Hayato Ishikawa, PhD - Publications

Affiliations: 
Tokyo University of Science, Japan 

64 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Hirano T, Tanidokoro K, Shimizu Y, Kawarabayasi Y, Ohshima T, Sato M, Tadano S, Ishikawa H, Takio S, Takechi K, Takano H. Moss Chloroplasts are Surrounded by a Peptidoglycan Wall Containing D-Amino Acids. The Plant Cell. PMID 27325639 DOI: 10.1105/tpc.16.00104  0.64
2015 Ishikawa H, Shiomi S. Alkaloid synthesis using chiral secondary amine organocatalysts. Organic & Biomolecular Chemistry. PMID 26625722 DOI: 10.1039/c5ob02021b  0.64
2015 Tadano S, Sugimachi Y, Sumimoto M, Tsukamoto S, Ishikawa H. Collective Synthesis and Biological Evaluation of Tryptophan-Based Dimeric Diketopiperazine Alkaloids. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 26598794 DOI: 10.1002/chem.201503417  0.64
2015 Shiomi S, Sugahara E, Ishikawa H. Efficient Organocatalytic Construction of C4-Alkyl Substituted Piperidines and Their Application to the Synthesis of (+)-α-Skytanthine. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 14758-63. PMID 26333476 DOI: 10.1002/chem.201503117  0.64
2015 Ishio A, Sasamura T, Ayukawa T, Kuroda J, Ishikawa HO, Aoyama N, Matsumoto K, Gushiken T, Okajima T, Yamakawa T, Matsuno K. O-fucose monosaccharide of Drosophila Notch has a temperature-sensitive function and cooperates with O-glucose glycan in Notch transport and Notch signaling activation. The Journal of Biological Chemistry. 290: 505-19. PMID 25378397 DOI: 10.1074/jbc.M114.616847  0.52
2015 Taniguchi T, Kurihara S, Tateishi H, Hatakeyama K, Koinuma M, Yokoi H, Hara M, Ishikawa H, Matsumoto Y. PH-driven, reversible epoxy ring opening/closing in graphene oxide Carbon. 84: 560-566. DOI: 10.1016/j.carbon.2014.12.054  0.64
2015 Ishikawa H. Total synthesis of biologically active alkaloids using bio-inspired indole oxidation Yakugaku Zasshi. 135: 383-393.  0.64
2014 Tadano S, Ishikawa H. Synthesis of tryptophan-based dimeric diketopiperazine alkaloids using bioinspired reactions Synlett. 25: 157-162. DOI: 10.1055/s-0033-1340160  0.64
2013 Mukaiyama T, Ishikawa H, Koshino H, Hayashi Y. One-pot synthesis of (-)-oseltamivir and mechanistic insights into the organocatalyzed Michael reaction Chemistry - a European Journal. 19: 17789-17800. PMID 24249709 DOI: 10.1002/chem.201302371  0.64
2013 Tadano S, Mukaeda Y, Ishikawa H. Bio-inspired dimerization reaction of tryptophan derivatives in aqueous acidic media: three-step syntheses of (+)-WIN 64821, (-)-ditryptophenaline, and (+)-naseseazine B. Angewandte Chemie (International Ed. in English). 52: 7990-4. PMID 23788445 DOI: 10.1002/anie.201303143  0.64
2013 Hayashi Y, Itoh T, Ishikawa H. Organocatalyst-mediated dehydrogenation of aldehydes to α,β-unsaturated aldehydes, and oxidative and enantioselective reaction of aldehydes and nitromethane catalyzed by diphenylprolinol silyl ether Advanced Synthesis and Catalysis. 355: 3661-3669. DOI: 10.1002/adsc.201300919  0.64
2013 Ishikawa H, Hayashi Y. Total Synthesis of Oseltamivir and ABT-341 Using One-Pot Technology Asymmetric Synthesis Ii: More Methods and Applications. 61-66. DOI: 10.1002/9783527652235.ch9  0.64
2012 Hayashi Y, Yasui Y, Kojima M, Kawamura T, Ishikawa H. Diarylprolinol in an asymmetric aldol reaction of an α-alkyl-α-oxo aldehyde as an electrophile. Chemical Communications (Cambridge, England). 48: 4570-2. PMID 22466901 DOI: 10.1039/c2cc31230a  0.64
