoreductase deficiency. The Journal of Steroid Biochemistry and Molecular Biology. 144: 348-60. PMID 24954360 DOI: 10.1016/j.jsbmb.2014.06.008  0.96
2014 Roda A, Pellicciari R, Gioiello A, Neri F, Camborata C, Passeri D, De Franco F, Spinozzi S, Colliva C, Adorini L, Montagnani M, Aldini R. Semisynthetic bile acid FXR and TGR5 agonists: physicochemical properties, pharmacokinetics, and metabolism in the rat. The Journal of Pharmacology and Experimental Therapeutics. 350: 56-68. PMID 24784847 DOI: 10.1124/jpet.114.214650  0.96
2014 Liscio P, Carotti A, Asciutti S, Karlberg T, Bellocchi D, Llacuna L, Macchiarulo A, Aaronson SA, Schüler H, Pellicciari R, Camaioni E. Design, synthesis, crystallographic studies, and preliminary biological appraisal of new substituted triazolo[4,3-b]pyridazin-8-amine derivatives as tankyrase inhibitors. Journal of Medicinal Chemistry. 57: 2807-12. PMID 24527792 DOI: 10.1021/jm401356t  0.96
2014 Lucarini L, Pini A, Gerace E, Pellicciari R, Masini E, Moroni F. Poly(ADP-ribose) polymerase inhibition with HYDAMTIQ reduces allergen-induced asthma-like reaction, bronchial hyper-reactivity and airway remodelling. Journal of Cellular and Molecular Medicine. 18: 468-79. PMID 24444146 DOI: 10.1111/jcmm.12197  0.96
2014 Gioiello A, Venturoni F, Tamimi S, Custodi C, Pellicciari R, MacChiarulo A. Conformational properties of cholic acid, a lead compound at the crossroads of bile acid inspired drug discovery Medchemcomm. 5: 750-757. DOI: 10.1039/c4md00024b  0.96
2014 Filipponi P, Ostacolo C, Novellino E, Pellicciari R, Gioiello A. Continuous flow synthesis of thieno[2,3-c ]isoquinolin-5(4 H)-one scaffold: A valuable source of PARP-1 inhibitors Organic Process Research and Development. 18: 1345-1353. DOI: 10.1021/op500074h  0.96
2013 Macchiarulo A, Gioiello A, Thomas C, Pols TW, Nuti R, Ferrari C, Giacchè N, De Franco F, Pruzanski M, Auwerx J, Schoonjans K, Pellicciari R. Probing the Binding Site of Bile Acids in TGR5. Acs Medicinal Chemistry Letters. 4: 1158-62. PMID 24900622 DOI: 10.1021/ml400247k  0.96
2013 Liscio P, Camaioni E, Carotti A, Pellicciari R, Macchiarulo A. From polypharmacology to target specificity: the case of PARP inhibitors. Current Topics in Medicinal Chemistry. 13: 2939-54. PMID 24171773  0.96
2013 Antolin AA, Carotti A, Nuti R, Hakkaya A, Camaioni E, Mestres J, Pellicciari R, Macchiarulo A. Exploring the effect of PARP-1 flexibility in docking studies. Journal of Molecular Graphics & Modelling. 45: 192-201. PMID 24056306 DOI: 10.1016/j.jmgm.2013.08.006  0.96
2013 Sabbatini P, Filipponi P, Sardella R, Natalini B, Nuti R, Macchiarulo A, Pellicciari R, Gioiello A. Synthesis and quantitative structure-property relationships of side chain-modified hyodeoxycholic acid derivatives. Molecules (Basel, Switzerland). 18: 10497-513. PMID 23999724 DOI: 10.3390/molecules180910497  0.96
2013 Marinozzi M, Carotti A, Sardella R, Buonerba F, Ianni F, Natalini B, Passeri D, Rizzo G, Pellicciari R. Asymmetric synthesis of the four diastereoisomers of a novel non-steroidal farnesoid X receptor (FXR) agonist: role of the chirality on the biological activity. Bioorganic & Medicinal Chemistry. 21: 3780-9. PMID 23684233 DOI: 10.1016/j.bmc.2013.04.038  0.96
2013 Gioiello A, Rosatelli E, Teofrasti M, Filipponi P, Pellicciari R. Building a sulfonamide library by eco-friendly flow synthesis. Acs Combinatorial Science. 15: 235-9. PMID 23514257 DOI: 10.1021/co400012m  0.96
2013 Kelly OB, Mroz MS, Ward JB, Colliva C, Scharl M, Pellicciari R, Gilmer JF, Fallon PG, Hofmann AF, Roda A, Murray FE, Keely SJ. Ursodeoxycholic acid attenuates colonic epithelial secretory function. The Journal of Physiology. 591: 2307-18. PMID 23507881 DOI: 10.1113/jphysiol.2013.252544  0.96
2012 Pellicciari R, Gioiello A, Sabbatini P, Venturoni F, Nuti R, Colliva C, Rizzo G, Adorini L, Pruzanski M, Roda A, Macchiarulo A. Avicholic Acid: A Lead Compound from Birds on the Route to Potent TGR5 Modulators. Acs Medicinal Chemistry Letters. 3: 273-7. PMID 24900463 DOI: 10.1021/ml200256d  0.96
2012 Gioiello A, Rosatelli E, Nuti R, Macchiarulo A, Pellicciari R. Patented TGR5 modulators: a review (2006 - present). Expert Opinion On Therapeutic Patents. 22: 1399-414. PMID 23039746 DOI: 10.1517/13543776.2012.733000  0.96
2012 Marinozzi M, Carotti A, Sansone E, Macchiarulo A, Rosatelli E, Sardella R, Natalini B, Rizzo G, Adorini L, Passeri D, De Franco F, Pruzanski M, Pellicciari R. Pyrazole[3,4-e][1,4]thiazepin-7-one derivatives as a novel class of Farnesoid X Receptor (FXR) agonists. Bioorganic & Medicinal Chemistry. 20: 3429-45. PMID 22564381 DOI: 10.1016/j.bmc.2012.04.021  0.96
2012 Venturoni F, Gioiello A, Sardella R, Natalini B, Pellicciari R. Continuous flow synthesis and scale-up of glycine- and taurine-conjugated bile salts. Organic & Biomolecular Chemistry. 10: 4109-15. PMID 22517166 DOI: 10.1039/c2ob25528f  0.96
2012 Wahlberg E, Karlberg T, Kouznetsova E, Markova N, Macchiarulo A, Thorsell AG, Pol E, Frostell Ã…, Ekblad T, Öncü D, Kull B, Robertson GM, Pellicciari R, Schüler H, Weigelt J. Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors. Nature Biotechnology. 30: 283-8. PMID 22343925 DOI: 10.1038/nbt.2121  0.96
2012 Gioiello A, Sardella R, Rosatelli E, Sadeghpour BM, Natalini B, Pellicciari R. Novel stereoselective synthesis and chromatographic evaluation of E-guggulsterone. Steroids. 77: 250-4. PMID 22155267 DOI: 10.1016/j.steroids.2011.11.012  0.96
2012 Moroni F, Cozzi A, Chiarugi A, Formentini L, Camaioni E, Pellegrini-Giampietro DE, Chen Y, Liang S, Zaleska MM, Gonzales C, Wood A, Pellicciari R. Long-lasting neuroprotection and neurological improvement in stroke models with new, potent and brain permeable inhibitors of poly(ADP-ribose) polymerase. British Journal of Pharmacology. 165: 1487-500. PMID 21913897 DOI: 10.1111/j.1476-5381.2011.01666.x  0.96
2011 Natalini B, Sardella R, Macchiarulo A, Marinozzi M, Camaioni E, Pellicciari R. Mechanistic Aspects and Applications of Chiral Ligand-Exchange Chromatography. Advances in Chromatography. 49: 71-134. PMID 26434236  0.96
2011 Pols TW, Nomura M, Harach T, Lo Sasso G, Oosterveer MH, Thomas C, Rizzo G, Gioiello A, Adorini L, Pellicciari R, Auwerx J, Schoonjans K. TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading. Cell Metabolism. 14: 747-57. PMID 22152303 DOI: 10.1016/j.cmet.2011.11.006  0.96
2011 Gioiello A, Venturoni F, Marinozzi M, Natalini B, Pellicciari R. Exploring the synthetic versatility of the Lewis acid induced decomposition reaction of α-diazo-β-hydroxy esters. The case of ethyl diazo(3-hydroxy-2-oxo-2,3-dihydro-1H-indol-3-yl)acetate. The Journal of Organic Chemistry. 76: 7431-7. PMID 21800851 DOI: 10.1021/jo201205u  0.96
2011 Pocivavsek A, Wu HQ, Potter MC, Elmer GI, Pellicciari R, Schwarcz R. Fluctuations in endogenous kynurenic acid control hippocampal glutamate and memory. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 2357-67. PMID 21796108 DOI: 10.1038/npp.2011.127  0.96
