Adam Nelson - Publications

Affiliations: 
School of Chemistry University of Leeds, Leeds, England, United Kingdom 
Website:
https://eps.leeds.ac.uk/chemistry/staff/4180/professor-adam-nelson

116 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Townley C, McMurray L, Marsden SP, Nelson A. A unified "top-down" approach for the synthesis of diverse lead-like molecular scaffolds. Bioorganic & Medicinal Chemistry Letters. 62: 128631. PMID 35181466 DOI: 10.1016/j.bmcl.2022.128631  0.36
2020 Fey N, Green AI, Tinworth CP, Warriner S, Nelson A. Computational Mapping of Dirhodium(II) Catalysts. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 32964545 DOI: 10.1002/chem.202003801  0.543
2020 Francis D, Nelson A, Marsden S. Synthesis of β-Diamine Building Blocks by Photocatalytic Hydroamination of Enecarbamates with Amines, Ammonia and N-H Heterocycles. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 32853417 DOI: 10.1002/Chem.202003562  0.414
2020 Karageorgis G, Liver S, Nelson A. Activity-directed synthesis: A flexible approach for lead generation. Chemmedchem. PMID 32734671 DOI: 10.1002/Cmdc.202000524  0.355
2020 Trindade AF, Faulkner EL, Leach AG, Nelson A, Marsden SP. Fragment-oriented synthesis: β-elaboration of cyclic amine fragments using enecarbamates as platform intermediates. Chemical Communications (Cambridge, England). PMID 32626868 DOI: 10.1039/D0Cc03934A  0.364
2020 Leggott A, Clarke JE, Chow S, Warriner SL, O'Neill AJ, Nelson A. Activity-directed expansion of a series of antibacterial agents. Chemical Communications (Cambridge, England). PMID 32538401 DOI: 10.1039/D0Cc02361B  0.617
2020 Green A, Hobor F, Tinworth C, Warriner S, Wilson A, Nelson A. Activity-directed synthesis of inhibitors of the p53/hDM2 protein-protein interaction. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 32458465 DOI: 10.1002/Chem.202002153  0.637
2020 Lowe RA, Taylor D, Chibale K, Nelson A, Marsden SP. Synthesis and evaluation of the performance of a small molecule library based on diverse tropane-related scaffolds. Bioorganic & Medicinal Chemistry. 115442. PMID 32209295 DOI: 10.1016/J.Bmc.2020.115442  0.5
2020 Gomm A, Nelson A. A radical approach to diverse meroterpenoids. Nature Chemistry. PMID 31959961 DOI: 10.1038/S41557-019-0414-7  0.378
2020 Chow S, Green AI, Arter C, Liver S, Leggott A, Trask L, Karageorgis G, Warriner S, Nelson A. Efficient Approaches for the Synthesis of Diverse α-Diazo Amides Synthesis. 52: 1695-1706. DOI: 10.1055/S-0039-1690905  0.661
2020 Green AI, Hobor F, Tinworth CP, Warriner S, Wilson AJ, Nelson A. Cover Feature: Activity‐Directed Synthesis of Inhibitors of the p53/ h DM2 Protein–Protein Interaction (Chem. Eur. J. 47/2020) Chemistry: a European Journal. 26: 10645-10645. DOI: 10.1002/Chem.202003334  0.584
2019 Mayol-Llinàs J, Chow S, Nelson A. Expansion of the structure-activity relationships of BACE1 inhibitors by harnessing diverse building blocks prepared using a unified synthetic approach. Medchemcomm. 10: 616-620. PMID 31057741 DOI: 10.1039/C9Md00085B  0.385
2019 Zhang R, McIntyre PJ, Collins PM, Foley DJ, Arter C, von Delft F, Bayliss R, Warriner S, Nelson A. Construction of a Shape-Diverse Fragment Set: Design, Synthesis and Screen against Aurora-A Kinase. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 31026091 DOI: 10.2210/Pdb6R49/Pdb  0.603
2019 Rice S, Cox DJ, Marsden SP, Nelson A. Unified synthesis of diverse building blocks for application in the discovery of bioactive small molecules Tetrahedron. 75: 130513. DOI: 10.1016/J.Tet.2019.130513  0.473
2018 Morgentin R, Dow M, Aimon A, Karageorgis G, Kalliokoski T, Roche D, Marsden S, Nelson AS. Translation of innovative chemistry into screening libraries: an exemplar partnership from the European Lead Factory. Drug Discovery Today. PMID 29753124 DOI: 10.1016/J.Drudis.2018.05.007  0.336
