57 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Tran TTQ, Narayanan C, Loes AN, Click TH, Pham NTH, Létourneau M, Harms MJ, Calmettes C, Agarwal PK, Doucet N. Ancestral sequence reconstruction dissects structural and functional differences among eosinophil ribonucleases. The Journal of Biological Chemistry. 107280. PMID 38588810 DOI: 10.1016/j.jbc.2024.107280  0.356
2023 Bernard DN, Narayanan C, Hempel T, Bafna K, Bhojane PP, Létourneau M, Howell EE, Agarwal PK, Doucet N. Conformational exchange divergence along the evolutionary pathway of eosinophil-associated ribonucleases. Structure (London, England : 1993). PMID 36649708 DOI: 10.1016/j.str.2022.12.011  0.787
2023 Lemay-St-Denis C, Alejaldre L, Jemouai Z, Lafontaine K, St-Aubin M, Hitache K, Valikhani D, Weerasinghe NW, Létourneau M, Thibodeaux CJ, Doucet N, Baron C, Copp JN, Pelletier JN. A conserved SH3-like fold in diverse putative proteins tetramerizes into an oxidoreductase providing an antimicrobial resistance phenotype. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 378: 20220040. PMID 36633286 DOI: 10.1098/rstb.2022.0040  0.664
2022 Lemay-St-Denis C, Doucet N, Pelletier JN. Integrating dynamics into enzyme engineering. Protein Engineering, Design & Selection : Peds. PMID 36416215 DOI: 10.1093/protein/gzac015  0.642
2021 Pham NTH, Létourneau M, Fortier M, Bégin G, Al-Abdul-Wahid MS, Pucci F, Folch B, Rooman M, Chatenet D, St-Pierre Y, Lagüe P, Calmettes C, Doucet N. Perturbing dimer interactions and allosteric communication modulates the immunosuppressive activity of human galectin-7. The Journal of Biological Chemistry. 297: 101308. PMID 34673030 DOI: 10.1016/j.jbc.2021.101308  0.306
2020 Agarwal PK, Bernard DN, Bafna K, Doucet N. Enzyme dynamics: Looking beyond a single structure. Chemcatchem. 12: 4704-4720. PMID 33897908 DOI: 10.1002/Cctc.202000665  0.489
2020 Rueda AM, López de Los Santos Y, Vincent AT, Létourneau M, Hernández I, Sánchez CI, Molina V D, Ospina SA, Veyrier FJ, Doucet N. Genome sequencing and functional characterization of a Dictyopanus pusillus fungal enzymatic extract offers a promising alternative for lignocellulose pretreatment of oil palm residues. Plos One. 15: e0227529. PMID 32730337 DOI: 10.1371/Journal.Pone.0227529  0.317
2020 Narayanan C, Bernard DN, Letourneau M, Gagnon J, Gagné D, Bafna K, Calmettes C, Couture JF, Agarwal PK, Doucet N. Insights into structural and dynamical changes experienced by human RNase 6 upon ligand binding. Biochemistry. PMID 31909602 DOI: 10.1021/Acs.Biochem.9B00888  0.823
2019 Santos YLL, Chew-Fajardo YL, Brault G, Doucet N. Dissecting the evolvability landscape of the CalB active site toward aromatic substrates. Scientific Reports. 9: 15588. PMID 31666622 DOI: 10.1038/S41598-019-51940-0  0.425
2019 Bafna K, Narayanan C, Chennubhotla SC, Doucet N, Agarwal PK. Nucleotide substrate binding characterization in human pancreatic-type ribonucleases. Plos One. 14: e0220037. PMID 31393891 DOI: 10.1371/Journal.Pone.0220037  0.791
2019 Antunes VU, Llontop E, Vasconcelos FNDC, L Oacute Pez de Los Santos Y, Oliveira RJ, Lincopan N, Farah CS, Doucet N, Mittermaier AK, Favaro DC. Importance of the β5-β6 Loop for the Structure, Catalytic Efficiency, and Stability of the Carbapenem-Hydrolyzing Class D β-lactamase Subfamily OXA-143. Biochemistry. PMID 31355630 DOI: 10.1021/Acs.Biochem.9B00365  0.376
2019 Dulcey CE, López de Los Santos Y, Létourneau M, Déziel E, Doucet N. Semi-rational evolution of the 3-(3-hydroxyalkanoyloxy)alkanoate (HAA) synthase RhlA to improve rhamnolipid production in Pseudomonas aeruginosa and Burkholderia glumae. The Febs Journal. PMID 31177633 DOI: 10.1111/Febs.14954  0.44
