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Theodore R. Holman - Publications

Affiliations: 
Chemistry & Biochemistry University of California, Santa Cruz, Santa Cruz, CA, United States 
Area:
lipoxygenase
Website:
http://www.chemistry.ucsc.edu/faculty/singleton.php?&singleton=true&cruz_id=holman

108 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Tsai WC, Gilbert NC, Ohler A, Armstrong M, Perry S, Kalyanaraman C, Yasgar A, Rai G, Simeonov A, Jadhav A, Standley M, Lee HW, Crews P, Iavarone AT, Jacobson MP, ... ... Holman TR, et al. Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2. Bioorganic & Medicinal Chemistry. 46: 116349. PMID 34500187 DOI: 10.1016/j.bmc.2021.116349  1
2021 Tsai WC, Kalyanaraman C, Yamaguchi A, Holinstat M, Jacobson MP, Holman TR. Biosynthetic Pathway Investigations of Neuroprotectin D1 (NPD1) and Protectin DX (PDX) by Human 12-Lipoxygenase, 15-Lipoxygenase-1, and 15-Lipoxygenase-2. Biochemistry. PMID 34029049 DOI: 10.1021/acs.biochem.0c00931  1
2020 Yamaguchi A, Stanger L, Freedman CJ, Standley M, Hoang T, Adili R, Tsai WC, van Hoorebeke C, Holman TR, Holinstat M. DHA 12-LOX-derived oxylipins regulate platelet activation and thrombus formation through a PKA-dependent signaling pathway. Journal of Thrombosis and Haemostasis : Jth. PMID 33222370 DOI: 10.1111/jth.15184  1
2020 Anthonymuthu TS, Tyurina YY, Sun WY, Mikulska-Ruminska K, Shrivastava IH, Tyurin VA, Cinemre FB, Dar HH, VanDemark AP, Holman TR, Sadovsky Y, Stockwell BR, He RR, Bahar I, Bayır H, et al. Resolving the paradox of ferroptotic cell death: Ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects against ferroptosis. Redox Biology. 38: 101744. PMID 33126055 DOI: 10.1016/j.redox.2020.101744  0.04
2020 Perry SC, Horn T, Tourdot BE, Yamaguchi A, Kalyanaraman C, Conrad WS, Akinkugbe O, Holinstat M, Jacobson MP, Holman TR. Role of Human 15-Lipoxygenase-2 in the Biosynthesis of the Lipoxin Intermediate, 5S,15S-diHpETE, Implicated with the Altered Positional Specificity of Human 15-Lipoxygenase-1. Biochemistry. PMID 33048542 DOI: 10.1021/acs.biochem.0c00622  1
2020 Yeung J, Adili R, Yamaguchi A, Freedman CJ, Chen A, Shami R, Das A, Holman TR, Holinstat M. Omega-6 DPA and its 12-lipoxygenase-oxidized lipids regulate platelet reactivity in a nongenomic PPARα-dependent manner. Blood Advances. 4: 4522-4537. PMID 32946570 DOI: 10.1182/Bloodadvances.2020002493  1
2020 Offenbacher AR, Holman TR. Fatty Acid Allosteric Regulation of C-H Activation in Plant and Animal Lipoxygenases. Molecules (Basel, Switzerland). 25. PMID 32722330 DOI: 10.3390/Molecules25153374  0.01
2020 Perry SC, Kalyanaraman C, Tourdot BE, Conrad WS, Akinkugbe O, Freedman JC, Holinstat M, Jacobson MP, Holman TR. 15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-Lipoxygenase-2 in biosynthesis of resolvin D5. Journal of Lipid Research. PMID 32404334 DOI: 10.1194/Jlr.Ra120000777  1
2020 Freedman CJ, Tran A, Tourdot BE, Kalyanaraman C, Perry S, Holinstat M, Jacobson MP, Holman TR. Biosynthesis of the Maresin Intermediate, 13S,14S-epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and its Regulation through Negative Allosteric Modulators. Biochemistry. PMID 32324389 DOI: 10.1021/Acs.Biochem.0C00233  1
2019 Zheng Y, Liu Y, Karatas H, Yigitkanli K, Holman TR, van Leyen K. Contributions of 12/15-Lipoxygenase to Bleeding in the Brain Following Ischemic Stroke. Advances in Experimental Medicine and Biology. 1161: 125-131. PMID 31562627 DOI: 10.1007/978-3-030-21735-8_12  1
2018 Aleem A, Tsai WC, Tena J, Alvarez G, Deschamps J, Kalyanaraman C, Jacobson MP, Holman TR. Probing the Electrostatic and Steric Requirements for Substrate Binding in Human Platelet-type 12-Lipoxygenase. Biochemistry. PMID 30565457 DOI: 10.1021/Acs.Biochem.8B01167  1
