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Huimin Zhao, Ph.D - Publications

Affiliations: 
Chemical and Biomolecular Engineering University of Illinois, Urbana-Champaign, Urbana-Champaign, IL 
Area:
Directed evolution, metabolic engineering, natural product, gene therapy, synthetic biology
Website:
http://scs.illinois.edu/~zhaogrp/
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309 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2025 Dong J, Croslow SW, Lane ST, Castro DC, Blanford J, Zhou S, Park K, Burgess S, Root M, Cahoon E, Shanklin J, Sweedler JV, Zhao H, Hudson ME. Enhancing lipid production in plant cells through automated high-throughput genome editing and phenotyping. The Plant Cell. PMID 39899469 DOI: 10.1093/plcell/koaf026  0.406
2024 Ma K, Xue B, Chu R, Zheng Y, Sharma S, Jiang L, Hu M, Xie Y, Hu Y, Tao T, Zhou Y, Liu D, Li Z, Yang Q, Chen Y, ... ... Zhao H, et al. A Widespread Radical-Mediated Glycolysis Pathway. Journal of the American Chemical Society. PMID 39283600 DOI: 10.1021/jacs.4c07718  0.637
2024 Klumbys E, Xu W, Koduru L, Heng E, Wei Y, Wong FT, Zhao H, Ang EL. Discovery, characterization, and engineering of an advantageous Streptomyces host for heterologous expression of natural product biosynthetic gene clusters. Microbial Cell Factories. 23: 149. PMID 38790014 DOI: 10.1186/s12934-024-02416-y  0.622
2024 Peh G, Tay T, Tan LL, Tiong E, Bi J, Goh YL, Ye S, Lin F, Tan CJX, Tan YZ, Wong J, Zhao H, Wong FT, Ang EL, Lim YH. Site-selective chlorination of pyrrolic heterocycles by flavin dependent enzyme PrnC. Communications Chemistry. 7: 7. PMID 38182798 DOI: 10.1038/s42004-023-01083-1  0.619
2023 Peh G, Gunawan GA, Tay T, Tiong E, Tan LL, Jiang S, Goh YL, Ye S, Wong J, Brown CJ, Zhao H, Ang EL, Wong FT, Lim YH. Further Characterization of Fungal Halogenase RadH and Its Homologs. Biomolecules. 13. PMID 37509117 DOI: 10.3390/biom13071081  0.608
2023 Zhou S, Fatma Z, Xue P, Mishra S, Cao M, Zhao H, Sweedler JV. Mass Spectrometry-Based High-Throughput Quantification of Bioproducts in Liquid Culture. Analytical Chemistry. PMID 36790390 DOI: 10.1021/acs.analchem.2c04845  0.371
2023 Cheong CB, Peh G, Wei Y, T R, Ang EL, Zhao H, Zhang C, Lim YH. A Spirobicyclo[3.1.0]Terpene from the Investigation of Sesquiterpene Synthases from . Acs Chemical Biology. PMID 36594743 DOI: 10.1021/acschembio.2c00760  0.645
2022 Cabera A, Edelstein HI, Glykofrydis F, Love KS, Palacios S, Tycko J, Zhang M, Lensch S, Shields CE, Livingston M, Weiss R, Zhao H, Haynes KA, Morsut L, Chen YY, et al. The sound of silence: Transgene silencing in mammalian cell engineering. Cell Systems. 13: 950-973. PMID 36549273 DOI: 10.1016/j.cels.2022.11.005  0.317
2022 Mishra S, Wang Z, Volk MJ, Zhao H. Design and application of a kinetic model of lipid metabolism in Saccharomyces cerevisiae. Metabolic Engineering. 75: 12-18. PMID 36371031 DOI: 10.1016/j.ymben.2022.11.003  0.407
2022 Ayikpoe RS, Shi C, Battiste AJ, Eslami SM, Ramesh S, Simon MA, Bothwell IR, Lee H, Rice AJ, Ren H, Tian Q, Harris LA, Sarksian R, Zhu L, Frerk AM, ... ... Zhao H, et al. A scalable platform to discover antimicrobials of ribosomal origin. Nature Communications. 13: 6135. PMID 36253467 DOI: 10.1038/s41467-022-33890-w  0.454
2022 Zhao F, Wei Y, Wang X, Zhou Y, Tong Y, Ang EL, Liu S, Zhao H, Zhang Y. Enzymatic Synthesis of the Unnatural Nucleotide 2'-Deoxyisoguanosine 5'-Monophosphate. Chembiochem : a European Journal of Chemical Biology. PMID 35959532 DOI: 10.1002/cbic.202200295  0.61
2022 Lee CJ, Qiu TA, Hong Z, Zhang Z, Min Y, Zhang L, Dai L, Zhao H, Si T, Sweedler JV. Profiling of d-alanine production by the microbial isolates of rat gut microbiota. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 36: e22446. PMID 35816159 DOI: 10.1096/fj.202101595R  0.54
2022 Duan Y, Wei Y, Xing M, Liu J, Jiang L, Lu Q, Liu X, Liu Y, Ang EL, Liao RZ, Yuchi Z, Zhao H, Zhang Y. Anaerobic Hydroxyproline Degradation Involving C-N Cleavage by a Glycyl Radical Enzyme. Journal of the American Chemical Society. PMID 35611954 DOI: 10.1021/jacs.2c01673  0.629
2022 Liu Y, Wei Y, Teh TM, Liu D, Zhou Y, Zhao S, Ang EL, Zhao H, Zhang Y. Identification and Characterization of the Biosynthetic Pathway of the Sulfonolipid Capnine. Biochemistry. PMID 35414181 DOI: 10.1021/acs.biochem.2c00102  0.61
2022 Liang J, Zhang H, Tan YL, Zhao H, Ang EL. Directed Evolution of Replication-Competent Double-Stranded DNA Bacteriophage toward New Host Specificity. Acs Synthetic Biology. 11: 634-643. PMID 35090114 DOI: 10.1021/acssynbio.1c00319  0.612
2021 Dong C, Shi Z, Huang L, Zhao H, Xu Z, Lian J. Cloning and Characterization of a Panel of Mitochondrial Targeting Sequences for Compartmentalization Engineering in Saccharomyces cerevisiae. Biotechnology and Bioengineering. PMID 34273106 DOI: 10.1002/bit.27896  0.625
2021 Zhou Y, Xu X, Wei Y, Cheng Y, Guo Y, Khudyakov I, Liu F, He P, Song Z, Li Z, Gao Y, Ang EL, Zhao H, Zhang Y, Zhao S. A widespread pathway for substitution of adenine by diaminopurine in phage genomes. Science (New York, N.Y.). 372: 512-516. PMID 33926954 DOI: 10.1126/science.abe4882  0.61
2021 Choe K, Xue P, Zhao H, Sweedler JV. macroMS: Image-Guided Analysis of Random Objects by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry. Journal of the American Society For Mass Spectrometry. PMID 33822609 DOI: 10.1021/jasms.1c00013  0.339
2021 Dong C, Schultz C, Liu W, Lian J, Huang L, Xu Z, Zhao H. Identification of novel metabolic engineering targets for S-adenosyl-L-Methionine production in Saccharomyces cerevisiae via genome-scale engineering. Metabolic Engineering. PMID 33713797 DOI: 10.1016/j.ymben.2021.03.005  0.646
2021 Enghiad B, Huang C, Guo F, Jiang G, Wang B, Tabatabaei SK, Martin TA, Zhao H. Cas12a-assisted precise targeted cloning using in vivo Cre-lox recombination. Nature Communications. 12: 1171. PMID 33608525 DOI: 10.1038/s41467-021-21275-4  0.308
2021 Zhang M, Yang C, Tasan I, Zhao H. Expanding the Potential of Mammalian Genome Engineering Targeted DNA Integration. Acs Synthetic Biology. PMID 33596056 DOI: 10.1021/acssynbio.0c00576  0.302
2020 Liu Y, Wei Y, Zhou Y, Ang EL, Zhao H, Zhang Y. A transaldolase-dependent sulfoglycolysis pathway in Bacillus megaterium DSM 1804. Biochemical and Biophysical Research Communications. PMID 33036753 DOI: 10.1016/j.bbrc.2020.09.124  0.597
2020 Xue P, Si T, Zhao H. Optically guided mass spectrometry to screen microbial colonies for directed enzyme evolution. Methods in Enzymology. 644: 255-273. PMID 32943148 DOI: 10.1016/Bs.Mie.2020.04.054  0.578
2020 Tasan I, Su CJ, Enghiad B, Zhang M, Mishra S, Zhao H. Two-Color Imaging of Non-repetitive Endogenous Loci in Human Cells. Acs Synthetic Biology. PMID 32822529 DOI: 10.1021/Acssynbio.0C00295  0.371
2020 Cao M, Tran VG, Zhao H. Unlocking nature's biosynthetic potential by directed genome evolution. Current Opinion in Biotechnology. 66: 95-104. PMID 32721868 DOI: 10.1016/J.Copbio.2020.06.012  0.349
2020 Wang F, Wei Y, Lu Q, Ang EL, Zhao H, Zhang Y. A ferredoxin-dependent dihydropyrimidine dehydrogenase in Clostridium chromiireducens. Bioscience Reports. 40. PMID 32614053 DOI: 10.1042/Bsr20201642  0.641
2020 Liu J, Wei Y, Lin L, Teng L, Yin J, Lu Q, Chen J, Zheng Y, Li Y, Xu R, Zhai W, Liu Y, Liu Y, Cao P, Ang EL, ... Zhao H, et al. Two radical-dependent mechanisms for anaerobic degradation of the globally abundant organosulfur compound dihydroxypropanesulfonate. Proceedings of the National Academy of Sciences of the United States of America. PMID 32571930 DOI: 10.1073/Pnas.2003434117  0.654
2020 Xu W, Klumbys E, Ang EL, Zhao H. Emerging molecular biology tools and strategies for engineering natural product biosynthesis. Metabolic Engineering Communications. 10: e00108. PMID 32547925 DOI: 10.1016/J.Mec.2019.E00108  0.666
2020 Huang X, Wang B, Wang Y, Jiang G, Feng J, Zhao H. Photoenzymatic enantioselective intermolecular radical hydroalkylation. Nature. PMID 32512577 DOI: 10.1038/S41586-020-2406-6  0.377
2020 Ye S, Enghiad B, Zhao H, Takano E. Fine-tuning the regulation of Cas9 expression levels for efficient CRISPR-Cas9 mediated recombination in Streptomyces. Journal of Industrial Microbiology & Biotechnology. PMID 32367443 DOI: 10.1007/S10295-020-02277-5  0.322
2020 Ren H, Shi C, Bothwell IR, van der Donk WA, Zhao H. Discovery and Characterization of a Class IV Lanthipeptide with a Non-overlapping Ring Pattern. Acs Chemical Biology. PMID 32356655 DOI: 10.1021/Acschembio.0C00267  0.517
2020 Fatma Z, Schultz C, Zhao H. Recent Advances in Domesticating Non-model Microorganisms. Biotechnology Progress. e3008. PMID 32329213 DOI: 10.1002/Btpr.3008  0.326
2020 Xue P, Si T, Mishra S, Zhang L, Choe K, Sweedler JV, Zhao H. A Mass Spectrometry-based High-throughput Screening Method for Engineering Fatty Acid Synthases with Improved Production of Medium Chain Fatty Acids. Biotechnology and Bioengineering. PMID 32219854 DOI: 10.1002/Bit.27343  0.615
