R. Scott Lokey - Publications

Chemistry & Biochemistry University of California, Santa Cruz, Santa Cruz, CA, United States 
drug discovery

23 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 van Hoorebeke C, Yang K, Mussetter SJ, Koch G, Rutz N, Lokey RS, Crews P, Holman TR. Reevaluation of a Bicyclic Pyrazoline as a Selective 15-Lipoxygenase V-Type Activator Possessing Fatty Acid Specificity. Acs Omega. 7: 43169-43179. PMID 36467910 DOI: 10.1021/acsomega.2c05877  0.651
2022 Taechalertpaisarn J, Ono S, Okada O, Johnstone TC, Lokey RS. A New Amino Acid for Improving Permeability and Solubility in Macrocyclic Peptides through Side Chain-to-Backbone Hydrogen Bonding. Journal of Medicinal Chemistry. PMID 35275623 DOI: 10.1021/acs.jmedchem.2c00010  0.304
2021 Klein VG, Bray WM, Wang HY, Edmondson Q, Schwochert J, Ono S, Naylor MR, Turmon AC, Faris JH, Okada O, Taunton J, Lokey RS. Identifying the Cellular Target of Cordyheptapeptide A and Synthetic Derivatives. Acs Chemical Biology. PMID 34251165 DOI: 10.1021/acschembio.1c00094  0.576
2020 Kelly CN, Townsend CE, Jain AN, Naylor MR, Pye CR, Schwochert J, Lokey RS. Geometrically Diverse Lariat Peptide Scaffolds Reveal an Untapped Chemical Space of High Membrane Permeability. Journal of the American Chemical Society. PMID 33381960 DOI: 10.1021/jacs.0c06115  0.322
2018 Nguyen QNN, Schwochert J, Tantillo DJ, Lokey RS. Using H and C NMR chemical shifts to determine cyclic peptide conformations: a combined molecular dynamics and quantum mechanics approach. Physical Chemistry Chemical Physics : Pccp. PMID 29744489 DOI: 10.1039/C8Cp01616J  0.308
2018 Townsend C, Furukawa A, Schwochert J, Pye CR, Edmondson Q, Lokey RS. CycLS: Accurate, whole-library sequencing of cyclic peptides using tandem mass spectrometry. Bioorganic & Medicinal Chemistry. PMID 29459147 DOI: 10.1016/j.bmc.2018.01.027  0.381
2017 Boehm M, Beaumont K, Jones RM, Kalgutkar AS, Zhang L, Atkinson K, Bai G, Brown JA, Eng H, Goetz GH, Holder BR, Khunte B, Lazzaro S, Limberakis C, Ryu S, ... ... Lokey RS, et al. Discovery of potent and orally bioavailable macrocyclic peptide-peptoid hybrid CXCR7 modulators. Journal of Medicinal Chemistry. PMID 29045152 DOI: 10.1021/Acs.Jmedchem.7B01028  0.627
2017 Naylor MR, Bockus AT, Blanco MJ, Lokey RS. Cyclic peptide natural products chart the frontier of oral bioavailability in the pursuit of undruggable targets. Current Opinion in Chemical Biology. 38: 141-147. PMID 28570865 DOI: 10.1016/j.cbpa.2017.04.012  0.336
2015 Schwochert J, Turner R, Thang M, Berkeley RF, Ponkey AR, Rodriguez KM, Leung SS, Khunte B, Goetz G, Limberakis C, Kalgutkar AS, Eng H, Shapiro MJ, Mathiowetz AM, Price DA, ... ... Lokey RS, et al. Peptide to Peptoid Substitutions Increase Cell Permeability in Cyclic Hexapeptides. Organic Letters. 17: 2928-31. PMID 26046483 DOI: 10.1021/Acs.Orglett.5B01162  0.569
2015 Bockus AT, Lexa KW, Pye CR, Kalgutkar AS, Gardner JW, Hund KC, Hewitt WM, Schwochert JA, Glassey E, Price DA, Mathiowetz AM, Liras S, Jacobson MP, Lokey RS. Probing the Physicochemical Boundaries of Cell Permeability and Oral Bioavailability in Lipophilic Macrocycles Inspired by Natural Products. Journal of Medicinal Chemistry. 58: 4581-9. PMID 25950816 DOI: 10.1021/Acs.Jmedchem.5B00128  0.339