2018 Green AR, Freedman CJ, Tena J, Tourdot BE, Liu B, Holinstat M, Holman TR. 5S,15S-Dihydroperoxyeicosatetraenoic acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase-1. Biochemistry. PMID 30407793 DOI: 10.1021/Acs.Biochem.8B00889  1
2018 Dobrian AD, Morris MA, Taylor-Fishwick DA, Holman TR, Imai Y, Mirmira RG, Nadler JL. Role of the 12-Lipoxygenase Pathway in Diabetes Pathogenesis and Complications. Pharmacology & Therapeutics. PMID 30347209 DOI: 10.1016/j.pharmthera.2018.10.010  1
2018 Karuppagounder SS, Alin L, Chen Y, Brand D, Bourassa MW, Dietrich K, Wilkinson CM, Nadeau CA, Kumar A, Perry S, Pinto JT, Darley-Usmar V, Sanchez S, Milne GL, Pratico D, ... Holman TR, et al. N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with PGE to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice. Annals of Neurology. PMID 30294906 DOI: 10.1002/Ana.25356  1
2018 Dar HH, Tyurina YY, Mikulska-Ruminska K, Shrivastava I, Ting HC, Tyurin VA, Krieger J, St Croix CM, Watkins S, Bayir E, Mao G, Ambruster C, Kapralov A, Wang H, Parsek MH, ... ... Holman TR, et al. Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium. The Journal of Clinical Investigation. PMID 30198910 DOI: 10.1172/Jci99490  1
2017 Tourdot BE, Adili R, Isingizwe ZR, Ebrahem M, Freedman JC, Holman TR, Holinstat M. 12-HETrE inhibits platelet reactivity and thrombosis in part through the prostacyclin receptor. Blood Advances. 1: 1124-1131. PMID 29296755 DOI: 10.1182/Bloodadvances.2017006155  1
2017 Wenzel SE, Tyurina YY, Zhao J, St Croix CM, Dar HH, Mao G, Tyurin VA, Anthonymuthu TS, Kapralov AA, Amoscato AA, Mikulska-Ruminska K, Shrivastava IH, Kenny EM, Yang Q, Rosenbaum JC, ... ... Holman TR, et al. PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals. Cell. 171: 628-641.e26. PMID 29053969 DOI: 10.1016/J.Cell.2017.09.044  0.01
2017 Adili R, Tourdot BE, Mast K, Yeung J, Freedman JC, Green A, Luci DK, Jadhav A, Simeonov A, Maloney DJ, Holman TR, Holinstat M. First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on Hemostasis. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 28775075 DOI: 10.1161/Atvbaha.117.309868  1
2016 Armstrong M, van Hoorebeke C, Horn T, Deschamps J, Freedman JC, Kalyanaraman C, Jacobson MP, Holman T. Human 15-LOX-1 active site mutations alter inhibitor binding and decrease potency. Bioorganic & Medicinal Chemistry. PMID 27647374 DOI: 10.1016/J.Bmc.2016.08.063  1
2016 Yeung J, Tourdot BE, Adili R, Green AR, Freedman CJ, Fernandez-Perez P, Yu J, Holman TR, Holinstat M. 12-HETrE, a 12-Lipoxygenase Oxylipin of Dihomo-γ-Linolenic Acid, Inhibits Thrombosis via Gαs Signaling in Platelets. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 27470510 DOI: 10.1161/Atvbaha.116.308050  1
2016 Warrilow AG, Price CL, Parker JE, Rolley NJ, Smyrniotis CJ, Hughes DD, Thoss V, Nes WD, Kelly DE, Holman TR, Kelly SL. Azole Antifungal Sensitivity of Sterol 14α-Demethylase (CYP51) and CYP5218 from Malassezia globosa. Scientific Reports. 6: 27690. PMID 27291783 DOI: 10.1038/Srep27690  1
2016 Deschamps JD, Ogunsola AF, Jameson JB, Yasgar A, Flitter BA, Freedman CJ, Melvin JA, Maloney DJ, Jadhav A, Simeonov A, Bomberger JM, Holman TR, Nguyen JV. Biochemical/Cellular Characterization and Inhibitor discovery of Pseudomonas aeruginosa 15-Lipoxygenase. Biochemistry. PMID 27226387 DOI: 10.1021/Acs.Biochem.6B00338  1
2016 Green AR, Barbour SR, Horn T, Carlos J, Raskatov JA, Holman TR. Strict Regio-specificity of Human Epithelial 15-Lipoxygenase-2 Delineates its Transcellular Synthesis Potential. Biochemistry. PMID 27145229 DOI: 10.1021/Acs.Biochem.5B01339  1
