Roderic G. Eckenhoff - Publications

Anesthesiology and Critical Care University of Pennsylvania Perelman School of Medicine 
Anesthetic pharmacology

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Year Citation  Score
2021 Joseph TT, Bu W, Lin W, Zoubak L, Yeliseev A, Liu R, Eckenhoff RG, Brannigan G. Ketamine Metabolite (2,6)-Hydroxynorketamine Interacts with μ and κ Opioid Receptors. Acs Chemical Neuroscience. PMID 33905229 DOI: 10.1021/acschemneuro.0c00741  0.48
2020 White ER, Leace DM, Bedell VM, Bhanu NV, Garcia BA, Dailey WP, Eckenhoff RG. Synthesis and Characterization of a Diazirine-Based Photolabel of the Nonanesthetic Fropofol. Acs Chemical Neuroscience. PMID 33355437 DOI: 10.1021/acschemneuro.0c00667  0.48
2020 Wague A, Joseph TT, Woll KA, Bu W, Vaidya KA, Bhanu NV, Garcia BA, Nimigean CM, Eckenhoff RG, Riegelhaupt PM. Mechanistic insights into volatile anesthetic modulation of K2P channels. Elife. 9. PMID 33345771 DOI: 10.7554/eLife.59839  0.48
2020 Koutsogiannaki S, Bu W, Hou L, Shibamura-Fujiogi M, Ishida H, Ohto U, Eckenhoff RG, Yuki K. The effect of anesthetics on toll like receptor 9. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 34: 14645-14654. PMID 32901993 DOI: 10.1096/Fj.202000791Rr  0.4
2020 Yuki K, Bu W, Eckenhoff RG, Yokomizo T, Okuno T. The role of propofol hydroxyl group in 5-lipoxygenase recognition. Biochemical and Biophysical Research Communications. PMID 32171526 DOI: 10.1016/J.Bbrc.2020.03.037  0.4
2019 Okuno T, Koutsogiannaki S, Hou L, Bu W, Ohto U, Eckenhoff RG, Yokomizo T, Yuki K. Volatile anesthetics isoflurane and sevoflurane directly target and attenuate Toll-like receptor 4 system. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201901570R. PMID 31675483 DOI: 10.1096/Fj.201901570R  0.4
2019 McKinstry-Wu A, Woll KA, Joseph T, Bu W, White ER, Bhanu NV, Garcia BA, Brannigan G, Dailey WP, Eckenhoff RG. Azi-medetomidine: Synthesis and Characterization of a Novel α2 Adrenergic Photoaffinity Ligand. Acs Chemical Neuroscience. PMID 31638765 DOI: 10.1021/Acschemneuro.9B00484  0.48
2019 Huang Y, Lu H, Ren X, Li F, Bu W, Liu W, Daily WP, Saeki H, Gabrielson K, Abraham R, Eckenhoff R, Dong Gao W. Fropofol Prevents Disease Progression in Mice with Hypertrophic Cardiomyopathy. Cardiovascular Research. PMID 31424496 DOI: 10.1093/Cvr/Cvz218  0.4
2019 Zha H, Matsunami E, Blazon-Brown N, Koutsogiannaki S, Hou L, Bu W, Babazada H, Odegard KC, Liu R, Eckenhoff RG, Yuki K. Volatile anesthetics affect macrophage phagocytosis. Plos One. 14: e0216163. PMID 31071106 DOI: 10.1371/Journal.Pone.0216163  0.4
2018 Wang Y, Yang E, Wells MM, Bondarenko V, Woll K, Carnevale V, Granata D, Klein ML, Eckenhoff RG, Dailey WP, Covarrubias M, Tang P, Xu Y. Propofol inhibits the voltage-gated sodium channel NaChBac at multiple sites. The Journal of General Physiology. PMID 30018039 DOI: 10.1085/Jgp.201811993  0.48
2018 Woll KA, Guzik-Lendrum S, Bensel BM, Bhanu NV, Dailey WP, Garcia BA, Gilbert SP, Eckenhoff RG. An allosteric propofol-binding site in kinesin disrupts kinesin-mediated processive movement on microtubules. The Journal of Biological Chemistry. PMID 29844014 DOI: 10.1074/Jbc.Ra118.002182  0.48
