Shailesh Natvarbhai Mistry - Related publications

Affiliations: 
University of Nottingham, Nottingham, England, United Kingdom 
Area:
GPCRs, medicinal chemistry, allosteric ligands, chemical biology tools
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Papke RL, Horenstein NA. Therapeutic Targeting of 7 Nicotinic Acetylcholine Receptors. Pharmacological Reviews. 73: 1118-1149. PMID 34301823 DOI: 10.1124/pharmrev.120.000097   
2021 Manoliu LCE, Martin EC, Milac AL, Spiridon L. Effective Use of Empirical Data for Virtual Screening against APJR GPCR Receptor. Molecules (Basel, Switzerland). 26. PMID 34443478 DOI: 10.3390/molecules26164894   
2021 Lee Y, Hou X, Lee JH, Nayak A, Alexander V, Sharma PK, Chang H, Phan K, Gao ZG, Jacobson KA, Choi S, Jeong LS. Subtle Chemical Changes Cross the Boundary between Agonist and Antagonist: New A Adenosine Receptor Homology Models and Structural Network Analysis Can Predict This Boundary. Journal of Medicinal Chemistry. PMID 34435786 DOI: 10.1021/acs.jmedchem.1c00239   
2021 Schaber EN, Ivanova N, Iliev S, Petrova J, Gocheva G, Madjarova G, Ivanova A. Initial Stages of Spontaneous Binding of Folate-Based Vectors to Folate Receptor-α Observed by Unbiased Molecular Dynamics. The Journal of Physical Chemistry. B. 125: 7598-7612. PMID 34247488 DOI: 10.1021/acs.jpcb.1c00488   
2021 Schaber EN, Ivanova N, Iliev S, Petrova J, Gocheva G, Madjarova G, Ivanova A. Initial Stages of Spontaneous Binding of Folate-Based Vectors to Folate Receptor-α Observed by Unbiased Molecular Dynamics. The Journal of Physical Chemistry. B. 125: 7598-7612. PMID 34247488 DOI: 10.1021/acs.jpcb.1c00488   
2021 Haider S, Pandey P, Reddy CR, Lambert JA, Chittiboyina AG. Novel Machaeriol Analogues as Modulators of Cannabinoid Receptors: Structure-Activity Relationships of (+)-Hexahydrocannabinoids and Their Isoform Selectivities. Acs Omega. 6: 20408-20421. PMID 34395989 DOI: 10.1021/acsomega.1c02413   
2021 Boritzki V, Hübner H, Allikalt A, Gmeiner P, Wöhrl BM. Optimizing the Expression of Human Dopamine Receptors in . International Journal of Molecular Sciences. 22. PMID 34445358 DOI: 10.3390/ijms22168647   
2021 Free RB, Cuoco CA, Xie B, Namkung Y, Prabhu VV, Willette BKA, Day MM, Sanchez-Soto M, Lane JR, Laporte SA, Shi L, Allen JE, Sibley DR. Pharmacological characterization of the imipridone anti-cancer drug ONC201 reveals a negative allosteric mechanism of action at the D dopamine receptor. Molecular Pharmacology. PMID 34353882 DOI: 10.1124/molpharm.121.000336   
2021 Hansen AH, Christensen HB, Pandey SK, Sergeev E, Valentini A, Dunlop J, Dedeo D, Fratta S, Hudson BD, Milligan G, Ulven T, Rexen Ulven E. Structure-Activity Relationship Explorations and Discovery of a Potent Antagonist for the Free Fatty Acid Receptor 2. Chemmedchem. PMID 34288488 DOI: 10.1002/cmdc.202100356   
2021 Okimoto R, Ino K, Ishizu K, Takamatsu H, Sakamoto K, Yuyama H, Fuji H, Someya A, Ohtake A, Ishigami T, Masuda N, Takeda M, Kajioka S, Yoshimura N. . The Journal of Pharmacology and Experimental Therapeutics. PMID 34244231 DOI: 10.1124/jpet.121.000709   
2021 Eguchi A, Ueki A, Hoshiyama J, Kuwata K, Chikaoka Y, Kawamura T, Nagatoishi S, Tsumoto K, Ueki R, Sando S. A DNA Aptamer That Inhibits the Aberrant Signaling of Fibroblast Growth Factor Receptor in Cancer Cells. Jacs Au. 1: 578-585. PMID 34467321 DOI: 10.1021/jacsau.0c00121   
