Alan R. Saltiel - Publications

Affiliations: 
University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
diabetes, receptors, signal transduction

219 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Sun X, Seidman JS, Zhao P, Troutman TD, Spann NJ, Que X, Zhou F, Liao Z, Pasillas M, Yang X, Magida JA, Kisseleva T, Brenner DA, Downes M, Evans RM, ... Saltiel AR, et al. Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis. Cell Metabolism. PMID 31761566 DOI: 10.1016/j.cmet.2019.10.014  0.36
2019 Wang L, Mazagova M, Pan C, Yang S, Brandl K, Liu J, Reilly SM, Wang Y, Miao Z, Loomba R, Lu N, Guo Q, Liu J, Yu RT, Downes M, ... ... Saltiel AR, et al. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. Proceedings of the National Academy of Sciences of the United States of America. PMID 31289229 DOI: 10.1073/pnas.1904360116  0.52
2019 Gan X, Wilson MW, Beyett TS, Wen B, Sun D, Larsen SD, Tesmer JJG, Saltiel AR, Showalter HD. Synthesis of deuterium-labelled amlexanox and its metabolic stability against mouse, rat and human microsomes. Journal of Labelled Compounds & Radiopharmaceuticals. PMID 30828860 DOI: 10.1002/jlcr.3716  0.44
2018 Beyett TS, Gan X, Reilly SM, Gomez AV, Chang L, Tesmer JJG, Saltiel AR, Showalter HD. Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKKε for the treatment of obesity. Bioorganic & Medicinal Chemistry. PMID 30270002 DOI: 10.1016/j.bmc.2018.09.020  0.8
2018 Kim JY, Garcia-Carbonell R, Yamachika S, Zhao P, Dhar D, Loomba R, Kaufman RJ, Saltiel AR, Karin M. ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P. Cell. PMID 30220454 DOI: 10.1016/j.cell.2018.08.020  0.36
2018 Beyett TS, Gan X, Reilly SM, Chang L, Gomez AV, Saltiel AR, Showalter HD, Tesmer JJ. Carboxylic acid derivatives of amlexanox display enhanced potency towards TBK1 and IKKϵ and reveal mechanisms for selective inhibition. Molecular Pharmacology. PMID 30082428 DOI: 10.1124/mol.118.112185  0.8
2018 Skorobogatko Y, Dragan M, Cordon C, Reilly SM, Hung CW, Xia W, Zhao P, Wallace M, Lackey DE, Chen XW, Osborn O, Bogner-Strauss JG, Theodorescu D, Metallo CM, Olefsky JM, ... Saltiel AR, et al. RalA controls glucose homeostasis by regulating glucose uptake in brown fat. Proceedings of the National Academy of Sciences of the United States of America. PMID 29915037 DOI: 10.1073/pnas.1801050115  1
2018 Ahmadian M, Liu S, Reilly SM, Hah N, Fan W, Yoshihara E, Jha P, De Magalhaes Filho CD, Jacinto S, Gomez AV, Dai Y, Yu RT, Liddle C, Atkins AR, Auwerx J, ... Saltiel AR, et al. ERRγ Preserves Brown Fat Innate Thermogenic Activity. Cell Reports. 22: 2849-2859. PMID 29539415 DOI: 10.1016/j.celrep.2018.02.061  0.4
2018 Zhao P, Wong KI, Sun X, Reilly SM, Uhm M, Liao Z, Skorobogatko Y, Saltiel AR. TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue. Cell. 172: 731-743.e12. PMID 29425491 DOI: 10.1016/j.cell.2018.01.007  0.64
2017 Ichikawa T, Kita M, Matsui TS, Nagasato AI, Araki T, Chiang SH, Sezaki T, Kimura Y, Ueda K, Deguchi S, Saltiel AR, Kioka N. Vinexin family (SORBS) proteins play different roles in stiffness-sensing and contractile force generation. Journal of Cell Science. PMID 28864765 DOI: 10.1242/jcs.200691  0.84
2017 Reilly SM, Saltiel AR. Adapting to obesity with adipose tissue inflammation. Nature Reviews. Endocrinology. PMID 28799554 DOI: 10.1038/nrendo.2017.90  0.4
2017 Oral EA, Reilly SM, Gomez AV, Meral R, Butz L, Ajluni N, Chenevert TL, Korytnaya E, Neidert AH, Hench R, Rus D, Horowitz JF, Poirier B, Zhao P, Lehmann K, ... ... Saltiel AR, et al. Inhibition of IKKɛ and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes. Cell Metabolism. 26: 157-170.e7. PMID 28683283 DOI: 10.1016/j.cmet.2017.06.006  0.4
2017 Uhm M, Bazuine M, Zhao P, Chiang SH, Xiong T, Karunanithi S, Chang L, Saltiel AR. Phosphorylation of the exocyst protein Exo84 by TBK1 promotes insulin-stimulated GLUT4 trafficking. Science Signaling. 10. PMID 28325821 DOI: 10.1126/scisignal.aah5085  0.84
2016 Ceperuelo-Mallafré V, Ejarque M, Serena C, Duran X, Montori-Grau M, Rodríguez MA, Yanes O, Núñez-Roa C, Roche K, Puthanveetil P, Garrido-Sánchez L, Saez E, Tinahones FJ, Garcia-Roves PM, Gómez-Foix AM, ... Saltiel AR, et al. Adipose tissue glycogen accumulation is associated with obesity-linked inflammation in humans Molecular Metabolism. 5: 5-18. DOI: 10.1016/j.molmet.2015.10.001  1
2015 Baeza-Raja B, Sachs BD, Li P, Christian F, Vagena E, Davalos D, Le Moan N, Ryu JK, Sikorski SL, Chan JP, Scadeng M, Taylor SS, Houslay MD, Baillie GS, Saltiel AR, et al. p75 Neurotrophin Receptor Regulates Energy Balance in Obesity. Cell Reports. PMID 26748707 DOI: 10.1016/j.celrep.2015.12.028  1
2015 Maillard I, Saltiel AR. Metabolism: Inflammation keeps old mice healthy. Nature. PMID 26580010 DOI: 10.1038/nature15648  1
2015 Reilly SM, Saltiel AR. A Futile Approach to Fighting Obesity? Cell. 163: 539-40. PMID 26496598 DOI: 10.1016/j.cell.2015.10.006  1
2015 Hochberg I, Harvey I, Tran QT, Stephenson EJ, Barkan AL, Saltiel A, Chandler WF, Bridges D. Gene expression changes in subcutaneous adipose tissue due to Cushing's disease. Journal of Molecular Endocrinology. PMID 26150553 DOI: 10.1530/JME-15-0119  0.64
2015 Hochberg I, Tran QT, Barkan AL, Saltiel AR, Chandler WF, Bridges D. Gene Expression Signature in Adipose Tissue of Acromegaly Patients. Plos One. 10: e0129359. PMID 26087292 DOI: 10.1371/journal.pone.0129359  1
2015 Uhm M, Saltiel AR. White, Brown, and Beige; Type 2 Immunity Gets Hot Immunity. 42: 15-17. PMID 25607455 DOI: 10.1016/j.immuni.2015.01.001  1
2015 Buchner DA, Charrier A, Srinivasan E, Wang L, Paulsen MT, Ljungman M, Bridges D, Saltiel AR. Zinc finger protein 407 (ZFP407) regulates insulin-stimulated glucose uptake and glucose transporter 4 (Glut4) mRNA. The Journal of Biological Chemistry. 290: 6376-86. PMID 25596527 DOI: 10.1074/jbc.M114.623736  1
2015 Reilly SM, Ahmadian M, Zamarron BF, Chang L, Uhm M, Poirier B, Peng X, Krause DM, Korytnaya E, Neidert A, Liddle C, Yu RT, Lumeng CN, Oral EA, Downes M, ... ... Saltiel AR, et al. A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis. Nature Communications. 6: 6047. PMID 25581158 DOI: 10.1038/ncomms7047  1
2015 Fang S, Suh JM, Reilly SM, Yu E, Osborn O, Lackey D, Yoshihara E, Perino A, Jacinto S, Lukasheva Y, Atkins AR, Khvat A, Schnabl B, Yu RT, Brenner DA, ... ... Saltiel AR, et al. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nature Medicine. 21: 159-65. PMID 25559344 DOI: 10.1038/nm.3760  1
