| Year |
Citation |
Score |
| 2024 |
Koch G, Engstrom A, Taechalertpaisarn J, Faris J, Ono S, Naylor MR, Lokey RS. Chromatographic Determination of Permeability-Relevant Lipophilicity Facilitates Rapid Analysis of Macrocyclic Peptide Scaffolds. Journal of Medicinal Chemistry. PMID 39453819 DOI: 10.1021/acs.jmedchem.4c01956 |
0.735 |
|
| 2024 |
Faris JH, Adaligil E, Popovych N, Ono S, Takahashi M, Nguyen H, Plise E, Taechalertpaisarn J, Lee HW, Koehler MFT, Cunningham CN, Lokey RS. Membrane Permeability in a Large Macrocyclic Peptide Driven by a Saddle-Shaped Conformation. Journal of the American Chemical Society. PMID 38330910 DOI: 10.1021/jacs.3c10949 |
0.411 |
|
| 2023 |
Zhang P, Koch G, Zhang Y, Yang K, Lokey RS. DNA-Compatible Conditions for the Formation of -Methyl Peptide Bonds. Acs Omega. 8: 23477-23483. PMID 37426286 DOI: 10.1021/acsomega.3c00576 |
0.758 |
|
| 2022 |
van Hoorebeke C, Yang K, Mussetter SJ, Koch G, Rutz N, Lokey RS, Crews P, Holman TR. Reevaluation of a Bicyclic Pyrazoline as a Selective 15-Lipoxygenase V-Type Activator Possessing Fatty Acid Specificity. Acs Omega. 7: 43169-43179. PMID 36467910 DOI: 10.1021/acsomega.2c05877 |
0.705 |
|
| 2022 |
Taechalertpaisarn J, Ono S, Okada O, Johnstone TC, Lokey RS. A New Amino Acid for Improving Permeability and Solubility in Macrocyclic Peptides through Side Chain-to-Backbone Hydrogen Bonding. Journal of Medicinal Chemistry. PMID 35275623 DOI: 10.1021/acs.jmedchem.2c00010 |
0.363 |
|
| 2021 |
Klein VG, Bray WM, Wang HY, Edmondson Q, Schwochert J, Ono S, Naylor MR, Turmon AC, Faris JH, Okada O, Taunton J, Lokey RS. Identifying the Cellular Target of Cordyheptapeptide A and Synthetic Derivatives. Acs Chemical Biology. PMID 34251165 DOI: 10.1021/acschembio.1c00094 |
0.601 |
|
| 2020 |
Kelly CN, Townsend CE, Jain AN, Naylor MR, Pye CR, Schwochert J, Lokey RS. Geometrically Diverse Lariat Peptide Scaffolds Reveal an Untapped Chemical Space of High Membrane Permeability. Journal of the American Chemical Society. PMID 33381960 DOI: 10.1021/jacs.0c06115 |
0.367 |
|
| 2020 |
Furukawa A, Schwochert J, Pye CR, Asano D, Edmondson QD, Turmon A, Klein V, Ono S, Okada O, Lokey RS. Drug-like properties in macrocycles above MW 1000: Backbone rigidity vs. side-chain lipophilicity. Angewandte Chemie (International Ed. in English). PMID 32789999 DOI: 10.1002/anie.202004550 |
0.319 |
|
| 2018 |
Nguyen QNN, Schwochert J, Tantillo DJ, Lokey RS. Using H and C NMR chemical shifts to determine cyclic peptide conformations: a combined molecular dynamics and quantum mechanics approach. Physical Chemistry Chemical Physics : Pccp. PMID 29744489 DOI: 10.1039/C8Cp01616J |
0.333 |
|
| 2018 |
Townsend C, Furukawa A, Schwochert J, Pye CR, Edmondson Q, Lokey RS. CycLS: Accurate, whole-library sequencing of cyclic peptides using tandem mass spectrometry. Bioorganic & Medicinal Chemistry. PMID 29459147 DOI: 10.1016/j.bmc.2018.01.027 |
0.416 |
