Shailesh Natvarbhai Mistry - Publications

Affiliations: 
University of Nottingham, Nottingham, England, United Kingdom 
Area:
GPCRs, medicinal chemistry, allosteric ligands, chemical biology tools

20 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Mistry SN, Marchand P, Kellam B. 27th Annual GP2A Medicinal Chemistry Conference. Pharmaceuticals (Basel, Switzerland). 12. PMID 31817636 DOI: 10.3390/Ph12040179  0.72
2019 Fyfe TJ, Kellam B, Sykes DA, Capuano B, Scammells PJ, Lane JR, Charlton SJ, Mistry SN. Structure-Kinetic Profiling of Haloperidol Analogues at the Human Dopamine D Receptor. Journal of Medicinal Chemistry. PMID 31580666 DOI: 10.1021/Acs.Jmedchem.9B00864  0.72
2019 Fyfe TJ, Kellam B, Mistry SN, Scammells PJ, Lane JR, Capuano B. Subtle modifications to a thieno[2,3-d]pyrimidine scaffold yield negative allosteric modulators and agonists of the dopamine D receptor. European Journal of Medicinal Chemistry. 168: 474-490. PMID 30849613 DOI: 10.1016/J.Ejmech.2019.01.061  0.72
2018 Fyfe TJ, Zarzycka B, Lim HD, Kellam B, Mistry SN, Katritch V, Scammells PJ, Lane JR, Capuano B. A Thieno[2,3-d]pyrimidine Scaffold is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor. Journal of Medicinal Chemistry. PMID 29683325 DOI: 10.1021/Acs.Jmedchem.7B01565  0.72
2017 Baker JG, Gardiner SM, Woolard J, Fromont C, Jadhav GP, Mistry SN, Thompson KS, Kellam B, Hill SJ, Fischer PM. Novel selective β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28400472 DOI: 10.1096/Fj.201601305R  0.72
2016 Choy KH, Shackleford DM, Malone DT, Mistry SN, Patil RT, Scammells PJ, Langmead CJ, Pantelis C, Sexton PM, Lane JR, Christopoulos A. Positive allosteric modulation of the muscarinic M1 receptor improves efficacy of antipsychotics in mouse glutamatergic deficit models of behavior. The Journal of Pharmacology and Experimental Therapeutics. PMID 27630144 DOI: 10.1124/Jpet.116.235788  0.72
2016 Emtage AL, Mistry SN, Fischer PM, Kellam B, Laughton CA. GPCRs through the keyhole: the role of protein flexibility in ligand binding to β-adrenoceptors. Journal of Biomolecular Structure & Dynamics. 1-47. PMID 27532213 DOI: 10.1080/07391102.2016.1226197  0.72
2016 Mistry SN, Lim H, Jörg M, Capuano B, Christopoulos A, Lane JR, Scammells PJ. Novel Fused Arylpyrimidinone Based Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor. Acs Chemical Neuroscience. PMID 26891194 DOI: 10.1021/Acschemneuro.6B00018  0.48
2016 Drinkwater N, Vinh NB, Mistry SN, Bamert RS, Ruggeri C, Holleran JP, Loganathan S, Paiardini A, Charman SA, Powell AK, Avery VM, McGowan S, Scammells PJ. Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. European Journal of Medicinal Chemistry. 110: 43-64. PMID 26807544 DOI: 10.1016/J.Ejmech.2016.01.015  0.48
2015 Mistry SN, Jörg M, Lim H, Vinh NB, Sexton PM, Capuano B, Christopoulos A, Lane JR, Scammells PJ. 4-Phenylpyridin-2-one Derivatives: A Novel Class of Positive Allosteric Modulator of the M1 Muscarinic Acetylcholine Receptor. Journal of Medicinal Chemistry. PMID 26624844 DOI: 10.1021/Acs.Jmedchem.5B01562  0.48
2015 Mistry SN, Shonberg J, Draper-Joyce CJ, Klein Herenbrink C, Michino M, Shi L, Christopoulos A, Capuano B, Scammells PJ, Lane JR. Discovery of a Novel Class of Negative Allosteric Modulator of the Dopamine D2 Receptor Through Fragmentation of a Bitopic Ligand. Journal of Medicinal Chemistry. 58: 6819-43. PMID 26258690 DOI: 10.1021/Acs.Jmedchem.5B00585  0.48
2015 Shonberg J, Draper-Joyce C, Mistry SN, Christopoulos A, Scammells PJ, Lane JR, Capuano B. Structure-Activity Study of N-((trans)-4-(2-(7-Cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1H-indole-2-carboxamide (SB269652), a Bitopic Ligand That Acts as a Negative Allosteric Modulator of the Dopamine D2 Receptor. Journal of Medicinal Chemistry. PMID 26052807 DOI: 10.1021/Acs.Jmedchem.5B00581  0.48
2015 Paiardini A, Bamert RS, Kannan-Sivaraman K, Drinkwater N, Mistry SN, Scammells PJ, McGowan S. Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum aminopeptidases, M1, M17 and M18. Plos One. 10: e0115859. PMID 25700165 DOI: 10.1371/Journal.Pone.0115859  0.48
2015 Cook AE, Mistry SN, Gregory KJ, Furness SG, Sexton PM, Scammells PJ, Conigrave AD, Christopoulos A, Leach K. Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics. British Journal of Pharmacology. 172: 185-200. PMID 25220431 DOI: 10.1111/Bph.12937  0.48
2014 Abdul-Ridha A, Lane JR, Mistry SN, López L, Sexton PM, Scammells PJ, Christopoulos A, Canals M. Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor. The Journal of Biological Chemistry. 289: 33701-11. PMID 25326383 DOI: 10.1074/Jbc.M114.604967  0.48
2014 Mistry SN, Drinkwater N, Ruggeri C, Sivaraman KK, Loganathan S, Fletcher S, Drag M, Paiardini A, Avery VM, Scammells PJ, McGowan S. Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors. Journal of Medicinal Chemistry. 57: 9168-83. PMID 25299353 DOI: 10.1021/Jm501323A  0.48
2014 Abdul-Ridha A, López L, Keov P, Thal DM, Mistry SN, Sexton PM, Lane JR, Canals M, Christopoulos A. Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor. The Journal of Biological Chemistry. 289: 6067-79. PMID 24443568 DOI: 10.1074/Jbc.M113.539080  0.48
2013 Mistry SN, Valant C, Sexton PM, Capuano B, Christopoulos A, Scammells PJ. Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor. Journal of Medicinal Chemistry. 56: 5151-72. PMID 23718562 DOI: 10.1021/Jm400540B  0.48
2013 Mistry SN, Baker JG, Fischer PM, Hill SJ, Gardiner SM, Kellam B. Synthesis and in vitro and in vivo characterization of highly β1-selective β-adrenoceptor partial agonists. Journal of Medicinal Chemistry. 56: 3852-65. PMID 23614528 DOI: 10.1021/Jm400348G  0.48
2011 Baker JG, Adams LA, Salchow K, Mistry SN, Middleton RJ, Hill SJ, Kellam B. Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human β-adrenoceptors. Journal of Medicinal Chemistry. 54: 6874-87. PMID 21870877 DOI: 10.1021/Jm2008562  0.48
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