Lawrence A. Loeb, MD, PhD - Publications

Affiliations: 
Pathology University of Washington School of Medicine, Seattle, WA, United States 
Area:
mutations and human cancer
Website:
http://www.pathology.washington.edu/faculty/lloeb

328 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Zhang Y, Kohrn BF, Yang M, Nachmanson D, Soong TR, Lee IH, Tao Y, Clevers H, Swisher EM, Brentnall TA, Loeb LA, Kennedy SR, Salk JJ, Naxerova K, Risques RA. PolyG-DS: An ultrasensitive polyguanine tract-profiling method to detect clonal expansions and trace cell lineage. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34330826 DOI: 10.1073/pnas.2023373118  0.612
2020 Beckman RA, Loeb LA. Rare Mutations in Cancer Drug Resistance and Implications for Therapy. Clinical Pharmacology and Therapeutics. PMID 32648584 DOI: 10.1002/Cpt.1938  0.329
2019 Loeb LA, Kohrn BF, Loubet-Senear KJ, Dunn YJ, Ahn EH, O'Sullivan JN, Salk JJ, Bronner MP, Beckman RA. Extensive subclonal mutational diversity in human colorectal cancer and its significance. Proceedings of the National Academy of Sciences of the United States of America. PMID 31806761 DOI: 10.1073/Pnas.1910301116  0.673
2019 Shen JC, Kamath-Loeb AS, Kohrn BF, Loeb KR, Preston BD, Loeb LA. A high-resolution landscape of mutations in the super-enhancer in normal human B cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 31748270 DOI: 10.1073/Pnas.1914163116  0.442
2019 Salk JJ, Loubet-Senear K, Maritschnegg E, Valentine CC, Williams LN, Higgins JE, Horvat R, Vanderstichele A, Nachmanson D, Baker KT, Emond MJ, Loter E, Tretiakova M, Soussi T, Loeb LA, et al. Ultra-Sensitive TP53 Sequencing for Cancer Detection Reveals Progressive Clonal Selection in Normal Tissue over a Century of Human Lifespan. Cell Reports. 28: 132-144.e3. PMID 31269435 DOI: 10.1016/J.Celrep.2019.05.109  0.663
2019 Beckman RA, Kohrn B, Loubet-Senear K, Dunn J, OSullivan J, Bronner M, Loeb LA. Abstract 3770: Unexpectedly high subclonal mutational diversity in human colorectal cancer and its significance Cancer Research. 79: 3770-3770. DOI: 10.1158/1538-7445.Sabcs18-3770  0.444
2018 Schmitt MW, Pritchard JR, Leighow SM, Aminov BI, Beppu L, Kim DS, Hodgson JG, Rivera VM, Loeb LA, Radich J. Single-molecule sequencing reveals patterns of pre-existing drug resistance that suggest treatment strategies in Philadelphia-positive leukemias. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30042204 DOI: 10.1158/1078-0432.Ccr-18-0167  0.344
2018 Salk JJ, Schmitt MW, Loeb LA. Enhancing the accuracy of next-generation sequencing for detecting rare and subclonal mutations. Nature Reviews. Genetics. PMID 29576615 DOI: 10.1038/Nrg.2017.117  0.676
2018 Mabrey FL, Chien SS, Martins TS, Annis J, Sekizaki TS, Dai J, Beckman RA, Loeb LA, Carson A, Patay B, Blau CA, Oehler VG, Celik SS, Lee S, Monnat RJ, et al. High Throughput Drug Screening of Leukemia Stem Cells Reveals Resistance to Standard Therapies and Sensitivity to Other Agents in Acute Myeloid Leukemia Blood. 132: 180-180. DOI: 10.1182/Blood-2018-180  0.324
2017 Beckman RA, Loeb LA. Evolutionary dynamics and significance of multiple subclonal mutations in cancer. Dna Repair. PMID 28652129 DOI: 10.1016/J.Dnarep.2017.06.002  0.467
2017 Chawanthayatham S, Valentine CC, Fedeles BI, Fox EJ, Loeb LA, Levine SS, Slocum SL, Wogan GN, Croy RG, Essigmann JM. Mutational spectra of aflatoxin B1 in vivo establish biomarkers of exposure for human hepatocellular carcinoma. Proceedings of the National Academy of Sciences of the United States of America. PMID 28351974 DOI: 10.1073/Pnas.1700759114  0.389
2017 Kamath-Loeb AS, Zavala-van Rankin DG, Flores-Morales J, Emond MJ, Sidorova JM, Carnevale A, Cárdenas-Cortés MD, Norwood TH, Monnat RJ, Loeb LA, Mercado-Celis GE. Homozygosity for the WRN Helicase-Inactivating Variant, R834C, does not confer a Werner syndrome clinical phenotype. Scientific Reports. 7: 44081. PMID 28276523 DOI: 10.1038/Srep44081  0.391
2017 Krimmel J, Schmitt M, Kennedy S, Harrell M, Agnew K, Loeb L, Swisher E, Risques R. Abstract AP05: ULTRA–DEEP SEQUENCING DETECTS OVARIAN CANCER CELLS IN PERITONEAL FLUID AND REVEALS SOMATIC TP53 MUTATIONS IN NON–CANCEROUS TISSUES Clinical Cancer Research. 23. DOI: 10.1158/1557-3265.Ovcasymp16-Ap05  0.441
2017 Salk JJ, Maritschnegg E, Speiser P, Zeillinger R, Risques R, Loeb LA. Abstract 3041: Duplex Sequencing detects cancer-associated mutations arising during normal aging: Clonal evolution over a century of human lifetime Cancer Research. 77: 3041-3041. DOI: 10.1158/1538-7445.Am2017-3041  0.633
2016 Reid-Bayliss KS, Arron ST, Loeb LA, Bezrookove V, Cleaver JE. Why Cockayne syndrome patients do not get cancer despite their DNA repair deficiency. Proceedings of the National Academy of Sciences of the United States of America. PMID 27543334 DOI: 10.1073/Pnas.1610020113  0.48
2016 Loeb LA. Human Cancers Express a Mutator Phenotype: Hypothesis, Origin, and Consequences. Cancer Research. 76: 2057-9. PMID 27197248 DOI: 10.1158/0008-5472.Can-16-0794  0.373
2016 Ahn EH, Lee SH, Kim JY, Chang CC, Loeb LA. Decreased mitochondrial mutagenesis during transformation of breast stem cells into tumorigenic cells. Cancer Research. PMID 27197159 DOI: 10.1158/0008-5472.Can-15-3462  0.387
2016 Krimmel JD, Schmitt MW, Harrell MI, Agnew KJ, Kennedy SR, Emond MJ, Loeb LA, Swisher EM, Risques RA. Ultra-deep sequencing detects ovarian cancer cells in peritoneal fluid and reveals somatic TP53 mutations in noncancerous tissues. Proceedings of the National Academy of Sciences of the United States of America. PMID 27152024 DOI: 10.1073/Pnas.1601311113  0.416
2016 Fox EJ, Salk JJ, Loeb LA. Exploring the implications of distinct mutational signatures and mutation rates in aging and cancer. Genome Medicine. 8: 30. PMID 26987311 DOI: 10.1186/S13073-016-0286-Z  0.645
2016 Pritchard JR, Schmitt MW, Hodgson JG, Lustgarten S, Tang S, Loeb LA, Radich JP, Rivera VM. Analysis of the Sub-Clonal Origins of Compound Mutations in Patients with Refractory Ph+ Malignancies Treated with Ponatinib Blood. 128: 1061-1061. DOI: 10.1182/Blood.V128.22.1061.1061  0.375
2016 Ahn EH, Hirohata K, Lee SH, Kim JY, Kohrn BF, Fox EJ, Chang C, Loeb LA. Abstract A29: Detection of ultra-rare mutations during breast stem cell tumor progression by Duplex Sequencing Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Advbc15-A29  0.414
2016 Fox EJP, Schmitt MW, Reid-Bayliss KS, Beckman RA, Loeb LA. Abstract LB-338: Extensive subclonal mutations in human colorectal cancers detected by duplex sequencing Cancer Research. 76: 3377-3377. DOI: 10.1158/1538-7445.Am2016-Lb-338  0.487
2016 Schmitt MW, Salk JJ, Fox EJ, Pritchard JR, Hodgson JG, Rivera VM, Becker PS, Radich JP, Loeb LA. Abstract 2395: Direct assessment of sequence heterogeneity in human cancers by Duplex Sequencing Cancer Research. 76: 2395-2395. DOI: 10.1158/1538-7445.Am2016-2395  0.662
2015 Schmitt MW, Loeb LA, Salk JJ. The influence of subclonal resistance mutations on targeted cancer therapy. Nature Reviews. Clinical Oncology. PMID 26483300 DOI: 10.1038/Nrclinonc.2015.175  0.567
2015 Ahn EH, Hirohata K, Kohrn BF, Fox EJ, Chang CC, Loeb LA. Detection of Ultra-Rare Mitochondrial Mutations in Breast Stem Cells by Duplex Sequencing. Plos One. 10: e0136216. PMID 26305705 DOI: 10.1371/Journal.Pone.0136216  0.423
2015 Schmitt MW, Fox EJ, Prindle MJ, Reid-Bayliss KS, True LD, Radich JP, Loeb LA. Sequencing small genomic targets with high efficiency and extreme accuracy. Nature Methods. 12: 423-5. PMID 25849638 DOI: 10.1038/Nmeth.3351  0.381
2015 Becker PS, Schmitt MW, Loeb LA, Gu W, Wei Q, Xie Z, Carson AR, Martins T, Blau CA, Oehler V, Yeung KY. Correlation of genomic analysis by MyAML with chemotherapy drug sensitivity. Journal of Clinical Oncology. 33: 7080-7080. DOI: 10.1200/Jco.2015.33.15_Suppl.7080  0.317
2015 Schmitt MW, Pritchard JR, Hodgson G, Rivera VM, Aminov BI, Beppu L, Loeb LA, Radich JP. Emergence of Sub-Clonal Drug Resistance Mutations during CML Therapy Blood. 126: 478-478. DOI: 10.1182/Blood.V126.23.478.478  0.445
2015 Schmitt MW, Fox EJ, Prindle MJ, –Bayliss KSR, Becker PS, Loeb LA. Abstract LB-283: Human cancers harbor extensive subclonal mutations Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-Lb-283  0.515
2015 Loeb LA, Schmitt MW, Prindle MJ, Becker PS. Abstract 4890: Duplex sequencing of AML reveals extensive sub clonal heterogeneity Cancer Research. 75: 4890-4890. DOI: 10.1158/1538-7445.Am2015-4890  0.494
2014 Kennedy SR, Schmitt MW, Fox EJ, Kohrn BF, Salk JJ, Ahn EH, Prindle MJ, Kuong KJ, Shen JC, Risques RA, Loeb LA. Corrigendum: Detecting ultralow-frequency mutations by Duplex Sequencing. Nature Protocols. 9: 2903. PMID 25411958 DOI: 10.1038/Nprot1214-2903D  0.598
2014 Kennedy SR, Schmitt MW, Fox EJ, Kohrn BF, Salk JJ, Ahn EH, Prindle MJ, Kuong KJ, Shen JC, Risques RA, Loeb LA. Detecting ultralow-frequency mutations by Duplex Sequencing. Nature Protocols. 9: 2586-606. PMID 25299156 DOI: 10.1038/Nprot.2014.170  0.687
