Hannah L. Klein, Ph.D. - Publications

Affiliations: 
Biochemistry New York University, New York, NY, United States 
Area:
Recombination

85 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Sui Y, Epstein A, Dominska M, Zheng DQ, Petes TD, Klein HL. Ribodysgenesis: sudden genome instability in the yeast Saccharomyces cerevisiae arising from RNase H2 cleavage at genomic-embedded ribonucleotides. Nucleic Acids Research. PMID 35748861 DOI: 10.1093/nar/gkac536  0.611
2021 Epshtein A, Symington LS, Klein HL. Intrachromosomal Recombination in Yeast. Methods in Molecular Biology (Clifton, N.J.). 2153: 193-200. PMID 32840781 DOI: 10.1007/978-1-0716-0644-5_14  0.66
2019 Klein HL, Symington LS. Recognition for Discoveries in DNA Repair. The New England Journal of Medicine. 381: 677-679. PMID 31412183 DOI: 10.1056/NEJMcibr1907358  0.619
2019 Potenski CJ, Epshtein A, Bianco C, Klein HL. Genome instability consequences of RNase H2 Aicardi-Goutières syndrome alleles. Dna Repair. PMID 30975634 DOI: 10.1016/J.Dnarep.2019.04.002  0.454
2019 Klein HL, Ang KKH, Arkin MR, Beckwitt EC, Chang YH, Fan J, Kwon Y, Morten MJ, Mukherjee S, Pambos OJ, El Sayyed H, Thrall ES, Vieira-da-Rocha JP, Wang Q, Wang S, et al. Guidelines for DNA recombination and repair studies: Mechanistic assays of DNA repair processes. Microbial Cell (Graz, Austria). 6: 65-101. PMID 30652106 DOI: 10.15698/Mic2019.01.665  0.457
2019 Klein HL, Bačinskaja G, Che J, Cheblal A, Elango R, Epshtein A, Fitzgerald DM, Gómez-González B, Khan SR, Kumar S, Leland BA, Marie L, Mei Q, Miné-Hattab J, Piotrowska A, et al. Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways. Microbial Cell (Graz, Austria). 6: 1-64. PMID 30652105 DOI: 10.15698/Mic2019.01.664  0.717
2018 Mansisidor A, Molinar T, Srivastava P, Dartis DD, Pino Delgado A, Blitzblau HG, Klein H, Hochwagen A. Genomic Copy-Number Loss Is Rescued by Self-Limiting Production of DNA Circles. Molecular Cell. PMID 30293780 DOI: 10.1016/J.Molcel.2018.08.036  0.451
2017 Klein HL. Genome instabilities arising from ribonucleotides in DNA. Dna Repair. PMID 28629774 DOI: 10.1016/J.Dnarep.2017.06.004  0.519
2016 Epshtein A, Potenski CJ, Klein HL. Increased Spontaneous Recombination in RNase H2-Deficient Cells Arises From Multiple Contiguous rNMPs and Not From Single rNMP Residues Incorporated by DNA Polymerase Epsilon. Microbial Cell (Graz, Austria). 3: 248-254. PMID 28203566 DOI: 10.15698/mic2016.06.506  0.384
2016 Niu H, Klein HL. Multifunctional Roles of Saccharomyces cerevisiae Srs2 protein in Replication, Recombination and Repair. Fems Yeast Research. PMID 28011904 DOI: 10.1093/Femsyr/Fow111  0.501
2015 Niu H, Potenski CJ, Epshtein A, Sung P, Klein HL. Roles of DNA helicases and Exo1 in the avoidance of mutations induced by Top1-mediated cleavage at ribonucleotides in DNA. Cell Cycle (Georgetown, Tex.). 0. PMID 26716562 DOI: 10.1080/15384101.2015.1128594  0.385
2015 Jinks-Robertson S, Klein HL. Ribonucleotides in DNA: Hidden in plain sight Nature Structural and Molecular Biology. 22: 176-178. PMID 25736085 DOI: 10.1038/Nsmb.2981  0.679
