Louis J. Ignarro - Related publications

Molecular and Medical Pharmacology University of California, Los Angeles, Los Angeles, CA 
regulation and modulation of nitric oxide (NO) production and cytotoxicity in macrophages, vascular cells, and tumor cells
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50 most relevant papers in past 60 days:
Year Citation  Score
2019 Yoo OK, Keum YS. 4'-O-β-D-Glucosyl-5-O-Methylvisamminol Attenuates Pro-Inflammatory Responses and Protects against Oxidative Damage. Biomolecules & Therapeutics. PMID 30971060 DOI: 10.4062/biomolther.2018.232   
2019 Pasten C, Alvarado C, Rocco J, Contreras L, Aracena P, Liberona J, Suazo C, Michea L, Irarrázabal CE. l-NIL prevents the ischemia and reperfusion injury involving TLR-4, GST, clusterin, and NFAT-5 in mice. American Journal of Physiology. Renal Physiology. 316: F624-F634. PMID 30516425 DOI: 10.1152/ajprenal.00398.2018   
2019 Kwon DH, Cha HJ, Lee H, Hong SH, Park C, Park SH, Kim GY, Kim S, Kim HS, Hwang HJ, Choi YH. Protective Effect of Glutathione against Oxidative Stress-induced Cytotoxicity in RAW 264.7 Macrophages through Activating the Nuclear Factor Erythroid 2-Related Factor-2/Heme Oxygenase-1 Pathway. Antioxidants (Basel, Switzerland). 8. PMID 30939721 DOI: 10.3390/antiox8040082   
2019 Kim JH, Lee S, Cho EJ. protects SH-SY5Y neuronal cells against hydrogen peroxide-induced oxidative stress. Food Science and Biotechnology. 28: 191-200. PMID 30815310 DOI: 10.1007/s10068-018-0381-6   
2019 Zhang Y, Ahmad KA, Khan FU, Yan S, Ihsan AU, Ding Q. Chitosan oligosaccharides prevent doxorubicin-induced oxidative stress and cardiac apoptosis through activating p38 and JNK MAPK mediated Nrf2/ARE pathway. Chemico-Biological Interactions. PMID 30928397 DOI: 10.1016/j.cbi.2019.03.027   
2019 Gho Y, Shin SS, Choi YH, Ko K, Kim WJ, Moon SK. Hydrangenol suppresses VEGF-stimulated angiogenesis by targeting p27KIP1-dependent G1-cell cycle arrest, VEGFR-2-mediated signaling, and MMP-2 expression. Animal Cells and Systems. 23: 72-81. PMID 30949393 DOI: 10.1080/19768354.2019.1578262   
2019 Sun W, Gao Y, Ding Y, Cao Y, Chen J, Lv G, Lu J, Yu B, Peng M, Xu H, Sun Y. Catalpol ameliorates advanced glycation end product-induced dysfunction of glomerular endothelial cells via regulating nitric oxide synthesis by inducible nitric oxide synthase and endothelial nitric oxide synthase. Iubmb Life. PMID 30861639 DOI: 10.1002/iub.2032   
2019 Ou HC, Pandey S, Hung MY, Huang SH, Hsu PT, Day CH, Pai P, Padma Viswanadha V, Kuo WW, Huang CY. Luteolin: A Natural Flavonoid Enhances the Survival of HUVECs against Oxidative Stress by Modulating AMPK/PKC Pathway. The American Journal of Chinese Medicine. 1-17. PMID 30966772 DOI: 10.1142/S0192415X19500289   
2019 Oh Y, Ahn CB, Nam KH, Kim YK, Yoon NY, Je JY. Amino Acid Composition, Antioxidant, and Cytoprotective Effect of Blue Mussel () Hydrolysate through the Inhibition of Caspase-3 Activation in Oxidative Stress-Mediated Endothelial Cell Injury. Marine Drugs. 17. PMID 30823522 DOI: 10.3390/md17020135   