2014 Fox EJ, Loeb LA. Cancer: One cell at a time. Nature. 512: 143-4. PMID 25079325 DOI: 10.1038/Nature13650  0.37
2014 Kamath-Loeb AS, Balakrishna S, Whittington D, Shen JC, Emond MJ, Okabe T, Masutani C, Hanaoka F, Nishimura S, Loeb LA. Sphingosine, a modulator of human translesion DNA polymerase activity. The Journal of Biological Chemistry. 289: 21663-72. PMID 24928506 DOI: 10.1074/Jbc.M114.570242  0.462
2014 Shen JC, Fox EJ, Ahn EH, Loeb LA. A rapid assay for measuring nucleotide excision repair by oligonucleotide retrieval. Scientific Reports. 4: 4894. PMID 24809800 DOI: 10.1038/Srep04894  0.498
2014 Prindle MJ, Loeb LA, Estey EH, Becker PS. Targeted Ultra-Deep High Accuracy Sequencing of Pre-Treatment AML Reveals a Diversity of Mutational Phenotypes and Evidence of Preexisting Relapse-Associated Subclones Blood. 124: 2372-2372. DOI: 10.1182/Blood.V124.21.2372.2372  0.514
2013 Salk JJ, Bansal A, Lai LA, Crispin DA, Ussakli CH, Horwitz MS, Bronner MP, Brentnall TA, Loeb LA, Rabinovitch PS, Risques RA. Clonal expansions and short telomeres are associated with neoplasia in early-onset, but not late-onset, ulcerative colitis. Inflammatory Bowel Diseases. 19: 2593-602. PMID 24097228 DOI: 10.1097/Mib.0B013E3182A87640  0.583
2013 Kennedy SR, Salk JJ, Schmitt MW, Loeb LA. Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage. Plos Genetics. 9: e1003794. PMID 24086148 DOI: 10.1371/Journal.Pgen.1003794  0.699
2013 Lao VV, Welcsh P, Luo Y, Carter KT, Dzieciatkowski S, Dintzis S, Meza J, Sarvetnick NE, Monnat RJ, Loeb LA, Grady WM. Altered RECQ Helicase Expression in Sporadic Primary Colorectal Cancers. Translational Oncology. 6: 458-69. PMID 23908689 DOI: 10.1593/Tlo.13238  0.342
2013 Weedon MN, Ellard S, Prindle MJ, Caswell R, Allen HL, Oram R, Godbole K, Yajnik CS, Sbraccia P, Novelli G, Turnpenny P, McCann E, Goh KJ, Wang Y, Fulford J, ... ... Loeb LA, et al. An in-frame deletion at the polymerase active site of POLD1 causes a multisystem disorder with lipodystrophy Nature Genetics. 45: 947-950. PMID 23770608 DOI: 10.1038/Ng.2670  0.514
2013 Fox EJ, Prindle MJ, Loeb LA. Do mutator mutations fuel tumorigenesis? Cancer Metastasis Reviews. 32: 353-61. PMID 23592419 DOI: 10.1007/S10555-013-9426-8  0.413
2013 Prindle MJ, Schmitt MW, Parmeggiani F, Loeb LA. A substitution in the fingers domain of dna polymerase reduces fidelity by altering nucleotide discrimination in the catalytic site Journal of Biological Chemistry. 288: 5572-5580. PMID 23283971 DOI: 10.1074/Jbc.M112.436410  0.498
2013 Loeb LA, Fox EJ, Kennedy SR, Kuong J, Schmitt MW, Salk JJ. Abstract 1789A: Duplex DNA sequencing detects subclonal and ultra-rare mutations in human tumors. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-1789A  0.663
2012 Prindle MJ, Loeb LA. DNA polymerase delta in dna replication and genome maintenance Environmental and Molecular Mutagenesis. 53: 666-682. PMID 23065663 DOI: 10.1002/Em.21745  0.477
2012 Schmitt MW, Prindle MJ, Loeb LA. Implications of genetic heterogeneity in cancer Annals of the New York Academy of Sciences. 1267: 110-116. PMID 22954224 DOI: 10.1111/J.1749-6632.2012.06590.X  0.509
2012 Schmitt MW, Kennedy SR, Salk JJ, Fox EJ, Hiatt JB, Loeb LA. Detection of ultra-rare mutations by next-generation sequencing. Proceedings of the National Academy of Sciences of the United States of America. 109: 14508-13. PMID 22853953 DOI: 10.1073/Pnas.1208715109  0.695
2012 Kamath-Loeb AS, Shen JC, Schmitt MW, Loeb LA. The Werner syndrome exonuclease facilitates DNA degradation and high fidelity DNA polymerization by human DNA polymerase δ Journal of Biological Chemistry. 287: 12480-12490. PMID 22351772 DOI: 10.1074/Jbc.M111.332577  0.505
2012 Kamath-Loeb A, Loeb LA, Fry M. The Werner syndrome protein is distinguished from the Bloom syndrome protein by its capacity to tightly bind diverse DNA structures. Plos One. 7: e30189. PMID 22272300 DOI: 10.1371/Journal.Pone.0030189  0.446
2012 Kennedy SR, Loeb LA, Herr AJ. Somatic mutations in aging, cancer and neurodegeneration Mechanisms of Ageing and Development. 133: 118-126. PMID 22079405 DOI: 10.1016/J.Mad.2011.10.009  0.401
2011 Allen JM, Simcha DM, Ericson NG, Alexander DL, Marquette JT, Van Biber BP, Troll CJ, Karchin R, Bielas JH, Loeb LA, Camps M. Roles of DNA polymerase I in leading and lagging-strand replication defined by a high-resolution mutation footprint of ColE1 plasmid replication. Nucleic Acids Research. 39: 7020-33. PMID 21622658 DOI: 10.1093/Nar/Gkr157  0.831
2011 Loeb LA. Human cancers express mutator phenotypes: Origin, consequences and targeting Nature Reviews Cancer. 11: 450-457. PMID 21593786 DOI: 10.1038/Nrc3063  0.453
2011 Kennedy SR, Chen CY, Schmitt MW, Bower CN, Loeb LA. The biochemistry and fidelity of synthesis by the apicoplast genome replication DNA polymerase Pfprex from the malaria parasite Plasmodium falciparum. Journal of Molecular Biology. 410: 27-38. PMID 21570407 DOI: 10.1016/J.Jmb.2011.04.071  0.505
2011 Wright JH, Modjeski KL, Bielas JH, Preston BD, Fausto N, Loeb LA, Campbell JS. A random mutation capture assay to detect genomic point mutations in mouse tissue Nucleic Acids Research. 39: e73. PMID 21459851 DOI: 10.1093/Nar/Gkr142  0.43
2011 Mullins JI, Heath L, Hughes JP, Kicha J, Styrchak S, Wong KG, Rao U, Hansen A, Harris KS, Laurent JP, Li D, Simpson JH, Essigmann JM, Loeb LA, Parkins J. Mutation of HIV-1 genomes in a clinical population treated with the mutagenic nucleoside KP1461. Plos One. 6: e15135. PMID 21264288 DOI: 10.1371/Journal.Pone.0015135  0.387
2011 Mullins JI, Heath L, Hughes JP, Li D, Essigmann JM, Harris KS, Simpson JH, Laurent J, Loeb LA, Parkins J. Mutations based on viral decay acceleration in the HIV-1 genomes of a clinical population treated with the mutagenic nucleoside KP1461 Retrovirology. 8. DOI: 10.1186/1742-4690-8-S2-P84  0.388
2011 Fox EJ, Shen J, Loeb LA. Abstract 5493: Lethal mutagenesis of cancer cells by nucleoside analogs Cancer Research. 71: 5493-5493. DOI: 10.1158/1538-7445.Am2011-5493  0.535
2010 Loeb LA. Mutator phenotype in cancer: Origin and consequences Seminars in Cancer Biology. 20: 279-280. PMID 20937389 DOI: 10.1016/J.Semcancer.2010.10.006  0.509
2010 Fox EJ, Loeb LA. Lethal mutagenesis: targeting the mutator phenotype in cancer. Seminars in Cancer Biology. 20: 353-9. PMID 20934515 DOI: 10.1016/J.Semcancer.2010.10.005  0.423
2010 Prindle MJ, Fox EJ, Loeb LA. The mutator phenotype in cancer: molecular mechanisms and targeting strategies. Current Drug Targets. 11: 1296-303. PMID 20840072 DOI: 10.2174/1389450111007011296  0.481
2010 Fox EJ, Beckman RA, Loeb LA. Reply: Is There Any Genetic Instability in Human Cancer? Dna Repair. 9: 859-860. PMID 20703319 DOI: 10.1016/J.Dnarep.2010.05.006  0.445
2010 Schmitt MW, Venkatesan RN, Pillaire MJ, Hoffmann JS, Sidorova JM, Loeb LA. Active site mutations in mammalian DNA polymerase δ alter accuracy and replication fork progression Journal of Biological Chemistry. 285: 32264-32272. PMID 20628184 DOI: 10.1074/Jbc.M110.147017  0.522
2010 Loeb LA, Nishimura S. Princess Takamatsu symposium on DNA repair and human cancers Cancer Research. 70: 4269-4273. PMID 20460534 DOI: 10.1158/0008-5472.Can-10-0320  0.467
2010 Gorman S, Fox E, O'Donoghue D, Sheahan K, Hyland J, Mulcahy H, Loeb LA, O'Sullivan J. Mitochondrial mutagenesis induced by tumor-specific radiation bystander effects Journal of Molecular Medicine. 88: 701-708. PMID 20349220 DOI: 10.1007/S00109-010-0616-3  0.353
2010 Klapacz J, Lingaraju GM, Guo HH, Shah D, Moar-Shoshani A, Loeb LA, Samson LD. Frameshift Mutagenesis and Microsatellite Instability Induced by Human Alkyladenine DNA Glycosylase Molecular Cell. 37: 843-853. PMID 20347426 DOI: 10.1016/J.Molcel.2010.01.038  0.669
2010 Loh E, Salk JJ, Loeb LA. Optimization of DNA polymerase mutation rates during bacterial evolution. Proceedings of the National Academy of Sciences of the United States of America. 107: 1154-9. PMID 20080608 DOI: 10.1073/Pnas.0912451107  0.749
2010 Hsu JJ, Kamath-Loeb AS, Glick E, Wallden B, Swisshelm K, Rubin BP, Loeb LA. Werner syndrome gene variants in human sarcomas Molecular Carcinogenesis. 49: 166-174. PMID 19824023 DOI: 10.1002/Mc.20586  0.428
2010 Salk JJ, Fox EJ, Loeb LA. Mutational heterogeneity in human cancers: origin and consequences. Annual Review of Pathology. 5: 51-75. PMID 19743960 DOI: 10.1146/Annurev-Pathol-121808-102113  0.634
2010 Loeb LA, Schmitt MW, Venkatesan RN, Pillaire M, Hoffmann J. Abstract 241: A mutant DNA polymerase-delta associated with increased tumor progression causes random deletions in DNA Cancer Research. 70: 241-241. DOI: 10.1158/1538-7445.Am10-241  0.547
2009 Vermulst M, Wanagat J, Loeb LA. On Mitochondria, Mutations, and Methodology Cell Metabolism. 10: 437. PMID 19945399 DOI: 10.1016/J.Cmet.2009.11.001  0.764