2020 Wang B, Guo F, Huang C, Zhao H. Unraveling the iterative type I polyketide synthases hidden in . Proceedings of the National Academy of Sciences of the United States of America. PMID 32217738 DOI: 10.1073/Pnas.1917664117  0.407
2020 Sun H, Zhao H, Ang EL. A new biosensor for stilbenes and a cannabinoid enabled by genome mining of a transcriptional regulator. Acs Synthetic Biology. PMID 32078771 DOI: 10.1021/Acssynbio.9B00443  0.668
2020 Wang B, Zhao H. Unleashing the power of energy storage: Engineering β-oxidation pathways for polyketide production. Synthetic and Systems Biotechnology. 5: 21-22. PMID 32042931 DOI: 10.1016/J.Synbio.2020.01.002  0.382
2020 Cao M, Fatma Z, Song X, Hsieh PH, Tran VG, Lyon WL, Sayadi M, Shao Z, Yoshikuni Y, Zhao H. A genetic toolbox for metabolic engineering of Issatchenkia orientalis. Metabolic Engineering. PMID 32007615 DOI: 10.1016/J.Ymben.2020.01.005  0.558
2020 Zhu D, Wei Y, Yin J, Liu D, Ang EL, Zhao H, Zhang Y. A pathway for degradation of uracil to acetyl coenzyme A in . Applied and Environmental Microbiology. PMID 31953335 DOI: 10.1128/Aem.02837-19  0.644
2020 Yu Y, Guo Y, Tian Q, Lan Y, Yeh H, Zhang M, Tasan I, Jain S, Zhao H. Publisher Correction: An efficient gene knock-in strategy using 5'-modified double-stranded DNA donors with short homology arms. Nature Chemical Biology. PMID 31942048 DOI: 10.1038/S41589-020-0470-8  0.356
2020 Yeo WL, Heng E, Tan LL, Lim YW, Ching KC, Tsai DJ, Jhang YW, Lauderdale TL, Shia KS, Zhao H, Ang EL, Zhang MM, Lim YH, Wong FT. Biosynthetic engineering of the antifungal, anti-MRSA auroramycin. Microbial Cell Factories. 19: 3. PMID 31906943 DOI: 10.1186/S12934-019-1274-Y  0.655
2020 Wang Y, Huang X, Hui J, Vo LT, Zhao H. Stereoconvergent Reduction of Activated Alkenes by a Nicotinamide Free Synergistic Photobiocatalytic System Acs Catalysis. 10: 9431-9437. DOI: 10.1021/Acscatal.0C02489  0.341
2019 Fasan R, Jennifer Kan SB, Zhao H. A Continuing Career in Biocatalysis: Frances H. Arnold. Acs Catalysis. 9: 9775-9788. PMID 32728486 DOI: 10.1021/Acscatal.9B02737  0.646
2019 Yu Y, Guo Y, Tian Q, Lan Y, Yeh H, Zhang M, Tasan I, Jain S, Zhao H. An efficient gene knock-in strategy using 5'-modified double-stranded DNA donors with short homology arms. Nature Chemical Biology. PMID 31873222 DOI: 10.1038/S41589-019-0432-1  0.388
2019 Cuculis L, Zhao C, Abil Z, Zhao H, Shukla D, Schroeder CM. Divalent cations promote TALE DNA-binding specificity. Nucleic Acids Research. PMID 31863586 DOI: 10.1093/Nar/Gkz1174  0.31
2019 Lian J, Schultz C, Cao M, HamediRad M, Zhao H. Multi-functional genome-wide CRISPR system for high throughput genotype-phenotype mapping. Nature Communications. 10: 5794. PMID 31857575 DOI: 10.1038/S41467-019-13621-4  0.632
2019 HamediRad M, Chao R, Weisberg S, Lian J, Sinha S, Zhao H. Towards a fully automated algorithm driven platform for biosystems design. Nature Communications. 10: 5150. PMID 31723141 DOI: 10.1038/S41467-019-13189-Z  0.606
2019 Dinh HV, Suthers PF, Chan SHJ, Shen Y, Xiao T, Deewan A, Jagtap SS, Zhao H, Rao CV, Rabinowitz JD, Maranas CD. A comprehensive genome-scale model for IFO0880 accounting for functional genomics and phenotypic data. Metabolic Engineering Communications. 9: e00101. PMID 31720216 DOI: 10.1016/J.Mec.2019.E00101  0.341
2019 Wei Y, Tan YL, Ang EL, Zhao H. Identification and Characterization of Citrus Peel  Uronic Acid Oxidase. Chembiochem : a European Journal of Chemical Biology. PMID 31587437 DOI: 10.1002/Cbic.201900546  0.627
2019 Yin J, Wei Y, Liu D, Hu Y, Lu Q, Ang EL, Zhao H, Zhang Y. An extended bacterial reductive pyrimidine degradation pathway that enables nitrogen release from β-alanine. The Journal of Biological Chemistry. PMID 31455636 DOI: 10.1074/Jbc.Ra119.010406  0.651
2019 Wen F, Smith MR, Zhao H. Construction and Screening of an Antigen-Derived Peptide Library Displayed on Yeast Cell Surface for CD4+ T Cell Epitope Identification. Methods in Molecular Biology (Clifton, N.J.). 2024: 213-234. PMID 31364052 DOI: 10.1007/978-1-4939-9597-4_13  0.395
2019 Xing M, Wei Y, Hua G, Li M, Nanjaraj Urs AN, Wang F, Hu Y, Zhai W, Liu Y, Ang EL, Zhao H, Zhang Y. A gene cluster for taurine sulfur assimilation in an anaerobic human gut bacterium. The Biochemical Journal. PMID 31350331 DOI: 10.1042/Bcj20190486  0.633
2019 Tong Y, Wei Y, Hu Y, Ang EL, Zhao H, Zhang Y. A pathway for isethionate dissimilation in . Applied and Environmental Microbiology. PMID 31126948 DOI: 10.1128/Aem.00793-19  0.651
2019 Zhou Y, Wei Y, Nanjaraj Urs AN, Lin L, Xu T, Hu Y, Ang EL, Zhao H, Yuchi Z, Zhang Y. Identification and characterization of a new sulfoacetaldehyde reductase from the human gut bacterium . Bioscience Reports. PMID 31123167 DOI: 10.1042/Bsr20190715  0.649
2019 Yeo WL, Heng E, Tan LL, Lim YW, Lim YH, Hoon S, Zhao H, Zhang MM, Wong FT. Characterization of Cas proteins for CRISPR-Cas editing in streptomycetes. Biotechnology and Bioengineering. PMID 31090220 DOI: 10.1002/Bit.27021  0.305
2019 Li M, Wei Y, Yin J, Lin L, Zhou Y, Hua G, Cao P, Ang EL, Zhao H, Yuchi Z, Zhang Y. Biochemical and structural investigation of taurine:2-oxoglutarate aminotransferase from . The Biochemical Journal. PMID 31088892 DOI: 10.1042/Bcj20190206  0.656
2019 Schultz JC, Cao M, Zhao H. Development of a CRISPR/Cas9 System for High Efficiency Multiplexed Gene Deletion in Rhodosporidium toruloides. Biotechnology and Bioengineering. PMID 31038202 DOI: 10.1002/Bit.27001  0.391
2019 HamediRad M, Weisberg S, Chao R, Lian J, Zhao H. Highly Efficient Single-pot Scar-less Golden Gate Assembly. Acs Synthetic Biology. PMID 31013062 DOI: 10.1021/Acssynbio.8B00480  0.606
2019 Xing M, Wei Y, Zhou Y, Zhang J, Lin L, Hu Y, Hua G, N Nanjaraj Urs A, Liu D, Wang F, Guo C, Tong Y, Li M, Liu Y, Ang EL, ... Zhao H, et al. Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria. Nature Communications. 10: 1609. PMID 30962433 DOI: 10.1038/S41467-019-09618-8  0.643
2019 Shi S, Liang Y, Ang EL, Zhao H. Delta Integration CRISPR-Cas (Di-CRISPR) in Saccharomyces cerevisiae. Methods in Molecular Biology (Clifton, N.J.). 1927: 73-91. PMID 30788786 DOI: 10.1007/978-1-4939-9142-6_6  0.628
2019 Zhou Y, Wei Y, Lin L, Xu T, Ang EL, Zhao H, Yuchi Z, Zhang Y. Biochemical and structural investigation of sulfoacetaldehyde reductase from . The Biochemical Journal. PMID 30718306 DOI: 10.1042/Bcj20190005  0.637
2019 Nguyen K, DeSieno MA, Bae B, Johannes TW, Cobb RE, Zhao H, Nair SK. Characterization of the flavin monooxygenase involved in biosynthesis of the antimalarial FR-900098. Organic & Biomolecular Chemistry. PMID 30681110 DOI: 10.1039/C8Ob02840K  0.781
2018 Wang B, Guo F, Dong SH, Zhao H. Activation of silent biosynthetic gene clusters using transcription factor decoys. Nature Chemical Biology. PMID 30598544 DOI: 10.1038/S41589-018-0187-0  0.355
2018 Liu D, Wei Y, Liu X, Zhou Y, Jiang L, Yin J, Wang F, Hu Y, Nanjaraj Urs AN, Liu Y, Ang EL, Zhao S, Zhao H, Zhang Y. Indoleacetate decarboxylase is a glycyl radical enzyme catalysing the formation of malodorant skatole. Nature Communications. 9: 4224. PMID 30310076 DOI: 10.1038/S41467-018-06627-X  0.652
2018 Si T, Tian Q, Min Y, Zhang L, Sweedler JV, van der Donk WA, Zhao H. Rapid structure-activity screening of lanthipeptide analogs via in-colony removal of leader peptides in Escherichia coli. Journal of the American Chemical Society. PMID 30183279 DOI: 10.1021/Jacs.8B05544  0.679
2018 Ren H, Biswas S, Ho S, van der Donk WA, Zhao H. Rapid Discovery of Glycocins through Pathway Refactoring in Escherichia coli. Acs Chemical Biology. PMID 30183259 DOI: 10.1021/Acschembio.8B00599  0.539
2018 Schultz C, Lian J, Zhao H. Metabolic Engineering of Saccharomyces cerevisiae Using a Trifunctional CRISPR/Cas System for Simultaneous Gene Activation, Interference, and Deletion. Methods in Enzymology. 608: 265-276. PMID 30173764 DOI: 10.1016/Bs.Mie.2018.04.010  0.666
2018 Litman ZC, Wang Y, Zhao H, Hartwig JF. Cooperative asymmetric reactions combining photocatalysis and enzymatic catalysis. Nature. 560: 355-359. PMID 30111790 DOI: 10.1038/S41586-018-0413-7  0.335
2018 Sun H, Zhao H, Ang EL. A coupled chlorinase-fluorinase system with a high efficiency of trans-halogenation and a shared substrate tolerance. Chemical Communications (Cambridge, England). PMID 30083673 DOI: 10.1039/C8Cc04436H  0.637
2018 Katz L, Chen YY, Gonzalez R, Peterson TC, Zhao H, Baltz RH. Synthetic biology advances and applications in the biotechnology industry: a perspective. Journal of Industrial Microbiology & Biotechnology. PMID 29915997 DOI: 10.1007/S10295-018-2056-Y  0.371
2018 Tasan I, Sustackova G, Zhang L, Kim J, Sivaguru M, HamediRad M, Wang Y, Genova J, Ma J, Belmont AS, Zhao H. CRISPR/Cas9-mediated knock-in of an optimized TetO repeat for live cell imaging of endogenous loci. Nucleic Acids Research. PMID 29912475 DOI: 10.1093/Nar/Gky501  0.306