2019 Guo H, Verhoek I, Prins G, van der Vlag R, van der Wouden PE, van Merkerk R, Quax WJ, Olinga P, Hirsch AKH, Dekker FJ. A novel 15-Lipoxygenase-1 Inhibitor Protects Macrophages from Lipopolysaccharides-Induced Cytotoxicity. Journal of Medicinal Chemistry. PMID 30964295 DOI: 10.1021/acs.jmedchem.9b00212   
2019 Meurer MC, Mees M, Mariano LNB, Boeing T, Somensi LB, Mariott M, da Silva RCMVAF, Dos Santos AC, Longo B, Santos França TC, Klein-Júnior LC, de Souza P, de Andrade SF, da Silva LM. Hydroalcoholic extract of Tagetes erecta L. flowers, rich in the carotenoid lutein, attenuates inflammatory cytokine secretion and improves the oxidative stress in an animal model of ulcerative colitis. Nutrition Research (New York, N.Y.). PMID 30979660 DOI: 10.1016/j.nutres.2019.03.005   
2019 Zhang Y, Li C, Zhou C, Hong P, Zhang Y, Sun S, Qian ZJ. 2'-Hydroxy-5'-methoxyacetophenone attenuates the inflammatory response in LPS-induced BV-2 and RAW264.7 cells via NF-κB signaling pathway. Journal of Neuroimmunology. 330: 143-151. PMID 30884275 DOI: 10.1016/j.jneuroim.2019.03.009   
2019 Sannasimuthu A, Kumaresan V, Anilkumar S, Pasupuleti M, Ganesh MR, Mala K, Paray BA, Al-Sadoon MK, Albeshr MF, Arockiaraj J. Design and characterization of a novel Arthrospira platensis glutathione oxido-reductase-derived antioxidant peptide GM15 and its potent anti-cancer activity via caspase-9 mediated apoptosis in oral cancer cells. Free Radical Biology & Medicine. PMID 30862544 DOI: 10.1016/j.freeradbiomed.2019.03.006   
2019 Yang P, Zhou Y, Xia Q, Yao L, Chang X. Astragaloside IV regulates the PI3K/Akt/HO-1 signaling pathway and inhibits H9c2 cardiomyocyte injury induced by hypoxia-reoxygenation. Biological & Pharmaceutical Bulletin. PMID 30867343 DOI: 10.1248/bpb.b18-00854   
2019 Chu Q, Zhang S, Yu L, Li Y, Liu Y, Ye X, Zheng X. Apios americana Medikus tuber polysaccharide exerts anti-inflammatory effects by activating autophagy. International Journal of Biological Macromolecules. PMID 30840871 DOI: 10.1016/j.ijbiomac.2019.03.012   
2019 Park EJ, Seong E, Kim Y, Lee K. Ammonium lauryl sulfate-induced apoptotic cell death may be due to mitochondrial dysfunction triggered by caveolin-1. Toxicology in Vitro : An International Journal Published in Association With Bibra. PMID 30825645 DOI: 10.1016/j.tiv.2019.02.021   
2019 Yang X, He T, Han S, Zhang X, Sun Y, Xing Y, Shang H. The Role of Traditional Chinese Medicine in the Regulation of Oxidative Stress in Treating Coronary Heart Disease. Oxidative Medicine and Cellular Longevity. 2019: 3231424. PMID 30918578 DOI: 10.1155/2019/3231424   
2019 Zhou J, Wang T, Wang H, Jiang Y, Peng S. Obacunone attenuates high glucose-induced oxidative damage in NRK-52E cells by inhibiting the activity of GSK-3β. Biochemical and Biophysical Research Communications. PMID 30954216 DOI: 10.1016/j.bbrc.2019.03.201   
2019 Wang Y, Li Y, Yang Z, Wang Z, Chang J, Zhang T, Chi Y, Han N, Zhao K. Pyridoxamine Treatment of HK-2 Human Proximal Tubular Epithelial Cells Reduces Oxidative Stress and the Inhibition of Autophagy Induced by High Glucose Levels. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research. 25: 1480-1488. PMID 30799433 DOI: 10.12659/MSM.914799   