2009 Salk JJ, Salipante SJ, Risques RA, Crispin DA, Li L, Bronner MP, Brentnall TA, Rabinovitch PS, Horwitz MS, Loeb LA. Clonal expansions in ulcerative colitis identify patients with neoplasia. Proceedings of the National Academy of Sciences of the United States of America. 106: 20871-6. PMID 19926851 DOI: 10.1073/Pnas.0909428106  0.626
2009 Schmitt MW, Matsumoto Y, Loeb LA. High fidelity and lesion bypass capability of human DNA polymerase δ Biochimie. 91: 1163-1172. PMID 19540301 DOI: 10.1016/J.Biochi.2009.06.007  0.517
2009 Fox EJ, Salk JJ, Loeb LA. Cancer genome sequencing--an interim analysis. Cancer Research. 69: 4948-50. PMID 19509220 DOI: 10.1158/0008-5472.Can-09-1231  0.596
2009 Dai DF, Santana LF, Vermulst M, Tomazela DM, Emond MJ, MacCoss MJ, Gollahon K, Martin GM, Loeb LA, Ladiges WC, Rabinovitch PS. Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging. Circulation. 119: 2789-97. PMID 19451351 DOI: 10.1161/Circulationaha.108.822403  0.73
2008 Vermulst M, Bielas JH, Loeb LA. Quantification of random mutations in the mitochondrial genome Methods. 46: 263-268. PMID 18948200 DOI: 10.1016/J.Ymeth.2008.10.008  0.775
2008 Chen CY, Guo HH, Shah D, Blank A, Samson LD, Loeb LA. Substrate binding pocket residues of human alkyladenine-DNA glycosylase critical for methylating agent survival Dna Repair. 7: 1731-1745. PMID 18706524 DOI: 10.1016/J.Dnarep.2008.06.019  0.611
2008 Loeb LA, Monnat RJ. DNA polymerases and human disease Nature Reviews Genetics. 9: 594-604. PMID 18626473 DOI: 10.1038/Nrg2345  0.497
2008 Compton SA, Tolun G, Kamath-Loeb AS, Loeb LA, Griffith JD. The Werner syndrome protein binds replication fork and Holliday junction DNAs as an oligomer Journal of Biological Chemistry. 283: 24478-24483. PMID 18596042 DOI: 10.1074/Jbc.M803370200  0.485
2008 Loeb LA, Bielas JH, Beckman RA. Cancers exhibit a mutator phenotype: Clinical implications Cancer Research. 68: 3551-3557. PMID 18483233 DOI: 10.1158/0008-5472.Can-07-5835  0.429
2008 Vermulst M, Wanagat J, Kujoth GC, Bielas JH, Rabinovitch PS, Prolla TA, Loeb LA. DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice Nature Genetics. 40: 392-394. PMID 18311139 DOI: 10.1038/Ng.95  0.796
2007 Camps M, Herman A, Loh E, Loeb LA. Genetic constraints on protein evolution. Critical Reviews in Biochemistry and Molecular Biology. 42: 313-26. PMID 17917869 DOI: 10.1080/10409230701597642  0.73
2007 Venkatesan RN, Treuting PM, Fuller ED, Goldsby RE, Norwood TH, Gooley TA, Ladiges WC, Preston BD, Loeb LA. Mutation at the polymerase active site of mouse DNA polymerase δ increases genomic instability and accelerates tumorigenesis Molecular and Cellular Biology. 27: 7669-7682. PMID 17785453 DOI: 10.1128/Mcb.00002-07  0.503
2007 Kamath-Loeb AS, Lan L, Nakajima S, Yasui A, Loeb LA. Werner syndrome protein interacts functionally with translesion DNA polymerases Proceedings of the National Academy of Sciences of the United States of America. 104: 10394-10399. PMID 17563354 DOI: 10.1073/Pnas.0702513104  0.451
2007 Vermulst M, Bielas JH, Kujoth GC, Ladiges WC, Rabinovitch PS, Prolla TA, Loeb LA. Mitochondrial point mutations do not limit the natural lifespan of mice Nature Genetics. 39: 540-543. PMID 17334366 DOI: 10.1038/Ng1988  0.771
2007 Bielas JH, Venkatesan RN, Loeb LA. LOH-proficient embryonic stem cells: a model of cancer progenitor cells? Trends in Genetics. 23: 154-157. PMID 17328987 DOI: 10.1016/J.Tig.2007.02.009  0.331
2007 Loh E, Choe J, Loeb LA. Highly tolerated amino acid substitutions increase the fidelity of Escherichia coli DNA polymerase I. The Journal of Biological Chemistry. 282: 12201-9. PMID 17301051 DOI: 10.1074/Jbc.M611294200  0.699
2006 Bielas JH, Loeb KR, Rubin BP, 1 LD, Loeb LA. Human cancers express a mutator phenotype Proceedings of the National Academy of Sciences of the United States of America. 103: 18238-18242. PMID 17108085 DOI: 10.1073/Pnas.0607057103  0.433
2006 Beckman RA, Loeb LA. Efficiency of carcinogenesis with and without a mutator mutation Proceedings of the National Academy of Sciences of the United States of America. 103: 14140-14145. PMID 16966602 DOI: 10.1073/Pnas.0606271103  0.427
2006 Glick E, White LM, Elliott NA, Berg D, Kiviat NB, Loeb LA. Mutations in DNA polymerase η are not detected in squamous cell carcinoma of the skin International Journal of Cancer. 119: 2225-2227. PMID 16823845 DOI: 10.1002/Ijc.22099  0.481
2006 Fontes AM, Davis BM, Encell LP, Lingas K, Covas DT, Zago MA, Loeb LA, Pegg AE, Gerson SL. Differential competitive resistance to methylating versus chloroethylating agents among five O6-alkylguanine DNA alkyltransferases in human hematopoietic cells. Molecular Cancer Therapeutics. 5: 121-8. PMID 16432170 DOI: 10.1158/1535-7163.Mct-05-0236  0.31
2006 Venkatesan RN, Bielas JH, Loeb LA. Generation of mutator mutants during carcinogenesis Dna Repair. 5: 294-302. PMID 16359931 DOI: 10.1016/J.Dnarep.2005.10.012  0.444
2006 Venkatesan RN, Hsu JJ, Lawrence NA, Preston BD, Loeb LA. Mutator phenotypes caused by substitution at a conserved motif A residue in eukaryotic DNA polymerase Journal of Biological Chemistry. 281: 4486-4494. PMID 16344551 DOI: 10.1074/Jbc.M510245200  0.536
2006 Hansen AB, Griner NB, Anderson JP, Kujoth GC, Prolla TA, Loeb LA, Glick E. Mitochondrial DNA integrity is not dependent on DNA polymerase-β activity Dna Repair. 5: 71-79. PMID 16165404 DOI: 10.1016/J.Dnarep.2005.07.009  0.502
2006 Kamath-Loeb AS, Loeb LA, Fry M. 22 DNA Helicases and Human Disease Cold Spring Harbor Monograph Archive. 47: 435-460. DOI: 10.1101/087969766.47.435  0.492
2006 Bielas JH, Loeb KR, Rubin BP, True LD, Loeb LA. Erratum: Human cancers express a mutator phenotype (Proceedings of the National Academy of Sciences of the United States of America (November 28, 2006) 103, 48 (18238-18242) DOI: 10.1073/pnas.0607057103) Proceedings of the National Academy of Sciences of the United States of America. 103. DOI: 10.1073/Pnas.0610370103  0.336
2005 Venkatesan RN, Loeb LA. The multiplicity of mutations in human cancers Advances in Experimental Medicine and Biology. 570: 3-17. PMID 18727496 DOI: 10.1007/1-4020-3764-3_1  0.433
2005 Loeb LA, Wallace DC, Martin GM. The mitochondrial theory of aging and its relationship to reactive oxygen species damage and somatic mtDNA mutations Proceedings of the National Academy of Sciences of the United States of America. 102: 18769-18770. PMID 16365283 DOI: 10.1073/Pnas.0509776102  0.438
2005 Loh E, Loeb LA. Mutability of DNA polymerase I: implications for the creation of mutant DNA polymerases. Dna Repair. 4: 1390-8. PMID 16230053 DOI: 10.1016/J.Dnarep.2005.09.006  0.685
2005 Beckman RA, Loeb LA. Negative clonal selection in tumor evolution Genetics. 171: 2123-2131. PMID 16143627 DOI: 10.1534/Genetics.105.040840  0.429
2005 Beckman RA, Loeb LA. Genetic instability in cancer: Theory and experiment Seminars in Cancer Biology. 15: 423-435. PMID 16043359 DOI: 10.1016/J.Semcancer.2005.06.007  0.389
2005 Kamath-Loeb AS, Masuda Y, Hanaoka F, Loeb LA. The first US-Japan meeting on error-prone DNA synthesis, Maui, Hawaii, December 20-21, 2004 Dna Repair. 4: 740-747. PMID 15981324 DOI: 10.1016/J.Dnarep.2005.02.003  0.378
2005 Ozgenc A, Loeb LA. Current advances in unraveling the function of the Werner syndrome protein Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 577: 237-251. PMID 15946710 DOI: 10.1016/J.Mrfmmm.2005.03.020  0.472
2005 Bielas JH, Loeb LA. Quantification of random genomic mutations Nature Methods. 2: 285-290. PMID 15782221 DOI: 10.1038/Nmeth751  0.468
2005 Anderson JP, Angerer B, Loeb LA. Incorporation of reporter-labeled nucleotides by DNA polymerases Biotechniques. 38: 257-264. PMID 15727132 DOI: 10.2144/05382Rr02  0.436
2005 Bielas JH, Loeb LA. Mutator phenotype in cancer: Timing and perspectives Environmental and Molecular Mutagenesis. 45: 206-213. PMID 15672382 DOI: 10.1002/Em.20111  0.484
2005 Camps M, Loeb LA. Critical role of R-loops in processing replication blocks. Frontiers in Bioscience : a Journal and Virtual Library. 10: 689-698. PMID 15569610 DOI: 10.2741/1564  0.643
2004 Kamath-Loeb AS, Welcsh P, Waite M, Adman ET, Loeb LA. The enzymatic activities of the Werner syndrome protein are disabled by the amino acid polymorphism R834C Journal of Biological Chemistry. 279: 55499-55505. PMID 15489508 DOI: 10.1074/Jbc.M407128200  0.446
2004 Wogan GN, Hecht SS, Felton JS, Conney AH, Loeb LA. Environmental and chemical carcinogenesis. Seminars in Cancer Biology. 14: 473-86. PMID 15489140 DOI: 10.1016/J.Semcancer.2004.06.010  0.422
2004 Anderson JP, Daifuku R, Loeb LA. Viral error catastrophe by mutagenic nucleosides Annual Review of Microbiology. 58: 183-205. PMID 15487935 DOI: 10.1146/Annurev.Micro.58.030603.123649  0.344
2004 Sneeden JL, Loeb LA. Mutations in the R2 subunit of ribonucleotide reductase that confer resistance to hydroxyurea Journal of Biological Chemistry. 279: 40723-40728. PMID 15262976 DOI: 10.1074/Jbc.M402699200  0.781