2011 Hayashi Y, Gotoh H, Honma M, Sankar K, Kumar I, Ishikawa H, Konno K, Yui H, Tsuzuki S, Uchimaru T. Organocatalytic, enantioselective intramolecular [6+2] cycloaddition reaction for the formation of tricyclopentanoids and insight on its mechanism from a computational study. Journal of the American Chemical Society. 133: 20175-85. PMID 22050305 DOI: 10.1021/ja108516b  0.64
2011 Hayashi Y, Urushima T, Sakamoto D, Torii K, Ishikawa H. One-pot synthesis of chiral aziridines by a domino reaction by using desulfonylative formation on the N-tosyl imine of chloroacetaldehyde with an asymmetric Mannich reaction as a key step. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 11715-8. PMID 21887838 DOI: 10.1002/chem.201101668  0.64
2011 Urushima T, Ishikawa H, Hayashi Y. Asymmetric Mannich reaction of imines derived from aliphatic and aromatic aldehydes catalyzed by diarylprolinol silyl ether. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 8273-6. PMID 21656864 DOI: 10.1002/chem.201101077  0.64
2011 Hayashi Y, Itoh T, Ishikawa H. Oxidative and enantioselective cross-coupling of aldehydes and nitromethane catalyzed by diphenylprolinol silyl ether. Angewandte Chemie (International Ed. in English). 50: 3920-4. PMID 21442692 DOI: 10.1002/anie.201006885  0.64
2011 Ishikawa H, Sawano S, Yasui Y, Shibata Y, Hayashi Y. Asymmetric one-pot four-component coupling reaction: synthesis of substituted tetrahydropyrans catalyzed by diphenylprolinol silyl ether. Angewandte Chemie (International Ed. in English). 50: 3774-9. PMID 21438102 DOI: 10.1002/anie.201005386  0.64
2011 Ishikawa H, Honma M, Hayashi Y. One-pot high-yielding synthesis of the DPP4-selective inhibitor ABT-341 by a four-component coupling mediated by a diphenylprolinol silyl ether. Angewandte Chemie (International Ed. in English). 50: 2824-7. PMID 21387497 DOI: 10.1002/anie.201006204  0.64
2011 Hayashi Y, Yasui Y, Kawamura T, Kojima M, Ishikawa H. One-pot synthesis of chiral α-substituted β,γ-epoxy aldehyde derivatives through an asymmetric aldol reaction of chloroacetaldehyde. Angewandte Chemie (International Ed. in English). 50: 2804-7. PMID 21387492 DOI: 10.1002/anie.201005577  0.64
2011 Haque MA, Ishikawa H, Nishino H. Spontaneous conversion of 3-alkyl-substituted 3-hydroperoxypyrrolidine-2,4- diones into 5-alkyl-5-hydroxyoxazolidin-4-ones Chemistry Letters. 40: 1349-1351. DOI: 10.1246/cl.2011.1349  0.64
2011 Hayashi Y, Yasui Y, Kawamura T, Kojima M, Ishikawa H. Diarylprolinol in the direct asymmetric aldol reaction of trifluoromethylacetaldehyde ethyl hemiacetal with aldehyde Synlett. 485-488. DOI: 10.1055/s-0030-1259543  0.64
2011 Patora-Komisarska K, Benohoud M, Ishikawa H, Seebach D, Hayashi Y. Organocatalyzed michael addition of aldehydes to nitro alkenes - Generally accepted mechanism revisited and revised Helvetica Chimica Acta. 94: 719-745. DOI: 10.1002/hlca.201100122  0.64
2011 Ishikawa H, Bondzic BP, Hayashi Y. Synthesis of (-)-oseltamivir by using a microreactor in the curtius rearrangement European Journal of Organic Chemistry. 6020-6031. DOI: 10.1002/ejoc.201100074  0.64
2010 Bondzic BP, Urushima T, Ishikawa H, Hayashi Y. Asymmetric epoxidation of α-substituted acroleins catalyzed by diphenylprolinol silyl ether. Organic Letters. 12: 5434-7. PMID 21049980 DOI: 10.1021/ol102269s  0.64