2019 Gobeil SMC, Ebert MCCJC, Park J, Gagné D, Doucet N, Berghuis AM, Pleiss J, Pelletier JN. The Structural Dynamics of Engineered β-Lactamases Vary Broadly on Three Timescales yet Sustain Native Function. Scientific Reports. 9: 6656. PMID 31040324 DOI: 10.1038/S41598-019-42866-8  0.797
2018 Debbabi S, Groleau MC, Létourneau M, Narayanan C, Gosselin LL, Iddir M, Gagnon J, Doucet N, Déziel E, Chatenet D. Antibacterial properties of the pituitary adenylate cyclase-activating polypeptide: A new human antimicrobial peptide. Plos One. 13: e0207366. PMID 30462698 DOI: 10.1371/Journal.Pone.0207366  0.739
2018 Gagné D, Narayanan C, Bafna K, Charest LA, Agarwal PK, Doucet N. Correction to: Sequence-specific backbone resonance assignments and microsecond timescale molecular dynamics simulation of human eosinophil-derived neurotoxin. Biomolecular Nmr Assignments. PMID 30083869 DOI: 10.1007/s12104-018-9833-4  0.77
2018 Narayanan C, Bernard DN, Bafna K, Gagné D, Agarwal PK, Doucet N. Ligand-Induced Variations in Structural and Dynamical Properties Within an Enzyme Superfamily. Frontiers in Molecular Biosciences. 5: 54. PMID 29946547 DOI: 10.3389/Fmolb.2018.00054  0.812
2018 Narayanan C, Bernard DN, Bafna K, Gagné D, Chennubhotla CS, Doucet N, Agarwal PK. Conservation of Dynamics Associated with Biological Function in an Enzyme Superfamily. Structure (London, England : 1993). PMID 29478822 DOI: 10.1016/J.Str.2018.01.015  0.823
2017 Narayanan C, Gagné D, Reynolds KA, Doucet N. Conserved amino acid networks modulate discrete functional properties in an enzyme superfamily. Scientific Reports. 7: 3207. PMID 28600532 DOI: 10.1038/S41598-017-03298-4  0.796
2017 Narayanan C, Bafna K, Roux LD, Agarwal PK, Doucet N. Applications of NMR and computational methodologies to study protein dynamics. Archives of Biochemistry and Biophysics. PMID 28483383 DOI: 10.1016/J.Abb.2017.05.002  0.779
2017 Gagné D, Narayanan C, Bafna K, Charest LA, Agarwal PK, Doucet N. Sequence-specific backbone resonance assignments and microsecond timescale molecular dynamics simulation of human eosinophil-derived neurotoxin. Biomolecular Nmr Assignments. PMID 28271277 DOI: 10.1007/S12104-017-9736-9  0.807
2017 Gagnon J, Sarvan S, Gagne D, Couture J, Doucet N. Human ribonuclease 6 crystal structure and conformational analysis Acta Crystallographica Section A. 73. DOI: 10.1107/S2053273317091732  0.706
2016 Narayanan C, Bernard DN, Doucet N. Role of Conformational Motions in Enzyme Function: Selected Methodologies and Case Studies. Catalysts (Basel, Switzerland). 6. PMID 28367322 DOI: 10.3390/Catal6060081  0.793
2016 Agarwal PK, Doucet N, Chennubhotla C, Ramanathan A, Narayanan C. Conformational Sub-states and Populations in Enzyme Catalysis. Methods in Enzymology. 578: 273-97. PMID 27497171 DOI: 10.1016/Bs.Mie.2016.05.023  0.463
2016 Gagné D, Narayanan C, Nguyen Thi N, Roux LD, Bernard DN, Brunzelle JS, Couture JF, Agarwal PK, Doucet N. Ligand Binding Enhances Millisecond Conformational Exchange in Xylanase B2 from Streptomyces lividans. Biochemistry. PMID 27387012 DOI: 10.1021/Acs.Biochem.6B00130  0.824
2016 Nguyen-Thi N, Doucet N. Combining chitinase C and N-acetylhexosaminidase from Streptomyces coelicolor A3(2) provides an efficient way to synthesize N-acetylglucosamine from crystalline chitin. Journal of Biotechnology. PMID 26767320 DOI: 10.1016/J.Jbiotec.2015.12.038  0.343
2016 Herrero C, Nguyen-Thi N, Hammerer F, Banse F, Gagné D, Doucet N, Mahy J, Ricoux R. Photoassisted Oxidation of Sulfides Catalyzed by Artificial Metalloenzymes Using Water as an Oxygen Source Catalysts. 6: 202. DOI: 10.3390/Catal6120202  0.667
2016 Gagnon J, Sarvan S, Gagné D, Couture J, Simonović M, Doucet N. Crystal structure and biophysical characterization of ligand-free and -bound RNases 4 and 6, members of the human RNase A superfamily Acta Crystallographica Section a Foundations and Advances. 72: s215-s215. DOI: 10.1107/S2053273316096753  0.717