2018 Aimon A, Karageorgis G, Masters J, Dow M, Craven PGE, Ohsten M, Willaume A, Morgentin R, Ruiz-Llamas N, Lemoine H, Kalliokoski T, Eatherton AJ, Foley DJ, Marsden SP, Nelson A. Realisation of small molecule libraries based on frameworks distantly related to natural products. Organic & Biomolecular Chemistry. PMID 29645063 DOI: 10.1039/C8Ob00688A  0.386
2018 Hassan H, Marsden SP, Nelson A. Design and synthesis of a fragment set based on twisted bicyclic lactams. Bioorganic & Medicinal Chemistry. PMID 29502908 DOI: 10.1016/J.Bmc.2018.02.027  0.354
2017 Mayol-Llinàs J, Farnaby W, Nelson A. Modular synthesis of thirty lead-like scaffolds suitable for CNS drug discovery. Chemical Communications (Cambridge, England). PMID 29099137 DOI: 10.1039/C7Cc06078E  0.358
2017 Foley DJ, Craven PGE, Collins PM, Doveston RG, Aimon A, Talon R, Churcher I, von Delft F, Marsden SP, Nelson A. Synthesis and Demonstration of the Biological Relevance of sp(3) -rich Scaffolds Distantly Related to Natural Product Frameworks. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 28983993 DOI: 10.1002/Chem.201704169  0.424
2017 Dow M, Marchetti F, Abrahams K, Vaz L, Besra G, Warriner S, Nelson A. Modular Synthesis of Diverse Natural Product-like Macrocycles: Discovery of Hits with Antimycobacterial Activity. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 28374952 DOI: 10.1002/Chem.201701150  0.685
2017 Chow SY, Nelson A. Embarking on a Chemical Space Odyssey. Journal of Medicinal Chemistry. PMID 28339216 DOI: 10.1021/Acs.Jmedchem.7B00423  0.362
2017 Windle CL, Simmons KJ, Ault JR, Trinh CH, Nelson A, Pearson AR, Berry A. Extending enzyme molecular recognition with an expanded amino acid alphabet. Proceedings of the National Academy of Sciences of the United States of America. PMID 28196894 DOI: 10.1073/Pnas.1616816114  0.308
2017 Windle CL, Berry A, Nelson A. Aldolase-catalysed stereoselective synthesis of fluorinated small molecules. Current Opinion in Chemical Biology. 37: 33-38. PMID 28113093 DOI: 10.1016/J.Cbpa.2016.12.029  0.481
2017 Mayol-Llinas J, Nelson A, Farnaby W, Ayscough A. Assessing molecular scaffolds for CNS drug discovery. Drug Discovery Today. PMID 28111331 DOI: 10.1016/J.Drudis.2017.01.008  0.367
2016 Foley DJ, Nelson A, Marsden SP. Evaluating New Chemistry to Drive Molecular Discovery: Fit for Purpose? Angewandte Chemie (International Ed. in English). PMID 27573303 DOI: 10.1002/Anie.201604193  0.34
2016 Firth JD, Craven PG, Lilburn M, Pahl A, Marsden SP, Nelson A. A biosynthesis-inspired approach to over twenty diverse natural product-like scaffolds. Chemical Communications (Cambridge, England). PMID 27424656 DOI: 10.1039/C6Cc04662B  0.798
2016 Colomer I, Empson CJ, Craven P, Owen Z, Doveston RG, Churcher I, Marsden SP, Nelson A. A divergent synthetic approach to diverse molecular scaffolds: assessment of lead-likeness using LLAMA, an open-access computational tool. Chemical Communications (Cambridge, England). PMID 27145833 DOI: 10.1039/C6Cc03244C  0.779
2016 Howard JK, Müller M, Berry A, Nelson A. An Enantio- and Diastereoselective Chemoenzymatic Synthesis of α-Fluoro β-Hydroxy Carboxylic Esters. Angewandte Chemie (International Ed. in English). PMID 27090612 DOI: 10.1002/Anie.201602852  0.413
2016 Burslem GM, Kyle HF, Breeze AL, Edwards TA, Nelson A, Warriner SL, Wilson AJ. Towards "bionic" proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics. Chemical Communications (Cambridge, England). PMID 27009828 DOI: 10.1039/C6Cc01812B  0.574