2021 Rosier N, Grätz L, Schihada H, Möller J, Işbilir A, Humphrys LJ, Nagl M, Seibel U, Lohse MJ, Pockes S. A Versatile Sub-Nanomolar Fluorescent Ligand Enables NanoBRET Binding Studies and Single-Molecule Microscopy at the Histamine H Receptor. Journal of Medicinal Chemistry. PMID 34309390 DOI: 10.1021/acs.jmedchem.1c01089   
2021 Dutt Konar A, Jain AK, Gupta A, Karthikeyan C, Trivedi P. Unravelling the selectivity of 6,7 dimethyl Quinoxaline analogues for kinase inhibition: An Insight towards the development of Alzheimer's therapeutics. Chemistry & Biodiversity. PMID 34486216 DOI: 10.1002/cbdv.202100364   
2021 Budzinski J, Maschauer S, Kobayashi H, Couvineau P, Vogt H, Gmeiner P, Roggenhofer A, Prante O, Bouvier M, Weikert D. Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer. Communications Biology. 4: 1062. PMID 34508168 DOI: 10.1038/s42003-021-02574-4   
2021 Zhao X, Fu X, Yuan X, Shayiranbieke A, Xu R, Cao F, Ren J, Liang Q, Zhao X. Development and characterization of a selective chromatographic approach to the rapid discovery of ligands binding to muscarinic-3 acetylcholine receptor. Journal of Chromatography. A. 1653: 462443. PMID 34365202 DOI: 10.1016/j.chroma.2021.462443   
2021 Cong X, Maurel D, Déméné H, Vasiliauskaité-Brooks I, Hagelberger J, Peysson F, Saint-Paul J, Golebiowski J, Granier S, Sounier R. Molecular insights into the biased signaling mechanism of the μ-opioid receptor. Molecular Cell. PMID 34433090 DOI: 10.1016/j.molcel.2021.07.033   
2021 Meng Q, Fu Y, Li S, Yan Y, Duan D, Anthony DD, Zhu Y, Wu X, Qian F, Wu C. Rapid, sensitive and cost-effective determination of immune checkpoint inhibitor activity using a magnetic bead-based binding assay. Journal of Immunological Methods. 113134. PMID 34464606 DOI: 10.1016/j.jim.2021.113134   
2021 Ramesh K, Rosenbaum DM. Molecular basis for ligand modulation of the cannabinoid receptor CB1. British Journal of Pharmacology. PMID 34265078 DOI: 10.1111/bph.15627   
2021 Ramesh K, Rosenbaum DM. Molecular basis for ligand modulation of the cannabinoid receptor CB1. British Journal of Pharmacology. PMID 34265078 DOI: 10.1111/bph.15627   
2021 Nobrega JN, Raymond R, Rajji TK, Pollock BG. A calcium fluorescence assay for quantification of cholinergic receptor activity of clinical drugs in serum - comparison with radioactive methods. Journal of Pharmacological and Toxicological Methods. 107118. PMID 34481920 DOI: 10.1016/j.vascn.2021.107118   
2021 Deganutti G, Atanasio S, Rujan RM, Sexton PM, Wootten D, Reynolds CA. Exploring Ligand Binding to Calcitonin Gene-Related Peptide Receptors. Frontiers in Molecular Biosciences. 8: 720561. PMID 34513925 DOI: 10.3389/fmolb.2021.720561   
2021 Lu S, He X, Yang Z, Chai Z, Zhou S, Wang J, Rehman AU, Ni D, Pu J, Sun J, Zhang J. Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design. Nature Communications. 12: 4721. PMID 34354057 DOI: 10.1038/s41467-021-25020-9   
2021 Misganaw D. Heteromerization of dopaminergic receptors in the brain: Pharmacological implications. Pharmacological Research. 170: 105600. PMID 33836279 DOI: 10.1016/j.phrs.2021.105600   
2021 Wu N, Olechwier AM, Brunner C, Edwards PC, Tsai CJ, Tate CG, Schertler GFX, Schneider G, Deupi X, Zenobi R, Ma P. High-mass MALDI-MS unravels ligand-mediated G protein-coupling selectivity to GPCRs. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34326250 DOI: 10.1073/pnas.2024146118   