2018 Woll KA, Dailey WP, Eckenhoff RG. Identification of General Anesthetic Target Protein-Binding Sites by Photoaffinity Labeling and Mass Spectrometry. Methods in Enzymology. 602: 231-246. PMID 29588031 DOI: 10.1016/Bs.Mie.2018.01.009  0.48
2018 Woll KA, Eckenhoff RG. High-Throughput Screening to Identify Anesthetic Ligands Using Xenopus laevis Tadpoles. Methods in Enzymology. 602: 177-187. PMID 29588028 DOI: 10.1016/Bs.Mie.2018.01.007  0.48
2018 Ren X, Schmidt W, Huang Y, Lu H, Liu W, Bu W, Eckenhoff R, Cammarato A, Gao WD. Fropofol decreases force development in cardiac muscle. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201701442R. PMID 29522375 DOI: 10.1096/Fj.201701442R  0.4
2018 Woll KA, Zhou X, Bhanu NV, Garcia BA, Covarrubias M, Miller KW, Eckenhoff RG. Identification of binding sites contributing to volatile anesthetic effects on GABA type A receptors. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201701347R. PMID 29505303 DOI: 10.1096/Fj.201701347R  0.48
2017 Woll KA, Skinner KA, Gianti E, Bhanu NV, Garcia BA, Carnevale V, Eckenhoff RG, Gaudet R. Sites Contributing to TRPA1 Activation by the Anesthetic Propofol Identified by Photoaffinity Labeling. Biophysical Journal. PMID 28935134 DOI: 10.1016/J.Bpj.2017.08.040  0.48
2017 Bensel BM, Guzik-Lendrum S, Masucci EM, Woll KA, Eckenhoff RG, Gilbert SP. Common general anesthetic propofol impairs kinesin processivity. Proceedings of the National Academy of Sciences of the United States of America. PMID 28484025 DOI: 10.1073/Pnas.1701482114  0.48
2017 Woll KA, Peng W, Liang Q, Zhi L, Jacobs JA, Maciunas L, Bhanu N, Garcia BA, Covarrubias M, Loll PJ, Dailey WP, Eckenhoff RG. Photoaffinity ligand for the inhalational anesthetic sevoflurane allows mechanistic insight into potassium channel modulation. Acs Chemical Biology. PMID 28333442 DOI: 10.1021/Acschembio.7B00222  0.48
2017 Bu W, Liang Q, Zhi L, Maciunas L, Loll PJ, Eckenhoff RG, Covarrubias M. Sites and Functional Consequence of Alkylphenol Anesthetic Binding to Kv1.2 Channels. Molecular Neurobiology. PMID 28204960 DOI: 10.1007/S12035-017-0437-2  0.4
2017 Okuno T, Koutsogiannaki S, Ohba M, Chamberlain M, Bu W, Lin FY, Eckenhoff RG, Yokomizo T, Yuki K. Intravenous anesthetic propofol binds to 5-lipoxygenase and attenuates leukotriene B4 production. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28069825 DOI: 10.1096/Fj.201601095R  0.4
2016 Kinde MN, Bondarenko V, Granata D, Bu W, Grasty KC, Loll PJ, Carnevale V, Klein ML, Eckenhoff RG, Tang P, Xu Y. Fluorine-19 NMR and computational quantification of isoflurane binding to the voltage-gated sodium channel NaChBac. Proceedings of the National Academy of Sciences of the United States of America. PMID 27856739 DOI: 10.1073/Pnas.1609939113  0.44
2016 Woll KA, Dailey WP, Brannigan G, Eckenhoff RG. Shedding Light on Anesthetic Mechanisms: Application of Photoaffinity Ligands. Anesthesia and Analgesia. PMID 27464974 DOI: 10.1213/Ane.0000000000001365  0.48
