Daniel N. Bolon, Ph.D. - Publications

Biochemistry and Molecular Pharmacology University of Massachusetts Medical School, Worcester, MA, United States 
molecular evolution

37 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Bank C, Renzette N, Liu P, Matuszewski S, Shim H, Foll M, Bolon DN, Zeldovich KB, Kowalik TF, Finberg RW, Wang JP, Jensen JD. An experimental evaluation of drug-induced mutational meltdown as an antiviral treatment strategy. Evolution; International Journal of Organic Evolution. PMID 27566611 DOI: 10.1111/Evo.13041  0.72
2016 Bolon DN, Baker D, Tawfik DS. Editorial. Protein Science : a Publication of the Protein Society. PMID 27214768 DOI: 10.1002/Pro.2949  0.72
2016 Mavor D, Barlow K, Thompson S, Barad BA, Bonny AR, Cario CL, Gaskins G, Liu Z, Deming L, Axen SD, Caceres E, Chen W, Cuesta A, Gate R, Green EM, ... ... Bolon DN, et al. Determination of ubiquitin fitness landscapes under different chemical stresses in a classroom setting. Elife. 5. PMID 27111525 DOI: 10.7554/Elife.15802  0.72
2016 Mishra P, Flynn JM, Starr TN, Bolon DN. Systematic Mutant Analyses Elucidate General and Client-Specific Aspects of Hsp90 Function. Cell Reports. PMID 27068472 DOI: 10.1016/j.celrep.2016.03.046  0.72
2016 Boucher JI, Bolon DN, Tawfik DS. Quantifying and understanding the fitness effects of protein mutations: Laboratory versus nature. Protein Science : a Publication of the Protein Society. PMID 27010590 DOI: 10.1002/Pro.2928  0.72
2015 Jiang L, Liu P, Bank C, Renzette N, Prachanronarong K, Yilmaz LS, Caffrey DR, Zeldovich KB, Schiffer CA, Kowalik TF, Jensen JD, Finberg RW, Wang JP, Bolon DN. A balance between inhibitor binding and substrate processing confers influenza drug resistance. Journal of Molecular Biology. PMID 26656922 DOI: 10.1016/J.Jmb.2015.11.027  0.72
2015 Zeldovich KB, Liu P, Renzette N, Foll M, Pham ST, Venev SV, Gallagher GR, Bolon DN, Kurt-Jones EA, Jensen JD, Caffrey DR, Schiffer CA, Kowalik TF, Wang JP, Finberg RW. Positive Selection Drives Preferred Segment Combinations during Influenza Virus Reassortment. Molecular Biology and Evolution. 32: 1519-32. PMID 25713211 DOI: 10.1093/Molbev/Msv044  0.72
2015 Bank C, Hietpas RT, Jensen JD, Bolon DN. A systematic survey of an intragenic epistatic landscape. Molecular Biology and Evolution. 32: 229-38. PMID 25371431 DOI: 10.1093/Molbev/Msu301  0.72
2015 Flynn JM, Mishra P, Bolon DNA. Mechanistic Asymmetry in Hsp90 Dimers Journal of Molecular Biology. DOI: 10.1016/j.jmb.2015.03.017  0.72
2014 Boucher JI, Cote P, Flynn J, Jiang L, Laban A, Mishra P, Roscoe BP, Bolon DN. Viewing protein fitness landscapes through a next-gen lens. Genetics. 198: 461-71. PMID 25316787 DOI: 10.1534/Genetics.114.168351  0.72
2014 Foll M, Poh YP, Renzette N, Ferrer-Admetlla A, Bank C, Shim H, Malaspinas AS, Ewing G, Liu P, Wegmann D, Caffrey DR, Zeldovich KB, Bolon DN, Wang JP, Kowalik TF, et al. Influenza virus drug resistance: a time-sampled population genetics perspective. Plos Genetics. 10: e1004185. PMID 24586206 DOI: 10.1371/Journal.Pgen.1004185  0.72