2014 Potenski CJ, Klein HL. How the misincorporation of ribonucleotides into genomic DNA can be both harmful and helpful to cells. Nucleic Acids Research. 42: 10226-34. PMID 25159610 DOI: 10.1093/Nar/Gku773  0.396
2014 Potenski CJ, Niu H, Sung P, Klein HL. Avoidance of ribonucleotide-induced mutations by RNase H2 and Srs2-Exo1 mechanisms. Nature. 511: 251-4. PMID 24896181 DOI: 10.1038/Nature13292  0.398
2014 Potenski CJ, Klein HL. How the misincorporation of ribonucleotides into genomic DNA can be both harmful and helpful to cells Nucleic Acids Research. 42: 10226-10234. DOI: 10.1093/nar/gku773  0.35
2013 Burgess RC, Sebesta M, Sisakova A, Marini VP, Lisby M, Damborsky J, Klein H, Rothstein R, Krejci L. The PCNA interaction protein box sequence in Rad54 is an integral part of its ATPase domain and is required for efficient DNA repair and recombination. Plos One. 8: e82630. PMID 24376557 DOI: 10.1371/Journal.Pone.0082630  0.46
2013 Maria SRS, Kwon YH, Sung P, Klein HL. Characterization of the interaction between the saccharomyces cerevisiae Rad51 recombinase and the DNA translocase Rdh54 Journal of Biological Chemistry. 288: 21999-22005. PMID 23798704 DOI: 10.1074/Jbc.M113.480475  0.432
2013 Potenski CJ, Klein HL. Death becomes her: FBH1, DNA damage and apoptosis Cell Cycle. 12: 1336-1337. PMID 23588074 DOI: 10.4161/Cc.24668  0.463
2013 Ferrari M, Nachimuthu BT, Donnianni RA, Klein H, Pellicioli A. Tid1/Rdh54 translocase is phosphorylated through a Mec1- and Rad53-dependent manner in the presence of DSB lesions in budding yeast. Dna Repair. 12: 347-55. PMID 23473644 DOI: 10.1016/J.Dnarep.2013.02.004  0.442
2012 Klein HL, Symington LS. Sgs1--the maestro of recombination. Cell. 149: 257-9. PMID 22500794 DOI: 10.1016/J.Cell.2012.03.020  0.612
2011 Potenski CJ, Klein HL. R we there yet? R-loop hazards to finishing the journey. Molecular Cell. 44: 848-50. PMID 22195960 DOI: 10.1016/J.Molcel.2011.12.003  0.404
2011 Hoot SJ, Zheng X, Potenski CJ, White TC, Klein HL. The role of Candida albicans homologous recombination factors Rad54 and Rdh54 in DNA damage sensitivity. Bmc Microbiology. 11: 214. PMID 21951709 DOI: 10.1186/1471-2180-11-214  0.394
2011 Bermejo R, Capra T, Jossen R, Colosio A, Frattini C, Carotenuto W, Cocito A, Doksani Y, Klein H, Gómez-González B, Aguilera A, Katou Y, Shirahige K, Foiani M. The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores Cell. 146: 233-246. PMID 21784245 DOI: 10.1016/J.Cell.2011.06.033  0.408
2011 Zheng X, Epstein A, Klein HL. Methods to study mitotic homologous recombination and genome stability. Methods in Molecular Biology (Clifton, N.J.). 745: 3-13. PMID 21660685 DOI: 10.1007/978-1-61779-129-1_1  0.462
2011 Chi P, Kwon YH, Visnapuu ML, Lam I, Santa Maria SR, Zheng X, Epshtein A, Greene EC, Sung P, Klein HL. Analyses of the yeast Rad51 recombinase A265V mutant reveal different in vivo roles of Swi2-like factors Nucleic Acids Research. 39: 6511-6522. PMID 21558173 DOI: 10.1093/Nar/Gkr297  0.509
2011 Potenski CJ, Klein HL. Molecular biology: The expanding arena of DNA repair Nature. 471: 48-49. PMID 21368822 DOI: 10.1038/471048A  0.46
2011 Hoot SJ, Zheng X, Potenski CJ, White TC, Klein HL. The role of Candida albicans homologous recombination factors Rad54 and Rdh54 in DNA damage sensitivity Bmc Microbiology. 11. DOI: 10.1186/1471-2180-11-214  0.334