2015 Bridges D, Saltiel AR. Phosphoinositides: Key modulators of energy metabolism. Biochimica Et Biophysica Acta. 1851: 857-866. PMID 25463477 DOI: 10.1016/j.bbalip.2014.11.008  1
2014 Karunanithi S, Xiong T, Uhm M, Leto D, Sun J, Chen XW, Saltiel AR. A Rab10:RalA G protein cascade regulates insulin-stimulated glucose uptake in adipocytes. Molecular Biology of the Cell. 25: 3059-69. PMID 25103239 DOI: 10.1091/mbc.E14-06-1060  1
2014 Morrow AA, Alipour MA, Bridges D, Yao Z, Saltiel AR, Lee JM. The lipid kinase PI4KIIIβ is highly expressed in breast tumors and activates Akt in cooperation with Rab11a. Molecular Cancer Research : McR. 12: 1492-508. PMID 24962317 DOI: 10.1158/1541-7786.MCR-13-0604  1
2014 Reilly SM, Saltiel AR. Countering inflammatory signals in obesity Nature Immunology. 15: 410-411. PMID 24747704 DOI: 10.1038/ni.2874  1
2014 Liu S, Xu R, Gerin I, Cawthorn WP, Macdougald OA, Chen XW, Saltiel AR, Koenig RJ, Xu B. SRA regulates adipogenesis by modulating p38/JNK phosphorylation and stimulating insulin receptor gene expression and downstream signaling. Plos One. 9: e95416. PMID 24743795 DOI: 10.1371/journal.pone.0095416  1
2014 Lu B, Bridges D, Yang Y, Fisher K, Cheng A, Chang L, Meng ZX, Lin JD, Downes M, Yu RT, Liddle C, Evans RM, Saltiel AR. Metabolic crosstalk: molecular links between glycogen and lipid metabolism in obesity. Diabetes. 63: 2935-48. PMID 24722244 DOI: 10.2337/db13-1531  1
2014 Reilly SM, Saltiel AR. Obesity: A complex role for adipose tissue macrophages Nature Reviews Endocrinology. 10: 193-194. PMID 24492182 DOI: 10.1038/nrendo.2014.12  1
2014 Jin N, Mao K, Jin Y, Tevzadze G, Kauffman EJ, Park S, Bridges D, Loewith R, Saltiel AR, Klionsky DJ, Weisman LS. Roles for PI(3,5)P2 in nutrient sensing through TORC1. Molecular Biology of the Cell. 25: 1171-85. PMID 24478451 DOI: 10.1091/mbc.E14-01-0021  1
2014 Martin TD, Chen XW, Kaplan RE, Saltiel AR, Walker CL, Reiner DJ, Der CJ. Ral and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion. Molecular Cell. 53: 209-20. PMID 24389102 DOI: 10.1016/j.molcel.2013.12.004  1
2014 Wang GX, Cho KW, Uhm M, Hu CR, Li S, Cozacov Z, Xu AE, Cheng JX, Saltiel AR, Lumeng CN, Lin JD. Otopetrin 1 protects mice from obesity-associated metabolic dysfunction through attenuating adipose tissue inflammation. Diabetes. 63: 1340-52. PMID 24379350 DOI: 10.2337/db13-1139  1
2013 Mowers J, Uhm M, Reilly SM, Simon J, Leto D, Chiang SH, Chang L, Saltiel AR. Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1. Elife. 2: e01119. PMID 24368730 DOI: 10.7554/eLife.01119  1
2013 Suzuki T, Bridges D, Nakada D, Skiniotis G, Morrison SJ, Lin JD, Saltiel AR, Inoki K. Inhibition of AMPK catabolic action by GSK3. Molecular Cell. 50: 407-19. PMID 23623684 DOI: 10.1016/j.molcel.2013.03.022  1
2013 Reilly SM, Chiang SH, Decker SJ, Chang L, Uhm M, Larsen MJ, Rubin JR, Mowers J, White NM, Hochberg I, Downes M, Yu RT, Liddle C, Evans RM, Oh D, ... ... Saltiel AR, et al. An inhibitor of the protein kinases TBK1 and IKK-É› improves obesity-related metabolic dysfunctions in mice. Nature Medicine. 19: 313-21. PMID 23396211 DOI: 10.1038/nm.3082  1
2013 Leto D, Uhm M, Williams A, Chen XW, Saltiel AR. Negative regulation of the RalGAP complex by 14-3-3. The Journal of Biological Chemistry. 288: 9272-83. PMID 23386617 DOI: 10.1074/jbc.M112.426106  1
2012 Bridges D, Saltiel AR. Phosphoinositides in insulin action and diabetes. Current Topics in Microbiology and Immunology. 362: 61-85. PMID 23086413 DOI: 10.1007/978-94-007-5025-8_3  1
2012 Zolov SN, Bridges D, Zhang Y, Lee WW, Riehle E, Verma R, Lenk GM, Converso-Baran K, Weide T, Albin RL, Saltiel AR, Meisler MH, Russell MW, Weisman LS. In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P. Proceedings of the National Academy of Sciences of the United States of America. 109: 17472-7. PMID 23047693 DOI: 10.1073/pnas.1203106109  1
2012 Bridges D, Chang L, Lodhi IJ, Clark NA, Saltiel AR. TC10 is regulated by caveolin in 3T3-L1 adipocytes. Plos One. 7: e42451. PMID 22900022 DOI: 10.1371/journal.pone.0042451  1
2012 Bridges D, Ma JT, Park S, Inoki K, Weisman LS, Saltiel AR. Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1. Molecular Biology of the Cell. 23: 2955-62. PMID 22696681 DOI: 10.1091/mbc.E11-12-1034  1
2012 Saltiel AR. Insulin resistance in the defense against obesity Cell Metabolism. 15: 798-804. PMID 22682220 DOI: 10.1016/j.cmet.2012.03.001  1
2012 Leto D, Saltiel AR. Regulation of glucose transport by insulin: traffic control of GLUT4. Nature Reviews. Molecular Cell Biology. 13: 383-96. PMID 22617471 DOI: 10.1038/nrm3351  1
2012 Bridges D, Fisher K, Zolov SN, Xiong T, Inoki K, Weisman LS, Saltiel AR. Rab5 proteins regulate activation and localization of target of rapamycin complex 1. The Journal of Biological Chemistry. 287: 20913-21. PMID 22547071 DOI: 10.1074/jbc.M111.334060  1
2012 Baeza-Raja B, Li P, Le Moan N, Sachs BD, Schachtrup C, Davalos D, Vagena E, Bridges D, Kim C, Saltiel AR, Olefsky JM, Akassoglou K. p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity. Proceedings of the National Academy of Sciences of the United States of America. 109: 5838-43. PMID 22460790 DOI: 10.1073/pnas.1103638109  1
2012 Klionsky DJ, Saltiel AR. Autophagy works out Cell Metabolism. 15: 273-274. DOI: 10.1016/j.cmet.2012.02.008  1
2011 Li S, Chen XW, Yu L, Saltiel AR, Lin JD. Circadian metabolic regulation through crosstalk between casein kinase 1δ and transcriptional coactivator PGC-1α. Molecular Endocrinology (Baltimore, Md.). 25: 2084-93. PMID 22052997 DOI: 10.1210/me.2011-1227  1
2011 Chen XW, Saltiel AR. Ral's engagement with the exocyst: breaking up is hard to do. Cell Cycle (Georgetown, Tex.). 10: 2299-304. PMID 21654196 DOI: 10.4161/cc.10.14.16524  1
2011 Lumeng CN, Saltiel AR. Inflammatory links between obesity and metabolic disease. The Journal of Clinical Investigation. 121: 2111-7. PMID 21633179 DOI: 10.1172/JCI57132  1
2011 Chen XW, Leto D, Xiao J, Goss J, Wang Q, Shavit JA, Xiong T, Yu G, Ginsburg D, Toomre D, Xu Z, Saltiel AR. Exocyst function is regulated by effector phosphorylation. Nature Cell Biology. 13: 580-8. PMID 21516108 DOI: 10.1038/ncb2226  1
2011 Chen XW, Leto D, Xiong T, Yu G, Cheng A, Decker S, Saltiel AR. A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action. Molecular Biology of the Cell. 22: 141-52. PMID 21148297 DOI: 10.1091/mbc.E10-08-0665  1
2011 Saltiel AR. Derepressing nuclear receptors for metabolic adaptation Cell. 147: 717-718. DOI: 10.1016/j.cell.2011.10.027  1