2018 Zhao H, Lim YH, Wong FT, Yeo WL, Ching KC, Lim YW, Heng E, Chen S, Tsai DJ, Lauderdale TL, Shia KS, Ho YS, Hoon S, Ang EL, Zhang MM. Auroramycin, a potent antibiotic from Streptomyces roseosporus by CRISPR-Cas9 activation. Chembiochem : a European Journal of Chemical Biology. PMID 29799651 DOI: 10.1002/Cbic.201800266  0.625
2018 Bao Z, HamediRad M, Xue P, Xiao H, Tasan I, Chao R, Liang J, Zhao H. Genome-scale engineering of Saccharomyces cerevisiae with single-nucleotide precision. Nature Biotechnology. PMID 29734295 DOI: 10.1038/Nbt.4132  0.336
2018 Lian J, Mishra S, Zhao H. Recent Advances in Metabolic Engineering of Saccharomyces cerevisiae: New Tools and Their Applications. Metabolic Engineering. PMID 29702275 DOI: 10.1016/J.Ymben.2018.04.011  0.664
2018 Tapsin S, Sun M, Shen Y, Zhang H, Lim XN, Susanto TT, Yang SL, Zeng GS, Lee J, Lezhava A, Ang EL, Zhang LH, Wang Y, Zhao H, Nagarajan N, et al. Genome-wide identification of natural RNA aptamers in prokaryotes and eukaryotes. Nature Communications. 9: 1289. PMID 29599443 DOI: 10.1038/S41467-018-03675-1  0.598
2018 Lian J, Bao Z, Hu S, Zhao H. Engineered CRISPR/Cas9 System for Multiplex Genome Engineering of Polyploid Industrial Yeast Strains. Biotechnology and Bioengineering. PMID 29460422 DOI: 10.1002/Bit.26569  0.659
2018 HamediRad M, Lian J, Li H, Zhao H. RNAi Assisted Genome Evolution Unveils Yeast Mutants with Improved Xylose Utilization. Biotechnology and Bioengineering. PMID 29460286 DOI: 10.1002/Bit.26570  0.662
2018 Lian J, HamediRad M, Zhao H. Advancing Metabolic Engineering of Saccharomyces cerevisiae using the CRISPR/Cas System. Biotechnology Journal. PMID 29436783 DOI: 10.1002/Biot.201700601  0.66
2018 Wang Y, Ren H, Zhao H. Expanding the boundary of biocatalysis: design and optimization of in vitro tandem catalytic reactions for biochemical production. Critical Reviews in Biochemistry and Molecular Biology. 1-15. PMID 29411648 DOI: 10.1080/10409238.2018.1431201  0.386
2018 Limsakul P, Peng Q, Wu Y, Allen ME, Liang J, Remacle AG, Lopez T, Ge X, Kay BK, Zhao H, Strongin AY, Yang XL, Lu S, Wang Y. Directed Evolution to Engineer Monobody for FRET Biosensor Assembly and Imaging at Live-Cell Surface. Cell Chemical Biology. PMID 29396288 DOI: 10.1016/J.Chembiol.2018.01.002  0.311
2018 Shi S, Ang EL, Zhao H. In vivo biosensors: mechanisms, development, and applications. Journal of Industrial Microbiology & Biotechnology. PMID 29380152 DOI: 10.1007/S10295-018-2004-X  0.659
2018 Singh RK, Singh R, Sivakumar D, Kondaveeti S, Kim T, Li J, Sung BH, Cho BK, Kim DR, Kim SC, Kalia VC, Zhang YHPJ, Zhao H, Kang YC, Lee JK. Insights into Cell-Free Conversion of CO2 to Chemicals by a Multienzyme Cascade Reaction Acs Catalysis. 8: 11085-11093. DOI: 10.1021/Acscatal.8B02646  0.328
2017 Shi S, Zhao H. Metabolic Engineering of Oleaginous Yeasts for Production of Fuels and Chemicals. Frontiers in Microbiology. 8: 2185. PMID 29167664 DOI: 10.3389/Fmicb.2017.02185  0.375
2017 Lian J, HamediRad M, Hu S, Zhao H. Combinatorial metabolic engineering using an orthogonal tri-functional CRISPR system. Nature Communications. 8: 1688. PMID 29167442 DOI: 10.1038/S41467-017-01695-X  0.67
2017 Wei Y, Ang EL, Zhao H. Recent developments in the application of P450 based biocatalysts. Current Opinion in Chemical Biology. 43: 1-7. PMID 29100098 DOI: 10.1016/J.Cbpa.2017.08.006  0.638
2017 Si T, Li B, Comi TJ, Wu Y, Hu P, Wu Y, Min Y, Mitchell DA, Zhao H, Sweedler JV. Profiling of microbial colonies for high-throughput engineering of multi-step enzymatic reactions via optically guided MALDI MS. Journal of the American Chemical Society. PMID 28792758 DOI: 10.1021/Jacs.7B04641  0.615
2017 Shi S, Choi YW, Zhao H, Tan MH, Ang EL. Discovery and engineering of a 1-butanol biosensor in Saccharomyces cerevisiae. Bioresource Technology. PMID 28712783 DOI: 10.1016/J.Biortech.2017.06.114  0.656
2017 Sun H, Zhang H, Ang EL, Zhao H. Biocatalysis for the synthesis of pharmaceuticals and pharmaceutical intermediates. Bioorganic & Medicinal Chemistry. PMID 28709846 DOI: 10.1016/J.Bmc.2017.06.043  0.665
2017 Chao R, Mishra S, Si T, Zhao H. Engineering biological systems using automated biofoundries. Metabolic Engineering. PMID 28602523 DOI: 10.1016/J.Ymben.2017.06.003  0.536
2017 Si T, Chao R, Min Y, Wu Y, Ren W, Zhao H. Automated multiplex genome-scale engineering in yeast. Nature Communications. 8: 15187. PMID 28469255 DOI: 10.1038/Ncomms15187  0.561
2017 Ren H, Hu P, Zhao H. A plug-and-play pathway refactoring workflow for natural product research in Escherichia coli and Saccharomyces cerevisiae. Biotechnology and Bioengineering. PMID 28401530 DOI: 10.1002/Bit.26309  0.391
2017 Zhang MM, Wong FT, Wang Y, Luo S, Lim YH, Heng E, Yeo WL, Cobb RE, Enghiad B, Ang EL, Zhao H. CRISPR-Cas9 strategy for activation of silent Streptomyces biosynthetic gene clusters. Nature Chemical Biology. PMID 28398287 DOI: 10.1038/Nchembio.2341  0.641
2017 Liang J, Liu Z, Low XZ, Ang EL, Zhao H. Twin-primer non-enzymatic DNA assembly: an efficient and accurate multi-part DNA assembly method. Nucleic Acids Research. PMID 28334760 DOI: 10.1093/Nar/Gkx132  0.615
2017 Ren H, Wang B, Zhao H. Breaking the silence: new strategies for discovering novel natural products. Current Opinion in Biotechnology. 48: 21-27. PMID 28288336 DOI: 10.1016/J.Copbio.2017.02.008  0.4
2017 Zhang MM, Yuan Q, Ang EL, Zhao H. Using natural products for drug discovery: the impact of the genomics era. Expert Opinion On Drug Discovery. PMID 28277838 DOI: 10.1080/17460441.2017.1303478  0.66
2017 Xiong X, Zhang Y, Yan J, Jain S, Chee S, Ren B, Zhao H. A Scalable Epitope Tagging Approach for High Throughput ChIP-Seq Analysis. Acs Synthetic Biology. PMID 28215080 DOI: 10.1021/Acssynbio.6B00358  0.337
2017 Yeo WL, Chew X, Smith DJ, Chan KP, Sun H, Zhao H, Lim YH, Ang EL. Probing the molecular determinants of fluorinase specificity. Chemical Communications (Cambridge, England). PMID 28184383 DOI: 10.1039/C6Cc09213F  0.631
2017 Enghiad B, Zhao H. Programmable DNA-Guided Artificial Restriction Enzymes. Acs Synthetic Biology. PMID 28165224 DOI: 10.1021/Acssynbio.6B00324  0.32
2017 Freestone TS, Ju KS, Wang B, Zhao H. Discovery of a phosphonoacetic acid derived natural product by pathway refactoring. Acs Synthetic Biology. PMID 28103011 DOI: 10.1021/Acssynbio.6B00299  0.378
2017 Chao R, Liang J, Tasan I, Si T, Ju L, Zhao H. Fully automated one-step synthesis of single-transcript TALEN pairs using a biological foundry. Acs Synthetic Biology. PMID 28103009 DOI: 10.1021/Acssynbio.6B00293  0.777
2017 Liu Z, Liang Y, Ang EL, Zhao H. A New Era of Genome Integration - Simply Cut and Paste! Acs Synthetic Biology. PMID 28073246 DOI: 10.1021/Acssynbio.6B00331  0.63
2017 Wang Y, Bartlett MJ, Denard CA, Hartwig JF, Zhao H. Combining Rh-Catalyzed Diazocoupling and Enzymatic Reduction To Efficiently Synthesize Enantioenriched 2-Substituted Succinate Derivatives Acs Catalysis. 7: 2548-2552. DOI: 10.1021/Acscatal.7B00254  0.773
2016 Si T, Zhao H. A brief overview of synthetic biology research programs and roadmap studies in the United States. Synthetic and Systems Biotechnology. 1: 258-264. PMID 29062951 DOI: 10.1016/J.Synbio.2016.08.003  0.499
2016 Sun H, Yeo WL, Lim YH, Chew X, Smith DJ, Xue B, Chan KP, Robinson RC, Robins EG, Zhao H, Ang EL. Directed Evolution of a Fluorinase for Improved Fluorination Efficiency with a Non-native Substrate. Angewandte Chemie (International Ed. in English). PMID 27739177 DOI: 10.1002/Anie.201606722  0.656
2016 Garcia-Ruiz E, HamediRad M, Zhao H. Pathway Design, Engineering, and Optimization. Advances in Biochemical Engineering/Biotechnology. PMID 27629378 DOI: 10.1007/10_2016_12  0.381
2016 Si T, Zhao H. RNAi-Assisted Genome Evolution (RAGE) in Saccharomyces cerevisiae. Methods in Molecular Biology (Clifton, N.J.). 1470: 183-98. PMID 27581294 DOI: 10.1007/978-1-4939-6337-9_15  0.544
2016 Liang Y, Ang EL, Zhao H. A step through the looking glass. Science China. Life Sciences. PMID 27349997 DOI: 10.1007/S11427-016-0170-6  0.573
2016 Wendt KE, Ungerer J, Cobb RE, Zhao H, Pakrasi HB. CRISPR/Cas9 mediated targeted mutagenesis of the fast growing cyanobacterium Synechococcus elongatus UTEX 2973. Microbial Cell Factories. 15: 115. PMID 27339038 DOI: 10.1186/S12934-016-0514-7  0.36
2016 Zhao H, Medema MH. Standardization for natural product synthetic biology. Natural Product Reports. PMID 27313083 DOI: 10.1039/C6Np00030D  0.341
2016 Tasan I, Jain S, Zhao H. Use of genome-editing tools to treat sickle cell disease. Human Genetics. PMID 27250347 DOI: 10.1007/S00439-016-1688-0  0.306
2016 Shi S, Si T, Liu Z, Zhang H, Ang EL, Zhao H. Metabolic engineering of a synergistic pathway for n-butanol production in Saccharomyces cerevisiae. Scientific Reports. 6: 25675. PMID 27161023 DOI: 10.1038/Srep25675  0.729
2016 Lian J, Jin R, Zhao H. Construction of plasmids with tunable copy numbers in Saccharomyces cerevisiae and their applications in pathway optimization and multiplex genome integration. Biotechnology and Bioengineering. PMID 27159405 DOI: 10.1002/Bit.26004  0.663