2019 Van Thanh N, Jang HJ, Vinh LB, Linh KTP, Huong PTT, Cuong NX, Nam NH, Van Minh C, Kim YH, Yang SY. Chemical constituents from Vietnamese mangrove Calophyllum inophyllum and their anti-inflammatory effects. Bioorganic Chemistry. 88: 102921. PMID 30991191 DOI: 10.1016/j.bioorg.2019.102921   
2019 Hwang SD, Song JH, Kim Y, Lim JH, Kim MY, Kim EN, Hong YA, Chung S, Choi BS, Kim YS, Park CW. Inhibition of lymphatic proliferation by the selective VEGFR-3 inhibitor SAR131675 ameliorates diabetic nephropathy in db/db mice. Cell Death & Disease. 10: 219. PMID 30833548 DOI: 10.1038/s41419-019-1436-1   
2019 Reyes L, Hawkins CL, Rayner BS. Characterization of the cellular effects of myeloperoxidase-derived oxidants on H9c2 cardiac myoblasts. Archives of Biochemistry and Biophysics. PMID 30872062 DOI: 10.1016/j.abb.2019.03.004   
2019 Pengzong Z, Yuanmin L, Xiaoming X, Shang D, Wei X, Zhigang L, Dongzhou D, Wenjing Y, Jianbiao Y, Yang X, Xia L. Wound Healing Potential of the Standardized Extract of Boswellia serrata on Experimental Diabetic Foot Ulcer via Inhibition of Inflammatory, Angiogenetic and Apoptotic Markers. Planta Medica. PMID 30909313 DOI: 10.1055/a-0881-3000   
2019 Pormehr M, Ghanati F, Sharifi M, McCabe PF, Hosseinkhani S, Zare-Maivan H. The role of SIPK signaling pathway in antioxidant activity and programmed cell death of tobacco cells after exposure to cadmium. Plant Science : An International Journal of Experimental Plant Biology. 280: 416-423. PMID 30824021 DOI: 10.1016/j.plantsci.2018.12.028   
2019 Vallejos A, Olivares P, Gatica S, Villegas V, Echeverria C, Cabello-Verrugio C, Simon F. Endotoxemia-induced endothelial fibrosis inhibition improves hypotension, tachycardia, multiple organ dysfunction syndrome, cytokine response, oxidative stress, and survival. Laboratory Investigation; a Journal of Technical Methods and Pathology. PMID 30911151 DOI: 10.1038/s41374-019-0237-6   
2019 Attanzio A, Frazzitta A, Busa' R, Tesoriere L, Livrea MA, Allegra M. Indicaxanthin from (L. Mill) Inhibits Oxidized LDL-Mediated Human Endothelial Cell Dysfunction through Inhibition of NF-B Activation. Oxidative Medicine and Cellular Longevity. 2019: 3457846. PMID 30911345 DOI: 10.1155/2019/3457846   
2019 Zhang Q, Liu H, Yang J. Regulation of TGF-β1 on PI3KC3 and its role in hypertension-induced vascular injuries. Experimental and Therapeutic Medicine. 17: 1717-1727. PMID 30783440 DOI: 10.3892/etm.2018.7128   
2019 Al-Salam S, Aburawi EH, Al-Hammadi S, Dhanasekaran S, Shafiuallah M, Yasin J, Sudhadevi M, Awwad A, Alper SL, Kazzam EE, Bellou A. Cellular and Immunohistochemical Changes in Anaphylactic Shock Induced in the Ovalbumin-Sensitized Wistar Rat Model. Biomolecules. 9. PMID 30871269 DOI: 10.3390/biom9030101   
2019 Yu H, Kalogeris T, Korthuis RJ. Reactive species-induced microvascular dysfunction in ischemia/reperfusion. Free Radical Biology & Medicine. PMID 30849489 DOI: 10.1016/j.freeradbiomed.2019.02.031   