2004 Guo HH, Choe J, Loeb LA. Protein tolerance to random amino acid change Proceedings of the National Academy of Sciences of the United States of America. 101: 9205-9210. PMID 15197260 DOI: 10.1073/Pnas.0403255101  0.612
2004 Martin GM, Loeb LA. Mice and mitochondria Nature. 429: 357-359. PMID 15164048 DOI: 10.1038/429357A  0.414
2004 Blank A, Bobola MS, Gold B, Varadarajan S, D Kolstoe D, Meade EH, Rabinovitch PS, Loeb LA, Silber JR. The Werner syndrome protein confers resistance to the DNA lesions N3-methyladenine and O6-methylguanine: implications for WRN function. Dna Repair. 3: 629-38. PMID 15135730 DOI: 10.1016/J.Dnarep.2004.02.003  0.449
2004 Camps M, Loeb LA. When Pol I goes into high gear: Processive DNA synthesis by Pol I in the cell Cell Cycle. 3: 116-118. PMID 14712068  0.665
2003 Camps M, Loeb LA. Targeted mutagenesis in E. coli: A powerful tool for the generation of random mutant libraries. Discovery Medicine. 3: 36-7. PMID 20704859  0.631
2003 Guo HH, Loeb LA. Tumbling down a different pathway to genetic instability Journal of Clinical Investigation. 112: 1793-1795. PMID 14679175 DOI: 10.1172/Jci20502  0.602
2003 Shen JC, Lao Y, Kamath-Loeb A, Wold MS, Loeb LA. The N-terminal domain of the large subunit of human replication protein A binds to Werner syndrome protein and stimulates helicase activity. Mechanisms of Ageing and Development. 124: 921-30. PMID 14499497 DOI: 10.1016/S0047-6374(03)00164-7  0.431
2003 Shen JC, Loeb LA. Mutations in the α8 Loop of Human APE1 Alter Binding and Cleavage of DNA Containing an Abasic Site Journal of Biological Chemistry. 278: 46994-47001. PMID 12966083 DOI: 10.1074/Jbc.M309362200  0.431
2003 Camps M, Naukkarinen J, Johnson BP, Loeb LA. Targeted gene evolution in Escherichia coli using a highly error-prone DNA polymerase I Proceedings of the National Academy of Sciences of the United States of America. 100: 9727-9732. PMID 12909725 DOI: 10.1073/Pnas.1333928100  0.681
2003 Davidson JF, Fox R, Harris DD, Lyons-Abbott S, Loeb LA. Insertion of the T3 DNA polymerase thioredoxin binding domain enhances the processivity and fidelity of Taq DNA polymerase Nucleic Acids Research. 31: 4702-4709. PMID 12907710 DOI: 10.1093/Nar/Gkg667  0.482
2003 Sneeden JL, Loeb LA. Random oligonucleotide mutagenesis. Methods in Molecular Biology (Clifton, N.J.). 231: 65-73. PMID 12824603 DOI: 10.1385/1-59259-395-X:65  0.765
2003 Venkatesan RN, Loeb LA. Selection of novel eukaryotic DNA polymerases by mutagenesis and genetic complementation of yeast. Methods in Molecular Biology (Clifton, N.J.). 230: 19-26. PMID 12824566 DOI: 10.1385/1-59259-396-8:19  0.437
2003 Camps M, Loeb LA. Use of Pol I-deficient E. coli for functional complementation of DNA polymerase. Methods in Molecular Biology (Clifton, N.J.). 230: 11-18. PMID 12824565 DOI: 10.1385/1-59259-396-8:11  0.645
2003 Sneeden JL, Loeb LA. Genetic complementation protocols. Methods in Molecular Biology (Clifton, N.J.). 230: 3-10. PMID 12824564 DOI: 10.1385/1-59259-396-8:3  0.746
2003 Glick E, Chau JS, Vigna KL, McCulloch SD, Adman ET, Kunkel TA, Loeb LA. Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. The Journal of Biological Chemistry. 278: 19341-6. PMID 12644469 DOI: 10.1074/Jbc.M300686200  0.491
2003 Loeb LA, Loeb KR, Anderson JP. Multiple mutations and cancer. Proceedings of the National Academy of Sciences of the United States of America. 100: 776-81. PMID 12552134 DOI: 10.1073/Pnas.0334858100  0.411
2003 Sneeden JL, Loeb LA. Probing the mechanism of radical abstraction of the small subunit of E. coli ribonucleotide reductase Journal of Inorganic Biochemistry. 96: 233. DOI: 10.1016/S0162-0134(03)80775-4  0.754
2002 Glick E, Anderson JP, Loeb LA. In vitro production and screening of DNA polymerase eta mutants for catalytic diversity. Biotechniques. 33: 1136-42, 1144. PMID 12449395 DOI: 10.2144/02335Dd08  0.414
2002 Davidson JF, Guo HH, Loeb LA. Endogenous mutagenesis and cancer. Mutation Research. 509: 17-21. PMID 12427528 DOI: 10.1016/S0027-5107(02)00228-2  0.644
2002 Kawate H, Landis DM, Loeb LA. Distribution of mutations in human thymidylate synthase yielding resistance to 5-fluorodeoxyuridine. The Journal of Biological Chemistry. 277: 36304-11. PMID 12147691 DOI: 10.1074/Jbc.M204956200  0.404
2002 Yang Q, Zhang R, Wang XW, Spillare EA, Linke SP, Subramanian D, Griffith JD, Li JL, Hickson ID, Shen JC, Loeb LA, Mazur SJ, Appella E, Brosh RM, Karmakar P, et al. The processing of Holliday junctions by BLM and WRN helicases is regulated by p53. The Journal of Biological Chemistry. 277: 31980-7. PMID 12080066 DOI: 10.1074/Jbc.M204111200  0.427
2002 Bergoglio V, Pillaire MJ, Lacroix-Triki M, Raynaud-Messina B, Canitrot Y, Bieth A, Garès M, Wright M, Delsol G, Loeb LA, Cazaux C, Hoffmann JS. Deregulated DNA polymerase beta induces chromosome instability and tumorigenesis. Cancer Research. 62: 3511-4. PMID 12067997  0.315
2001 Glick E, Vigna KL, Loeb LA. Mutations in human DNA polymerase eta motif II alter bypass of DNA lesions. The Embo Journal. 20: 7303-12. PMID 11743006 DOI: 10.1093/Emboj/20.24.7303  0.499
2001 Shinkai A, Loeb LA. In vivo mutagenesis by Escherichia coli DNA polymerase I. Ile(709) in motif A functions in base selection. The Journal of Biological Chemistry. 276: 46759-64. PMID 11602576 DOI: 10.1074/Jbc.M104780200  0.513
2001 Patel PH, Loeb LA. Getting a grip on how DNA polymerases function. Nature Structural Biology. 8: 656-9. PMID 11473246 DOI: 10.1038/90344  0.648
2001 Jackson AL, Loeb LA. The contribution of endogenous sources of DNA damage to the multiple mutations in cancer. Mutation Research. 477: 7-21. PMID 11376682 DOI: 10.1016/S0027-5107(01)00091-4  0.519
2001 Skandalis A, Loeb LA. Enzymatic properties of rat DNA polymerase beta mutants obtained by randomized mutagenesis. Nucleic Acids Research. 29: 2418-26. PMID 11376161 DOI: 10.1093/Nar/29.11.2418  0.417
2001 Patel PH, Suzuki M, Adman E, Shinkai A, Loeb LA. Prokaryotic DNA polymerase I: evolution, structure, and "base flipping" mechanism for nucleotide selection. Journal of Molecular Biology. 308: 823-37. PMID 11352575 DOI: 10.1006/Jmbi.2001.4619  0.662
2001 Shen J, Loeb LA. Unwinding the molecular basis of the Werner syndrome. Mechanisms of Ageing and Development. 122: 921-44. PMID 11348659 DOI: 10.1016/S0047-6374(01)00248-2  0.479
2001 Loeb LA. A mutator phenotype in cancer. Cancer Research. 61: 3230-9. PMID 11309271  0.331
2001 Davis BM, Encell LP, Zielske SP, Christians FC, Liu L, Friebert SE, Loeb LA, Gerson SL. Applied molecular evolution of O6-benzylguanine-resistant DNA alkyltransferases in human hematopoietic cells. Proceedings of the National Academy of Sciences of the United States of America. 98: 4950-4. PMID 11296271 DOI: 10.1073/Pnas.091601198  0.372
2001 Kamath-Loeb AS, Loeb LA, Johansson E, Burgers PM, Fry M. Interactions between the Werner syndrome helicase and DNA polymerase delta specifically facilitate copying of tetraplex and hairpin structures of the d(CGG)n trinucleotide repeat sequence. The Journal of Biological Chemistry. 276: 16439-46. PMID 11279038 DOI: 10.1074/jbc.M100253200  0.36
2001 Shinkai A, Patel PH, Loeb LA. The conserved active site motif A of Escherichia coli DNA polymerase I is highly mutable. The Journal of Biological Chemistry. 276: 18836-42. PMID 11278911 DOI: 10.1074/Jbc.M011472200  0.69
2001 Patel PH, Kawate H, Adman E, Ashbach M, Loeb LA. A single highly mutable catalytic site amino acid is critical for DNA polymerase fidelity. The Journal of Biological Chemistry. 276: 5044-51. PMID 11069916 DOI: 10.1074/Jbc.M008701200  0.648
2000 Patel PH, Loeb LA. Multiple amino acid substitutions allow DNA polymerases to synthesize RNA. The Journal of Biological Chemistry. 275: 40266-72. PMID 11005812 DOI: 10.1074/Jbc.M005757200  0.651
2000 Shen JC, Loeb LA. Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA. Nucleic Acids Research. 28: 3260-8. PMID 10954593 DOI: 10.1093/Nar/28.17.3260  0.466
2000 Suzuki M, Yoshida S, Adman ET, Blank A, Loeb LA. Thermus aquaticus DNA polymerase I mutants with altered fidelity. Interacting mutations in the O-helix. The Journal of Biological Chemistry. 275: 32728-35. PMID 10906120 DOI: 10.1074/Jbc.M000097200  0.439
2000 Encell LP, Loeb LA. Enhanced in vivo repair of O(4)-methylthymine by a mutant human DNA alkyltransferase. Carcinogenesis. 21: 1397-402. PMID 10874019 DOI: 10.1093/Carcin/21.7.1397  0.357
2000 Patel PH, Loeb LA. DNA polymerase active site is highly mutable: evolutionary consequences. Proceedings of the National Academy of Sciences of the United States of America. 97: 5095-100. PMID 10805772 DOI: 10.1073/Pnas.97.10.5095  0.674
2000 Shen JC, Loeb LA. The Werner syndrome gene: the molecular basis of RecQ helicase-deficiency diseases. Trends in Genetics : Tig. 16: 213-20. PMID 10782115 DOI: 10.1016/S0168-9525(99)01970-8  0.472