|
| 2017 |
Boehm M, Beaumont K, Jones RM, Kalgutkar AS, Zhang L, Atkinson K, Bai G, Brown JA, Eng H, Goetz GH, Holder BR, Khunte B, Lazzaro S, Limberakis C, Ryu S, ... ... Lokey RS, et al. Discovery of potent and orally bioavailable macrocyclic peptide-peptoid hybrid CXCR7 modulators. Journal of Medicinal Chemistry. PMID 29045152 DOI: 10.1021/Acs.Jmedchem.7B01028 |
0.645 |
|
| 2017 |
Naylor MR, Bockus AT, Blanco MJ, Lokey RS. Cyclic peptide natural products chart the frontier of oral bioavailability in the pursuit of undruggable targets. Current Opinion in Chemical Biology. 38: 141-147. PMID 28570865 DOI: 10.1016/j.cbpa.2017.04.012 |
0.366 |
|
| 2016 |
Furukawa A, Townsend CE, Schwochert JA, Pye CR, Bednarek MA, Lokey RS. Passive membrane permeability in cyclic peptomer scaffolds is robust to extensive variation in side chain functionality and backbone geometry. Journal of Medicinal Chemistry. PMID 27690434 DOI: 10.1021/acs.jmedchem.6b01246 |
0.319 |
|
| 2016 |
Schwochert J, Lao Y, Pye CR, Naylor MR, Desai PV, Gonzalez Valcarcel IC, Barrett JA, Sawada G, Blanco MJ, Lokey RS. Stereochemistry Balances Cell Permeability and Solubility in the Naturally Derived Phepropeptin Cyclic Peptides. Acs Medicinal Chemistry Letters. 7: 757-61. PMID 27563399 DOI: 10.1021/acsmedchemlett.6b00100 |
0.325 |
|
| 2015 |
Ahlbach CL, Lexa KW, Bockus AT, Chen V, Crews P, Jacobson MP, Lokey RS. Beyond cyclosporine A: conformation-dependent passive membrane permeabilities of cyclic peptide natural products. Future Medicinal Chemistry. 1-10. PMID 26067057 DOI: 10.4155/Fmc.15.78 |
0.335 |
|
| 2015 |
Schwochert J, Turner R, Thang M, Berkeley RF, Ponkey AR, Rodriguez KM, Leung SS, Khunte B, Goetz G, Limberakis C, Kalgutkar AS, Eng H, Shapiro MJ, Mathiowetz AM, Price DA, ... ... Lokey RS, et al. Peptide to Peptoid Substitutions Increase Cell Permeability in Cyclic Hexapeptides. Organic Letters. 17: 2928-31. PMID 26046483 DOI: 10.1021/Acs.Orglett.5B01162 |
0.604 |
|
| 2015 |
Bockus AT, Lexa KW, Pye CR, Kalgutkar AS, Gardner JW, Hund KC, Hewitt WM, Schwochert JA, Glassey E, Price DA, Mathiowetz AM, Liras S, Jacobson MP, Lokey RS. Probing the Physicochemical Boundaries of Cell Permeability and Oral Bioavailability in Lipophilic Macrocycles Inspired by Natural Products. Journal of Medicinal Chemistry. 58: 4581-9. PMID 25950816 DOI: 10.1021/Acs.Jmedchem.5B00128 |
0.363 |
|
| 2015 |
Hewitt WM, Leung SS, Pye CR, Ponkey AR, Bednarek M, Jacobson MP, Lokey RS. Cell-permeable cyclic peptides from synthetic libraries inspired by natural products. Journal of the American Chemical Society. 137: 715-21. PMID 25517352 DOI: 10.1021/Ja508766B |
0.377 |
|
| 2014 |
Schwochert J, Pye C, Ahlbach C, Abdollahian Y, Farley K, Khunte B, Limberakis C, Kalgutkar AS, Eng H, Shapiro MJ, Mathiowetz AM, Price DA, Liras S, Lokey RS. Revisiting N-to-O acyl shift for synthesis of natural product-like cyclic depsipeptides. Organic Letters. 16: 6088-91. PMID 25412436 DOI: 10.1021/ol503170b |