2016 Woll KA, Murlidaran S, Pinch BJ, Hénin J, Wang X, Salari R, Covarrubias M, Dailey WP, Brannigan G, Garcia BA, Eckenhoff RG. A Novel Bifunctional Alkylphenol Anesthetic Allows Characterization of GABAA Receptor Subunit Binding Selectivity in Synaptosomes. The Journal of Biological Chemistry. PMID 27462076 DOI: 10.1074/Jbc.M116.736975  0.48
2016 Eckenhoff RG, Hogan KJ, Evered L. Fallacy…. Really? Anesthesiology. 125: 426-8. PMID 27433760 DOI: 10.1097/ALN.0000000000001180  0.44
2016 Meng T, Bu W, Ren X, Chen X, Yu J, Eckenhoff RG, Gao WD. Molecular mechanism of anesthetic-induced depression of myocardial contraction. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 27170289 DOI: 10.1096/Fj.201600290Rr  0.44
2016 Kinde MN, Bu W, Chen Q, Xu Y, Eckenhoff RG, Tang P. Common Anesthetic-binding Site for Inhibition of Pentameric Ligand-gated Ion Channels. Anesthesiology. PMID 26756520 DOI: 10.1097/Aln.0000000000001005  0.4
2015 Ward CM, Hogan KJ, Eckenhoff RG. Potential Adverse Effects of Anesthesia in Children. Jama. 314: 408-9. PMID 26219064 DOI: 10.1001/Jama.2015.7378  0.44
2015 Linganna RE, Levy WJ, Dmochowski IJ, Eckenhoff RG, Speck RM. Taxane modulation of anesthetic sensitivity in surgery for nonmetastatic breast cancer. Journal of Clinical Anesthesia. PMID 26036970 DOI: 10.1016/J.Jclinane.2015.05.001  0.44
2015 Weiser BP, Hall MA, Weinbren NL, Woll KA, Dailey WP, Eckenhoff MF, Eckenhoff RG. Macroscopic and macromolecular specificity of alkylphenol anesthetics for neuronal substrates. Scientific Reports. 5: 9695. PMID 25853337 DOI: 10.1038/Srep09695  0.44
2015 Ho J, Perez-Aguilar JM, Gao L, Saven JG, Matsunami H, Eckenhoff RG. Molecular recognition of ketamine by a subset of olfactory G protein-coupled receptors. Science Signaling. 8: ra33. PMID 25829447 DOI: 10.1126/Scisignal.2005912  0.44
2015 Woll KA, Weiser BP, Liang Q, Meng T, McKinstry-Wu A, Pinch B, Dailey WP, Gao WD, Covarrubias M, Eckenhoff RG. Role for the Propofol Hydroxyl in Anesthetic Protein Target Molecular Recognition. Acs Chemical Neuroscience. 6: 927-35. PMID 25799399 DOI: 10.1021/Acschemneuro.5B00078  0.44
2015 Weiser BP, Eckenhoff RG. Propofol inhibits SIRT2 deacetylase through a conformation-specific, allosteric site. The Journal of Biological Chemistry. 290: 8559-68. PMID 25666612 DOI: 10.1074/Jbc.M114.620732  0.44
2015 McKinstry-Wu AR, Bu W, Rai G, Lea WA, Weiser BP, Liang DF, Simeonov A, Jadhav A, Maloney DJ, Eckenhoff RG. Discovery of a novel general anesthetic chemotype using high-throughput screening. Anesthesiology. 122: 325-33. PMID 25603205 DOI: 10.1097/Aln.0000000000000505  0.44
2014 Weiser BP, Bu W, Wong D, Eckenhoff RG. Sites and functional consequence of VDAC-alkylphenol anesthetic interactions. Febs Letters. 588: 4398-403. PMID 25448677 DOI: 10.1016/J.Febslet.2014.10.009  0.44
2014 Jayakar SS, Zhou X, Chiara DC, Dostalova Z, Savechenkov PY, Bruzik KS, Dailey WP, Miller KW, Eckenhoff RG, Cohen JB. Multiple propofol-binding sites in a γ-aminobutyric acid type A receptor (GABAAR) identified using a photoreactive propofol analog. The Journal of Biological Chemistry. 289: 27456-68. PMID 25086038 DOI: 10.1074/Jbc.M114.581728  0.44
2014 Weiser BP, Salari R, Eckenhoff RG, Brannigan G. Computational investigation of cholesterol binding sites on mitochondrial VDAC. The Journal of Physical Chemistry. B. 118: 9852-60. PMID 25080204 DOI: 10.1021/Jp504516A  0.48
