| Year |
Citation |
Score |
| 2023 |
Bahrami K, Kärkkäinen J, Bibi S, Huttunen J, Tampio J, Montaser AB, Moody CL, Lehtonen M, Rautio J, Wheelhouse RT, Huttunen KM. Specific Transport of Temozolomide Does Not Override DNA Repair-mediated Chemoresistance. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 106661. PMID 38052257 DOI: 10.1016/j.ejps.2023.106661 |
0.319 |
|
| 2018 |
Cousin D, Hummersone MG, Bradshaw TD, Zhang J, Moody CJ, Foreiter MB, Summers HS, Lewis W, Wheelhouse RT, Stevens MFG. Synthesis and growth-inhibitory activities of imidazo[5,1-]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and heteromethyl groups at the 3-position. Medchemcomm. 9: 545-553. PMID 30108945 DOI: 10.1039/C7Md00554G |
0.408 |
|
| 2018 |
Allison SJ, Sadiq M, Baronou E, Cooper PA, Dunnill C, Georgopoulos NT, Latif A, Shepherd S, Shnyder SD, Stratford IJ, Wheelhouse RT, Willans CE, Phillips RM. Corrigendum to "Preclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbene ligands" [Canc. Lett. 403 (2017) 98-107]. Cancer Letters. PMID 29934232 DOI: 10.1016/J.Canlet.2018.06.022 |
0.319 |
|
| 2018 |
Rice CR, Allison S, Cooke D, Davidson F, Elliott P, Faulkner R, Griffiths H, Harper O, Hussain O, Owen-Lynch J, Phillips R, Sheperd S, Wheelhouse R. Ruthenium-containing Linear Helicates and Mesocates with Tuneable p53 Selective Cytotoxicity in Colorectal Cancer Cells. Angewandte Chemie (International Ed. in English). PMID 29863754 DOI: 10.1002/Anie.201805510 |
0.305 |
|
| 2017 |
Allison SJ, Sadiq M, Baronou E, Cooper PA, Dunnill C, Georgopoulos NT, Latif A, Shepherd S, Shnyder SD, Stratford IJ, Wheelhouse R, Willans C, Phillips RM. Preclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbene ligands. Cancer Letters. PMID 28624622 DOI: 10.1016/J.Canlet.2017.04.041 |
0.361 |
|
| 2015 |
Evans K, Bhamra I, Wheelhouse RT, Arnold JR, Cosstick R, Fisher J. Stabilization of a Bimolecular Triplex by 3'-S-Phosphorothiolate Modifications: An NMR and UV Thermal Melting Investigation. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 7278-84. PMID 25802084 DOI: 10.1002/Chem.201500369 |
0.406 |
|
| 2015 |
Ramirez YP, Mladek AC, Phillips RM, Gynther M, Rautio J, Ross AH, Wheelhouse RT, Sakaria JN. Evaluation of novel imidazotetrazine analogues designed to overcome temozolomide resistance and glioblastoma regrowth. Molecular Cancer Therapeutics. 14: 111-9. PMID 25351918 DOI: 10.1158/1535-7163.Mct-14-0113 |
0.376 |
|
| 2014 |
Moody CL, Wheelhouse RT. The medicinal chemistry of imidazotetrazine prodrugs Pharmaceuticals. 7: 797-838. DOI: 10.3390/Ph7070797 |
0.404 |
|
| 2013 |
Pletsas D, Garelnabi EA, Li L, Phillips RM, Wheelhouse RT. Synthesis and quantitative structure-activity relationship of imidazotetrazine prodrugs with activity independent of O6-methylguanine-DNA-methyltransferase, DNA mismatch repair, and p53. Journal of Medicinal Chemistry. 56: 7120-32. PMID 23895620 DOI: 10.1021/Jm401121K |
0.44 |
|
| 2013 |
Tuma ACM, Ramirez Y, Pletsas D, Wheelhouse RT, Phillips RM, Alonzo RH, Knudson K, Sarkaria JN. Abstract 4476: Cytotoxicity of a novel bi-functional temozolomide analog, DP68, is independent of MGMT status in glioblastoma models. Cancer Research. 73: 4476-4476. DOI: 10.1158/1538-7445.Am2013-4476 |