0.349 |
|
| 2013 |
Turner RA, Hauksson NE, Gipe JH, Lokey RS. Selective, on-resin N-methylation of peptide N-trifluoroacetamides Organic Letters. 15: 5012-5015. PMID 24063667 DOI: 10.1021/ol402341u |
0.608 |
|
| 2013 |
Bockus AT, McEwen CM, Lokey RS. Form and function in cyclic peptide natural products: a pharmacokinetic perspective. Current Topics in Medicinal Chemistry. 13: 821-36. PMID 23578026 |
0.384 |
|
| 2012 |
Rand AC, Leung SS, Eng H, Rotter CJ, Sharma R, Kalgutkar AS, Zhang Y, Varma MV, Farley KA, Khunte B, Limberakis C, Price DA, Liras S, Mathiowetz AM, Jacobson MP, ... Lokey RS, et al. Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance(). Medchemcomm. 3: 1282-1289. PMID 23133740 DOI: 10.1039/C2Md20203D |
0.35 |
|
| 2011 |
White TR, Renzelman CM, Rand AC, Rezai T, McEwen CM, Gelev VM, Turner RA, Linington RG, Leung SS, Kalgutkar AS, Bauman JN, Zhang Y, Liras S, Price DA, Mathiowetz AM, ... ... Lokey RS, et al. On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds. Nature Chemical Biology. 7: 810-7. PMID 21946276 DOI: 10.1038/Nchembio.664 |
0.596 |
|
| 2010 |
Turner RA, Weber RJ, Lokey RS. Direct conversion of resin-bound peptides to C-terminal esters Organic Letters. 12: 1852-1855. PMID 20329782 DOI: 10.1021/ol100471k |
0.598 |
|
| 2007 |
Turner RA, Oliver AG, Lokey RS. Click chemistry as a macrocyclization tool in the solid-phase synthesis of small cyclic peptides. Organic Letters. 9: 5011-4. PMID 17956112 DOI: 10.1021/ol702228u |
0.603 |
|
| 2005 |
Perlman ZE, Bock JE, Peterson JR, Lokey RS. Geometric diversity through permutation of backbone configuration in cyclic peptide libraries Bioorganic and Medicinal Chemistry Letters. 15: 5329-5334. PMID 16213707 DOI: 10.1016/J.Bmcl.2005.07.089 |
0.767 |
|
| 2001 |
Peterson JR, Lokey RS, Mitchison TJ, Kirschner MW. A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions. Proceedings of the National Academy of Sciences of the United States of America. 98: 10624-9. PMID 11553809 DOI: 10.1073/Pnas.201393198 |
0.605 |
|
| 2001 |
Guelev VM, Cubberley MS, Murr MM, Lokey RS, Iverson BL. Design, synthesis, and characterization of polyintercalating ligands. Methods in Enzymology. 340: 556-70. PMID 11494870 DOI: 10.1016/S0076-6879(01)40442-3 |
0.644 |
|
| 2000 |
Guelev VM, Harting MT, Lokey RS, Iverson BL. Altered sequence specificity identified from a library of DNA-binding small molecules. Chemistry & Biology. 7: 1-8. PMID 10662682 DOI: 10.1016/S1074-5521(00)00007-X |
0.77 |
|
| 1997 |
Lokey RS, Kwok Y, Guelev V, Pursell CJ, Hurley LH, Iverson BL. A new class of polyintercalating molecules Journal of the American Chemical Society. 119: 7202-7210. DOI: 10.1021/Ja9706108 |
0.774 |
|
| Low-probability matches (unlikely to be authored by this person) |
| 2015 |
