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Carmine Coscia - Related publications

1965-2014 Biochemistry and Molecular Biology Saint Louis University School of Medicine, St. Louis, MO, United States 
Opioid Biosynthesis and Mechanism of Action
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Mehr-Un-Nisa, Munawar MA, Rankin D, Hruby VJ, Porreca F, Lee YS. C-terminal modified Enkephalin-like tetrapeptides with enhanced affinities at the kappa opioid receptor and monoamine transporters. Bioorganic & Medicinal Chemistry. 51: 116509. PMID 34798381 DOI: 10.1016/j.bmc.2021.116509   
2021 Gopalakrishnan L, Chatterjee O, Ravishankar N, Suresh S, Raju R, Mahadevan A, Prasad TSK. Opioid receptors signaling network. Journal of Cell Communication and Signaling. PMID 34724150 DOI: 10.1007/s12079-021-00653-z   
2021 Liu S, Kang WJ, Abrimian A, Xu J, Cartegni L, Majumdar S, Hesketh P, Bekker A, Pan YX. Alternative Pre-mRNA Splicing of the Mu Opioid Receptor Gene, : Insight into Complex Mu Opioid Actions. Biomolecules. 11. PMID 34680158 DOI: 10.3390/biom11101525   
2021 Zamora JC, Smith HR, Jennings EM, Chavera TS, Kotipalli V, Jay A, Husbands SM, Disney A, Berg KA, Clarke WP. Long-term antagonism and allosteric regulation of mu opioid receptors by the novel ligand, methocinnamox. Pharmacology Research & Perspectives. 9: e00887. PMID 34713624 DOI: 10.1002/prp2.887   
2021 Dodu JC, Moncayo RK, Damaj MI, Schlosburg JE, Akbarali HI, O'Brien LD, Kendall DA, Lu D, Lichtman AH. The CB Receptor Positive Allosteric Modulator, ZCZ011, Attenuates Naloxone-Precipitated Diarrhea and Weight Loss in Oxycodone-Dependent Mice. The Journal of Pharmacology and Experimental Therapeutics. PMID 34625464 DOI: 10.1124/jpet.121.000723   
2021 Kong Q, Tian S, Ma C, Wang G, Zhang M. Cannabinoid Receptor Type 2 Agonist Reduces Morphine Tolerance via Mitogen Activated Protein Kinase Phosphatase Induction and Mitogen Activated Protein Kinase Dephosphorylation. Neuroscience. PMID 34774714 DOI: 10.1016/j.neuroscience.2021.11.007   
2021 Nozohouri S, Zhang Y, Albekairi TH, Vaidya B, Abbruscato TJ. . The Journal of Pharmacology and Experimental Therapeutics. PMID 34663677 DOI: 10.1124/jpet.121.000831   
2021 Zhang F, Chen X, Chen J, Xu Y, Li S, Guo Y, Pu X. Probing Allosteric Regulation Mechanism of W7.35 on Agonist-Induced Activity for μOR by Mutation Simulation. Journal of Chemical Information and Modeling. PMID 34779608 DOI: 10.1021/acs.jcim.1c00650   
2021 Mansour A, Nagi K, Dallaire P, Lukasheva V, Le Gouill C, Bouvier M, Pineyro G. Comprehensive Signaling Profiles Reveal Unsuspected Functional Selectivity of δ-Opioid Receptor Agonists and Allow the Identification of Ligands with the Greatest Potential for Inducing Cyclase Superactivation. Acs Pharmacology & Translational Science. 4: 1483-1498. PMID 34661070 DOI: 10.1021/acsptsci.1c00019   
2021 Gao J, Yuan X, Zheng X, Zhao X, Wang T, Liang Q, Xiao C, Wang J, Li Q, Zhao X. Two-point immobilization of a conformation-specific beta-adrenoceptor for recognizing the receptor agonists or antagonists inspired by binding-induced DNA assembly. Biomaterials Science. PMID 34704989 DOI: 10.1039/d1bm01222c   
2021 Mitra A, Sarkar A, Borics A. Universal Properties and Specificities of the β-Adrenergic Receptor-G Protein Complex Activation Mechanism Revealed by All-Atom Molecular Dynamics Simulations. International Journal of Molecular Sciences. 22. PMID 34638767 DOI: 10.3390/ijms221910423   
2021 Bailey AMJ, Li HO, Burns K, Cheng W, Collister D, Westby EP, Purdy KS, Walsh M, Tennankore KK. Targeting the Opioid Pathway for the Treatment of Chronic Kidney Disease Associated Pruritus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. The British Journal of Dermatology. PMID 34582571 DOI: 10.1111/bjd.20769   