2010 Saltiel AR. Fishing Out a Sensor for Anti-inflammatory Oils Cell. 142: 672-674. DOI: 10.1016/j.cell.2010.08.022  1
2009 Westcott DJ, Delproposto JB, Geletka LM, Wang T, Singer K, Saltiel AR, Lumeng CN. MGL1 promotes adipose tissue inflammation and insulin resistance by regulating 7/4hi monocytes in obesity. The Journal of Experimental Medicine. 206: 3143-56. PMID 19995956 DOI: 10.1084/jem.20091333  1
2009 Chiang SH, Bazuine M, Lumeng CN, Geletka LM, Mowers J, White NM, Ma JT, Zhou J, Qi N, Westcott D, Delproposto JB, Blackwell TS, Yull FE, Saltiel AR. The protein kinase IKKepsilon regulates energy balance in obese mice. Cell. 138: 961-75. PMID 19737522 DOI: 10.1016/j.cell.2009.06.046  1
2009 Lumeng CN, Maillard I, Saltiel AR. T-ing up inflammation in fat. Nature Medicine. 15: 846-7. PMID 19661987 DOI: 10.1038/nm0809-846  1
2009 Xiao J, Chen XW, Davies BA, Saltiel AR, Katzmann DJ, Xu Z. Structural basis of Ist1 function and Ist1-Did2 interaction in the multivesicular body pathway and cytokinesis. Molecular Biology of the Cell. 20: 3514-24. PMID 19477918 DOI: 10.1091/mbc.E09-05-0403  1
2009 Cheng A, Zhang M, Okubo M, Omichi K, Saltiel AR. Distinct mutations in the glycogen debranching enzyme found in glycogen storage disease type III lead to impairment in diverse cellular functions Human Molecular Genetics. 18: 2045-2052. PMID 19299494 DOI: 10.1093/hmg/ddp128  1
2009 Cheng A, Saltiel AR. Von Gierke's disease adopts an orphan (and its partner) Science Signaling. 2: pe8. PMID 19224896 DOI: 10.1126/scisignal.258pe8  1
2008 Barrett SD, Bridges AJ, Dudley DT, Saltiel AR, Fergus JH, Flamme CM, Delaney AM, Kaufman M, LePage S, Leopold WR, Przybranowski SA, Sebolt-Leopold J, Van Becelaere K, Doherty AM, Kennedy RM, et al. The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901. Bioorganic & Medicinal Chemistry Letters. 18: 6501-4. PMID 18952427 DOI: 10.1016/j.bmcl.2008.10.054  1
2008 Lumeng CN, DelProposto JB, Westcott DJ, Saltiel AR. Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes. Diabetes. 57: 3239-46. PMID 18829989 DOI: 10.2337/db08-0872  1
2008 Lodhi IJ, Bridges D, Chiang SH, Zhang Y, Cheng A, Geletka LM, Weisman LS, Saltiel AR. Insulin stimulates phosphatidylinositol 3-phosphate production via the activation of Rab5. Molecular Biology of the Cell. 19: 2718-28. PMID 18434594 DOI: 10.1091/mbc.E08-01-0105  1
2007 Cheng A, Zhang M, Gentry MS, Worby CA, Dixon JE, Saltiel AR. A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease. Genes & Development. 21: 2399-409. PMID 17908927 DOI: 10.1101/gad.1553207  1
2007 Zhang M, Liu J, Cheng A, DeYoung SM, Saltiel AR. Identification of CAP as a costameric protein that interacts with filamin C Molecular Biology of the Cell. 18: 4731-4740. PMID 17898075 DOI: 10.1091/mbc.E07-06-0628  1
2007 Chen XW, Leto D, Chiang SH, Wang Q, Saltiel AR. Activation of RalA is required for insulin-stimulated Glut4 trafficking to the plasma membrane via the exocyst and the motor protein Myo1c. Developmental Cell. 13: 391-404. PMID 17765682 DOI: 10.1016/j.devcel.2007.07.007  1
2007 Lesniewski LA, Hosch SE, Neels JG, de Luca C, Pashmforoush M, Lumeng CN, Chiang SH, Scadeng M, Saltiel AR, Olefsky JM. Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance. Nature Medicine. 13: 455-62. PMID 17351624 DOI: 10.1038/nm1550  1
2007 Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. The Journal of Clinical Investigation. 117: 175-84. PMID 17200717 DOI: 10.1172/JCI29881  1
2007 Chen XW, Saltiel AR. TIRFing out Studies on Glut4 Trafficking Developmental Cell. 12: 4-5. PMID 17199036 DOI: 10.1016/j.devcel.2006.12.008  1
2007 Lumeng CN, Deyoung SM, Bodzin JL, Saltiel AR. Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes. 56: 16-23. PMID 17192460 DOI: 10.2337/db06-1076  1
2007 Lodhi IJ, Chiang SH, Chang L, Vollenweider D, Watson RT, Inoue M, Pessin JE, Saltiel AR. Gapex-5, a Rab31 guanine nucleotide exchange factor that regulates Glut4 trafficking in adipocytes. Cell Metabolism. 5: 59-72. PMID 17189207 DOI: 10.1016/j.cmet.2006.12.006  1
2007 Chang L, Chiang SH, Saltiel AR. TC10α is required for insulin-stimulated glucose uptake in adipocytes Endocrinology. 148: 27-33. PMID 17008399 DOI: 10.1210/en.2006-1167  1
2007 Lumeng CN, Deyoung SM, Saltiel AR. Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins. American Journal of Physiology. Endocrinology and Metabolism. 292: E166-74. PMID 16926380 DOI: 10.1152/ajpendo.00284.2006  1
2007 Watson RT, Saltiel AR, Pessin JE, Kanzaki M. Subcellular compartmentalization of insulin signaling processes and GLUT4 trafficking events Mechanisms of Insulin Action: Medical Intelligence Unit. 33-51. DOI: 10.1007/978-0-387-72204-7_2  1
2007 Saltiel AR, Pessin JE. Mechanisms of insulin action: Medical intelligence unit Mechanisms of Insulin Action: Medical Intelligence Unit. 1-214. DOI: 10.1007/978-0-387-72204-7  1
2006 Zhang M, Liu J, Cheng A, DeYoung SM, Chen X, Dold LH, Saltiel AR. CAP interacts with cytoskeletal proteins and regulates adhesion-mediated ERK activation and motility Embo Journal. 25: 5284-5293. PMID 17082770 DOI: 10.1038/sj.emboj.7601406  1
2006 Chen XW, Inoue M, Hsu SC, Saltiel AR. RalA-exocyst-dependent recycling endosome trafficking is required for the completion of cytokinesis Journal of Biological Chemistry. 281: 38609-38616. PMID 17028198 DOI: 10.1074/jbc.M512847200  1
2006 Kawase K, Nakamura T, Takaya A, Aoki K, Namikawa K, Kiyama H, Inagaki S, Takemoto H, Saltiel AR, Matsuda M. GTP Hydrolysis by the Rho Family GTPase TC10 Promotes Exocytic Vesicle Fusion Developmental Cell. 11: 411-421. PMID 16950130 DOI: 10.1016/j.devcel.2006.07.008  1
2006 Su X, Lodhi IJ, Saltiel AR, Stahl PD. Insulin-stimulated interaction between insulin receptor substrate 1 and p85α and activation of protein kinase B/Akt require Rab5 Journal of Biological Chemistry. 281: 27982-27990. PMID 16880210 DOI: 10.1074/jbc.M602873200  1
2006 Lumeng CN, Saltiel AR. Insulin htts on autophagy. Autophagy. 2: 250-3. PMID 16874093  1
2006 Chun TH, Hotary KB, Sabeh F, Saltiel AR, Allen ED, Weiss SJ. A Pericellular Collagenase Directs the 3-Dimensional Development of White Adipose Tissue Cell. 125: 577-591. PMID 16678100 DOI: 10.1016/j.cell.2006.02.050  1
2006 Cheng A, Zhang M, Crosson SM, Bao ZQ, Saltiel AR. Regulation of the mouse protein targeting to glycogen (PTG) promoter by the FoxA2 forkhead protein and by 3′,5′-cyclic adenosine 5′-monophosphate in H4IIE hepatoma cells Endocrinology. 147: 3606-3612. PMID 16627590 DOI: 10.1210/en.2005-1513  1