2011 Natalini B, Sardella R, Gioiello A, Rosatelli E, Ianni F, Camaioni E, Pellicciari R. Fast chromatographic determination of the bile salt critical micellar concentration. Analytical and Bioanalytical Chemistry. 401: 267-74. PMID 21573726 DOI: 10.1007/s00216-011-5082-4  0.96
2011 Gioiello A, Macchiarulo A, Carotti A, Filipponi P, Costantino G, Rizzo G, Adorini L, Pellicciari R. Extending SAR of bile acids as FXR ligands: discovery of 23-N-(carbocinnamyloxy)-3α,7α-dihydroxy-6α-ethyl-24-nor-5β-cholan-23-amine. Bioorganic & Medicinal Chemistry. 19: 2650-8. PMID 21459580 DOI: 10.1016/j.bmc.2011.03.004  0.96
2011 Passera E, Campanini B, Rossi F, Casazza V, Rizzi M, Pellicciari R, Mozzarelli A. Human kynurenine aminotransferase II--reactivity with substrates and inhibitors. The Febs Journal. 278: 1882-900. PMID 21439022 DOI: 10.1111/j.1742-4658.2011.08106.x  0.96
2011 Macchiarulo A, Giacchè N, Mancini F, Puxeddu E, Moretti F, Pellicciari R. Alternative strategies for targeting mouse double minute 2 activity with small molecules: novel patents on the horizon? Expert Opinion On Therapeutic Patents. 21: 287-94. PMID 21342053 DOI: 10.1517/13543776.2011.546349  0.96
2011 Nielsen SD, Fulco M, Serpi M, Nielsen B, Hansen MB, Hansen KL, Thomsen C, Brodbeck R, Bräuner-Osborne H, Pellicciari R, Norrby PO, Greenwood JR, Clausen RP. A highly selective agonist for the metabotropic glutamate receptor mGluR2 Medchemcomm. 2: 1120-1124. DOI: 10.1039/c1md00186h  0.96
2011 Pellicciari R, Camaioni E, Gilbert AM, Macchiarulo A, Bikker JA, Shah F, Bard J, Costantino G, Gioiello A, Robertson GM, Sabbatini P, Venturoni F, Liscio P, Carotti A, Bellocchi D, et al. Discovery and characterization of novel potent PARP-1 inhibitors endowed with neuroprotective properties: From TIQ-A to HYDAMTIQ Medchemcomm. 2: 559-565. DOI: 10.1039/c1md00021g  0.96
2011 Pellicciari R. The Pellicciari group Medchemcomm. 2: MCW28-MCW33. DOI: 10.1039/c0md90027c  0.96
2011 Macchiarulo A, Giacchè N, Carotti A, Moretti F, Pellicciari R. Expanding the horizon of chemotherapeutic targets: From MDM2 to MDMX (MDM4) Medchemcomm. 2: 455-465. DOI: 10.1039/c0md00238k  0.96
2011 Gioiello A, Sabbatini P, Rosatelli E, MacChiarulo A, Pellicciari R. Divergent and stereoselective synthesis of dafachronic acids Tetrahedron. 67: 1924-1929. DOI: 10.1016/j.tet.2011.01.022  0.96
2011 Natalini B, Sardella R, Macchiarulo A, Marinozzi M, Camaioni E, Pellicciari R. Mechanistic aspects and applications of chiral ligand-exchange chromatography Advances in Chromatography. 49: 71-134.  0.96
2010 Natalini B, Giacchè N, Sardella R, Ianni F, Macchiarulo A, Pellicciari R. Computational studies for the elucidation of the enantiomer elution order of amino acids in chiral ligand-exchange chromatography. Journal of Chromatography. A. 1217: 7523-7. PMID 20977972 DOI: 10.1016/j.chroma.2010.10.001  0.96
2010 Cellanetti M, Gunda V, Wang L, Macchiarulo A, Pellicciari R. Insights into the binding mode and mechanism of action of some atypical retinoids as ligands of the small heterodimer partner (SHP). Journal of Computer-Aided Molecular Design. 24: 943-56. PMID 20882396 DOI: 10.1007/s10822-010-9386-9  0.96
2010 Dezi C, Carotti A, Magnani M, Baroni M, Padova A, Cruciani G, Macchiarulo A, Pellicciari R. Molecular interaction fields and 3D-QSAR studies of p53-MDM2 inhibitors suggest additional features of ligand-target interaction. Journal of Chemical Information and Modeling. 50: 1451-65. PMID 20726601 DOI: 10.1021/ci100113p  0.96
2010 Konradsson-Geuken A, Wu HQ, Gash CR, Alexander KS, Campbell A, Sozeri Y, Pellicciari R, Schwarcz R, Bruno JP. Cortical kynurenic acid bi-directionally modulates prefrontal glutamate levels as assessed by microdialysis and rapid electrochemistry. Neuroscience. 169: 1848-59. PMID 20600676 DOI: 10.1016/j.neuroscience.2010.05.052  0.96
2010 Zhou T, Zhang Y, Macchiarulo A, Yang Z, Cellanetti M, Coto E, Xu P, Pellicciari R, Wang L. Novel polymorphisms of nuclear receptor SHP associated with functional and structural changes. The Journal of Biological Chemistry. 285: 24871-81. PMID 20516075 DOI: 10.1074/jbc.M110.133280  0.96
2010 Natalini B, Sardella R, Giacchè N, Palmiotto S, Camaioni E, Marinozzi M, Macchiarulo A, Pellicciari R. Chiral ligand-exchange separation and resolution of extremely rigid glutamate analogs: 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acids. Analytical and Bioanalytical Chemistry. 397: 1997-2011. PMID 20496034 DOI: 10.1007/s00216-010-3669-9  0.96
2010 Tentori L, Muzi A, Dorio AS, Scarsella M, Leonetti C, Shah GM, Xu W, Camaioni E, Gold B, Pellicciari R, Dantzer F, Zhang J, Graziani G. Pharmacological inhibition of poly(ADP-ribose) polymerase (PARP) activity in PARP-1 silenced tumour cells increases chemosensitivity to temozolomide and to a N3-adenine selective methylating agent. Current Cancer Drug Targets. 10: 368-83. PMID 20464779 DOI: 10.2174/156800910791208571  0.96
2010 Mancini F, Di Conza G, Monti O, Macchiarulo A, Pellicciari R, Pontecorvi A, Moretti F. Puzzling over MDM4-p53 network. The International Journal of Biochemistry & Cell Biology. 42: 1080-3. PMID 20417304 DOI: 10.1016/j.biocel.2010.04.010  0.96
2010 Wu HQ, Pereira EF, Bruno JP, Pellicciari R, Albuquerque EX, Schwarcz R. The astrocyte-derived alpha7 nicotinic receptor antagonist kynurenic acid controls extracellular glutamate levels in the prefrontal cortex. Journal of Molecular Neuroscience : Mn. 40: 204-10. PMID 19690987 DOI: 10.1007/s12031-009-9235-2  0.96
2010 Roberti M, Natalini B, Andrisano V, Seraglia R, Gioiello A, Pellicciari R. Thermal and catalytic reactions of ethyl diazopyruvate with [60]fullerene Tetrahedron. 66: 7329-7332. DOI: 10.1016/j.tet.2010.06.067  0.96
2009 Asciutti S, Castellani D, Nardi E, Morelli O, Clementi M, Chistolini F, Gentili G, Setchell KD, O'Connell N, Pellicciari R, Clerici C. A new amino acid derivative of ursodeoxycholate, (N-L-Glutamyl)-UDCA (UDCA-Glu), to selectively release UDCA in the colon. Anticancer Research. 29: 4971-9. PMID 20044604  0.96
2009 Pellicciari R, Gioiello A, Macchiarulo A, Thomas C, Rosatelli E, Natalini B, Sardella R, Pruzanski M, Roda A, Pastorini E, Schoonjans K, Auwerx J. Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity. Journal of Medicinal Chemistry. 52: 7958-61. PMID 20014870 DOI: 10.1021/jm901390p  0.96
2009 Thomas C, Gioiello A, Noriega L, Strehle A, Oury J, Rizzo G, Macchiarulo A, Yamamoto H, Mataki C, Pruzanski M, Pellicciari R, Auwerx J, Schoonjans K. TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metabolism. 10: 167-77. PMID 19723493 DOI: 10.1016/j.cmet.2009.08.001  0.96
2009 Bellocchi D, Macchiarulo A, Carotti A, Pellicciari R. Quantum mechanics/molecular mechanics (QM/MM) modeling of the irreversible transamination of L-kynurenine to kynurenic acid: the round dance of kynurenine aminotransferase II. Biochimica Et Biophysica Acta. 1794: 1802-12. PMID 19715778 DOI: 10.1016/j.bbapap.2009.08.016  0.96