2014 Bu W, Pereira LM, Eckenhoff RG, Yuki K. Stereoselectivity of isoflurane in adhesion molecule leukocyte function-associated antigen-1. Plos One. 9: e96649. PMID 24801074 DOI: 10.1371/Journal.Pone.0096649  0.44
2014 Barber AF, Carnevale V, Klein ML, Eckenhoff RG, Covarrubias M. Modulation of a voltage-gated Na+ channel by sevoflurane involves multiple sites and distinct mechanisms. Proceedings of the National Academy of Sciences of the United States of America. 111: 6726-31. PMID 24753583 DOI: 10.1073/Pnas.1405768111  0.44
2014 Weiser BP, Woll KA, Dailey WP, Eckenhoff RG. Mechanisms revealed through general anesthetic photolabeling. Current Anesthesiology Reports. 4: 57-66. PMID 24563623 DOI: 10.1007/S40140-013-0040-7  0.48
2014 Chiara DC, Gill JF, Chen Q, Tillman T, Dailey WP, Eckenhoff RG, Xu Y, Tang P, Cohen JB. Photoaffinity labeling the propofol binding site in GLIC. Biochemistry. 53: 135-42. PMID 24341978 DOI: 10.1021/Bi401492K  0.44
2014 Weiser BP, Salari R, Eckenhoff RG, Brannigan G. Computational investigation of cholesterol binding sites on mitochondrial VDAC Journal of Physical Chemistry B. 118: 9852-9860. DOI: 10.1021/jp504516a  0.44
2013 Yuki K, Bu W, Xi J, Shimaoka M, Eckenhoff R. Propofol shares the binding site with isoflurane and sevoflurane on leukocyte function-associated antigen-1. Anesthesia and Analgesia. 117: 803-11. PMID 23960033 DOI: 10.1213/Ane.0B013E3182A00Ae0  0.44
2013 Yuki K, Bu W, Shimaoka M, Eckenhoff R. Volatile Anesthetics, Not Intravenous Anesthetic Propofol Bind to and Attenuate the Activation of Platelet Receptor Integrin αIIbβ3 Plos One. 8. PMID 23573252 DOI: 10.1371/Journal.Pone.0060415  0.44
2013 Emerson DJ, Weiser BP, Psonis J, Liao Z, Taratula O, Fiamengo A, Wang X, Sugasawa K, Smith AB, Eckenhoff RG, Dmochowski IJ. Direct modulation of microtubule stability contributes to anthracene general anesthesia. Journal of the American Chemical Society. 135: 5389-98. PMID 23484901 DOI: 10.1021/Ja311171U  0.44
2013 Ye X, Lian Q, Eckenhoff MF, Eckenhoff RG, Pan JZ. Differential general anesthetic effects on microglial cytokine expression. Plos One. 8: e52887. PMID 23382826 DOI: 10.1371/Journal.Pone.0052887  0.44
2013 Jayakar SS, Dailey WP, Eckenhoff RG, Cohen JB. Identification of propofol binding sites in a nicotinic acetylcholine receptor with a photoreactive propofol analog. The Journal of Biological Chemistry. 288: 6178-89. PMID 23300078 DOI: 10.1074/Jbc.M112.435909  0.44
2013 Weiser BP, Kelz MB, Eckenhoff RG. In vivo activation of azipropofol prolongs anesthesia and reveals synaptic targets Journal of Biological Chemistry. 288: 1279-1285. PMID 23184948 DOI: 10.1074/Jbc.M112.413989  0.44
2013 Chitilian HV, Eckenhoff RG, Raines DE. Anesthetic drug development: Novel drugs and new approaches Surgical Neurology International. 4. DOI: 10.4103/2152-7806.109179  0.44
2012 Yuki K, Bu W, Xi J, Sen M, Shimaoka M, Eckenhoff RG. Isoflurane binds and stabilizes a closed conformation of the leukocyte function-associated antigen-1. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 4408-17. PMID 22815384 DOI: 10.1096/Fj.12-212746  0.44