2015 Gagné D, French RL, Narayanan C, Simonović M, Agarwal PK, Doucet N. Perturbation of the Conformational Dynamics of an Active-Site Loop Alters Enzyme Activity. Structure (London, England : 1993). 23: 2256-2266. PMID 26655472 DOI: 10.1016/J.Str.2015.10.011  0.828
2015 Vladoiu MC, Labrie M, Létourneau M, Egesborg P, Gagné D, Billard É, Grosset AA, Doucet N, Chatenet D, St-Pierre Y. Design of a peptidic inhibitor that targets the dimer interface of a prototypic galectin. Oncotarget. PMID 26543238 DOI: 10.18632/Oncotarget.5403  0.701
2015 Gobeil SM, Gagné D, Doucet N, Pelletier JN. (15)N, (13)C and (1)H backbone resonance assignments of an artificially engineered TEM-1/PSE-4 class A β-lactamase chimera and its deconvoluted mutant. Biomolecular Nmr Assignments. PMID 26386961 DOI: 10.1007/S12104-015-9645-8  0.781
2015 Gagné D, Narayanan C, Doucet N. Network of long-range concerted chemical shift displacements upon ligand binding to human angiogenin. Protein Science : a Publication of the Protein Society. 24: 525-33. PMID 25450558 DOI: 10.1002/Pro.2613  0.82
2015 Gagné D, Doucet N. Sequence-specific backbone (1)H, (13)C, and (15)N resonance assignments of human ribonuclease 4. Biomolecular Nmr Assignments. 9: 181-5. PMID 25030111 DOI: 10.1007/S12104-014-9570-2  0.752
2015 Gobeil SMC, Gagne D, Doucet N, Pelletier JN. 15N, 13C and 1H backbone resonance assignments of TEM-1(M68L-M69T) Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr26586  0.746
2015 St-Pierre Y, Grosset A, Labrie M, Gagné D, Vladoiu M, Gaboury L, Doucet N. Abstract P1-07-16: Galectin-7 increases resistance of breast cancer cells to drug-induced apoptosis and promotes tumor escape by killing T cells Cancer Research. 75. DOI: 10.1158/1538-7445.Sabcs14-P1-07-16  0.671
2014 Grosset AA, Labrie M, Gagné D, Vladoiu MC, Gaboury L, Doucet N, St-Pierre Y. Cytosolic galectin-7 impairs p53 functions and induces chemoresistance in breast cancer cells. Bmc Cancer. 14: 801. PMID 25367122 DOI: 10.1186/1471-2407-14-801  0.668
2014 Gobeil SM, Clouthier CM, Park J, Gagné D, Berghuis AM, Doucet N, Pelletier JN. Maintenance of native-like protein dynamics may not be required for engineering functional proteins. Chemistry & Biology. 21: 1330-40. PMID 25200606 DOI: 10.1016/J.Chembiol.2014.07.016  0.801
2014 Thi NN, Offen WA, Shareck F, Davies GJ, Doucet N. Structure and activity of the streptomyces coelicolor A3(2) β-N-acetylhexosaminidase provides further insight into GH20 family catalysis and inhibition Biochemistry. 53: 1789-1800. PMID 24559145 DOI: 10.1021/Bi401697J  0.411
2014 Grosset A, Gagné D, Labrie M, Vladoiu M, Gaboury L, Doucet N, St-Pierre Y. Abstract 1352: Cytoplasmic galectin-7 has an antiapoptotic function by decreasing p53 nuclear translocation in breast cancer cells Cancer Research. 74: 1352-1352. DOI: 10.1158/1538-7445.Am2014-1352  0.677
2014 Gagné D, Couture J, Simonović M, Doucet N. Structural and biophysical characterization of human RNase 6 Acta Crystallographica Section a Foundations and Advances. 70: C1643-C1643. DOI: 10.1107/S2053273314083569  0.755
2014 Thi Nguyen N, Doucet N. Structure of the S.coelicolor A3(2) N-acetylhexosaminidase provides insight into GH20 catalysis Acta Crystallographica Section a Foundations and Advances. 70: C1677-C1677. DOI: 10.1107/S2053273314083223  0.42
2013 Chatenet D, Folch B, Feytens D, Létourneau M, Tourwé D, Doucet N, Fournier A. Development and pharmacological characterization of conformationally constrained urotensin II-related peptide agonists. Journal of Medicinal Chemistry. 56: 9612-22. PMID 24251366 DOI: 10.1021/Jm401153J  0.312