2009 Natalini B, Sardella R, Gioiello A, Carbone G, Dawgul M, Pellicciari R. Side-chain modified bile acids: chromatographic separation of 23-methyl epimers. Journal of Separation Science. 32: 2022-33. PMID 19548211 DOI: 10.1002/jssc.200900080  0.96
2009 Carotti A, Macchiarulo A, Giacchè N, Pellicciari R. Targeting the conformational transitions of MDM2 and MDMX: insights into key residues affecting p53 recognition. Proteins. 77: 524-35. PMID 19507240 DOI: 10.1002/prot.22464  0.96
2009 Macchiarulo A, Pellicciari R. MDM2/MDMX inhibitor peptide: WO2008106507. Expert Opinion On Therapeutic Patents. 19: 721-6. PMID 19441944 DOI: 10.1517/13543770902755137  0.96
2009 Moroni F, Formentini L, Gerace E, Camaioni E, Pellegrini-Giampietro DE, Chiarugi A, Pellicciari R. Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage. British Journal of Pharmacology. 157: 854-62. PMID 19422384 DOI: 10.1111/j.1476-5381.2009.00232.x  0.96
2009 Formentini L, Macchiarulo A, Cipriani G, Camaioni E, Rapizzi E, Pellicciari R, Moroni F, Chiarugi A. Poly(ADP-ribose) catabolism triggers AMP-dependent mitochondrial energy failure. The Journal of Biological Chemistry. 284: 17668-76. PMID 19411252 DOI: 10.1074/jbc.M109.002931  0.96
2009 Gioiello A, Venturoni F, Natalini B, Pellicciari R. BF(3).Et(2)O-induced decomposition of ethyl 2-diazo-3-hydroxy-3,3-diarylpropanoates in acetonitrile: a novel approach to 2,3-diaryl beta-enamino ester derivatives. The Journal of Organic Chemistry. 74: 3520-3. PMID 19341244 DOI: 10.1021/jo802775q  0.96
2009 Natalini B, Sardella R, Carbone G, Macchiarulo A, Pellicciari R. The effect of the copper(II) salt anion in the Chiral Ligand-Exchange Chromatography of amino acids. Analytica Chimica Acta. 638: 225-33. PMID 19327465 DOI: 10.1016/j.aca.2009.02.031  0.96
2009 Macchiarulo A, Nuti R, Eren G, Pellicciari R. Charting the chemical space of target sites: insights into the binding modes of amine and amidine groups. Journal of Chemical Information and Modeling. 49: 900-12. PMID 19292498 DOI: 10.1021/ci800414v  0.96
2009 Amori L, Guidetti P, Pellicciari R, Kajii Y, Schwarcz R. On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo. Journal of Neurochemistry. 109: 316-25. PMID 19226371 DOI: 10.1111/j.1471-4159.2009.05893.x  0.96
2009 Zmarowski A, Wu HQ, Brooks JM, Potter MC, Pellicciari R, Schwarcz R, Bruno JP. Astrocyte-derived kynurenic acid modulates basal and evoked cortical acetylcholine release. The European Journal of Neuroscience. 29: 529-38. PMID 19187269 DOI: 10.1111/j.1460-9568.2008.06594.x  0.96
2009 Amori L, Wu HQ, Marinozzi M, Pellicciari R, Guidetti P, Schwarcz R. Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum. Neuroscience. 159: 196-203. PMID 19138730 DOI: 10.1016/j.neuroscience.2008.11.055  0.96
2009 Natalini B, Sardella R, Camaioni E, Macchiarulo A, Gioiello A, Carbone G, Pellicciari R. Derived chromatographic indices as effective tools to study the self-aggregation process of bile acids. Journal of Pharmaceutical and Biomedical Analysis. 50: 613-21. PMID 19081222 DOI: 10.1016/j.jpba.2008.10.035  0.96
2009 Filosa R, Carmela Fulco M, Marinozzi M, Giacchè N, Macchiarulo A, Peduto A, Massa A, de Caprariis P, Thomsen C, Christoffersen CT, Pellicciari R. Design, synthesis and biological evaluation of novel bicyclo[1.1.1]pentane-based omega-acidic amino acids as glutamate receptors ligands. Bioorganic & Medicinal Chemistry. 17: 242-50. PMID 19042134 DOI: 10.1016/j.bmc.2008.11.015  0.96
2009 Macchiarulo A, Camaioni E, Nuti R, Pellicciari R. Highlights at the gate of tryptophan catabolism: a review on the mechanisms of activation and regulation of indoleamine 2,3-dioxygenase (IDO), a novel target in cancer disease. Amino Acids. 37: 219-29. PMID 18612775 DOI: 10.1007/s00726-008-0137-3  0.96
2009 Gioiello A, Khamidullina A, Fulco MC, Venturoni F, Zlotsky S, Pellicciari R. New one-pot synthesis of pyrazole-5-carboxylates by 1,3-dipole cycloadditions of ethyl diazoacetate with α-methylene carbonyl compounds Tetrahedron Letters. 50: 5978-5980. DOI: 10.1016/j.tetlet.2009.07.152  0.96
2009 Fulco MC, Marinozzi M, Çaliskan Ergün B, Sardella R, Natalini B, Pellicciari R. Synthesis and chromatographic resolution of conformationally constrained analogues of homotaurine Tetrahedron. 65: 8756-8762. DOI: 10.1016/j.tet.2009.08.018  0.96
2009 Marinozzi M, Fulco MC, Amori L, Fiumi M, Pellicciari R. Exploring the metal-catalyzed reaction of furans with alkyl α-diazomethanesulfonate and α-diazomethanephosphonate: synthesis of ω-acyl-substituted sulfono- and phosphonobutadienes Tetrahedron. 65: 7092-7098. DOI: 10.1016/j.tet.2009.06.040  0.96
2008 Macchiarulo A, Giacchè N, Carotti A, Baroni M, Cruciani G, Pellicciari R. Targeting the conformational transitions of MDM2 and MDMX: insights into dissimilarities and similarities of p53 recognition. Journal of Chemical Information and Modeling. 48: 1999-2009. PMID 18826207 DOI: 10.1021/ci800146m  0.96
2008 Dawson MI, Xia Z, Jiang T, Ye M, Fontana JA, Farhana L, Patel B, Xue LP, Bhuiyan M, Pellicciari R, Macchiarulo A, Nuti R, Zhang XK, Han YH, Tautz L, et al. Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and inhibition of SRC homology 2 domain-containing protein tyrosine phosphatase-2 activity. Journal of Medicinal Chemistry. 51: 5650-62. PMID 18759424 DOI: 10.1021/jm800456k  0.96
2008 Macchiarulo A, Gioiello A, Thomas C, Massarotti A, Nuti R, Rosatelli E, Sabbatini P, Schoonjans K, Auwerx J, Pellicciari R. Molecular field analysis and 3D-quantitative structure-activity relationship study (MFA 3D-QSAR) unveil novel features of bile acid recognition at TGR5. Journal of Chemical Information and Modeling. 48: 1792-801. PMID 18698841 DOI: 10.1021/ci800196h  0.96
2008 Thomas C, Pellicciari R, Pruzanski M, Auwerx J, Schoonjans K. Targeting bile-acid signalling for metabolic diseases. Nature Reviews. Drug Discovery. 7: 678-93. PMID 18670431 DOI: 10.1038/nrd2619  0.96
2008 Natalini B, Macchiarulo A, Sardella R, Massarotti A, Pellicciari R. Descriptive structure-separation relationship studies in chiral ligand-exchange chromatography. Journal of Separation Science. 31: 2395-403. PMID 18646268 DOI: 10.1002/jssc.200800102  0.96
2008 Natalini B, Sardella R, Macchiarulo A, Pellicciari R. Cysteine-based chiral selectors for the ligand-exchange separation of amino acids. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 875: 108-17. PMID 18579457 DOI: 10.1016/j.jchromb.2008.06.007  0.96
2008 Pellicciari R, Venturoni F, Bellocchi D, Carotti A, Marinozzi M, Macchiarulo A, Amori L, Schwarcz R. Sequence variants in kynurenine aminotransferase II (KAT II) orthologs determine different potencies of the inhibitor S-ESBA. Chemmedchem. 3: 1199-202. PMID 18537204 DOI: 10.1002/cmdc.200800109  0.96
