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Daniel Knutson - Publications

Affiliations: 
2020 Department of Chemistry and Biochemistry University of Wisconsin-Milwaukee, Milwaukee, WI 
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31 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Mitrović JR, Bjelošević Žiberna M, Vukadinović A, Knutson DE, Sharmin D, Kremenović A, Ahlin Grabnar P, Planinšek O, Lunter D, Cook JM, Savić MM, Savić SD. Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 189: 106557. PMID 37544333 DOI: 10.1016/j.ejps.2023.106557  0.336
2023 Huang YH, Lee MT, Hsueh HY, Knutson DE, Cook J, Mihovilovic MD, Sieghart W, Chiou LC. Cerebellar α6GABA Receptors as a Therapeutic Target for Essential Tremor: Proof-of-Concept Study with Ethanol and Pyrazoloquinolinones. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 36696034 DOI: 10.1007/s13311-023-01342-y  0.414
2023 Mitrović JR, Divović-Matović B, Knutson DE, Petković M, Djorović D, Randjelović DV, Dobričić VD, Đoković JB, Lunter DJ, Cook JM, Savić MM, Savić SD. High amount of lecithin facilitates oral delivery of a poorly soluble pyrazoloquinolinone ligand formulated in lipid nanoparticles: Physicochemical, structural and pharmacokinetic performances. International Journal of Pharmaceutics. 633: 122613. PMID 36657554 DOI: 10.1016/j.ijpharm.2023.122613  0.35
2022 Lee MT, Mouri A, Kubota H, Lee HJ, Chang MH, Wu CY, Knutson DE, Mihovilovic M, Cook J, Sieghart W, Nabeshima T, Chiou LC. Targeting α6GABA receptors as a novel therapy for schizophrenia: A proof-of-concept preclinical study using various animal models. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 150: 113022. PMID 35483195 DOI: 10.1016/j.biopha.2022.113022  0.425
2022 Witkin JM, Lippa A, Smith JL, Jin X, Ping X, Biggerstaff A, Kivell BM, Knutson DE, Sharmin D, Pandey KP, Mian MY, Cook JM, Cerne R. The imidazodiazepine, KRM-II-81: An example of a newly emerging generation of GABAkines for neurological and psychiatric disorders. Pharmacology, Biochemistry, and Behavior. 213: 173321. PMID 35041859 DOI: 10.1016/j.pbb.2021.173321  0.517
2021 Roni MSR, Zahn NM, Mikulsky BN, Webb DA, Mian MY, Knutson DE, Guthrie ML, Cook JM, Stafford DC, Arnold LA. Identification and Quantification of MIDD0301 metabolites. Current Drug Metabolism. PMID 34856893 DOI: 10.2174/1389200222666211202093841  0.357
2021 Santrač A, Batinić B, Stamenić TT, Aranđelović J, Sharmin D, Knutson DE, Cook JM, Savić MM. Positive modulation of α5GABAA receptors leads to dichotomous effects in rats on memory pattern and GABRA5 expression in prefrontal cortex and hippocampus. Behavioural Brain Research. 113578. PMID 34508769 DOI: 10.1016/j.bbr.2021.113578  0.36
2021 Duke AN, Tiruveedhula VVNPB, Sharmin D, Knutson DE, Cook JM, Platt DM, Rowlett JK. Tolerance and dependence following chronic alprazolam treatment in rhesus monkeys: Role of GABA receptor subtypes. Drug and Alcohol Dependence. 228: 108985. PMID 34500240 DOI: 10.1016/j.drugalcdep.2021.108985  0.525
2021 Mitrović JR, Divović-Matović B, Knutson DE, Đoković JB, Kremenović A, Dobričić VD, Randjelović DV, Pantelić I, Cook JM, Savić MM, Savić SD. Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach. Pharmaceutics. 13. PMID 34452149 DOI: 10.3390/pharmaceutics13081188  0.366
2021 Cadeddu R, Knutson DE, Mosher LJ, Loizou S, Odeh K, Fisher JL, Cook JM, Bortolato M. The α6 GABA Receptor Positive Allosteric Modulator DK-I-56-1 Reduces Tic-Related Behaviors in Mouse Models of Tourette Syndrome. Biomolecules. 11. PMID 33525455 DOI: 10.3390/biom11020175  0.56