2012 LeBard DN, Hénin J, Eckenhoff RG, Klein ML, Brannigan G. General anesthetics predicted to block the GLIC pore with micromolar affinity Plos Computational Biology. 8. PMID 22693438 DOI: 10.1371/Journal.Pcbi.1002532  0.44
2012 Li RQ, McKinstry AR, Moore JT, Caltagarone BM, Eckenhoff MF, Eckenhoff RG, Kelz MB. Is hydrogen sulfide-induced suspended animation general anesthesia? The Journal of Pharmacology and Experimental Therapeutics. 341: 735-42. PMID 22414854 DOI: 10.1124/Jpet.111.187237  0.44
2012 Emerson DJ, Liao Z, Eckenhoff RG, Dmochowski IJ. A novel fluorescent general anesthetic enables imaging of sites of action in vivo. Anesthesiology. 116: 1363. PMID 22373900 DOI: 10.1097/Aln.0B013E31824Cb4B1  0.44
2012 Bu W, Liu R, Cheung-Lau JC, Dmochowski IJ, Loll PJ, Eckenhoff RG. Ferritin couples iron and fatty acid metabolism. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 2394-400. PMID 22362897 DOI: 10.1096/Fj.11-198853  0.44
2012 Oakley S, Vedula LS, Bu W, Meng QC, Xi J, Liu R, Eckenhoff RG, Loll PJ. Recognition of anesthetic barbiturates by a protein binding site: a high resolution structural analysis. Plos One. 7: e32070. PMID 22359658 DOI: 10.1371/Journal.Pone.0032070  0.44
2012 Cheng Y, Thomas A, Mardini F, Bianchi SL, Tang JX, Peng J, Wei H, Eckenhoff MF, Eckenhoff RG, Levy RJ. Neurodevelopmental consequences of sub-clinical carbon monoxide exposure in newborn mice. Plos One. 7: e32029. PMID 22348142 DOI: 10.1371/Journal.Pone.0032029  0.44
2012 Cui T, Mowrey D, Bondarenko V, Tillman T, Ma D, Landrum E, Perez-Aguilar JM, He J, Wang W, Saven JG, Eckenhoff RG, Tang P, Xu Y. NMR structure and dynamics of a designed water-soluble transmembrane domain of nicotinic acetylcholine receptor. Biochimica Et Biophysica Acta. 1818: 617-26. PMID 22155685 DOI: 10.1016/J.Bbamem.2011.11.021  0.44
2011 Tang JX, Mardini F, Caltagarone BM, Garrity ST, Li RQ, Bianchi SL, Gomes O, Laferla FM, Eckenhoff RG, Eckenhoff MF. Anesthesia in presymptomatic Alzheimer's disease: a study using the triple-transgenic mouse model. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 7: 521-531.e1. PMID 21745760 DOI: 10.1016/J.Jalz.2010.10.003  0.44
2010 Friedman EB, Sun Y, Moore JT, Hung HT, Meng QC, Perera P, Joiner WJ, Thomas SA, Eckenhoff RG, Sehgal A, Kelz MB. A conserved behavioral state barrier impedes transitions between anesthetic-induced unconsciousness and wakefulness: evidence for neural inertia. Plos One. 5: e11903. PMID 20689589 DOI: 10.1371/Journal.Pone.0011903  0.44
2010 Brannigan G, LeBard DN, Hénin J, Eckenhoff RG, Klein ML. Multiple binding sites for the general anesthetic isoflurane identified in the nicotinic acetylcholine receptor transmembrane domain Proceedings of the National Academy of Sciences of the United States of America. 107: 14122-14127. PMID 20660787 DOI: 10.1073/Pnas.1008534107  0.44
2010 Hall MA, Xi J, Lor C, Dai S, Pearce R, Dailey WP, Eckenhoff RG. m-Azipropofol (AziPm) a photoactive analogue of the intravenous general anesthetic propofol. Journal of Medicinal Chemistry. 53: 5667-75. PMID 20597506 DOI: 10.1021/Jm1004072  0.44