2013 Folch B, Déziel E, Doucet N. Systematic Mutational Analysis of the Putative Hydrolase PqsE: Toward a Deeper Molecular Understanding of Virulence Acquisition in Pseudomonas aeruginosa Plos One. 8. PMID 24040042 DOI: 10.1371/Journal.Pone.0073727  0.485
2013 Gagné D, Doucet N. Structural and functional importance of local and global conformational fluctuations in the RNase A superfamily. The Febs Journal. 280: 5596-607. PMID 23763751 DOI: 10.1111/Febs.12371  0.526
2012 Clouthier CM, Morin S, Gobeil SM, Doucet N, Blanchet J, Nguyen E, Gagné SM, Pelletier JN. Chimeric β-lactamases: global conservation of parental function and fast time-scale dynamics with increased slow motions. Plos One. 7: e52283. PMID 23284969 DOI: 10.1371/Journal.Pone.0052283  0.791
2012 Gagné D, Charest LA, Morin S, Kovrigin EL, Doucet N. Conservation of flexible residue clusters among structural and functional enzyme homologues. The Journal of Biological Chemistry. 287: 44289-300. PMID 23135272 DOI: 10.1074/Jbc.M112.394866  0.78
2012 Brault G, Shareck F, Hurtubise Y, Lépine F, Doucet N. Isolation and characterization of EstC, a new cold-active esterase from Streptomyces coelicolor A3(2) Plos One. 7. PMID 22396747 DOI: 10.1371/Journal.Pone.0032041  0.357
2011 Doucet N, Khirich G, Kovrigin EL, Loria JP. Alteration of hydrogen bonding in the vicinity of histidine 48 disrupts millisecond motions in RNase A. Biochemistry. 50: 1723-30. PMID 21250662 DOI: 10.1021/Bi1018539  0.783
2011 Doucet N. Can enzyme engineering benefit from the modulation of protein motions? Lessons learned from NMR relaxation dispersion experiments Protein and Peptide Letters. 18: 336-343. PMID 21222641 DOI: 10.2174/092986611794653950  0.5
2011 Doucet N, Loria JP. Relaxation dispersion studies of enzyme motions Advances in Biomedical Spectroscopy. 3: 185-202. DOI: 10.3233/978-1-60750-695-9-185  0.628
2011 Doucet N, Pelletier JN. Gaining Insight into Enzyme Function through Correlation with Protein Motions Protein Engineering Handbook, Volume 1 & Volume 2. 1: 187-211. DOI: 10.1002/9783527634026.ch7  0.639
2010 Doucet N, Jayasundera TB, Simonovi? M, Loria JP. The crystal structure of ribonuclease A in complex with thymidine-3'-monophosphate provides further insight into ligand binding. Proteins. 78: 2459-68. PMID 20602460 DOI: 10.1002/Prot.22754  0.776
2009 Doucet N, Watt ED, Loria JP. The flexibility of a distant loop modulates active site motion and product release in ribonuclease A. Biochemistry. 48: 7160-8. PMID 19588901 DOI: 10.1021/Bi900830G  0.814
2009 De Wals PY, Doucet N, Pelletier JN. High tolerance to simultaneous active-site mutations in TEM-1 β-lactamase: Distinct mutational paths provide more generalized β-lactam recognition Protein Science. 18: 147-160. PMID 19177359 DOI: 10.1002/Pro.25  0.627
2007 Doucet N, Pelletier JN. Simulated annealing exploration of an active-site tyrosine in TEM-1β-lactamase suggests the existence of alternate conformations Proteins: Structure, Function and Genetics. 69: 340-348. PMID 17600829 DOI: 10.1002/Prot.21485  0.709
2007 Doucet N, Savard PY, Pelletier JN, Gagné SM. NMR investigation of Tyr105 mutants in TEM-1 beta-lactamase: dynamics are correlated with function. The Journal of Biological Chemistry. 282: 21448-59. PMID 17426035 DOI: 10.1074/Jbc.M609777200  0.697
2005 Chica RA, Doucet N, Pelletier JN. Semi-rational approaches to engineering enzyme activity: Combining the benefits of directed evolution and rational design Current Opinion in Biotechnology. 16: 378-384. PMID 15994074 DOI: 10.1016/J.Copbio.2005.06.004  0.785
2004 Doucet N, De Wals PY, Pelletier JN. Site-saturation mutagenesis of Tyr-105 reveals its importance in substrate stabilization and discrimination in TEM-1 β-lactamase Journal of Biological Chemistry. 279: 46295-46303. PMID 15326193 DOI: 10.1074/Jbc.M407606200  0.661
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