2008 Pellicciari R, Camaioni E, Costantino G, Formentini L, Sabbatini P, Venturoni F, Eren G, Bellocchi D, Chiarugi A, Moroni F. On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives. Chemmedchem. 3: 914-23. PMID 18409175 DOI: 10.1002/cmdc.200800010  0.96
2008 Sato H, Macchiarulo A, Thomas C, Gioiello A, Une M, Hofmann AF, Saladin R, Schoonjans K, Pellicciari R, Auwerx J. Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies. Journal of Medicinal Chemistry. 51: 1831-41. PMID 18307294 DOI: 10.1021/jm7015864  0.96
2008 Natalini B, Sardella R, Macchiarulo A, Pellicciari R. S-trityl-(R)-cysteine, a powerful chiral selector for the analytical and preparative ligand-exchange chromatography of amino acids. Journal of Separation Science. 31: 696-704. PMID 18266296 DOI: 10.1002/jssc.200700511  0.96
2008 Sato H, Macchiarulo A, Thomas C, Gioiello A, Une M, Hofmann AF, Saladin R, Schoonjans K, Pellicciari R, Auwerx J. Novel potent and selective bile acid derivatives as TGR5 agonists: Biological screening, structure-activity relationships, and molecular modeling studies (Journal of Medicinal Chemistry (2008) 51, (1834)) Journal of Medicinal Chemistry. 51: 4849. DOI: 10.1021/jm8007135  0.96
2007 Pellicciari R, Marinozzi M, Macchiarulo A, Fulco MC, Gafarova J, Serpi M, Giorgi G, Nielsen S, Thomsen C. Synthesis, molecular modeling studies, and preliminary pharmacological characterization of all possible 2-(2'-sulfonocyclopropyl)glycine stereoisomers as conformationally constrained L-homocysteic acid analogs. Journal of Medicinal Chemistry. 50: 4630-41. PMID 17725337 DOI: 10.1021/jm070322e  0.96
2007 Pellicciari R, Sato H, Gioiello A, Costantino G, Macchiarulo A, Sadeghpour BM, Giorgi G, Schoonjans K, Auwerx J. Nongenomic actions of bile acids. Synthesis and preliminary characterization of 23- and 6,23-alkyl-substituted bile acid derivatives as selective modulators for the G-protein coupled receptor TGR5. Journal of Medicinal Chemistry. 50: 4265-8. PMID 17685603 DOI: 10.1021/jm070633p  0.96
2007 Macchiarulo A, Nuti R, Bellocchi D, Camaioni E, Pellicciari R. Molecular docking and spatial coarse graining simulations as tools to investigate substrate recognition, enhancer binding and conformational transitions in indoleamine-2,3-dioxygenase (IDO). Biochimica Et Biophysica Acta. 1774: 1058-68. PMID 17644054 DOI: 10.1016/j.bbapap.2007.06.007  0.96
2007 Natalini B, Sardella R, Camaioni E, Gioiello A, Pellicciari R. Correlation between CMC and chromatographic index: simple and effective evaluation of the hydrophobic/hydrophilic balance of bile acids. Analytical and Bioanalytical Chemistry. 388: 1681-8. PMID 17572887 DOI: 10.1007/s00216-007-1360-6  0.96
2007 Macchiarulo A, Pellicciari R. Exploring the other side of biologically relevant chemical space: insights into carboxylic, sulfonic and phosphonic acid bioisosteric relationships. Journal of Molecular Graphics & Modelling. 26: 728-39. PMID 17544772 DOI: 10.1016/j.jmgm.2007.04.010  0.96
2007 Chirico F, Fumelli C, Marconi A, Tinari A, Straface E, Malorni W, Pellicciari R, Pincelli C. Carboxyfullerenes localize within mitochondria and prevent the UVB-induced intrinsic apoptotic pathway. Experimental Dermatology. 16: 429-36. PMID 17437486 DOI: 10.1111/j.1600-0625.2007.00545.x  0.96
2007 Marinozzi M, Serpi M, Amori L, Gavilan Diaz M, Costantino G, Meyer U, Flor PJ, Gasparini F, Heckendorn R, Kuhn R, Giorgi G, Hermit MB, Thomsen C, Pellicciari R. Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines. Bioorganic & Medicinal Chemistry. 15: 3161-70. PMID 17350267 DOI: 10.1016/j.bmc.2007.02.040  0.96
2007 Natalini B, Sardella R, Macchiarulo A, Natalini S, Pellicciari R. (S)-(-)-alpha,alpha-Di(2-naphthyl)-2-pyrrolidinemethanol, a useful tool to study the recognition mechanism in chiral ligand-exchange chromatography. Journal of Separation Science. 30: 21-7. PMID 17313137 DOI: 10.1002/jssc.200600242  0.96
2007 Ceresoli-Borroni G, Guidetti P, Amori L, Pellicciari R, Schwarcz R. Perinatal kynurenine 3-hydroxylase inhibition in rodents: pathophysiological implications. Journal of Neuroscience Research. 85: 845-54. PMID 17279543 DOI: 10.1002/jnr.21183  0.96
2007 Pellicciari R, Amori L, Kuznetsova N, Zlotsky S, Gioiello A. Indium triflate catalyzed reaction of diisopropyl diazomethylphosphonate with imines as a new approach to cis- and trans-aziridine-2-phosphonates Tetrahedron Letters. 48: 4911-4914. DOI: 10.1016/j.tetlet.2007.05.042  0.96
2006 Ferrari C, Macchiarulo A, Costantino G, Pellicciari R. Pharmacophore model for bile acids recognition by the FPR receptor. Journal of Computer-Aided Molecular Design. 20: 295-303. PMID 16972170 DOI: 10.1007/s10822-006-9055-1  0.96
2006 Bellocchi D, Costantino G, Pellicciari R, Re N, Marrone A, Coletti C. Poly(ADP-ribose)-polymerase-catalyzed hydrolysis of NAD+: QM/MM simulation of the enzyme reaction. Chemmedchem. 1: 533-9. PMID 16892389 DOI: 10.1002/cmdc.200500061  0.96
2006 Pellicciari R, Rizzo RC, Costantino G, Marinozzi M, Amori L, Guidetti P, Wu HQ, Schwarcz R. Modulators of the kynurenine pathway of tryptophan metabolism: synthesis and preliminary biological evaluation of (S)-4-(ethylsulfonyl)benzoylalanine, a potent and selective kynurenine aminotransferase II (KAT II) inhibitor. Chemmedchem. 1: 528-31. PMID 16892388 DOI: 10.1002/cmdc.200500095  0.96
2006 Pellicciari R, Filosa R, Fulco MC, Marinozzi M, Macchiarulo A, Novak C, Natalini B, Hermit MB, Nielsen S, Sager TN, Stensbøl TB, Thomsen C. Synthesis and preliminary biological evaluation of 2'-substituted 2-(3'-carboxybicyclo[1.1.1]pentyl)glycine derivatives as group I selective metabotropic glutamate receptor ligands. Chemmedchem. 1: 358-65. PMID 16892370 DOI: 10.1002/cmdc.200500071  0.96
2006 Pellicciari R, Gioiello A, Costantino G, Sadeghpour BM, Rizzo G, Meyer U, Parks DJ, Entrena-Guadix A, Fiorucci S. Back door modulation of the farnesoid X receptor: design, synthesis, and biological evaluation of a series of side chain modified chenodeoxycholic acid derivatives. Journal of Medicinal Chemistry. 49: 4208-15. PMID 16821780 DOI: 10.1021/jm060294k  0.96
2006 Rizzo G, Disante M, Mencarelli A, Renga B, Gioiello A, Pellicciari R, Fiorucci S. The farnesoid X receptor promotes adipocyte differentiation and regulates adipose cell function in vivo. Molecular Pharmacology. 70: 1164-73. PMID 16778009 DOI: 10.1124/mol.106.023820  0.96
2006 Natalini B, Sardella R, Macchiarulo A, Pellicciari R. Dynamic ligand-exchange chiral stationary phase from S-benzyl-(R)-cysteine. Chirality. 18: 509-18. PMID 16634129 DOI: 10.1002/chir.20280  0.96
2006 Clerici C, Castellani D, Asciutti S, Pellicciari R, Setchell KD, O'Connell NC, Sadeghpour B, Camaioni E, Fiorucci S, Renga B, Nardi E, Sabatino G, Clementi M, Giuliano V, Baldoni M, et al. 3alpha-6alpha-Dihydroxy-7alpha-fluoro-5beta-cholanoate (UPF-680), physicochemical and physiological properties of a new fluorinated bile acid that prevents 17alpha-ethynyl-estradiol-induced cholestasis in rats. Toxicology and Applied Pharmacology. 214: 199-208. PMID 16487557 DOI: 10.1016/j.taap.2005.12.017  0.96
