Joseph A. Beavo - Publications

Affiliations: 
Pharmacology University of Washington, Seattle, Seattle, WA 
Area:
control of signal transduction by cyclic nucleotide second messengers in the cell
Website:
http://depts.washington.edu/pde/beavolab/personnel.html#Joe

225 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Shimizu-Albergine M, Van Yserloo B, Golkowski MG, Ong SE, Beavo JA, Bornfeldt KE. SCAP/SREBP pathway is required for the full steroidogenic response to cyclic AMP. Proceedings of the National Academy of Sciences of the United States of America. PMID 27601673 DOI: 10.1073/pnas.1611424113  0.52
2015 Golkowski M, Shimizu-Albergine M, Suh HW, Beavo JA, Ong SE. Studying mechanisms of cAMP and cyclic nucleotide phosphodiesterase signaling in Leydig cell function with phosphoproteomics. Cellular Signalling. PMID 26643407 DOI: 10.1016/j.cellsig.2015.11.014  1
2015 Müller U, Barr-Gillespie PG. New treatment options for hearing loss. Nature Reviews. Drug Discovery. 14: 346-65. PMID 25792261 DOI: 10.1038/nrd4533  1
2015 Francis SP, Krey JF, Krystofiak ES, Cui R, Nanda S, Xu W, Kachar B, Barr-Gillespie PG, Shin JB. A short splice form of Xin-actin binding repeat containing 2 (XIRP2) lacking the Xin repeats is required for maintenance of stereocilia morphology and hearing function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 1999-2014. PMID 25653358 DOI: 10.1523/JNEUROSCI.3449-14.2015  1
2014 Patrucco E, Domes K, Sbroggió M, Blaich A, Schlossmann J, Desch M, Rybalkin SD, Beavo JA, Lukowski R, Hofmann F. Roles of cGMP-dependent protein kinase I (cGKI) and PDE5 in the regulation of Ang II-induced cardiac hypertrophy and fibrosis. Proceedings of the National Academy of Sciences of the United States of America. 111: 12925-9. PMID 25139994 DOI: 10.1073/pnas.1414364111  1
2014 Maeda R, Kindt KS, Mo W, Morgan CP, Erickson T, Zhao H, Clemens-Grisham R, Barr-Gillespie PG, Nicolson T. Tip-link protein protocadherin 15 interacts with transmembrane channel-like proteins TMC1 and TMC2. Proceedings of the National Academy of Sciences of the United States of America. 111: 12907-12. PMID 25114259 DOI: 10.1073/pnas.1402152111  1
2014 Lukowski R, Krieg T, Rybalkin SD, Beavo J, Hofmann F. Turning on cGMP-dependent pathways to treat cardiac dysfunctions: boom, bust, and beyond. Trends in Pharmacological Sciences. 35: 404-13. PMID 24948380 DOI: 10.1016/j.tips.2014.05.003  1
2014 Powers RJ, Kulason S, Atilgan E, Brownell WE, Sun SX, Barr-Gillespie PG, Spector AA. The local forces acting on the mechanotransduction channel in hair cell stereocilia. Biophysical Journal. 106: 2519-28. PMID 24896132 DOI: 10.1016/j.bpj.2014.03.034  1
2014 Avenarius MR, Saylor KW, Lundeberg MR, Wilmarth PA, Shin JB, Spinelli KJ, Pagana JM, Andrade L, Kachar B, Choi D, David LL, Barr-Gillespie PG. Correlation of actin crosslinker and capper expression levels with stereocilia growth phases. Molecular & Cellular Proteomics : McP. 13: 606-20. PMID 24319057 DOI: 10.1074/mcp.M113.033704  1
2014 Krey JF, Wilmarth PA, Shin JB, Klimek J, Sherman NE, Jeffery ED, Choi D, David LL, Barr-Gillespie PG. Accurate label-free protein quantitation with high- and low-resolution mass spectrometers. Journal of Proteome Research. 13: 1034-44. PMID 24295401 DOI: 10.1021/pr401017h  1
2013 Barr-Gillespie PG, Nicolson T. Who needs tip links? Backwards transduction by hair cells. The Journal of General Physiology. 142: 481-6. PMID 24127528 DOI: 10.1085/jgp.201311111  1
2013 Morgan CP, Barr-Gillespie PG. Mechanotransduction: the elusive hair cell transduction channel revealed? Current Biology : Cb. 23: R887-90. PMID 24112987 DOI: 10.1016/j.cub.2013.08.031  1
2013 Demirbas D, Wyman AR, Shimizu-Albergine M, Cakici O, Beavo JA, Hoffman CS. A yeast-based chemical screen identifies a PDE inhibitor that elevates steroidogenesis in mouse Leydig cells via PDE8 and PDE4 inhibition. Plos One. 8: e71279. PMID 23967182 DOI: 10.1371/journal.pone.0071279  1
2013 Indzhykulian AA, Stepanyan R, Nelina A, Spinelli KJ, Ahmed ZM, Belyantseva IA, Friedman TB, Barr-Gillespie PG, Frolenkov GI. Molecular remodeling of tip links underlies mechanosensory regeneration in auditory hair cells. Plos Biology. 11: e1001583. PMID 23776407 DOI: 10.1371/journal.pbio.1001583  1
2013 Rybalkin SD, Hinds TR, Beavo JA. Enzyme assays for cGMP hydrolyzing phosphodiesterases. Methods in Molecular Biology (Clifton, N.J.). 1020: 51-62. PMID 23709025 DOI: 10.1007/978-1-62703-459-3_3  1
2013 Brown KM, Day JP, Huston E, Zimmermann B, Hampel K, Christian F, Romano D, Terhzaz S, Lee LC, Willis MJ, Morton DB, Beavo JA, Shimizu-Albergine M, Davies SA, Kolch W, et al. Phosphodiesterase-8A binds to and regulates Raf-1 kinase. Proceedings of the National Academy of Sciences of the United States of America. 110: E1533-42. PMID 23509299 DOI: 10.1073/pnas.1303004110  1
2013 Kraynik SM, Miyaoka RS, Beavo JA. PDE3 and PDE4 isozyme-selective inhibitors are both required for synergistic activation of brown adipose tissue. Molecular Pharmacology. 83: 1155-65. PMID 23493317 DOI: 10.1124/mol.112.084145  1
2013 Shin JB, Krey JF, Hassan A, Metlagel Z, Tauscher AN, Pagana JM, Sherman NE, Jeffery ED, Spinelli KJ, Zhao H, Wilmarth PA, Choi D, David LL, Auer M, Barr-Gillespie PG. Molecular architecture of the chick vestibular hair bundle. Nature Neuroscience. 16: 365-74. PMID 23334578 DOI: 10.1038/nn.3312  1
2012 Tsai LC, Chan GC, Nangle SN, Shimizu-Albergine M, Jones GL, Storm DR, Beavo JA, Zweifel LS. Inactivation of Pde8b enhances memory, motor performance, and protects against age-induced motor coordination decay. Genes, Brain, and Behavior. 11: 837-47. PMID 22925203 DOI: 10.1111/j.1601-183X.2012.00836.x  1
2012 Tsai LC, Beavo JA. Regulation of adrenal steroidogenesis by the high-affinity phosphodiesterase 8 family. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et MéTabolisme. 44: 790-4. PMID 22903278 DOI: 10.1055/s-0032-1321861  1
2012 Percival JM, Whitehead NP, Adams ME, Adamo CM, Beavo JA, Froehner SC. Sildenafil reduces respiratory muscle weakness and fibrosis in the mdx mouse model of Duchenne muscular dystrophy. The Journal of Pathology. 228: 77-87. PMID 22653783 DOI: 10.1002/path.4054  1
2012 Shimizu-Albergine M, Tsai LC, Patrucco E, Beavo JA. cAMP-specific phosphodiesterases 8A and 8B, essential regulators of Leydig cell steroidogenesis. Molecular Pharmacology. 81: 556-66. PMID 22232524 DOI: 10.1124/mol.111.076125  1
2012 Sonnenburg WK, Wayman GA, Storm DR, Beavo JA. Cyclic Nucleotide Regulation by Calmodulin Calmodulin and Signal Transduction. 237-286. DOI: 10.1016/B978-0-08-092636-0.50009-8  1
2011 Tsai LC, Beavo JA. The roles of cyclic nucleotide phosphodiesterases (PDEs) in steroidogenesis. Current Opinion in Pharmacology. 11: 670-5. PMID 21962440 DOI: 10.1016/j.coph.2011.09.003  1