2006 Lazar DF, Saltiel AR. Lipid phosphatases as drug discovery targets for type 2 diabetes Nature Reviews Drug Discovery. 5: 333-342. PMID 16582877 DOI: 10.1038/nrd2007  1
2006 Inoue M, Chiang SH, Chang L, Chen XW, Saltiel AR. Compartmentalization of the exocyst complex in lipid rafts controls Glut4 vesicle tethering Molecular Biology of the Cell. 17: 2303-2311. PMID 16525015 DOI: 10.1091/mbc.E06-01-0030  1
2006 Cheng A, Saltiel AR. More TORC for the gluconeogenic engine Bioessays. 28: 231-234. PMID 16479585 DOI: 10.1002/bies.20375  1
2006 Chiang Sh, Chang L, Saltiel AR. TC10 and insulin-stimulated glucose transport Methods in Enzymology. 406: 701-714. PMID 16472699 DOI: 10.1016/S0076-6879(06)06055-1  1
2005 Liu J, DeYoung SM, Zhang M, Cheng A, Saltiel AR. Changes in integrin expression during adipocyte differentiation Cell Metabolism. 2: 165-177. PMID 16154099 DOI: 10.1016/j.cmet.2005.08.006  1
2005 Saltiel AR. Holding the line on hepatic fat Cell Metabolism. 2: 1-2. PMID 16054091 DOI: 10.1016/j.cmet.2005.06.010  1
2005 Liu J, DeYoung SM, Zhang M, Dold LH, Saltiel AR. The stomatin/prohibitin/flotillin/HflK/C domain of flotillin-1 contains distinct sequences that direct plasma membrane localization and protein interactions in 3T3-L1 adipocytes Journal of Biological Chemistry. 280: 16125-16134. PMID 15713660 DOI: 10.1074/jbc.M500940200  1
2005 Decker SJ, Saltiel AR. Staying in SHIP shape Nature Medicine. 11: 123-124. PMID 15692594 DOI: 10.1038/nm0205-123  1
2004 Chang L, Chiang SH, Saltiel AR. Insulin signaling and the regulation of glucose transport Molecular Medicine. 10: 65-71. PMID 16307172 DOI: 10.2119/2005-00029.Saltiel  1
2004 Voisine P, Ruel M, Khan TA, Bianchi C, Xu SH, Kohane I, Libermann TA, Otu H, Saltiel AR, Sellke FW. Differences in gene expression profiles of diabetic and nondiabetic patients undergoing cardiopulmonary bypass and cardioplegic arrest Circulation. 110: II280-II286. PMID 15364876 DOI: 10.1161/01.CIR.0000138974.18839.02  1
2004 Kanzaki M, Mora S, Hwang JB, Saltiel AR, Pessin JE. Atypical protein kinase C (PKCζ/λ) is a convergent downstream target of the insulin-stimulated phosphatidylinositol 3-kinase and TC10 signaling pathways Journal of Cell Biology. 164: 279-290. PMID 14734537 DOI: 10.1083/jcb.200306152  1
2003 Saltiel AR. Putting the Brakes on Insulin Signaling New England Journal of Medicine. 349: 2560-2562. PMID 14695419 DOI: 10.1056/NEJMcibr031668  1
2003 Hu J, Liu J, Ghirlando R, Saltiel AR, Hubbard SR. Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor. Molecular Cell. 12: 1379-89. PMID 14690593 DOI: 10.1016/S1097-2765(03)00487-8  1
2003 Saltiel AR, Pessin JE. Insulin signaling in microdomains of the plasma membrane Traffic. 4: 711-716. PMID 14617354 DOI: 10.1034/j.1600-0854.2003.00119.x  1
2003 Saltiel AR. A TUG on glucose transport Nature Medicine. 9: 1352. PMID 14595425 DOI: 10.1038/nm1103-1352  1
2003 Liu J, DeYoung SM, Hwang JB, O'Leary EE, Saltiel AR. The roles of Cbl-b and c-Cbl in insulin-stimulated glucose transport Journal of Biological Chemistry. 278: 36754-36762. PMID 12842890 DOI: 10.1074/jbc.M300664200  1
2003 Chiang SH, Hwang J, Legendre M, Zhang M, Kimura A, Saltiel AR. TCGAP, a multidomain Rho GTpase-activating protein involved in insulin-stimulated glucose transport Embo Journal. 22: 2679-2691. PMID 12773384 DOI: 10.1093/emboj/cdg262  1
2003 Zhang M, Kimura A, Saltiel AR. Cloning and characterization of Cbl-associated protein splicing isoforms Molecular Medicine. 9: 18-25. PMID 12765336  1
2003 Crosson SM, Khan A, Printen J, Pessin JE, Saltiel AR. PTG gene deletion causes impaired glycogen synthesis and developmental insulin resistance Journal of Clinical Investigation. 111: 1423-1432. PMID 12727934 DOI: 10.1172/JCI200317975  1
2003 Saltiel AR. Muscle or fat? Rho bridges the GAP Cell. 113: 144-145. PMID 12705863 DOI: 10.1016/S0092-8674(03)00277-0  1
2003 Inoue M, Chang L, Hwang J, Chiang SH, Saltiel AR. The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin Nature. 422: 629-633. PMID 12687004 DOI: 10.1038/nature01533  1
2003 Watson RT, Furukawa M, Chiang SH, Boeglin D, Kanzaki M, Saltiel AR, Pessin JE. The exocytotic trafficking of TC10 occurs through both classical and nonclassical secretory transport pathways in 3T3L1 adipocytes. Molecular and Cellular Biology. 23: 961-74. PMID 12529401 DOI: 10.1128/MCB.23.3.961-974.2003  1
2002 Chang L, Adams RD, Saltiel AR. The TC10-interacting protein CIP4/2 is required for insulin-stimulated Glut4 translocation in 3T3L1 adipocytes. Proceedings of the National Academy of Sciences of the United States of America. 99: 12835-40. PMID 12242347 DOI: 10.1073/pnas.202495599  1
2002 Kanzaki M, Watson RT, Hou JC, Stamnes M, Saltiel AR, Pessin JE. Small GTP-binding protein TC10 differentially regulates two distinct populations of filamentous actin in 3T3L1 adipocytes. Molecular Biology of the Cell. 13: 2334-46. PMID 12134073 DOI: 10.1091/mbc.01-10-0490  1
2002 Kimura A, Mora S, Shigematsu S, Pessin JE, Saltiel AR. The insulin receptor catalyzes the tyrosine phosphorylation of caveolin-1. Journal of Biological Chemistry. 277: 30153-30158. PMID 12036959  1
2002 Liu J, Kimura A, Baumann CA, Saltiel AR. APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes. Molecular and Cellular Biology. 22: 3599-609. PMID 11997497 DOI: 10.1128/MCB.22.11.3599-3609.2002  1
2002 Saltiel AR, Pessin JE. Insulin signaling pathways in time and space Trends in Cell Biology. 12: 65-71. PMID 11849969 DOI: 10.1016/S0962-8924(01)02207-3  1
2002 Chiang SH, Hou JC, Hwang J, Pessin JE, Saltiel AR. Cloning and functional characterization of related TC10 isoforms, a subfamily of Rho proteins involved in insulin-stimulated glucose transport Journal of Biological Chemistry. 277: 13067-13073. PMID 11821390 DOI: 10.1074/jbc.M109471200  1
2001 Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism Nature. 414: 799-806. PMID 11742412 DOI: 10.1038/414799a  1
2001 Watson RT, Shigematsu S, Chiang SH, Mora S, Kanzaki M, Macara IG, Saltiel AR, Pessin JE. Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation. The Journal of Cell Biology. 154: 829-40. PMID 11502760 DOI: 10.1083/jcb.200102078  1
2001 Kimura A, Baumann CA, Chiang SH, Saltiel AR. The sorbin homology domain: a motif for the targeting of proteins to lipid rafts. Proceedings of the National Academy of Sciences of the United States of America. 98: 9098-103. PMID 11481476 DOI: 10.1073/pnas.151252898  1