2006 Filosa R, Marinozzi M, Costantino G, Hermit MB, Thomsen C, Pellicciari R. Synthesis and biological evaluation of (2S)- and (2R)-2-(3'-phosphonobicyclo[1.1.1]pentyl)glycines as novel group III selective metabotropic glutamate receptor ligands. Bioorganic & Medicinal Chemistry. 14: 3811-7. PMID 16460952 DOI: 10.1016/j.bmc.2006.01.027  0.96
2006 Macchiarulo A, Rizzo G, Costantino G, Fiorucci S, Pellicciari R. Unveiling hidden features of orphan nuclear receptors: the case of the small heterodimer partner (SHP). Journal of Molecular Graphics & Modelling. 24: 362-72. PMID 16288980 DOI: 10.1016/j.jmgm.2005.09.016  0.96
2006 Amori L, Serpi M, Marinozzi M, Costantino G, Diaz MG, Hermit MB, Thomsen C, Pellicciari R. Synthesis and preliminary biological evaluation of (2S,1'R,2'S)- and (2S,1'S,2'R)-2-(2'-phosphonocyclopropyl)glycines, two novel conformationally constrained l-AP4 analogues. Bioorganic & Medicinal Chemistry Letters. 16: 196-9. PMID 16213710 DOI: 10.1016/j.bmcl.2005.09.014  0.96
2006 Sapko MT, Guidetti P, Yu P, Tagle DA, Pellicciari R, Schwarcz R. Endogenous kynurenate controls the vulnerability of striatal neurons to quinolinate: Implications for Huntington's disease. Experimental Neurology. 197: 31-40. PMID 16099455 DOI: 10.1016/j.expneurol.2005.07.004  0.96
2006 Pellicciari R, Gioiello A, Costantino G. Potential therapeutic applications of farnesoid X receptor (FXR) modulators Expert Opinion On Therapeutic Patents. 16: 333-341. DOI: 10.1517/13543776.16.3.333  0.96
2006 Natalini B, Sardella R, Camaioni E, Natalini S, Pellicciari R. Dominant factors affecting the chromatographic behaviour of bile acids Chromatographia. 64: 343-349. DOI: 10.1365/s10337-006-0013-9  0.96
2005 Meyer U, Costantino G, Macchiarulo A, Pellicciari R. Is antagonism of E/Z-guggulsterone at the farnesoid X receptor mediated by a noncanonical binding site? A molecular modeling study. Journal of Medicinal Chemistry. 48: 6948-55. PMID 16250653 DOI: 10.1021/jm0505056  0.96
2005 Rizzo G, Renga B, Mencarelli A, Pellicciari R, Fiorucci S. Role of FXR in regulating bile acid homeostasis and relevance for human diseases. Current Drug Targets. Immune, Endocrine and Metabolic Disorders. 5: 289-303. PMID 16178789 DOI: 10.2174/1568008054863781  0.96
2005 Pellicciari R, Costantino G, Fiorucci S. Farnesoid X receptor: from structure to potential clinical applications. Journal of Medicinal Chemistry. 48: 5383-403. PMID 16107136 DOI: 10.1021/jm0582221  0.96
2005 Fiorucci S, Rizzo G, Antonelli E, Renga B, Mencarelli A, Riccardi L, Morelli A, Pruzanski M, Pellicciari R. Cross-talk between farnesoid-X-receptor (FXR) and peroxisome proliferator-activated receptor gamma contributes to the antifibrotic activity of FXR ligands in rodent models of liver cirrhosis. The Journal of Pharmacology and Experimental Therapeutics. 315: 58-68. PMID 15980055 DOI: 10.1124/jpet.105.085597  0.96
2005 Rizzo G, Renga B, Antonelli E, Passeri D, Pellicciari R, Fiorucci S. The methyl transferase PRMT1 functions as co-activator of farnesoid X receptor (FXR)/9-cis retinoid X receptor and regulates transcription of FXR responsive genes. Molecular Pharmacology. 68: 551-8. PMID 15911693 DOI: 10.1124/mol.105.012104  0.96
2005 Fiorucci S, Rizzo G, Antonelli E, Renga B, Mencarelli A, Riccardi L, Orlandi S, Pruzanski M, Morelli A, Pellicciari R. A farnesoid x receptor-small heterodimer partner regulatory cascade modulates tissue metalloproteinase inhibitor-1 and matrix metalloprotease expression in hepatic stellate cells and promotes resolution of liver fibrosis. The Journal of Pharmacology and Experimental Therapeutics. 314: 584-95. PMID 15860571 DOI: 10.1124/jpet.105.084905  0.96
2005 Costantino G, Entrena-Guadix A, Macchiarulo A, Gioiello A, Pellicciari R. Molecular dynamics simulation of the ligand binding domain of farnesoid X receptor. Insights into helix-12 stability and coactivator peptide stabilization in response to agonist binding. Journal of Medicinal Chemistry. 48: 3251-9. PMID 15857131 DOI: 10.1021/jm049182o  0.96
2005 Bellocchi D, Macchiarulo A, Costantino G, Pellicciari R. Docking studies on PARP-1 inhibitors: insights into the role of a binding pocket water molecule. Bioorganic & Medicinal Chemistry. 13: 1151-7. PMID 15670923 DOI: 10.1016/j.bmc.2004.11.024  0.96
2005 Fiorucci S, Clerici C, Antonelli E, Orlandi S, Goodwin B, Sadeghpour BM, Sabatino G, Russo G, Castellani D, Willson TM, Pruzanski M, Pellicciari R, Morelli A. Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis. The Journal of Pharmacology and Experimental Therapeutics. 313: 604-12. PMID 15644430 DOI: 10.1124/jpet.104.079665  0.96
2005 Kauffman JM, Pellicciari R, Carey MC. Interfacial properties of most monofluorinated bile acids deviate markedly from the natural congeners: studies with the Langmuir-Pockels surface balance. Journal of Lipid Research. 46: 571-81. PMID 15604514 DOI: 10.1194/jlr.M400439-JLR200  0.96
2005 Jirgensons A, Marinozzi M, Pellicciari R. Conformationally constrained amino acids: Enantiodivergent synthesis of all four stereoisomers of 2-(tetrahydrofuran-2-yl)glycine Tetrahedron. 61: 373-377. DOI: 10.1016/j.tet.2004.10.091  0.96
2004 Fiorucci S, Antonelli E, Rizzo G, Renga B, Mencarelli A, Riccardi L, Orlandi S, Pellicciari R, Morelli A. The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis. Gastroenterology. 127: 1497-512. PMID 15521018 DOI: 10.1053/j.gastro.2004.08.001  0.96
2004 Pleban K, Macchiarulo A, Costantino G, Pellicciari R, Chiba P, Ecker GF. Homology model of the multidrug transporter LmrA from Lactococcus lactis. Bioorganic & Medicinal Chemistry Letters. 14: 5823-6. PMID 15501048 DOI: 10.1016/j.bmcl.2004.09.040  0.96
2004 Macchiarulo A, Costantino G, Meniconi M, Pleban K, Ecker G, Bellocchi D, Pellicciari R. Insights into phenylalanine derivatives recognition of VLA-4 integrin: from a pharmacophoric study to 3D-QSAR and molecular docking analyses. Journal of Chemical Information and Computer Sciences. 44: 1829-39. PMID 15446843 DOI: 10.1021/ci049914l  0.96
2004 Pellicciari R, Costantino G, Camaioni E, Sadeghpour BM, Entrena A, Willson TM, Fiorucci S, Clerici C, Gioiello A. Bile acid derivatives as ligands of the farnesoid X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues of chenodeoxycholic acid. Journal of Medicinal Chemistry. 47: 4559-69. PMID 15317466 DOI: 10.1021/jm049904b  0.96
2004 Natalini B, Marinozzi M, Sardella R, Macchiarulo A, Pellicciari R. Evaluation of the enantiomeric selectivity in the chiral ligand-exchange chromatography of amino acids by a computational model. Journal of Chromatography. A. 1033: 363-7. PMID 15088759 DOI: 10.1016/j.chroma.2004.01.054  0.96
2004 Natalini B, Marinozzi M, Bade K, Sardella R, Thomsen C, Pellicciari R. Preparative resolution of 1-aminoindan-1,5-dicarboxylic acid (AIDA) by chiral ligand-exchange chromatography. Chirality. 16: 314-7. PMID 15069662 DOI: 10.1002/chir.20027  0.96