2016 Burslem GM, Kyle HF, Prabhakaran P, Breeze AL, Edwards TA, Warriner SL, Nelson A, Wilson AJ. Synthesis of highly functionalized oligobenzamide proteomimetic foldamers by late stage introduction of sensitive groups. Organic & Biomolecular Chemistry. PMID 27005701 DOI: 10.1039/C6Ob00078A  0.645
2016 Howard JK, Müller M, Berry A, Nelson A. Biocatalytic syn-Selective Aldol Reaction of Fluoropyruvate Synfacts. 12: 741-741. DOI: 10.1055/S-0035-1562257  0.334
2015 Stockwell J, Daniels AD, Windle CL, Harman TA, Woodhall T, Lebl T, Trinh CH, Mulholland K, Pearson AR, Berry A, Nelson A. Evaluation of fluoropyruvate as nucleophile in reactions catalysed by N-acetyl neuraminic acid lyase variants: scope, limitations and stereoselectivity. Organic & Biomolecular Chemistry. PMID 26537532 DOI: 10.1039/C5Ob02037A  0.34
2015 Karageorgis G, Dow M, Aimon A, Warriner S, Nelson A. Frontispiece: Activity-Directed Synthesis with Intermolecular Reactions: Development of a Fragment into a Range of Androgen Receptor Agonists. Angewandte Chemie (International Ed. in English). 54. PMID 26523750 DOI: 10.1002/anie.201584661  0.587
2015 Karawajczyk A, Giordanetto F, Benningshof J, Hamza D, Kalliokoski T, Pouwer K, Morgentin R, Nelson A, Müller G, Piechot A, Tzalis D. Expansion of chemical space for collaborative lead generation and drug discovery: the European Lead Factory Perspective. Drug Discovery Today. 20: 1310-6. PMID 26429298 DOI: 10.1016/J.Drudis.2015.09.009  0.316
2015 Karageorgis G, Dow M, Aimon A, Warriner S, Nelson A. Activity-Directed Synthesis with Intermolecular Reactions: Development of a Fragment into a Range of Androgen Receptor Agonists. Angewandte Chemie (International Ed. in English). 54: 13538-44. PMID 26358926 DOI: 10.1002/Anie.201506944  0.679
2015 Kyle HF, Wickson KF, Stott J, Burslem GM, Breeze AL, Tiede C, Tomlinson DC, Warriner SL, Nelson A, Wilson AJ, Edwards TA. Exploration of the HIF-1α/p300 interface using peptide and Adhiron phage display technologies. Molecular Biosystems. PMID 26135796 DOI: 10.1039/C5Mb00284B  0.585
2015 Foley DJ, Doveston RG, Churcher I, Nelson A, Marsden SP. A systematic approach to diverse, lead-like scaffolds from α,α-disubstituted amino acids. Chemical Communications (Cambridge, England). PMID 26006179 DOI: 10.1039/C5Cc03002A  0.401
2015 Nelson A, Roche D. Innovative approaches to the design and synthesis of small molecule libraries. Bioorganic & Medicinal Chemistry. 23: 2613. PMID 25766626 DOI: 10.1016/J.Bmc.2015.02.046  0.38
2015 Colomer I, Adeniji O, Burslem GM, Craven P, Rasmussen MO, Willaume A, Kalliokoski T, Foster R, Marsden SP, Nelson A. Aminomethylhydroxylation of alkenes: Exploitation in the synthesis of scaffolds for small molecule libraries. Bioorganic & Medicinal Chemistry. 23: 2736-40. PMID 25740633 DOI: 10.1016/J.Bmc.2015.01.058  0.809
2015 Craven P, Aimon A, Dow M, Fleury-Bregeot N, Guilleux R, Morgentin R, Roche D, Kalliokoski T, Foster R, Marsden SP, Nelson A. Design, synthesis and decoration of molecular scaffolds for exploitation in the production of alkaloid-like libraries. Bioorganic & Medicinal Chemistry. 23: 2629-35. PMID 25600406 DOI: 10.1016/J.Bmc.2014.12.048  0.801
2015 Doveston RG, Tosatti P, Dow M, Foley DJ, Li HY, Campbell AJ, House D, Churcher I, Marsden SP, Nelson A. A unified lead-oriented synthesis of over fifty molecular scaffolds. Organic & Biomolecular Chemistry. 13: 859-65. PMID 25408068 DOI: 10.1039/C4Ob02287D  0.439
2015 Firth JD, Zhang R, Morgentin R, Guilleux R, Kalliokoski T, Warriner S, Foster R, Marsden SP, Nelson A. Exploitation of the Ugi–Joullié Reaction in the Synthesis of Libraries of Drug-Like Bicyclic Hydantoins Synthesis (Germany). DOI: 10.1055/S-0034-1378704  0.684
2014 Karageorgis G, Warriner S, Nelson A. Efficient discovery of bioactive scaffolds by activity-directed synthesis. Nature Chemistry. 6: 872-6. PMID 25242481 DOI: 10.1038/Nchem.2034  0.683
