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Amanda J Kedaigle - Publications

Affiliations: 
Broad Institute of MIT and Harvard, USA 
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16 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Pigoni M, Uzquiano A, Paulsen B, Kedaigle A, Yang SM, Symvoulidis P, Adiconis X, Velasco S, Sartore R, Kim K, Tucewicz A, Tropp SY, Tsafou K, Jin X, Barrett L, et al. Cell-type specific defects in PTEN-mutant cortical organoids converge on abnormal circuit activity. Human Molecular Genetics. PMID 37384417 DOI: 10.1093/hmg/ddad107  0.748
2022 Uzquiano A, Kedaigle AJ, Pigoni M, Paulsen B, Adiconis X, Kim K, Faits T, Nagaraja S, Antón-Bolaños N, Gerhardinger C, Tucewicz A, Murray E, Jin X, Buenrostro J, Chen F, et al. Proper acquisition of cell class identity in organoids allows definition of fate specification programs of the human cerebral cortex. Cell. 185: 3770-3788.e27. PMID 36179669 DOI: 10.1016/j.cell.2022.09.010  0.75
2022 Paulsen B, Velasco S, Kedaigle AJ, Pigoni M, Quadrato G, Deo AJ, Adiconis X, Uzquiano A, Sartore R, Yang SM, Simmons SK, Symvoulidis P, Kim K, Tsafou K, Podury A, et al. Autism genes converge on asynchronous development of shared neuron classes. Nature. PMID 35110736 DOI: 10.1038/s41586-021-04358-6  0.7
2021 Akimov SS, Jiang M, Kedaigle AJ, Arbez N, Marque LO, Eddings CR, Ranum PT, Whelan E, Tang A, Wang R, DeVine LR, Talbot CC, Cole RN, Ratovitski T, Davidson BL, et al. Immortalized striatal precursor neurons from Huntington's disease patient-derived iPS cells as a platform for target identification and screening for experimental therapeutics. Human Molecular Genetics. PMID 34296279 DOI: 10.1093/hmg/ddab200  0.625
2020 Ding J, Adiconis X, Simmons SK, Kowalczyk MS, Hession CC, Marjanovic ND, Hughes TK, Wadsworth MH, Burks T, Nguyen LT, Kwon JYH, Barak B, Ge W, Kedaigle AJ, Carroll S, et al. Author Correction: Systematic comparison of single-cell and single-nucleus RNA-sequencing methods. Nature Biotechnology. PMID 32341567 DOI: 10.1038/S41587-020-0534-Z  0.547
2020 Ding J, Adiconis X, Simmons SK, Kowalczyk MS, Hession CC, Marjanovic ND, Hughes TK, Wadsworth MH, Burks T, Nguyen LT, Kwon JYH, Barak B, Ge W, Kedaigle AJ, Carroll S, et al. Systematic comparison of single-cell and single-nucleus RNA-sequencing methods. Nature Biotechnology. PMID 32341560 DOI: 10.1038/S41587-020-0465-8  0.59
2019 Kedaigle AJ, Reidling JC, Lim RG, Adam M, Wu J, Wassie B, Stocksdale JT, Casale MS, Fraenkel E, Thompson LM. Treatment with JQ1, a BET bromodomain inhibitor, is selectively detrimental to R6/2 Huntington's disease mice. Human Molecular Genetics. PMID 31696228 DOI: 10.1093/Hmg/Ddz264  0.564
2019 Velasco S, Kedaigle AJ, Simmons SK, Nash A, Rocha M, Quadrato G, Paulsen B, Nguyen L, Adiconis X, Regev A, Levin JZ, Arlotta P. Individual brain organoids reproducibly form cell diversity of the human cerebral cortex. Nature. PMID 31168097 DOI: 10.1038/S41586-019-1289-X  0.699
2019 Zonouzi M, Berger D, Jokhi V, Kedaigle A, Lichtman J, Arlotta P. Individual Oligodendrocytes Show Bias for Inhibitory Axons in the Neocortex. Cell Reports. 27: 2799-2808.e3. PMID 31167127 DOI: 10.1016/j.celrep.2019.05.018  0.534
2019 Kedaigle AJ, Fraenkel E, Atwal RS, Wu M, Gusella JF, MacDonald ME, Kaye JA, Finkbeiner S, Mattis VB, Tom CM, Svendsen C, King AR, Chen Y, Stocksdale JT, Lim RG, et al. Bioenergetic deficits in Huntington's disease iPSC-derived neural cells and rescue with glycolytic metabolites. Human Molecular Genetics. PMID 30768179 DOI: 10.1093/Hmg/Ddy430  0.633
2018 Kedaigle A, Fraenkel E. Turning omics data into therapeutic insights. Current Opinion in Pharmacology. 42: 95-101. PMID 30149217 DOI: 10.1016/J.Coph.2018.08.006  0.565
2018 Kedaigle AJ, Fraenkel E. Discovering Altered Regulation and Signaling Through Network-based Integration of Transcriptomic, Epigenomic, and Proteomic Tumor Data. Methods in Molecular Biology (Clifton, N.J.). 1711: 13-26. PMID 29344883 DOI: 10.1007/978-1-4939-7493-1_2  0.558
2017 Akhmedov M, Kedaigle A, Chong RE, Montemanni R, Bertoni F, Fraenkel E, Kwee I. PCSF: An R-package for network-based interpretation of high-throughput data. Plos Computational Biology. 13: e1005694. PMID 28759592 DOI: 10.1371/Journal.Pcbi.1005694  0.574
2017 Lim RG, Quan C, Reyes-Ortiz AM, Lutz SE, Kedaigle AJ, Gipson TA, Wu J, Vatine GD, Stocksdale J, Casale MS, Svendsen CN, Fraenkel E, Housman DE, Agalliu D, Thompson LM. Huntington's Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits. Cell Reports. 19: 1365-1377. PMID 28514657 DOI: 10.1016/J.Celrep.2017.04.021  0.626
2016 Tuncbag N, Gosline SJ, Kedaigle A, Soltis AR, Gitter A, Fraenkel E. Network-Based Interpretation of Diverse High-Throughput Datasets through the Omics Integrator Software Package. Plos Computational Biology. 12: e1004879. PMID 27096930 DOI: 10.1371/Journal.Pcbi.1004879  0.593
2015 Akamandisa M, Kedaigle AJ, Radhakrishnan ML, Peterman TK, Elmore DE. Investigating Sec14 Domain Lipid Binding using Structural Modeling Biophysical Journal. 108: 252a. DOI: 10.1016/J.Bpj.2014.11.1396  0.58
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