Theodore CM, Lorig-Roach N, Still PC, Johnson TA, Draškovi? M, Schwochert JA, Naphen CN, Crews MS, Barker SA, Valeriote FA, Lokey RS, Crews P. Biosynthetic products from a nearshore-derived gram-negative bacterium enable reassessment of the kailuin depsipeptides. Journal of Natural Products. 78: 441-52. PMID 25699470 DOI: 10.1021/Np500840N |
0.296 |
|
| 2021 |
Klein VG, Bond AG, Craigon C, Lokey RS, Ciulli A. Amide-to-Ester Substitution as a Strategy for Optimizing PROTAC Permeability and Cellular Activity. Journal of Medicinal Chemistry. 64: 18082-18101. PMID 34881891 DOI: 10.1021/acs.jmedchem.1c01496 |
0.279 |
|
| 2020 |
Stadelmann T, Subramanian G, Menon S, Townsend CE, Lokey RS, Ebert MO, Riniker S. Connecting the conformational behavior of cyclic octadepsipeptides with their ionophoric property and membrane permeability. Organic & Biomolecular Chemistry. PMID 32902550 DOI: 10.1039/D0Ob01447H |
0.275 |
|
| 2017 |
Pye CR, Hewitt WM, Schwochert JA, Haddad TD, Townsend CE, Etienne L, Lao Y, Limberakis C, Furukawa A, Mathiowetz AM, Price DA, Liras S, Lokey RS. Non-Classical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules. Journal of Medicinal Chemistry. PMID 28059508 DOI: 10.1021/Acs.Jmedchem.6B01483 |
0.274 |
|
| 2016 |
Pye CR, Bray WM, Brown ER, Burke JR, Lokey RS, Rubin SM. A Strategy for Direct Chemical Activation of the Retinoblastoma Protein. Acs Chemical Biology. PMID 26845289 DOI: 10.1021/Acschembio.6B00011 |
0.271 |
|
| 2005 |
Simon RA, Schuresko L, Dendukuri N, Goers E, Murphy B, Lokey RS. One-bead-one-compound library of end-capped dipeptides and deconvolution by microflow NMR. Journal of Combinatorial Chemistry. 7: 697-702. PMID 16153064 DOI: 10.1021/Cc0500194 |
0.271 |
|
| 2011 |
Tamble CM, St. Onge RP, Giaever G, Nislow C, Williams AG, Stuart JM, Lokey RS. The synthetic genetic interaction network reveals small molecules that target specific pathways in Sacchromyces cerevisiae Molecular Biosystems. 7: 2019-2030. PMID 21487606 DOI: 10.1039/C0Mb00298D |
0.266 |
|
| 2015 |
Bockus AT, Schwochert JA, Pye CR, Townsend CE, Sok V, Bednarek MA, Lokey RS. Going Out on a Limb: Delineating The Effects of β-Branching, N-Methylation, and Side Chain Size on the Passive Permeability, Solubility, and Flexibility of Sanguinamide A Analogues. Journal of Medicinal Chemistry. 58: 7409-18. PMID 26308180 DOI: 10.1021/acs.jmedchem.5b00919 |
0.26 |
|
| 2007 |
Combs DJ, Lokey RS. Extended peptoids: a new class of oligomers based on aromatic building blocks. Tetrahedron Letters. 48: 2679-2682. PMID 18398447 DOI: 10.1016/j.tetlet.2007.02.075 |
0.251 |
|
| 2006 |
Rezai T, Bock JE, Zhou MV, Kalyanaraman C, Lokey RS, Jacobson MP. Conformational flexibility, internal hydrogen bonding, and passive membrane permeability: Successful in silico prediction of the relative permeabilities of cyclic peptides Journal of the American Chemical Society. 128: 14073-14080. PMID 17061890 DOI: 10.1021/Ja063076P |
0.247 |
|
| 2003 |