2011 Temkitthawon P, Hinds TR, Beavo JA, Viyoch J, Suwanborirux K, Pongamornkul W, Sawasdee P, Ingkaninan K. Kaempferia parviflora, a plant used in traditional medicine to enhance sexual performance contains large amounts of low affinity PDE5 inhibitors. Journal of Ethnopharmacology. 137: 1437-41. PMID 21884777 DOI: 10.1016/j.jep.2011.08.025  1
2011 Hertz AL, Beavo JA. Cyclic nucleotides and phosphodiesterases in monocytic differentiation. Handbook of Experimental Pharmacology. 365-90. PMID 21695649 DOI: 10.1007/978-3-642-17969-3_16  1
2011 Percival JM, Adamo CM, Beavo JA, Froehner SC. Evaluation of the therapeutic utility of phosphodiesterase 5A inhibition in the mdx mouse model of duchenne muscular dystrophy. Handbook of Experimental Pharmacology. 323-44. PMID 21695647 DOI: 10.1007/978-3-642-17969-3_14  1
2011 Surapisitchat J, Beavo JA. Regulation of endothelial barrier function by cyclic nucleotides: the role of phosphodiesterases. Handbook of Experimental Pharmacology. 193-210. PMID 21695641 DOI: 10.1007/978-3-642-17969-3_8  1
2011 Tsai LC, Shimizu-Albergine M, Beavo JA. The high-affinity cAMP-specific phosphodiesterase 8B controls steroidogenesis in the mouse adrenal gland. Molecular Pharmacology. 79: 639-48. PMID 21187369 DOI: 10.1124/mol.110.069104  1
2011 Beavo JA. Phosphodiesterase 8B Xpharm: the Comprehensive Pharmacology Reference. 1-11. DOI: 10.1016/B978-008055232-3.63512-3  1
2011 Beavo JA. Phosphodiesterases 8 Xpharm: the Comprehensive Pharmacology Reference. 1-4. DOI: 10.1016/B978-008055232-3.63094-6  1
2011 Beavo JA. Phosphodiesterases 7 Xpharm: the Comprehensive Pharmacology Reference. 1-4. DOI: 10.1016/B978-008055232-3.63093-4  1
2011 Conti M, Jin SLC, Beavo JA. Phosphodiesterase 4D Xpharm: the Comprehensive Pharmacology Reference. 1-20. DOI: 10.1016/B978-008055232-3.63012-0  1
2011 Conti M, Jin SLC, Beavo JA. Phosphodiesterase 4B Xpharm: the Comprehensive Pharmacology Reference. 1-12. DOI: 10.1016/B978-008055232-3.63011-9  1
2011 Conti M, Jin SLC, Beavo JA. Phosphodiesterase 4A Xpharm: the Comprehensive Pharmacology Reference. 1-19. DOI: 10.1016/B978-008055232-3.63010-7  1
2011 Vasta V, Beavo JA. Phosphodiesterase 7B Xpharm: the Comprehensive Pharmacology Reference. 1-8. DOI: 10.1016/B978-008055232-3.63009-0  1
2011 Vasta V, Beavo JA. Phosphodiesterase 7A Xpharm: the Comprehensive Pharmacology Reference. 1-8. DOI: 10.1016/B978-008055232-3.63008-9  1
2011 Beavo JA. Phosphodiesterase 3B Xpharm: the Comprehensive Pharmacology Reference. 1-8. DOI: 10.1016/B978-008055232-3.63007-7  1
2011 Beavo JA. Phosphodiesterase 3A Xpharm: the Comprehensive Pharmacology Reference. 1-8. DOI: 10.1016/B978-008055232-3.63006-5  1
2011 Beavo JA. Phosphodiesterases 3 Xpharm: the Comprehensive Pharmacology Reference. 1-6. DOI: 10.1016/B978-008055232-3.63005-3  1
2011 Yan C, Beavo JA. Phosphodiesterase 1C Xpharm: the Comprehensive Pharmacology Reference. 1-14. DOI: 10.1016/B978-008055232-3.63004-1  1
2011 Bender A, Yan C, Beavo JA. Phosphodiesterase 1B Xpharm: the Comprehensive Pharmacology Reference. 1-7. DOI: 10.1016/B978-008055232-3.63003-X  1
2011 Yan C, Beavo JA. Phosphodiesterase 1A Xpharm: the Comprehensive Pharmacology Reference. 1-18. DOI: 10.1016/B978-008055232-3.63002-8  1
2011 Yan C, Beavo JA. Phosphodiesterases 1 Xpharm: the Comprehensive Pharmacology Reference. 1-5. DOI: 10.1016/B978-008055232-3.63001-6  1
2011 Surapisitchat J, Beavo JA. Phosphodiesterase 11 Xpharm: the Comprehensive Pharmacology Reference. 1-10. DOI: 10.1016/B978-008055232-3.62931-9  1
2011 Narula A, Laxman S, Beavo JA. Phosphodiesterase 10 Xpharm: the Comprehensive Pharmacology Reference. 1-11. DOI: 10.1016/B978-008055232-3.60551-3  1
2011 Glick J, Beavo JA. Phosphodiesterase 9 Xpharm: the Comprehensive Pharmacology Reference. 1-6. DOI: 10.1016/B978-008055232-3.60550-1  1
2011 Huang D, Beavo JA. Phosphodiesterase 6 Xpharm: the Comprehensive Pharmacology Reference. 1-16. DOI: 10.1016/B978-008055232-3.60548-3  1
2011 Rybalkin SD, Beavo JA. Phosphodiesterase 5 Xpharm: the Comprehensive Pharmacology Reference. 1-16. DOI: 10.1016/B978-008055232-3.60547-1  1
2011 Martinez SE, Beavo JA. Phosphodiesterase 2 Xpharm: the Comprehensive Pharmacology Reference. 1-11. DOI: 10.1016/B978-008055232-3.60546-X  1
2010 Adamo CM, Dai DF, Percival JM, Minami E, Willis MS, Patrucco E, Froehner SC, Beavo JA. Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy. Proceedings of the National Academy of Sciences of the United States of America. 107: 19079-83. PMID 20956307 DOI: 10.1073/pnas.1013077107  1
2010 Patrucco E, Albergine MS, Santana LF, Beavo JA. Phosphodiesterase 8A (PDE8A) regulates excitation-contraction coupling in ventricular myocytes. Journal of Molecular and Cellular Cardiology. 49: 330-3. PMID 20353794 DOI: 10.1016/j.yjmcc.2010.03.016  1
2010 Lukowski R, Rybalkin SD, Loga F, Leiss V, Beavo JA, Hofmann F. Cardiac hypertrophy is not amplified by deletion of cGMP-dependent protein kinase I in cardiomyocytes. Proceedings of the National Academy of Sciences of the United States of America. 107: 5646-51. PMID 20212138 DOI: 10.1073/pnas.1001360107  1
2010 Lukowski R, Rybalkin SD, Beavo JA, Hofmann F. Reply to Kass and Takimoto: Cardiac hypertrophy without cGKI and PDE5 in cardiac myocytes Proceedings of the National Academy of Sciences of the United States of America. 107: E99. DOI: 10.1073/pnas.1005248107  1
2010 Martinez SE, Heikaus CC, Beavo JA. Cyclic nucleotide-binding gaf domains in phosphodiesterases and adenylyl cyclases Handbook of Cell Signaling, 2/E. 2: 1531-1536. DOI: 10.1016/B978-0-12-374145-5.00187-X  1
2010 Surapisitchat J, Beavo JA. Phosphodiesterase Families Handbook of Cell Signaling, 2/E. 2: 1409-1414. DOI: 10.1016/B978-0-12-374145-5.00173-X  1
2009 Hertz AL, Bender AT, Smith KC, Gilchrist M, Amieux PS, Aderem A, Beavo JA. Elevated cyclic AMP and PDE4 inhibition induce chemokine expression in human monocyte-derived macrophages. Proceedings of the National Academy of Sciences of the United States of America. 106: 21978-83. PMID 19959669 DOI: 10.1073/pnas.0911684106  1
2009 Miller CL, Oikawa M, Cai Y, Wojtovich AP, Nagel DJ, Xu X, Xu H, Florio V, Rybalkin SD, Beavo JA, Chen YF, Li JD, Blaxall BC, Abe J, Yan C. Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy. Circulation Research. 105: 956-64. PMID 19797176 DOI: 10.1161/CIRCRESAHA.109.198515  1
2008 Martinez SE, Heikaus CC, Klevit RE, Beavo JA. The structure of the GAF A domain from phosphodiesterase 6C reveals determinants of cGMP binding, a conserved binding surface, and a large cGMP-dependent conformational change. The Journal of Biological Chemistry. 283: 25913-9. PMID 18614542 DOI: 10.1074/jbc.M802891200  1