2021 Fee C, Prevot TD, Misquitta K, Knutson DE, Li G, Mondal P, Cook JM, Banasr M, Sibille E. Behavioral deficits induced by somatostatin-positive GABA neuron silencing are rescued by alpha 5 GABA-A receptor potentiation. The International Journal of Neuropsychopharmacology. PMID 33438026 DOI: 10.1093/ijnp/pyab002  0.727
2021 Prevot T, Bernardo A, Lee P, Marcotte M, Knutson D, Sharmin D, Mian Y, Cook J, Sibille E. Positive Allosteric Modulation at α5-GABAA Receptor Reverses Cognitive Dysfunctions and Neuronal Atrophy in Mouse Model of Chronic Stress Biological Psychiatry. 89: S213-S214. DOI: 10.1016/j.biopsych.2021.02.540  0.33
2020 Pandey KP, Khan ZA, Golani LK, Mondal P, Mian Y, Rashid F, Tiruveedhula VVNPB, Knutson DE, Sharmin D, Ahmed T, Rezvanian S, Zahn NM, Arnold LA, Witkin JM, Cook JM. Design, synthesis and characterization of novel gamma‑aminobutyric acid type A receptor ligands. Arkivoc : Free Online Journal of Organic Chemistry. 2020: 242-256. PMID 33642954 DOI: 10.24820/ark.5550190.p011.398  0.582
2020 Zahn NM, Mikulsky BN, Roni MSR, Yocum GT, Mian MY, Knutson DE, Cook JM, Emala CW, Stafford DC, Arnold LA. Nebulized MIDD0301 Reduces Airway Hyperresponsiveness in Moderate and Severe Murine Asthma Models. Acs Pharmacology & Translational Science. 3: 1381-1390. PMID 33344908 DOI: 10.1021/acsptsci.0c00180  0.388
2020 Tzeng HR, Lee MT, Fan PC, Knutson DE, Lai TH, Sieghart W, Cook J, Chiou LC. α6GABA Receptor Positive Modulators Alleviate Migraine-like Grimaces in Mice via Compensating GABAergic Deficits in Trigeminal Ganglia. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 33111258 DOI: 10.1007/s13311-020-00951-1  0.537
2020 Prevot TD, Sumitomo A, Tomoda T, Knutson DE, Li G, Mondal P, Banasr M, Cook JM, Sibille E. Reversal of Age-Related Neuronal Atrophy by α5-GABAA Receptor Positive Allosteric Modulation. Cerebral Cortex (New York, N.Y. : 1991). PMID 33068001 DOI: 10.1093/cercor/bhaa310  0.705
2020 Knutson DE, Roni R, Mian Y, Cook JM, Stafford DC, Arnold LA. Improved scale-up synthesis and purification of clinical asthma candidate MIDD0301. Organic Process Research & Development. 24: 1467-1476. PMID 32952391 DOI: 10.1021/Acs.Oprd.0C00200  0.411
2020 Knutson DE, Smith JL, Ping X, Jin X, Golani LK, Li G, Tiruveedhula VVNPB, Rashid F, Mian MY, Jahan R, Sharmin D, Cerne R, Cook JM, Witkin JM. The Imidazodiazepine Anticonvulsant, KRM-II-81, Produces Novel, Non-diazepam-like Antiseizure Effects. Acs Chemical Neuroscience. PMID 32786313 DOI: 10.1021/Acschemneuro.0C00295  0.726
2020 Biggerstaff A, Kivell B, Smith JL, Mian MY, Golani LK, Rashid F, Sharmin D, Knutson DE, Cerne R, Cook JM, Witkin JM. The α2,3-selective potentiators of GABA receptors, KRM-II-81 and MP-III-80, produce anxiolytic-like effects, and block chemotherapy-induced hyperalgesia, in mice without tolerance development. Pharmacology, Biochemistry, and Behavior. 172996. PMID 32668266 DOI: 10.1016/J.Pbb.2020.172996  0.506
2020 Mitrović JR, Divović B, Knutson DE, Đoković JB, Vulić PJ, Randjelović DV, Dobričić VD, Čalija BR, Cook JM, Savić MM, Savić SD. Nanocrystal dispersion of DK-I-56-1, a poorly soluble pyrazoloquinolinone positive modulator of α6 GABA receptors: formulation approach toward improved in vivo performance. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 105432. PMID 32565331 DOI: 10.1016/J.Ejps.2020.105432  0.467
2020 Roni MSR, Li G, Mikulsky BN, Knutson DE, Mian MY, Zahn NM, Cook JM, Stafford DC, Arnold LA. The effects of pH on the structure and bioavailability of imidazobenzodiazepine-3-carboxylate MIDD0301. Molecular Pharmaceutics. PMID 32069056 DOI: 10.1021/Acs.Molpharmaceut.9B01210  0.619