2015 Hewitt WM, Leung SS, Pye CR, Ponkey AR, Bednarek M, Jacobson MP, Lokey RS. Cell-permeable cyclic peptides from synthetic libraries inspired by natural products. Journal of the American Chemical Society. 137: 715-21. PMID 25517352 DOI: 10.1021/Ja508766B  0.333
2014 Schwochert J, Pye C, Ahlbach C, Abdollahian Y, Farley K, Khunte B, Limberakis C, Kalgutkar AS, Eng H, Shapiro MJ, Mathiowetz AM, Price DA, Liras S, Lokey RS. Revisiting N-to-O acyl shift for synthesis of natural product-like cyclic depsipeptides. Organic Letters. 16: 6088-91. PMID 25412436 DOI: 10.1021/ol503170b  0.316
2013 Turner RA, Hauksson NE, Gipe JH, Lokey RS. Selective, on-resin N-methylation of peptide N-trifluoroacetamides Organic Letters. 15: 5012-5015. PMID 24063667 DOI: 10.1021/ol402341u  0.569
2013 Bockus AT, McEwen CM, Lokey RS. Form and function in cyclic peptide natural products: a pharmacokinetic perspective. Current Topics in Medicinal Chemistry. 13: 821-36. PMID 23578026  0.351
2012 Rand AC, Leung SS, Eng H, Rotter CJ, Sharma R, Kalgutkar AS, Zhang Y, Varma MV, Farley KA, Khunte B, Limberakis C, Price DA, Liras S, Mathiowetz AM, Jacobson MP, ... Lokey RS, et al. Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance(). Medchemcomm. 3: 1282-1289. PMID 23133740 DOI: 10.1039/C2Md20203D  0.315
2011 White TR, Renzelman CM, Rand AC, Rezai T, McEwen CM, Gelev VM, Turner RA, Linington RG, Leung SS, Kalgutkar AS, Bauman JN, Zhang Y, Liras S, Price DA, Mathiowetz AM, ... ... Lokey RS, et al. On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds. Nature Chemical Biology. 7: 810-7. PMID 21946276 DOI: 10.1038/Nchembio.664  0.556
2010 Turner RA, Weber RJ, Lokey RS. Direct conversion of resin-bound peptides to C-terminal esters Organic Letters. 12: 1852-1855. PMID 20329782 DOI: 10.1021/ol100471k  0.57
2007 Turner RA, Oliver AG, Lokey RS. Click chemistry as a macrocyclization tool in the solid-phase synthesis of small cyclic peptides. Organic Letters. 9: 5011-4. PMID 17956112 DOI: 10.1021/ol702228u  0.579
2005 Perlman ZE, Bock JE, Peterson JR, Lokey RS. Geometric diversity through permutation of backbone configuration in cyclic peptide libraries Bioorganic and Medicinal Chemistry Letters. 15: 5329-5334. PMID 16213707 DOI: 10.1016/J.Bmcl.2005.07.089  0.746
2001 Peterson JR, Lokey RS, Mitchison TJ, Kirschner MW. A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions. Proceedings of the National Academy of Sciences of the United States of America. 98: 10624-9. PMID 11553809 DOI: 10.1073/Pnas.201393198  0.601
2001 Guelev VM, Cubberley MS, Murr MM, Lokey RS, Iverson BL. Design, synthesis, and characterization of polyintercalating ligands. Methods in Enzymology. 340: 556-70. PMID 11494870 DOI: 10.1016/S0076-6879(01)40442-3  0.606
2000 Guelev VM, Harting MT, Lokey RS, Iverson BL. Altered sequence specificity identified from a library of DNA-binding small molecules. Chemistry & Biology. 7: 1-8. PMID 10662682 DOI: 10.1016/S1074-5521(00)00007-X  0.755
1997 Lokey RS, Kwok Y, Guelev V, Pursell CJ, Hurley LH, Iverson BL. A new class of polyintercalating molecules Journal of the American Chemical Society. 119: 7202-7210. DOI: 10.1021/Ja9706108  0.756
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