2008 Heikaus CC, Stout JR, Sekharan MR, Eakin CM, Rajagopal P, Brzovic PS, Beavo JA, Klevit RE. Solution structure of the cGMP binding GAF domain from phosphodiesterase 5: insights into nucleotide specificity, dimerization, and cGMP-dependent conformational change. The Journal of Biological Chemistry. 283: 22749-59. PMID 18534985 DOI: 10.1074/jbc.M801577200  1
2008 Poppe H, Rybalkin SD, Rehmann H, Hinds TR, Tang XB, Christensen AE, Schwede F, Genieser HG, Bos JL, Doskeland SO, Beavo JA, Butt E. Cyclic nucleotide analogs as probes of signaling pathways. Nature Methods. 5: 277-8. PMID 18376388 DOI: 10.1038/nmeth0408-277  1
2007 Kass DA, Champion HC, Beavo JA. Phosphodiesterase type 5: expanding roles in cardiovascular regulation. Circulation Research. 101: 1084-95. PMID 18040025 DOI: 10.1161/CIRCRESAHA.107.162511  1
2007 Laxman S, Beavo JA. Cyclic nucleotide signaling mechanisms in trypanosomes: possible targets for therapeutic agents. Molecular Interventions. 7: 203-15. PMID 17827441 DOI: 10.1124/mi.7.4.7  1
2007 Surapisitchat J, Jeon KI, Yan C, Beavo JA. Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3. Circulation Research. 101: 811-8. PMID 17704206 DOI: 10.1161/CIRCRESAHA.107.154229  1
2007 Conti M, Beavo J. Biochemistry and physiology of cyclic nucleotide phosphodiesterases: Essential components in cyclic nucleotide signaling Annual Review of Biochemistry. 76: 481-511. PMID 17376027 DOI: 10.1146/annurev.biochem.76.060305.150444  1
2007 Askari B, Kanter JE, Sherrid AM, Golej DL, Bender AT, Liu J, Hsueh WA, Beavo JA, Coleman RA, Bornfeldt KE. Rosiglitazone inhibits acyl-CoA synthetase activity and fatty acid partitioning to diacylglycerol and triacylglycerol via a peroxisome proliferator-activated receptor-gamma-independent mechanism in human arterial smooth muscle cells and macrophages. Diabetes. 56: 1143-52. PMID 17259370 DOI: 10.2337/db06-0267  1
2007 Gavin MA, Rasmussen JP, Fontenot JD, Vasta V, Manganiello VC, Beavo JA, Rudensky AY. Foxp3-dependent programme of regulatory T-cell differentiation. Nature. 445: 771-5. PMID 17220874 DOI: 10.1038/nature05543  1
2006 Vasta V, Shimizu-Albergine M, Beavo JA. Modulation of Leydig cell function by cyclic nucleotide phosphodiesterase 8A. Proceedings of the National Academy of Sciences of the United States of America. 103: 19925-30. PMID 17172443 DOI: 10.1073/pnas.0609483103  1
2006 Laxman S, Riechers A, Sadilek M, Schwede F, Beavo JA. Hydrolysis products of cAMP analogs cause transformation of Trypanosoma brucei from slender to stumpy-like forms. Proceedings of the National Academy of Sciences of the United States of America. 103: 19194-9. PMID 17142316 DOI: 10.1073/pnas.0608971103  1
2006 Bender AT, Beavo JA. Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use. Pharmacological Reviews. 58: 488-520. PMID 16968949 DOI: 10.1124/pr.58.3.5  1
2006 Díaz-Benjumea R, Laxman S, Hinds TR, Beavo JA, Rascón A. Characterization of a novel cAMP-binding, cAMP-specific cyclic nucleotide phosphodiesterase (TcrPDEB1) from Trypanosoma cruzi. The Biochemical Journal. 399: 305-14. PMID 16776650 DOI: 10.1042/BJ20060757  1
2006 Bender AT, Beavo JA. PDE1B2 regulates cGMP and a subset of the phenotypic characteristics acquired upon macrophage differentiation from a monocyte. Proceedings of the National Academy of Sciences of the United States of America. 103: 460-5. PMID 16407168 DOI: 10.1073/pnas.0509972102  1
2006 Kunz S, Beavo JA, D'Angelo MA, Flawia MM, Francis SH, Johner A, Laxman S, Oberholzer M, Rascon A, Shakur Y, Wentzinger L, Zoraghi R, Seebeck T. Cyclic nucleotide specific phosphodiesterases of the kinetoplastida: a unified nomenclature. Molecular and Biochemical Parasitology. 145: 133-5. PMID 16280178 DOI: 10.1016/j.molbiopara.2005.09.018  1
2005 Vasta V, Sonnenburg WK, Yan C, Soderling SH, Shimizu-Albergine M, Beavo JA. Identification of a new variant of PDE1A calmodulin-stimulated cyclic nucleotide phosphodiesterase expressed in mouse sperm. Biology of Reproduction. 73: 598-609. PMID 15901640 DOI: 10.1095/biolreprod.104.039180  1
2005 Martinez SE, Bruder S, Schultz A, Zheng N, Schultz JE, Beavo JA, Linder JU. Crystal structure of the tandem GAF domains from a cyanobacterial adenylyl cyclase: modes of ligand binding and dimerization. Proceedings of the National Academy of Sciences of the United States of America. 102: 3082-7. PMID 15708973 DOI: 10.1073/pnas.0409913102  1
2005 Bruder S, Linder JU, Martinez SE, Zheng N, Beavo JA, Schultz JE. The cyanobacterial tandem GAF domains from the cyaB2 adenylyl cyclase signal via both cAMP-binding sites. Proceedings of the National Academy of Sciences of the United States of America. 102: 3088-92. PMID 15708972 DOI: 10.1073/pnas.0409917102  1
2005 Bender AT, Ostenson CL, Wang EH, Beavo JA. Selective up-regulation of PDE1B2 upon monocyte-to-macrophage differentiation. Proceedings of the National Academy of Sciences of the United States of America. 102: 497-502. PMID 15625104 DOI: 10.1073/pnas.0408535102  1
2005 Laxman S, Rascón A, Beavo JA. Trypanosome cyclic nucleotide phosphodiesterase 2B binds cAMP through its GAF-A domain. The Journal of Biological Chemistry. 280: 3771-9. PMID 15563461 DOI: 10.1074/jbc.M408111200  1
2004 Asirvatham AL, Galligan SG, Schillace RV, Davey MP, Vasta V, Beavo JA, Carr DW. A-kinase anchoring proteins interact with phosphodiesterases in T lymphocyte cell lines. Journal of Immunology (Baltimore, Md. : 1950). 173: 4806-14. PMID 15470020  1
2004 Huang D, Hinds TR, Martinez SE, Doneanu C, Beavo JA. Molecular determinants of cGMP binding to chicken cone photoreceptor phosphodiesterase. The Journal of Biological Chemistry. 279: 48143-51. PMID 15331594 DOI: 10.1074/jbc.M404338200  1
2004 Bender AT, Beavo JA. Specific localized expression of cGMP PDEs in Purkinje neurons and macrophages. Neurochemistry International. 45: 853-7. PMID 15312979 DOI: 10.1016/j.neuint.2004.03.015  1
2004 Wu AY, Tang XB, Martinez SE, Ikeda K, Beavo JA. Molecular determinants for cyclic nucleotide binding to the regulatory domains of phosphodiesterase 2A. The Journal of Biological Chemistry. 279: 37928-38. PMID 15210692 DOI: 10.1074/jbc.M404287200  1
2004 Bender AT, Ostenson CL, Giordano D, Beavo JA. Differentiation of human monocytes in vitro with granulocyte-macrophage colony-stimulating factor and macrophage colony-stimulating factor produces distinct changes in cGMP phosphodiesterase expression. Cellular Signalling. 16: 365-74. PMID 14687666 DOI: 10.1016/j.cellsig.2003.08.009  1
2003 Giordano D, Magaletti DM, Clark EA, Beavo JA. Cyclic nucleotides promote monocyte differentiation toward a DC-SIGN+ (CD209) intermediate cell and impair differentiation into dendritic cells. Journal of Immunology (Baltimore, Md. : 1950). 171: 6421-30. PMID 14662841  1