2014 Nelson A, Warriner S, Davey S. Parallels with nature. Nature Chemistry. 6: 845-6. PMID 25242468 DOI: 10.1038/Nchem.2076  0.618
2014 Li HY, Horn J, Campbell A, House D, Nelson A, Marsden SP. A convergent rhodium-catalysed asymmetric synthesis of tetrahydroquinolines. Chemical Communications (Cambridge, England). 50: 10222-4. PMID 25052422 DOI: 10.1039/C4Cc04940C  0.411
2014 Burslem GM, Kyle HF, Breeze AL, Edwards TA, Nelson A, Warriner SL, Wilson AJ. Small-molecule proteomimetic inhibitors of the HIF-1α-p300 protein-protein interaction. Chembiochem : a European Journal of Chemical Biology. 15: 1083-7. PMID 24782431 DOI: 10.1002/Cbic.201400009  0.602
2014 Windle CL, Müller M, Nelson A, Berry A. Engineering aldolases as biocatalysts. Current Opinion in Chemical Biology. 19: 25-33. PMID 24780276 DOI: 10.1016/J.Cbpa.2013.12.010  0.305
2014 James T, Maclellan P, Burslem GM, Simpson I, Grant JA, Warriner S, Sridharan V, Nelson A. A modular lead-oriented synthesis of diverse piperazine, 1,4-diazepane and 1,5-diazocane scaffolds. Organic & Biomolecular Chemistry. 12: 2584-91. PMID 24614952 DOI: 10.1039/C3Ob42512F  0.681
2014 Daniels AD, Campeotto I, van der Kamp MW, Bolt AH, Trinh CH, Phillips SE, Pearson AR, Nelson A, Mulholland AJ, Berry A. Reaction mechanism of N-acetylneuraminic acid lyase revealed by a combination of crystallography, QM/MM simulation, and mutagenesis. Acs Chemical Biology. 9: 1025-32. PMID 24521460 DOI: 10.1021/Cb500067Z  0.351
2014 Martin HL, Adams M, Higgins J, Bond J, Morrison EE, Bell SM, Warriner S, Nelson A, Tomlinson DC. High-content, high-throughput screening for the identification of cytotoxic compounds based on cell morphology and cell proliferation markers. Plos One. 9: e88338. PMID 24505478 DOI: 10.1371/Journal.Pone.0088338  0.603
2014 Fisher M, Basak R, Kalverda AP, Fishwick CW, Turnbull WB, Nelson A. Discovery of novel FabF ligands inspired by platensimycin by integrating structure-based design with diversity-oriented synthetic accessibility. Organic & Biomolecular Chemistry. 12: 486-94. PMID 24276506 DOI: 10.1039/C3Ob41975D  0.396
2014 Doveston R, Marsden S, Nelson A. Towards the realisation of lead-oriented synthesis. Drug Discovery Today. 19: 813-9. PMID 24239725 DOI: 10.1016/J.Drudis.2013.11.006  0.438
2014 Snieckus V, Jiao W, James T, Simpson I, Grant JA, Sridharan V, Nelson A. Synthesis of Piperazines via Gold-Catalyzed Cyclization of Propynyl Diamines Synfacts. 10: 139-139. DOI: 10.1055/S-0033-1340653  0.421
2013 James T, Simpson I, Grant JA, Sridharan V, Nelson A. Modular, gold-catalyzed approach to the synthesis of lead-like piperazine scaffolds. Organic Letters. 15: 6094-7. PMID 24219794 DOI: 10.1021/Ol402988S  0.483
2013 Maurya SK, Dow M, Warriner S, Nelson A. Synthesis of skeletally diverse alkaloid-like molecules: exploitation of metathesis substrates assembled from triplets of building blocks. Beilstein Journal of Organic Chemistry. 9: 775-85. PMID 23766790 DOI: 10.3762/Bjoc.9.88  0.659
2013 MacLellan P, Nelson A. A conceptual framework for analysing and planning synthetic approaches to diverse lead-like scaffolds. Chemical Communications (Cambridge, England). 49: 2383-93. PMID 23321958 DOI: 10.1039/C2Cc38184B  0.325
2012 Tosatti P, Nelson A, Marsden SP. Recent advances and applications of iridium-catalysed asymmetric allylic substitution. Organic & Biomolecular Chemistry. 10: 3147-63. PMID 22407450 DOI: 10.1039/C2Ob07086C  0.434
2012 Joce C, White R, Stockley PG, Warriner S, Turnbull WB, Nelson A. Design, synthesis and in vitro evaluation of novel bivalent S-adenosylmethionine analogues. Bioorganic & Medicinal Chemistry Letters. 22: 278-84. PMID 22137339 DOI: 10.1016/J.Bmcl.2011.11.017  0.593
