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Roberto A. Chica, Ph.D. - Publications

Affiliations: 
University of Ottawa, Ottawa, ON, Canada 
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34 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Rakotoharisoa RV, Seifinoferest B, Zarifi N, Miller JDM, Rodriguez JM, Thompson MC, Chica RA. Design of efficient artificial enzymes using crystallographically-enhanced conformational sampling. Biorxiv : the Preprint Server For Biology. PMID 37961474 DOI: 10.1101/2023.11.01.564846  0.417
2023 St-Jacques AD, Rodriguez JM, Eason MG, Foster SM, Khan ST, Damry AM, Goto NK, Thompson MC, Chica RA. Computational remodeling of an enzyme conformational landscape for altered substrate selectivity. Nature Communications. 14: 6058. PMID 37770431 DOI: 10.1038/s41467-023-41762-0  0.371
2020 Chica RA. Protein Engineering, Design and Selection. Protein Engineering, Design & Selection : Peds. 33. PMID 33094336 DOI: 10.1093/protein/gzaa024  0.31
2020 Broom A, Rakotoharisoa RV, Thompson MC, Zarifi N, Nguyen E, Mukhametzhanov N, Liu L, Fraser JS, Chica RA. Ensemble-based enzyme design can recapitulate the effects of laboratory directed evolution in silico. Nature Communications. 11: 4808. PMID 32968058 DOI: 10.1038/s41467-020-18619-x  0.418
2019 Wang CY, Chang PM, Ary ML, Allen BD, Chica RA, Mayo SL, Olafson BD. ProtaBank: A repository for protein design and engineering data. Protein Science : a Publication of the Protein Society. 28: 672. PMID 30747468 DOI: 10.1002/pro.3585  0.681
2019 Damry AM, Mayer MM, Goto NK, Chica RA. Solution NMR Structure of DANCER3-F34A, a rigid and natively folded single mutant of the dynamic protein DANCER-3 Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb6Njf/Pdb  0.322
2019 St-Jacques AD, Eyahpaise MC, Chica RA. Computational Design of Multisubstrate Enzyme Specificity Acs Catalysis. 9: 5480-5485. DOI: 10.1021/Acscatal.9B01464  0.536
2018 Walton CJ, Thiebaut F, Brunzelle JS, Couture JF, Chica RA. Structural determinants of the stereo-inverting activity of Pseudomonas stutzeri D-phenylglycine aminotransferase. Biochemistry. PMID 30153007 DOI: 10.1021/Acs.Biochem.8B00767  0.393
2018 Wang CY, Chang PM, Ary ML, Allen BD, Chica RA, Mayo SL, Olafson BD. ProtaBank: A repository for protein design and engineering data. Protein Science : a Publication of the Protein Society. PMID 29575358 DOI: 10.1002/Pro.3406  0.683
2017 Davey JA, Damry AM, Goto NK, Chica RA. Rational design of proteins that exchange on functional timescales. Nature Chemical Biology. PMID 29058725 DOI: 10.1038/Nchembio.2503  0.448
2017 Davey JA, Chica RA. Multistate Computational Protein Design with Backbone Ensembles. Methods in Molecular Biology (Clifton, N.J.). 1529: 161-179. PMID 27914050 DOI: 10.1007/978-1-4939-6637-0_7  0.452
2016 Eason MG, Damry AM, Chica RA. Structure-guided rational design of red fluorescent proteins: towards designer genetically-encoded fluorophores. Current Opinion in Structural Biology. 45: 91-99. PMID 28038355 DOI: 10.1016/J.Sbi.2016.12.001  0.448
2016 Davey JA, Chica RA. Turning a Negative into a Positive: Conversion of a Homodimer into a Heterodimer Using Negative State Repertoires. Structure (London, England : 1993). 24: 496-7. PMID 27050684 DOI: 10.1016/J.Str.2016.03.012  0.329
2016 St-Jacques AD, Rachel NM, Curry DR, Gillet SMFG, Clouthier CM, Keillor JW, Pelletier JN, Chica RA. Specificity of transglutaminase-catalyzed peptide synthesis Journal of Molecular Catalysis B: Enzymatic. 123: 53-61. DOI: 10.1016/J.Molcatb.2015.11.009  0.626
2015 Pandelieva AT, Baran MJ, Calderini GF, McCann JL, Tremblay V, Sarvan S, Davey JA, Couture JF, Chica RA. Brighter Red Fluorescent Proteins by Rational Design of Triple-Decker Motif. Acs Chemical Biology. PMID 26697759 DOI: 10.1021/Acschembio.5B00774  0.351
2015 Davey JA, Damry AM, Euler CK, Goto NK, Chica RA. Prediction of Stable Globular Proteins Using Negative Design with Non-native Backbone Ensembles. Structure (London, England : 1993). 23: 2011-21. PMID 26412333 DOI: 10.1016/J.Str.2015.07.021  0.422
2015 Chica RA. Protein engineering in the 21st century. Protein Science : a Publication of the Protein Society. 24: 431-3. PMID 25644972 DOI: 10.1002/Pro.2656  0.393
2015 Lanouette S, Davey JA, Elisma F, Ning Z, Figeys D, Chica RA, Couture JF. Discovery of substrates for a SET domain lysine methyltransferase predicted by multistate computational protein design. Structure (London, England : 1993). 23: 206-15. PMID 25533488 DOI: 10.1016/J.Str.2014.11.004  0.459