2010 Eckenhoff RG, Xi J, Dailey WP. Inhalational anesthetic photolabeling. Methods in Molecular Biology (Clifton, N.J.). 617: 437-43. PMID 20336439 DOI: 10.1007/978-1-60327-323-7_31  0.44
2010 Eckenhoff RG, Xi J, Shimaoka M, Bhattacharji A, Covarrubias M, Dailey WP. Azi-isoflurane, a Photolabel Analog of the Commonly Used Inhaled General Anesthetic Isoflurane. Acs Chemical Neuroscience. 1: 139-145. PMID 20228895 DOI: 10.1021/Cn900014M  0.44
2010 Zhao Y, Liang G, Chen Q, Joseph DJ, Meng Q, Eckenhoff RG, Eckenhoff MF, Wei H. Anesthetic-induced neurodegeneration mediated via inositol 1,4,5-trisphosphate receptors. The Journal of Pharmacology and Experimental Therapeutics. 333: 14-22. PMID 20086058 DOI: 10.1124/Jpet.109.161562  0.44
2010 Hénin J, Brannigan G, Dailey WP, Eckenhoff R, Klein ML. An atomistic model for simulations of the general anesthetic isoflurane. The Journal of Physical Chemistry. B. 114: 604-12. PMID 19924847 DOI: 10.1021/Jp9088035  0.44
2010 Bianchi SL, Caltagarone BM, Laferla FM, Eckenhoff RG, Kelz MB. Inhaled anesthetic potency in aged Alzheimer mice. Anesthesia and Analgesia. 110: 427-30. PMID 19820240 DOI: 10.1213/Ane.0B013E3181B5A292  0.44
2009 Lea WA, Xi J, Jadhav A, Lu L, Austin CP, Simeonov A, Eckenhoff RG. A high-throughput approach for identification of novel general anesthetics. Plos One. 4: e7150. PMID 19777064 DOI: 10.1371/Journal.Pone.0007150  0.44
2009 Vedula LS, Brannigan G, Economou NJ, Xi J, Hall MA, Liu R, Rossi MJ, Dailey WP, Grasty KC, Klein ML, Eckenhoff RG, Loll PJ. A unitary anesthetic binding site at high resolution. The Journal of Biological Chemistry. 284: 24176-84. PMID 19605349 DOI: 10.1074/Jbc.M109.017814  0.44
2009 Ebalunode JO, Dong X, Ouyang Z, Liang J, Eckenhoff RG, Zheng W. Structure-based shape pharmacophore modeling for the discovery of novel anesthetic compounds. Bioorganic & Medicinal Chemistry. 17: 5133-8. PMID 19520579 DOI: 10.1016/J.Bmc.2009.05.060  0.44
2009 Baranov D, Bickler PE, Crosby GJ, Culley DJ, Eckenhoff MF, Eckenhoff RG, Hogan KJ, Jevtovic-Todorovic V, Palotás A, Perouansky M, Planel E, Silverstein JH, Wei H, Whittington RA, Xie Z, et al. Consensus statement: First International Workshop on Anesthetics and Alzheimer's disease. Anesthesia and Analgesia. 108: 1627-30. PMID 19372347 DOI: 10.1213/Ane.0B013E318199Dc72  0.44
2009 Butts CA, Xi J, Brannigan G, Saad AA, Venkatachalan SP, Pearce RA, Klein ML, Eckenhoff RG, Dmochowski IJ. Identification of a fluorescent general anesthetic, 1-aminoanthracene. Proceedings of the National Academy of Sciences of the United States of America. 106: 6501-6. PMID 19346473 DOI: 10.1073/Pnas.0810590106  0.44
2008 Ma D, Tillman TS, Tang P, Meirovitch E, Eckenhoff R, Carnini A, Xu Y. NMR studies of a channel protein without membranes: structure and dynamics of water-solubilized KcsA. Proceedings of the National Academy of Sciences of the United States of America. 105: 16537-42. PMID 18948596 DOI: 10.1073/Pnas.0805501105  0.44
2008 Brannigan G, Hénin J, Law R, Eckenhoff R, Klein ML. Embedded cholesterol in the nicotinic acetylcholine receptor Proceedings of the National Academy of Sciences of the United States of America. 105: 14418-14423. PMID 18768796 DOI: 10.1073/Pnas.0803029105  0.44