2010 Shah PP, Zheng X, Epshtein A, Carey JN, Bishop DK, Klein HL. Swi2/Snf2-related translocases prevent accumulation of toxic Rad51 complexes during mitotic growth Molecular Cell. 39: 862-872. PMID 20864034 DOI: 10.1016/j.molcel.2010.08.028  0.353
2010 Saponaro M, Callahan D, Zheng X, Krejci L, Haber JE, Klein HL, Liberi G. Cdk1 targets Srs2 to complete synthesis-dependent strand annealing and to promote recombinational repair Plos Genetics. 6. PMID 20195513 DOI: 10.1371/Journal.Pgen.1000858  0.455
2009 Colavito S, Macris-Kiss M, Seong C, Gleeson O, Greene EC, Klein HL, Krejci L, Sung P. Functional significance of the Rad51-Srs2 complex in Rad51 presynaptic filament disruption Nucleic Acids Research. 37: 6754-6764. PMID 19745052 DOI: 10.1093/Nar/Gkp748  0.4
2009 Robertson RB, Moses DN, Kwon Y, Chan P, Chi P, Klein H, Sung P, Greene EC. Structural transitions within human Rad51 nucleoprotein filaments. Proceedings of the National Academy of Sciences of the United States of America. 106: 12688-93. PMID 19622740 DOI: 10.1073/Pnas.0811465106  0.398
2009 Klein HL, Symington LS. Breaking up just got easier to do. Cell. 138: 20-2. PMID 19596231 DOI: 10.1016/J.Cell.2009.06.039  0.552
2009 Robertson RB, Moses DN, Kwon Y, Chan P, Zhao W, Chi P, Klein H, Sung P, Greene EC. Visualizing the disassembly of S. cerevisiae Rad51 nucleoprotein filaments. Journal of Molecular Biology. 388: 703-20. PMID 19327367 DOI: 10.1016/J.Jmb.2009.03.049  0.429
2009 Prakash R, Satory D, Dray E, Papusha A, Scheller J, Kramer W, Krejci L, Klein H, Haber JE, Sung P, Ira G. Yeast Mphl helicase dissociates Rad51-made D-loops: Implications for crossover control in mitotic recombination Genes and Development. 23: 67-79. PMID 19136626 DOI: 10.1101/Gad.1737809  0.459
2009 Chi P, Kwon Y, Moses DN, Seong C, Sehorn MG, Singh AK, Tsubouchi H, Greene EC, Klein HL, Sung P. Functional interactions of meiotic recombination factors Rdh54 and Dmc1. Dna Repair. 8: 279-84. PMID 19028606 DOI: 10.1016/J.Dnarep.2008.10.012  0.366
2008 Klein HL. Molecular biology: DNA endgames Nature. 455: 740-741. PMID 18843352 DOI: 10.1038/455740A  0.446
2008 Kwon Y, Seong C, Chi P, Greene EC, Klein H, Sung P. ATP-dependent chromatin remodeling by the Saccharomyces cerevisiae homologous recombination factor Rdh54. The Journal of Biological Chemistry. 283: 10445-52. PMID 18292093 DOI: 10.1074/Jbc.M800082200  0.469
2008 San Filippo J, Sung P, Klein H. Mechanism of eukaryotic homologous recombination. Annual Review of Biochemistry. 77: 229-57. PMID 18275380 DOI: 10.1146/Annurev.Biochem.77.061306.125255  0.45
2008 Klein HL. The consequences of Rad51 overexpression for normal and tumor cells Dna Repair. 7: 686-693. PMID 18243065 DOI: 10.1016/J.Dnarep.2007.12.008  0.453
2007 Klein HL. Reversal of Fortune: Rad5 to the Rescue Molecular Cell. 28: 181-183. PMID 17964257 DOI: 10.1016/J.Molcel.2007.10.001  0.428
2007 Kwon Y, Chi P, Roh DH, Klein H, Sung P. Synergistic action of the Saccharomyces cerevisiae homologous recombination factors Rad54 and Rad51 in chromatin remodeling. Dna Repair. 6: 1496-506. PMID 17544928 DOI: 10.1016/J.Dnarep.2007.04.012  0.417