2016 Quarterman J, Skerker JM, Feng X, Liu IY, Zhao H, Arkin AP, Jin YS. Rapid and efficient galactose fermentation by engineered Saccharomyces cerevisiae. Journal of Biotechnology. PMID 27140870 DOI: 10.1016/J.Jbiotec.2016.04.041  0.357
2016 Si T, Li B, Zhang K, Xu Y, Zhao H, Sweedler JV. Characterization of Bacillus subtilis Colony Biofilms via Mass Spectrometry and Fluorescence Imaging. Journal of Proteome Research. 15: 1955-62. PMID 27136705 DOI: 10.1021/Acs.Jproteome.6B00127  0.586
2016 Wang M, Zhao H. Combined and Iterative Use of Computational Design and Directed Evolution for Protein-Ligand Binding Design. Methods in Molecular Biology (Clifton, N.J.). 1414: 139-53. PMID 27094289 DOI: 10.1007/978-1-4939-3569-7_8  0.301
2016 Zhang MM, Wang Y, Ang EL, Zhao H. Engineering microbial hosts for production of bacterial natural products. Natural Product Reports. PMID 27072804 DOI: 10.1039/C6Np00017G  0.653
2016 Lian J, Zhao H. Functional Reconstitution of a Pyruvate Dehydrogenase in the Cytosol of Saccharomyces cerevisiae through Lipoylation Machinery Engineering. Acs Synthetic Biology. PMID 26991359 DOI: 10.1021/Acssynbio.6B00019  0.68
2016 Guo W, Sheng J, Zhao H, Feng X. Metabolic engineering of Saccharomyces cerevisiae to produce 1-hexadecanol from xylose. Microbial Cell Factories. 15: 24. PMID 26830023 DOI: 10.1186/S12934-016-0423-9  0.3
2016 Wang Y, Zhao H. Tandem Reactions Combining Biocatalysts and Chemical Catalysts for Asymmetric Synthesis Catalysts. 6: 194. DOI: 10.3390/Catal6120194  0.332
2016 Huang X, Guan Z, He L, Huang Y, Zhao H. A PNN prediction scheme for local tropical cyclone intensity over the South China Sea Natural Hazards. 81: 1249-1267. DOI: 10.1007/s11069-015-2132-9  0.317
2016 Zhang H, Li X, Su X, Ang EL, Zhang Y, Zhao H. Production of Adipic Acid from Sugar Beet Residue by Combined Biological and Chemical Catalysis Chemcatchem. DOI: 10.1002/Cctc.201600069  0.629
2015 Luo Y, Enghiad B, Zhao H. New tools for reconstruction and heterologous expression of natural product biosynthetic gene clusters. Natural Product Reports. PMID 26647833 DOI: 10.1039/C5Np00085H  0.383
2015 Shi S, Liang Y, Zhang MM, Lui Ang E, Zhao H. A highly efficient single-step, markerless strategy for multi-copy chromosomal integration of large biochemical pathways in Saccharomyces cerevisiae. Metabolic Engineering. PMID 26546089 DOI: 10.1016/J.Ymben.2015.10.011  0.367
2015 Bao Z, Cobb RE, Zhao H. Accelerated genome engineering through multiplexing. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. PMID 26394307 DOI: 10.1002/Wsbm.1319  0.342
2015 Yuan Y, Andersen E, Zhao H. Flexible and Versatile Strategy for the Construction of Large Biochemical Pathways. Acs Synthetic Biology. PMID 26332374 DOI: 10.1021/Acssynbio.5B00117  0.341
2015 Si T, HamediRad M, Zhao H. Regulatory RNA-assisted genome engineering in microorganisms. Current Opinion in Biotechnology. 36: 85-90. PMID 26319896 DOI: 10.1016/J.Copbio.2015.08.003  0.528
2015 Freestone TS, Zhao H. Combinatorial pathway engineering for optimized production of the anti-malarial FR900098. Biotechnology and Bioengineering. PMID 26245694 DOI: 10.1002/Bit.25719  0.357
2015 Li S, Si T, Wang M, Zhao H. Development of a Synthetic Malonyl-CoA Sensor in Saccharomyces cerevisiae for Intracellular Metabolite Monitoring and Genetic Screening. Acs Synthetic Biology. PMID 26149896 DOI: 10.1021/Acssynbio.5B00069  0.532
2015 Coursolle D, Lian J, Shanklin J, Zhao H. Production of long chain alcohols and alkanes upon coexpression of an acyl-ACP reductase and aldehyde-deformylating oxygenase with a bacterial type-I fatty acid synthase in E. coli. Molecular Biosystems. 11: 2464-72. PMID 26135500 DOI: 10.1039/C5Mb00268K  0.645
2015 Xiao H, Bao Z, Zhao H. High Throughput Screening and Selection Methods for Directed Enzyme Evolution. Industrial & Engineering Chemistry Research. 54: 4011-4020. PMID 26074668 DOI: 10.1021/Ie503060A  0.353
2015 Wang M, Li S, Zhao H. Design and engineering of intracellular-metabolite-sensing/regulation gene circuits in Saccharomyces cerevisiae. Biotechnology and Bioengineering. PMID 26059511 DOI: 10.1002/Bit.25676  0.365
2015 Luo Y, Li BZ, Liu D, Zhang L, Chen Y, Jia B, Zeng BX, Zhao H, Yuan YJ. Engineered biosynthesis of natural products in heterologous hosts. Chemical Society Reviews. 44: 5265-90. PMID 25960127 DOI: 10.1039/C5Cs00025D  0.358
2015 Guan ZB, Cai YJ, Zhang YZ, Zhao H, Liao XR. Complete genome sequence of Bacillus pumilus W3: A strain exhibiting high laccase activity. Journal of Biotechnology. 207: 8-9. PMID 25957807 DOI: 10.1016/j.jbiotec.2015.04.019  0.42
2015 Luo Y, Zhang L, Barton KW, Zhao H. Systematic Identification of a Panel of Strong Constitutive Promoters from Streptomyces albus. Acs Synthetic Biology. PMID 25924180 DOI: 10.1021/Acssynbio.5B00016  0.361
2015 Sun H, Liu Z, Zhao H, Ang EL. Recent advances in combinatorial biosynthesis for drug discovery. Drug Design, Development and Therapy. 9: 823-33. PMID 25709407 DOI: 10.2147/Dddt.S63023  0.685
2015 Denard CA, Ren H, Zhao H. Improving and repurposing biocatalysts via directed evolution. Current Opinion in Chemical Biology. 25: 55-64. PMID 25579451 DOI: 10.1016/J.Cbpa.2014.12.036  0.795
2015 Cobb RE, Bae B, Li Z, DeSieno MA, Nair SK, Zhao H. Structure-guided design and biosynthesis of a novel FR-900098 analogue as a potent Plasmodium falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase (Dxr) inhibitor. Chemical Communications (Cambridge, England). 51: 2526-8. PMID 25567100 DOI: 10.1039/C4Cc09181G  0.774
2015 Feng X, Lian J, Zhao H. Metabolic engineering of Saccharomyces cerevisiae to improve 1-hexadecanol production. Metabolic Engineering. 27: 10-9. PMID 25466225 DOI: 10.1016/J.Ymben.2014.10.001  0.642
2015 Cobb RE, Wang Y, Zhao H. High-efficiency multiplex genome editing of Streptomyces species using an engineered CRISPR/Cas system. Acs Synthetic Biology. 4: 723-8. PMID 25458909 DOI: 10.1021/Sb500351F  0.347
2015 Lian J, Zhao H. Recent advances in biosynthesis of fatty acids derived products in Saccharomyces cerevisiae via enhanced supply of precursor metabolites. Journal of Industrial Microbiology & Biotechnology. 42: 437-51. PMID 25306882 DOI: 10.1007/S10295-014-1518-0  0.631
2015 Bao Z, Xiao H, Liang J, Zhang L, Xiong X, Sun N, Si T, Zhao H. Homology-integrated CRISPR-Cas (HI-CRISPR) system for one-step multigene disruption in Saccharomyces cerevisiae. Acs Synthetic Biology. 4: 585-94. PMID 25207793 DOI: 10.1021/Sb500255K  0.611
2015 Lian J, Zhao H. Reversal of the β-oxidation cycle in Saccharomyces cerevisiae for production of fuels and chemicals. Acs Synthetic Biology. 4: 332-41. PMID 24959659 DOI: 10.1021/Sb500243C  0.648
2015 Si T, Luo Y, Bao Z, Zhao H. RNAi-assisted genome evolution in Saccharomyces cerevisiae for complex phenotype engineering. Acs Synthetic Biology. 4: 283-91. PMID 24758359 DOI: 10.1021/Sb500074A  0.579
2015 Denard CA, Bartlett MJ, Wang Y, Lu L, Hartwig JF, Zhao H. Development of a One-Pot tandem reaction combining ruthenium-catalyzed alkene metathesis and enantioselective enzymatic oxidation to produce Aryl epoxides Acs Catalysis. 5: 3817-3822. DOI: 10.1021/Acscatal.5B00533  0.774
2015 Cuculis LW, Abil Z, Zhao H, Schroeder CM. Direct Observation of TALE Protein Search Dynamics along DNA Biophysical Journal. 108: 205a-206a. DOI: 10.1016/J.Bpj.2014.11.1136  0.324
2015 Kan J, Huang S, Zhao H, Lin J, Su W. Photoinduced C-H direct arylation of unactivated arenes Science China Chemistry. 58: 1329-1333. DOI: 10.1007/S11426-015-5377-Y  0.457
2014 Si T, Xiao H, Zhao H. Rapid prototyping of microbial cell factories via genome-scale engineering. Biotechnology Advances. PMID 25450192 DOI: 10.1016/J.Biotechadv.2014.11.007  0.555
2014 Luo Y, Cobb RE, Zhao H. Recent advances in natural product discovery. Current Opinion in Biotechnology. 30: 230-7. PMID 25260043 DOI: 10.1016/J.Copbio.2014.09.002  0.336
2014 Xiao H, Shao Z, Jiang Y, Dole S, Zhao H. Exploiting Issatchenkia orientalis SD108 for succinic acid production. Microbial Cell Factories. 13: 121. PMID 25159171 DOI: 10.1186/S12934-014-0121-4  0.533
2014 Liang Y, Si T, Ang EL, Zhao H. Engineered pentafunctional minicellulosome for simultaneous saccharification and ethanol fermentation in Saccharomyces cerevisiae. Applied and Environmental Microbiology. 80: 6677-84. PMID 25149522 DOI: 10.1128/Aem.02070-14  0.723
2014 Chanco E, Choi YS, Sun N, Vu M, Zhao H. Characterization of the N-oxygenase AurF from Streptomyces thioletus. Bioorganic & Medicinal Chemistry. 22: 5569-77. PMID 24973817 DOI: 10.1016/J.Bmc.2014.06.002  0.45
2014 Xiao H, Zhao H. Genome-wide RNAi screen reveals the E3 SUMO-protein ligase gene SIZ1 as a novel determinant of furfural tolerance in Saccharomyces cerevisiae. Biotechnology For Biofuels. 7: 78. PMID 24904688 DOI: 10.1186/1754-6834-7-78  0.371