2008 Kelz MB, Eckenhoff RG. Does it add up? Anesthesia and Analgesia. 107: 365-366. PMID 18633009 DOI: 10.1213/Ane.0B013E31817E0E5B  0.44
2008 Eckenhoff RG, Zheng W, Kelz MB. From anesthetic mechanisms research to drug discovery Clinical Pharmacology and Therapeutics. 84: 144-148. PMID 18449184 DOI: 10.1038/Clpt.2008.77  0.44
2007 Putzke C, Hanley PJ, Schlichthörl G, Preisig-Müller R, Rinné S, Anetseder M, Eckenhoff R, Berkowitz C, Vassiliou T, Wulf H, Eberhart L. Differential effects of volatile and intravenous anesthetics on the activity of human TASK-1. American Journal of Physiology. Cell Physiology. 293: C1319-26. PMID 17699638 DOI: 10.1152/Ajpcell.00100.2007  0.44
2007 Hill PA, Wei Q, Eckenhoff RG, Dmochowski IJ. Thermodynamics of xenon binding to cryptophane in water and human plasma. Journal of the American Chemical Society. 129: 9262-3. PMID 17616197 DOI: 10.1021/Ja072965P  0.44
2006 Xi J, Liu R, Rossi MJ, Yang J, Loll PJ, Dailey WP, Eckenhoff RG. Photoactive analogues of the haloether anesthetics provide high-resolution features from low-affinity interactions. Acs Chemical Biology. 1: 377-84. PMID 17163775 DOI: 10.1021/Cb600207D  0.44
2006 Fleisher LA, Eckenhoff RG. Image not living up to goal [4] Anesthesiology. 105: 626-627. PMID 16932002 DOI: 10.1097/00000542-200609000-00033  0.44
2006 Byrem WC, Armstead SC, Kobayashi S, Eckenhoff RG, Eckmann DM. A guest molecule-host cavity fitting algorithm to mine PDB for small molecule targets Biochimica Et Biophysica Acta - Proteins and Proteomics. 1764: 1320-1324. PMID 16904958 DOI: 10.1016/J.Bbapap.2006.06.009  0.44
2006 Vemparala S, Saiz L, Eckenhoff RG, Klein ML. Partitioning of anesthetics into a lipid bilayer and their interaction with membrane-bound peptide bundles. Biophysical Journal. 91: 2815-25. PMID 16877515 DOI: 10.1529/Biophysj.106.085324  0.44
2006 Pan JZ, Wei H, Hecker JG, Tobias JW, Eckenhoff RG, Eckenhoff MF. Rat brain DNA transcript profile of halothane and isoflurane exposure. Pharmacogenetics and Genomics. 16: 171-82. PMID 16495776 DOI: 10.1097/01.Fpc.0000189795.21770.08  0.44
2006 Sun Y, Chen J, Pruckmayr G, Baumgardner JE, Eckmann DM, Eckenhoff RG, Kelz MB. High throughput modular chambers for rapid evaluation of anesthetic sensitivity Bmc Anesthesiology. 6. DOI: 10.1186/1471-2253-6-13  0.44
2005 Peterlin Z, Ishizawa Y, Araneda R, Eckenhoff R, Firestein S. Selective activation of G-protein coupled receptors by volatile anesthetics. Molecular and Cellular Neurosciences. 30: 506-12. PMID 16185894 DOI: 10.1016/J.Mcn.2005.08.012  0.44
2005 Mannes AJ, Brown DC, Keller J, Cordes L, Eckenhoff RG, Caudle RM, Iadarola MJ, Meng QC. Measurement of resiniferatoxin in serum samples by high-performance liquid chromatography. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 823: 184-8. PMID 16039169 DOI: 10.1016/J.Jchromb.2005.06.042  0.44
2005 Mohr JT, Gribble GW, Lin SS, Eckenhoff RG, Cantor RS. Anesthetic potency of two novel synthetic polyhydric alkanols longer than the n-alkanol cutoff: evidence for a bilayer-mediated mechanism of anesthesia? Journal of Medicinal Chemistry. 48: 4172-6. PMID 15943489 DOI: 10.1021/Jm049459K  0.44