2007 Klein HL. DNA helicases in recombination Topics in Current Genetics. 17: 1-26. DOI: 10.1007/4735_2006_0201  0.338
2006 Klein HL. A SUMOry of DNA Replication: Synthesis, Damage, and Repair Cell. 127: 455-457. PMID 17081966 DOI: 10.1016/J.Cell.2006.10.019  0.426
2006 Sung P, Klein H. Mechanism of homologous recombination: mediators and helicases take on regulatory functions. Nature Reviews. Molecular Cell Biology. 7: 739-50. PMID 16926856 DOI: 10.1038/Nrm2008  0.431
2006 Chi P, Kwon Y, Seong C, Epshtein A, Lam I, Sung P, Klein HL. Yeast recombination factor Rdh54 functionally interacts with the Rad51 recombinase and catalyzes Rad51 removal from DNA Journal of Biological Chemistry. 281: 26268-26279. PMID 16831867 DOI: 10.1074/Jbc.M602983200  0.495
2006 Klein HL. Recombination and Genome Rearrangements Reviews in Cell Biology and Molecular Medicine. DOI: 10.1002/3527600906.Mcb.200400163  0.501
2005 Monroe DS, Leitzel AK, Klein HL, Matson SW. Biochemical and genetic characterization of Hmi1p, a yeast DNA helicase involved in the maintenance of mitochondrial DNA Yeast. 22: 1269-1286. PMID 16358299 DOI: 10.1002/Yea.1313  0.462
2004 Xu H, Boone C, Klein HL. Mrc1 is required for sister chromatid cohesion to aid in recombination repair of spontaneous damage Molecular and Cellular Biology. 24: 7082-7090. PMID 15282308 DOI: 10.1128/Mcb.24.16.7082-7090.2004  0.517
2004 Smirnova M, Van Komen S, Sung P, Klein HL. Effects of tumor-associated mutations on Rad54 functions Journal of Biological Chemistry. 279: 24081-24088. PMID 15056673 DOI: 10.1074/Jbc.M402719200  0.499
2004 Krejci L, Macris M, Li Y, Van Komen S, Villemain J, Ellenberger T, Klein H, Sung P. Role of ATP hydrolysis in the antirecombinase function of Saccharomyces cerevisiae Srs2 protein. The Journal of Biological Chemistry. 279: 23193-9. PMID 15047689 DOI: 10.1074/Jbc.M402586200  0.503
2003 Smirnova M, Klein HL. Role of the error-free damage bypass postreplication repair pathway in the maintenance of genomic stability Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 532: 117-135. PMID 14643433 DOI: 10.1016/J.Mrfmmm.2003.08.026  0.438
2003 Van Komen S, Reddy MS, Krejci L, Klein H, Sung P. ATPase and DNA helicase activities of the Saccharomyces cerevisiae anti-recombinase Srs2. The Journal of Biological Chemistry. 278: 44331-7. PMID 12966095 DOI: 10.1074/Jbc.M307256200  0.477
2003 Krejci L, Van Komen S, Li Y, Villemain J, Reddy MS, Klein H, Ellenberger T, Sung P. DNA helicase Srs2 disrupts the Rad51 presynaptic filament Nature. 423: 305-309. PMID 12748644 DOI: 10.1038/Nature01577  0.494
2002 Merker RJ, Klein HL. Role of transcription in plasmid maintenance in the hpr1Δ mutant of Saccharomyces cerevisiae Molecular and Cellular Biology. 22: 8763-8773. PMID 12446793 DOI: 10.1128/Mcb.22.24.8763-8773.2002  0.737
2002 Klein HL, Kreuzer KN. Replication, recombination, and repair: Going for the gold Molecular Cell. 9: 471-480. PMID 11931756 DOI: 10.1016/S1097-2765(02)00493-8  0.455
2002 Merker RJ, Klein HL. hpr1Δ affects ribosomal DNA recombination and cell life span in Saccharomyces cerevisiae Molecular and Cellular Biology. 22: 421-429. PMID 11756539 DOI: 10.1128/Mcb.22.2.421-429.2002  0.755