2014 Shao Z, Zhao H. Manipulating natural product biosynthetic pathways via DNA assembler. Current Protocols in Chemical Biology. 6: 65-100. PMID 24903884 DOI: 10.1002/9780470559277.Ch130191  0.533
2014 Lian J, Si T, Nair NU, Zhao H. Design and construction of acetyl-CoA overproducing Saccharomyces cerevisiae strains. Metabolic Engineering. 24: 139-49. PMID 24853351 DOI: 10.1016/J.Ymben.2014.05.010  0.787
2014 Wang M, Zhao H. Characterization and Engineering of the Adenylation Domain of a NRPS-Like Protein: A Potential Biocatalyst for Aldehyde Generation. Acs Catalysis. 4: 1219-1225. PMID 24804152 DOI: 10.1021/Cs500039V  0.357
2014 Jagtap SS, Singh R, Kang YC, Zhao H, Lee JK. Cloning and characterization of a galactitol 2-dehydrogenase from Rhizobium legumenosarum and its application in D-tagatose production. Enzyme and Microbial Technology. 58: 44-51. PMID 24731824 DOI: 10.1016/J.Enzmictec.2014.02.012  0.355
2014 Abil Z, Denard CA, Zhao H. Modular assembly of designer PUF proteins for specific post-transcriptional regulation of endogenous RNA. Journal of Biological Engineering. 8: 7. PMID 24581042 DOI: 10.1186/1754-1611-8-7  0.774
2014 Denard CA, Huang H, Bartlett MJ, Lu L, Tan Y, Zhao H, Hartwig JF. Cooperative tandem catalysis by an organometallic complex and a metalloenzyme. Angewandte Chemie (International Ed. in English). 53: 465-9. PMID 24536102 DOI: 10.1002/Anie.201305778  0.752
2014 Lian J, Chao R, Zhao H. Metabolic engineering of a Saccharomyces cerevisiae strain capable of simultaneously utilizing glucose and galactose to produce enantiopure (2R,3R)-butanediol. Metabolic Engineering. 23: 92-9. PMID 24525332 DOI: 10.1016/J.Ymben.2014.02.003  0.645
2014 Lian J, Li Y, HamediRad M, Zhao H. Directed evolution of a cellodextrin transporter for improved biofuel production under anaerobic conditions in Saccharomyces cerevisiae. Biotechnology and Bioengineering. 111: 1521-31. PMID 24519319 DOI: 10.1002/Bit.25214  0.648
2014 Sun N, Zhao H. A two-plasmid bacterial selection system for characterization and engineering of homing endonucleases. Methods in Molecular Biology (Clifton, N.J.). 1123: 87-96. PMID 24510262 DOI: 10.1007/978-1-62703-968-0_7  0.464
2014 Feng L, Zhao Y, Zhao H, Shao Z. Effects of storage time and temperature on coagulation tests and factors in fresh plasma. Scientific Reports. 4: 3868. PMID 24463857 DOI: 10.1038/srep03868  0.365
2014 Si T, Luo Y, Xiao H, Zhao H. Utilizing an endogenous pathway for 1-butanol production in Saccharomyces cerevisiae. Metabolic Engineering. 22: 60-8. PMID 24412568 DOI: 10.1016/J.Ymben.2014.01.002  0.577
2014 Wang M, Beissner M, Zhao H. Aryl-aldehyde formation in fungal polyketides: discovery and characterization of a distinct biosynthetic mechanism. Chemistry & Biology. 21: 257-63. PMID 24412543 DOI: 10.1016/J.Chembiol.2013.12.005  0.336
2014 Sun N, Zhao H. A single-chain TALEN architecture for genome engineering. Molecular Biosystems. 10: 446-53. PMID 24336919 DOI: 10.1039/C3Mb70412B  0.483
2014 Sun N, Bao Z, Xiong X, Zhao H. SunnyTALEN: a second-generation TALEN system for human genome editing. Biotechnology and Bioengineering. 111: 683-91. PMID 24255022 DOI: 10.1002/Bit.25154  0.443
2014 Liang J, Chao R, Abil Z, Bao Z, Zhao H. FairyTALE: a high-throughput TAL effector synthesis platform. Acs Synthetic Biology. 3: 67-73. PMID 24237314 DOI: 10.1021/Sb400109P  0.334
2014 Cobb RE, Ning JC, Zhao H. DNA assembly techniques for next-generation combinatorial biosynthesis of natural products. Journal of Industrial Microbiology & Biotechnology. 41: 469-77. PMID 24127070 DOI: 10.1007/S10295-013-1358-3  0.36
2014 Sun N, Zhao H. Seamless correction of the sickle cell disease mutation of the HBB gene in human induced pluripotent stem cells using TALENs. Biotechnology and Bioengineering. 111: 1048-53. PMID 23928856 DOI: 10.1002/Bit.25018  0.42
2014 Eriksen DT, Lian J, Zhao H. Protein design for pathway engineering. Journal of Structural Biology. 185: 234-42. PMID 23558037 DOI: 10.1016/J.Jsb.2013.03.011  0.692
2014 Huang H, Denard CA, Alamillo R, Crisci AJ, Miao Y, Dumesic JA, Scott SL, Zhao H. Tandem catalytic conversion of glucose to 5-hydroxymethylfurfural with an immobilized enzyme and a solid acid Acs Catalysis. 4: 2165-2168. DOI: 10.1021/Cs500591F  0.76
2014 Liang Y, Ang EL, Zhao H. Directed evolution of enzymes for industrial biocatalysis Industrial Biocatalysis. 73-114.  0.612
2013 Cobb RE, Chao R, Zhao H. Directed Evolution: Past, Present and Future. Aiche Journal. American Institute of Chemical Engineers. 59: 1432-1440. PMID 25733775 DOI: 10.1002/Aic.13995  0.339
2013 Luo Y, Huang H, Liang J, Wang M, Lu L, Shao Z, Cobb RE, Zhao H. Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene cluster. Nature Communications. 4: 2894. PMID 24305602 DOI: 10.1038/Ncomms3894  0.516
2013 Feng X, Zhao H. Investigating xylose metabolism in recombinant Saccharomyces cerevisiae via 13C metabolic flux analysis. Microbial Cell Factories. 12: 114. PMID 24245823 DOI: 10.1186/1475-2859-12-114  0.323
2013 Luo Y, Lee JK, Zhao H. Challenges and opportunities in synthetic biology for chemical engineers. Chemical Engineering Science. 103. PMID 24222925 DOI: 10.1016/J.Ces.2012.06.013  0.345
2013 Shao Z, Zhao H. Construction and engineering of large biochemical pathways via DNA assembler. Methods in Molecular Biology (Clifton, N.J.). 1073: 85-106. PMID 23996442 DOI: 10.1007/978-1-62703-625-2_9  0.559
2013 Shao Z, Rao G, Li C, Abil Z, Luo Y, Zhao H. Refactoring the silent spectinabilin gene cluster using a plug-and-play scaffold. Acs Synthetic Biology. 2: 662-9. PMID 23968564 DOI: 10.1021/Sb400058N  0.552
2013 Wen F, Zhao H. Construction and screening of an antigen-derived peptide library displayed on yeast cell surface for CD4+ T cell epitope identification. Methods in Molecular Biology (Clifton, N.J.). 1061: 245-64. PMID 23963942 DOI: 10.1007/978-1-62703-589-7_15  0.477
2013 Li S, Ha SJ, Kim HJ, Galazka JM, Cate JH, Jin YS, Zhao H. Investigation of the functional role of aldose 1-epimerase in engineered cellobiose utilization. Journal of Biotechnology. 168: 1-6. PMID 23954547 DOI: 10.1016/J.Jbiotec.2013.08.003  0.331
2013 Feng X, Zhao H. Investigating host dependence of xylose utilization in recombinant Saccharomyces cerevisiae strains using RNA-seq analysis. Biotechnology For Biofuels. 6: 96. PMID 23830104 DOI: 10.1186/1754-6834-6-96  0.301
2013 Eriksen DT, Hsieh PC, Lynn P, Zhao H. Directed evolution of a cellobiose utilization pathway in Saccharomyces cerevisiae by simultaneously engineering multiple proteins. Microbial Cell Factories. 12: 61. PMID 23802545 DOI: 10.1186/1475-2859-12-61  0.359
2013 Yuan Y, Zhao H. Directed evolution of a highly efficient cellobiose utilizing pathway in an industrial Saccharomyces cerevisiae strain. Biotechnology and Bioengineering. 110: 2874-81. PMID 23616289 DOI: 10.1002/Bit.24946  0.382
2013 Sun N, Zhao H. Transcription activator-like effector nucleases (TALENs): a highly efficient and versatile tool for genome editing. Biotechnology and Bioengineering. 110: 1811-21. PMID 23508559 DOI: 10.1002/Bit.24890  0.448
2013 Yuan Y, Du J, Zhao H. Customized optimization of metabolic pathways by combinatorial transcriptional engineering. Methods in Molecular Biology (Clifton, N.J.). 985: 177-209. PMID 23417805 DOI: 10.1007/978-1-62703-299-5_10  0.35
2013 Rao G, Lee JK, Zhao H. Directed evolution of phloroglucinol synthase PhlD with increased stability for phloroglucinol production. Applied Microbiology and Biotechnology. 97: 5861-7. PMID 23358999 DOI: 10.1007/S00253-013-4713-4  0.387
2013 Liang J, Ning JC, Zhao H. Coordinated induction of multi-gene pathways in Saccharomyces cerevisiae. Nucleic Acids Research. 41: e54. PMID 23262224 DOI: 10.1093/Nar/Gks1293  0.349
2013 Liang J, McLachlan MJ, Zhao H. Orthogonal control of endogenous gene expression in mammalian cells using synthetic ligands. Biotechnology and Bioengineering. 110: 1419-29. PMID 23242944 DOI: 10.1002/Bit.24807  0.742
2013 Kim B, Du J, Eriksen DT, Zhao H. Combinatorial design of a highly efficient xylose-utilizing pathway in Saccharomyces cerevisiae for the production of cellulosic biofuels. Applied and Environmental Microbiology. 79: 931-41. PMID 23183982 DOI: 10.1128/Aem.02736-12  0.404
2013 Cobb RE, Sun N, Zhao H. Directed evolution as a powerful synthetic biology tool. Methods (San Diego, Calif.). 60: 81-90. PMID 22465795 DOI: 10.1016/J.Ymeth.2012.03.009  0.494
2013 Zhang MM, Su X, Ang EL, Zhao H. Recent advances in biocatalyst development in the pharmaceutical industry Pharmaceutical Bioprocessing. 1: 179-196. DOI: 10.4155/Pbp.13.14  0.648
2013 Denard CA, Hartwig JF, Zhao H. Multistep one-pot reactions combining biocatalysts and chemical catalysts for asymmetric synthesis Acs Catalysis. 3: 2856-2864. DOI: 10.1021/Cs400633A  0.769
2013 Feng X, Zhao H. Investigating glucose and xylose metabolism in Saccharomyces cerevisiae and Scheffersomyces stipitis via 13C metabolic flux analysis Aiche Journal. 59: 3195-3202. DOI: 10.1002/Aic.14182  0.31