2020 Prevot T, Li G, Knutson D, Mondal P, Mian Y, Guilloux J, Mendez-David I, David D, Cook J, Sibille E. Improved Cognitive Functions and Neurotrophic Effects of a Novel Molecule Enhancing α5-GABA-A Receptor Function in Adult or Aged Mice Biological Psychiatry. 87: S404. DOI: 10.1016/J.Biopsych.2020.02.1032  0.728
2019 Prevot TD, Li G, Vidojevic A, Misquitta KA, Fee C, Santrac A, Knutson DE, Stephen MR, Kodali R, Zahn NM, Arnold LA, Scholze P, Fisher JL, Marković BD, Banasr M, et al. Novel Benzodiazepine-Like Ligands with Various Anxiolytic, Antidepressant, or Pro-Cognitive Profiles. Molecular Neuropsychiatry. 5: 84-97. PMID 31192221 DOI: 10.1159/000496086  0.734
2019 Vasović D, Divović B, Treven M, Knutson DE, Steudle F, Scholze P, Obradović A, Fabjan J, Brković B, Sieghart W, Ernst M, Cook JM, Savić MM. Trigeminal neuropathic pain development and maintenance in rats are suppressed by a positive modulator of α6 GABA receptors. European Journal of Pain (London, England). PMID 30633839 DOI: 10.1002/Ejp.1365  0.562
2019 Divovic Matovic B, Mitrovic J, Knutson D, Batinic B, Savic S, Cook J, Savic M. P.463 Nanosuspension formulation of DK-I-56-1, a deuterated ligand functionally selective for the α6 GABAA receptors, induces hyperlocomotion in mice European Neuropsychopharmacology. 29: S327-S328. DOI: 10.1016/j.euroneuro.2019.09.474  0.347
2019 Prevot T, Li G, Misquitta K, Fee C, Knutson D, Stephen MR, Kodali R, Zahn N, Arnold LA, Banasr M, Cook J, Sibille E. T117. Pro-Cognitive Properties of a Novel GABA-A Receptor Positive Modulator in Animal Models of Depression and Aging Biological Psychiatry. 85: S174. DOI: 10.1016/J.Biopsych.2019.03.440  0.707
2018 Neumann E, Rudolph U, Knutson DE, Li G, Cook JM, Hentschke H, Antkowiak B, Drexler B. Zolpidem Activation of Alpha 1-Containing GABA Receptors Selectively Inhibits High Frequency Action Potential Firing of Cortical Neurons. Frontiers in Pharmacology. 9: 1523. PMID 30687091 DOI: 10.3389/Fphar.2018.01523  0.722
2018 Fan PC, Lai TH, Hor CC, Lee MT, Huang P, Sieghart W, Ernst M, Knutson DE, Cook J, Chiou LC. The α6 subunit-containing GABA receptor: A novel drug target for inhibition of trigeminal activation. Neuropharmacology. PMID 30016665 DOI: 10.1016/J.Neuropharm.2018.07.017  0.505
2018 Chiou LC, Lee HJ, Ernst M, Huang WJ, Chou JF, Chen HL, Mouri A, Chen LC, Treven M, Mamiya T, Fan PC, Knutson DE, Witzigmann C, Cook J, Sieghart W, et al. Cerebellar α6 subunit-containing GABAreceptors: A novel therapeutic target for disrupted prepulse inhibition in neuropsychiatric disorders. British Journal of Pharmacology. PMID 29518821 DOI: 10.1111/Bph.14198  0.516
2018 Knutson DE, Kodali R, Divovic B, Treven M, Stephen MR, Zahn NM, Dobričić V, Huber AT, Meirelles MA, Verma RS, Wimmer L, Witzigmann C, Arnold LA, Chiou LC, Ernst M, et al. Design and Synthesis of Novel Deuterated Ligands Functionally Selective for the γ-Aminobutyric Acid Type A Receptor (GABAR) α6 Subtype with Improved Metabolic Stability and Enhanced Bioavailability. Journal of Medicinal Chemistry. PMID 29481759 DOI: 10.1021/Acs.Jmedchem.7B01664  0.684
2018 Prevot T, Li G, Vidojevic A, Santrac A, Misquitta K, Hu X, Knutson D, Arnold L, Fisher J, Banasr M, Cook J, Savic M, Sibille E. S162. Antidepressant and Pro-Cognitive Effects of a Novel Series of GABA-A Receptor Positive Allosteric Modulators With α5 Subunit Efficacy Properties Biological Psychiatry. 83: S411. DOI: 10.1016/J.Biopsych.2018.02.1054  0.743
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