Lokey RS. Forward chemical genetics: Progress and obstacles on the path to a new pharmacopoeia Current Opinion in Chemical Biology. 7: 91-96. PMID 12547432 DOI: 10.1016/S1367-5931(02)00002-9 |
0.242 |
|
| 2019 |
Ono S, Naylor MR, Townsend CE, Okumura C, Okada O, Lokey RS. Conformation and Permeability: Cyclic Hexapeptide Diastereomers. Journal of Chemical Information and Modeling. PMID 31042375 DOI: 10.1021/acs.jcim.9b00217 |
0.24 |
|
| 2018 |
Naylor MR, Ly AM, Handford MJ, Ramos DP, Pye CR, Furukawa A, Klein V, Noland RP, Edmondson Q, Turmon AC, Hewitt WM, Schwochert J, Townsend CE, Kelly CN, Blanco MJ, ... Lokey RS, et al. Lipophilic Permeability Efficiency (LPE) reconciles the opposing roles of lipophilicity in membrane permeability and aqueous solubility. Journal of Medicinal Chemistry. PMID 30395703 DOI: 10.1021/Acs.Jmedchem.8B01259 |
0.237 |
|
| 2013 |
Effenberger KA, Perriman RJ, Bray WM, Lokey RS, Ares M, Jurica MS. A high-throughput splicing assay identifies new classes of inhibitors of human and yeast spliceosomes Journal of Biomolecular Screening. 18: 1110-1120. PMID 23771823 DOI: 10.1177/1087057113493117 |
0.236 |
|
| 2013 |
Woehrmann MH, Bray WM, Durbin JK, Nisam SC, Michael AK, Glassey E, Stuart JM, Lokey RS. Large-scale cytological profiling for functional analysis of bioactive compounds. Molecular Biosystems. 9: 2604-17. PMID 24056581 DOI: 10.1039/C3Mb70245F |
0.232 |
|
| 2011 |
Johnson TA, Sohn J, Inman WD, Estee SA, Loveridge ST, Vervoort HC, Tenney K, Liu J, Ang KK, Ratnam J, Bray WM, Gassner NC, Shen YY, Lokey RS, McKerrow JH, et al. Natural product libraries to accelerate the high-throughput discovery of therapeutic leads. Journal of Natural Products. 74: 2545-55. PMID 22129061 DOI: 10.1021/Np200673B |
0.228 |
|
| 2005 |
Simon RA, Schuresko L, Dendukuri N, Goers E, Murphy B, Lokey RS. One-bead-one-compound library of end-capped dipeptides and deconvolution by microflow NMR Journal of Combinatorial Chemistry. 7: 697-702. DOI: 10.1021/cc0500194 |
0.223 |
|
| 2012 |
Serbus LR, Landmann F, Bray WM, White PM, Ruybal J, Lokey RS, Debec A, Sullivan W. A cell-based screen reveals that the albendazole metabolite, albendazole sulfone, targets Wolbachia. Plos Pathogens. 8: e1002922. PMID 23028321 DOI: 10.1371/journal.ppat.1002922 |
0.217 |
|
| 2007 |
Boot CM, Gassner NC, Compton JE, Tenney K, Tamble CM, Lokey RS, Holman TR, Crews P. Pinpointing pseurotins from a marine-derived Aspergillus as tools for chemical genetics using a synthetic lethality yeast screen Journal of Natural Products. 70: 1672-1675. PMID 17929896 DOI: 10.1021/Np070307C |
0.216 |
|
| 2010 |
Kapitzky L, Beltrao P, Berens TJ, Gassner N, Zhou C, Wüster A, Wu J, Babu MM, Elledge SJ, Toczyski D, Lokey RS, Krogan NJ. Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action. Molecular Systems Biology. 6: 451. PMID 21179023 DOI: 10.1038/Msb.2010.107 |
0.214 |
|
| 2015 |