2016 Karuppagounder SS, Alim I, Khim SJ, Bourassa MW, Sleiman SF, John R, Thinnes CC, Yeh TL, Demetriades M, Neitemeier S, Cruz D, Gazaryan I, Killilea DW, Morgenstern L, Xi G, ... ... Holman TR, et al. Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models. Science Translational Medicine. 8: 328ra29. PMID 26936506 DOI: 10.1126/Scitranslmed.Aac6008  1
2016 Armstrong MM, Freedman CJ, Jung JE, Zheng Y, Kalyanaraman C, Jacobson MP, Simeonov A, Maloney DJ, van Leyen K, Jadhav A, Holman TR. A potent and selective inhibitor targeting human and murine 12/15-LOX. Bioorganic & Medicinal Chemistry. PMID 26899595 DOI: 10.1016/J.Bmc.2016.01.042  1
2015 Tersey SA, Bolanis E, Holman TR, Maloney DJ, Nadler JL, Mirmira RG. Minireview: 12-Lipoxygenase and Islet β-Cell Dysfunction in Diabetes. Molecular Endocrinology (Baltimore, Md.). 29: 791-800. PMID 25803446 DOI: 10.1210/me.2015-1041  1
2015 Jameson JB, Kenyon V, Holman TR. A high-throughput mass spectrometric assay for discovery of human lipoxygenase inhibitors and allosteric effectors. Analytical Biochemistry. 476: 45-50. PMID 25712042 DOI: 10.1016/J.Ab.2015.02.011  1
2015 Taylor-Fishwick DA, Weaver J, Glenn L, Kuhn N, Rai G, Jadhav A, Simeonov A, Dudda A, Schmoll D, Holman TR, Maloney DJ, Nadler JL. Selective inhibition of 12-lipoxygenase protects islets and beta cells from inflammatory cytokine-mediated beta cell dysfunction. Diabetologia. 58: 549-57. PMID 25417214 DOI: 10.1007/s00125-014-3452-0  1
2015 Mascayano C, Espinosa V, Sepúlveda-Boza S, Hoobler EK, Perry S, Diaz G, Holman TR. Enzymatic Studies of Isoflavonoids as Selective and Potent Inhibitors of Human Leukocyte 5-Lipo-Oxygenase. Chemical Biology & Drug Design. 86: 114-21. PMID 25359714 DOI: 10.1111/Cbdd.12469  1
2015 Tersey SA, Bolanis E, Holman TR, Maloney DJ, Nadler JL, Mirmira RG. Minireview: 12-lipoxygenase and islet β-cell dysfunction in diabetes Molecular Endocrinology. 29: 791-800. DOI: 10.1210/me.2015-1041  1
2015 Mascayano C, Espinosa V, Sepúlveda-Boza S, Hoobler EK, Perry S, Diaz G, Holman TR. Enzymatic studies of isoflavonoids as selective and potent inhibitors of human leukocyte 5-lipo-oxygenase Chemical Biology and Drug Design. 86: 894-901. DOI: 10.1111/cbdd.12469  1
2015 Jameson JB, Kenyon V, Holman TR. A high-throughput mass spectrometric assay for discovery of human lipoxygenase inhibitors and allosteric effectors Analytical Biochemistry. 476: 45-50. DOI: 10.1016/j.ab.2015.02.011  1
2014 van Leyen K, Holman TR, Maloney DJ. The potential of 12/15-lipoxygenase inhibitors in stroke therapy. Future Medicinal Chemistry. 6: 1853-5. PMID 25495979 DOI: 10.4155/Fmc.14.129  1
2014 Jameson JB, Kantz A, Schultz L, Kalyanaraman C, Jacobson MP, Maloney DJ, Jadhav A, Simeonov A, Holman TR. A high throughput screen identifies potent and selective inhibitors to human epithelial 15-lipoxygenase-2. Plos One. 9: e104094. PMID 25111178 DOI: 10.1371/Journal.Pone.0104094  1
2014 Yeung J, Tourdot BE, Fernandez-Perez P, Vesci J, Ren J, Smyrniotis CJ, Luci DK, Jadhav A, Simeonov A, Maloney DJ, Holman TR, McKenzie SE, Holinstat M. Platelet 12-LOX is essential for FcγRIIa-mediated platelet activation. Blood. 124: 2271-9. PMID 25100742 DOI: 10.1182/Blood-2014-05-575878  1
2014 Armstrong MM, Diaz G, Kenyon V, Holman TR. Inhibitory and mechanistic investigations of oxo-lipids with human lipoxygenase isozymes. Bioorganic & Medicinal Chemistry. 22: 4293-7. PMID 24924423 DOI: 10.1016/J.Bmc.2014.05.025  1
2014 Smyrniotis CJ, Barbour SR, Xia Z, Hixon MS, Holman TR. ATP allosterically activates the human 5-lipoxygenase molecular mechanism of arachidonic acid and 5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid. Biochemistry. 53: 4407-19. PMID 24893149 DOI: 10.1021/Bi401621D  1