2010 Ishikawa H, Suzuki T, Orita H, Uchimaru T, Hayashi Y. High-yielding synthesis of the anti-influenza neuraminidase inhibitor (-)-oseltamivir by two "one-pot" sequences. Chemistry (Weinheim An Der Bergstrasse, Germany). 16: 12616-26. PMID 20859964 DOI: 10.1002/chem.201001108  0.64
2010 Urushima T, Sakamoto D, Ishikawa H, Hayashi Y. Enantio- and diastereoselective synthesis of piperidines by coupling of four components in a "one-pot" sequence involving diphenylprolinol silyl ether mediated Michael reaction. Organic Letters. 12: 4588-91. PMID 20853903 DOI: 10.1021/ol1018932  0.64
2010 Urushima T, Yasui Y, Ishikawa H, Hayashi Y. Polymeric ethyl glyoxylate in an asymmetric aldol reaction catalyzed by diarylprolinol. Organic Letters. 12: 2966-9. PMID 20527926 DOI: 10.1021/ol1009812  0.64
2010 Gotoh H, Ogino H, Ishikawa H, Hayashi Y. One-pot synthesis of chiral bicyclo[3.3.0]octatrienes using diphenylprolinol silyl ether-mediated ene-type reaction Tetrahedron. 66: 4894-4899. DOI: 10.1016/j.tet.2010.03.010  0.64
2009 Itoh T, Ishikawa H, Hayashi Y. Asymmetric aldol reaction of acetaldehyde and isatin derivatives for the total syntheses of ent-convolutamydine E and CPC-1 and a half fragment of madindoline A and B. Organic Letters. 11: 3854-7. PMID 19655732 DOI: 10.1021/ol901432a  0.64
2009 Hayashi Y, Sankar K, Ishikawa H, Nozawa Y, Mizoue K, Kakeya H. Total synthesis and determination of the absolute configuration of FD-838, a naturally occurring azaspirobicyclic product. Bioorganic & Medicinal Chemistry Letters. 19: 3863-5. PMID 19394824 DOI: 10.1016/j.bmcl.2009.03.154  0.64
2009 Ishikawa H, Colby DA, Seto S, Va P, Tam A, Kakei H, Rayl TJ, Hwang I, Boger DL. Total synthesis of vinblastine, vincristine, related natural products, and key structural analogues. Journal of the American Chemical Society. 131: 4904-16. PMID 19292450 DOI: 10.1021/ja809842b  0.64
2009 Ishikawa H, Suzuki T, Hayashi Y. High-yielding synthesis of the anti-influenza neuramidase inhibitor (-)-oseltamivir by three "one-pot" operations. Angewandte Chemie (International Ed. in English). 48: 1304-7. PMID 19123206 DOI: 10.1002/anie.200804883  0.64
2009 Hayashi Y, Obi K, Ohta Y, Okamura D, Ishikawa H. Diphenylprolinol silyl ether as a catalyst in an enantioselective, catalytic michael reaction for the formation of alpha,alpha-disubstituted alpha-amino acid derivatives. Chemistry, An Asian Journal. 4: 246-9. PMID 19065594 DOI: 10.1002/asia.200800394  0.64
2009 Hayashi Y, Toyoshima M, Gotoh H, Ishikawa H. Diphenylprolinol silyl ether catalysis in an asymmetric formal carbo [3 + 3] cycloaddition reaction via a domino Michael/Knoevenagel condensation. Organic Letters. 11: 45-8. PMID 19053718 DOI: 10.1021/ol802330h  0.64
2009 Ishikawa H, Boger DL. Total synthesis of vindoline and related alkaloids Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 67: 123-133.  0.64
2008 Hayashi Y, Samanta S, Itoh T, Ishikawa H. Asymmetric, catalytic, and direct self-aldol reaction of acetaldehyde catalyzed by diarylprolinol. Organic Letters. 10: 5581-3. PMID 19053723 DOI: 10.1021/ol802438u  0.64
2008 Hayashi Y, Okano T, Itoh T, Urushima T, Ishikawa H, Uchimaru T. Direct organocatalytic mannich reaction of acetaldehyde: an improved catalyst and mechanistic insight from a computational study. Angewandte Chemie (International Ed. in English). 47: 9053-8. PMID 18925603 DOI: 10.1002/anie.200802073  0.64
2008 Hayashi Y, Samanta S, Gotoh H, Ishikawa H. Asymmetric Diels-Alder reactions of alpha,beta-unsaturated aldehydes catalyzed by a diarylprolinol silyl ether salt in the presence of water. Angewandte Chemie (International Ed. in English). 47: 6634-7. PMID 18646029 DOI: 10.1002/anie.200801408  0.64