Ochoa JL, Bray WM, Lokey RS, Linington RG. Phenotype-Guided Natural Products Discovery Using Cytological Profiling. Journal of Natural Products. 78: 2242-8. PMID 26292657 DOI: 10.1021/Acs.Jnatprod.5B00455 |
0.213 |
|
| 2020 |
Foley AR, Roseman GP, Chan K, Smart A, Finn TS, Yang K, Lokey RS, Millhauser GL, Raskatov JA. Evidence for aggregation-independent, PrP-mediated Aβ cellular internalization. Proceedings of the National Academy of Sciences of the United States of America. PMID 33139554 DOI: 10.1073/pnas.2009238117 |
0.211 |
|
| 2013 |
Schulze CJ, Bray WM, Woerhmann MH, Stuart J, Lokey RS, Linington RG. "Function-first" lead discovery: mode of action profiling of natural product libraries using image-based screening. Chemistry & Biology. 20: 285-95. PMID 23438757 DOI: 10.1016/J.Chembiol.2012.12.007 |
0.207 |
|
| 2020 |
Shi Y, Bray W, Smith AJ, Zhou W, Calaoagan J, Lagisetti C, Sambucetti L, Crews P, Lokey RS, Webb TR. An exon skipping screen identifies antitumor drugs that are potent modulators of pre-mRNA splicing, suggesting new therapeutic applications. Plos One. 15: e0233672. PMID 32469945 DOI: 10.1371/Journal.Pone.0233672 |
0.206 |
|
| 2022 |
Hight SK, Clark TN, Kurita KL, McMillan EA, Bray W, Shaikh AF, Khadilkar A, Haeckl FPJ, Carnevale-Neto F, La S, Lohith A, Vaden RM, Lee J, Wei S, Lokey RS, et al. High-throughput functional annotation of natural products by integrated activity profiling. Proceedings of the National Academy of Sciences of the United States of America. 119: e2208458119. PMID 36449542 DOI: 10.1073/pnas.2208458119 |
0.205 |
|
| 2011 |
Watts KR, Morinaka BI, Amagata T, Robinson SJ, Tenney K, Bray WM, Gassner NC, Lokey RS, Media J, Valeriote FA, Crews P. Biostructural features of additional jasplakinolide (jaspamide) analogues. Journal of Natural Products. 74: 341-51. PMID 21241058 DOI: 10.1021/Np100721G |
0.203 |
|
| 2017 |
Martucci H, Campit SE, Gee SR, Bray WM, Gokey T, Cada AK, Yen TY, Minoura K, Guliaev AB, Lokey RS, Amagata T. Naphthablins B and C, Meroterpenoids Identified from the Marine Sediment-Derived Streptomyces sp. CP26-58 Using HeLa Cell-Based Cytological Profiling. Journal of Natural Products. PMID 28128950 DOI: 10.1021/acs.jnatprod.6b00996 |
0.203 |
|
| 2006 |
Rezai T, Yu B, Millhauser GL, Jacobson MP, Lokey RS. Testing the conformational hypothesis of passive membrane permeability using synthetic cyclic peptide diastereomers Journal of the American Chemical Society. 128: 2510-2511. PMID 16492015 DOI: 10.1021/Ja0563455 |
0.202 |
|
| 2017 |
Pye CR, Bertin MJ, Lokey RS, Gerwick WH, Linington RG. Retrospective analysis of natural products provides insights for future discovery trends. Proceedings of the National Academy of Sciences of the United States of America. PMID 28461474 DOI: 10.1073/Pnas.1614680114 |
0.2 |
|
| 2016 |
Bray W, Lokey RS. A High-Throughput Yeast Halo Assay for Bioactive Compounds. Cold Spring Harbor Protocols. 2016: pdb.prot088047. PMID 27587777 DOI: 10.1101/pdb.prot088047 |