2019 Yu M, Peng Z, Liao Y, Wang L, Li D, Qin C, Hu J, Wang Z, Cai M, Cai Q, Zhou F, Shi S, Yang W. Deoxynivalenol-induced Oxidative Stress and Nrf2 Translocation in maternal Liver on Gestation Day 12.5 d and 18.5 d. Toxicon : Official Journal of the International Society On Toxinology. PMID 30826469 DOI: 10.1016/j.toxicon.2019.02.018   
2019 Jung HL, Yang SY, Pyo MC, Hong CO, Nam MH, Lee JW, Lee KW. Protective effects of chebulic acid from Retz. against -BHP-induced oxidative stress by modulations of Nrf2 and its related enzymes in HepG2 cells. Food Science and Biotechnology. 28: 555-562. PMID 30956868 DOI: 10.1007/s10068-018-0477-z   
2019 Emami Z, Mesbah Namin A, Kojuri J, Mashayekhi Jalali F, Rasti M. Expression and Activity of Platelet Endothelial Nitric Oxide Synthase Are Decreased in Patients with Coronary Thrombosis and Stenosis. Avicenna Journal of Medical Biotechnology. 11: 88-93. PMID 30800248   
2019 Chowdhury S, Ghosh S, Das AK, Sil PC. Ferulic Acid Protects Hyperglycemia-Induced Kidney Damage by Regulating Oxidative Insult, Inflammation and Autophagy. Frontiers in Pharmacology. 10: 27. PMID 30804780 DOI: 10.3389/fphar.2019.00027   
2019 Ruiz-Medina BE, Lerma D, Hwang M, Ross JA, Skouta R, Aguilera RJ, Kirken RA, Varela-Ramirez A, Robles-Escajeda E. Green barley mitigates cytotoxicity in human lymphocytes undergoing aggressive oxidative stress, via activation of both the Lyn/PI3K/Akt and MAPK/ERK pathways. Scientific Reports. 9: 6005. PMID 30979953 DOI: 10.1038/s41598-019-42228-4   
2019 Ren K, Su H, Lv LJ, Yi LT, Gong X, Dang LS, Zhang RF, Li MH. Effects of Four Compounds from (Michx.) Hulten on Hydrogen Peroxide-Induced Injury in H9c2 Cells. Biomed Research International. 2019: 2692970. PMID 30800665 DOI: 10.1155/2019/2692970   
2019 Cigliano L, Spagnuolo MS, Napolitano G, Iannotta L, Fasciolo G, Barone D, Venditti P. 24S-hydroxycholesterol affects redox homeostasis in human glial U-87 MG cells. Molecular and Cellular Endocrinology. PMID 30802527 DOI: 10.1016/j.mce.2019.02.013   
2019 Gupta P, Singh A, Tiwari S, Mishra A, Maurya R, Singh S. Ulmosides A: Flavonoid 6-C-glycosides from Ulmus wallichiana attenuates lipopolysacchride induced oxidative stress, apoptosis and neuronal death. Neurotoxicology. PMID 30857974 DOI: 10.1016/j.neuro.2019.02.017   
2019 Brassington K, Selemidis S, Bozinovski S, Vlahos R. New frontiers in the treatment of comorbid cardiovascular disease in chronic obstructive pulmonary disease. Clinical Science (London, England : 1979). 133: 885-904. PMID 30979844 DOI: 10.1042/CS20180316   
2019 Zhong J, Xie J, Xiao J, Li D, Xu B, Wang X, Wen H, Zhou Z, Cheng Y, Xu J, Wang H. Inhibition of PDE4 by FCPR16 induces AMPK-dependent autophagy and confers neuroprotection in SH-SY5Y cells and neurons exposed to MPP-induced oxidative insult. Free Radical Biology & Medicine. PMID 30818055 DOI: 10.1016/j.freeradbiomed.2019.02.027   
2019 Dobi A, Bravo SB, Veeren B, Paradela-Dobarro B, Álvarez E, Meilhac O, Viranaicken W, Baret P, Devin A, Rondeau P. Advanced glycation end-products disrupt human endothelial cells redox homeostasis: new insights into reactive oxygen species production. Free Radical Research. 1-20. PMID 30821539 DOI: 10.1080/10715762.2018.1529866   