2012 Dow M, Fisher M, James T, Marchetti F, Nelson A. Towards the systematic exploration of chemical space. Organic & Biomolecular Chemistry. 10: 17-28. PMID 21969064 DOI: 10.1039/C1Ob06098H  0.375
2012 Kinnell A, Harman T, Bingham M, Berry A, Nelson A. Development of an organo- and enzyme-catalysed one-pot, sequential three-component reaction Tetrahedron. 68: 7719-7722. DOI: 10.1016/J.Tet.2012.02.010  0.339
2011 Tosatti P, Campbell AJ, House D, Nelson A, Marsden SP. Catalyst control in sequential asymmetric allylic substitution: stereodivergent access to N,N-diprotected unnatural amino acids. The Journal of Organic Chemistry. 76: 5495-501. PMID 21563816 DOI: 10.1021/Jo200720C  0.379
2011 Tosatti P, Campbell AJ, House D, Nelson A, Marsden SP. Catalytic Asymmetric Synthesis of Unnatural Amino Acids Synfacts. 2011: 966-966. DOI: 10.1055/S-0030-1260908  0.329
2011 Murrison S, Maurya SK, Einzinger C, McKeever-Abbas B, Warriner S, Nelson A. Synthesis of Skeletally Diverse Alkaloid‐Like Small Molecules European Journal of Organic Chemistry. 2011: 2354-2359. DOI: 10.1002/Ejoc.201100116  0.685
2010 O'Leary-Steele C, Pedersen PJ, James T, Lanyon-Hogg T, Leach S, Hayes J, Nelson A. Synthesis of small molecules with high scaffold diversity: exploitation of metathesis cascades in combination with inter- and intramolecular Diels-Alder reactions. Chemistry (Weinheim An Der Bergstrasse, Germany). 16: 9563-71. PMID 20521288 DOI: 10.1002/Chem.201000707  0.47
2010 Brain CT, Chen A, Nelson A, Tanikkul N, Thomas EJ. Synthesis of macrocyclic precursors of lankacidins using Stille reactions of 4-(2-iodo-alkenyl)azetidinones and related compounds for ring closure Tetrahedron. 66: 6613-6625. DOI: 10.1016/J.Tet.2010.04.129  0.409
2010 Tosatti P, Horn J, Campbell AJ, House D, Nelson A, Marsden SP. Iridium‐Catalyzed Asymmetric Allylic Amination with Polar Amines: Access to Building Blocks with Lead‐Like Molecular Properties Advanced Synthesis & Catalysis. 352: 3153-3157. DOI: 10.1002/Adsc.201000721  0.377
2009 Joce C, Caryl J, Stockley PG, Warriner S, Nelson A. Identification of stable S-adenosylmethionine (SAM) analogues derivatised with bioorthogonal tags: effect of ligands on the affinity of the E. coli methionine repressor, MetJ, for its operator DNA. Organic & Biomolecular Chemistry. 7: 635-8. PMID 19194573 DOI: 10.1039/B816495A  0.574
2009 O'Leary-Steele C, Cordier C, Hayes J, Warriner S, Nelson A. A fluorous-tagged "safety catch" linker for preparing heterocycles by ring-closing metathesis. Organic Letters. 11: 915-8. PMID 19173645 DOI: 10.1021/Ol802848J  0.651
2009 Murrison S, Glowacki D, Einzinger C, Titchmarsh J, Bartlett S, McKeever-Abbas B, Warriner S, Nelson A. Remarkably slow rotation about a single bond between an sp(3)-hybridised carbon atom and an aromatic ring without ortho substituents. Chemistry (Weinheim An Der Bergstrasse, Germany). 15: 2185-9. PMID 19156809 DOI: 10.1002/Chem.200802127  0.598
2009 Morton D, Leach S, Cordier C, Warriner S, Nelson A. Synthesis of natural-product-like molecules with over eighty distinct scaffolds. Angewandte Chemie (International Ed. in English). 48: 104-9. PMID 19016294 DOI: 10.1002/Anie.200804486  0.659
2009 Horn J, Li HY, Marsden SP, Nelson A, Shearer RJ, Campbell AJ, House D, Weingarten GG. Convergent synthesis of dihydroquinolones from o-aminoarylboronates Tetrahedron. 65: 9002-9007. DOI: 10.1016/J.Tet.2009.06.103  0.409
2008 Horn J, Marsden SP, Nelson A, House D, Weingarten GG. Convergent, regiospecific synthesis of quinolines from o-aminophenylboronates. Organic Letters. 10: 4117-4120. PMID 18722456 DOI: 10.1021/Ol8016726  0.363