0.198 |
|
| 2020 |
Klein VG, Townsend CE, Testa A, Zengerle M, Maniaci C, Hughes SJ, Chan KH, Ciulli A, Lokey RS. Understanding and Improving the Membrane Permeability of VH032-Based PROTACs. Acs Medicinal Chemistry Letters. 11: 1732-1738. PMID 32939229 DOI: 10.1021/Acsmedchemlett.0C00265 |
0.197 |
|
| 2007 |
Gassner NC, Tamble CM, Bock JE, Cotton N, White KN, Tenney K, St. Onge RP, Proctor MJ, Giaever G, Nislow C, Davis RW, Crews P, Holman TR, Lokey RS. Accelerating the discovery of biologically active small molecules using a high-throughput yeast halo assay Journal of Natural Products. 70: 383-390. PMID 17291044 DOI: 10.1021/Np060555T |
0.197 |
|
| 2007 |
Ralifo P, Sanchez L, Gassner NC, Tenney K, Lokey RS, Holman TR, Valeriote FA, Crews P. Pyrroloacridine alkaloids from Plakortis quasiamphiaster: Structures and bioactivity Journal of Natural Products. 70: 95-99. PMID 17253856 DOI: 10.1021/Np060585W |
0.194 |
|
| 2021 |
Ono S, Naylor MR, Townsend CE, Okumura C, Okada O, Lee HW, Lokey RS. Cyclosporin A: Conformational Complexity and Chameleonicity. Journal of Chemical Information and Modeling. PMID 34672629 DOI: 10.1021/acs.jcim.1c00771 |
0.191 |
|
| 2018 |
Warner CJA, Salinas M, Zamorano-Sánchez D, Bray WM, Lokey RS, Yildiz FH, Linington RG. The Bioactive Lipid (S)-Sebastenoic Acid Impacts Motility and Dispersion in . Canadian Journal of Chemistry. 96: 196-203. PMID 34158674 DOI: 10.1139/cjc-2017-0334 |
0.186 |
|
| 2016 |
Suresh S, Schlecht U, Xu W, Bray W, Miranda M, Davis RW, Nislow C, Giaever G, Lokey RS, St Onge RP. Systematic Mapping of Chemical-Genetic Interactions in Saccharomyces cerevisiae. Cold Spring Harbor Protocols. 2016: pdb.top077701. PMID 27587783 DOI: 10.1101/Pdb.Top077701 |
0.182 |
|
| 2007 |
Schuresko LA, Lokey RS. A practical solid-phase synthesis of Glu7-phalloidin and entry into fluorescent F-actin-binding reagents Angewandte Chemie - International Edition. 46: 3547-3549. PMID 17385816 DOI: 10.1002/Anie.200700017 |
0.177 |
|
| 2012 |
Zuckerman NB, Myers AS, Quan TK, Bray WM, Lokey RS, Hartzog GA, Konopelski JP. Structural Determination of NSC 670224, Synthesis of Analogues and Biological Evaluation Chemmedchem. 7: 761-765. PMID 22378491 DOI: 10.1002/Cmdc.201200038 |
0.177 |
|
| 2021 |
Lam HN, Lau T, Lentz A, Sherry J, Cabrera-Cortez A, Hug K, Lalljie A, Engel J, Lokey RS, Auerbuch V. Developing Cyclic Peptomers as Broad-Spectrum Gram-negative Bacterial Type III Secretion System Inhibitors. Antimicrobial Agents and Chemotherapy. PMID 33875435 DOI: 10.1128/AAC.01690-20 |
0.169 |
|
| 2007 |
Nehil MT, Tamble CM, Combs DJ, Kellogg DR, Lokey RS. Uncovering genetic relationships using small molecules that selectively target yeast cell cycle mutants. Chemical Biology & Drug Design. 69: 258-64. PMID 17461973 DOI: 10.1111/j.1747-0285.2007.00496.x |
0.162 |
|
| 2018 |