2003 Van Staveren WC, Steinbusch HW, Markerink-Van Ittersum M, Repaske DR, Goy MF, Kotera J, Omori K, Beavo JA, De Vente J. mRNA expression patterns of the cGMP-hydrolyzing phosphodiesterases types 2, 5, and 9 during development of the rat brain. The Journal of Comparative Neurology. 467: 566-80. PMID 14624489 DOI: 10.1002/cne.10955  1
2003 Rybalkin SD, Yan C, Bornfeldt KE, Beavo JA. Cyclic GMP phosphodiesterases and regulation of smooth muscle function. Circulation Research. 93: 280-91. PMID 12933699 DOI: 10.1161/01.RES.0000087541.15600.2B  1
2003 Shimizu-Albergine M, Rybalkin SD, Rybalkina IG, Feil R, Wolfsgruber W, Hofmann F, Beavo JA. Individual cerebellar Purkinje cells express different cGMP phosphodiesterases (PDEs): in vivo phosphorylation of cGMP-specific PDE (PDE5) as an indicator of cGMP-dependent protein kinase (PKG) activation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 6452-9. PMID 12878685  1
2003 Rybalkin SD, Rybalkina IG, Shimizu-Albergine M, Tang XB, Beavo JA. PDE5 is converted to an activated state upon cGMP binding to the GAF A domain. The Embo Journal. 22: 469-78. PMID 12554648 DOI: 10.1093/emboj/cdg051  1
2003 Muradov KG, Boyd KK, Martinez SE, Beavo JA, Artemyev NO. The GAFa domains of rod cGMP-phosphodiesterase 6 determine the selectivity of the enzyme dimerization. The Journal of Biological Chemistry. 278: 10594-601. PMID 12531898 DOI: 10.1074/jbc.M208456200  1
2003 Martinez SE, Tang XB, Turley S, Hol WGJ, Beavo JA. Cyclic Nucleotide-Biding Phosphodiesterase and Cyclase GAF Domains Handbook of Cell Signaling. 2: 525-529. DOI: 10.1016/B978-012124546-7/50568-4  1
2003 Glick JL, Beavo JA. Phosphodiesterase Families Handbook of Cell Signaling. 2: 431-435. DOI: 10.1016/B978-012124546-7/50553-2  1
2002 Martinez SE, Beavo JA, Hol WG. GAF domains: two-billion-year-old molecular switches that bind cyclic nucleotides. Molecular Interventions. 2: 317-23. PMID 14993386 DOI: 10.1124/mi.2.5.317  1
2002 van Staveren WC, Glick J, Markerink-van Ittersum M, Shimizu M, Beavo JA, Steinbusch HW, de Vente J. Cloning and localization of the cGMP-specific phosphodiesterase type 9 in the rat brain. Journal of Neurocytology. 31: 729-41. PMID 14501210 DOI: 10.1023/A:1025704031210  1
2002 Martinez SE, Wu AY, Glavas NA, Tang XB, Turley S, Hol WG, Beavo JA. The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding. Proceedings of the National Academy of Sciences of the United States of America. 99: 13260-5. PMID 12271124 DOI: 10.1073/pnas.192374899  1
2002 Beavo JA, Brunton LL. Cyclic nucleotide research -- still expanding after half a century. Nature Reviews. Molecular Cell Biology. 3: 710-8. PMID 12209131 DOI: 10.1038/nrm911  1
2002 Rascón A, Soderling SH, Schaefer JB, Beavo JA. Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei. Proceedings of the National Academy of Sciences of the United States of America. 99: 4714-9. PMID 11930017 DOI: 10.1073/pnas.002031599  1
2002 Rybalkin SD, Rybalkina I, Beavo JA, Bornfeldt KE. Cyclic nucleotide phosphodiesterase 1C promotes human arterial smooth muscle cell proliferation. Circulation Research. 90: 151-7. PMID 11834707 DOI: 10.1161/hh0202.104108  1
2002 Rybalkin SD, Rybalkina IG, Feil R, Hofmann F, Beavo JA. Regulation of cGMP-specific phosphodiesterase (PDE5) phosphorylation in smooth muscle cells. The Journal of Biological Chemistry. 277: 3310-7. PMID 11723116 DOI: 10.1074/jbc.M106562200  1
2001 Kim D, Rybalkin SD, Pi X, Wang Y, Zhang C, Munzel T, Beavo JA, Berk BC, Yan C. Upregulation of phosphodiesterase 1A1 expression is associated with the development of nitrate tolerance. Circulation. 104: 2338-43. PMID 11696475  1
2001 Glavas NA, Ostenson C, Schaefer JB, Vasta V, Beavo JA. T cell activation up-regulates cyclic nucleotide phosphodiesterases 8A1 and 7A3. Proceedings of the National Academy of Sciences of the United States of America. 98: 6319-24. PMID 11371644 DOI: 10.1073/pnas.101131098  1
2001 Yan C, Zhao AZ, Sonnenburg WK, Beavo JA. Stage and cell-specific expression of calmodulin-dependent phosphodiesterases in mouse testis. Biology of Reproduction. 64: 1746-54. PMID 11369604  1
2001 Shimizu-Albergine M, Ippolito DL, Beavo JA. Downregulation of fasting-induced cAMP response element-mediated gene induction by leptin in neuropeptide Y neurons of the arcuate nucleus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 1238-46. PMID 11160394  1
2001 Cook TA, Ghomashchi F, Gelb MH, Florio SK, Beavo JA. The delta subunit of type 6 phosphodiesterase reduces light-induced cGMP hydrolysis in rod outer segments. The Journal of Biological Chemistry. 276: 5248-55. PMID 11053432 DOI: 10.1074/jbc.M004690200  1
2000 Cook TA, Ghomashchi F, Gelb MH, Florio SK, Beavo JA. Binding of the delta subunit to rod phosphodiesterase catalytic subunits requires methylated, prenylated C-termini of the catalytic subunits. Biochemistry. 39: 13516-23. PMID 11063588 DOI: 10.1021/bi001070l  1
2000 Hetman JM, Robas N, Baxendale R, Fidock M, Phillips SC, Soderling SH, Beavo JA. Cloning and characterization of two splice variants of human phosphodiesterase 11A. Proceedings of the National Academy of Sciences of the United States of America. 97: 12891-5. PMID 11050148 DOI: 10.1073/pnas.200355397  1
2000 Sun Y, Li L, Lau F, Beavo JA, Clark EA. Infection of CD4+ memory T cells by HIV-1 requires expression of phosphodiesterase 4. Journal of Immunology (Baltimore, Md. : 1950). 165: 1755-61. PMID 10925252  1
2000 Zhao AZ, Shinohara MM, Huang D, Shimizu M, Eldar-Finkelman H, Krebs EG, Beavo JA, Bornfeldt KE. Leptin induces insulin-like signaling that antagonizes cAMP elevation by glucagon in hepatocytes. The Journal of Biological Chemistry. 275: 11348-54. PMID 10753948 DOI: 10.1074/jbc.275.15.11348  1
2000 Cook TA, Beavo JA. Purification and assay of bovine type 6 photoreceptor phosphodiesterase and its subunits. Methods in Enzymology. 315: 597-616. PMID 10736729  1
2000 Fawcett L, Baxendale R, Stacey P, McGrouther C, Harrow I, Soderling S, Hetman J, Beavo JA, Phillips SC. Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A. Proceedings of the National Academy of Sciences of the United States of America. 97: 3702-7. PMID 10725373 DOI: 10.1073/pnas.050585197  1
2000 Soderling SH, Beavo JA. Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions. Current Opinion in Cell Biology. 12: 174-9. PMID 10712916 DOI: 10.1016/S0955-0674(99)00073-3  1
2000 Hetman JM, Soderling SH, Glavas NA, Beavo JA. Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase. Proceedings of the National Academy of Sciences of the United States of America. 97: 472-6. PMID 10618442 DOI: 10.1073/pnas.97.1.472  1
