Timothy Fyfe - Related publications
Affiliations: | 2015-2019 | Pharmacy/MIPS | University of Nottingham/Monash University |
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50 most relevant papers in past 60 days:
50 most relevant papers in past 60 days:
| Year | Citation | Score | |
|---|---|---|---|
| 2021 | Free RB, Cuoco CA, Xie B, Namkung Y, Prabhu VV, Willette BKA, Day MM, Sanchez-Soto M, Lane JR, Laporte SA, Shi L, Allen JE, Sibley DR. Pharmacological characterization of the imipridone anti-cancer drug ONC201 reveals a negative allosteric mechanism of action at the D dopamine receptor. Molecular Pharmacology. PMID 34353882 DOI: 10.1124/molpharm.121.000336 | ||
| 2021 | Misganaw D. Heteromerization of dopaminergic receptors in the brain: Pharmacological implications. Pharmacological Research. 170: 105600. PMID 33836279 DOI: 10.1016/j.phrs.2021.105600 | ||
| 2021 | Lee Y, Hou X, Lee JH, Nayak A, Alexander V, Sharma PK, Chang H, Phan K, Gao ZG, Jacobson KA, Choi S, Jeong LS. Subtle Chemical Changes Cross the Boundary between Agonist and Antagonist: New A Adenosine Receptor Homology Models and Structural Network Analysis Can Predict This Boundary. Journal of Medicinal Chemistry. PMID 34435786 DOI: 10.1021/acs.jmedchem.1c00239 | ||
| 2021 | Ceyzériat K, Gloria Y, Tsartsalis S, Fossey C, Cailly T, Fabis F, Millet P, Tournier BB. Alterations in dopamine system and in its connectivity with serotonin in a rat model of Alzheimer's disease. Brain Communications. 3: fcab029. PMID 34286270 DOI: 10.1093/braincomms/fcab029 | ||
| 2021 | Haider S, Pandey P, Reddy CR, Lambert JA, Chittiboyina AG. Novel Machaeriol Analogues as Modulators of Cannabinoid Receptors: Structure-Activity Relationships of (+)-Hexahydrocannabinoids and Their Isoform Selectivities. Acs Omega. 6: 20408-20421. PMID 34395989 DOI: 10.1021/acsomega.1c02413 | ||
| 2021 | Kjaer VMS, Ieremias L, Daugvilaite V, Lückmann M, Frimurer TM, Ulven T, Rosenkilde MM, Våbenø J. Discovery of GPR183 Agonists Based on an Antagonist Scaffold. Chemmedchem. PMID 34270165 DOI: 10.1002/cmdc.202100301 | ||
| 2021 | Dutt Konar A, Jain AK, Gupta A, Karthikeyan C, Trivedi P. Unravelling the selectivity of 6,7 dimethyl Quinoxaline analogues for kinase inhibition: An Insight towards the development of Alzheimer's therapeutics. Chemistry & Biodiversity. PMID 34486216 DOI: 10.1002/cbdv.202100364 | ||
| 2021 | Rosier N, Grätz L, Schihada H, Möller J, Işbilir A, Humphrys LJ, Nagl M, Seibel U, Lohse MJ, Pockes S. A Versatile Sub-Nanomolar Fluorescent Ligand Enables NanoBRET Binding Studies and Single-Molecule Microscopy at the Histamine H Receptor. Journal of Medicinal Chemistry. PMID 34309390 DOI: 10.1021/acs.jmedchem.1c01089 | ||
| 2021 | Hansen AH, Christensen HB, Pandey SK, Sergeev E, Valentini A, Dunlop J, Dedeo D, Fratta S, Hudson BD, Milligan G, Ulven T, Rexen Ulven E. Structure-Activity Relationship Explorations and Discovery of a Potent Antagonist for the Free Fatty Acid Receptor 2. Chemmedchem. PMID 34288488 DOI: 10.1002/cmdc.202100356 | ||
| 2021 | Manoliu LCE, Martin EC, Milac AL, Spiridon L. Effective Use of Empirical Data for Virtual Screening against APJR GPCR Receptor. Molecules (Basel, Switzerland). 26. PMID 34443478 DOI: 10.3390/molecules26164894 | ||
| 2021 | Umezu T. Identification of novel target molecules of -menthol. Heliyon. 7: e07329. PMID 34195432 DOI: 10.1016/j.heliyon.2021.e07329 | ||
| 2021 | Condon AF, Robinson BG, Asad N, Dore TM, Tian L, Williams JT. The residence of synaptically released dopamine on D2 autoreceptors. Cell Reports. 36: 109465. PMID 34348146 DOI: 10.1016/j.celrep.2021.109465 | ||