2021 Turner RC, Gatson BJ, Hernandez JA, Alexander AB, Aitken-Palmer C, Vigani A, Heard DJ. Sedation and Anesthesia of Galapagos (), Aldabra (), and African Spurred Tortoises (): A Retrospective Review (2009-2019). Animals : An Open Access Journal From Mdpi. 11. PMID 34679940 DOI: 10.3390/ani11102920   
2021 García M, Llorente V, Garriga L, Christmann U, Rodríguez-Escrich S, Virgili M, Fernández B, Bordas M, Ayet E, Burgueño J, Pujol M, Dordal A, Portillo-Salido E, Gris G, Vela JM, et al. Propionamide Derivatives as Dual μ-Opioid Receptor Agonists and σ Receptor Antagonists for the Treatment of Pain. Journal of Medicinal Chemistry. 64: 10139-10154. PMID 34236190 DOI: 10.1021/acs.jmedchem.1c00417   
2021 Heyder NA, Kleinau G, Speck D, Schmidt A, Paisdzior S, Szczepek M, Bauer B, Koch A, Gallandi M, Kwiatkowski D, Bürger J, Mielke T, Beck-Sickinger AG, Hildebrand PW, Spahn CMT, et al. Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-α-MSH and setmelanotide. Cell Research. PMID 34561620 DOI: 10.1038/s41422-021-00569-8   
2021 Wang M, Hou S, Liu Y, Li D, Lin J. Identification of Novel Antagonists Targeting Cannabinoid Receptor 2 Using a Multi-Step Virtual Screening Strategy. Molecules (Basel, Switzerland). 26. PMID 34771087 DOI: 10.3390/molecules26216679   
2021 DiCello JJ, Carbone SE, Saito A, Pham V, Szymaszkiewicz A, Gondin AB, Alvi S, Marique K, Shenoy P, Veldhuis NA, Fichna J, Canals M, Christopoulos A, Valant C, Poole DP. Positive allosteric modulation of endogenous delta opioid receptor signaling in the enteric nervous system is a potential treatment for gut motility disorders. American Journal of Physiology. Gastrointestinal and Liver Physiology. PMID 34755545 DOI: 10.1152/ajpgi.00297.2021   
2021 Leo LM, Abood ME. CB1 Cannabinoid Receptor Signaling and Biased Signaling. Molecules (Basel, Switzerland). 26. PMID 34500853 DOI: 10.3390/molecules26175413   
2021 Liu T, Yi TL, Yang DQ, Tao YX. Regulation of melanocortin-5 receptor pharmacology by two isoforms of MRAP2 in ricefield eel (Monopterus albus). General and Comparative Endocrinology. 113928. PMID 34653433 DOI: 10.1016/j.ygcen.2021.113928   
2021 Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, et al. Structure, function and pharmacology of human itch GPCRs. Nature. PMID 34789874 DOI: 10.1038/s41586-021-04126-6   
2021 Ding G, Li D, Sun Y, Chen K, Song D. -Opioid Receptor Agonist Ameliorates Postoperative Neurocognitive Disorder by Activating the Ca/CaMKII/CREB Pathway. Journal of Healthcare Engineering. 2021: 3401654. PMID 34608407 DOI: 10.1155/2021/3401654   
2021 Wolf P, Mohr A, Gavins G, Behr V, Mörl K, Seitz O, Beck-Sickinger AG. Orthogonal Peptide-Templated Labeling Elucidates Lateral ET R/ET R Proximity and Reveals Altered Downstream Signaling. Chembiochem : a European Journal of Chemical Biology. PMID 34699123 DOI: 10.1002/cbic.202100340   
2021 Matsushita Y, Manabe M, Kitagawa I, Higuchi M, Hosaka YZ, Kitamura N. Inhibition of transient receptor potential vanilloid type 1 through α adrenergic receptors at peripheral nerve terminals relieves pain. The Journal of Veterinary Medical Science. 83: 1570-1581. PMID 34470979 DOI: 10.1292/jvms.21-0429   
2021 Khan SA, Zia K, Ashraf S, Khan A, Ul-Haq Z. Theoretical investigation of selective ligand binding mode of galanin receptors. Journal of Biomolecular Structure & Dynamics. 1-11. PMID 34632940 DOI: 10.1080/07391102.2021.1977703   