1999 Mou H, Grazio HJ, Cook TA, Beavo JA, Cote RH. cGMP binding to noncatalytic sites on mammalian rod photoreceptor phosphodiesterase is regulated by binding of its gamma and delta subunits. The Journal of Biological Chemistry. 274: 18813-20. PMID 10373499 DOI: 10.1074/jbc.274.26.18813  1
1999 Soderling SH, Bayuga SJ, Beavo JA. Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A. Proceedings of the National Academy of Sciences of the United States of America. 96: 7071-6. PMID 10359840 DOI: 10.1073/pnas.96.12.7071  1
1999 Li L, Yee C, Beavo JA. CD3- and CD28-dependent induction of PDE7 required for T cell activation. Science (New York, N.Y.). 283: 848-51. PMID 9933169 DOI: 10.1126/science.283.5403.848  1
1999 Juilfs DM, Soderling S, Burns F, Beavo JA. Cyclic GMP as substrate and regulator of cyclic nucleotide phosphodiesterases (PDEs). Reviews of Physiology, Biochemistry and Pharmacology. 135: 67-104. PMID 9932481  1
1998 Wei J, Zhao AZ, Chan GC, Baker LP, Impey S, Beavo JA, Storm DR. Phosphorylation and inhibition of olfactory adenylyl cyclase by CaM kinase II in Neurons: a mechanism for attenuation of olfactory signals. Neuron. 21: 495-504. PMID 9768837 DOI: 10.1016/S0896-6273(00)80561-9  1
1998 Zhao AZ, Bornfeldt KE, Beavo JA. Leptin inhibits insulin secretion by activation of phosphodiesterase 3B. The Journal of Clinical Investigation. 102: 869-73. PMID 9727054 DOI: 10.1172/JCI3920  1
1998 Loughney K, Hill TR, Florio VA, Uher L, Rosman GJ, Wolda SL, Jones BA, Howard ML, McAllister-Lucas LM, Sonnenburg WK, Francis SH, Corbin JD, Beavo JA, Ferguson K. Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase. Gene. 216: 139-47. PMID 9714779 DOI: 10.1016/S0378-1119(98)00303-5  1
1998 Soderling SH, Bayuga SJ, Beavo JA. Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase. Proceedings of the National Academy of Sciences of the United States of America. 95: 8991-6. PMID 9671792 DOI: 10.1073/pnas.95.15.8991  1
1998 Soderling SH, Bayuga SJ, Beavo JA. Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases. The Journal of Biological Chemistry. 273: 15553-8. PMID 9624145 DOI: 10.1074/jbc.273.25.15553  1
1998 Li N, Florio SK, Pettenati MJ, Rao PN, Beavo JA, Baehr W. Characterization of human and mouse rod cGMP phosphodiesterase delta subunit (PDE6D) and chromosomal localization of the human gene. Genomics. 49: 76-82. PMID 9570951 DOI: 10.1006/geno.1998.5210  1
1998 Sonnenburg WK, Rybalkin SD, Bornfeldt KE, Kwak KS, Rybalkina IG, Beavo JA. Identification, quantitation, and cellular localization of PDE1 calmodulin-stimulated cyclic nucleotide phosphodiesterases. Methods (San Diego, Calif.). 14: 3-19. PMID 9500854 DOI: 10.1006/meth.1997.0561  1
1997 Yu J, Wolda SL, Frazier AL, Florio VA, Martins TJ, Snyder PB, Harris EA, McCaw KN, Farrell CA, Steiner B, Bentley JK, Beavo JA, Ferguson K, Gelinas R. Identification and characterisation of a human calmodulin-stimulated phosphodiesterase PDE1B1. Cellular Signalling. 9: 519-29. PMID 9419816 DOI: 10.1016/S0898-6568(97)00046-6  1
1997 Rybalkin SD, Bornfeldt KE, Sonnenburg WK, Rybalkina IG, Kwak KS, Hanson K, Krebs EG, Beavo JA. Calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1C) is induced in human arterial smooth muscle cells of the synthetic, proliferative phenotype. The Journal of Clinical Investigation. 100: 2611-21. PMID 9366577 DOI: 10.1172/JCI119805  1
1997 Zhao AZ, Yan C, Sonnenburg WK, Beavo JA. Recent advances in the study of Ca2+/CaM-activated phosphodiesterases: expression and physiological functions. Advances in Second Messenger and Phosphoprotein Research. 31: 237-51. PMID 9344255  1
1997 Rosman GJ, Martins TJ, Sonnenburg WK, Beavo JA, Ferguson K, Loughney K. Isolation and characterization of human cDNAs encoding a cGMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase. Gene. 191: 89-95. PMID 9210593 DOI: 10.1016/S0378-1119(97)00046-2  1
1997 Juilfs DM, Fülle HJ, Zhao AZ, Houslay MD, Garbers DL, Beavo JA. A subset of olfactory neurons that selectively express cGMP-stimulated phosphodiesterase (PDE2) and guanylyl cyclase-D define a unique olfactory signal transduction pathway. Proceedings of the National Academy of Sciences of the United States of America. 94: 3388-95. PMID 9096404 DOI: 10.1073/pnas.94.7.3388  1
1997 Zhao AZ, Zhao H, Teague J, Fujimoto W, Beavo JA. Attenuation of insulin secretion by insulin-like growth factor 1 is mediated through activation of phosphodiesterase 3B. Proceedings of the National Academy of Sciences of the United States of America. 94: 3223-8. PMID 9096374 DOI: 10.1073/pnas.94.7.3223  1
1996 Rybalkin SD, Beavo JA. Multiplicity within cyclic nucleotide phosphodiesterases. Biochemical Society Transactions. 24: 1005-9. PMID 8968501  1
1996 Bloom TJ, Beavo JA. Identification and tissue-specific expression of PDE7 phosphodiesterase splice variants. Proceedings of the National Academy of Sciences of the United States of America. 93: 14188-92. PMID 8943082 DOI: 10.1073/pnas.93.24.14188  1
1996 Yan C, Zhao AZ, Bentley JK, Beavo JA. The calmodulin-dependent phosphodiesterase gene PDE1C encodes several functionally different splice variants in a tissue-specific manner. The Journal of Biological Chemistry. 271: 25699-706. PMID 8810348 DOI: 10.1074/jbc.271.41.25699  1
1996 Florio SK, Prusti RK, Beavo JA. Solubilization of membrane-bound rod phosphodiesterase by the rod phosphodiesterase recombinant delta subunit. The Journal of Biological Chemistry. 271: 24036-47. PMID 8798640 DOI: 10.1074/jbc.271.39.24036  1
1996 Burns F, Zhao AZ, Beavo JA. Cyclic nucleotide phosphodiesterases: gene complexity, regulation by phosphorylation, and physiological implications. Advances in Pharmacology (San Diego, Calif.). 36: 29-48. PMID 8783553 DOI: 10.1016/S1054-3589(08)60575-X  1
1996 Loughney K, Martins TJ, Harris EA, Sadhu K, Hicks JB, Sonnenburg WK, Beavo JA, Ferguson K. Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases. The Journal of Biological Chemistry. 271: 796-806. PMID 8557689  1
1996 Kelley Bentley J, Beavo JA. Chapter 3 The role of multiple isozymes in the regulation of cyclic nucleotide synthesis and degradation Principles of Medical Biology. 4: 77-122. DOI: 10.1016/S1569-2582(96)80090-0  1
1996 Bums F, K'Hansoirt, Millert IB, Rvbaîkin S, Clarkel WR, Beavo JA. Localization of PDE5 in mouse lung and brain and cloning of two mouse PDE5 isoforms Biochemical Society Transactions. 24: 623S.  1
1996 Beavo JA. Localization, regulation, and function of cyclic nucleotide phosphodiesterases Biochemical Society Transactions. 24: 582S.  1
1996 Zhao AZ, Beavo JA. Regulation of cAMP-potentiated insulin secretion from pancreatic islet β- cells throuah phosohodi-esterase (PDE) 3B Biochemical Society Transactions. 24: 582S.  1