2014 Rai G, Joshi N, Jung JE, Liu Y, Schultz L, Yasgar A, Perry S, Diaz G, Zhang Q, Kenyon V, Jadhav A, Simeonov A, Lo EH, van Leyen K, Maloney DJ, ... Holman TR, et al. Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies. Journal of Medicinal Chemistry. 57: 4035-48. PMID 24684213 DOI: 10.1021/Jm401915R  1
2014 Chou VP, Ko N, Holman TR, Manning-BoÄŸ AB. Gene-environment interaction models to unmask susceptibility mechanisms in Parkinson's disease. Journal of Visualized Experiments : Jove. e50960. PMID 24430802 DOI: 10.3791/50960  1
2014 Luci DK, Jameson JB, Yasgar A, Diaz G, Joshi N, Kantz A, Markham K, Perry S, Kuhn N, Yeung J, Kerns EH, Schultz L, Holinstat M, Nadler JL, Taylor-Fishwick DA, ... ... Holman TR, et al. Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase. Journal of Medicinal Chemistry. 57: 495-506. PMID 24393039 DOI: 10.1021/Jm4016476  1
2014 Van Leyen K, Holman TR, Maloney DJ. The potential of 12/15-lipoxygenase inhibitors in stroke therapy Future Medicinal Chemistry. 6: 1853-1855. DOI: 10.4155/fmc.14.129  1
2014 Jameson JB, Kantz A, Schultz L, Kalyanaraman C, Jacobson MP, Maloney DJ, Jadhav A, Simeonov A, Holman TR. Steady-state kinetics data for the determination of K i for 15-LOX-2 with MLS000536924. Plos One. DOI: 10.1371/Journal.Pone.0104094.G005  1
2014 Armstrong MM, Diaz G, Kenyon V, Holman TR. Inhibitory and mechanistic investigations of oxo-lipids with human lipoxygenase isozymes Bioorganic and Medicinal Chemistry. 22: 4293-4297. DOI: 10.1016/j.bmc.2014.05.025  1
2013 Joshi N, Hoobler EK, Perry S, Diaz G, Fox B, Holman TR. Kinetic and structural investigations into the allosteric and pH effect on the substrate specificity of human epithelial 15-lipoxygenase-2. Biochemistry. 52: 8026-35. PMID 24171444 DOI: 10.1021/Bi4010649  1
2013 Hoobler EK, Rai G, Warrilow AG, Perry SC, Smyrniotis CJ, Jadhav A, Simeonov A, Parker JE, Kelly DE, Maloney DJ, Kelly SL, Holman TR. Discovery of a novel dual fungal CYP51/human 5-lipoxygenase inhibitor: implications for anti-fungal therapy. Plos One. 8: e65928. PMID 23826084 DOI: 10.1371/Journal.Pone.0065928  1
2013 Yeung J, Apopa PL, Vesci J, Stolla M, Rai G, Simeonov A, Jadhav A, Fernandez-Perez P, Maloney DJ, Boutaud O, Holman TR, Holinstat M. 12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity Thrombosis and Haemostasis. 110: 569-581. PMID 23784669 DOI: 10.1160/Th13-01-0014  1
2013 Hoobler EK, Holz C, Holman TR. Pseudoperoxidase investigations of hydroperoxides and inhibitors with human lipoxygenases Bioorganic and Medicinal Chemistry. 21: 3894-3899. PMID 23669189 DOI: 10.1016/J.Bmc.2013.04.016  1
2013 Yigitkanli K, Pekcec A, Karatas H, Pallast S, Mandeville E, Joshi N, Smirnova N, Gazaryan I, Ratan RR, Witztum JL, Montaner J, Holman TR, Lo EH, van Leyen K. Inhibition of 12/15-lipoxygenase as therapeutic strategy to treat stroke. Annals of Neurology. 73: 129-35. PMID 23192915 DOI: 10.1002/Ana.23734  1
2013 Chou VP, Holman TR, Manning-Bog AB. Differential contribution of lipoxygenase isozymes to nigrostriatal vulnerability. Neuroscience. 228: 73-82. PMID 23079635 DOI: 10.1016/j.neuroscience.2012.10.009  1
2013 Pekcec A, Yigitkanli K, Jung JE, Pallast S, Xing C, Antipenko A, Minchenko M, Nikolov DB, Holman TR, Lo EH, Van Leyen K. Following experimental stroke, the recovering brain is vulnerable to lipoxygenase-dependent semaphorin signaling Faseb Journal. 27: 437-445. PMID 23070608 DOI: 10.1096/fj.12-20689  1