2012 Lu H, Chanco E, Zhao H. CmlI is an N-oxygenase in the biosynthesis of chloramphenicol. Tetrahedron. 68. PMID 24347692 DOI: 10.1016/J.Tet.2012.06.036  0.357
2012 Shao Z, Zhao H. DNA assembler: a synthetic biology tool for characterizing and engineering natural product gene clusters. Methods in Enzymology. 517: 203-24. PMID 23084940 DOI: 10.1016/B978-0-12-404634-4.00010-3  0.58
2012 Yang D, Zhou Y, Zhao H, Zhou X, Sun N, Wang B, Yuan X. Molecular cloning, sequencing, and expression analysis of cDNA encoding metalloprotein II (MP II) induced by single and combined metals (Cu(II), Cd(II)) in polychaeta Perinereis aibuhitensis. Environmental Toxicology and Pharmacology. 34: 841-8. PMID 23063649 DOI: 10.1016/j.etap.2012.09.001  0.315
2012 Wen S, Tan T, Zhao H. Improving the thermostability of lipase Lip2 from Yarrowia lipolytica. Journal of Biotechnology. 164: 248-53. PMID 22982168 DOI: 10.1016/J.Jbiotec.2012.08.023  0.364
2012 Sun N, Abil Z, Zhao H. Recent advances in targeted genome engineering in mammalian systems. Biotechnology Journal. 7: 1074-87. PMID 22777886 DOI: 10.1002/Biot.201200038  0.476
2012 Du J, Yuan Y, Si T, Lian J, Zhao H. Customized optimization of metabolic pathways by combinatorial transcriptional engineering. Nucleic Acids Research. 40: e142. PMID 22718979 DOI: 10.1093/Nar/Gks549  0.736
2012 Shao Z, Luo Y, Zhao H. DNA assembler method for construction of zeaxanthin-producing strains of Saccharomyces cerevisiae. Methods in Molecular Biology (Clifton, N.J.). 898: 251-62. PMID 22711131 DOI: 10.1007/978-1-61779-918-1_17  0.555
2012 Cobb RE, Si T, Zhao H. Directed evolution: an evolving and enabling synthetic biology tool. Current Opinion in Chemical Biology. 16: 285-91. PMID 22673064 DOI: 10.1016/J.Cbpa.2012.05.186  0.547
2012 Cobb RE, Zhao H. Direct cloning of large genomic sequences. Nature Biotechnology. 30: 405-6. PMID 22565964 DOI: 10.1038/Nbt.2207  0.332
2012 Zou Y, Zhang H, Brunzelle JS, Johannes TW, Woodyer R, Hung JE, Nair N, Van Der Donk WA, Zhao H, Nair SK. Crystal structures of phosphite dehydrogenase provide insights into nicotinamide cofactor regeneration Biochemistry. 51: 4263-4270. PMID 22564171 DOI: 10.1021/Bi2016926  0.788
2012 Hung JE, Fogle EJ, Christman HD, Johannes TW, Zhao H, Metcalf WW, Van Der Donk WA. Investigation of the role of Arg301 identified in the X-ray structure of phosphite dehydrogenase Biochemistry. 51: 4254-4262. PMID 22564138 DOI: 10.1021/Bi201691W  0.759
2012 Tiwari MK, Singh RK, Singh R, Jeya M, Zhao H, Lee JK. Role of conserved glycine in zinc-dependent medium chain dehydrogenase/reductase superfamily. The Journal of Biological Chemistry. 287: 19429-39. PMID 22500022 DOI: 10.1074/Jbc.M111.335752  0.321
2012 Sun J, Wen F, Si T, Xu JH, Zhao H. Direct conversion of xylan to ethanol by recombinant Saccharomyces cerevisiae strains displaying an engineered minihemicellulosome. Applied and Environmental Microbiology. 78: 3837-45. PMID 22447594 DOI: 10.1128/Aem.07679-11  0.658
2012 Sun J, Shao Z, Zhao H, Nair N, Wen F, Xu JH, Zhao H. Cloning and characterization of a panel of constitutive promoters for applications in pathway engineering in Saccharomyces cerevisiae. Biotechnology and Bioengineering. 109: 2082-92. PMID 22383307 DOI: 10.1002/Bit.24481  0.74
2012 Wang M, Si T, Zhao H. Biocatalyst development by directed evolution. Bioresource Technology. 115: 117-25. PMID 22310212 DOI: 10.1016/J.Biortech.2012.01.054  0.6
2012 Sun N, Liang J, Abil Z, Zhao H. Optimized TAL effector nucleases (TALENs) for use in treatment of sickle cell disease. Molecular Biosystems. 8: 1255-63. PMID 22301904 DOI: 10.1039/C2Mb05461B  0.457
2012 Tiwari MK, Singh RK, Lee JK, Zhao H. Mechanistic studies on the flavin:NADH reductase (PrnF) from Pseudomonas fluorescens involved in arylamine oxygenation. Bioorganic & Medicinal Chemistry Letters. 22: 1344-7. PMID 22225642 DOI: 10.1016/J.Bmcl.2011.12.078  0.301
2012 Nair NU, Zhao H. Mutagenic Inverted Repeats Assisted Genome Engineering (MIRAGE) in Saccharomyces cerevisiae: deletion of gal7. Methods in Molecular Biology (Clifton, N.J.). 834: 63-73. PMID 22144353 DOI: 10.1007/978-1-61779-483-4_5  0.607
2011 Ghosh A, Zhao H, Price ND. Genome-scale consequences of cofactor balancing in engineered pentose utilization pathways in Saccharomyces cerevisiae. Plos One. 6: e27316. PMID 22076150 DOI: 10.1371/Journal.Pone.0027316  0.374
2011 Li J, Luo Y, Lee JK, Zhao H. Cloning and characterization of a type III polyketide synthase from Aspergillus niger. Bioorganic & Medicinal Chemistry Letters. 21: 6085-9. PMID 21903388 DOI: 10.1016/J.Bmcl.2011.08.058  0.375
2011 Bae B, Cobb RE, DeSieno MA, Zhao H, Nair SK. New N-acetyltransferase fold in the structure and mechanism of the phosphonate biosynthetic enzyme FrbF. The Journal of Biological Chemistry. 286: 36132-41. PMID 21865168 DOI: 10.1074/Jbc.M111.263533  0.79
2011 Desieno MA, Van Der Donk WA, Zhao H. Characterization and application of the Fe(ii) and α-ketoglutarate dependent hydroxylase FrbJ Chemical Communications. 47: 10025-10027. PMID 21829824 DOI: 10.1039/C1Cc13597J  0.763
2011 Wen F, Sethi DK, Wucherpfennig KW, Zhao H. Cell surface display of functional human MHC class II proteins: yeast display versus insect cell display. Protein Engineering, Design & Selection : Peds. 24: 701-9. PMID 21752831 DOI: 10.1093/Protein/Gzr035  0.513
2011 McLachlan MJ, Katzenellenbogen JA, Zhao H. A new fluorescence complementation biosensor for detection of estrogenic compounds. Biotechnology and Bioengineering. 108: 2794-803. PMID 21732327 DOI: 10.1002/Bit.23254  0.732
2011 Evans BS, Chen Y, Metcalf WW, Zhao H, Kelleher NL. Directed evolution of the nonribosomal peptide synthetase AdmK generates new andrimid derivatives in vivo. Chemistry & Biology. 18: 601-7. PMID 21609841 DOI: 10.1016/J.Chembiol.2011.03.008  0.398
2011 Du J, Shao Z, Zhao H. Engineering microbial factories for synthesis of value-added products. Journal of Industrial Microbiology & Biotechnology. 38: 873-90. PMID 21526386 DOI: 10.1007/S10295-011-0970-3  0.549
2011 Shao Z, Luo Y, Zhao H. Rapid characterization and engineering of natural product biosynthetic pathways via DNA assembler. Molecular Biosystems. 7: 1056-9. PMID 21327279 DOI: 10.1039/C0Mb00338G  0.545
2011 Liang J, Luo Y, Zhao H. Synthetic biology: putting synthesis into biology. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 3: 7-20. PMID 21064036 DOI: 10.1002/Wsbm.104  0.333
2011 Zhao H. Highlights of biocatalysis and biomimetic catalysis Acs Catalysis. 1: 1119-1120. DOI: 10.1021/Cs200425R  0.327
2011 Desieno M, Du J, Zhao H. Altering Enzyme Substrate and Cofactor Specificity via Protein Engineering Protein Engineering Handbook, Volume 1 & Volume 2. 2: 777-796. DOI: 10.1002/9783527634026.ch31  0.799
2011 Desieno MA, Denard CA, Zhao H. Drug Discovery and Development by Combinatorial Biosynthesis Enzyme Technologies: Metagenomics, Evolution, Biocatalysis, and Biosynthesis. 251-283. DOI: 10.1002/9780470627303.ch8  0.746
2010 Bae B, Sullivan RP, Zhao H, Nair SK. Structure and engineering of L-arabinitol 4-dehydrogenase from Neurospora crassa. Journal of Molecular Biology. 402: 230-40. PMID 20655316 DOI: 10.1016/J.Jmb.2010.07.033  0.597
2010 Tang WL, Li Z, Zhao H. Inverting the enantioselectivity of P450pyr monooxygenase by directed evolution. Chemical Communications (Cambridge, England). 46: 5461-3. PMID 20520890 DOI: 10.1039/C0Cc00735H  0.575
2010 Rubin-Pitel SB, Luo Y, Lee JK, Zhao H. A diverse family of Type III polyketide synthases in Eucalyptus species. Molecular Biosystems. 6: 1444-6. PMID 20517538 DOI: 10.1039/C004992A  0.333
2010 Nair NU, Zhao H. Selective reduction of xylose to xylitol from a mixture of hemicellulosic sugars. Metabolic Engineering. 12: 462-8. PMID 20447465 DOI: 10.1016/J.Ymben.2010.04.005  0.579
2010 Kim B, Sullivan RP, Zhao H. Cloning, characterization, and engineering of fungal L-arabinitol dehydrogenases. Applied Microbiology and Biotechnology. 87: 1407-14. PMID 20414651 DOI: 10.1007/S00253-010-2593-4  0.586
2010 Johannes TW, DeSieno MA, Griffin BM, Thomas PM, Kelleher NL, Metcalf WW, Zhao H. Deciphering the late biosynthetic steps of antimalarial compound FR-900098. Chemistry & Biology. 17: 57-64. PMID 20142041 DOI: 10.1016/J.Chembiol.2009.12.009  0.796
2010 Choi YS, Johannes TW, Simurdiak M, Shao Z, Lu H, Zhao H. Cloning and heterologous expression of the spectinabilin biosynthetic gene cluster from Streptomyces spectabilis. Molecular Biosystems. 6: 336-8. PMID 20094652 DOI: 10.1039/B923177C  0.716
2010 Wen F, Sun J, Zhao H. Yeast surface display of trifunctional minicellulosomes for simultaneous saccharification and fermentation of cellulose to ethanol. Applied and Environmental Microbiology. 76: 1251-60. PMID 20023102 DOI: 10.1128/Aem.01687-09  0.556
2010 Nair NU, Denard CA, Zhao H. Engineering of enzymes for selective catalysis Current Organic Chemistry. 14: 1870-1882. DOI: 10.2174/138527210792927537  0.802