1996 Rybalkin SD, Sonnenburg WK, Beavo JA, Bornfeldt KE. A CaM-dependent phosphodiesterase (PDE1C) is induced in human arterial smooth muscle cells during transition from intact aorta to cell culture Biochemical Society Transactions. 24: 582S.  1
1996 Juilfs DM, Sonnenburg WK, Seraji S, Fülle HJ, Garbers DL, Houslav MD, Beavo JA. Identification of a new PDE2A isoform and expression of PDE2 in a subset of olfactory neurons & gastrointestinal cells Biochemical Society Transactions. 24: 624S.  1
1996 Van C, Zhao A, Benlley JK, Beavo JA. The calmodulin-dependent phosphodiesterase gene pde1c encodes several functionally different splice variants in a tissue specific manner Biochemical Society Transactions. 24: 623S.  1
1995 Sonnenburg WK, Seger D, Kwak KS, Huang J, Charbonneau H, Beavo JA. Identification of inhibitory and calmodulin-binding domains of the PDE1A1 and PDE1A2 calmodulin-stimulated cyclic nucleotide phosphodiesterases. The Journal of Biological Chemistry. 270: 30989-1000. PMID 8537356 DOI: 10.1074/jbc.270.52.30989  1
1995 McAllister-Lucas LM, Haik TL, Colbran JL, Sonnenburg WK, Seger D, Turko IV, Beavo JA, Francis SH, Corbin JD. An essential aspartic acid at each of two allosteric cGMP-binding sites of a cGMP-specific phosphodiesterase. The Journal of Biological Chemistry. 270: 30671-9. PMID 8530505 DOI: 10.1074/jbc.270.51.30671  1
1995 Butt E, Beltman J, Becker DE, Jensen GS, Rybalkin SD, Jastorff B, Beavo JA. Characterization of cyclic nucleotide phosphodiesterases with cyclic AMP analogs: topology of the catalytic sites and comparison with other cyclic AMP-binding proteins. Molecular Pharmacology. 47: 340-7. PMID 7870042  1
1995 Beltman J, Becker DE, Butt E, Jensen GS, Rybalkin SD, Jastorff B, Beavo JA. Characterization of cyclic nucleotide phosphodiesterases with cyclic GMP analogs: topology of the catalytic domains. Molecular Pharmacology. 47: 330-9. PMID 7870041  1
1995 Beavo JA. cGMP inhibition of heart phosphodiesterase: is it clinically relevant? The Journal of Clinical Investigation. 95: 445. PMID 7860725 DOI: 10.1172/JCI117683  1
1995 Yan C, Zhao AZ, Bentley JK, Loughney K, Ferguson K, Beavo JA. Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons. Proceedings of the National Academy of Sciences of the United States of America. 92: 9677-81. PMID 7568196 DOI: 10.1073/pnas.92.21.9677  1
1995 Beavo JA. Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. Physiological Reviews. 75: 725-48. PMID 7480160  1
1994 Yan C, Bentley JK, Sonnenburg WK, Beavo JA. Differential expression of the 61 kDa and 63 kDa calmodulin-dependent phosphodiesterases in the mouse brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 973-84. PMID 8120637  1
1994 Florio VA, Sonnenburg WK, Johnson R, Kwak KS, Jensen GS, Walsh KA, Beavo JA. Phosphorylation of the 61-kDa calmodulin-stimulated cyclic nucleotide phosphodiesterase at serine 120 reduces its affinity for calmodulin. Biochemistry. 33: 8948-54. PMID 8043581  1
1994 Sonnenburg WK, Beavo JA. Cyclic GMP and regulation of cyclic nucleotide hydrolysis. Advances in Pharmacology (San Diego, Calif.). 26: 87-114. PMID 8038108  1
1994 Beavo JA, Conti M, Heaslip RJ. Multiple cyclic nucleotide phosphodiesterases. Molecular Pharmacology. 46: 399-405. PMID 7935318  1
1993 Chan SC, Reifsnyder D, Beavo JA, Hanifin JM. Immunochemical characterization of the distinct monocyte cyclic AMP-phosphodiesterase from patients with atopic dermatitis. The Journal of Allergy and Clinical Immunology. 91: 1179-88. PMID 8389777 DOI: 10.1016/0091-6749(93)90321-6  1
1993 Michaeli T, Bloom TJ, Martins T, Loughney K, Ferguson K, Riggs M, Rodgers L, Beavo JA, Wigler M. Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae. The Journal of Biological Chemistry. 268: 12925-32. PMID 8389765  1
1993 Hamilton SE, Prusti RK, Bentley JK, Beavo JA, Hurley JB. Affinities of bovine photoreceptor cGMP phosphodiesterases for rod and cone inhibitory subunits. Febs Letters. 318: 157-61. PMID 8382627 DOI: 10.1016/0014-5793(93)80012-J  1
1993 McAllister-Lucas LM, Sonnenburg WK, Kadlecek A, Seger D, Trong HL, Colbran JL, Thomas MK, Walsh KA, Francis SH, Corbin JD. The structure of a bovine lung cGMP-binding, cGMP-specific phosphodiesterase deduced from a cDNA clone. The Journal of Biological Chemistry. 268: 22863-73. PMID 8226796  1
1993 Beltman J, Sonnenburg WK, Beavo JA. The role of protein phosphorylation in the regulation of cyclic nucleotide phosphodiesterases. Molecular and Cellular Biochemistry. 127: 239-53. PMID 7935355 DOI: 10.1007/BF01076775  1
1993 Sonnenburg WK, Seger D, Beavo JA. Molecular cloning of a cDNA encoding the "61-kDa" calmodulin-stimulated cyclic nucleotide phosphodiesterase. Tissue-specific expression of structurally related isoforms. The Journal of Biological Chemistry. 268: 645-52. PMID 7678006  1
1992 Bentley JK, Beavo JA. Regulation and function of cyclic nucleotides. Current Opinion in Cell Biology. 4: 233-40. PMID 1350913 DOI: 10.1016/0955-0674(92)90038-E  1
1992 Bentley JK, Kadlecek A, Sherbert CH, Seger D, Sonnenburg WK, Charbonneau H, Novack JP, Beavo JA. Molecular cloning of cDNA encoding a "63"-kDa calmodulin-stimulated phosphodiesterase from bovine brain. The Journal of Biological Chemistry. 267: 18676-82. PMID 1326531  1
1992 Butt E, Nolte C, Schulz S, Beltman J, Beavo JA, Jastorff B, Walter U. Analysis of the functional role of cGMP-dependent protein kinase in intact human platelets using a specific activator 8-para-chlorophenylthio-cGMP. Biochemical Pharmacology. 43: 2591-600. PMID 1321624 DOI: 10.1016/0006-2952(92)90148-C  1
1992 Stroop SD, Beavo JA. Sequence homology and structure--function studies of the bovine cyclic-GMP-stimulated and retinal phosphodiesterases. Advances in Second Messenger and Phosphoprotein Research. 25: 55-71. PMID 1313272  1
1991 MacFarland RT, Zelus BD, Beavo JA. High concentrations of a cGMP-stimulated phosphodiesterase mediate ANP-induced decreases in cAMP and steroidogenesis in adrenal glomerulosa cells. The Journal of Biological Chemistry. 266: 136-42. PMID 1845962  1
1991 Stroop SD, Beavo JA. Structure and function studies of the cGMP-stimulated phosphodiesterase. The Journal of Biological Chemistry. 266: 23802-9. PMID 1721055  1
1991 Sonnenburg WK, Mullaney PJ, Beavo JA. Molecular cloning of a cyclic GMP-stimulated cyclic nucleotide phosphodiesterase cDNA. Identification and distribution of isozyme variants. The Journal of Biological Chemistry. 266: 17655-61. PMID 1654333  1
1991 Novack JP, Charbonneau H, Bentley JK, Walsh KA, Beavo JA. Sequence comparison of the 63-, 61-, and 59-kDa calmodulin-dependent cyclic nucleotide phosphodiesterases. Biochemistry. 30: 7940-7. PMID 1651112 DOI: 10.1021/bi00246a010  1