2014 Bank C, Hietpas RT, Wong A, Bolon DN, Jensen JD. A Bayesian MCMC approach to assess the complete distribution of fitness effects of new mutations: Uncovering the potential for adaptive walks in challenging environments Genetics. 196: 841-852. PMID 24398421 DOI: 10.1534/Genetics.113.156190  0.72
2014 Lee SY, Pullen L, Virgil DJ, Castañeda CA, Abeykoon D, Bolon DNA, Fushman D. Alanine scan of core positions in ubiquitin reveals links between dynamics, stability, and function Journal of Molecular Biology. 426: 1377-1389. PMID 24361330 DOI: 10.1016/J.Jmb.2013.10.042  0.72
2014 Renzette N, Caffrey DR, Zeldovich KB, Liu P, Gallagher GR, Aiello D, Porter AJ, Kurt-Jones EA, Bolon DN, Poh YP, Jensen JD, Schiffer CA, Kowalik TF, Finberg RW, Wang JP. Evolution of the influenza A virus genome during development of oseltamivir resistance in vitro. Journal of Virology. 88: 272-81. PMID 24155392 DOI: 10.1128/Jvi.01067-13  0.72
2014 Wagenaar TR, Ma L, Roscoe B, Park SM, Bolon DN, Green MR. Resistance to vemurafenib resulting from a novel mutation in the BRAFV600E kinase domain. Pigment Cell & Melanoma Research. 27: 124-33. PMID 24112705 DOI: 10.1111/Pcmr.12171  0.72
2013 Hietpas RT, Bank C, Jensen JD, Bolon DNA. Shifting fitness landscapes in response to altered environments Evolution. 67: 3512-3522. PMID 24299404 DOI: 10.1111/Evo.12207  0.72
2013 Beebe K, Mollapour M, Scroggins B, Prodromou C, Xu W, Tokita M, Taldone T, Pullen L, Zierer BK, Lee MJ, Trepel J, Buchner J, Bolon D, Chiosis G, Neckers L. Posttranslational modification and conformational state of heat shock protein 90 differentially affect binding of chemically diverse small molecule inhibitors. Oncotarget. 4: 1065-74. PMID 23867252 DOI: 10.18632/Oncotarget.1099  0.72
2013 Roscoe BP, Thayer KM, Zeldovich KB, Fushman D, Bolon DNA. Analyses of the effects of all ubiquitin point mutants on yeast growth rate Journal of Molecular Biology. 425: 1363-1377. PMID 23376099 DOI: 10.1016/J.Jmb.2013.01.032  0.72
2012 Mittal S, Cai Y, Nalam MN, Bolon DN, Schiffer CA. Hydrophobic core flexibility modulates enzyme activity in HIV-1 protease. Journal of the American Chemical Society. 134: 4163-8. PMID 22295904 DOI: 10.1021/Ja2095766  0.72
2011 Wayne N, Mishra P, Bolon DN. Hsp90 and client protein maturation Methods in Molecular Biology. 787: 33-44. PMID 21898225 DOI: 10.1007/978-1-61779-295-3_3  0.72
2011 Pullen L, Bolon DN. Enforced N-domain proximity stimulates Hsp90 ATPase activity and is compatible with function in vivo Journal of Biological Chemistry. 286: 11091-11098. PMID 21278257 DOI: 10.1074/Jbc.M111.223131  0.72
2010 Wayne N, Bolon DN. Charge-Rich Regions Modulate the Anti-Aggregation Activity of Hsp90 Journal of Molecular Biology. 401: 931-939. PMID 20615417 DOI: 10.1016/J.Jmb.2010.06.066  0.72
2010 Wayne N, Lai YS, Pullen L, Bolon DN. Modular control of cross-oligomerization: Analysis of superstabilized Hsp90 homodimers in vivo Journal of Biological Chemistry. 285: 234-241. PMID 19906642 DOI: 10.1074/Jbc.M109.060129  0.72
2009 Munson M, Bolon DN. Watching proteins in motion. Genome Biology. 10: 316. PMID 19863776 DOI: 10.1186/Gb-2009-10-10-316  0.72