2001 Saltiel AR. You are what you secrete Nature Medicine. 7: 887-888. PMID 11479613 DOI: 10.1038/90911  1
2001 Skinner JA, Saltiel AR. Cloning and identification of MYPT3: A prenylatable myosin targetting subunit of protein phosphatase 1 Biochemical Journal. 356: 257-267. PMID 11336659 DOI: 10.1042/0264-6021:3560257  1
2001 Chiang SH, Baumann CA, Kanzaki M, Thurmond DC, Watson RT, Neudauer CL, Macara IG, Pessin JE, Saltiel AR. Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10. Nature. 410: 944-8. PMID 11309621 DOI: 10.1038/35073608  1
2001 Saltiel AR. New perspectives into the molecular pathogenesis and treatment of type 2 diabetes. Cell. 104: 517-29. PMID 11239409 DOI: 10.1016/S0092-8674(01)00239-2  1
2001 Brady MJ, Saltiel AR. The role of protein phosphatase-1 in insulin action Recent Progress in Hormone Research. 56: 157-173. PMID 11237211 DOI: 10.1210/rp.56.1.157  1
2001 Baumann CA, Saltiel AR. Spatial compartmentalization of signal transduction in insulin action. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 23: 215-22. PMID 11223878 DOI: 10.1002/1521-1878(200103)23:3<215::AID-BIES1031>3.0.CO;2-S  1
2001 Baumann CA, Brady MJ, Saltiel AR. Activation of glycogen synthase by insulin in 3T3-L1 adipocytes involves c-Cbl-associating protein (CAP)-dependent and CAP-independent signaling pathways. The Journal of Biological Chemistry. 276: 6065-8. PMID 11222622 DOI: 10.1074/jbc.C000856200  1
2000 Newgard CB, Brady MJ, O'Doherty RM, Saltiel AR. Organizing glucose disposal: emerging roles of the glycogen targeting subunits of protein phosphatase-1. Diabetes. 49: 1967-77. PMID 11117996  1
2000 Olefsky JM, Saltiel AR. PPAR gamma and the treatment of insulin resistance. Trends in Endocrinology and Metabolism: Tem. 11: 362-8. PMID 11042466 DOI: 10.1016/S1043-2760(00)00306-4  1
2000 Baumann CA, Ribon V, Kanzaki M, Thurmond DC, Mora S, Shigematsu S, Bickel PE, Pessin JE, Saltiel AR. CAP defines a second signalling pathway required for insulin-stimulated glucose transport. Nature. 407: 202-7. PMID 11001060 DOI: 10.1038/35025089  1
2000 Fong NM, Jensen TC, Shah AS, Parekh NN, Saltiel AR, Brady MJ. Identification of binding sites on protein targeting to glycogen for enzymes of glycogen metabolism. The Journal of Biological Chemistry. 275: 35034-9. PMID 10938087 DOI: 10.1074/jbc.M005541200  1
2000 Pessin JE, Saltiel AR. Signaling pathways in insulin action: molecular targets of insulin resistance. The Journal of Clinical Investigation. 106: 165-9. PMID 10903329 DOI: 10.1172/JCI10582  1
2000 Saltiel AR. Series introduction: the molecular and physiological basis of insulin resistance: emerging implications for metabolic and cardiovascular diseases. The Journal of Clinical Investigation. 106: 163-4. PMID 10903328 DOI: 10.1172/JCI10533  1
2000 Baumann CA, Chokshi N, Saltiel AR, Ribon V. Cloning and characterization of a functional peroxisome proliferator activator receptor-gamma-responsive element in the promoter of the CAP gene. The Journal of Biological Chemistry. 275: 9131-5. PMID 10734046 DOI: 10.1074/jbc.275.13.9131  1
2000 Saltiel AR. Another hormone-sensitive triglyceride lipase in fat cells? Proceedings of the National Academy of Sciences of the United States of America. 97: 535-7. PMID 10639113 DOI: 10.1073/pnas.97.2.535  1
1999 Brady MJ, Pessin JE, Saltiel AR. Spatial Compartmentalization in the Regulation of Glucose Metabolism by Insulin. Trends in Endocrinology and Metabolism: Tem. 10: 408-413. PMID 10542398 DOI: 10.1016/S1043-2760(99)00201-5  1
1999 Brady MJ, Saltiel AR. Closing in on the cause of insulin resistance and type 2 diabetes. The Journal of Clinical Investigation. 104: 675-6. PMID 10491401 DOI: 10.1172/JCI8216  1
1999 Brady MJ, Kartha PM, Aysola AA, Saltiel AR. The role of glucose metabolites in the activation and translocation of glycogen synthase by insulin in 3T3-L1 adipocytes. The Journal of Biological Chemistry. 274: 27497-504. PMID 10488084 DOI: 10.1074/jbc.274.39.27497  1
1999 Syu LJ, Saltiel AR. Lipotransin: a novel docking protein for hormone-sensitive lipase. Molecular Cell. 4: 109-15. PMID 10445032 DOI: 10.1016/S1097-2765(00)80192-6  1
1999 Sebolt-Leopold JS, Dudley DT, Herrera R, Van Becelaere K, Wiland A, Gowan RC, Tecle H, Barrett SD, Bridges A, Przybranowski S, Leopold WR, Saltiel AR. Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo. Nature Medicine. 5: 810-6. PMID 10395327 DOI: 10.1038/10533  1
1999 Min J, Okada S, Kanzaki M, Elmendorf JS, Coker KJ, Ceresa BP, Syu LJ, Noda Y, Saltiel AR, Pessin JE. Synip: a novel insulin-regulated syntaxin 4-binding protein mediating GLUT4 translocation in adipocytes. Molecular Cell. 3: 751-60. PMID 10394363 DOI: 10.1016/S1097-2765(01)80007-1  1
1999 Kao AW, Noda Y, Johnson JH, Pessin JE, Saltiel AR. Aldolase mediates the association of F-actin with the insulin-responsive glucose transporter GLUT4. The Journal of Biological Chemistry. 274: 17742-7. PMID 10364216 DOI: 10.1074/jbc.274.25.17742  1
1999 Hansen L, Fjordvang H, Rasmussen SK, Vestergaard H, Echwald SM, Hansen T, Alessi D, Shenolikar S, Saltiel AR, Barbetti F, Pedersen O. Mutational analysis of the coding regions of the genes encoding protein kinase B-alpha and -beta, phosphoinositide-dependent protein kinase-1, phosphatase targeting to glycogen, protein phosphatase inhibitor-1, and glycogenin: lessons from a search for genetic variability of the insulin-stimulated glycogen synthesis pathway of skeletal muscle in NIDDM patients. Diabetes. 48: 403-7. PMID 10334321 DOI: 10.2337/diabetes.48.2.403  1
1999 Nakashima N, Rose DW, Xiao S, Egawa K, Martin SS, Haruta T, Saltiel AR, Olefsky JM. The functional role of CrkII in actin cytoskeleton organization and mitogenesis. The Journal of Biological Chemistry. 274: 3001-8. PMID 9915838 DOI: 10.1074/jbc.274.5.3001  1
1998 Ribon V, Johnson JH, Camp HS, Saltiel AR. Thiazolidinediones and insulin resistance: peroxisome proliferatoractivated receptor gamma activation stimulates expression of the CAP gene. Proceedings of the National Academy of Sciences of the United States of America. 95: 14751-6. PMID 9843961 DOI: 10.1073/pnas.95.25.14751  1
1998 Mastick CC, Brady MJ, Printen JA, Ribon V, Saltiel AR. Spatial determinants of specificity in insulin action. Molecular and Cellular Biochemistry. 182: 65-71. PMID 9609115 DOI: 10.1023/A:1006835430797  1