| 2021 | Zhao X, Fu X, Yuan X, Shayiranbieke A, Xu R, Cao F, Ren J, Liang Q, Zhao X. Development and characterization of a selective chromatographic approach to the rapid discovery of ligands binding to muscarinic-3 acetylcholine receptor. Journal of Chromatography. A. 1653: 462443. PMID 34365202 DOI: 10.1016/j.chroma.2021.462443 | ||
| 2021 | Simpson EH, Gallo EF, Balsam PD, Javitch JA, Kellendonk C. How changes in dopamine D2 receptor levels alter striatal circuit function and motivation. Molecular Psychiatry. PMID 34385603 DOI: 10.1038/s41380-021-01253-4 | ||
| 2021 | Budzinski J, Maschauer S, Kobayashi H, Couvineau P, Vogt H, Gmeiner P, Roggenhofer A, Prante O, Bouvier M, Weikert D. Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer. Communications Biology. 4: 1062. PMID 34508168 DOI: 10.1038/s42003-021-02574-4 | ||
| 2021 | Ochiai K, Fujii S. Structure-property and structure-activity relationships of phenylferrocene derivatives as androgen receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 46: 128141. PMID 34048883 DOI: 10.1016/j.bmcl.2021.128141 | ||
| 2021 | Reynolds GP. High dose antipsychotic polypharmacy and dopamine partial agonists - time to rethink guidelines? Journal of Psychopharmacology (Oxford, England). 2698811211026456. PMID 34256637 DOI: 10.1177/02698811211026456 | ||
| 2021 | Pfeifer P, Sebastian A, Buchholz HG, Kaller CP, Gründer G, Fehr C, Schreckenberger M, Tüscher O. Prefrontal and striatal dopamine D/D receptors correlate with fMRI BOLD activation during stopping. Brain Imaging and Behavior. PMID 34403039 DOI: 10.1007/s11682-021-00491-y | ||
| 2021 | Ramesh K, Rosenbaum DM. Molecular basis for ligand modulation of the cannabinoid receptor CB1. British Journal of Pharmacology. PMID 34265078 DOI: 10.1111/bph.15627 | ||
| 2021 | Ramesh K, Rosenbaum DM. Molecular basis for ligand modulation of the cannabinoid receptor CB1. British Journal of Pharmacology. PMID 34265078 DOI: 10.1111/bph.15627 | ||
| 2021 | Dvorácskó S, Lázár L, Fülöp F, Palkó M, Zalán Z, Penke B, Fülöp L, Tömböly C, Bogár F. Novel High Affinity Sigma-1 Receptor Ligands from Minimal Ensemble Docking-Based Virtual Screening. International Journal of Molecular Sciences. 22. PMID 34360878 DOI: 10.3390/ijms22158112 | ||
| 2021 | Bednarska-Szczepaniak K, Mieczkowski A, Kierozalska A, Pavlović Saftić D, Głąbała K, Przygodzki T, Stańczyk L, Karolczak K, Watała C, Rao H, Gao ZG, Jacobson KA, Leśnikowski ZJ. Synthesis and evaluation of adenosine derivatives as A, A, A and A adenosine receptor ligands containing boron clusters as phenyl isosteres and selective A agonists. European Journal of Medicinal Chemistry. 223: 113607. PMID 34171656 DOI: 10.1016/j.ejmech.2021.113607 | ||
| 2021 | Guo M, Bakhoda A, Gao ZG, Ramsey JM, Li Y, O'Conor KA, Kelleher AC, Eisenberg SM, Kang Y, Yan X, Javdan C, Fowler JS, Rice KC, Hooker JM, Jacobson KA, et al. Discovery of Highly Potent Adenosine A Receptor Agonists: Targeting Positron Emission Tomography Probes. Acs Chemical Neuroscience. PMID 34469110 DOI: 10.1021/acschemneuro.1c00397 | ||
| 2021 | Li Y, Zeng J, Tian YH, Hou Y, Da H, Fang J, Gao K. Isolation, identification, and activity evaluation of diterpenoid alkaloids from Aconitum sinomontanum. Phytochemistry. 190: 112880. PMID 34311277 DOI: 10.1016/j.phytochem.2021.112880 | ||
| 2021 | Nirogi R, Mohammed AR, Shinde AK, Gagginapally SR, Kancharla DM, Ravella SR, Bogaraju N, Middekadi VR, Subramanian R, Palacharla RC, Benade V, Muddana N, Abraham R, Medapati RB, Thentu JB, et al. Discovery and Preclinical Characterization of Usmarapride (SUVN-D4010): A Potent, Selective 5-HT Receptor Partial Agonist for the Treatment of Cognitive Deficits Associated with Alzheimer's Disease. Journal of Medicinal Chemistry. PMID 34251799 DOI: 10.1021/acs.jmedchem.1c00703 | ||