2009 Sun N, Zhao H. Reconstructing transcriptional regulatory networks through genomics data. Statistical Methods in Medical Research. 18: 595-617. PMID 20048387 DOI: 10.1177/0962280209351890  0.305
2009 He YX, Huang L, Xue Y, Fei X, Teng YB, Rubin-Pitel SB, Zhao H, Zhou CZ. Crystal structure and computational analyses provide insights into the catalytic mechanism of 2,4-diacetylphloroglucinol hydrolase PhlG from Pseudomonas fluorescens. The Journal of Biological Chemistry. 285: 4603-11. PMID 20018877 DOI: 10.1074/Jbc.M109.044180  0.33
2009 Tang WL, Zhao H. Industrial biotechnology: tools and applications. Biotechnology Journal. 4: 1725-39. PMID 19844915 DOI: 10.1002/Biot.200900127  0.603
2009 McLachlan MJ, Chockalingam K, Lai KC, Zhao H. Directed evolution of orthogonal ligand specificity in a single scaffold. Angewandte Chemie (International Ed. in English). 48: 7783-6. PMID 19746501 DOI: 10.1002/Anie.200903413  0.765
2009 Wen F, Nair NU, Zhao H. Protein engineering in designing tailored enzymes and microorganisms for biofuels production. Current Opinion in Biotechnology. 20: 412-9. PMID 19660930 DOI: 10.1016/J.Copbio.2009.07.001  0.706
2009 Liu W, Shi HM, Jin H, Zhao HY, Zhou GP, Wen F, Yu ZY, Hou TP. Design, synthesis and antifungal activity of a series of novel analogs based on diphenyl ketones. Chemical Biology & Drug Design. 73: 661-7. PMID 19635058 DOI: 10.1111/j.1747-0285.2009.00820.x  0.414
2009 Zha W, Rubin-Pitel SB, Shao Z, Zhao H. Improving cellular malonyl-CoA level in Escherichia coli via metabolic engineering. Metabolic Engineering. 11: 192-8. PMID 19558964 DOI: 10.1016/J.Ymben.2009.01.005  0.689
2009 Chen Z, Wen F, Sun N, Zhao H. Directed evolution of homing endonuclease I-SceI with altered sequence specificity. Protein Engineering, Design & Selection : Peds. 22: 249-56. PMID 19176595 DOI: 10.1093/Protein/Gzp001  0.734
2009 Jiao Y, Tausta SL, Gandotra N, Sun N, Liu T, Clay NK, Ceserani T, Chen M, Ma L, Holford M, Zhang HY, Zhao H, Deng XW, Nelson T. A transcriptome atlas of rice cell types uncovers cellular, functional and developmental hierarchies. Nature Genetics. 41: 258-63. PMID 19122662 DOI: 10.1038/Ng.282  0.303
2009 Islam KMD, Dilcher M, Thurow C, Vock C, Krimmelbein IK, Tietze LF, Gonzalez V, Zhao H, Gatz C. Directed evolution of estrogen receptor proteins with altered ligand-binding specificities Protein Engineering, Design and Selection. 22: 45-52. PMID 19088113 DOI: 10.1093/Protein/Gzn067  0.304
2009 Shao Z, Zhao H, Zhao H. DNA assembler, an in vivo genetic method for rapid construction of biochemical pathways. Nucleic Acids Research. 37: e16. PMID 19074487 DOI: 10.1093/Nar/Gkn991  0.534
2009 Nair NU, Zhao H. Mutagenic inverted repeat assisted genome engineering (MIRAGE). Nucleic Acids Research. 37: e9. PMID 19050015 DOI: 10.1093/Nar/Gkn943  0.601
2009 Ang EL, Obbard JP, Zhao H. Directed evolution of aniline dioxygenase for enhanced bioremediation of aromatic amines. Applied Microbiology and Biotechnology. 81: 1063-70. PMID 18813921 DOI: 10.1007/S00253-008-1710-0  0.644
2009 McLachlan MJ, Sullivan RP, Zhao H. Directed Enzyme Evolution and High-Throughput Screening Biocatalysis For the Pharmaceutical Industry: Discovery, Development, and Manufacturing. 45-64. DOI: 10.1002/9780470823163.ch3  0.784
2008 Meng QQ, Chen BA, Wu W, Shao ZY, Gao F, Zhao HH. [Antitumor effects of low-frequency ultrasound combined with adriamycin on human leukemia multidrug resistance cell line K562/A02]. Ai Zheng = Aizheng = Chinese Journal of Cancer. 27: 1182-5. PMID 19000450  0.358
2008 Rubin-Pitel SB, Zhang H, Vu T, Brunzelle JS, Zhao H, Nair SK. Distinct structural elements dictate the specificity of the type III pentaketide synthase from Neurospora crassa. Chemistry & Biology. 15: 1079-90. PMID 18940668 DOI: 10.1016/J.Chembiol.2008.08.011  0.327
2008 Eliot AC, Griffin BM, Thomas PM, Johannes TW, Kelleher NL, Zhao H, Metcalf WW. Cloning, expression, and biochemical characterization of Streptomyces rubellomurinus genes required for biosynthesis of antimalarial compound FR900098. Chemistry & Biology. 15: 765-70. PMID 18721747 DOI: 10.1016/J.Chembiol.2008.07.010  0.717
2008 Shao Z, Blodgett JA, Circello BT, Eliot AC, Woodyer R, Li G, van der Donk WA, Metcalf WW, Zhao H. Biosynthesis of 2-hydroxyethylphosphonate, an unexpected intermediate common to multiple phosphonate biosynthetic pathways. The Journal of Biological Chemistry. 283: 23161-8. PMID 18544530 DOI: 10.1074/Jbc.M801788200  0.797
2008 Choi YS, Zhang H, Brunzelle JS, Nair SK, Zhao H. In vitro reconstitution and crystal structure of p-aminobenzoate N-oxygenase (AurF) involved in aureothin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 105: 6858-63. PMID 18458342 DOI: 10.1073/Pnas.0712073105  0.319
2008 Wen F, Esteban O, Zhao H. Rapid identification of CD4+ T-cell epitopes using yeast displaying pathogen-derived peptide library. Journal of Immunological Methods. 336: 37-44. PMID 18448115 DOI: 10.1016/J.Jim.2008.03.008  0.492
2008 Zha W, Rubin-Pitel SB, Zhao H. Exploiting genetic diversity by directed evolution: molecular breeding of type III polyketide synthases improves productivity. Molecular Biosystems. 4: 246-8. PMID 18437267 DOI: 10.1039/B717705D  0.618
2008 Nair NU, Zhao H. Evolution in reverse: engineering a D-xylose-specific xylose reductase. Chembiochem : a European Journal of Chemical Biology. 9: 1213-5. PMID 18383056 DOI: 10.1002/Cbic.200700765  0.614
2008 McLachlan MJ, Johannes TW, Zhao H. Further improvement of phosphite dehydrogenase thermostability by saturation mutagenesis. Biotechnology and Bioengineering. 99: 268-74. PMID 17615560 DOI: 10.1002/Bit.21546  0.8
2007 Chen BA, Zhao HH, Gao C, Shao ZY, Xia GH, Dohner K. [Effects of sodium valproate on proliferation and apoptosis of human myelodysplastic syndromes cell line MUTZ-1]. Ai Zheng = Aizheng = Chinese Journal of Cancer. 26: 1323-9. PMID 18076794  0.357
2007 Sullivan R, Zhao H. Cloning, characterization, and mutational analysis of a highly active and stable L-arabinitol 4-dehydrogenase from Neurospora crassa Applied Microbiology and Biotechnology. 77: 845-852. PMID 17938906 DOI: 10.1007/S00253-007-1225-0  0.591
2007 Lee JK, Zhao H. Identification and characterization of the flavin:NADH reductase (PrnF) involved in a novel two-component arylamine oxygenase. Journal of Bacteriology. 189: 8556-63. PMID 17921302 DOI: 10.1128/Jb.01050-07  0.325
2007 Zhao H. Directed evolution of novel protein functions Biotechnology and Bioengineering. 98: 313-317. PMID 17721862 DOI: 10.1002/Bit.21455  0.315
2007 Zhao HH, Chen BA, Gao C, Shao ZY, Xia GH, Ding JH, Sun YY, Wang J, Cheng J, Zhao G, Dohner K, Dohner H. [Apoptosis of human myelodysplastic syndrome cell Line MUTZ-1 induced by sodium valproate]. Zhongguo Shi Yan Xue Ye Xue Za Zhi / Zhongguo Bing Li Sheng Li Xue Hui = Journal of Experimental Hematology / Chinese Association of Pathophysiology. 15: 743-7. PMID 17708795  0.359
2007 Ang EL, Obbard JP, Zhao H. Probing the molecular determinants of aniline dioxygenase substrate specificity by saturation mutagenesis. The Febs Journal. 274: 928-39. PMID 17269935 DOI: 10.1111/J.1742-4658.2007.05638.X  0.664
2007 Nair N, Zhao H. Biochemical characterization of an L-xylulose reductase from Neurospora crassa Applied and Environmental Microbiology. 73: 2001-2004. PMID 17261518 DOI: 10.1128/Aem.02515-06  0.592
2007 Woodyer RD, Li G, Zhao H, van der Donk WA. New insight into the mechanism of methyl transfer during the biosynthesis of fosfomycin. Chemical Communications (Cambridge, England). 359-61. PMID 17220970 DOI: 10.1039/B614678C  0.766
2007 Johannes TW, Woodyer RD, Zhao H. Efficient regeneration of NADPH using an engineered phosphite dehydrogenase. Biotechnology and Bioengineering. 96: 18-26. PMID 16948172 DOI: 10.1002/Bit.21168  0.808
2006 Zhao H, Zha W. In vitro 'sexual' evolution through the PCR-based staggered extension process (StEP). Nature Protocols. 1: 1865-71. PMID 17487170 DOI: 10.1038/Nprot.2006.309  0.559
2006 Woodyer RD, Shao Z, Thomas PM, Kelleher NL, Blodgett JA, Metcalf WW, van der Donk WA, Zhao H. Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster. Chemistry & Biology. 13: 1171-82. PMID 17113999 DOI: 10.1016/J.Chembiol.2006.09.007  0.787
2006 Chockalingam K, Luba J, Nick HS, Silverman DN, Zhao H. Engineering and characterization of human manganese superoxide dismutase mutants with high activity and low product inhibition. The Febs Journal. 273: 4853-61. PMID 16999822 DOI: 10.1111/J.1742-4658.2006.05484.X  0.71
2006 Zha W, Rubin-Pitel SB, Zhao H. Characterization of the substrate specificity of PhlD, a type III polyketide synthase from Pseudomonas fluorescens. The Journal of Biological Chemistry. 281: 32036-47. PMID 16931521 DOI: 10.1074/Jbc.M606500200  0.587