0.349 |
|
| 2012 |
Garelnabi EA, Pletsas D, Li L, Kiakos K, Karodia N, Hartley JA, Phillips RM, Wheelhouse RT. Strategy for Imidazotetrazine Prodrugs with Anticancer Activity Independent of MGMT and MMR. Acs Medicinal Chemistry Letters. 3: 965-8. PMID 24900418 DOI: 10.1021/Ml300132T |
0.423 |
|
| 2012 |
Abdallah QM, Phillips RM, Johansson F, Helleday T, Cosentino L, Abdel-Rahman H, Etzad J, Wheelhouse RT, Kiakos K, Bingham JP, Hartley JA, Patterson LH, Pors K. Minor structural modifications to alchemix influence mechanism of action and pharmacological activity. Biochemical Pharmacology. 83: 1514-22. PMID 22387433 DOI: 10.1016/J.Bcp.2012.02.017 |
0.441 |
|
| 2010 |
Wheelhouse RT, Garbett NC, Buurma NJ, Chaires JB. Probing the molecular recognition of a DNA.RNA hybrid duplex. Angewandte Chemie (International Ed. in English). 49: 3207-10. PMID 20352639 DOI: 10.1002/Anie.200907235 |
0.361 |
|
| 2010 |
Wheelhouse RT, Chaires JB. Drug binding to DNA x RNA hybrid structures. Methods in Molecular Biology (Clifton, N.J.). 613: 55-70. PMID 19997877 DOI: 10.1007/978-1-60327-418-0_4 |
0.346 |
|
| 2009 |
Evans HR, Rong D, Phillips RM, Sutton CW, Wheelhouse RT. Abstract A204: Investigating a novel antitumor molecular target using a chemical proteomic strategy Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-A204 |
0.348 |
|
| 2007 |
Banks EC, Doughty SW, Toms SM, Wheelhouse RT, Nicolaou A. Inhibition of cobalamin-dependent methionine synthase by substituted benzo-fused heterocycles Febs Journal. 274: 287-299. PMID 17222188 DOI: 10.1111/J.1742-4658.2006.05583.X |
0.351 |
|
| 2006 |
Wheelhouse RT, Jennings SA, Phillips VA, Pletsas D, Murphy PM, Garbett NC, Chaires JB, Jenkins TC. Design, synthesis, and evaluation of novel biarylpyrimidines: A new class of ligand for unusual nucleic acid structures Journal of Medicinal Chemistry. 49: 5187-5198. PMID 16913707 DOI: 10.1021/Jm060315A |
0.345 |
|
| 2006 |
Pletsas D, Wheelhouse RT, Pletsa V, Nicolaou A, Jenkins TC, Bibby MC, Kyrtopoulos SA. Polar, functionalized guanine-O6 derivatives resistant to repair by O6-alkylguanine–DNA alkyltransferase: implications for the design of DNA-modifying drugs European Journal of Medicinal Chemistry. 41: 330-339. PMID 16458393 DOI: 10.1016/J.Ejmech.2005.11.007 |
0.393 |
|
| 2004 |
Shoeib NA, Bibby MC, Blunden G, Linley PA, Swaine DJ, Wheelhouse RT, Wright CW. In-vitro cytotoxic activities of the major bromophenols of the red alga Polysiphonia lanosa and some novel synthetic isomers. Journal of Natural Products. 67: 1445-9. PMID 15387639 DOI: 10.1021/Np0305268 |
0.345 |
|
| 2003 |
Murphy PM, Phillips VA, Jennings SA, Garbett NC, Chaires JB, Jenkins TC, Wheelhouse RT. Biarylpyrimidines: a new class of ligand for high-order DNA recognition. Chemical Communications (Cambridge, England). 1160-1. PMID 12778714 DOI: 10.1039/B301554H |
0.407 |
|
| 2002 |
Vaughan K, Wilman DEV, Wheelhouse RT, Stevens MFG. A15N NMR investigation of a series of benzotriazinones and related antitumour heterocycles Magnetic Resonance in Chemistry. 40: 300-302. DOI: 10.1002/Mrc.994 |
0.321 |
|
| 2001 |
Shi DF, Wheelhouse RT, Sun D, Hurley LH. Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase. Journal of Medicinal Chemistry. 44: 4509-23. PMID 11741471 DOI: 10.1021/Jm010246U |