2004 Macchiarulo A, De Luca L, Costantino G, Barreca ML, Gitto R, Pellicciari R, Chimirri A. QSAR study of anticonvulsant negative allosteric modulators of the AMPA receptor. Journal of Medicinal Chemistry. 47: 1860-3. PMID 15027880 DOI: 10.1021/jm0310838  0.96
2004 Pellicciari R, Camaioni E, Costantino G. 3. Life or death decisions: the cast of poly(ADP-ribose)polymerase (PARP) as a therapeutic target for brain ischaemia. Progress in Medicinal Chemistry. 42: 125-69. PMID 15003720 DOI: 10.1016/S0079-6468(04)42003-7  0.96
2004 Costantino G, Marinozzi M, Camaioni E, Natalini B, Sarichelou I, Micheli F, Cavanni P, Faedo S, Noe C, Moroni F, Pellicciari R. Stereoselective synthesis and preliminary evaluation of (+)- and (-)-3-methyl-5-carboxy-thien-2-yl-glycine (3-MATIDA): identification of (+)-3-MATIDA as a novel mGluR1 competitive antagonist. Farmaco (Società Chimica Italiana : 1989). 59: 93-9. PMID 14871500 DOI: 10.1016/j.farmac.2003.11.008  0.96
2004 Gaviraghi G, Pellicciari R. Drug discovery: Back and forward Medicinal Chemistry Research. 13: 216-217. DOI: 10.1007/s00044-004-0028-4  0.96
2004 Marinozzi M, Fulco MC, Rizzo R, Pellicciari R. Synthesis of novel unsymmetrically bridgehead-substituted phenylseleno-bicyclo[1.1.1]pentanes Synlett. 1027-1028.  0.96
2003 Pellicciari R, Amori L, Costantino G, Giordani A, Macchiarulo A, Mattoli L, Pevarello P, Speciale C, Varasi M. Modulation of the kynurine pathway of tryptophan metabolism in search for neuroprotective agents. Focus on kynurenine-3-hydroxylase. Advances in Experimental Medicine and Biology. 527: 621-8. PMID 15206781  0.96
2003 Belenikin MS, Costantino G, Palyulin VA, Pellicciari R, Zefirov NS. Molecular modeling of the mGluR1 metabotropic glutamate receptor transmembrane domain and construction of the model of its dimer. Doklady. Biochemistry and Biophysics. 393: 341-5. PMID 14870616 DOI: 10.1023/B:DOBI.0000010299.35247.fb  0.96
2003 Traversa U, Bombi G, Camaioni E, Macchiarulo A, Costantino G, Palmieri C, Caciagli F, Pellicciari R. Rat brain guanosine binding site. Biological studies and pseudo-receptor construction. Bioorganic & Medicinal Chemistry. 11: 5417-25. PMID 14642586 DOI: 10.1016/j.bmc.2003.09.043  0.96
2003 Pellicciari R, Camaioni E, Costantino G, Marinozzi M, Macchiarulo A, Moroni F, Natalini B. Towards new neuroprotective agents: design and synthesis of 4H-thieno[2,3-c] isoquinolin-5-one derivatives as potent PARP-1 inhibitors. Farmaco (Società Chimica Italiana : 1989). 58: 851-8. PMID 13679179 DOI: 10.1016/S0014-827X(03)00143-5  0.96
2003 Belenikin MS, Costantino G, Palyulin VA, Pellicciari R, Zefirov NS. Molecular dynamic simulation of the ligand-receptor complexes of the aminoterminal domain of the metabotropic glutamate receptor mGluR1. Doklady. Biochemistry and Biophysics. 389: 98-102. PMID 12856414  0.96
2003 Belenikin MS, Costantino G, Palyulin VA, Pellicciari R, Zefirov NS. Molecular modeling of the ligand-binding domains of the NR3A and NR3B subunits of the NMDA receptor. Doklady. Biochemistry and Biophysics. 389: 83-9. PMID 12856411  0.96
2003 Costantino G, Macchiarulo A, Entrena-Guadix A, Camaioni E, Pellicciari R. Binding mode of 6ECDCA, a potent bile acid agonist of the farnesoid X receptor (FXR). Bioorganic & Medicinal Chemistry Letters. 13: 1865-8. PMID 12749886 DOI: 10.1016/S0960-894X(03)00281-6  0.96
2003 Mi LZ, Devarakonda S, Harp JM, Han Q, Pellicciari R, Willson TM, Khorasanizadeh S, Rastinejad F. Structural basis for bile acid binding and activation of the nuclear receptor FXR. Molecular Cell. 11: 1093-100. PMID 12718893 DOI: 10.1016/S1097-2765(03)00112-6  0.96
2003 Chiarugi A, Meli E, Calvani M, Picca R, Baronti R, Camaioni E, Costantino G, Marinozzi M, Pellegrini-Giampietro DE, Pellicciari R, Moroni F. Novel isoquinolinone-derived inhibitors of poly(ADP-ribose) polymerase-1: pharmacological characterization and neuroprotective effects in an in vitro model of cerebral ischemia. The Journal of Pharmacology and Experimental Therapeutics. 305: 943-9. PMID 12606624 DOI: 10.1124/jpet.103.048934  0.96
2003 De Luca L, Macchiarulo A, Costantino G, Barreca ML, Gitto R, Chimirri A, Pellicciari R. Binding modes of noncompetitive AMPA antagonists: a computational approach. Farmaco (Società Chimica Italiana : 1989). 58: 107-13. PMID 12581776 DOI: 10.1016/S0014-827X(02)00027-7  0.96
2003 Macchiarulo A, Costantino G, Sbaglia R, Aiello S, Meniconi M, Pellicciari R. The role of electrostatic interaction in the molecular recognition of selective agonists to metabotropic glutamate receptors. Proteins. 50: 609-19. PMID 12577267 DOI: 10.1002/prot.10301  0.96
2003 Pellicciari R, Natalini B, Potolokova TV, Marinozzi M, Nefedova MN, Peregudov AS, Sokolov VI. Thermal and catalytic reactions of diazoacetylmetallocenes with [60]fullerene Synthetic Communications. 33: 903-914. DOI: 10.1081/SCC-120016348  0.96
2003 Pellicciari R. Il Farmaco: Foreword Farmaco. 58: 619. DOI: 10.1016/S0014-827X(03)00176-9  0.96
2003 Belenikin MS, Costantino G, Palyulin VA, Pellicciari R, Zefirov NS. Molecular modeling of the transmembrane domain of the metabotropic glutamate receptor mGluR1 and the model of its dimeric form Doklady Akademii Nauk. 393: 827-831.  0.96
2003 Belenikin MS, Costantino G, Palyulin VA, Pellicciari R, Zefirov NS. Molecular modeling of ligand-binding domains of NMDA receptor NR3A and NR3B subunits Doklady Akademii Nauk. 389: 252-259.  0.96
2003 Belenikin MS, Costantino G, Palyulin VA, Pellicciari R, Zefirov NS. Molecular dynamic simulation of ligand-receptor complexes of metabotropic glutamate receptor mGluR1 amino-terminal domain Doklady Akademii Nauk. 389: 538-544.  0.96
2002 Costantino G, Macchiarulo A, Belenikin M, Pellicciari R. Molecular dynamics simulation of the ligand binding domain of mGluR1 in response to agonist and antagonist binding. Journal of Computer-Aided Molecular Design. 16: 779-84. PMID 12825789 DOI: 10.1023/A:1023876410800  0.96
2002 Belenikin MS, Baskin II, Costantino G, Palyulin VA, Pellicciari R, Zefirov NS. Comparative analysis of the ligand-binding sites of the metabotropic glutamate receptors mGluR1-mGluR8. Doklady. Biochemistry and Biophysics. 386: 251-6. PMID 12469502  0.96
2002 Belenikin MS, Baskin II, Costantino G, Palyulin VA, Pellicciari R, Zefirov NS. Molecular modeling of the closed forms of the kainate-binding domains of kainate receptors and qualitative analysis of the structure-activity relationships for some agonists. Doklady. Biochemistry and Biophysics. 386: 239-44. PMID 12469499  0.96
2002 Schwarcz R, Pellicciari R. Manipulation of brain kynurenines: glial targets, neuronal effects, and clinical opportunities. The Journal of Pharmacology and Experimental Therapeutics. 303: 1-10. PMID 12235226 DOI: 10.1124/jpet.102.034439  0.96