2000 Kamath-Loeb AS, Johansson E, Burgers PM, Loeb LA. Functional interaction between the Werner Syndrome protein and DNA polymerase delta. Proceedings of the National Academy of Sciences of the United States of America. 97: 4603-8. PMID 10781066 DOI: 10.1073/Pnas.97.9.4603  0.481
2000 Jackson AL, Loeb LA. Microsatellite instability induced by hydrogen peroxide in Escherichia coli. Mutation Research. 447: 187-98. PMID 10751602 DOI: 10.1016/S0027-5107(99)00206-7  0.46
2000 Loeb KR, Loeb LA. Significance of multiple mutations in cancer. Carcinogenesis. 21: 379-85. PMID 10688858 DOI: 10.1093/Carcin/21.3.379  0.497
2000 Loeb LA, Mullins JI. Lethal mutagenesis of HIV by mutagenic ribonucleoside analogs. Aids Research and Human Retroviruses. 16: 1-3. PMID 10628810 DOI: 10.1089/088922200309539  0.312
1999 Abril N, Luque-Romero FL, Christians FC, Encell LP, Loeb LA, Pueyo C. Human O(6)-alkylguanine-DNA alkyltransferase: protection against alkylating agents and sensitization to dibromoalkanes. Carcinogenesis. 20: 2089-94. PMID 10545410 DOI: 10.1093/Carcin/20.11.2089  0.411
1999 Encell LP, Loeb LA. Redesigning the substrate specificity of human O(6)-alkylguanine-DNA alkyltransferase. Mutants with enhanced repair of O(4)-methylthymine. Biochemistry. 38: 12097-103. PMID 10508414 DOI: 10.1021/Bi9913606  0.351
1999 Landis DM, Gerlach JL, Adman ET, Loeb LA. Tolerance of 5-fluorodeoxyuridine resistant human thymidylate synthases to alterations in active site residues. Nucleic Acids Research. 27: 3702-11. PMID 10471740 DOI: 10.1093/Nar/27.18.3702  0.313
1999 Loeb KR, Loeb LA. Genetic instability and the mutator phenotype. Studies in ulcerative colitis. The American Journal of Pathology. 154: 1621-6. PMID 10362784 DOI: 10.1016/S0002-9440(10)65415-6  0.466
1999 Newcomb TG, Allen KJ, Tkeshelashvili L, Loeb LA. Detection of tandem CC-->TT mutations induced by oxygen radicals using mutation-specific PCR. Mutation Research. 427: 21-30. PMID 10354498 DOI: 10.1016/S0027-5107(99)00075-5  0.501
1999 Fry M, Loeb LA. Human werner syndrome DNA helicase unwinds tetrahelical structures of the fragile X syndrome repeat sequence d(CGG)n. The Journal of Biological Chemistry. 274: 12797-802. PMID 10212265 DOI: 10.1074/Jbc.274.18.12797  0.375
1999 Encell LP, Landis DM, Loeb LA. Improving enzymes for cancer gene therapy. Nature Biotechnology. 17: 143-7. PMID 10052349 DOI: 10.1038/6142  0.353
1999 Loeb LA, Essigmann JM, Kazazi F, Zhang J, Rose KD, Mullins JI. Lethal mutagenesis of HIV with mutagenic nucleoside analogs. Proceedings of the National Academy of Sciences of the United States of America. 96: 1492-7. PMID 9990051 DOI: 10.1073/Pnas.96.4.1492  0.374
1998 Jackson AL, Loeb LA. On the origin of multiple mutations in human cancers. Seminars in Cancer Biology. 8: 421-9. PMID 10191176 DOI: 10.1006/Scbi.1998.0113  0.428
1998 Kamath-Loeb AS, Shen JC, Loeb LA, Fry M. Werner syndrome protein: II. Characterization of the integral 3' → 5' DNA exonuclease Journal of Biological Chemistry. 273: 34145-34150. PMID 9852074 DOI: 10.1074/Jbc.273.51.34145  0.47
1998 Shen JC, Gray MD, Oshima J, Kamath-Loeb AS, Fry M, Loeb LA. Werner syndrome protein: I. DNA helicase and DNA exonuclease reside on the same polypeptide Journal of Biological Chemistry. 273: 34139-34144. PMID 9852073 DOI: 10.1074/Jbc.273.51.34139  0.442
1998 Jackson AL, Chen R, Loeb LA. Induction of microsatellite instability by oxidative DNA damage Proceedings of the National Academy of Sciences of the United States of America. 95: 12468-12473. PMID 9770509 DOI: 10.1073/Pnas.95.21.12468  0.478
1998 Rink SM, Shen JC, Loeb LA. Creation of RNA molecules that recognize the oxidative lesion 7,8- dihydro-8-hydroxy-2'-deoxyguanosine (8-oxodG) in DNA Proceedings of the National Academy of Sciences of the United States of America. 95: 11619-11624. PMID 9751715 DOI: 10.1073/Pnas.95.20.11619  0.398
1998 Landis DM, Loeb LA. Random sequence mutagenesis and resistance to 5-fluorouridine in human thymidylate synthases. The Journal of Biological Chemistry. 273: 25809-17. PMID 9748254 DOI: 10.1074/Jbc.273.40.25809  0.371
1998 Fry M, Loeb LA. The three faces of the WS helicase Nature Genetics. 19: 308-309. PMID 9697682 DOI: 10.1038/1188  0.375
1998 Shen JC, Gray MD, Oshima J, Loeb LA. Characterization of Werner syndrome protein DNA helicase activity: Directionality, substrate dependence and stimulation by replication protein A Nucleic Acids Research. 26: 2879-2885. PMID 9611231 DOI: 10.1093/Nar/26.12.2879  0.454
1998 Jackson AL, Newcomb TG, Loeb LA. Origin of multiple mutations in human cancers Drug Metabolism Reviews. 30: 285-304. PMID 9606605 DOI: 10.3109/03602539808996313  0.383
1998 Jackson AL, Loeb LA. The mutation rate and cancer Genetics. 148: 1483-1490. PMID 9560368  0.344
1998 Kim B, Hathaway TR, Loeb LA. Fidelity of mutant HIV-1 reverse transcriptases: Interaction with the single-stranded template influences the accuracy of DNA synthesis Biochemistry. 37: 5831-5839. PMID 9558316 DOI: 10.1021/Bi972672G  0.462
1998 Encell LP, Coates MM, Loeb LA. Engineering human DNA alkyltransferases for gene therapy using random sequence mutagenesis. Cancer Research. 58: 1013-20. PMID 9500464  0.309
1997 Kamath-Loeb AS, Hizi A, Tabone J, Solomon MS, Loeb LA. Inefficient repair of-RNA · DNA hybrids European Journal of Biochemistry. 250: 492-501. PMID 9428703 DOI: 10.1111/J.1432-1033.1997.0492A.X  0.451
1997 Loeb LA. Cancer cells exhibit a mutator phenotype Advances in Cancer Research. 72: 24-56. PMID 9338073 DOI: 10.1016/S0065-230X(08)60699-5  0.426
1997 Loeb LA. Transient expression of a mutator phenotype in cancer cells Science. 277: 1449-1450. PMID 9304215 DOI: 10.1126/Science.277.5331.1449  0.446
1997 Gray MD, Shen JC, Kamath-Loeb AS, Blank A, Sopher BL, Martin GM, Oshima J, Loeb LA. The Werner syndrome protein is a DNA helicase Nature Genetics. 17: 100-103. PMID 9288107 DOI: 10.1038/Ng0997-100  0.416
1997 Suzuki M, Avicola AK, Hood L, Loeb LA. Low fidelity mutants in the O-helix of Thermus aquaticus DNA polymerase I Journal of Biological Chemistry. 272: 11228-11235. PMID 9111024 DOI: 10.1074/Jbc.272.17.11228  0.477
1997 Hizi A, Kamath-Loeb AS, Rose KD, Loeb LA. Mutagenesis by human immunodeficiency virus reverse transcriptase: incorporation of O6-methyldeoxyguanosine triphosphate. Mutation Research. 374: 41-50. PMID 9067414 DOI: 10.1016/S0027-5107(96)00217-5  0.413
1997 Kamath-Loeb AS, Hizi A, Kasai H, Loeb LA. Incorporation of the guanosine triphosphate analogs 8-oxo-dGTP and 8- NH2-dGTP by reverse transcriptases and mammalian DNA polymerases Journal of Biological Chemistry. 272: 5892-5898. PMID 9038207 DOI: 10.1074/Jbc.272.9.5892  0.427
1997 Cheng KC, Loeb LA. Genomic stability and instability: A working paradigm Current Topics in Microbiology and Immunology. 221: 5-18. PMID 8979437 DOI: 10.1007/978-3-642-60505-5_2  0.69
1997 Encell L, Christians F, Coates M, Loeb LA. O III A.1 Creation of new mutant DNA repair enzymes Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 379: S17. DOI: 10.1016/S0027-5107(97)82647-4  0.398
1997 Kamath-Loeb AS, Hizi A, Loeb LA. Resistance of the DNA strand in RNA-DNA hybrids to DNA repair Faseb Journal. 11: A1369.  0.34
1996 Loeb LA. Unnatural Nucleotide Sequences in Biopharmaceutics Advances in Pharmacology. 35: 321-347. PMID 8920210 DOI: 10.1016/S1054-3589(08)60280-X  0.402
1996 Suzuki M, Baskin D, Hood L, Loeb LA. Random mutagenesis of Thermus aquaticus DNA polymerase I: Concordance of immutable sites in vivo with the crystal structure Proceedings of the National Academy of Sciences of the United States of America. 93: 9670-9675. PMID 8790389 DOI: 10.1073/Pnas.93.18.9670  0.434
1996 Ji J, Clegg NJ, Peterson KR, Jackson AL, Laird CD, Loeb LA. In vitro expansion of GGC:GCC repeats: identification of the preferred strand of expansion. Nucleic Acids Research. 24: 2835-40. PMID 8759019 DOI: 10.1093/Nar/24.14.2835  0.481
1996 Loeb LA, Christians FC. Multiple mutations in human cancers Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 350: 279-286. PMID 8657192 DOI: 10.1016/0027-5107(95)00117-4  0.412
1996 Christians FC, Loeb LA. Novel human DNA alkyltransferases obtained by random substitution and genetic selection in bacteria Proceedings of the National Academy of Sciences of the United States of America. 93: 6124-6128. PMID 8650230 DOI: 10.1073/Pnas.93.12.6124  0.456
1996 Black ME, Newcomb TG, Wilson HMP, Loeb LA. Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy Proceedings of the National Academy of Sciences of the United States of America. 93: 3525-3529. PMID 8622970 DOI: 10.1073/Pnas.93.8.3525  0.307
1996 Kim B, Hathaway TR, Loeb LA. Human immunodeficiency virus reverse transcriptase: Functional mutants obtained by random mutagenesis coupled with genetic selection in Escherichia coli Journal of Biological Chemistry. 271: 4872-4878. PMID 8617758 DOI: 10.1074/Jbc.271.9.4872  0.47
1996 Loeb LA, Newcomb T, Jackson A, Rink S. Oxidants and multiple mutations in cancer Biochemical Society Transactions. 24: 522S. DOI: 10.1042/Bst024522Sb  0.353