2008 Cordier C, Morton D, Murrison S, Nelson A, O'Leary-Steele C. Natural products as an inspiration in the diversity-oriented synthesis of bioactive compound libraries. Natural Product Reports. 25: 719-37. PMID 18663392 DOI: 10.1039/B706296F  0.432
2008 Cordier C, Morton D, Leach S, Woodhall T, O'Leary-Steele C, Warriner S, Nelson A. An efficient method for synthesising unsymmetrical silaketals: substrates for ring-closing, including macrocycle-closing, metathesis. Organic & Biomolecular Chemistry. 6: 1734-7. PMID 18452006 DOI: 10.1039/B804769N  0.629
2008 Leach SG, Cordier CJ, Morton D, McKiernan GJ, Warriner S, Nelson A. A fluorous-tagged linker from which small molecules are released by ring-closing metathesis. The Journal of Organic Chemistry. 73: 2753-9. PMID 18327951 DOI: 10.1021/Jo7026273  0.655
2008 Bolt A, Berry A, Nelson A. Directed evolution of aldolases for exploitation in synthetic organic chemistry. Archives of Biochemistry and Biophysics. 474: 318-30. PMID 18230325 DOI: 10.1016/J.Abb.2008.01.005  0.347
2008 Horn J, Marsden SP, Nelson A, House D, Weingarten GG. Rh-Catalyzed Conjugate Addition of o-Amino-arylboronates.Synthesis of Quinolines Synfacts. 2008: 1270-1270. DOI: 10.1055/S-0028-1087335  0.338
2007 Damiano T, Morton D, Nelson A. Photochemical transformations of pyridinium salts: mechanistic studies and applications in synthesis. Organic & Biomolecular Chemistry. 5: 2735-52. PMID 17700838 DOI: 10.1039/B706244N  0.379
2007 Dodd K, Morton D, Worden S, Narquizian R, Nelson A. Desymmetrisation of a centrosymmetric molecule by carbon-carbon bond formation: asymmetric aldol reactions of a centrosymmetric dialdehyde. Chemistry (Weinheim An Der Bergstrasse, Germany). 13: 5857-61. PMID 17458840 DOI: 10.1002/Chem.200700277  0.39
2007 Hodgson R, Kennedy A, Nelson A, Perry A. Synthesis of 3-Sulfonyloxypyridines: Oxidative Ring Expansion of α-Furyl-sulfonamides and N→O Sulfonyl Transfer Synlett. 2007: 1043-1046. DOI: 10.1055/S-2007-973875  0.315
2006 Anstiss M, Nelson A. Catalytic and stoichiometric approaches to the desymmetrisation of centrosymmetric piperazines by enantioselective acylation: a total synthesis of Dragmacidin A Organic and Biomolecular Chemistry. 4: 4135-4143. PMID 17312969 DOI: 10.1039/B608910K  0.387
2005 Kennedy A, Nelson A, Perry A. Methods for the synthesis of polyhydroxylated piperidines by diastereoselective dihydroxylation: exploitation in the two-directional synthesis of aza-C-linked disaccharide derivatives. Beilstein Journal of Organic Chemistry. 1: 2. PMID 16542015 DOI: 10.1186/1860-5397-1-2  0.363
2005 Bartlett S, Beddard GS, Jackson RM, Kayser V, Kilner C, Leach A, Nelson A, Oledzki PR, Parker P, Reid GD, Warriner SL. Comparison of the ATP binding sites of protein kinases using conformationally diverse bisindolylmaleimides. Journal of the American Chemical Society. 127: 11699-708. PMID 16104747 DOI: 10.1021/Ja050576U  0.605
2005 Barrett S, Bartlett S, Bolt A, Ironmonger A, Joce C, Nelson A, Woodhall T. Configurational stability of bisindolylmaleimide cyclophanes: from conformers to the first configurationally stable, atropisomeric bisindolylmaleimides. Chemistry (Weinheim An Der Bergstrasse, Germany). 11: 6277-85. PMID 16075446 DOI: 10.1002/Chem.200500520  0.333
2005 Ironmonger A, Stockley P, Nelson A. Asymmetric double ring-opening of a C2h-symmetric bis-epoxide: improved enantiomeric excess of the product through enantioselective desymmetrisation and ‘proof-reading’ steps Organic and Biomolecular Chemistry. 3: 2350-2353. PMID 16010371 DOI: 10.1039/B504972E  0.417
2005 Williams GJ, Woodhall T, Nelson A, Berry A. Structure-guided saturation mutagenesis of N-acetylneuraminic acid lyase for the synthesis of sialic acid mimetics. Protein Engineering, Design & Selection : Peds. 18: 239-46. PMID 15897188 DOI: 10.1093/Protein/Gzi027  0.338