Ueoka R, Bhushan A, Probst SI, Bray WM, Lokey RS, Linington RG, Piel J. Genome-based identification of a plant-associated marine bacterium as a rich natural product source. Angewandte Chemie (International Ed. in English). PMID 30025185 DOI: 10.1002/Anie.201805673 |
0.146 |
|
| 2007 |
Combs DJ, Lokey RS. Extended peptoids: a new class of oligomers based on aromatic building blocks Tetrahedron Letters. 48: 2679-2682. DOI: 10.1016/j.tetlet.2007.02.075 |
0.131 |
|
| 2019 |
Lau TA, Bray WM, Lokey RS. Macrophage Cytological Profiling and Anti-Inflammatory Drug Discovery. Assay and Drug Development Technologies. 17: 14-16. PMID 30657701 DOI: 10.1089/adt.2018.894 |
0.13 |
|
| 2017 |
Pye CR, Bertin MJ, Lokey RS, Gerwick WH, Linington RG. Reply to Skinnider and Magarvey: Rates of novel natural product discovery remain high. Proceedings of the National Academy of Sciences of the United States of America. PMID 28710331 DOI: 10.1073/Pnas.1711139114 |
0.125 |
|
| 2023 |
Lau TA, Mair E, Rabbitts BM, Lohith A, Lokey RS. High-Content Image-Based Screening and Deep Learning for the Detection of Anti-Inflammatory Drug Leads. Chembiochem : a European Journal of Chemical Biology. e202300136. PMID 37815526 DOI: 10.1002/cbic.202300136 |
0.122 |
|
| 2013 |
Lokey RS, Liras J, Liras S, Jacobson MP. Designing molecules to cross biological membranes. Current Topics in Medicinal Chemistry. 13: 775. PMID 23578022 DOI: 10.2174/1568026611313070001 |
0.113 |
|
| 2022 |
Lokey RS, Pye C. Getting bifunctional molecules into cells. Science (New York, N.Y.). 378: 1054-1055. PMID 36480613 DOI: 10.1126/science.adf4412 |
0.112 |
|
| 2025 |
Menke AJ, Reibenspies JH, Patterson-Gardner CJ, Engstrom AM, Lokey RS, Simanek EE. Choreoisosteres: Pseudoatom Variation in Macrocyclic Hinges Conserves Structure and Dynamics. Acs Physical Chemistry Au. 5: 134-138. PMID 40160939 DOI: 10.1021/acsphyschemau.4c00103 |
0.111 |
|
| 2011 |
Peach KC, Bray WM, Shikuma NJ, Gassner NC, Lokey RS, Yildiz FH, Linington RG. An image-based 384-well high-throughput screening method for the discovery of biofilm inhibitors in Vibrio cholerae. Molecular Biosystems. 7: 1176-84. PMID 21246108 DOI: 10.1039/C0Mb00276C |
0.107 |
|
| 2017 |
White PM, Serbus LR, Debec A, Codina A, Bray W, Guichet A, Lokey RS, Sullivan W. Reliance of Wolbachia on High Rates of Host Proteolysis Revealed by a Genome-Wide RNAi Screen of Drosophila Cells. Genetics. PMID 28159754 DOI: 10.1534/genetics.116.198903 |
0.098 |
|
| 1989 |
Lokey RS, Mills NS, Rheingold AL. A sandwich complex containing trimethylenemethane, (η4-2-methylene-1,3-propanediyl)(η 5-2,4-cyclopentadien-1-yl)-cobalt Organometallics. 8: 1803-1805. |
0.078 |
|
| 1993 |
Lokey RH. A piece of my mind. Retrieval. Journal of the American Medical Association. 270: 32. PMID 8510288 DOI: 10.1001/jama.270.1.32 |
0.013 |
|
| 1986 |
Dacso CC, Lokey R, Wisneski V. Gas in the pelvis two months after laparotomy Hospital Practice. 21: 40-43. PMID 2868019 |
0.01 |
|
| Hide low-probability matches. |