1991 Charbonneau H, Kumar S, Novack JP, Blumenthal DK, Griffin PR, Shabanowitz J, Hunt DF, Beavo JA, Walsh KA. Evidence for domain organization within the 61-kDa calmodulin-dependent cyclic nucleotide phosphodiesterase from bovine brain. Biochemistry. 30: 7931-40. PMID 1651111 DOI: 10.1021/bi00246a009  1
1990 Trong HL, Beier N, Sonnenburg WK, Stroop SD, Walsh KA, Beavo JA, Charbonneau H. Amino acid sequence of the cyclic GMP stimulated cyclic nucleotide phosphodiesterase from bovine heart. Biochemistry. 29: 10280-8. PMID 2176866  1
1990 Beavo JA, Reifsnyder DH. Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors. Trends in Pharmacological Sciences. 11: 150-5. PMID 2159198 DOI: 10.1016/0165-6147(90)90066-H  1
1990 Charbonneau H, Prusti RK, LeTrong H, Sonnenburg WK, Mullaney PJ, Walsh KA, Beavo JA. Identification of a noncatalytic cGMP-binding domain conserved in both the cGMP-stimulated and photoreceptor cyclic nucleotide phosphodiesterases. Proceedings of the National Academy of Sciences of the United States of America. 87: 288-92. PMID 2153290  1
1989 Novack JP, Charbonneau H, Blumenthal DK, Walsh KA, Beavo JA. The domain structure of the calmodulin-dependent phosphodiesterase isozymes Advances in Experimental Medicine and Biology. 255: 387-395. PMID 2618869  1
1989 Gillespie PG, Beavo JA. Inhibition and stimulation of photoreceptor phosphodiesterases by dipyridamole and M&B 22,948. Molecular Pharmacology. 36: 773-81. PMID 2555675  1
1989 Stroop SD, Charbonneau H, Beavo JA. Direct photolabeling of the cGMP-stimulated cyclic nucleotide phosphodiesterase. The Journal of Biological Chemistry. 264: 13718-25. PMID 2547773  1
1989 Gillespie PG, Prusti RK, Apel ED, Beavo JA. A soluble form of bovine rod photoreceptor phosphodiesterase has a novel 15-kDa subunit. The Journal of Biological Chemistry. 264: 12187-93. PMID 2545702  1
1989 Gillespie PG, Beavo JA. cGMP is tightly bound to bovine retinal rod phosphodiesterase. Proceedings of the National Academy of Sciences of the United States of America. 86: 4311-5. PMID 2542968  1
1988 Blumenthal DK, Charbonneau H, Edelman AM, Hinds TR, Rosenberg GB, Storm DR, Vincenzi FF, Beavo JA, Krebs EG. Synthetic peptides based on the calmodulin-binding domain of myosin light chain kinase inhibit activation of other calmodulin-dependent enzymes. Biochemical and Biophysical Research Communications. 156: 860-5. PMID 2903735 DOI: 10.1016/S0006-291X(88)80923-9  1
1988 Beavo JA. Multiple isozymes of cyclic nucleotide phosphodiesterase Advances in Second Messenger and Phosphoprotein Research. 22: 1-38. PMID 2852020  1
1988 Harrison SA, Beier N, Martins TJ, Beavo JA. Isolation and comparison of bovine heart cGMP-inhibited and cGMP-stimulated phosphodiesterases Methods in Enzymology. 159: 685-702. PMID 2842630  1
1988 Hansen RS, Charbonneau H, Beavo JA. Purification of calmodulin-stimulated cyclic nucleotide phosphodiesterase by monoclonal antibody affinity chromatography Methods in Enzymology. 159: 543-557. PMID 2842618  1
1988 Macphee CH, Reifsnyder DH, Moore TA, Lerea KM, Beavo JA. Phosphorylation results in activation of a cAMP phosphodiesterase in human platelets Journal of Biological Chemistry. 263: 10353-10358. PMID 2839485  1
1988 Gillespie PG, Beavo JA. Characterization of a bovine cone photoreceptor phosphodiesterase purified by cyclic GMP-sepharose chromatography. The Journal of Biological Chemistry. 263: 8133-41. PMID 2836413  1
1986 Charbonneau H, Beier N, Walsh KA, Beavo JA. Identification of a conserved domain among cyclic nucleotide phosphodiesterases from diverse species Proceedings of the National Academy of Sciences of the United States of America. 83: 9308-9312. PMID 3025833  1
1986 Hansen RS, Beavo JA. Differential recognition of calmodulin-enzyme complexes by a conformation-specific anti-calmodulin monoclonal antibody Journal of Biological Chemistry. 261: 14636-14645. PMID 3021748  1
1986 Macphee CH, Harrison SA, Beavo JA. Immunological identification of the major platelet low-K(m) cAMP phosphodiesterase: Probable target for anti-thrombotic agents Proceedings of the National Academy of Sciences of the United States of America. 83: 6660-6663. PMID 3018742  1
1986 Harrison SA, Reifsnyder DH, Gallis B, Cadd GG, Beavo JA. Isolation and characterization of bovine cardiac muscle cGMP-inhibited phosphodiesterase: A receptor for new cardiotonic drugs Molecular Pharmacology. 29: 506-514. PMID 3010079  1
1986 Harrison SA, Chang ML, Beavo JA. Differential inhibition of cardiac cyclic nucleotide phosphodiesterase isozymes by cardiotonic drugs Circulation. 73: III-109-III-116. PMID 3002661  1
1986 Macphee CH, Reifsnyder DH, Moore TA, Beavo JA. Intact cell and cell-free phosphorylation and concomitant activation of a low K(m), cAMP phosphodiesterase found in human platelets Journal of Cyclic Nucleotide and Protein Phosphorylation Research. 11: 487-496. PMID 2831258  1
1985 Hurwitz RL, Bunt-Milam AH, Chang ML, Beavo JA. cGMP phosphodiesterase in rod and cone outer segments of the retina Journal of Biological Chemistry. 260: 568-573. PMID 2981219  1
1985 Harrison SA, Chang ML, Beavo JA. Investigation of a low Km phosphodiesterase from cardiac muscle using monoclonal antibodies and phosphodiesterase inhibitors Federation Proceedings. 44: No. 1855.  1
1984 Hurwitz RL, Bunt-Milam AH, Beavo JA. Immunologic characterization of the photoreceptor outer segment cyclic GMP phosphodiesterase Journal of Biological Chemistry. 259: 8612-8618. PMID 6330115  1
1984 Hurwitz RL, Hansen RS, Harrison SA, Martins TJ, Mumby MC, Beavo JA. Immunologic approaches to the study of cyclic nucleotide phosphodiesterases. Advances in Cyclic Nucleotide and Protein Phosphorylation Research. 16: 89-106. PMID 6326539  1
1984 Hurwitz RL, Beavo JA. Immunotitration analysis of the rod outer segment phosphodiesterase Advances in Cyclic Nucleotide and Protein Phosphorylation Research. 17: 239-248. PMID 6203341  1
1983 Weldon SL, Mumby MC, Beavo JA, Taylor SS. Monoclonal antibodies as structural probes of surface residues in the regulatory subunit of cAMP-dependent protein kinase II from porcine heart. The Journal of Biological Chemistry. 258: 1129-35. PMID 6185475  1
1982 Mumby MC, Martins TJ, Chang ML, Beavo JA. Identification of cGMP-stimulated cyclic nucleotide phosphodiesterase in lung tissue with monoclonal antibodies. The Journal of Biological Chemistry. 257: 13283-90. PMID 6292183  1
1982 Hansen RS, Beavo JA. Purification of two calcium/calmodulin-dependent forms of cyclic nucleotide phosphodiesterase by using conformation-specific monoclonal antibody chromatography Proceedings of the National Academy of Sciences of the United States of America. 79: 2788-2792. PMID 6283544  1