2012 Ikei KN, Yeung J, Apopa PL, Ceja J, Vesci J, Holman TR, Holinstat M. Investigations of human platelet-type 12-lipoxygenase: Role of lipoxygenase products in platelet activation Journal of Lipid Research. 53: 2546-2559. PMID 22984144 DOI: 10.1194/Jlr.M026385  1
2012 Weaver JR, Holman TR, Imai Y, Jadhav A, Kenyon V, Maloney DJ, Nadler JL, Rai G, Simeonov A, Taylor-Fishwick DA. Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction. Molecular and Cellular Endocrinology. 358: 88-95. PMID 22502743 DOI: 10.1016/J.Mce.2012.03.004  1
2012 Yeung J, Apopa PL, Vesci J, Kenyon V, Rai G, Jadhav A, Simeonov A, Holman TR, Maloney DJ, Boutaud O, Holinstat M. Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation Molecular Pharmacology. 81: 420-430. PMID 22155783 DOI: 10.1124/Mol.111.075630  1
2011 Kenyon V, Rai G, Jadhav A, Schultz L, Armstrong M, Jameson JB, Perry S, Joshi N, Bougie JM, Leister W, Taylor-Fishwick DA, Nadler JL, Holinstat M, Simeonov A, Maloney DJ, ... Holman TR, et al. Discovery of potent and selective inhibitors of human platelet-type 12-lipoxygenase Journal of Medicinal Chemistry. 54: 5485-5497. PMID 21739938 DOI: 10.1021/Jm2005089  1
2010 Rai G, Kenyon V, Jadhav A, Schultz L, Armstrong M, Jameson JB, Hoobler E, Leister W, Simeonov A, Holman TR, Maloney DJ. Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1 Journal of Medicinal Chemistry. 53: 7392-7404. PMID 20866075 DOI: 10.1021/Jm1008852  1
2009 Robinson SJ, Hoobler EK, Riener M, Loveridge ST, Tenney K, Valeriote FA, Holman TR, Crews P. Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. Journal of Natural Products. 72: 1857-63. PMID 19848434 DOI: 10.1021/Np900465E  1
2009 Wecksler AT, Garcia NK, Holman TR. Substrate specificity effects of lipoxygenase products and inhibitors on soybean lipoxygenase-1 Bioorganic and Medicinal Chemistry. 17: 6534-6539. PMID 19716306 DOI: 10.1016/J.Bmc.2009.08.005  1
2009 Wecksler AT, Kenyon V, Garcia NK, Deschamps JD, Van Der Donk WA, Holman TR. Kinetic and structural investigations of the allosteric site in human epithelial 15-lipoxygenase-2 Biochemistry. 48: 8721-8730. PMID 19645454 DOI: 10.1021/Bi9009242  1
2009 Wecksler AT, Jacquot C, Van Der Donk WA, Holman TR. Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid Biochemistry. 48: 6259-6267. PMID 19469483 DOI: 10.1021/Bi802332J  1
2008 Jacquot C, McGinley CM, Plata E, Holman TR, van der Donk WA. Synthesis of 11-thialinoleic acid and 14-thialinoleic acid, inhibitors of soybean and human lipoxygenases. Organic & Biomolecular Chemistry. 6: 4242-52. PMID 18972057 DOI: 10.1039/B808003H  1
2008 Sarangi R, Hocking RK, Neidig ML, Benfatto M, Holman TR, Solomon EI, Hodgson KO, Hedman B. Geometric structure determination of N694C lipoxygenase: a comparative near-edge X-ray absorption spectroscopy and extended X-ray absorption fine structure study. Inorganic Chemistry. 47: 11543-50. PMID 18656914 DOI: 10.1021/Ic800580F  1
2008 Wecksler AT, Kenyon V, Deschamps JD, Holman TR. Substrate specificity changes for human reticulocyte and epithelial 15-lipoxygenases reveal allosteric product regulation Biochemistry. 47: 7364-7375. PMID 18570379 DOI: 10.1021/Bi800550N  1
2008 Jacquot C, Wecksler AT, McGinley CM, Segraves EN, Holman TR, van der Donk WA. Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenases. Biochemistry. 47: 7295-303. PMID 18547056 DOI: 10.1021/Bi800308Q  1
2008 van Leyen K, Arai K, Jin G, Kenyon V, Gerstner B, Rosenberg PA, Holman TR, Lo EH. Novel lipoxygenase inhibitors as neuroprotective reagents. Journal of Neuroscience Research. 86: 904-9. PMID 17960827 DOI: 10.1002/jnr.21543  1
2007 Thompson AM, Reddi AR, Shi X, Goldbeck RA, Moënne-Loccoz P, Gibney BR, Holman TR. Measurement of the heme affinity for yeast dap1p, and its importance in cellular function. Biochemistry. 46: 14629-37. PMID 18031064 DOI: 10.1021/Bi7013739  1