2019 de Groot LES, Sabogal Piñeros YS, Bal SM, van de Pol MA, Hamann J, Sterk PJ, Kulik W, Lutter R. Do eosinophils contribute to oxidative stress in mild asthma? Clinical and Experimental Allergy : Journal of the British Society For Allergy and Clinical Immunology. PMID 30891863 DOI: 10.1111/cea.13389   
2019 Zheng DH, Han ZQ, Wang XX, Ma D, Zhang J. Erythropoietin attenuates high glucose-induced oxidative stress and inhibition of osteogenic differentiation in periodontal ligament stem cell (PDLSCs). Chemico-Biological Interactions. PMID 30894315 DOI: 10.1016/j.cbi.2019.03.007   
2019 Cheng FR, Cui HX, Fang JL, Yuan K, Guo Y. Ameliorative Effect and Mechanism of the Purified Anthraquinone-Glycoside Preparation from L. on Type 2 Diabetes Mellitus. Molecules (Basel, Switzerland). 24. PMID 31013790 DOI: 10.3390/molecules24081454   
2019 Feng SQ, Zong SY, Liu JX, Chen Y, Xu R, Yin X, Zhao R, Li Y, Luo TT. VEGF antagonism attenuates cerebral ischemia/reperfusion-induced injury via inhibiting endoplasmic reticulum stress-mediated apoptosis. Biological & Pharmaceutical Bulletin. PMID 30828041 DOI: 10.1248/bpb.b18-00628   
2019 Park C, Cha HJ, Hong SH, Kim GY, Kim S, Kim HS, Kim BW, Jeon YJ, Choi YH. Protective Effect of Phloroglucinol on Oxidative Stress-Induced DNA Damage and Apoptosis through Activation of the Nrf2/HO-1 Signaling Pathway in HaCaT Human Keratinocytes. Marine Drugs. 17. PMID 31013932 DOI: 10.3390/md17040225   
2019 Arbeeny C, Ling H, Smith MM, O'Brien S, Wawersik S, Ledbetter SR, McAlexander MA, Willette R, Jorkasky D. CXA-10, a Nitrated Fatty Acid, is Renoprotective in Deoxycorticosterone Acetate-Salt Nephropathy. The Journal of Pharmacology and Experimental Therapeutics. PMID 30894457 DOI: 10.1124/jpet.118.254755   
2019 Feng X, Guan W, Zhao Y, Wang C, Song M, Yao Y, Yang T, Fan H. Dexmedetomidine ameliorates lipopolysaccharide-induced acute kidney injury in rats by inhibiting inflammation and oxidative stress via the GSK-3β/Nrf2 signaling pathway. Journal of Cellular Physiology. PMID 30919976 DOI: 10.1002/jcp.28539   
2019 Wang MJ, Peng XY, Lian ZQ, Zhu HB. The cordycepin derivative IMM-H007 improves endothelial dysfunction by suppressing vascular inflammation and promoting AMPK-dependent eNOS activation in high-fat diet-fed ApoE knockout mice. European Journal of Pharmacology. PMID 30826323 DOI: 10.1016/j.ejphar.2019.02.045   
2019 Chen S, Ma J, Zhu H, Deng S, Gu M, Qu S. Hydroxysafflor yellow A attenuates high glucose-induced human umbilical vein endothelial cell dysfunction. Human & Experimental Toxicology. 960327119831065. PMID 30873871 DOI: 10.1177/0960327119831065   
2019 Zhou W, Liang X, Zhang Y, Li K, Jin B, Lu L, Jin C, Lin X. Reduced nitrogen supply enhances the cellular antioxidant potential of phenolic extracts through the alteration of phenolic composition in lettuce (Lactuca sativa L.). Journal of the Science of Food and Agriculture. PMID 30932195 DOI: 10.1002/jsfa.9721