1982 Doherty PJ, Tsao J, Schimmer BP, Mumby MC, Beavo JA. Alteration of the regulatory subunit of type 1 cAMP-dependent protein kinase in mutant Y1 adrenal cells resistant to 8-bromoadenosine 3':5'-monophosphate. The Journal of Biological Chemistry. 257: 5877-83. PMID 6279618  1
1982 Martins TJ, Mumby MC, Beavo JA. Purification and characterization of a cyclic GMP-stimulated cyclic nucleotide phosphodiesterase from bovine tissues. The Journal of Biological Chemistry. 257: 1973-9. PMID 6276403  1
1982 Beavo JA, Hansen RS, Harrison SA, Hurwitz RL, Martins TJ, Mumby MC. Identification and properties of cyclic nucleotide phosphodiesterases. Molecular and Cellular Endocrinology. 28: 387-410. PMID 6185373 DOI: 10.1016/0303-7207(82)90135-6  1
1982 Foerder CA, Martins TJ, Beavo JA, Krebs EG. Induction of Xenopus laevis oocyte maturation by cyclic GMP-stimulated phosphodiesterase Journal of Cell Biology. 95: no. 15016.  1
1981 Kapoor CL, Beavo JA, Steiner AL. [19] Radioimmunoassay of the regulatory subunit of type I cAMP-dependent protein kinase Methods in Enzymology. 74: 299-310. PMID 7321885 DOI: 10.1016/0076-6879(81)74021-7  1
1981 Koide Y, Beavo JA, Kapoor CL, Spruill WA, Huang HL, Levine SN, Ong SL, Bechtel PJ, Yount WJ, Steiner AL. Hormonal effects on the immunocytochemical location of 3',5'-cyclic adenosine monophosphate-dependent protein kinase in rat tissues Endocrinology. 109: 2226-2238. PMID 6273134  1
1981 Cumming R, Koide Y, Krigman MR, Beavo JA, Steiner AL. The immunofluorescent localization of regulatory and catalytic subunits of cyclic AMP-dependent protein kinase in neuronal and glial cell types of the central nervous system Neuroscience. 6: 953-961. PMID 6264345 DOI: 10.1016/0306-4522(81)90176-7  1
1981 Spruill WA, Koide Y, Huang HL, Levine SN, Ong SH, Steiner AL, Beavo JA. Immunocytochemical localization of cyclic guanosine monophosphate-dependent protein kinase in endocrine tissues Endocrinology. 109: 2239-2248. PMID 6171421  1
1981 Young WJ, Beavo JA, Steiner AJ. Lymphocyte surface modulation and cyclic nucleotides: III. Compartmentalization of second messengers in normal lymphocytes following patch and cap formation of surface immunoglobulin and concanavalin Federation Proceedings. 40: No. 4831.  1
1980 Browne CL, Lockwood AH, Su JL, Beavo JA, Steiner AL. Immunofluorescent localization of cyclic nucleotide-dependent protein kinases on the mitotic apparatus of cultured cells Journal of Cell Biology. 87: 336-345. PMID 7000793 DOI: 10.1083/jcb.87.2.336  1
1980 Mumby M, Beavo JA. Production and characterization of monoclonal antibodies to type II regulatory subunit of cyclic AMP dependent protein kinase Proceedings of the Western Pharmacology Society. 369-373. PMID 6250155  1
1980 Builder SE, Beavo JA, Krebs EG. The mechanism of activation of bovine skeletal muscle protein kinase by adenosine 3':5'-monophosphate. The Journal of Biological Chemistry. 255: 3514-9. PMID 6245082  1
1980 Builder SE, Beavo JA, Krebs EG. Stoichiometry of cAMP and 1,N6-etheno-cAMP binding to protein kinase. The Journal of Biological Chemistry. 255: 2350-4. PMID 6244276  1
1979 Kapoor CL, Beavo JA, Steiner AL. Radioimmunoassay of the regulatory subunit of type I cAMP-dependent protein kinase Journal of Biological Chemistry. 254: 12427-12432. PMID 227895  1
1979 Dills WL, Goodwin CD, Lincoln TM, Beavo JA, Bechtel PJ, Corbin JD, Krebs EG. Purification of cyclic nucleotide receptor proteins by cyclic nucleotide affinity chromatography. Advances in Cyclic Nucleotide Research. 10: 199-217. PMID 222123  1
1979 Krebs EG, Beavo JA. Phosphorylation-dephosphorylation of enzymes. Annual Review of Biochemistry. 48: 923-59. PMID 38740 DOI: 10.1146/annurev.bi.48.070179.004423  1
1979 Kapoor CL, Beavo JA, Steiner AL. Effect of cyclic AMP and skeletal muscle protein kinase catalytic subunit (C) on the immunoreactivity of bovine skeletal muscle protein kinase regulatory subunit (RI) Federation Proceedings. 38: No.200.  1
1977 Bechtel PJ, Beavo JA, Krebs EG. Purification and characterization of catalytic subunit of skeletal muscle adenosine 3':5'-monophosphate-dependent protein kinase. The Journal of Biological Chemistry. 252: 2691-7. PMID 192719  1
1976 Dills WL, Beavo JA, Bechtel PJ, Myers KR, Sakai LJ, Krebs EG. Binding of adenosine 3',5'-monophosphate dependent protein kinase regulatory subunit to immobilized cyclic nucleotide derivatives. Biochemistry. 15: 3724-31. PMID 182216  1
1975 Hofmann F, Beavo JA, Bechtel PJ, Krebs EG. Comparison of adenosine 3':5'-monophosphate-dependent protein kinases from rabbit skeletal and bovine heart muscle. The Journal of Biological Chemistry. 250: 7795-801. PMID 170270  1
1975 Shizuta Y, Beavo JA, Bechtel PJ, Hofmann F, Krebs EG. Reversibility of adenosine 3':5'-monophosphate-dependent protein kinase reactions. The Journal of Biological Chemistry. 250: 6891-6. PMID 169260  1
1975 Beavo JA, Bechtel PJ, Krebs EG. Mechanisms of control for cAMP-dependent protein kinase from skeletal muscle. Advances in Cyclic Nucleotide Research. 5: 241-51. PMID 165668  1
1975 Dills WL, Beavo JA, Bechtel PJ, Krebs EG. Purification of rabbit skeletal muscle protein kinase regulatory subunit using cyclic adenosine-3':5'-monophosphate affinity chromatography. Biochemical and Biophysical Research Communications. 62: 70-7. PMID 163082  1
1974 Beavo JA, Bechtel PJ, Krebs EG. Preparation of homogeneous cyclic AMP-dependent protein kinase(s) and its subunits from rabbit skeletal muscle. Methods in Enzymology. 38: 299-308. PMID 4375763  1
1974 Beavo JA, Bechtel PJ, Krebs EG. Activation of protein kinase by physiological concentrations of cyclic AMP. Proceedings of the National Academy of Sciences of the United States of America. 71: 3580-3. PMID 4372627  1
1971 Hardman JG, Beavo JA, Gray JP, Chrisman TD, Patterson WD, Sutherland EW. The formation and metabolism of cyclic GMP. Annals of the New York Academy of Sciences. 185: 27-35. PMID 4330496  1
1971 Beavo JA, Rogers NL, Crofford OB, Baird CE, Hardman JG, Sutherland EW, Newman EV. Effects of phosphodiesterase inhibitors on cyclic AMP levels and on lipolysis. Annals of the New York Academy of Sciences. 185: 129-36. PMID 4330487  1
1971 Beavo JA, Hardman JG, Sutherland EW. Stimulation of adenosine 3',5'-monophosphate hydrolysis by guanosine 3',5'-monophosphate. The Journal of Biological Chemistry. 246: 3841-6. PMID 4327188  1
1970 Beavo JA, Rogers NL, Crofford OB, Hardman JG, Sutherland EW, Newman EV. Effects of xanthine derivatives on lipolysis and on adenosine 3',5'-monophosphate phosphodiesterase activity. Molecular Pharmacology. 6: 597-603. PMID 4322367  1
1970 Beavo JA, Hardman JG, Sutherland EW. Hydrolysis of cyclic guanosine and adenosine 3',5'-monophosphates by rat and bovine tissues. The Journal of Biological Chemistry. 245: 5649-55. PMID 4319563  1
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