2001 Klein HL. Spontaneous chromosome loss in Saccharomyces cerevisiae is suppressed by DNA damage checkpoint functions Genetics. 159: 1501-1509. PMID 11779792  0.371
2001 Fan HY, Merker RJ, Klein HL. High-copy-number expression of Sub2p, a member of the RNA helicase superfamily, suppresses hpr1-mediated genomic instability Molecular and Cellular Biology. 21: 5459-5470. PMID 11463828 DOI: 10.1128/Mcb.21.16.5459-5470.2001  0.733
2001 Signon L, Malkova A, Naylor ML, Klein H, Haber JE. Genetic requirements for RAD51- and RAD54-independent break-induced replication repair of a chromosomal double-strand break. Molecular and Cellular Biology. 21: 2048-56. PMID 11238940 DOI: 10.1128/Mcb.21.6.2048-2056.2001  0.462
2001 Klein HL. Mutations in recombinational repair and in checkpoint control genes suppress the lethal combination of srs2Δ with other DNA repair genes in Saccharomyces cerevisiae Genetics. 157: 557-565. PMID 11156978  0.401
2000 Petukhova G, Sung P, Klein H. Promotion of Rad51-dependent D-loop formation by yeast recombination factor Rdh54/Tid1. Genes & Development. 14: 2206-15. PMID 10970884 DOI: 10.1101/Gad.826100  0.423
2000 Hegde V, Klein H. Requirement for the SRS2 DNA helicase gene in non-homologous end joining in yeast Nucleic Acids Research. 28: 2779-2783. PMID 10908335 DOI: 10.1093/Nar/28.14.2779  0.507
2000 Klein HL. A radical solution to death Nature Genetics. 25: 132-134. PMID 10835619 DOI: 10.1038/75957  0.406
2000 Schneiter R, Guerra CE, Lampl M, Tatzer V, Zellnig G, Klein HL, Kohlwein SD. A novel cold-sensitive allele of the rate-limiting enzyme of fatty acid synthesis, acetyl coenzyme A carboxylase, affects the morphology of the yeast vacuole through acylation of Vac8p Molecular and Cellular Biology. 20: 2984-2995. PMID 10757783 DOI: 10.1128/Mcb.20.9.2984-2995.2000  0.326
1999 Schneiter R, Guerra CE, Lampl M, Gogg G, Kohlwein SD, Klein HL. The Saccharomyces cerevisiae hyperrecombination mutant hpr1Δ is synthetically lethal with two conditional alleles of the acetyl coenzyme a carboxylase gene and causes a defect in nuclear export of polyadenylated RNA Molecular and Cellular Biology. 19: 3415-3422. PMID 10207065 DOI: 10.1128/Mcb.19.5.3415  0.409
1999 Chang M, French-Cornay D, Fan HY, Klein H, Denis CL, Jaehning JA. A complex containing RNA polymerase II, Paf1p, Cdc73p, Hpr1p, and Ccr4p plays a role in protein kinase C signaling Molecular and Cellular Biology. 19: 1056-1067. PMID 9891041 DOI: 10.1128/Mcb.19.2.1056  0.587
1998 Vainberg IE, Lewis SA, Rommelaere H, Ampe C, Vandekerckhove J, Klein HL, Cowan NJ. Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. Cell. 93: 863-73. PMID 9630229 DOI: 10.1016/S0092-8674(00)81446-4  0.315
1997 Klein HL. RDH54, a RAD54 homologue in Saccharomyces cerevisiae, is required for mitotic diploid-specific recombination and repair and for meiosis Genetics. 147: 1533-1543. PMID 9409819  0.332
1996 Fan HY, Cheng KK, Klein HL. Mutations in the RNA Polymerase II transcription machinery suppress the hyperrecombination Mutant hpr1Δ of Saccharomyces cerevisiae Genetics. 142: 749-759. PMID 8849885  0.575
1995 Klein HL. Genetic control of intrachromosomal recombination Bioessays. 17: 147-159. PMID 7748165 DOI: 10.1002/Bies.950170210  0.394
