| Year |
Citation |
Score |
| 2023 |
Kahsai AW, Shah KS, Shim PJ, Lee MA, Shreiber BN, Schwalb AM, Zhang X, Kwon HY, Huang LY, Soderblom EJ, Ahn S, Lefkowitz RJ. Signal transduction at GPCRs: Allosteric activation of the ERK MAPK by β-arrestin. Proceedings of the National Academy of Sciences of the United States of America. 120: e2303794120. PMID 37844230 DOI: 10.1073/pnas.2303794120 |
0.734 |
|
| 2022 |
Asher WB, Terry DS, Gregorio GGA, Kahsai AW, Borgia A, Xie B, Modak A, Zhu Y, Jang W, Govindaraju A, Huang LY, Inoue A, Lambert NA, Gurevich VV, Shi L, et al. GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision. Cell. PMID 35483373 DOI: 10.1016/j.cell.2022.03.042 |
0.727 |
|
| 2021 |
Zang Y, Kahsai AW, Pakharukova N, Huang LY, Lefkowitz RJ. The GPCR-β-arrestin complex allosterically activates C-Raf by binding its amino-terminus. The Journal of Biological Chemistry. 101369. PMID 34757127 DOI: 10.1016/j.jbc.2021.101369 |
0.812 |
|
| 2019 |
Nguyen AH, Thomsen ARB, Cahill TJ, Huang R, Huang LY, Marcink T, Clarke OB, Heissel S, Masoudi A, Ben-Hail D, Samaan F, Dandey VP, Tan YZ, Hong C, Mahoney JP, et al. Structure of an endosomal signaling GPCR-G protein-β-arrestin megacomplex. Nature Structural & Molecular Biology. PMID 31740855 DOI: 10.1038/S41594-019-0330-Y |
0.824 |
|
| 2019 |
Liu X, Masoudi A, Kahsai AW, Huang LY, Pani B, Staus DP, Shim PJ, Hirata K, Simhal RK, Schwalb AM, Rambarat PK, Ahn S, Lefkowitz RJ, Kobilka B. Mechanism of βAR regulation by an intracellular positive allosteric modulator. Science (New York, N.Y.). 364: 1283-1287. PMID 31249059 DOI: 10.1126/science.aaw8981 |
0.8 |
|
| 2019 |
Liu X, Masoudi A, Kahsai AW, Huang L, Pani B, Staus DP, Shim PJ, Hirata K, Simhal RK, Schwalb AM, Rambarat PK, Ahn S, Lefkowitz RJ, Kobilka B. Mechanism of beta2AR regulation by an intracellular positive allosteric modulator. Science. 364: 1283-1287. DOI: 10.2210/Pdb6N48/Pdb |
0.813 |
|
| 2018 |
Ahn S, Pani B, Kahsai AW, Olsen EK, Husemoen G, Vestrgaard M, Jin L, Zhao S, Wingler LM, Rambarat PK, Simhal RK, Xu TT, Sun LD, Shim PJ, Staus DP, ... Huang LY, et al. Small Molecule Positive Allosteric Modulators of the β-Adrenoceptor Isolated from DNA Encoded Libraries. Molecular Pharmacology. PMID 29769246 DOI: 10.1124/Mol.118.111948 |
0.779 |
|
| 2017 |
Rein LA, Wisler JW, Kim J, Theriot B, Huang L, Price T, Yang H, Chen M, Chen W, Sipkins D, Fedoriw Y, Walker JK, Premont RT, Lefkowitz RJ. β-Arrestin2 mediates progression of murine primary myelofibrosis. Jci Insight. 2. PMID 29263312 DOI: 10.1172/Jci.Insight.98094 |
0.7 |
|
| 2017 |
Cahill TJ, Thomsen AR, Tarrasch JT, Plouffe B, Nguyen AH, Yang F, Huang LY, Kahsai AW, Bassoni DL, Gavino BJ, Lamerdin JE, Triest S, Shukla AK, Berger B, Little J, et al. Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 28223524 DOI: 10.1073/Pnas.1701529114 |
0.842 |
|
| 2016 |
Thomsen AR, Plouffe B, Cahill TJ, Shukla AK, Tarrasch JT, Dosey AM, Kahsai AW, Strachan RT, Pani B, Mahoney JP, Huang L, Breton B, Heydenreich FM, Sunahara RK, Skiniotis G, et al. GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling. Cell. PMID 27499021 DOI: 10.1016/J.Cell.2016.07.004 |
0.812 |
|
| 2015 |
Rein LA, Wisler JW, Theriot BS, Huang L, Premont RT, Lefkowitz RJ. β-arrestin2 Is Necessary for Development of MPLW515L Mutant Primary Myelofibrosis Blood. 126: 486-486. DOI: 10.1182/Blood.V126.23.486.486 |
0.631 |
|
| 2014 |
Shukla AK, Westfield GH, Xiao K, Reis RI, Huang LY, Tripathi-Shukla P, Qian J, Li S, Blanc A, Oleskie AN, Dosey AM, Su M, Liang CR, Gu LL, Shan JM, et al. Visualization of arrestin recruitment by a G-protein-coupled receptor. Nature. 512: 218-22. PMID 25043026 DOI: 10.1038/Nature13430 |
0.709 |
|
| 2013 |
Shukla AK, Manglik A, Kruse AC, Xiao K, Reis RI, Tseng WC, Staus DP, Hilger D, Uysal S, Huang LY, Paduch M, Tripathi-Shukla P, Koide A, Koide S, Weis WI, et al. Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Nature. 497: 137-41. PMID 23604254 DOI: 10.1038/Nature12120 |
0.852 |
|
| 2011 |
Umanah GK, Huang LY, Maccarone JM, Naider F, Becker JM. Changes in conformation at the cytoplasmic ends of the fifth and sixth transmembrane helices of a yeast G protein-coupled receptor in response to ligand binding. Biochemistry. 50: 6841-54. PMID 21728340 DOI: 10.1021/Bi200254H |
0.439 |
|
| 2010 |
Umanah GK, Huang L, Ding FX, Arshava B, Farley AR, Link AJ, Naider F, Becker JM. Identification of residue-to-residue contact between a peptide ligand and its G protein-coupled receptor using periodate-mediated dihydroxyphenylalanine cross-linking and mass spectrometry. The Journal of Biological Chemistry. 285: 39425-36. PMID 20923758 DOI: 10.1074/Jbc.M110.149500 |
0.413 |
|
| 2009 |
Umanah G, Huang LY, Schultz PG, Naider F, Becker JM. Incorporation of the unnatural amino acid p-benzoyl-L-phenylalanine (Bpa) into a G protein-coupled receptor in its native context. Advances in Experimental Medicine and Biology. 611: 333-5. PMID 19400216 DOI: 10.1007/978-0-387-73657-0_149 |
0.383 |
|
| 2008 |
Huang LY, Umanah G, Hauser M, Son C, Arshava B, Naider F, Becker JM. Unnatural amino acid replacement in a yeast G protein-coupled receptor in its native environment. Biochemistry. 47: 5638-48. PMID 18419133 DOI: 10.1021/Bi701866E |
0.381 |
|
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