2006 Lee JK, Ang EL, Zhao H. Probing the substrate specificity of aminopyrrolnitrin oxygenase (PrnD) by mutational analysis. Journal of Bacteriology. 188: 6179-83. PMID 16923884 DOI: 10.1128/Jb.00259-06  0.646
2006 Rubin-Pitel SB, Zhao H. Recent advances in biocatalysis by directed enzyme evolution. Combinatorial Chemistry & High Throughput Screening. 9: 247-57. PMID 16724916 DOI: 10.2174/138620706776843183  0.397
2006 Woodyer R, van der Donk WA, Zhao H. Optimizing a biocatalyst for improved NAD(P)H regeneration: directed evolution of phosphite dehydrogenase. Combinatorial Chemistry & High Throughput Screening. 9: 237-45. PMID 16724915 DOI: 10.2174/138620706776843246  0.808
2006 Sun N, Carroll RJ, Zhao H. Bayesian error analysis model for reconstructing transcriptional regulatory networks. Proceedings of the National Academy of Sciences of the United States of America. 103: 7988-93. PMID 16702552 DOI: 10.1073/Pnas.0600164103  0.323
2006 Johannes TW, Zhao H. Directed evolution of enzymes and biosynthetic pathways. Current Opinion in Microbiology. 9: 261-7. PMID 16621678 DOI: 10.1016/J.Mib.2006.03.003  0.745
2006 Xie D, Shao Z, Achkar J, Zha W, Frost JW, Zhao H. Microbial synthesis of triacetic acid lactone. Biotechnology and Bioengineering. 93: 727-36. PMID 16245348 DOI: 10.1002/Bit.20759  0.677
2006 Johannes TW, Woodyer RD, Zhao H. High-throughput Screening Methods Developed for Oxidoreductases Enzyme Assays: High-Throughput Screening, Genetic Selection and Fingerprinting. 77-93. DOI: 10.1002/3527607846.ch3  0.758
2005 Chen Z, Zhao H. A highly sensitive selection method for directed evolution of homing endonucleases. Nucleic Acids Research. 33: e154. PMID 16214805 DOI: 10.1093/Nar/Gni148  0.669
2005 Johannes TW, Woodyer RD, Zhao H. Directed evolution of a thermostable phosphite dehydrogenase for NAD(P)H regeneration. Applied and Environmental Microbiology. 71: 5728-34. PMID 16204481 DOI: 10.1128/Aem.71.10.5728-5734.2005  0.805
2005 Lee J, Simurdiak M, Zhao H. Reconstitution and characterization of aminopyrrolnitrin oxygenase, a Rieske N-oxygenase that catalyzes unusual arylamine oxidation. The Journal of Biological Chemistry. 280: 36719-27. PMID 16150698 DOI: 10.1074/Jbc.M505334200  0.344
2005 Ma L, Chen C, Liu X, Jiao Y, Su N, Li L, Wang X, Cao M, Sun N, Zhang X, Bao J, Li J, Pedersen S, Bolund L, Zhao H, et al. A microarray analysis of the rice transcriptome and its comparison to Arabidopsis. Genome Research. 15: 1274-83. PMID 16140994 DOI: 10.1101/Gr.3657405  0.332
2005 Woodyer R, Zhao H, van der Donk WA. Mechanistic investigation of a highly active phosphite dehydrogenase mutant and its application for NADPH regeneration. The Febs Journal. 272: 3816-27. PMID 16045753 DOI: 10.1111/J.1742-4658.2005.04788.X  0.795
2005 Chockalingam K, Zhao H. Creating new specific ligand-receptor pairs for transgene regulation. Trends in Biotechnology. 23: 333-5. PMID 15978316 DOI: 10.1016/J.Tibtech.2005.05.002  0.682
2005 Ma L, Sun N, Liu X, Jiao Y, Zhao H, Deng XW. Organ-specific expression of Arabidopsis genome during development. Plant Physiology. 138: 80-91. PMID 15888681 DOI: 10.1104/Pp.104.054783  0.31
2005 Chen Z, Zhao H. Rapid creation of a novel protein function by in vitro coevolution. Journal of Molecular Biology. 348: 1273-82. PMID 15854660 DOI: 10.1016/J.Jmb.2005.02.070  0.661
2005 Achkar J, Xian M, Zhao H, Frost JW. Biosynthesis of phloroglucinol. Journal of the American Chemical Society. 127: 5332-3. PMID 15826166 DOI: 10.1021/Ja042340G  0.36
2005 Chockalingam K, Chen Z, Katzenellenbogen JA, Zhao H. Directed evolution of specific receptor-ligand pairs for use in the creation of gene switches. Proceedings of the National Academy of Sciences of the United States of America. 102: 5691-6. PMID 15811944 DOI: 10.1073/Pnas.0409206102  0.767
2005 Woodyer R, Simurdiak M, van der Donk WA, Zhao H. Heterologous expression, purification, and characterization of a highly active xylose reductase from Neurospora crassa. Applied and Environmental Microbiology. 71: 1642-7. PMID 15746370 DOI: 10.1128/Aem.71.3.1642-1647.2005  0.801
2005 Ang EL, Zhao H, Obbard JP. Recent advances in the bioremediation of persistent organic pollutants via biomolecular engineering Enzyme and Microbial Technology. 37: 487-496. DOI: 10.1016/J.Enzmictec.2004.07.024  0.671
2004 Esteban O, Zhao H. Directed evolution of soluble single-chain human class II MHC molecules. Journal of Molecular Biology. 340: 81-95. PMID 15184024 DOI: 10.1016/J.Jmb.2004.04.054  0.307
2004 Chen Z, Katzenellenbogen BS, Katzenellenbogen JA, Zhao H. Directed evolution of human estrogen receptor variants with significantly enhanced androgen specificity and affinity. The Journal of Biological Chemistry. 279: 33855-64. PMID 15159406 DOI: 10.1074/Jbc.M402118200  0.628
2004 Zha W, Shao Z, Frost JW, Zhao H. Rational pathway engineering of type I fatty acid synthase allows the biosynthesis of triacetic acid lactone from D-glucose in vivo. Journal of the American Chemical Society. 126: 4534-5. PMID 15070368 DOI: 10.1021/Ja0317271  0.678
2004 Sun N, Zhao H. Genomic approaches in dissecting complex biological pathways. Pharmacogenomics. 5: 163-79. PMID 15016608 DOI: 10.1517/phgs.5.2.163.27488  0.324
2004 Woodyer R, Chen W, Zhao H. Outrunning Nature: Directed Evolution of Superior Biocatalysts Journal of Chemical Education. 81: 126. DOI: 10.1021/Ed081P126  0.773
2003 Sun N, Ma L, Pan D, Zhao H, Deng XW. Evaluation of light regulatory potential of Calvin cycle steps based on large-scale gene expression profiling data. Plant Molecular Biology. 53: 467-78. PMID 15010613 DOI: 10.1023/B:PLAN.0000019071.12878.9e  0.34
2003 Zhao H, van der Donk WA. Regeneration of cofactors for use in biocatalysis. Current Opinion in Biotechnology. 14: 583-9. PMID 14662386 DOI: 10.1016/J.Copbio.2003.09.007  0.544
2003 Pan D, Sun N, Cheung KH, Guan Z, Ma L, Holford M, Deng X, Zhao H. PathMAPA: a tool for displaying gene expression and performing statistical tests on metabolic pathways at multiple levels for Arabidopsis. Bmc Bioinformatics. 4: 56. PMID 14604444 DOI: 10.1186/1471-2105-4-56  0.372
2003 Woodyer R, van der Donk WA, Zhao H. Relaxing the nicotinamide cofactor specificity of phosphite dehydrogenase by rational design. Biochemistry. 42: 11604-14. PMID 14529270 DOI: 10.1021/Bi035018B  0.802
2003 van der Donk WA, Zhao H. Recent developments in pyridine nucleotide regeneration. Current Opinion in Biotechnology. 14: 421-6. PMID 12943852 DOI: 10.1016/S0958-1669(03)00094-6  0.571
2003 Esteban O, Woodyer RD, Zhao H. In vitro DNA recombination by random priming. Methods in Molecular Biology (Clifton, N.J.). 231: 99-104. PMID 12824607 DOI: 10.1385/1-59259-395-X:99  0.716
2003 Zha W, Zhu T, Zhao H. Family shuffling with single-stranded DNA. Methods in Molecular Biology (Clifton, N.J.). 231: 91-7. PMID 12824606 DOI: 10.1385/1-59259-395-X:91  0.507
2003 Chen Z, Zhao H. A highly efficient and sensitive screening method for trans-activation activity of estrogen receptors. Gene. 306: 127-34. PMID 12657474 DOI: 10.1016/S0378-1119(03)00431-1  0.635
2002 Zhao H, Chockalingam K, Chen Z. Directed evolution of enzymes and pathways for industrial biocatalysis. Current Opinion in Biotechnology. 13: 104-10. PMID 11950559 DOI: 10.1016/S0958-1669(02)00291-4  0.789
1999 Arnold FH, Giver L, Gershenson A, Zhao H, Miyazaki K. Directed evolution of mesophilic enzymes into their thermophilic counterparts. Annals of the New York Academy of Sciences. 870: 400-3. PMID 10415508 DOI: 10.1111/J.1749-6632.1999.Tb08913.X  0.524
1999 Zhao H, Arnold FH. Directed evolution converts subtilisin E into a functional equivalent of thermitase. Protein Engineering. 12: 47-53. PMID 10065710 DOI: 10.1093/Protein/12.1.47  0.525
1998 Zhao H, Giver L, Shao Z, Affholter JA, Arnold FH. Molecular evolution by staggered extension process (StEP) in vitro recombination. Nature Biotechnology. 16: 258-61. PMID 9528005 DOI: 10.1038/Nbt0398-258  0.631
1998 Shao Z, Zhao H, Giver L, Arnold FH. Random-priming in vitro recombination: an effective tool for directed evolution. Nucleic Acids Research. 26: 681-3. PMID 9421535 DOI: 10.1093/Nar/26.2.681  0.653
1997 Zhao H, Arnold FH. Combinatorial protein design: strategies for screening protein libraries. Current Opinion in Structural Biology. 7: 480-5. PMID 9266168 DOI: 10.1016/S0959-440X(97)80110-8  0.473
1997 Zhao H, Arnold FH. Functional and nonfunctional mutations distinguished by random recombination of homologous genes. Proceedings of the National Academy of Sciences of the United States of America. 94: 7997-8000. PMID 9223302 DOI: 10.1073/Pnas.94.15.7997  0.475
1997 Zhao H, Arnold FH. Optimization of DNA shuffling for high fidelity recombination. Nucleic Acids Research. 25: 1307-8. PMID 9092645 DOI: 10.1093/Nar/25.6.1307  0.498
1996 Zhao H, Li Y, Arnold FH. Strategy for the directed evolution of a peptide ligase. Annals of the New York Academy of Sciences. 799: 1-5. PMID 8958065 DOI: 10.1111/J.1749-6632.1996.Tb33169.X  0.439
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