R. Scott Lokey - Publications

Chemistry & Biochemistry University of California, Santa Cruz, Santa Cruz, CA, United States 
drug discovery

41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Suresh S, Schlecht U, Xu W, Bray W, Miranda M, Davis RW, Nislow C, Giaever G, Lokey RS, St Onge RP. Systematic Mapping of Chemical-Genetic Interactions in Saccharomyces cerevisiae. Cold Spring Harbor Protocols. 2016: pdb.top077701. PMID 27587783 DOI: 10.1101/Pdb.Top077701  0.92
2016 Bray W, Lokey RS. A High-Throughput Yeast Halo Assay for Bioactive Compounds. Cold Spring Harbor Protocols. 2016: pdb.prot088047. PMID 27587777 DOI: 10.1101/pdb.prot088047  0.92
2016 Schwochert J, Lao Y, Pye CR, Naylor MR, Desai PV, Gonzalez Valcarcel IC, Barrett JA, Sawada G, Blanco MJ, Lokey RS. Stereochemistry Balances Cell Permeability and Solubility in the Naturally Derived Phepropeptin Cyclic Peptides. Acs Medicinal Chemistry Letters. 7: 757-61. PMID 27563399 DOI: 10.1021/acsmedchemlett.6b00100  0.92
2016 Pye CR, Bray WM, Brown ER, Burke JR, Lokey RS, Rubin SM. A Strategy for Direct Chemical Activation of the Retinoblastoma Protein. Acs Chemical Biology. PMID 26845289 DOI: 10.1021/Acschembio.6B00011  0.92
2015 Bockus AT, Schwochert JA, Pye CR, Townsend CE, Sok V, Bednarek MA, Lokey RS. Going Out on a Limb: Delineating The Effects of β-Branching, N-Methylation, and Side Chain Size on the Passive Permeability, Solubility, and Flexibility of Sanguinamide A Analogues. Journal of Medicinal Chemistry. 58: 7409-18. PMID 26308180 DOI: 10.1021/acs.jmedchem.5b00919  0.92
2015 Ochoa JL, Bray WM, Lokey RS, Linington RG. Phenotype-Guided Natural Products Discovery Using Cytological Profiling. Journal of Natural Products. 78: 2242-8. PMID 26292657 DOI: 10.1021/Acs.Jnatprod.5B00455  0.92
2015 Ahlbach CL, Lexa KW, Bockus AT, Chen V, Crews P, Jacobson MP, Lokey RS. Beyond cyclosporine A: conformation-dependent passive membrane permeabilities of cyclic peptide natural products. Future Medicinal Chemistry. 1-10. PMID 26067057 DOI: 10.4155/Fmc.15.78  0.92
2015 Schwochert J, Turner R, Thang M, Berkeley RF, Ponkey AR, Rodriguez KM, Leung SS, Khunte B, Goetz G, Limberakis C, Kalgutkar AS, Eng H, Shapiro MJ, Mathiowetz AM, Price DA, ... ... Lokey RS, et al. Peptide to Peptoid Substitutions Increase Cell Permeability in Cyclic Hexapeptides. Organic Letters. 17: 2928-31. PMID 26046483 DOI: 10.1021/Acs.Orglett.5B01162  0.92
2015 Bockus AT, Lexa KW, Pye CR, Kalgutkar AS, Gardner JW, Hund KC, Hewitt WM, Schwochert JA, Glassey E, Price DA, Mathiowetz AM, Liras S, Jacobson MP, Lokey RS. Probing the Physicochemical Boundaries of Cell Permeability and Oral Bioavailability in Lipophilic Macrocycles Inspired by Natural Products. Journal of Medicinal Chemistry. 58: 4581-9. PMID 25950816 DOI: 10.1021/Acs.Jmedchem.5B00128  0.92
2015 Theodore CM, Lorig-Roach N, Still PC, Johnson TA, Draškovi? M, Schwochert JA, Naphen CN, Crews MS, Barker SA, Valeriote FA, Lokey RS, Crews P. Biosynthetic products from a nearshore-derived gram-negative bacterium enable reassessment of the kailuin depsipeptides. Journal of Natural Products. 78: 441-52. PMID 25699470 DOI: 10.1021/Np500840N  0.92
2015 Hewitt WM, Leung SS, Pye CR, Ponkey AR, Bednarek M, Jacobson MP, Lokey RS. Cell-permeable cyclic peptides from synthetic libraries inspired by natural products. Journal of the American Chemical Society. 137: 715-21. PMID 25517352 DOI: 10.1021/Ja508766B  0.92
2014 Schwochert J, Pye C, Ahlbach C, Abdollahian Y, Farley K, Khunte B, Limberakis C, Kalgutkar AS, Eng H, Shapiro MJ, Mathiowetz AM, Price DA, Liras S, Lokey RS. Revisiting N-to-O acyl shift for synthesis of natural product-like cyclic depsipeptides. Organic Letters. 16: 6088-91. PMID 25412436 DOI: 10.1021/ol503170b  0.92