2021 Kumar R, Grinberg AV, Li H, Kuo TH, Sako D, Krishnan L, Liharska K, Li J, Grenha R, Maguire MC, Briscoe SD, Pearsall RS, Herrin BR, Suragani RNVS, Castonguay R. Functionally diverse heteromeric traps for ligands of the transforming growth factor-β superfamily. Scientific Reports. 11: 18341. PMID 34526551 DOI: 10.1038/s41598-021-97203-9   
2021 Ren X, Gelinas AD, Linehan M, Iwasaki A, Wang W, Janjic N, Marie Pyle A. Title: Evolving a RIG-I antagonist: a modified DNA aptamer mimics viral RNA. Journal of Molecular Biology. 167227. PMID 34487794 DOI: 10.1016/j.jmb.2021.167227   
2021 Sahoo CR, Paidesetty SK, Sarathbabu S, Dehury B, Senthil Kumar N, Padhy RN. Molecular dynamics simulation, synthesis and topoisomerase inhibitory actions of vanillin derivatives: a systematic computational structural integument. Journal of Biomolecular Structure & Dynamics. 1-11. PMID 34355674 DOI: 10.1080/07391102.2021.1961867   
2021 Umezu T. Identification of novel target molecules of -menthol. Heliyon. 7: e07329. PMID 34195432 DOI: 10.1016/j.heliyon.2021.e07329   
2021 Dvorácskó S, Lázár L, Fülöp F, Palkó M, Zalán Z, Penke B, Fülöp L, Tömböly C, Bogár F. Novel High Affinity Sigma-1 Receptor Ligands from Minimal Ensemble Docking-Based Virtual Screening. International Journal of Molecular Sciences. 22. PMID 34360878 DOI: 10.3390/ijms22158112   
2021 Binder P, Schnellbächer ND, Höfer T, Becker NB, Schwarz US. Optimal ligand discrimination by asymmetric dimerization and turnover of interferon receptors. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34507994 DOI: 10.1073/pnas.2103939118   
2021 Siclari JJ, Gardner KH. Two steps, one ligand: How PPARγ binds small-molecule agonists. Structure (London, England : 1993). 29: 935-936. PMID 34478635 DOI: 10.1016/j.str.2021.08.005   
2021 Kjaer VMS, Ieremias L, Daugvilaite V, Lückmann M, Frimurer TM, Ulven T, Rosenkilde MM, Våbenø J. Discovery of GPR183 Agonists Based on an Antagonist Scaffold. Chemmedchem. PMID 34270165 DOI: 10.1002/cmdc.202100301   
2021 Giubilaro J, Schuetz DA, Stepniewski TM, Namkung Y, Khoury E, Lara-Márquez M, Campbell S, Beautrait A, Armando S, Radresa O, Duchaine J, Lamarche-Vane N, Claing A, Selent J, Bouvier M, et al. Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen. Nature Communications. 12: 4688. PMID 34344896 DOI: 10.1038/s41467-021-24968-y   
2021 Baggio C, Kulinich A, Dennys CN, Rodrigo R, Meyer K, Ethell I, Pellecchia M. NMR-Guided Design of Potent and Selective EphA4 Agonistic Ligands. Journal of Medicinal Chemistry. PMID 34293864 DOI: 10.1021/acs.jmedchem.1c00608   
2021 Elsebai MF, Schoeder CT, Müller CE. Fintiamin: A diketopiperazine from the marine sponge-derived fungus Eurotium sp. Archiv Der Pharmazie. e2100206. PMID 34368995 DOI: 10.1002/ardp.202100206   
2021 Cremers GAO, Rosier BJHM, Meijs A, Tito NB, van Duijnhoven SMJ, van Eenennaam H, Albertazzi L, de Greef TFA. Determinants of Ligand-Functionalized DNA Nanostructure-Cell Interactions. Journal of the American Chemical Society. 143: 10131-10142. PMID 34180666 DOI: 10.1021/jacs.1c02298   
2021 Jha P, Chaturvedi S, Bhat R, Jain N, Mishra AK. Insights of ligand binding in modeled h5-HT receptor: homology modeling, docking, MM-GBSA, screening and molecular dynamics. Journal of Biomolecular Structure & Dynamics. 1-13. PMID 34387135 DOI: 10.1080/07391102.2021.1961865   
2021 Dilger AC, Johnson BJ, Brent P, Ellis RL. Comparison of beta-ligands used in cattle production: structures, safety, and biological effects. Journal of Animal Science. 99. PMID 34337648 DOI: 10.1093/jas/skab094   