2002 Cozzi A, Meli E, Carlà V, Pellicciari R, Moroni F, Pellegrini-Giampietro DE. Metabotropic glutamate 1 (mGlu1) receptor antagonists enhance GABAergic neurotransmission: a mechanism for the attenuation of post-ischemic injury and epileptiform activity? Neuropharmacology. 43: 119-30. PMID 12213266 DOI: 10.1016/S0028-3908(02)00080-1  0.96
2002 Pellicciari R, Fiorucci S, Camaioni E, Clerici C, Costantino G, Maloney PR, Morelli A, Parks DJ, Willson TM. 6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity. Journal of Medicinal Chemistry. 45: 3569-72. PMID 12166927 DOI: 10.1021/jm025529g  0.96
2002 Pellicciari R, Marinozzi M, Camaioni E, del Carmen Nùnez M, Costantino G, Gasparini F, Giorgi G, Macchiarulo A, Subramanian N. Spiro[2.2]pentane as a dissymmetric scaffold for conformationally constrained analogues of glutamic acid: focus on racemic 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acids. The Journal of Organic Chemistry. 67: 5497-507. PMID 12153247 DOI: 10.1021/jo020138v  0.96
2002 Moroni F, Attucci S, Cozzi A, Meli E, Picca R, Scheideler MA, Pellicciari R, Noe C, Sarichelou I, Pellegrini-Giampietro DE. The novel and systemically active metabotropic glutamate 1 (mGlu1) receptor antagonist 3-MATIDA reduces post-ischemic neuronal death. Neuropharmacology. 42: 741-51. PMID 12015200 DOI: 10.1016/S0028-3908(02)00033-3  0.96
2002 Medici A, Pedrini P, Bianchini E, Fantin G, Guerrini A, Natalini B, Pellicciari R. 7alpha-OH epimerisation of bile acids via oxido-reduction with Xanthomonas maltophilia. Steroids. 67: 51-6. PMID 11728521 DOI: 10.1016/S0039-128X(01)00136-2  0.96
2002 Matveeva ED, Podrugina TA, Morozkina NY, Zefirova ON, Seregin IV, Bachurin SO, Pellicciari R, Zefirov NS. Syntheses of compounds active toward glutamate receptors: II. Synthesis of spiro hydantoins of the indan series Russian Journal of Organic Chemistry. 38: 1769-1774. DOI: 10.1023/A:1022567630253  0.96
2002 Matveeva ED, Podrugina TA, Zefirova ON, Alekseev AS, Bachurin SO, Pellicciari R, Zefirov NS. Syntheses of compounds active toward glutamate receptors: I. New preparative synthesis of aminoindandicarboxylic acid (AIDA) Russian Journal of Organic Chemistry. 38: 1764-1768. DOI: 10.1023/A:1022515613414  0.96
2002 Costantino G, Rovito R, Macchiarulo A, Pellicciari R. Structure of metal-carbenoid intermediates derived from the dirhodium(II)tetracarboxylate mediated decomposition of α-diazocarbonyl compounds: A DFT study Journal of Molecular Structure: Theochem. 581: 111-115. DOI: 10.1016/S0166-1280(01)00747-3  0.96
2002 Belenikin MS, Baskin II, Costantino G, Palyulin VA, Pellicciari R, Zefirov NS. Comparative analysis of ligand-binding sites of metabotropic glutamate receptors mGluR1-mGluR8 Doklady Akademii Nauk. 386: 261-267.  0.96
2002 Belenikin MS, Baskin II, Costantino G, Palyulin VA, Pellicciari R, Zefirov NS. Molecular modeling of closed forms of kainate reseptor kainite binding domains and qualitative structure-activity relationships study for a series of agonists Doklady Akademii Nauk. 386: 118-124.  0.96
2001 Costantino G, Macchiarulo A, Pellicciari R. Metabotropic glutamate receptors: targets for therapy of cerebral ischaemia. Expert Opinion On Therapeutic Targets. 5: 669-683. PMID 12540277 DOI: 10.1517/14728222.5.6.669  0.96
2001 Pellicciari R, Costantino G, Marinozzi M, Macchiarulo A, Amori L, Josef Flor P, Gasparini F, Kuhn R, Urwyler S. Design, synthesis and preliminary evaluation of novel 3'-substituted carboxycyclopropylglycines as antagonists at group 2 metabotropic glutamate receptors. Bioorganic & Medicinal Chemistry Letters. 11: 3179-82. PMID 11720869 DOI: 10.1016/S0960-894X(01)00656-4  0.96
2001 Costantino G, Macchiarulo A, Camaioni E, Pellicciari R. Modeling of poly(ADP-ribose)polymerase (PARP) inhibitors. Docking of ligands and quantitative structure-activity relationship analysis. Journal of Medicinal Chemistry. 44: 3786-94. PMID 11689065 DOI: 10.1021/jm010116l  0.96
2001 Terán Moldes MC, Costantino G, Marinozzi M, Pellicciari R. Synthesis and preliminary biological evaluation at the glycineB site of (+)- and (-)-3-oxetanylglycine, novel non-proteinogenic amino acids. Farmaco (Società Chimica Italiana : 1989). 56: 609-13. PMID 11601647 DOI: 10.1016/S0014-827X(01)01101-6  0.96
2001 Moroni F, Meli E, Peruginelli F, Chiarugi A, Cozzi A, Picca R, Romagnoli P, Pellicciari R, Pellegrini-Giampietro DE. Poly(ADP-ribose) polymerase inhibitors attenuate necrotic but not apoptotic neuronal death in experimental models of cerebral ischemia. Cell Death and Differentiation. 8: 921-32. PMID 11526447 DOI: 10.1038/sj.cdd.4400884  0.96
2001 Costantino G, Macchiarulo A, Entrena Guadix A, Pellicciari R. QSAR and molecular modeling studies of baclofen analogues as GABA(B) agonists. Insights into the role of the aromatic moiety in GABA(B) binding and activation. Journal of Medicinal Chemistry. 44: 1827-32. PMID 11356116 DOI: 10.1021/jm0100133  0.96
2001 Costantino G, Macchiarulo A, Pellicciari R. Homology model of the closed, functionally active, form of the amino terminal domain of mGlur1. Bioorganic & Medicinal Chemistry. 9: 847-52. PMID 11354667 DOI: 10.1016/S0968-0896(00)00311-4  0.96
2001 Pellicciari R, Costantino G, Marinozzi M, Macchiarulo A, Camaioni E, Natalini B. Metabotropic glutamate receptors: structure and new subtype-selective ligands. Farmaco (Società Chimica Italiana : 1989). 56: 91-4. PMID 11347974 DOI: 10.1016/S0014-827X(01)01006-0  0.96
2001 Costantino G, Maltoni K, Marinozzi M, Camaioni E, Prezeau L, Pin JP, Pellicciari R. Synthesis and biological evaluation of 2-(3'-(1H-tetrazol-5-yl) bicyclo[1.1.1]pent-1-yl)glycine (S-TBPG), a novel mGlu1 receptor antagonist. Bioorganic & Medicinal Chemistry. 9: 221-7. PMID 11249114 DOI: 10.1016/S0968-0896(00)00270-4  0.96
2001 Natalini B, Camaioni E, Colagioia S, Pellicciari R. Use of RP-HPLC on a dynamically coated artificial membrane to predict intestinal absorption of bile acids Chromatographia. 53: S453-S455. DOI: 10.1007/BF02490376  0.96
2001 Costantino G, Macchiarulo A, Pellicciari R. Metabotropic glutamate receptors: Targets for therapy of cerebral ischaemia Expert Opinion On Therapeutic Targets. 5: 669-683.  0.96
2000 Fumelli C, Marconi A, Salvioli S, Straface E, Malorni W, Offidani AM, Pellicciari R, Schettini G, Giannetti A, Monti D, Franceschi C, Pincelli C. Carboxyfullerenes protect human keratinocytes from ultraviolet-B-induced apoptosis. The Journal of Investigative Dermatology. 115: 835-41. PMID 11069621 DOI: 10.1046/j.1523-1747.2000.00140.x  0.96
2000 Monti D, Moretti L, Salvioli S, Straface E, Malorni W, Pellicciari R, Schettini G, Bisaglia M, Pincelli C, Fumelli C, Bonafè M, Franceschi C. C60 carboxyfullerene exerts a protective activity against oxidative stress-induced apoptosis in human peripheral blood mononuclear cells. Biochemical and Biophysical Research Communications. 277: 711-7. PMID 11062018 DOI: 10.1006/bbrc.2000.3715  0.96