1995 Christians FC, Connolly D, Tsuchiya K, True LD, Loeb LA. Lack of microsatellite instability in human prostate-cancer. International Journal of Oncology. 6: 1173-1176. PMID 21556654 DOI: 10.3892/Ijo.6.6.1173  0.35
1995 Reid TM, Feig DI, Loeb LA. Mutagenesis by metal-induced oxygen radicals. Environmental Health Perspectives. 57-61. PMID 7843138 DOI: 10.1289/Ehp.94102S357  0.442
1995 Sweasy JB, Chen M, Loeb LA. DNA polymerase β can substitute for DNA polymerase I in the initiation of plasmid DNA replication Journal of Bacteriology. 177: 2923-2925. PMID 7751308 DOI: 10.1128/Jb.177.10.2923-2925.1995  0.369
1995 Kim B, Loeb LA. Human immunodeficiency virus reverse transcriptase substitutes for DNA polymerase I in Escherichia coli Proceedings of the National Academy of Sciences of the United States of America. 92: 684-688. PMID 7531338 DOI: 10.1073/Pnas.92.3.684  0.373
1995 Christians FC, Newcomb TG, Loeb LA. Potential Sources of Multiple Mutations in Human Cancers Preventive Medicine. 24: 329-332. PMID 7479621 DOI: 10.1006/Pmed.1995.1054  0.415
1994 Feig DI, Loeb LA. Oxygen radical induced mutagenesis is DNA polymerase specific. Journal of Molecular Biology. 235: 33-41. PMID 8289253 DOI: 10.1016/S0022-2836(05)80009-9  0.497
1994 Chang M, Burmer GC, Sweasy J, Loeb LA, Edelhoff S, Disteche CM, Yu CE, Anderson L, Oshima J, Nakura J. Evidence against DNA polymerase beta as a candidate gene for Werner syndrome. Human Genetics. 93: 507-12. PMID 8168825 DOI: 10.1007/Bf00202813  0.488
1994 Munir KM, French DC, Dube DK, Loeb LA. Herpes thymidine kinase mutants with altered catalytic efficiencies obtained by random sequence selection. Protein Engineering. 7: 83-9. PMID 8140098 DOI: 10.1093/Protein/7.1.83  0.341
1994 Blank A, Kim B, Loeb LA. DNA polymerase δ is required for base excision repair of DNA methylation damage in Saccharomyces cerevisiae Proceedings of the National Academy of Sciences of the United States of America. 91: 9047-9051. PMID 8090767 DOI: 10.1073/Pnas.91.19.9047  0.467
1994 Beckman RA, Loeb LA. Multi-stage proofreading in DNA replication. Quarterly Reviews of Biophysics. 26: 225-331. PMID 8022969 DOI: 10.1017/S0033583500002869  0.452
1994 Feig DI, Sowers LC, Loeb LA. Reverse chemical mutagenesis: Identification of the mutagenic lesions resulting from reactive oxygen species-mediated damage to DNA Proceedings of the National Academy of Sciences of the United States of America. 91: 6609-6613. PMID 7517554 DOI: 10.1073/Pnas.91.14.6609  0.456
1994 Ji J, Hoffmann JS, Loeb L. Mutagenicity and pausing of HIV reverse transcriptase during HIV plus-strand DNA synthesis Nucleic Acids Research. 22: 47-52. PMID 7510388 DOI: 10.1093/Nar/22.1.47  0.373
1994 Ji J, Loeb LA. Fidelity of HIV-1 Reverse Transcriptase Copying a Hypervariable Region of the HIV-1 env Gene Virology. 199: 323-330. PMID 7510083 DOI: 10.1006/Viro.1994.1130  0.349
1993 Sweasy JB, Loeb LA. Detection and characterization of mammalian DNA polymerase beta mutants by functional complementation in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 90: 4626-30. PMID 8506308 DOI: 10.1073/Pnas.90.10.4626  0.475
1993 Reid TM, Loeb LA. Tandem double CC-->TT mutations are produced by reactive oxygen species. Proceedings of the National Academy of Sciences of the United States of America. 90: 3904-7. PMID 8483909 DOI: 10.1073/Pnas.90.9.3904  0.481
1993 Feig DI, Loeb LA. Mechanisms of mutation by oxidative DNA damage: reduced fidelity of mammalian DNA polymerase beta. Biochemistry. 32: 4466-73. PMID 8476871 DOI: 10.1021/Bi00067A040  0.513
1993 Cheng KC, Loeb LA. Genomic instability and tumor progression: mechanistic considerations. Advances in Cancer Research. 60: 121-56. PMID 8417498 DOI: 10.1016/S0065-230X(08)60824-6  0.64
1993 Munir KM, French DC, Loeb LA. Thymidine kinase mutants obtained by random sequence selection. Proceedings of the National Academy of Sciences of the United States of America. 90: 4012-6. PMID 8387207 DOI: 10.1073/Pnas.90.9.4012  0.354
1993 Dube DK, Black ME, Munir KM, Loeb LA. Selection of new biologically active molecules from random nucleotide sequences Gene. 137: 41-47. PMID 8282199 DOI: 10.1016/0378-1119(93)90249-3  0.407
1993 Reid TM, Loeb LA. Effect of DNA-repair enzymes on mutagenesis by oxygen free radicals. Mutation Research. 289: 181-6. PMID 7690886 DOI: 10.1016/0027-5107(93)90068-Q  0.431
1992 Burmer GC, Rabinovitch PS, Loeb LA. Frequency and spectrum of c-Ki-ras mutations in human sporadic colon carcinoma, carcinomas arising in ulcerative colitis, and pancreatic adenocarcinoma. Environmental Health Perspectives. 93: 27-31. PMID 1773797 DOI: 10.1289/Ehp.919327  0.373
1992 Fry M, Loeb LA. A DNA polymerase alpha pause site is a hot spot for nucleotide misinsertion. Proceedings of the National Academy of Sciences of the United States of America. 89: 763-7. PMID 1731352 DOI: 10.1073/Pnas.89.2.763  0.409
1992 Dube DK, Parker JD, French DC, Cahill DS, Dube S, Horwitz MS, Munir KM, Loeb LA. Artificial mutants generated by the insertion of random oligonucleotides into the putative nucleoside binding site of the HSV-1 thymidine kinase gene. Biochemistry. 30: 11760-7. PMID 1661147 DOI: 10.1021/Bi00115A004  0.344
1992 McBride TJ, Schneider JE, Floyd RA, Loeb LA. Mutations induced by methylene blue plus light in single-stranded M13mp2. Proceedings of the National Academy of Sciences of the United States of America. 89: 6866-70. PMID 1495976 DOI: 10.1073/Pnas.89.15.6866  0.491
1992 Rao KS, Loeb LA. DNA damage and repair in brain: relationship to aging. Mutation Research. 275: 317-29. PMID 1383773 DOI: 10.1016/0921-8734(92)90035-N  0.405
1992 Williams KJ, Loeb LA. Retroviral reverse transcriptases: Error frequencies and mutagenesis Current Topics in Microbiology and Immunology. 176: 165-180. PMID 1376224 DOI: 10.1007/978-3-642-77011-1_11  0.319
1992 Ji J, Loeb LA. Fidelity of HIV-1 reverse transcriptase copying RNA in vitro Biochemistry. 31: 954-958. PMID 1370910 DOI: 10.1021/Bi00119A002  0.419
1991 Cheng KC, Preston BD, Cahill DS, Dosanjh MK, Singer B, Loeb LA. The vinyl chloride DNA derivative N2,3-ethenoguanine produces G → A transitions in Escherichia coli Proceedings of the National Academy of Sciences of the United States of America. 88: 9974-9978. PMID 1946466 DOI: 10.1073/Pnas.88.22.9974  0.721
1991 Dube DK, Horwitz MS, Loeb LA. The association of thymidine kinase activity and thymidine transport in Escherichia coli. Gene. 99: 25-9. PMID 1850708 DOI: 10.1016/0378-1119(91)90029-B  0.335
1991 McBride TJ, Preston BD, Loeb LA. Mutagenic spectrum resulting from DNA damage by oxygen radicals. Biochemistry. 30: 207-13. PMID 1703014 DOI: 10.1021/Bi00215A030  0.472
1990 Horwitz MS, Dube DK, Loeb LA. Selection of new biological activities from random nucleotide sequences: evolutionary and practical considerations. Genome. 31: 112-7. PMID 2687088 DOI: 10.1139/G89-021  0.405
1990 Loeb LA, Cheng KC. Errors in DNA synthesis: a source of spontaneous mutations. Mutation Research. 238: 297-304. PMID 2188126 DOI: 10.1016/0165-1110(90)90021-3  0.733
1990 Horwitz MS, Loeb LA. Structure-function relationships in Escherichia coli promoter DNA. Progress in Nucleic Acid Research and Molecular Biology. 38: 137-64. PMID 2183292 DOI: 10.1016/S0079-6603(08)60710-2  0.412
1990 Perrino FW, Loeb LA. Hydrolysis of 3′-terminal mispairs in vitro by the 3′ → 5′ exonuclease of DNA polymerase δ permits subsequent extension by DNA polymerase α Biochemistry. 29: 5226-5231. PMID 2166556 DOI: 10.1021/Bi00474A002  0.452
1990 Perrino FW, Loeb LA. Animal cell DNA polymerases in DNA repair Mutation Research-Dna Repair. 236: 289-300. PMID 2119003 DOI: 10.1016/0921-8777(90)90012-T  0.451
1989 Dube DK, Loeb LA. Mutants generated by the insertion of random oligonucleotides into the active site of the β-lactamase gene Biochemistry. 28: 5703-5707. PMID 2789078 DOI: 10.1021/Bi00440A001  0.357
1989 Weisman-Shomer P, Dube DK, Perrino FW, Stokes K, Loeb LA, Fry M. Sequence specificity of pausing by DNA polymerases. Biochemical and Biophysical Research Communications. 164: 1149-56. PMID 2686635 DOI: 10.1016/0006-291X(89)91789-0  0.47
1989 Burmer GC, Loeb LA. Mutations in the KRAS2 oncogene during progressive stages of human colon carcinoma. Proceedings of the National Academy of Sciences of the United States of America. 86: 2403-7. PMID 2648401 DOI: 10.1073/Pnas.86.7.2403  0.443
1989 Perrino FW, Loeb LA. Proofreading by the ε subunit of Escherichia coli DNA polymerase III increases the fidelity of calf thymus DNA polymerase α Proceedings of the National Academy of Sciences of the United States of America. 86: 3085-3088. PMID 2524067 DOI: 10.1073/Pnas.86.9.3085  0.442
1989 Perrino FW, Preston BD, Sandell LL, Loeb LA. Extension of mismatched 3' termini of DNA is a major determinant of the infidelity of human immunodeficiency virus type 1 reverse transcriptase Proceedings of the National Academy of Sciences of the United States of America. 86: 8343-8347. PMID 2479023 DOI: 10.1073/Pnas.86.21.8343  0.432