2005 Woodhall T, Williams G, Berry A, Nelson A. Creation of a tailored aldolase for the parallel synthesis of sialic acid mimetics. Angewandte Chemie (International Ed. in English). 44: 2109-12. PMID 15742315 DOI: 10.1002/Anie.200462733  0.359
2004 Bartlett S, Nelson A. Evaluation of alternative approaches for the synthesis of macrocyclic bisindolylmaleimides. Organic & Biomolecular Chemistry. 2: 2874-83. PMID 15455163 DOI: 10.1039/B405010J  0.442
2004 Hodgson R, Nelson A. A two-directional synthesis of the C58–C71 fragment of palytoxin Organic and Biomolecular Chemistry. 2: 373-386. PMID 14747866 DOI: 10.1039/B307950C  0.433
2004 Kennedy A, Nelson A, Perry A. Highly diastereoselective addition of ketone enolates to N-sulfinyl imines: Asymmetric synthesis of syn- and anti-1,3-amino alcohol derivatives Synlett. 2004: 967-970. DOI: 10.1055/S-2004-820050  0.321
2004 Nelson A. The development of strategies and methods for the synthesis of biologically active compounds New Journal of Chemistry. 28: 771-776. DOI: 10.1039/B316649J  0.403
2003 Bartlett S, Hodgson R, Holland JM, Jones M, Kilner C, Nelson A, Warriner S. Exploiting predisposition in the stereoselective synthesis of mono-, bi- and tetracyclic oxygen heterocycles: equilibration between, and trapping of, alternative di- and tetraacetals. Organic & Biomolecular Chemistry. 1: 2393-402. PMID 12945714 DOI: 10.1039/B303089J  0.643
2003 Harding M, Hodgson R, Majid T, McDowall KJ, Nelson A. A stereodivergent, two-directional synthesis of stereoisomeric C-linked disaccharide mimetics. Organic & Biomolecular Chemistry. 1: 338-49. PMID 12929429 DOI: 10.1039/B208781B  0.323
2003 Williams GJ, Domann S, Nelson A, Berry A. Modifying the stereochemistry of an enzyme-catalyzed reaction by directed evolution. Proceedings of the National Academy of Sciences of the United States of America. 100: 3143-8. PMID 12626743 DOI: 10.1073/Pnas.0635924100  0.391
2003 Holland JM, Lewis M, Nelson A. Desymmetrization of a centrosymmetric diepoxide: Efficient synthesis of a key intermediate in a total synthesis of hemibrevetoxin B Journal of Organic Chemistry. 68: 747-753. PMID 12558395 DOI: 10.1021/Jo026456B  0.466
2003 Anstiss M, Holland JM, Nelson A, Titchmarsh JR. Beyond Breaking the Mirror Plane: The Desymmetrisation of Centro­symmetric Molecules as an Efficient Strategy for Asymmetric Synthesis Synlett. 2003: 1213-1220. DOI: 10.1055/S-2003-39903  0.48
2002 Harding M, Hodgson R, Nelson A. Sequential kinetic resolution of C2-symmetric compounds as a key step in two-directional synthesis: structural requirements for efficient resolution of difuryl diols Journal of the Chemical Society-Perkin Transactions 1. 2403-2413. DOI: 10.1039/B206478B  0.358
2002 Hodgson R, Majid T, Nelson A. Desymmetrisation of meso difuryl alcohols, diols and their derivatives: complementary directed and undirected asymmetric dihydroxylation reactions Journal of the Chemical Society-Perkin Transactions 1. 1631-1643. DOI: 10.1039/B204904J  0.364
2002 Hodgson R, Majid T, Nelson A. Towards complete stereochemical control: complementary methods for the synthesis of six diastereoisomeric monosaccharide mimetics Journal of the Chemical Society-Perkin Transactions 1. 1444-1454. DOI: 10.1039/B202890E  0.414
2001 Holland JM, Lewis M, Nelson A. First Desymmetrization of a Centrosymmetric Molecule in Natural Product Synthesis: Preparation of a Key Fragment in the Synthesis of Hemibrevetoxin B. Angewandte Chemie (International Ed. in English). 40: 4082-4084. PMID 29712264 DOI: 10.1002/1521-3773(20011105)40:21<4082::Aid-Anie4082>3.0.Co;2-T  0.439