2015 Davey JA, Chica RA. Optimization of rotamers prior to template minimization improves stability predictions made by computational protein design. Protein Science : a Publication of the Protein Society. 24: 545-60. PMID 25492709 DOI: 10.1002/Pro.2618  0.339
2014 Barber JE, Damry AM, Calderini GF, Walton CJ, Chica RA. Continuous colorimetric screening assay for detection of d-amino acid aminotransferase mutants displaying altered substrate specificity. Analytical Biochemistry. 463: 23-30. PMID 24949900 DOI: 10.1016/J.Ab.2014.06.006  0.346
2014 Davey JA, Chica RA. Improving the accuracy of protein stability predictions with multistate design using a variety of backbone ensembles Proteins: Structure, Function and Bioinformatics. 82: 771-784. PMID 24174277 DOI: 10.1002/Prot.24457  0.391
2013 Mironov GG, St-Jacques AD, Mungham A, Eason MG, Chica RA, Berezovski MV. Bioanalysis for biocatalysis: Multiplexed capillary electrophoresis-mass spectrometry assay for aminotransferase substrate discovery and specificity profiling Journal of the American Chemical Society. 135: 13728-13736. PMID 23964747 DOI: 10.1021/Ja407486Z  0.359
2013 Walton CJ, Chica RA. A high-throughput assay for screening L- or D-amino acid specific aminotransferase mutant libraries. Analytical Biochemistry. 441: 190-8. PMID 23871995 DOI: 10.1016/J.Ab.2013.07.004  0.374
2012 Moore MM, Oteng-Pabi SK, Pandelieva AT, Mayo SL, Chica RA. Recovery of red fluorescent protein chromophore maturation deficiency through rational design. Plos One. 7: e52463. PMID 23285050 DOI: 10.1371/Journal.Pone.0052463  0.617
2012 Davey JA, Chica RA. Multistate approaches in computational protein design Protein Science. 21: 1241-1252. PMID 22811394 DOI: 10.1002/Pro.2128  0.481
2012 Privett HK, Kiss G, Lee TM, Blomberg R, Chica RA, Thomas LM, Hilvert D, Houk KN, Mayo SL. Iterative approach to computational enzyme design. Proceedings of the National Academy of Sciences of the United States of America. 109: 3790-5. PMID 22357762 DOI: 10.1073/Pnas.1118082108  0.682
2012 Hemmert AC, Otto TC, Chica RA, Wierdl M, Edwards JS, Lewis SM, Edwards CC, Tsurkan L, Cadieux CL, Kasten SA, Cashman JR, Mayo SL, Potter PM, Cerasoli DM, Redinbo MR. Correction: Nerve Agent Hydrolysis Activity Designed into a Human Drug Metabolism Enzyme Plos One. 7. DOI: 10.1371/Annotation/C5953F27-95F8-4A1B-A46C-639D90E182Ac  0.595
2011 Hemmert AC, Otto TC, Chica RA, Wierdl M, Edwards JS, Lewis SM, Lewis SL, Edwards CC, Tsurkan L, Cadieux CL, Kasten SA, Cashman JR, Mayo SL, Potter PM, Cerasoli DM, et al. Nerve agent hydrolysis activity designed into a human drug metabolism enzyme. Plos One. 6: e17441. PMID 21445272 DOI: 10.1371/Journal.Pone.0017441  0.627
2010 Chica RA, Moore MM, Allen BD, Mayo SL. Generation of longer emission wavelength red fluorescent proteins using computationally designed libraries. Proceedings of the National Academy of Sciences of the United States of America. 107: 20257-62. PMID 21059931 DOI: 10.1073/Pnas.1013910107  0.682
2009 Pardin C, Roy I, Chica RA, Bonneil E, Thibault P, Lubell WD, Pelletier JN, Keillor JW. Photolabeling of tissue transglutaminase reveals the binding mode of potent cinnamoyl inhibitors Biochemistry. 48: 3346-3353. PMID 19271761 DOI: 10.1021/Bi802021C  0.621
2008 Keillor JW, Chica RA, Chabot N, Vinci V, Pardin C, Fortin E, Gillet SMFG, Nakano Y, Kaartinen MT, Pelletier JN, Lubell WD. The bioorganic chemistry of transglutaminase - from mechanism to inhibition and engineering Canadian Journal of Chemistry. 86: 271-276. DOI: 10.1139/V08-024  0.649
2005 Chica RA, Doucet N, Pelletier JN. Semi-rational approaches to engineering enzyme activity: Combining the benefits of directed evolution and rational design Current Opinion in Biotechnology. 16: 378-384. PMID 15994074 DOI: 10.1016/J.Copbio.2005.06.004  0.741
2004 Chica RA, Gagnon P, Keillor JW, Pelletier JN. Tissue transglutaminase acylation: Proposed role of conserved active site Tyr and Trp residues revealed by molecular modeling of peptide substrate binding Protein Science. 13: 979-991. PMID 15010546 DOI: 10.1110/Ps.03433304  0.628
2004 Gillet SMFG, Chica RA, Keillor JW, Pelletier JN. Expression and rapid purification of highly active hexahistidine-tagged guinea pig liver transglutaminase Protein Expression and Purification. 33: 256-264. PMID 14711514 DOI: 10.1016/J.Pep.2003.10.003  0.617
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