2021 Ochiai K, Fujii S. Structure-property and structure-activity relationships of phenylferrocene derivatives as androgen receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 46: 128141. PMID 34048883 DOI: 10.1016/j.bmcl.2021.128141   
2021 Wang X, Sandberg ML, Martin AD, Negri KR, Gabrelow GB, Nampe DP, Wu ML, McElvain ME, Toledo Warshaviak D, Lee WH, Oh J, Daris ME, Chai F, Yao C, Furney J, et al. Potent, Selective CARs as Potential T-Cell Therapeutics for HPV-positive Cancers. Journal of Immunotherapy (Hagerstown, Md. : 1997). PMID 34432728 DOI: 10.1097/CJI.0000000000000386   
2021 Zhang H, Chen LN, Yang D, Mao C, Shen Q, Feng W, Shen DD, Dai A, Xie S, Zhou Y, Qin J, Sun JP, Scharf DH, Hou T, Zhou T, et al. Structural insights into ligand recognition and activation of the melanocortin-4 receptor. Cell Research. PMID 34433901 DOI: 10.1038/s41422-021-00552-3   
2021 Singh KD, Jara ZP, Harford T, Saha PP, Pardhi TR, Desnoyer R, Karnik SS. Novel allosteric ligands of the angiotensin receptor AT1R as autoantibody blockers. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34380734 DOI: 10.1073/pnas.2019126118   
2021 Iwamoto M, Masuya T, Hosose M, Tagawa K, Ishibashi T, Yoshihara E, Downes M, Evans RM, Matsushima A. Bisphenol A derivatives act as novel coactivator binding inhibitors for estrogen receptor β. The Journal of Biological Chemistry. 101173. PMID 34499926 DOI: 10.1016/j.jbc.2021.101173   
2021 Draper-Joyce CJ, Bhola R, Wang J, Bhattarai A, Nguyen ATN, Cowie-Kent I, O'Sullivan K, Chia LY, Venugopal H, Valant C, Thal DM, Wootten D, Panel N, Carlsson J, Christie MJ, et al. Positive allosteric mechanisms of adenosine A receptor-mediated analgesia. Nature. PMID 34497422 DOI: 10.1038/s41586-021-03897-2   
2021 Berthier A, Staels B, Lefebvre P. An optimized protocol with a stepwise approach to identify specific nuclear receptor ligands from cultured mammalian cells. Star Protocols. 2: 100658. PMID 34286290 DOI: 10.1016/j.xpro.2021.100658   
2021 Bednarska-Szczepaniak K, Mieczkowski A, Kierozalska A, Pavlović Saftić D, Głąbała K, Przygodzki T, Stańczyk L, Karolczak K, Watała C, Rao H, Gao ZG, Jacobson KA, Leśnikowski ZJ. Synthesis and evaluation of adenosine derivatives as A, A, A and A adenosine receptor ligands containing boron clusters as phenyl isosteres and selective A agonists. European Journal of Medicinal Chemistry. 223: 113607. PMID 34171656 DOI: 10.1016/j.ejmech.2021.113607   
2021 Mishra PM, Nandi CK. Structural Decoding of a Small Molecular Inhibitor on the Binding of SARS-CoV-2 to the ACE 2 Receptor. The Journal of Physical Chemistry. B. PMID 34297554 DOI: 10.1021/acs.jpcb.1c03294   
2021 Aly MW, Ludwig FA, Deuther-Conrad W, Brust P, Abadi AH, Moldovan RP, Osman NA. Development of fluorinated and methoxylated benzothiazole derivatives as highly potent and selective cannabinoid CB receptor ligands. Bioorganic Chemistry. 114: 105191. PMID 34375194 DOI: 10.1016/j.bioorg.2021.105191   
2021 Ben David A, Barnea A, Diamant E, Dor E, Schwartz A, Torgeman A, Zichel R. Small Molecule Receptor Binding Inhibitors with In Vivo Efficacy against Botulinum Neurotoxin Serotypes A and E. International Journal of Molecular Sciences. 22. PMID 34445283 DOI: 10.3390/ijms22168577   
2021 Müller CE, Namasivayam V. Recommended tool compounds and drugs for blocking P2X and P2Y receptors. Purinergic Signalling. PMID 34476721 DOI: 10.1007/s11302-021-09813-7