1998 Brady MJ, Bourbonais FJ, Saltiel AR. The activation of glycogen synthase by insulin switches from kinase inhibition to phosphatase activation during adipogenesis in 3T3-L1 cells. The Journal of Biological Chemistry. 273: 14063-6. PMID 9603900 DOI: 10.1074/jbc.273.23.14063  1
1998 Downey GP, Butler JR, Tapper H, Fialkow L, Saltiel AR, Rubin BB, Grinstein S. Importance of MEK in neutrophil microbicidal responsiveness. Journal of Immunology (Baltimore, Md. : 1950). 160: 434-43. PMID 9552001  1
1998 Su TZ, Wang M, Oxender DL, Saltiel AR. Troglitazone increases system A amino acid transport in 3T3-L1 cells. Endocrinology. 139: 832-7. PMID 9492010 DOI: 10.1210/endo.139.3.5795  1
1998 Ribon V, Herrera R, Kay BK, Saltiel AR. A role for CAP, a novel, multifunctional Src homology 3 domain-containing protein in formation of actin stress fibers and focal adhesions. The Journal of Biological Chemistry. 273: 4073-80. PMID 9461600 DOI: 10.1074/jbc.273.7.4073  1
1998 Desdouits-Magnen J, Desdouits F, Takeda S, Syu LJ, Saltiel AR, Buxbaum JD, Czernik AJ, Nairn AC, Greengard P. Regulation of secretion of Alzheimer amyloid precursor protein by the mitogen-activated protein kinase cascade. Journal of Neurochemistry. 70: 524-30. PMID 9453546  1
1998 Su TZ, Wang M, Syu LJ, Saltiel AR, Oxender DL. Regulation of system A amino acid transport in 3T3-L1 adipocytes by insulin. The Journal of Biological Chemistry. 273: 3173-9. PMID 9452428 DOI: 10.1074/jbc.273.6.3173  1
1998 Ribon V, Printen JA, Hoffman NG, Kay BK, Saltiel AR. A novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes. Molecular and Cellular Biology. 18: 872-9. PMID 9447983  1
1998 Saltiel AR. Chapter 4 Cellular mechanisms of signal transduction for growth factors Advances in Molecular and Cellular Endocrinology. 2: 83-97. DOI: 10.1016/S1569-2566(98)80012-4  1
1997 Pircher TJ, Flores-Morales A, Mui AL, Saltiel AR, Norstedt G, Gustafsson JA, Haldosén LA. Mitogen-activated protein kinase kinase inhibition decreases growth hormone stimulated transcription mediated by STAT5. Molecular and Cellular Endocrinology. 133: 169-76. PMID 9406863 DOI: 10.1016/S0303-7207(97)00164-0  1
1997 Brady MJ, Nairn AC, Saltiel AR. The regulation of glycogen synthase by protein phosphatase 1 in 3T3-L1 adipocytes. Evidence for a potential role for DARPP-32 in insulin action. The Journal of Biological Chemistry. 272: 29698-703. PMID 9368038 DOI: 10.1074/jbc.272.47.29698  1
1997 Syu LJ, Guan KL, Saltiel AR. Inducible expression of a mutant form of MEK1 in Swiss 3T3 cells. Journal of Cellular Biochemistry. 67: 367-77. PMID 9361191 DOI: 10.1002/(SICI)1097-4644(19971201)67:3<367::AID-JCB8>3.0.CO;2-U  1
1997 Kim B, Leventhal PS, Saltiel AR, Feldman EL. Insulin-like growth factor-I-mediated neurite outgrowth in vitro requires mitogen-activated protein kinase activation. The Journal of Biological Chemistry. 272: 21268-73. PMID 9261137 DOI: 10.1074/jbc.272.34.21268  1
1997 Mastick CC, Saltiel AR. Insulin-stimulated tyrosine phosphorylation of caveolin is specific for the differentiated adipocyte phenotype in 3T3-L1 cells. The Journal of Biological Chemistry. 272: 20706-14. PMID 9252391 DOI: 10.1074/jbc.272.33.20706  1
1997 Brady MJ, Printen JA, Mastick CC, Saltiel AR. Role of protein targeting to glycogen (PTG) in the regulation of protein phosphatase-1 activity. The Journal of Biological Chemistry. 272: 20198-204. PMID 9242697 DOI: 10.1074/jbc.272.32.20198  1
1997 Ribon V, Saltiel AR. Insulin stimulates tyrosine phosphorylation of the proto-oncogene product of c-Cbl in 3T3-L1 adipocytes Biochemical Journal. 324: 839-845. PMID 9210408  1
1997 Groskopf JC, Syu LJ, Saltiel AR, Linzer DIH. Proliferin induces endothelial cell chemotaxis through a G protein- coupled, mitogen-activated protein kinase-dependent pathway Endocrinology. 138: 2835-2840. PMID 9202225 DOI: 10.1210/en.138.7.2835  1
1997 Printen JA, Brady MJ, Saltiel AR. PTG, a protein phosphate 1-binding protein with a role in glycogen metabolism Science. 275: 1475-1478. PMID 9045612 DOI: 10.1126/science.275.5305.1475  1
1997 O'Rourke CM, Davis JA, Saltiel AR, Cornicelli JA. Metabolic effects of troglitazone in the Goto-Kakizaki rat, a non-obese and normolipidemic rodent model of non-insulin-dependent diabetes mellitus Metabolism: Clinical and Experimental. 46: 192-198. PMID 9030828 DOI: 10.1016/S0026-0495(97)90301-2  1
1997 Wartmann M, Hofer P, Turowskit P, Saltiel AR, Hynes NE. Negative modulation of membrane localization of the Raf-1 protein kinase by hyperphosphorylation Journal of Biological Chemistry. 272: 3915-3923. PMID 9020094 DOI: 10.1074/jbc.272.7.3915  1
1997 Párrizas M, Saltiel AR, LeRoith D. Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3'-kinase and mitogen-activated protein kinase pathways Journal of Biological Chemistry. 272: 154-161. PMID 8995241 DOI: 10.1074/jbc.272.1.154  1
1997 Stankovic CJ, Surendran N, Lunney EA, Plummer MS, Para KS, Shahripour A, Fergus JH, Marks JS, Herrera R, Hubbell SE, Humblet C, Saltiel AR, Stewart BH, Sawyer TK. The role of 4-phosphonodifluoromethyl- and 4-phosphono-phenylalanine in the selectivity and cellular uptake of SH2 domain ligands Bioorganic and Medicinal Chemistry Letters. 7: 1909-1914. DOI: 10.1016/S0960-894X(97)00334-X  1
1997 Shahripour A, Para KS, Plummer MS, Lunney EA, Holland DR, Rubin JR, Humblet C, Fergus JH, Marks JS, Saltiel AR, Sawyer TK. Structure-based design of novel, dipeptide ligands targeting the pp60(Src) SH2 domain Bioorganic and Medicinal Chemistry Letters. 7: 1107-1112. DOI: 10.1016/S0960-894X(97)00190-X  1
1996 Saltiel AR, Sawyer TK. Targeting signal transduction in the discovery of antiproliferative drugs Chemistry and Biology. 3: 887-893. PMID 8939707  1
1996 Saltiel AR, Olefsky JM. Thiazolidinediones in the treatment of insulin resistance and type II diabetes Diabetes. 45: 1661-1669. PMID 8922349  1
1996 Martin SS, Rose DW, Saltiel AR, Klippel A, Williams LT, Olefsky JM. Phosphatidylinositol 3-kinase is necessary and sufficient for insulin- stimulated stress fiber breakdown Endocrinology. 137: 5045-5054. PMID 8895379 DOI: 10.1210/en.137.11.5045  1
1996 Seely BL, Staubs PA, Reichart DR, Berhanu P, Milarski KL, Saltiel AR, Kusari J, Olefsky JM. Protein tyrosine phosphatase 1B interacts with the activated insulin receptor Diabetes. 45: 1379-1385. PMID 8826975  1
1996 Thornton KH, Mueller WT, McConnell P, Zhu G, Saltiel AR, Thanabal V. Nuclear magnetic resonance solution structure of the growth factor receptor-bound protein 2 Src homology 2 domain. Biochemistry. 35: 11852-64. PMID 8794768 DOI: 10.1021/bi952615s  1