2021 Wookey P, Gupta P, Bittencourt L, Cheung S, Hare D, Furness S. Methods to measure calcitonin receptor activity, up-regulated in cell stress, apoptosis and autophagy. F1000research. 10: 1019. PMID 34745567 DOI: 10.12688/f1000research.72845.1   
2021 Lou L, Li C, Wang J, Wu A, Zhang T, Ma Z, Chai L, Zhang D, Zhao Y, Nie B, Jin Q, Chen H, Liu WJ. Yiqi Huoxue preserves heart function by upregulating the Sigma-1 receptor in rats with myocardial infarction. Experimental and Therapeutic Medicine. 22: 1308. PMID 34630662 DOI: 10.3892/etm.2021.10743   
2021 Duan LL, Qiu XY, Wei SQ, Su HY, Bai FR, Traub RJ, Zhou Q, Cao DY. Spinal CCK contributes to somatic hyperalgesia induced by orofacial inflammation combined with stress in adult female rats. European Journal of Pharmacology. 174619. PMID 34748768 DOI: 10.1016/j.ejphar.2021.174619   
2021 Shinde AK, Badange RK, Reballi V, Achanta PK, Bojja K, Manchineella S, Rao Muddana N, Subramanian R, Choudary Palacharla R, Benade V, Jayarajan P, Thentu JB, Lingavarapu BB, Yarra S, Kagita N, et al. 1-[2-(1-Cyclobutylpiperidin-4-yloxy)-6,7-dihydro-4H-thiazolo[5,4-c]pyridin-5-yl]propan-1-one: a Histamine H Receptor Inverse Agonist with Efficacy in Animal Models of Cognition. Chemmedchem. PMID 34761873 DOI: 10.1002/cmdc.202100583   
2021 Steindorf D, Loeuillet A, Bagnard D, Strand S, Schneider D. Increased stability of the TM helix oligomer abrogates the apoptotic activity of the human Fas receptor. Biochimica Et Biophysica Acta. Biomembranes. 1864: 183807. PMID 34662567 DOI: 10.1016/j.bbamem.2021.183807   
2021 Howlett AC, Thomas BF, Huffman JW. The Spicy Story of Cannabimimetic Indoles. Molecules (Basel, Switzerland). 26. PMID 34684770 DOI: 10.3390/molecules26206190   
2021 Faúndez-Parraguez M, Alarcón-Miranda C, Cho YH, Pessoa-Mahana H, Gallardo-Garrido C, Chung H, Faúndez M, Pessoa-Mahana D. New Pyridone-Based Derivatives as Cannabinoid Receptor Type 2 Agonists. International Journal of Molecular Sciences. 22. PMID 34681877 DOI: 10.3390/ijms222011212   
2021 Ishida A, Okabe Y, Matsushita T, Sekiguchi T, Nishio T, Komagata T, Iwaki M, Miyata H, Katagi J, Naganawa A, Maruyama T, Imagawa A. Design, synthesis, and biological evaluation of novel somatostatin receptor subtype-2 agonists: Optimization for potency and risk mitigation of hERG and phospholipidosis. Bioorganic & Medicinal Chemistry. 49: 116424. PMID 34626901 DOI: 10.1016/j.bmc.2021.116424   
2021 Chakraborty S, Uprety R, Slocum ST, Irie T, Le Rouzic V, Li X, Wilson LL, Scouller B, Alder AF, Kruegel AC, Ansonoff M, Varadi A, Eans SO, Hunkele A, Allaoa A, et al. Oxidative Metabolism as a Modulator of Kratom's Biological Actions. Journal of Medicinal Chemistry. PMID 34783240 DOI: 10.1021/acs.jmedchem.1c01111   
2021 Buwaneka P, Ralko A, Gorai S, Pham H, Cho W. Phosphoinositide binding activity of Smad2 is essential for its function in TGF-β signaling. The Journal of Biological Chemistry. 101303. PMID 34655614 DOI: 10.1016/j.jbc.2021.101303   
2021 Suresh M, Li B, Huang X, Korolowicz KE, Murreddu MG, Gudima SO, Menne S. Agonistic Activation of Cytosolic DNA Sensing Receptors in Woodchuck Hepatocyte Cultures and Liver for Inducing Antiviral Effects. Frontiers in Immunology. 12: 745802. PMID 34671360 DOI: 10.3389/fimmu.2021.745802   
2021 Lee S. Development of High Affinity Calcitonin Analog Fragments Targeting Extracellular Domains of Calcitonin Family Receptors. Biomolecules. 11. PMID 34572577 DOI: 10.3390/biom11091364   
2021 Okita K, Kato K, Shigemoto Y, Sato N, Matsumoto T, Matsuda H. Effects of an Adenosine A Receptor Antagonist on Striatal Dopamine D2-Type Receptor Availability: A Randomized Control Study Using Positron Emission Tomography. Frontiers in Neuroscience. 15: 729153. PMID 34588952 DOI: 10.3389/fnins.2021.729153   