2005 Liu R, Eckenhoff RG. Weak Polar Interactions Confer Albumin Binding Site Selectivity for Haloether Anesthetics Anesthesiology. 102: 799-805. PMID 15791110 DOI: 10.1097/00000542-200504000-00016  0.4
2005 Liu R, Loll PJ, Eckenhoff RG. Structural basis for high-affinity volatile anesthetic binding in a natural 4-helix bundle protein. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 567-76. PMID 15791007 DOI: 10.1096/Fj.04-3171Com  0.44
2005 Liu R, Yang J, Ha CE, Bhagavan NV, Eckenhoff RG. Truncated human serum albumin retains general anaesthetic binding activity. The Biochemical Journal. 388: 39-45. PMID 15634193 DOI: 10.1042/Bj20041224  0.4
2005 Liu R, Eckenhoff RG. Interaction between Anesthetic Molecules and Their Binding Sites Must Be Far More Complex Anesthesiology. 103: 1102-1102. DOI: 10.1097/00000542-200511000-00031  0.4
2005 Eckenhoff RG, Liu R, Johansson JS, Loll PJ. The four-helix bundle: An attractive fold International Congress Series. 1283: 15-20. DOI: 10.1016/j.ics.2005.06.079  0.44
2004 Ghirlanda G, Hilcove SA, Pidikiti R, Johansson JS, Lear JD, Degrado WF, Eckenhoff RG. Volatile anesthetic modulation of oligomerization equilibria in a hexameric model peptide. Febs Letters. 578: 140-4. PMID 15581631 DOI: 10.1016/J.Febslet.2004.10.087  0.44
2004 Xi J, Liu R, Asbury GR, Eckenhoff MF, Eckenhoff RG. Inhalational Anesthetic-binding Proteins in Rat Neuronal Membranes Journal of Biological Chemistry. 279: 19628-19633. PMID 14988400 DOI: 10.1074/Jbc.M313864200  0.4
2004 Liu R, Meng Q, Xi J, Yang J, Ha CE, Bhagavan NV, Eckenhoff RG. Comparative binding character of two general anaesthetics for sites on human serum albumin. The Biochemical Journal. 380: 147-52. PMID 14759223 DOI: 10.1042/Bj20031652  0.4
2003 Chiara DC, Dangott LJ, Eckenhoff RG, Cohen JB. Identification of nicotinic acetylcholine receptor amino acids photolabeled by the volatile anesthetic halothane. Biochemistry. 42: 13457-67. PMID 14621991 DOI: 10.1021/Bi0351561  0.44
2003 Floyd TF, Clark JM, Gelfand R, Detre JA, Ratcliffe S, Guvakov D, Lambertsen CJ, Eckenhoff RG. Independent cerebral vasoconstrictive effects of hyperoxia and accompanying arterial hypocapnia at 1 ATA. Journal of Applied Physiology (Bethesda, Md. : 1985). 95: 2453-61. PMID 12937024 DOI: 10.1152/Japplphysiol.00303.2003  0.44
2002 Liu R, Pidikiti R, Ha CE, Petersen CE, Bhagavan NV, Eckenhoff RG. The role of electrostatic interactions in human serum albumin binding and stabilization by halothane. The Journal of Biological Chemistry. 277: 36373-9. PMID 12118010 DOI: 10.1074/Jbc.M205479200  0.4
2002 Eckenhoff RG, Knoll FJ, Greenblatt EP, Dailey WP. Halogenated diazirines as photolabel mimics of the inhaled haloalkane anesthetics. Journal of Medicinal Chemistry. 45: 1879-86. PMID 11960499 DOI: 10.1021/Jm0104926  0.44
2001 Eckenhoff RG, Johansson JS, Eger EI, Sonner JM, Dilger JP, Fisher DM, Evers A, Franks NP, Harris RA, Kendig JJ, Lieb WR, Yamakura T. What are "relevant" concentrations? [6] (multiple letters) Anesthesiology. 95: 1537-1539. PMID 11767771 DOI: 10.1097/00000542-200112000-00049  0.44
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