2000 Costantino G, Wolf C, Natalini B, Pellicciari R. Evaluation of hydrophobic/hydrophilic balance of bile acids by comparative molecular field analysis (CoMFA). Steroids. 65: 483-9. PMID 10978726 DOI: 10.1016/S0039-128X(00)00108-2  0.96
2000 Amori L, Costantino G, Marinozzi M, Pellicciari R, Gasparini F, Flor PJ, Kuhn R, Vranesic I. Synthesis, molecular modeling and preliminary biological evaluation of 1-amino-3-phosphono-3-cyclopentene-1-carboxylic acid and 1-amino-3-phosphono-2-cyclopentene-1-carboxylic acid, two novel agonists of metabotropic glutamate receptors of group III. Bioorganic & Medicinal Chemistry Letters. 10: 1447-50. PMID 10888329 DOI: 10.1016/S0960-894X(00)00247-X  0.96
2000 Pellicciari R, Costantino G, Macchiarulo A. Metabotropic glutamate receptors: a structural view point. Pharmaceutica Acta Helvetiae. 74: 231-7. PMID 10812963 DOI: 10.1016/S0031-6865(99)00055-2  0.96
2000 Parmentier ML, Galvez T, Acher F, Peyre B, Pellicciari R, Grau Y, Bockaert J, Pin JP. Conservation of the ligand recognition site of metabotropic glutamate receptors during evolution. Neuropharmacology. 39: 1119-31. PMID 10760355 DOI: 10.1016/S0028-3908(99)00204-X  0.96
2000 Bisaglia M, Natalini B, Pellicciari R, Straface E, Malorni W, Monti D, Franceschi C, Schettini G. C3-fullero-tris-methanodicarboxylic acid protects cerebellar granule cells from apoptosis. Journal of Neurochemistry. 74: 1197-204. PMID 10693952  0.96
2000 Pellicciari R, Costantino G, Macchiarulo A. Metabotropic glutamate receptors: a structural view point Pharmacochemistry Library. 31: 231-237. DOI: 10.1016/S0165-7208(00)80023-9  0.96
2000 Pellicciari R, Natalini B, Amori L, Marinozzi M, Seraglia R. Synthesis of methano[60]fullerenephosphonic- and methano[60]fullerene-diphosphonic acids Synlett. 1816-1818.  0.96
2000 Marinozzi M, Pellicciari R. Novel enantioselective synthesis of (2S,2'R,3'R)-2-(2',3'-dicarboxycyclopropyl)glycine (DCG-IV) Tetrahedron Letters. 41: 9125-9128.  0.96
2000 Baskin II, Belenikin MS, Ekimova EV, Costantino G, Palyulin VA, Pellicciari R, Zefirov NS. Molecular modeling of the amino-terminal domain of the metabotropic glutamate receptor mGluR1 Doklady Chemistry. 374: 191-194.  0.96
1999 Costantino G, Macchiarulo A, Pellicciari R. Modeling of amino-terminal domains of group I metabotropic glutamate receptors: structural motifs affecting ligand selectivity. Journal of Medicinal Chemistry. 42: 5390-401. PMID 10639281 DOI: 10.1021/jm990353c  0.96
1999 Pellegrini-Giampietro DE, Cozzi A, Peruginelli F, Leonardi P, Meli E, Pellicciari R, Moroni F. 1-Aminoindan-1,5-dicarboxylic acid and (S)-(+)-2-(3'-carboxybicyclo[1.1.1] pentyl)-glycine, two mGlu1 receptor-preferring antagonists, reduce neuronal death in in vitro and in vivo models of cerebral ischaemia. The European Journal of Neuroscience. 11: 3637-47. PMID 10564371 DOI: 10.1046/j.1460-9568.1999.00786.x  0.96
1999 Di Giacomo B, Coletta D, Natalini B, Ni MH, Pellicciari R. A new synthesis of carboxyterfenadine (fexofenadine) and its bioisosteric tetrazole analogs. Farmaco (Società Chimica Italiana : 1989). 54: 600-10. PMID 10555262 DOI: 10.1016/S0014-827X(99)00070-1  0.96
1999 Pellegrini-Giampietro DE, Peruginelli F, Meli E, Cozzi A, Albani-Torregrossa S, Pellicciari R, Moroni F. Protection with metabotropic glutamate 1 receptor antagonists in models of ischemic neuronal death: time-course and mechanisms. Neuropharmacology. 38: 1607-19. PMID 10530822 DOI: 10.1016/S0028-3908(99)00097-0  0.96
1999 Straface E, Natalini B, Monti D, Franceschi C, Schettini G, Bisaglia M, Fumelli C, Pincelli C, Pellicciari R, Malorni W. C3-fullero-tris-methanodicarboxylic acid protects epithelial cells from radiation-induced anoikia by influencing cell adhesion ability. Febs Letters. 454: 335-40. PMID 10431834 DOI: 10.1016/S0014-5793(99)00812-1  0.96
1999 Mannaioni G, Attucci S, Missanelli A, Pellicciari R, Corradetti R, Moroni F. Biochemical and electrophysiological studies on (S)-(+)-2-(3'-carboxybicyclo(1.1.1)pentyl)-glycine (CBPG), a novel mGlu5 receptor agonist endowed with mGlu1 receptor antagonist activity. Neuropharmacology. 38: 917-26. PMID 10428410 DOI: 10.1016/S0028-3908(99)00021-0  0.96
1999 Costantino G, Macchiarulo A, Pellicciari R. Pharmacophore models of group I and group II metabotropic glutamate receptor agonists. Analysis of conformational, steric, and topological parameters affecting potency and selectivity. Journal of Medicinal Chemistry. 42: 2816-27. PMID 10425091 DOI: 10.1021/jm990182b  0.96
1999 Pellicciari R, Costantino G. Metabotropic G-protein-coupled glutamate receptors as therapeutic targets. Current Opinion in Chemical Biology. 3: 433-40. PMID 10419848 DOI: 10.1016/S1367-5931(99)80064-7  0.96
1999 Pellicciari R, Marinozzi M, Costantino G, Natalini B, Moroni F, Pellegrini-Giampietro D. (2R,1'S,2'R,3'S)-2-(2'-Carboxy-3'-phenylcyclopropyl)glycine (PCCG-13), the first potent and selective competitive antagonist of phospholipase D-coupled metabotropic glutamate receptors: asymmetric synthesis and preliminary biological properties. Journal of Medicinal Chemistry. 42: 2716-20. PMID 10411492 DOI: 10.1021/jm990128v  0.96
1999 Albani-Torregrossa S, Attucci S, Marinozzi M, Pellicciari R, Moroni F, Pellegrini-Giampietro DE. Antagonist pharmacology of metabotropic glutamate receptors coupled to phospholipase D activation in adult rat hippocampus: focus on (2R,1'S,2'R,3'S)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine versus 3, 5-dihydroxyphenylglycine. Molecular Pharmacology. 55: 699-707. PMID 10101028  0.96
1999 Natalini B, Capodiferro V, Mattoli L, Marinozzi M, Costantino G, Pellicciari R. Chromatographic separation and evaluation of the lipophilicity by reversed-phase high-performance liquid chromatography of fullerene-C60 derivatives Journal of Chromatography A. 847: 339-343. DOI: 10.1016/S0021-9673(99)00246-0  0.96
1998 Pellicciari R, Costantino G, Giovagnoni E, Mattoli L, Brabet I, Pin JP. Synthesis and preliminary evaluation of (S)-2-(4'-carboxycubyl)glycine, a new selective mGluR1 antagonist. Bioorganic & Medicinal Chemistry Letters. 8: 1569-74. PMID 9873392 DOI: 10.1016/S0960-894X(98)00265-0  0.96
1998 Clerici C, Gentili G, Pellicciari R, Gresele P, Mezzasoma AM, Giansanti M, Clementi M, Bartoli G, Balò S, Modesto R, Aburbeh AG, Morelli O, Morelli A. 5-ASA-glutamate protects rats from inflammatory bowel disease induced by intracolonic administration of trinitrobenzensulfonic acid. Italian Journal of Gastroenterology and Hepatology. 30: 385-90. PMID 9789134  0.96
1998 Pellicciari R, Costantino G, Marinozzi M, Mattoli L, Natalini B. α-Diazocarbonyl chemistry-Target driven applications Pharmacochemistry Library. 29: 29-47. DOI: 10.1016/S0165-7208(98)80043-3  0.96
1993 Pellicciari R, Natalini B, Costantino G, Garzon A, Luneia R, Mahmoud MR, Marinozzi M, Roberti M, Rosato GC, Shiba SA. Heterocyclic modulators of the NMDA receptor. Farmaco (Società Chimica Italiana : 1989). 48: 151-7. PMID 8494596  0.96
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