1995 Klein HL. Examination of mitotic recombination by means of hyper-recombination mutants in Saccharomyces cerevisiae Progress in Nucleic Acid Research and Molecular Biology. 51: 271-303. PMID 7659776 DOI: 10.1016/S0079-6603(08)60881-8  0.527
1995 Guerra CE, Klein HL. Mapping of the ACC1/FAS3 gene to the right arm of chromosome XIV of Saccharomyces cerevisiae Yeast. 11: 697-700. PMID 7483843 DOI: 10.1002/Yea.320110711  0.323
1994 Fan HY, Klein HL. Characterization of mutations that suppress the temperature-sensitive growth of the hpr1Δ mutant of Saccharomyces cerevisiae Genetics. 137: 945-956. PMID 7982575  0.511
1992 Palladino F, Klein HL. Analysis of mitotic and meiotic defects in Saccharomyces cerevisiae SRS2 DNA helicase mutants Genetics. 132: 23-37. PMID 1327956  0.343
1990 Lucchini G, Falconi MM, Pizzagalli A, Aguilera A, Klein HL, Plevani P. Nucleotide sequence and characterization of temperature-sensitive pol1 mutants of Saccharomyces cerevisiae Gene. 90: 99-104. PMID 2199334 DOI: 10.1016/0378-1119(90)90444-V  0.49
1990 Aguilera A, Klein HL. HPR1, a novel yeast gene that prevents intrachromosomal excision recombination, shows carboxy-terminal homology to the Saccharomyces cerevisiae TOP1 gene Molecular and Cellular Biology. 10: 1439-1451. PMID 2181275 DOI: 10.1128/Mcb.10.4.1439  0.375
1990 Aguilera A, Moskowitz P, Klein HL. Molecular analysis of RGP1, a new yeast gene required for proper mitotic growth Nucleic Acids Research. 18: 1064. PMID 2179863 DOI: 10.1093/Nar/18.4.1064  0.306
1989 Button LL, Russell DG, Klein HL, Medina-Acosta E, Karess RE, McMaster WR. Genes encoding the major surface glycoprotein in Leishmania are tandemly linked at a single chromosomal locus and are constitutively transcribed. Molecular and Biochemical Parasitology. 32: 271-83. PMID 2927448 DOI: 10.1016/0166-6851(89)90076-5  0.346
1989 Aguilera A, Klein HL. Genetic and molecular analysis of recombination events in Saccharomyces cerevisiae occurring in the presence of the hyper-recombination mutation hpr1. Genetics. 122: 503-517. PMID 2668113  0.303
1988 Aguilera A, Klein HL. Genetic control of intrachromosomal recombination in Saccharomyces cerevisiae. I. Isolation and genetic characterization of hyper-recombination mutations. Genetics. 119: 779-790. PMID 3044923  0.317
1984 Klein HL, Petes TD. Genetic mapping of Ty elements in Saccharomyces cerevisiae Molecular and Cellular Biology. 4: 329-339. PMID 6366520 DOI: 10.1128/Mcb.4.2.329  0.54
1984 Klein HL. Lack of association between intrachromosomal gene conversion and reciprocal exchange Nature. 310: 748-753. PMID 6088989 DOI: 10.1038/310748A0  0.312
1981 Klein HL, Petes TD. Intrachromosomal gene conversion in yeast Nature. 289: 144-148. PMID 7005693 DOI: 10.1038/289144A0  0.517
1980 Klein HL, Welch SK. Inverted repeated sequences in yeast nuclear DNA. Nucleic Acids Research. 8: 4651-69. PMID 7003542 DOI: 10.1093/Nar/8.20.4651  0.414
1978 Klein HL, Byers B. Stable denaturation of chromosomal DNA from Saccharomyces cerevisiae during meiosis. Journal of Bacteriology. 134: 629-35. PMID 350830  0.315
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