1996 Saltiel AR. Structural and functional roles of glycosylphosphoinositides Sub-Cellular Biochemistry. 26: 165-185. PMID 8744265  1
1996 Morrison P, Saltiel AR, Rosner MR. Role of mitogen-activated protein kinase kinase in regulation of the epidermal growth factor receptor by protein kinase C Journal of Biological Chemistry. 271: 12891-12896. PMID 8662819 DOI: 10.1074/jbc.271.22.12891  1
1996 Saltiel AR. Diverse signaling pathways in the cellular actions of insulin American Journal of Physiology - Endocrinology and Metabolism. 270: E375-E385. PMID 8638681  1
1996 Ribon V, Saltiel AR. Nerve growth factor stimulates the tyrosine phosphorylation of endogenous Crk-II and augments its association with p130Cas in PC-12 cells Journal of Biological Chemistry. 271: 7375-7380. PMID 8631760  1
1996 Sasaoka T, Langlois WJ, Bai F, Rose DW, Leitner JW, Decker SJ, Saltiel AR, Gill GN, Kobayashi M, Draznin B, Olefsky JM. Involvement of ErbB2 in the signaling pathway leading to cell cycle progression from a truncated epidermal growth factor receptor lacking the C-terminal autophosphorylation sites Journal of Biological Chemistry. 271: 8338-8344. PMID 8626530  1
1996 Holt KH, Waters SB, Okada S, Yamauchi K, Decker SJ, Saltiel AR, Motto DG, Koretzky GA, Pessin JE. Epidermal growth factor receptor targeting prevents uncoupling of the Grb2-SOS complex Journal of Biological Chemistry. 271: 8300-8306. PMID 8626525 DOI: 10.1074/jbc.271.14.8300  1
1996 Azpiazu I, Saltiel AR, DePaoli-Roach AA, Lawrence JC. Regulation of both glycogen synthase and PHAS-I by insulin in rat skeletal muscle involves mitogen-activated protein kinase-independent and rapamycin-sensitive pathways Journal of Biological Chemistry. 271: 5033-5039. PMID 8617780  1
1996 Ribon V, Hubbell S, Herrera R, Saltiel AR. The product of the cbl oncogene forms stable complexes in vivo with endogenous Crk in a tyrosine phosphorylation-dependent manner Molecular and Cellular Biology. 16: 45-52. PMID 8524328  1
1996 Shahripour A, Plummer MS, Lunney EA, Para KS, Stankovic CJ, Rubin JR, Humblet C, Fergus JH, Marks JS, Herrera R, Hubbell SE, Saltiel AR, Sawyer TK. Novel phosphotyrosine mimetics in the design of peptide ligands for pp60src SH2 domain Bioorganic and Medicinal Chemistry Letters. 6: 1209-1214. DOI: 10.1016/0960-894X(96)00208-9  1
1995 Wiese RJ, Mastick CC, Lazar DF, Saltiel AR. Activation of mitogen-activated protein kinase and phosphatidylinositol 3′-kinase is not sufficient for the hormonal stimulation of glucose uptake, lipogenesis, or glycogen synthesis in 3T3-L1 adipocytes Journal of Biological Chemistry. 270: 3442-3446. PMID 7852430  1
1995 Rani CSS, Abe A, Chang Y, Rosenzweig N, Saltiel AR, Radin NS, Shayman JA. Cell cycle arrest induced by an inhibitor of glucosylceramide synthase: Correlation with cyclin-dependent kinases Journal of Biological Chemistry. 270: 2859-2867. PMID 7852361  1
1995 Pang L, Sawada T, Decker SJ, Saltiel AR. Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor Journal of Biological Chemistry. 270: 13585-13588. PMID 7775407 DOI: 10.1074/jbc.270.23.13585  1
1995 Maclean D, Sefler AM, Zhu G, Decker SJ, Saltiel AR, Singh J, McNamara D, Dobrusin EM, Sawyer TK. Differentiation of peptide molecular recognition by phospholipase Cγ-1 Src homology-2 domain and a mutant Tyr phosphatase PTP1b(C215S) Protein Science. 4: 13-20. PMID 7773170  1
1995 Pang L, Zheng CF, Guan KL, Saltiel AR. Nerve growth factor stimulates a novel protein kinase in PC-12 cells that phosphorylates and activates mitogen-activated protein kinase kinase (MEK) Biochemical Journal. 307: 513-519. PMID 7733891  1
1995 Sawada T, Milarski KL, Saltiel AR. Expression of a Catalytically Inert SYP Blocks Activation of Map Kinase Pathway Downstream of P21ras Biochemical and Biophysical Research Communications. 214: 737-743. PMID 7677789 DOI: 10.1006/bbrc.1995.2347  1
1995 Waters SB, Holt KH, Ross SE, Syu LJ, Guan KL, Saltiel AR, Koretzky GA, Pessin JE. Desensitization of Ras activation by a feedback disassociation of the SOS-Grb2 complex Journal of Biological Chemistry. 270: 20883-20886. PMID 7673108  1
1995 Lazar DF, Wiese RJ, Brady MJ, Mastick CC, Waters SB, Yamauchi K, Pessin JE, Cuatrecasas P, Saltiel AR. Mitogen-activated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulin. The Journal of Biological Chemistry. 270: 20801-7. PMID 7657664 DOI: 10.1074/jbc.270.35.20801  1
1995 Dudley DT, Pang L, Decker SJ, Bridges AJ, Saltiel AR. A synthetic inhibitor of the mitogen-activated protein kinase cascade Proceedings of the National Academy of Sciences of the United States of America. 92: 7686-7689. PMID 7644477 DOI: 10.1073/pnas.92.17.7686  1
1995 Seely BL, Reichart DR, Staubs PA, Jhun BH, Hsu D, Maegawa H, Milarski KL, Saltiel AR, Olefsky JM. Localization of the insulin-like growth factor I receptor binding sites for the SH2 domain proteins p85, Syp, and GTPase activating protein Journal of Biological Chemistry. 270: 19151-19157. PMID 7642582 DOI: 10.1074/jbc.270.32.19151  1
1995 Lin TA, Kong X, Saltiel AR, Blackshear PJ, Lawrence JC. Control of PHAS-I by insulin in 3T3-L1 adipocytes: Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway Journal of Biological Chemistry. 270: 18531-18538. PMID 7629182  1
1995 Yamauchi K, Ribon V, Saltiel AR, Pessin JE. Identification of the major SHPTP2-binding protein that is tyrosine-phosphorylated in response to insulin Journal of Biological Chemistry. 270: 17716-17722. PMID 7629070  1
1995 Langlois WJ, Sasaoka T, Saltiel AR, Olefsky JM. Negative feedback regulation and desensitization of insulin-and epidermal growth factor-stimulated p21ras activation Journal of Biological Chemistry. 270: 25320-25323. PMID 7592690  1
1995 Jhun BH, Haruta T, Meinkoth JL, Leitner JW, Draznin B, Saltiel AR, Pang L, Sasaoka T, Olefsky JM. Signal transduction pathways leading to insulin-induced early gene induction Biochemistry. 34: 7996-8004. PMID 7540866  1
1995 Mastick CC, Brady MJ, Saltiel AR. Insulin stimulates the tyrosine phosphorylation of caveolin Journal of Cell Biology. 129: 1523-1531. PMID 7540611 DOI: 10.1083/jcb.129.6.1523  1
1995 Milarski KL, Lazar DF, Wiese RJ, Saltiel AR. Detection of a 60 kDa tyrosine-phosphorylated protein in insulin-stimulated hepatoma cells that associates with the SH2 domain of phosphatidylinositol 3-kinase Biochemical Journal. 308: 579-583. PMID 7539611  1
1995 Yamauchi K, Milarski KL, Saltiel AR, Pessin JE. Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling Proceedings of the National Academy of Sciences of the United States of America. 92: 664-668. PMID 7531337 DOI: 10.1073/pnas.92.3.664  1