2008 Haririnia A, Verma R, Purohit N, Twarog MZ, Deshaies RJ, Bolon D, Fushman D. Mutations in the hydrophobic core of ubiquitin differentially affect its recognition by receptor proteins. Journal of Molecular Biology. 375: 979-96. PMID 18054791 DOI: 10.1016/J.Jmb.2007.11.016  0.72
2007 Wayne N, Bolon DN. Dimerization of Hsp90 is required for in vivo function: Design and analysis of monomers and dimers Journal of Biological Chemistry. 282: 35386-35395. PMID 17908693 DOI: 10.1074/Jbc.M703844200  0.72
2007 McGinness KE, Bolon DN, Kaganovich M, Baker TA, Sauer RT. Altered tethering of the SspB adaptor to the ClpXP protease causes changes in substrate delivery. The Journal of Biological Chemistry. 282: 11465-73. PMID 17317664 DOI: 10.1074/Jbc.M610671200  0.72
2005 Bolon DN, Grant RA, Baker TA, Sauer RT. Specificity versus stability in computational protein design. Proceedings of the National Academy of Sciences of the United States of America. 102: 12724-9. PMID 16129838 DOI: 10.1073/Pnas.0506124102  0.72
2005 Hersch GL, Burton RE, Bolon DN, Baker TA, Sauer RT. Asymmetric interactions of ATP with the AAA+ ClpX6 unfoldase: allosteric control of a protein machine. Cell. 121: 1017-27. PMID 15989952 DOI: 10.1016/J.Cell.2005.05.024  0.72
2004 Bolon DN, Grant RA, Baker TA, Sauer RT. Nucleotide-dependent substrate handoff from the SspB adaptor to the AAA+ ClpXP protease. Molecular Cell. 16: 343-50. PMID 15525508 DOI: 10.1016/J.Molcel.2004.10.001  0.72
2004 Sauer RT, Bolon DN, Burton BM, Burton RE, Flynn JM, Grant RA, Hersch GL, Joshi SA, Kenniston JA, Levchenko I, Neher SB, Oakes ES, Siddiqui SM, Wah DA, Baker TA. Sculpting the proteome with AAA(+) proteases and disassembly machines. Cell. 119: 9-18. PMID 15454077 DOI: 10.1016/J.Cell.2004.09.020  0.72
2004 Bolon DN, Wah DA, Hersch GL, Baker TA, Sauer RT. Bivalent tethering of SspB to ClpXP is required for efficient substrate delivery: a protein-design study. Molecular Cell. 13: 443-9. PMID 14967151 DOI: 10.1016/S1097-2765(04)00027-9  0.72
2003 Wah DA, Levchenko I, Rieckhof GE, Bolon DN, Baker TA, Sauer RT. Flexible linkers leash the substrate binding domain of SspB to a peptide module that stabilizes delivery complexes with the AAA+ ClpXP protease. Molecular Cell. 12: 355-63. PMID 14536075 DOI: 10.1016/S1097-2765(03)00272-7  0.72
2003 Bolon DN, Marcus JS, Ross SA, Mayo SL. Prudent modeling of core polar residues in computational protein design. Journal of Molecular Biology. 329: 611-22. PMID 12767838 DOI: 10.1016/S0022-2836(03)00423-6  0.72
2002 Bolon DN, Voigt CA, Mayo SL. De novo design of biocatalysts. Current Opinion in Chemical Biology. 6: 125-9. PMID 12038994 DOI: 10.1016/S1367-5931(02)00303-4  0.72
2001 Bolon DN, Mayo SL. Enzyme-like proteins by computational design. Proceedings of the National Academy of Sciences of the United States of America. 98: 14274-9. PMID 11724958 DOI: 10.1073/Pnas.251555398  0.72
2001 Bolon DN, Mayo SL. Polar residues in the protein core of Escherichia coli thioredoxin are important for fold specificity. Biochemistry. 40: 10047-53. PMID 11513583 DOI: 10.1021/Bi010427Y  0.72
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