2007 Boot CM, Gassner NC, Compton JE, Tenney K, Tamble CM, Lokey RS, Holman TR, Crews P. Pinpointing pseurotins from a marine-derived Aspergillus as tools for chemical genetics using a synthetic lethality yeast screen Journal of Natural Products. 70: 1672-1675. PMID 17929896 DOI: 10.1021/Np070307C  1
2007 Vasquez-Martinez Y, Ohri RV, Kenyon V, Holman TR, Sepúlveda-Boza S. Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2 Bioorganic and Medicinal Chemistry. 15: 7408-7425. PMID 17869117 DOI: 10.1016/J.Bmc.2007.07.036  1
2007 Deschamps JD, Gautschi JT, Whitman S, Johnson TA, Gassner NC, Crews P, Holman TR. Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorganic & Medicinal Chemistry. 15: 6900-8. PMID 17826100 DOI: 10.1016/J.Bmc.2007.08.015  1
2007 Neidig ML, Wecksler AT, Schenk G, Holman TR, Solomon EI. Kinetic and spectroscopic studies of N694C lipoxygenase: A probe of the substrate activation mechanism of a nonheme ferric enzyme Journal of the American Chemical Society. 129: 7531-7537. PMID 17523638 DOI: 10.1021/Ja068503D  1
2007 Gassner NC, Tamble CM, Bock JE, Cotton N, White KN, Tenney K, St. Onge RP, Proctor MJ, Giaever G, Nislow C, Davis RW, Crews P, Holman TR, Lokey RS. Accelerating the discovery of biologically active small molecules using a high-throughput yeast halo assay Journal of Natural Products. 70: 383-390. PMID 17291044 DOI: 10.1021/Np060555T  1
2007 Ralifo P, Sanchez L, Gassner NC, Tenney K, Lokey RS, Holman TR, Valeriote FA, Crews P. Pyrroloacridine alkaloids from Plakortis quasiamphiaster: Structures and bioactivity Journal of Natural Products. 70: 95-99. PMID 17253856 DOI: 10.1021/Np060585W  1
2006 Segraves EN, Chruszcz M, Neidig ML, Ruddat V, Zhou J, Wecksler AT, Minor W, Solomon EI, Holman TR. Kinetic, spectroscopic, and structural investigations of the soybean lipoxygenase-1 first-coordination sphere mutant, Asn694Gly Biochemistry. 45: 10233-10242. PMID 16922498 DOI: 10.1021/Bi060577E  1
2006 Deschamps JD, Kenyon VA, Holman TR. Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases Bioorganic and Medicinal Chemistry. 14: 4295-4301. PMID 16500106 DOI: 10.1016/J.Bmc.2006.01.057  1
2006 Kenyon V, Chorny I, Carvajal WJ, Holman TR, Jacobson MP. Novel human lipoxygenase inhibitors discovered using virtual screening with homology models Journal of Medicinal Chemistry. 49: 1356-1363. PMID 16480270 DOI: 10.1021/Jm050639J  1
2006 O'Halloran C, Silver MW, Holman TR, Scholin CA. Heterosigma akashiwo in central California waters Harmful Algae. 5: 124-132. DOI: 10.1016/J.Hal.2005.06.009  1
2005 Ghosh K, Thompson AM, Goldbeck RA, Shi X, Whitman S, Oh E, Zhiwu Z, Vulpe C, Holman TR. Spectroscopic and biochemical characterization of heme binding to yeast Dap1p and mouse PGRMC1p Biochemistry. 44: 16729-16736. PMID 16342963 DOI: 10.1021/Bi0511585  1
2005 Cichewicz RH, Clifford LJ, Lassen PR, Cao X, Freedman TB, Nafie LA, Deschamps JD, Kenyon VA, Flanary JR, Holman TR, Crews P. Stereochemical determination and bioactivity assessment of (S)-(+)-curcuphenol dimers isolated from the marine sponge Didiscus aceratus and synthesized through laccase biocatalysis. Bioorganic & Medicinal Chemistry. 13: 5600-12. PMID 16039133 DOI: 10.1016/J.Bmc.2005.06.020  1
2005 Ohri RV, Radosevich AT, Hrovat KJ, Musich C, Huang D, Holman TR, Toste FD. A Re(V)-catalyzed C-N bond-forming route to human lipoxygenase inhibitors. Organic Letters. 7: 2501-4. PMID 15932233 DOI: 10.1021/Ol050897A  1
2005 Ruddat VC, Whitman S, Klein RD, Fischer SM, Holman TR. Evidence for downregulation of calcium signaling proteins in advanced mouse adenocarcinoma Prostate. 64: 128-138. PMID 15666362 DOI: 10.1002/Pros.20207  1