1995 Alessi DR, Cuenda A, Cohen P, Dudley DT, Saltiel AR. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo Journal of Biological Chemistry. 270: 27489-27494. PMID 7499206 DOI: 10.1074/jbc.270.46.27489  1
1995 Whitcomb RW, Saltiel AR. Section review: Oncologic, endocrine & metabolic: Thiazolidinediones Expert Opinion On Investigational Drugs. 4: 1299-1309. DOI: 10.1517/13543784.4.12.1299  1
1994 Rose DW, Saltiel AR, Majumdar M, Decker SJ, Olefsky JM. Insulin receptor substrate 1 is required for insulin-mediated mitogenic signal transduction Proceedings of the National Academy of Sciences of the United States of America. 91: 797-801. PMID 8290602  1
1994 Ohmichi M, Matuoka K, Takenawa T, Saltiel AR. Growth factors differentially stimulate the phosphorylation of Shc proteins and their association with Grb2 in PC-12 pheochromocytoma cells Journal of Biological Chemistry. 269: 1143-1148. PMID 8288573  1
1994 Zheng CF, Ohmichi M, Saltiel AR, Guan KL. Growth factor induced MEK activation is primarily mediated by an activator different from c-raf Biochemistry. 33: 5595-5599. PMID 8180183  1
1994 Zhu G, Decker SJ, Maclean D, McNamara DJ, Singh J, Sawyer TK, Saltiel AR. Sequence specificity in the recognition of the epidermal growth factor receptor by the abl Src homology 2 domain Oncogene. 9: 1379-1385. PMID 8152798  1
1994 Pang L, Milarski KL, Ohmichi M, Takata Y, Olefsky JM, Saltiel AR. Mutation of the two carboxyl-terminal tyrosines in the insulin receptor results in enhanced activation of mitogen-activated protein kinase Journal of Biological Chemistry. 269: 10604-10608. PMID 8144649  1
1994 Ribon V, Leff T, Saltiel AR. c-Myc does not require Max for transcriptional activity in PC-12 cells Molecular and Cellular Neurosciences. 5: 277-282. PMID 8087425 DOI: 10.1006/mcne.1994.1032  1
1994 Saltiel AR, Decker SJ. Cellular mechanisms of signal transduction for neurotrophins Bioessays. 16: 405-411. PMID 8080430  1
1994 Milarski KL, Saltiel AR. Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin Journal of Biological Chemistry. 269: 21239-21243. PMID 8063746  1
1994 Gergel JR, McNamara DJ, Dobrusin EM, Zhu G, Saltiel AR, Todd Miller W. Identification of amino acids in the N-terminal SH2 domain of phospholipase Cγ1 important in the interaction with epidermal growth factor receptor Biochemistry. 33: 14671-14678. PMID 7993895  1
1994 Pandey A, Lazar DF, Saltiel AR, Dixit VM. Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity. The Journal of Biological Chemistry. 269: 30154-7. PMID 7982920  1
1994 Misek DE, Saltiel AR. An inositol phosphate glycan derived from a Trypanosoma brucei glycosyl phosphatidylinositol promotes protein dephosphorylation in rat epididymal adipocytes Endocrinology. 135: 1869-1876. PMID 7956908 DOI: 10.1210/en.135.5.1869  1
1994 Jhun BH, Rose DW, Seely BL, Rameh L, Cantley L, Saltiel AR, Olefsky JM. Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression Molecular and Cellular Biology. 14: 7466-7475. PMID 7935461  1
1994 Saltiel AR. The paradoxical regulation of protein phosphorylation in insulin action Faseb Journal. 8: 1034-1040. PMID 7926368  1
1994 Staubs PA, Reichart DR, Saltiel AR, Milarski KL, Maegawa H, Berhanu P, Olefsky JM, Seely BL. Localization of the insulin receptor binding sites for the SH2 domain proteins p85, Syp, and GAP Journal of Biological Chemistry. 269: 27186-27192. PMID 7525547  1
1994 Lazar DF, Knez JJ, Medof ME, Cuatrecasas P, Saltiel AR. Stimulation of glycogen synthesis by insulin in human erythroleukemia cells requires the synthesis of glycosyl-phosphatidylinositol. Proceedings of the National Academy of Sciences of the United States of America. 91: 9665-9. PMID 7524086 DOI: 10.1073/pnas.91.21.9665  1
1994 Mastick CC, Kato H, Roberts CT, LeRoith D, Saltiel AR. Insulin and insulin-like growth factor-I receptors similarly stimulate deoxyribonucleic acid synthesis despite differences in cellular protein tyrosine phosphorylation Endocrinology. 135: 214-222. PMID 7516864 DOI: 10.1210/en.135.1.214  1
1994 Sasaoka T, Rose DW, Jhun BH, Saltiel AR, Draznin B, Olefsky JM. Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor Journal of Biological Chemistry. 269: 13689-13694. PMID 7513704  1
1994 Ohmichi M, Sawada T, Kanda Y, Koike K, Hirota K, Miyake A, Saltiel AR. Thyrotropin-releasing hormone stimulates MAP kinase activity in GH3 cells by divergent pathways: Evidence of a role for early tyrosine phosphorylation Journal of Biological Chemistry. 269: 3783-3788. PMID 7508919  1
1988 Saltiel AR, Osterman DG, Darnell JC, Sorbara-Cazan LR, Chan BL, Low MG, Cuatrecasas P. The function of glycosyl phosphoinositides in hormone action. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 320: 345-58. PMID 2906143  1
1988 Saltiel AR, Cuatrecasas P. In search of a second messenger for insulin. The American Journal of Physiology. 255: C1-11. PMID 2839033  1
1987 Saltiel AR, Fox JA, Sherline P, Sahyoun N, Cuatrecasas P. Purification of phosphatidylinositol kinase from bovine brain myelin. The Biochemical Journal. 241: 759-63. PMID 3036072  1
1986 Saltiel AR, Fox JA, Sherline P, Cuatrecasas P. Insulin-stimulated hydrolysis of a novel glycolipid generates modulators of cAMP phosphodiesterase. Science (New York, N.Y.). 233: 967-72. PMID 3016898  1
1986 Saltiel AR, Cuatrecasas P. Insulin stimulates the generation from hepatic plasma membranes of modulators derived from an inositol glycolipid. Proceedings of the National Academy of Sciences of the United States of America. 83: 5793-7. PMID 3016721  1
1983 Jacobs S, Sahyoun NE, Saltiel AR, Cuatrecasas P. Phorbol esters stimulate the phosphorylation of receptors for insulin and somatomedin C. Proceedings of the National Academy of Sciences of the United States of America. 80: 6211-3. PMID 6312447  1
1983 Saltiel AR, Doble A, Jacobs S, Cuatrecasas P. Putative mediators of insulin action regulate hepatic acetyl CoA carboxylase activity. Biochemical and Biophysical Research Communications. 110: 789-95. PMID 6132601 DOI: 10.1016/0006-291X(83)91031-8  1
1982 Saltiel AR, Siegel MI, Jacobs S, Cuatrecasas P. Putative mediators of insulin action: regulation of pyruvate dehydrogenase and adenylate cyclase activities. Proceedings of the National Academy of Sciences of the United States of America. 79: 3513-7. PMID 7048309  1
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