| 2021 | Aly MW, Ludwig FA, Deuther-Conrad W, Brust P, Abadi AH, Moldovan RP, Osman NA. Development of fluorinated and methoxylated benzothiazole derivatives as highly potent and selective cannabinoid CB receptor ligands. Bioorganic Chemistry. 114: 105191. PMID 34375194 DOI: 10.1016/j.bioorg.2021.105191 | ||
| 2021 | Sahoo CR, Paidesetty SK, Sarathbabu S, Dehury B, Senthil Kumar N, Padhy RN. Molecular dynamics simulation, synthesis and topoisomerase inhibitory actions of vanillin derivatives: a systematic computational structural integument. Journal of Biomolecular Structure & Dynamics. 1-11. PMID 34355674 DOI: 10.1080/07391102.2021.1961867 | ||
| 2021 | Elsebai MF, Schoeder CT, Müller CE. Fintiamin: A diketopiperazine from the marine sponge-derived fungus Eurotium sp. Archiv Der Pharmazie. e2100206. PMID 34368995 DOI: 10.1002/ardp.202100206 | ||
| 2021 | Gonda X, Tarazi FI. Dopamine D3 Receptors: From Bench to Bedside. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet Lapja = Official Journal of the Hungarian Association of Psychopharmacology. 23: 272-280. PMID 34342419 | ||
| 2021 | Ren X, Gelinas AD, Linehan M, Iwasaki A, Wang W, Janjic N, Marie Pyle A. Title: Evolving a RIG-I antagonist: a modified DNA aptamer mimics viral RNA. Journal of Molecular Biology. 167227. PMID 34487794 DOI: 10.1016/j.jmb.2021.167227 | ||
| 2021 | Zhang H, Chen LN, Yang D, Mao C, Shen Q, Feng W, Shen DD, Dai A, Xie S, Zhou Y, Qin J, Sun JP, Scharf DH, Hou T, Zhou T, et al. Structural insights into ligand recognition and activation of the melanocortin-4 receptor. Cell Research. PMID 34433901 DOI: 10.1038/s41422-021-00552-3 | ||
| 2021 | Draper-Joyce CJ, Bhola R, Wang J, Bhattarai A, Nguyen ATN, Cowie-Kent I, O'Sullivan K, Chia LY, Venugopal H, Valant C, Thal DM, Wootten D, Panel N, Carlsson J, Christie MJ, et al. Positive allosteric mechanisms of adenosine A receptor-mediated analgesia. Nature. PMID 34497422 DOI: 10.1038/s41586-021-03897-2 | ||
| 2021 | Singh KD, Jara ZP, Harford T, Saha PP, Pardhi TR, Desnoyer R, Karnik SS. Novel allosteric ligands of the angiotensin receptor AT1R as autoantibody blockers. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34380734 DOI: 10.1073/pnas.2019126118 | ||
| 2021 | Nobrega JN, Raymond R, Rajji TK, Pollock BG. A calcium fluorescence assay for quantification of cholinergic receptor activity of clinical drugs in serum - comparison with radioactive methods. Journal of Pharmacological and Toxicological Methods. 107118. PMID 34481920 DOI: 10.1016/j.vascn.2021.107118 | ||
| 2021 | Siclari JJ, Gardner KH. Two steps, one ligand: How PPARγ binds small-molecule agonists. Structure (London, England : 1993). 29: 935-936. PMID 34478635 DOI: 10.1016/j.str.2021.08.005 | ||
| 2021 | Myers SJ, Ruppa KP, Wilson LJ, Tahirovic YA, Lyuboslavsky P, Menaldino DS, Dentmon ZW, Koszalka GW, Zaczek R, Dingledine RJ, Traynelis SF, Liotta DC. . The Journal of Pharmacology and Experimental Therapeutics. PMID 34493631 DOI: 10.1124/jpet.120.000370 | ||
| 2021 | Schaber EN, Ivanova N, Iliev S, Petrova J, Gocheva G, Madjarova G, Ivanova A. Initial Stages of Spontaneous Binding of Folate-Based Vectors to Folate Receptor-α Observed by Unbiased Molecular Dynamics. The Journal of Physical Chemistry. B. 125: 7598-7612. PMID 34247488 DOI: 10.1021/acs.jpcb.1c00488 | ||
| 2021 | Schaber EN, Ivanova N, Iliev S, Petrova J, Gocheva G, Madjarova G, Ivanova A. Initial Stages of Spontaneous Binding of Folate-Based Vectors to Folate Receptor-α Observed by Unbiased Molecular Dynamics. The Journal of Physical Chemistry. B. 125: 7598-7612. PMID 34247488 DOI: 10.1021/acs.jpcb.1c00488 | ||