2001 Hodgson R, Mahid T, Nelson A. Directed and undirected asymmetric dihydroxylation reactions: application in the synthesis of a C-linked analogue of allolactose. Chemical Communications. 2076-7. PMID 12240170 DOI: 10.1039/B107643D  0.395
2001 Harding M, Nelson A. A general, two-directional synthesis of C-(1→6)-linked disaccharide mimetics: synthesis from non-carbohydrate based starting materials Chemical Communications. 695-696. DOI: 10.1039/B101196K  0.402
2001 Chen A, Nelson A, Tanikkul N, Thomas EJ. An approach to the total synthesis of lankacidins: synthesis of advanced macrocyclic precursors Tetrahedron Letters. 42: 1251-1254. DOI: 10.1016/S0040-4039(00)02261-9  0.46
2001 Brain CT, Chen A, Nelson A, Tanikkul N, Thomas EJ. An approach to the total synthesis of lankacidins: synthesis of the requisite building blocks Tetrahedron Letters. 42: 1247-1250. DOI: 10.1016/S0040-4039(00)02260-7  0.439
2000 Green S, Nelson A, Warriner S, Whittaker B. Synthesis and investigation of the configurational stability of some dimethylammonium borate salts Journal of the Chemical Society-Perkin Transactions 1. 4403-4408. DOI: 10.1039/B005954O  0.57
1999 Nelson A, Warren S. Stereocontrol with phosphine oxides: synthesis of optically active cyclopropyl ketones Journal of the Chemical Society-Perkin Transactions 1. 3425-3433. DOI: 10.1039/A907321C  0.4
1999 Feeder N, Hutton G, Nelson A, Warren S. Stereoselective intramolecular acylation of γ′-benzoyloxyphosphine oxides with an internal chlorotrimethylsilane trap: isolation of silylated tetrahedral intermediates Journal of the Chemical Society-Perkin Transactions 1. 3413-3424. DOI: 10.1039/A907320E  0.349
1999 Nelson A, Warren S. Control of remote stereochemistry using phosphine oxides: formal synthesis of any stereoisomer diol (RR, RS, SR or SS) bearing 1,5-related stereogenic centres across an E double bond Journal of the Chemical Society-Perkin Transactions 1. 1983-1998. DOI: 10.1039/A903371H  0.323
1999 Nelson A, Warren S. 1,3-Stereocontrol with phosphine oxides: asymmetric synthesis of all four diastereoisomers of a γ′-benzyloxy β-hydroxy phosphine oxide Journal of the Chemical Society-Perkin Transactions 1. 1963-1982. DOI: 10.1039/A903370J  0.34
1999 Mitchell HJ, Nelson A, Warren S. Strategies for the stereoselective synthesis of molecules with remote stereogenic centres across a double bond of fixed configuration Journal of the Chemical Society-Perkin Transactions 1. 1899-1914. DOI: 10.1039/A902809I  0.36
1999 Aftab T, Carter C, Hart J, Nelson A. A method for the stereospecific conversion of 1,3-diols into oxetanes Tetrahedron Letters. 40: 8679-8683. DOI: 10.1016/S0040-4039(99)01840-7  0.331
1997 Clayden J, Nelson A, Warren S. Diastereoselective reactions of optically active γ-substituted vinyl phosphine oxides Tetrahedron Letters. 38: 3471-3474. DOI: 10.1016/S0040-4039(97)00658-8  0.312
1996 Cavalla D, Guéguen C, Nelson A, O'Brien P, Russell MG, Warren S. Chiral phosphine oxides and chiral esters in stereoselective intermolecular acylation reactions of phosphine oxides Tetrahedron Letters. 37: 7465-7468. DOI: 10.1016/0040-4039(96)01612-7  0.329
1996 Nelson A, Warren S. Intramolecular acylations of γ-benzoyloxy phosphine oxides: synthesis of optically active cyclopropyl ketones Tetrahedron Letters. 37: 1501-1504. DOI: 10.1016/0040-4039(96)00049-4  0.324
1995 Eames J, Mitchell HJ, Nelson A, O’Brien P, Warren S, Wyatt P. An efficient protocol for Sharpless-style racemic dihydroxylation Journal of the Chemical Society-Perkin Transactions 1. 36: 1095-1104. DOI: 10.1039/A900277D  0.312
1995 Nelson A. Asymmetric dihydroxylations of allylic phosphine oxides Tetrahedron Letters. 36: 2681-2684. DOI: 10.1016/0040-4039(95)00335-A  0.352
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