2008 Hayashi Y, Shoji M, Ishikawa H, Yamaguchi J, Tamura T, Imai H, Nishigaya Y, Takabe K, Kakeya H, Osada H. The asymmetric total synthesis of (+)-cytotrienin a, an ansamycin-type anticancer drug. Angewandte Chemie (International Ed. in English). 47: 6657-60. PMID 18646025 DOI: 10.1002/anie.200802079  0.64
2008 Hayashi Y, Itoh T, Ohkubo M, Ishikawa H. Asymmetric Michael reaction of acetaldehyde catalyzed by diphenylprolinol silyl ether. Angewandte Chemie (International Ed. in English). 47: 4722-4. PMID 18435523 DOI: 10.1002/anie.200801130  0.64
2008 Hayashi Y, Gotoh H, Masui R, Ishikawa H. Diphenylprolinol silyl ether as a catalyst in an enantioselective, catalytic, formal aza [3+3] cycloaddition reaction for the formation of enantioenriched piperidines. Angewandte Chemie (International Ed. in English). 47: 4012-5. PMID 18399556 DOI: 10.1002/anie.200800662  0.64
2008 Hazelard D, Ishikawa H, Hashizume D, Koshino H, Hayashi Y. Proline-mediated enantioselective construction of tetrahydropyrans via a domino aldol/acetalization reaction. Organic Letters. 10: 1445-8. PMID 18311993 DOI: 10.1021/ol8002223  0.64
2008 Hayashi Y, Itoh T, Aratake S, Ishikawa H. A diarylprolinol in an asymmetric, catalytic, and direct crossed-aldol reaction of acetaldehyde. Angewandte Chemie (International Ed. in English). 47: 2082-4. PMID 18264959 DOI: 10.1002/anie.200704870  0.64
2008 Ishikawa H, Colby DA, Boger DL. Direct coupling of catharanthine and vindoline to provide vinblastine: total synthesis of (+)- and ent-(-)-vinblastine. Journal of the American Chemical Society. 130: 420-1. PMID 18081297 DOI: 10.1021/ja078192m  0.64
2008 Hayashi Y, Itoh T, Nagae N, Ohkubo M, Ishikawa H. The effectiveness of proteinogenic amino acids in the asymmetric aldol reaction in DMSO and aqueous DMSO Synlett. 1565-1570. DOI: 10.1055/s2008-1077789  0.64
2007 Gotoh H, Ishikawa H, Hayashi Y. Diphenylprolinol silyl ether as catalyst of an asymmetric, catalytic, and direct Michael reaction of nitroalkanes with alpha,beta-unsaturated aldehydes. Organic Letters. 9: 5307-9. PMID 17997567 DOI: 10.1021/ol702545z  0.64
2007 Ishikawa H, Boger DL. Total synthesis of (-)- and ent-(+)-4-desacetoxy-5-desethylvindoline Heterocycles. 72: 95-102. DOI: 10.1002/CHIN.200739176  0.64
2006 Takayama H, Misawa K, Okada N, Ishikawa H, Kitajima M, Hatori Y, Murayama T, Wongseripipatana S, Tashima K, Matsumoto K, Horie S. New procedure to mask the 2,3-pi bond of the indole nucleus and its application to the preparation of potent opioid receptor agonists with a Corynanthe skeleton. Organic Letters. 8: 5705-8. PMID 17134252 DOI: 10.1021/ol062173k  0.64
2006 Ishikawa H, Elliott GI, Velcicky J, Choi Y, Boger DL. Total synthesis of (-)- and ent-(+)-vindoline and related alkaloids. Journal of the American Chemical Society. 128: 10596-612. PMID 16895428 DOI: 10.1021/ja061256t  0.64
2006 Elliott GI, Fuchs JR, Blagg BS, Ishikawa H, Tao H, Yuan ZQ, Boger DL. Intramolecular diels-alder/1,3-dipolar cycloaddition cascade of 1,3,4-oxadiazoles. Journal of the American Chemical Society. 128: 10589-95. PMID 16895427 DOI: 10.1021/ja0612549  0.64
2006 Elliott GI, Velcicky J, Ishikawa H, Li Y, Boger DL. Total synthesis of (-)- and ent-(+)-vindorosine: tandem intramolecular Diels-Alder/1,3-dipolar cycloaddition of 1,3,4-oxadiazoles. Angewandte Chemie (International Ed. in English). 45: 620-2. PMID 16355429 DOI: 10.1002/CHIN.200621193  0.64