| 2021 | Aspnes GE, Menhaji-Klotz E, Boehm M, Londregan AT, Lee ECY, Limberakis C, Coffey SB, Brown JA, Jones RM, Hesp KD. Discovery and Evaluation of Non-Basic Small Molecule Modulators of the Atypical Chemokine Receptor CXCR7. Bioorganic & Medicinal Chemistry Letters. 128320. PMID 34400299 DOI: 10.1016/j.bmcl.2021.128320 | ||
| 2021 | Iwamoto M, Masuya T, Hosose M, Tagawa K, Ishibashi T, Yoshihara E, Downes M, Evans RM, Matsushima A. Bisphenol A derivatives act as novel coactivator binding inhibitors for estrogen receptor β. The Journal of Biological Chemistry. 101173. PMID 34499926 DOI: 10.1016/j.jbc.2021.101173 | ||
| 2021 | Nair PC, Miners JO, McKinnon RA, Langmead CJ, Gregory KJ, Copolov D, Chan SKW, Bastiampillai T. Binding of SEP-363856 within TAAR1 and the 5HT receptor: implications for the design of novel antipsychotic drugs. Molecular Psychiatry. PMID 34376825 DOI: 10.1038/s41380-021-01250-7 | ||
| 2021 | Vitale RM, Iannotti FA, Schiano Moriello A, Tunisi L, Piscitelli F, Savopoulos R, Cristino L, De Petrocellis L, Amodeo P, Gray R, Di Marzo V. Identification and Characterization of Cannabidiol as an OX1R Antagonist by Computational and In Vitro Functional Validation. Biomolecules. 11. PMID 34439801 DOI: 10.3390/biom11081134 | ||
| 2021 | Cong X, Maurel D, Déméné H, Vasiliauskaité-Brooks I, Hagelberger J, Peysson F, Saint-Paul J, Golebiowski J, Granier S, Sounier R. Molecular insights into the biased signaling mechanism of the μ-opioid receptor. Molecular Cell. PMID 34433090 DOI: 10.1016/j.molcel.2021.07.033 | ||
| 2021 | Papke RL, Horenstein NA. Therapeutic Targeting of 7 Nicotinic Acetylcholine Receptors. Pharmacological Reviews. 73: 1118-1149. PMID 34301823 DOI: 10.1124/pharmrev.120.000097 | ||
| 2021 | Vaidya AS, Peterson FC, Eckhardt J, Xing Z, Park SY, Dejonghe W, Takeuchi J, Pri-Tal O, Faria J, Elzinga D, Volkman BF, Todoroki Y, Mosquna A, Okamoto M, Cutler SR. Click-to-lead design of a picomolar ABA receptor antagonist with potent activity in vivo. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34531324 DOI: 10.1073/pnas.2108281118 | ||
| 2021 | Dilger AC, Johnson BJ, Brent P, Ellis RL. Comparison of beta-ligands used in cattle production: structures, safety, and biological effects. Journal of Animal Science. 99. PMID 34337648 DOI: 10.1093/jas/skab094 | ||
| 2021 | Gwak J, Cha J, Lee J, Kim Y, An SA, Lee S, Moon HB, Hur J, Giesy JP, Hong S, Khim JS. Effect-directed identification of novel aryl hydrocarbon receptor-active aromatic compounds in coastal sediments collected from a highly industrialized area. The Science of the Total Environment. 803: 149969. PMID 34481160 DOI: 10.1016/j.scitotenv.2021.149969 | ||
| 2021 | Binder P, Schnellbächer ND, Höfer T, Becker NB, Schwarz US. Optimal ligand discrimination by asymmetric dimerization and turnover of interferon receptors. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34507994 DOI: 10.1073/pnas.2103939118 | ||
| 2021 | Gim HJ, Park J, Jung ME, Houk KN. Conformational dynamics of androgen receptors bound to agonists and antagonists. Scientific Reports. 11: 15887. PMID 34354111 DOI: 10.1038/s41598-021-94707-2 | ||
| 2021 | Neumann WL, Sandoval KE, Mobayen S, Minaeian M, Kukielski SG, Srabony KN, Frare R, Slater O, Farr SA, Niehoff ML, Hospital A, Kontoyianni M, Crider AM, Witt KA. Synthesis and structure-activity relationships of 3,4,5-trisubstituted-1,2,4-triazoles: high affinity and selective somatostatin receptor-4 agonists for Alzheimer's disease treatment. Rsc Medicinal Chemistry. 12: 1352-1365. PMID 34458738 DOI: 10.1039/d1md00044f |