2021 Biswas AD, Catte A, Mancini G, Barone V. Analysis of L-DOPA and Droxidopa binding to Human β-Adrenergic Receptor. Biophysical Journal. PMID 34767786 DOI: 10.1016/j.bpj.2021.11.007   
2021 Patberg M, Isaak A, Füsser F, Ortiz Zacarías NV, Vinnenberg L, Schulte J, Michetti L, Grey L, van der Horst C, Hundehege P, Koch O, Heitman LH, Budde T, Junker A. Piperazine squaric acid diamides, a novel class of allosteric P2X7 receptor antagonists. European Journal of Medicinal Chemistry. 226: 113838. PMID 34571173 DOI: 10.1016/j.ejmech.2021.113838   
2021 Gysel K, Laursen M, Thygesen MB, Lironi D, Bozsóki Z, Hjuler CT, Maolanon NN, Cheng J, Bjørk PK, Vinther M, Madsen LH, Rübsam H, Muszyński A, Ghodrati A, Azadi P, et al. Kinetic proofreading of lipochitooligosaccharides determines signal activation of symbiotic plant receptors. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34716271 DOI: 10.1073/pnas.2111031118   
2021 Wines BD, Trist HM, Esparon S, Impey RE, Mackay GA, Andrews RK, Soares da Costa TP, Pietersz GA, Baker RI, Hogarth PM. Fc Binding by FcγRIIa Is Essential for Cellular Activation by the Anti-FcγRIIa mAbs 8.26 and 8.2. Frontiers in Immunology. 12: 666813. PMID 34759915 DOI: 10.3389/fimmu.2021.666813   
2021 Denys IB, Gao J, Sutphen JC, Zaveri NT, Kapusta DR. Cardiovascular and renal effects of novel non-peptide nociceptin opioid peptide (NOP) receptor agonists. British Journal of Pharmacology. PMID 34705263 DOI: 10.1111/bph.15717   
2021 Rivera R, Williams NA, Kennedy GG, Sánchez-Pavón P, Chun J. Generation of an Lpar1-EGFP Fusion Knock-in Transgenic Mouse Line. Cell Biochemistry and Biophysics. 79: 619-627. PMID 34652685 DOI: 10.1007/s12013-021-01033-5   
2021 Fouad Shalaby MA, Abd El Latif HA, El Yamani M, Galal MA, Kamal S, Sindi I, Masaood R. Therapeutic activity of sarpogrelate and dopamine D receptor agonists on cardiovascular and renal systems in rats with alloxan-induced diabetes. Bmc Pharmacology & Toxicology. 22: 64. PMID 34702339 DOI: 10.1186/s40360-021-00526-6   
2021 Connelly SM, Sridharan R, Naider F, Dumont ME. Oligomerization of Yeast α-factor Receptor Detected by Fluorescent Energy Transfer Between Ligands. Biophysical Journal. PMID 34627767 DOI: 10.1016/j.bpj.2021.10.005   
2021 Hoglin BE, Miner M, Dores RM. Pharmacological properties of whale shark (Rhincodon typus) melanocortin-2 receptor and melancortin-5 receptor: Interaction with MRAP1 and MRAP2. General and Comparative Endocrinology. 113915. PMID 34607718 DOI: 10.1016/j.ygcen.2021.113915   
2021 Zarkin A, Jahan R, Uprety R, Zhang Y, McElhinny C, Snyder R, Gay E, Jewula G, Bool H, Clark SD, Runyon S. Identification of a Novel Neuropeptide S Receptor Antagonist Scaffold Based on the SHA-68 Core. Pharmaceuticals (Basel, Switzerland). 14. PMID 34681248 DOI: 10.3390/ph14101024   
2021 Cai X, Yao Y, Teng F, Li Y, Wu L, Yan W, Lin N. The role of P2X7 receptor in infection and metabolism: Based on inflammation and immunity. International Immunopharmacology. 101: 108297. PMID 34717202 DOI: 10.1016/j.intimp.2021.108297   
2021 Mann G, Kadiyala KG, Thirumal M, Tiwari AK, Datta A. Receptor mapping using methoxy phenyl piperazine derivative: Preclinical PET imaging. Bioorganic Chemistry. 117: 105429. PMID 34736134 DOI: 10.1016/j.bioorg.2021.105429   
2021 Lukin A, Bakholdina A, Chudinov M, Onopchenko O, Zhuravel E, Zozulya S, Gureev M, Krasavin M. Strained contacts with the cell membrane may influence ligand affinity to G protein coupled receptors: a case of free fatty acid receptor 1 agonists. Journal of Enzyme Inhibition and Medicinal Chemistry. 36: 1651-1658. PMID 34294008 DOI: 10.1080/14756366.2021.1955874