2006 Matsumoto K, Takayama H, Ishikawa H, Aimi N, Ponglux D, Watanabe K, Horie S. Partial agonistic effect of 9-hydroxycorynantheidine on μ-opioid receptor in the guinea-pig ileum Life Sciences. 78: 2265-2271. PMID 16266723 DOI: 10.1016/j.lfs.2005.09.030  0.64
2005 Choi Y, Ishikawa H, Velcicky J, Elliott GI, Miller MM, Boger DL. Total synthesis of (-)- and ent-(+)-vindoline. Organic Letters. 7: 4539-42. PMID 16178578 DOI: 10.1002/chin.200607211  0.64
2005 Matsumoto K, Horie S, Takayama H, Ishikawa H, Aimi N, Ponglux D, Murayama T, Watanabe K. Antinociception, tolerance and withdrawal symptoms induced by 7-hydroxymitragynine, an alkaloid from the Thai medicinal herb Mitragyna speciosa Life Sciences. 78: 2-7. PMID 16169018 DOI: 10.1016/j.lfs.2004.10.086  0.64
2005 Horie S, Koyama F, Takayama H, Ishikawa H, Aimi N, Ponglux D, Matsumoto K, Murayama T. Indole alkaloids of a Thai medicinal herb, Mitragyna speciosa, that has opioid agonistic effect in guinea-pig ileum Planta Medica. 71: 231-236. PMID 15770543 DOI: 10.1055/s-2005-837822  0.64
2005 Yuan ZQ, Ishikawa H, Boger DL. Total synthesis of natural (+)- [corrected] and ent-(-)-4-desacetoxy-6,7-dihydrovindorosine [corrected] and natural and ent-minovine: oxadiazole tandem intramolecular Diels-Alder/1,3-dipolar cycloaddition reaction. Organic Letters. 7: 741-4. PMID 15704939 DOI: 10.1021/ol050017s  0.64
2004 Takayama H, Ishikawa H, Kitajima M, Aimi N, Aji BM. A new 9-methoxyyohimbine-type indole alkaloid from Mitragyna africanus Chemical and Pharmaceutical Bulletin. 52: 359-361. PMID 14993762 DOI: 10.1248/cpb.52.359  0.64
2004 Matsumoto K, Horie S, Ishikawa H, Takayama H, Aimi N, Ponglux D, Watanabe K. Antinociceptive effect of 7-hydroxymitragynine in mice: Discovery of an orally active opioid analgesic from the Thai medicinal herb Mitragyna speciosa Life Sciences. 74: 2143-2155. PMID 14969718 DOI: 10.1016/j.lfs.2003.09.054  0.64
2004 Ishikawa H, Kitajima M, Takayama H. m-chloroperbenzoic acid oxidation of corynanthe-type indole alkaloid, mitragynine, afforded unusual dimerization products Heterocycles. 63: 2597-2604.  0.64
2002 Takayama H, Ishikawa H, Kitajima M, Aimi N. Formation of an unusual dimeric compound by lead tetraacetate oxidation of a Corynanthe-type indole alkaloid, mitragynine Chemical and Pharmaceutical Bulletin. 50: 960-963. PMID 12130854 DOI: 10.1248/cpb.50.960  0.64
2002 Takayama H, Ishikawa H, Kurihara M, Kitajima M, Aimi N, Ponglux D, Koyama F, Matsumoto K, Moriyama T, Yamamoto LT, Watanabe K, Murayama T, Horie S. Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: Discovery of opioid agonists structurally different from other opioid ligands Journal of Medicinal Chemistry. 45: 1949-1956. PMID 11960505 DOI: 10.1021/jm010576e  0.64
2002 Ishikawa H, Takayama H, Aimi N. Dimerization of indole derivatives with hypervalent iodines(III): A new entry for the concise total synthesis of rac- and meso-chimonanthines Tetrahedron Letters. 43: 5637-5639. DOI: 10.1016/S0040-4039(02)01137-1  0.64
2001 Takayama H, Ishikawa H, Kurihara M, Kitajima M, Sakai SI, Aimi N, Seki H, Yamaguchi K, Said IM, Houghton PJ. Structure revision of mitragynaline, an indole alkaloid in Mitragyna speciosa Tetrahedron Letters. 42: 1741-1743. DOI: 10.1016/S0040-4039(01)00006-5  0.64
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