1989 Roberts JD, Preston BD, Johnston LA, Soni A, Loeb LA, Kunkel TA. Fidelity of two retroviral reverse transcriptases during DNA-dependent DNA synthesis in vitro. Molecular and Cellular Biology. 9: 469-76. PMID 2469002 DOI: 10.1128/Mcb.9.2.469  0.444
1988 Preston BD, Loeb LA. Enzymatic synthesis of site-specifically modified DNA Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 200: 21-35. PMID 3393161 DOI: 10.1016/0027-5107(88)90068-1  0.417
1988 Mita S, Monnat RJ, Loeb LA. Direct selection of mutations in the human mitochondrial tRNAThr gene: reversion of an 'uncloneable' phenotype Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 199: 183-190. PMID 3362158 DOI: 10.1016/0027-5107(88)90244-8  0.447
1988 Fry M, Perrino FW, Levy A, Loeb LA. Factor D is a selective single-stranded oligodeoxythymidine binding protein Nucleic Acids Research. 16: 199-211. PMID 3340524 DOI: 10.1093/Nar/16.1.199  0.325
1988 Preston BD, Poiesz BJ, Loeb LA. Fidelity of HIV-1 reverse transcriptase Science. 242: 1168-1171. PMID 2460924 DOI: 10.1126/Science.2460924  0.306
1988 Loeb LA, James EA, Waltersdorph AM, Klebanoff SJ. Mutagenesis by the autoxidation of iron with isolated DNA. Proceedings of the National Academy of Sciences of the United States of America. 85: 3918-22. PMID 2453880 DOI: 10.1073/Pnas.85.11.3918  0.424
1987 Cotterill SM, Reyland ME, Loeb LA, Lehman IR. A cryptic proofreading 3'----5' exonuclease associated with the polymerase subunit of the DNA polymerase-primase from Drosophila melanogaster. Proceedings of the National Academy of Sciences of the United States of America. 84: 5635-9. PMID 3112771 DOI: 10.1073/Pnas.84.16.5635  0.341
1987 Aizawa S, Loeb LA, Martin GM. Aphidicolin-resistant mutator strains of mouse teratocarcinoma. Molecular & General Genetics : Mgg. 208: 342-8. PMID 3112523 DOI: 10.1007/Bf00330463  0.445
1987 Abbotts J, Nishiyama Y, Yoshida S, Loeb LA. On the fidelity of DNA replication: herpes DNA polymerase and its associated exonuclease. Nucleic Acids Research. 15: 1185-98. PMID 3029700 DOI: 10.1093/Nar/15.3.1185  0.493
1987 Snow ET, Kunkel TA, Loeb LA. Base substitution mutagenesis by terminal transferase: its role in somatic mutagenesis. Mutation Research. 180: 137-46. PMID 2958704 DOI: 10.1016/0027-5107(87)90208-9  0.509
1987 Schaaper RM, Koplitz RM, Tkeshelashvili LK, Loeb LA. Metal-induced lethality and mutagenesis: possible role of apurinic intermediates. Mutation Research. 177: 179-88. PMID 2951593 DOI: 10.1016/0027-5107(87)90001-7  0.628
1986 Loeb LA, Liu PK, Fry M. DNA polymerase-alpha: enzymology, function, fidelity, and mutagenesis. Progress in Nucleic Acid Research and Molecular Biology. 33: 57-110. PMID 3797680 DOI: 10.1016/S0079-6603(08)60020-3  0.465
1986 Loeb LA, Preston BD, Snow ET, Schaaper RM. Apurinic sites as common intermediates in mutagenesis Basic Life Sciences. 38: 341-347. PMID 3741336 DOI: 10.1007/978-1-4615-9462-8_37  0.508
1986 Loeb LA, Preston BD. Mutagenesis by apurinic/apyrimidinic sites Annual Review of Genetics. 20: 201-230. PMID 3545059 DOI: 10.1146/Annurev.Ge.20.120186.001221  0.337
1986 Preston BD, Singer B, Loeb LA. Mutagenic potential of O4-methylthymine in vivo determined by an enzymatic approach to site-specific mutagenesis Proceedings of the National Academy of Sciences of the United States of America. 83: 8501-8505. PMID 3464967 DOI: 10.1073/Pnas.83.22.8501  0.473
1986 Blank A, Gallant JA, Burgess RR, Loeb LA. An RNA polymerase mutant with reduced accuracy of chain elongation Biochemistry. 25: 5920-5928. PMID 3098280 DOI: 10.1021/Bi00368A013  0.371
1986 Kunkel TA, Gopinathan KP, Dube DK, Snow ET, Loeb LA. Rearrangements of DNA mediated by terminal transferase. Proceedings of the National Academy of Sciences of the United States of America. 83: 1867-71. PMID 2937062 DOI: 10.1073/Pnas.83.6.1867  0.501
1985 Beckman RA, Mildvan AS, Loeb LA. On the fidelity of DNA replication: manganese mutagenesis in vitro. Biochemistry. 24: 5810-7. PMID 3910084 DOI: 10.1021/Bi00342A019  0.411
1985 Aizawa S, Ohashi M, Loeb LA, Martin GM. Multipotent mutator strain of mouse teratocarcinoma cells. Somatic Cell and Molecular Genetics. 11: 211-6. PMID 3859019 DOI: 10.1007/Bf01534677  0.382
1985 Subba Rao K, Martin GM, Loeb LA. Fidelity of DNA polymerase-beta in neurons from young and very aged mice. Journal of Neurochemistry. 45: 1273-8. PMID 3161998 DOI: 10.1111/J.1471-4159.1985.Tb05553.X  0.411
1985 Das SK, Kunkel TA, Loeb LA. Effects of altered nucleotide concentrations on the fidelity of DNA replication. Basic Life Sciences. 31: 117-26. PMID 3158301 DOI: 10.1007/978-1-4613-2449-2_7  0.48
1985 Abbotts J, Loeb LA. On the fidelity of DNA replication: use of synthetic oligonucleotide-initiated reactions. Biochimica Et Biophysica Acta. 824: 58-65. PMID 3155626 DOI: 10.1016/0167-4781(85)90029-6  0.455
1985 Abbotts J, Loeb LA. DNA polymerase alpha and models for proofreading. Nucleic Acids Research. 13: 261-74. PMID 2987791 DOI: 10.1093/Nar/13.1.261  0.342
1985 Monnat RJ, Loeb LA. Nucleotide sequence preservation of human mitochondrial DNA Proceedings of the National Academy of Sciences of the United States of America. 82: 2895-2899. PMID 2986144 DOI: 10.1073/Pnas.82.9.2895  0.421
1985 Loeb L. Controversies in the Basic Sciences: Is There an Inducible Error-Prone Pathway in Mammalian Cells That Is Responsible for Mutations by Many Chemical Carcinogens? Cancer Investigation. 3: 161-161. DOI: 10.3109/07357908509017498  0.342
1984 Fry M, Silber J, Loeb LA, Martin GM. Delayed and reduced cell replication and diminishing levels of DNA polymerase-alpha in regenerating liver of aging mice. Journal of Cellular Physiology. 118: 225-32. PMID 6699097 DOI: 10.1002/Jcp.1041180302  0.406
1984 Liu PK, Loeb LA. Transfection of the DNA polymerase-alpha gene. Science (New York, N.Y.). 226: 833-5. PMID 6436977 DOI: 10.1126/Science.6436977  0.436
1984 Zakour RA, James EA, Loeb LA. Site specific mutagenesis: insertion of single noncomplementary nucleotides at specified sites by error-directed DNA polymerization. Nucleic Acids Research. 12: 6615-28. PMID 6089123 DOI: 10.1093/Nar/12.16.6615  0.476
1983 Aizawa S, Loeb LA, Martin GM. Mouse teratocarcinoma cells resistant to aphidicolin and arabinofuranosyl cytosine: isolation and initial characterization. Journal of Cellular Physiology. 115: 9-14. PMID 6403560 DOI: 10.1002/Jcp.1041150103  0.351
1983 Liu PK, Chang CC, Trosko JE, Dube DK, Martin GM, Loeb LA. Mammalian mutator mutant with an aphidicolin-resistant DNA polymerase alpha. Proceedings of the National Academy of Sciences of the United States of America. 80: 797-801. PMID 6402775 DOI: 10.1073/Pnas.80.3.797  0.453
1983 Kunkel TA, Schaaper RM, Loeb LA. Depurination-induced infidelity of deoxyribonucleic acid synthesis with purified deoxyribonucleic acid replication proteins in vitro. Biochemistry. 22: 2378-84. PMID 6344919 DOI: 10.1021/Bi00279A012  0.502
1983 Ferrin LJ, Mildvan AS, Loeb LA. Metal content of DNA polymerase I purified from overproducing and wild type Escherichia coli. Biochemical and Biophysical Research Communications. 112: 723-8. PMID 6342619 DOI: 10.1016/0006-291X(83)91522-X  0.371
1983 Schaaper RM, Kunkel TA, Loeb LA. Infidelity of DNA synthesis associated with bypass of apurinic sites. Proceedings of the National Academy of Sciences of the United States of America. 80: 487-91. PMID 6300848 DOI: 10.1073/Pnas.80.2.487  0.484
1983 Kunkel TA, Schaaper RM, James E, Loeb LA. Infidelity of DNA replication as a basis of mutagenesis. Basic Life Sciences. 23: 63-82. PMID 6220695 DOI: 10.1007/978-1-4684-4382-0_3  0.534
1983 Schaaper RM, Glickman BW, Loeb LA. Mutagenesis resulting from depurination is an SOS process. Mutation Research. 106: 1-9. PMID 6219285 DOI: 10.1016/0027-5107(82)90186-5  0.361
1982 Schaaper RM, Kunkel TA, Loeb LA. Depurination of DNA as a possible mutagenic pathway for cells. Basic Life Sciences. 20: 199-211. PMID 7052053 DOI: 10.1007/978-1-4613-3476-7_12  0.487
1982 Zakour RA, Loeb LA. Site-specific mutagenesis by error-directed DNA synthesis. Nature. 295: 708-10. PMID 6460194 DOI: 10.1038/295708A0  0.489
1982 Silber JR, Loeb LA. S1 nuclease does not cleave DNA at single-base mis-matches. Biochimica Et Biophysica Acta. 656: 256-64. PMID 6274410 DOI: 10.1016/0005-2787(81)90094-0  0.394
1982 Loeb LA, Kunkel TA. Fidelity of DNA synthesis. Annual Review of Biochemistry. 51: 429-57. PMID 6214209 DOI: 10.1146/Annurev.Bi.51.070182.002241  0.436
1982 Kunkel TA, Silber JR, Loeb LA. The mutagenic effect of deoxynucleotide substrate imbalances during DNA synthesis with mammalian DNA polymerases. Mutation Research. 94: 413-9. PMID 6213856 DOI: 10.1016/0027-5107(82)90304-9  0.507
1981 Zakour RA, Kunkel TA, Loeb LA. Metal-induced infidelity of DNA synthesis. Environmental Health Perspectives. 40: 197-205. PMID 7274184 DOI: 10.1289/Ehp.8140197  0.382