2013 Turner RA, Hauksson NE, Gipe JH, Lokey RS. Selective, on-resin N-methylation of peptide N-trifluoroacetamides Organic Letters. 15: 5012-5015. PMID 24063667 DOI: 10.1021/ol402341u  0.92
2013 Woehrmann MH, Bray WM, Durbin JK, Nisam SC, Michael AK, Glassey E, Stuart JM, Lokey RS. Large-scale cytological profiling for functional analysis of bioactive compounds. Molecular Biosystems. 9: 2604-17. PMID 24056581 DOI: 10.1039/C3Mb70245F  0.92
2013 Effenberger KA, Perriman RJ, Bray WM, Lokey RS, Ares M, Jurica MS. A high-throughput splicing assay identifies new classes of inhibitors of human and yeast spliceosomes Journal of Biomolecular Screening. 18: 1110-1120. PMID 23771823 DOI: 10.1177/1087057113493117  0.92
2013 Schulze CJ, Bray WM, Woerhmann MH, Stuart J, Lokey RS, Linington RG. "Function-first" lead discovery: mode of action profiling of natural product libraries using image-based screening. Chemistry & Biology. 20: 285-95. PMID 23438757 DOI: 10.1016/J.Chembiol.2012.12.007  0.92
2012 Rand AC, Leung SS, Eng H, Rotter CJ, Sharma R, Kalgutkar AS, Zhang Y, Varma MV, Farley KA, Khunte B, Limberakis C, Price DA, Liras S, Mathiowetz AM, Jacobson MP, ... Lokey RS, et al. Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance(). Medchemcomm. 3: 1282-1289. PMID 23133740 DOI: 10.1039/C2Md20203D  0.92
2012 Serbus LR, Landmann F, Bray WM, White PM, Ruybal J, Lokey RS, Debec A, Sullivan W. A cell-based screen reveals that the albendazole metabolite, albendazole sulfone, targets Wolbachia. Plos Pathogens. 8: e1002922. PMID 23028321 DOI: 10.1371/journal.ppat.1002922  0.92
2012 Zuckerman NB, Myers AS, Quan TK, Bray WM, Lokey RS, Hartzog GA, Konopelski JP. Structural Determination of NSC 670224, Synthesis of Analogues and Biological Evaluation Chemmedchem. 7: 761-765. PMID 22378491 DOI: 10.1002/Cmdc.201200038  0.92
2011 Johnson TA, Sohn J, Inman WD, Estee SA, Loveridge ST, Vervoort HC, Tenney K, Liu J, Ang KK, Ratnam J, Bray WM, Gassner NC, Shen YY, Lokey RS, McKerrow JH, et al. Natural product libraries to accelerate the high-throughput discovery of therapeutic leads. Journal of Natural Products. 74: 2545-55. PMID 22129061 DOI: 10.1021/Np200673B  0.92
2011 White TR, Renzelman CM, Rand AC, Rezai T, McEwen CM, Gelev VM, Turner RA, Linington RG, Leung SS, Kalgutkar AS, Bauman JN, Zhang Y, Liras S, Price DA, Mathiowetz AM, ... ... Lokey RS, et al. On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds. Nature Chemical Biology. 7: 810-7. PMID 21946276 DOI: 10.1038/Nchembio.664  0.92
2011 Tamble CM, St. Onge RP, Giaever G, Nislow C, Williams AG, Stuart JM, Lokey RS. The synthetic genetic interaction network reveals small molecules that target specific pathways in Sacchromyces cerevisiae Molecular Biosystems. 7: 2019-2030. PMID 21487606 DOI: 10.1039/C0Mb00298D  0.92
2011 Peach KC, Bray WM, Shikuma NJ, Gassner NC, Lokey RS, Yildiz FH, Linington RG. An image-based 384-well high-throughput screening method for the discovery of biofilm inhibitors in Vibrio cholerae. Molecular Biosystems. 7: 1176-84. PMID 21246108 DOI: 10.1039/C0Mb00276C  0.92
2011 Watts KR, Morinaka BI, Amagata T, Robinson SJ, Tenney K, Bray WM, Gassner NC, Lokey RS, Media J, Valeriote FA, Crews P. Biostructural features of additional jasplakinolide (jaspamide) analogues. Journal of Natural Products. 74: 341-51. PMID 21241058 DOI: 10.1021/Np100721G  0.92
2010 Kapitzky L, Beltrao P, Berens TJ, Gassner N, Zhou C, Wüster A, Wu J, Babu MM, Elledge SJ, Toczyski D, Lokey RS, Krogan NJ. Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action. Molecular Systems Biology. 6: 451. PMID 21179023 DOI: 10.1038/Msb.2010.107  0.92
2010 Turner RA, Weber RJ, Lokey RS. Direct conversion of resin-bound peptides to C-terminal esters Organic Letters. 12: 1852-1855. PMID 20329782 DOI: 10.1021/ol100471k  0.92