2004 Cichewicz RH, Kenyon VA, Whitman S, Morales NM, Arguello JF, Holman TR, Crews P. Redox inactivation of human 15-lipoxygenase by marine-derived meroditerpenes and synthetic chromanes: Archetypes for a unique class of selective and recyclable inhibitors Journal of the American Chemical Society. 126: 14910-14920. PMID 15535718 DOI: 10.1021/Ja046082Z  1
2004 Ruddat VC, Mogul R, Chorny I, Chen C, Perrin N, Whitman S, Kenyon V, Jacobson MP, Bernasconi CF, Holman TR. Tryptophan 500 and arginine 707 define product and substrate active site binding in soybean lipoxygenase-1 Biochemistry. 43: 13063-13071. PMID 15476400 DOI: 10.1021/Bi0489098  1
2004 Gautschi JT, Whitman S, Holman TR, Crews P. An analysis of phakellin and oroidin structures stimulated by further study of an Agelas sponge Journal of Natural Products. 67: 1256-1261. PMID 15332838 DOI: 10.1021/Np0340495  1
2004 Segraves EN, Shah RR, Segraves NL, Johnson TA, Whitman S, Sui JK, Kenyon VA, Cichewicz RH, Crews P, Holman TR. Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. Journal of Medicinal Chemistry. 47: 4060-5. PMID 15267244 DOI: 10.1021/Jm049872S  1
2004 Gutierrez-Lugo MT, Deschamps JD, Holman TR, Suarez E, Timmermann BN. Lipoxygenase inhibition by anadanthoflavone, a new flavonoid from the aerial parts of Anadenanthera colubrina Planta Medica. 70: 263-265. PMID 15114507 DOI: 10.1055/S-2004-818920  1
2004 Ghosh K, Eroy-Reveles AA, Avila B, Holman TR, Olmstead MM, Mascharak PK. Reactions of NO with Mn(II) and Mn(III) Centers Coordinated to Carboxamido Nitrogen: Synthesis of a Manganese Nitrosyl with Photolabile NO Inorganic Chemistry. 43: 2988-2997. PMID 15106989 DOI: 10.1021/Ic030331N  1
2003 Schenk G, Neidig ML, Zhou J, Holman TR, Solomon EI. Spectroscopic characterization of soybean lipoxygenase-1 mutants: The role of second coordination sphere residues in the regulation of enzyme activity Biochemistry. 42: 7294-7302. PMID 12809485 DOI: 10.1021/Bi027380G  1
2003 Segraves EN, Holman TR. Kinetic investigations of the rate-limiting step in human 12- and 15-lipoxygenase Biochemistry. 42: 5236-5243. PMID 12731864 DOI: 10.1021/Bi0273462  1
2003 Ruddat VC, Whitman S, Holman TR, Bernasconi CF. Stopped-flow kinetic investigations of the activation of soybean lipoxygenase-1 and the influence of inhibitors on the allosteric site Biochemistry. 42: 4172-4178. PMID 12680771 DOI: 10.1021/Bi020698O  1
2003 Amagata T, Whitman S, Johnson TA, Stessman CC, Loo CP, Lobkovsky E, Clardy J, Crews P, Holman TR. Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases Journal of Natural Products. 66: 230-235. PMID 12608855 DOI: 10.1021/Np020462L  1
2003 Schenk G, Neidig ML, Zhou J, Holman TR, Solomon EI. Spectroscopic characterization of soybean lipoxygenase-1: The role of second coordination sphere residues in the regulation of enzyme activity Journal of Inorganic Biochemistry. 96: 225. DOI: 10.1016/S0162-0134(03)80762-6  1
2002 Whitman S, Gezginci M, Timmermann BN, Holman TR. Structure-activity relationship studies of nordihydroguaiaretic acid inhibitors toward soybean, 12-human, and 15-human lipoxygenase Journal of Medicinal Chemistry. 45: 2659-2661. PMID 12036375 DOI: 10.1021/Jm0201262  1
2001 Carroll J, Jonsson EN, Ebel R, Hartman MS, Holman TR, Crews P. Probing sponge-derived terpenoids for human 15-lipoxygenase inhibitors Journal of Organic Chemistry. 66: 6847-6851. PMID 11597201 DOI: 10.1021/Jo015784T  1
2001 Tomchick DR, Phan P, Cymborowski M, Minor W, Holman TR. Structural and functional characterization of second-coordination sphere mutants of soybean lipoxygenase-1 Biochemistry. 40: 7509-7517. PMID 11412104 DOI: 10.1021/Bi002893D  1