0.583 |
|
| 2000 |
Hurley LH, Wheelhouse RT, Sun D, Kerwin SM, Salazar M, Fedoroff OY, Han FX, Han H, Izbicka E, Von Hoff DD. G-quadruplexes as targets for drug design. Pharmacology & Therapeutics. 85: 141-58. PMID 10739869 DOI: 10.1016/S0163-7258(99)00068-6 |
0.544 |
|
| 2000 |
Arrowsmith J, Jennings SA, Langnel DAF, Wheelhouse RT, Stevens MFG. Antitumour imidazotetrazines. Part 39. Synthesis of bis(imidazotetrazine)s with saturated spacer groups Journal of the Chemical Society, Perkin Transactions 1. 4432-4438. DOI: 10.1039/B005652I |
0.404 |
|
| 1999 |
Han FX, Wheelhouse RT, Hurley LH. Interactions of TMPyP4 and TMPyP2 with quadruplex DNA. Structural basis for the differential effects on telomerase inhibition Journal of the American Chemical Society. 121: 3561-3570. DOI: 10.1021/Ja984153M |
0.565 |
|
| 1998 |
Moore BM, Seaman FC, Wheelhouse RT, Hurley LH. Mechanism for the catalytic activation of ecteinascidin 743 and its subsequent alkylation of guanine N2 Journal of the American Chemical Society. 120: 2490-2491. DOI: 10.1021/Ja974109R |
0.501 |
|
| 1998 |
Wheelhouse RT, Sun D, Han H, Han FX, Hurley LH. Cationic porphyrins as telomerase inhibitors: The interaction of tetra- (N-methyl-4-pyridyl)porphine with quadruplex DNA [1] Journal of the American Chemical Society. 120: 3261-3262. DOI: 10.1021/Ja973792E |
0.568 |
|
| 1997 |
Newlands ES, Stevens MF, Wedge SR, Wheelhouse RT, Brock C. Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials. Cancer Treatment Reviews. 23: 35-61. PMID 9189180 DOI: 10.1016/S0305-7372(97)90019-0 |
0.496 |
|
| 1996 |
Wheelhouse RT, Shi D, Wilman DEV, Stevens MFG. Antitumour benzothiazoles. Part 4. An NMR study of the sites of protonation of 2-(4-aminophenyl)benzothiazoles Journal of the Chemical Society-Perkin Transactions 1. 1271-1274. DOI: 10.1039/P29960001271 |
0.338 |
|
| 1995 |
Clark AS, Deans B, Stevens MF, Tisdale MJ, Wheelhouse RT, Denny BJ, Hartley JA. Antitumor imidazotetrazines. 32. Synthesis of novel imidazotetrazinones and related bicyclic heterocycles to probe the mode of action of the antitumor drug temozolomide. Journal of Medicinal Chemistry. 38: 1493-504. PMID 7739008 DOI: 10.1021/Jm00009A010 |
0.606 |
|
| 1995 |
Wheelhouse RT, Wilman DEV, Thomson W, Stevens MFG. Antitumour imidazotetrazines. Part 31. The synthesis of isotopically labelled temozolomide and a multinuclear (1H, 13C, 15N) magnetic resonance investigation of temozolomide and mitozolomide Journal of the Chemical Society-Perkin Transactions 1. 249-252. DOI: 10.1039/P19950000249 |
0.301 |
|
| 1994 |
Denny BJ, Wheelhouse RT, Stevens MF, Tsang LL, Slack JA. NMR and molecular modeling investigation of the mechanism of activation of the antitumor drug temozolomide and its interaction with DNA. Biochemistry. 33: 9045-51. PMID 8049205 DOI: 10.1021/Bi00197A003 |
0.609 |
|
| 1993 |
Wheelhouse RT, Stevens MFG. Decomposition of the antitumour drug temozolomide in deuteriated phosphate buffer: methyl group transfer is accompanied by deuterium exchange Journal of the Chemical Society, Chemical Communications. 1177-1178. DOI: 10.1039/C39930001177 |
0.315 |
|
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