2007 Turner RA, Oliver AG, Lokey RS. Click chemistry as a macrocyclization tool in the solid-phase synthesis of small cyclic peptides. Organic Letters. 9: 5011-4. PMID 17956112 DOI: 10.1021/ol702228u  0.92
2007 Boot CM, Gassner NC, Compton JE, Tenney K, Tamble CM, Lokey RS, Holman TR, Crews P. Pinpointing pseurotins from a marine-derived Aspergillus as tools for chemical genetics using a synthetic lethality yeast screen Journal of Natural Products. 70: 1672-1675. PMID 17929896 DOI: 10.1021/Np070307C  0.92
2007 Schuresko LA, Lokey RS. A practical solid-phase synthesis of Glu7-phalloidin and entry into fluorescent F-actin-binding reagents Angewandte Chemie - International Edition. 46: 3547-3549. PMID 17385816 DOI: 10.1002/Anie.200700017  0.92
2007 Gassner NC, Tamble CM, Bock JE, Cotton N, White KN, Tenney K, St. Onge RP, Proctor MJ, Giaever G, Nislow C, Davis RW, Crews P, Holman TR, Lokey RS. Accelerating the discovery of biologically active small molecules using a high-throughput yeast halo assay Journal of Natural Products. 70: 383-390. PMID 17291044 DOI: 10.1021/Np060555T  0.92
2007 Ralifo P, Sanchez L, Gassner NC, Tenney K, Lokey RS, Holman TR, Valeriote FA, Crews P. Pyrroloacridine alkaloids from Plakortis quasiamphiaster: Structures and bioactivity Journal of Natural Products. 70: 95-99. PMID 17253856 DOI: 10.1021/Np060585W  0.92
2007 Combs DJ, Lokey RS. Extended peptoids: a new class of oligomers based on aromatic building blocks Tetrahedron Letters. 48: 2679-2682. DOI: 10.1016/j.tetlet.2007.02.075  0.92
2006 Rezai T, Bock JE, Zhou MV, Kalyanaraman C, Lokey RS, Jacobson MP. Conformational flexibility, internal hydrogen bonding, and passive membrane permeability: Successful in silico prediction of the relative permeabilities of cyclic peptides Journal of the American Chemical Society. 128: 14073-14080. PMID 17061890 DOI: 10.1021/Ja063076P  0.92
2006 Rezai T, Yu B, Millhauser GL, Jacobson MP, Lokey RS. Testing the conformational hypothesis of passive membrane permeability using synthetic cyclic peptide diastereomers Journal of the American Chemical Society. 128: 2510-2511. PMID 16492015 DOI: 10.1021/Ja0563455  0.92
2005 Perlman ZE, Bock JE, Peterson JR, Lokey RS. Geometric diversity through permutation of backbone configuration in cyclic peptide libraries Bioorganic and Medicinal Chemistry Letters. 15: 5329-5334. PMID 16213707 DOI: 10.1016/J.Bmcl.2005.07.089  0.92
2005 Simon RA, Schuresko L, Dendukuri N, Goers E, Murphy B, Lokey RS. One-bead-one-compound library of end-capped dipeptides and deconvolution by microflow NMR Journal of Combinatorial Chemistry. 7: 697-702. DOI: 10.1021/cc0500194  0.92
2003 Lokey RS. Forward chemical genetics: Progress and obstacles on the path to a new pharmacopoeia Current Opinion in Chemical Biology. 7: 91-96. PMID 12547432 DOI: 10.1016/S1367-5931(02)00002-9  0.92
2001 Peterson JR, Lokey RS, Mitchison TJ, Kirschner MW. A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions. Proceedings of the National Academy of Sciences of the United States of America. 98: 10624-9. PMID 11553809 DOI: 10.1073/Pnas.201393198  0.92
2001 Guelev VM, Cubberley MS, Murr MM, Lokey RS, Iverson BL. Design, synthesis, and characterization of polyintercalating ligands. Methods in Enzymology. 340: 556-70. PMID 11494870 DOI: 10.1016/S0076-6879(01)40442-3  0.92
2000 Guelev VM, Harting MT, Lokey RS, Iverson BL. Altered sequence specificity identified from a library of DNA-binding small molecules. Chemistry & Biology. 7: 1-8. PMID 10662682 DOI: 10.1016/S1074-5521(00)00007-X  0.92
1997 Lokey RS, Kwok Y, Guelev V, Pursell CJ, Hurley LH, Iverson BL. A new class of polyintercalating molecules Journal of the American Chemical Society. 119: 7202-7210. DOI: 10.1021/Ja9706108  0.92
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