2001 Mogul R, Holman TR. Inhibition studies of soybean and human 15-lipoxygenases with long-chain alkenyl sulfate substrates Biochemistry. 40: 4391-4397. PMID 11284695 DOI: 10.1021/Bi002581A  1
2000 Mogul R, Johansen E, Holman TR. Oleyl sulfate reveals allosteric inhibition of soybean lipoxygenase-1 and human 15-lipoxygenase Biochemistry. 39: 4801-4807. PMID 10769137 DOI: 10.1021/Bi992805T  1
2000 Whitwam RE, Ahlert J, Holman TR, Ruppen M, Thorson JS. The gene calC encodes for a non-heme iron metalloprotein responsible for calicheamicin self-resistance in Micromonospora [9] Journal of the American Chemical Society. 122: 1556-1557. DOI: 10.1021/Ja993612W  1
1999 Lewis ER, Johansen E, Holman TR. Large competitive kinetic isotope effects in human 15-lipoxygenase catalysis measured by a novel HPLC method [9] Journal of the American Chemical Society. 121: 1395-1396. DOI: 10.1021/Ja983083G  1
1998 Holman TR, Zhou J, Solomon EI. Spectroscopic and functional characterization of a ligand coordination mutant of soybean lipoxygenase-1: First coordination sphere analogue of human 15-lipoxygenase Journal of the American Chemical Society. 120: 12564-12572. DOI: 10.1021/Ja982844C  1
1995 Holman TR, Wang Z, Hendrich MP, Que L. Structural and spectroscopic properties of antiferromagnetically coupled FeIIIMnII and FeIIMnII complexes Inorganic Chemistry. 34: 134-139. DOI: 10.1021/Ic00105A024  1
1994 Holman TR, Wu Z, Wanner BL, Walsh CT. Identification of the DNA-binding site for the phosphorylated VanR protein required for vancomycin resistance in Enterococcus faecium. Biochemistry. 33: 4625-31. PMID 8161518 DOI: 10.1021/Bi00181A024  1
1993 Wright GD, Holman TR, Walsh CT. Purification and characterization of VanR and the cytosolic domain of VanS: a two-component regulatory system required for vancomycin resistance in Enterococcus faecium BM4147. Biochemistry. 32: 5057-63. PMID 8494882 DOI: 10.1021/Bi00070A013  1
1992 Holman TR, Hendrich MP, Que L. EPR studies of a dinickel complex in its II,II and II,III oxidation states Inorganic Chemistry. 31: 937-939.  1
1991 Juarez-Garcia C, Hendrich MP, Holman TR, Que L, Münck E. Combined Mössbauer and EPR studies of the S = 3 state of an exchange-coupled FeIIICuII complex: Test for quantitative EPR analysis of integer spin systems Journal of the American Chemical Society. 113: 518-525.  1
1990 Holman TR, Juarez-Garcia C, Hendrich MP, Que L, Münck E. Models for iron-oxo proteins. Mössbauer and EPR study of an antiferromagnetically coupled FeIIINiII complex Journal of the American Chemical Society. 112: 7611-7618. DOI: 10.1021/Ja00177A024  1
1990 Borovik AS, Hendrich MP, Holman TR, Münck E, Papaefthymiou V, Que L. Models for diferrous forms of iron-oxo proteins. Structure and properties of [Fe2BPMP(O2CR)2]BPh4 complexes Journal of the American Chemical Society. 112: 6031-6038. DOI: 10.1021/Ja00172A019  1
1990 Holman TR, Andersen KA, Anderson OP, Hendrich MP, Juarez-Garcia C, Münck E, Que L. Correlations between magnetism and structure in dinuclear CuIIFeIII complexes with integer spin EPR signals Angewandte Chemie (International Edition in English). 29: 921-923. DOI: 10.1002/Anie.199009211  1
1987 Albizati KF, Holman T, Faulkner DJ, Glaser KB, Jacobs RS. Luffariellolide, an anti-inflammatory sesterterpene from the marine sponge Luffariella sp. Experientia. 43: 949-950. DOI: 10.1007/Bf01951682  1
1972 Briggs PF, Rouzer DL, Hamberg RL, Holman TR. Seven scales for the Minnesota-Briggs History Record with reference group data. Journal of Clinical Psychology. 28: 431-48. PMID 4404166  0.01
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