1981 Zakour RA, Tkeshelashvili LK, Shearman CW, Koplitz RM, Loeb LA. Metal-induced infidelity of DNA synthesis. Journal of Cancer Research and Clinical Oncology. 99: 187-96. PMID 7251634 DOI: 10.1007/Bf00412453  0.404
1981 Fry M, Loeb LA, Martin GM. On the activity and fidelity of chromatin-associated hepatic DNA polymerase-β in aging murine species of different life spans Journal of Cellular Physiology. 106: 435-444. PMID 7217221 DOI: 10.1002/Jcp.1041060313  0.407
1981 Kunkel TA, Eckstein F, Mildvan AS, Koplitz RM, Loeb LA. Deoxynucleoside [1-thio]triphosphates prevent proofreading during in vitro DNA synthesis Proceedings of the National Academy of Sciences of the United States of America. 78: 6734-6738. PMID 6458818 DOI: 10.1073/Pnas.78.11.6734  0.482
1981 Kunkel TA, Loeb LA. Fidelity of mammalian DNA polymerases. Science (New York, N.Y.). 213: 765-7. PMID 6454965 DOI: 10.1126/Science.6454965  0.469
1981 Schaaper RM, Loeb LA. Depurination causes mutations in SOS-induced cells. Proceedings of the National Academy of Sciences of the United States of America. 78: 1773-7. PMID 6453349 DOI: 10.1073/Pnas.78.3.1773  0.478
1981 Kunkel TA, Shearman CW, Loeb LA. Mutagenesis in vitro by depurination of phiX174 dna. Nature. 291: 349-51. PMID 6453298 DOI: 10.1038/291349A0  0.442
1981 Fry M, Shearman CW, Martin GM, Loeb LA. On the fidelity of deoxyribonucleic acid synthesis directed by chromatin-associated deoxyribonucleic acid polymerase beta. Biochemistry. 19: 5939-46. PMID 6257296 DOI: 10.1021/Bi00566A043  0.396
1980 Sirover MA, Loeb LA. On the fidelity of DNA synthesis: Effects of steroids and intercalating agents Chemico-Biological Interactions. 30: 1-8. PMID 7379201 DOI: 10.1016/0009-2797(80)90109-X  0.435
1980 Kunkel TA, Meyer RR, Loeb LA. Single-strand binding protein enhances fidelity of DNA synthesis in vitro. Proceedings of the National Academy of Sciences of the United States of America. 76: 6331-5. PMID 230506 DOI: 10.1073/Pnas.76.12.6331  0.427
1979 Shearman CW, Loeb LA. Effects of depurination on the fidelity of DNA synthesis. Journal of Molecular Biology. 128: 197-218. PMID 430573 DOI: 10.1016/0022-2836(79)90126-8  0.435
1979 Dube DK, Kunkel TA, Seal G, Loeb LA. Distinctive properties of mammalian DNA polymerases. Biochimica Et Biophysica Acta. 561: 369-82. PMID 284807 DOI: 10.1016/0005-2787(79)90145-X  0.419
1979 Gopinathan KP, Weymouth LA, Kunkel TA, Loeb LA. Mutagenesis in vitro by DNA polymerase from an RNA tumour virus. Nature. 278: 857-9. PMID 220540 DOI: 10.1038/278857A0  0.491
1979 Loeb LA, Weymouth LA, Kunkel TA, Gopinathan KP, Beckman RA, Dube DK. On the fidelity of DNA replication. Cold Spring Harbor Symposia On Quantitative Biology. 43: 921-7. PMID 90579 DOI: 10.1101/Sqb.1979.043.01.101  0.457
1978 Agarwal SS, Tuffner M, Loeb LA. DNA replication in human lymphocytes during aging Journal of Cellular Physiology. 96: 235-243. PMID 670307 DOI: 10.1002/Jcp.1040960212  0.399
1978 Dube DK, Travaglini EC, Loeb LA. Isolation and characterization of DNA polymerases from eukaryotic cells. Methods in Cell Biology. 19: 27-42. PMID 357914 DOI: 10.1016/S0091-679X(08)60007-2  0.315
1978 Weymouth LA, Loeb LA. Mutagenesis during in vitro DNA synthesis. Proceedings of the National Academy of Sciences of the United States of America. 75: 1924-8. PMID 347450 DOI: 10.1073/Pnas.75.4.1924  0.503
1977 Loeb LA, Sirover MA, Agarwal SS. Infidelity of DNA synthesis as related to mutagenesis and carcinogenesis Advances in Experimental Medicine and Biology. 91: 103-115. PMID 605848 DOI: 10.1007/978-1-4684-0796-9_8  0.481
1977 Shearman CW, Loeb LA. Depurination decreases fidelity of DNA synthesis in vitro Nature. 270: 537-538. PMID 593377 DOI: 10.1038/270537A0  0.477
1977 Weymouth LA, Loeb LA. Infidelity of DNA synthesis by themperature-sensitive DNA polymerases from RNA tumor viruses. Biochimica Et Biophysica Acta. 478: 305-15. PMID 199256 DOI: 10.1016/0005-2787(77)90148-4  0.461
1977 Dube DK, Seal G, Loeb LA. Differential heat sensitivity of mammalian DNA polymerases. Biochemical and Biophysical Research Communications. 76: 483-7. PMID 194602 DOI: 10.1016/0006-291X(77)90750-1  0.425
1977 Travaglini EC, Dube DK, Surrey S, Loeb LA. Template recognition and chain elongation in DNA synthesis in vitro. Journal of Molecular Biology. 106: 605-21. PMID 185394 DOI: 10.1016/0022-2836(76)90254-0  0.452
1977 Loeb LA, Agarwal SS, Dube DK, Gopinathan KP, Travaglini EC, Seal G, Sirover MA. Inhibitors of mammalian DNA polymerases: Possible chemotherapeutic approaches Pharmacology and Therapeutics, Part a: Chemotherapy, Toxicology And. 2: 171-193. DOI: 10.1016/0362-5478(77)90013-4  0.413
1976 Sirover MA, Loeb LA. Metal induced infidelity during DNA synthesis Proceedings of the National Academy of Sciences of the United States of America. 73: 2331-2335. PMID 1065882 DOI: 10.1073/Pnas.73.7.2331  0.469
1976 Sirover MA, Loeb LA. Infidelity of DNA synthesis in vitro: Screening for potential metal mutagens of carcinogens Science. 194: 1434-1436. PMID 1006310 DOI: 10.1126/Science.1006310  0.338
1976 Sirover MA, Loeb LA. Metal activation of DNA synthesis Biochemical and Biophysical Research Communications. 70: 812-817. PMID 779784 DOI: 10.1016/0006-291X(76)90664-1  0.442
1976 Dube DK, Loeb LA. On the association of reverse transcriptase with polynucleotide templates during catalysis. Biochemistry. 15: 3605-11. PMID 60129 DOI: 10.1021/Bi00661A031  0.384
1975 Poiesz BJ, Seal G, Loeb LA. Reverse transcriptase: correlation of zinc content with activity. Proceedings of the National Academy of Sciences of the United States of America. 71: 4892-6. PMID 4140513 DOI: 10.1073/Pnas.71.12.4892  0.432
1975 Dube DK, Loeb LA. Manganese as a mutagenic agent during in vitro DNA synthesis Biochemical and Biophysical Research Communications. 67: 1041-1046. PMID 173332 DOI: 10.1016/0006-291X(75)90779-2  0.444
1974 Fansler BS, Loeb LA. Sea urchin nuclear DNA polymerase. Methods in Enzymology. 29: 53-70. PMID 4859478 DOI: 10.1016/0076-6879(74)29009-8  0.416
1974 Williams RO, Loeb LA. Zinc requirement for DNA replication in stimulated human lymphocytes. The Journal of Cell Biology. 58: 594-601. PMID 4747918 DOI: 10.1083/Jcb.58.3.594  0.316
1974 Sirover MA, Loeb LA. Erroneous base-pairing induced by a chemical carcinogen during DNA synthesis Nature. 252: 414-416. PMID 4431466 DOI: 10.1038/252414A0  0.466
1974 Sirover MA, Loeb LA. Infidelity of DNA synthesis: A general property of RNA tumor viruses Biochemical and Biophysical Research Communications. 61: 410-414. PMID 4375985 DOI: 10.1016/0006-291X(74)90972-3  0.393
1974 Poiesz BJ, Battula N, Loeb LA. Zinc in reverse transcriptase. Biochemical and Biophysical Research Communications. 56: 959-64. PMID 4133183 DOI: 10.1016/S0006-291X(74)80282-2  0.305
1973 Fansler B, Loeb LA. Sea urchin nuclear DNA polymerase. IV. Reversible association of DNA polymerase with nuclei during the cell cycle. Experimental Cell Research. 75: 433-41. PMID 4644251 DOI: 10.1016/0014-4827(72)90450-8  0.451
1973 Loeb LA, Tartof KD, Travaglini EC. Copying natural RNAs with E. coli DNA polymerase I. Nature: New Biology. 242: 66-9. PMID 4633264 DOI: 10.1038/Newbio242066A0  0.399
1973 Springgate CF, Loeb LA. Mutagenic DNA polymerase in human leukemic cells. Proceedings of the National Academy of Sciences of the United States of America. 70: 245-9. PMID 4346035 DOI: 10.1073/Pnas.70.1.245  0.418
1973 Loeb LA, Williams RO, Sutnick AI, O'Connell A, Millman I. DNA polymerase activity in human serum: studies with Australia Antigen. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 143: 519-25. PMID 4267773 DOI: 10.3181/00379727-143-37356  0.416
1973 Cohen LH, Penner PE, Loeb LA. Multiple DNA polymerases displayed by isoelectric focusing Annals of the New York Academy of Sciences. 354-362. PMID 4197638 DOI: 10.1111/J.1749-6632.1973.Tb47539.X  0.413
1973 Springgate CF, Battula N, Loeb LA. Infidelity of DNA synthesis by reverse transcriptase. Biochemical and Biophysical Research Communications. 52: 401-6. PMID 4123058 DOI: 10.1016/0006-291X(73)90725-0  0.399
1972 Slater JP, Mildvan AS, Loeb LA. Zinc in DNA polymerases. Biochemical and Biophysical Research Communications. 44: 37-43. PMID 4940372 DOI: 10.1016/S0006-291X(71)80155-9  0.421
1971 Loeb LA, Agarwal SS. DNA polymerase. Correlation with DNA replication during transformation of human lymphocytes Experimental Cell Research. 66: 299-304. PMID 5556427 DOI: 10.1016/0014-4827(71)90681-1  0.463
1971 Penner PE, Cohen LH, Loeb LA. RNA-dependent DNA polymerase: Presence in normal human cells Biochemical and Biophysical Research Communications. 42: 1228-1234. PMID 5550810 DOI: 10.1016/0006-291X(71)90037-4  0.379
1971 Loeb LA, Fansler B. Intracellular migration of DNA polymerase in early developing sea urchin embryos. Biochimica Et Biophysica Acta. 217: 50-5. PMID 5505335 DOI: 10.1016/0005-2787(70)90121-8  0.37
1971 Penner PE, Cohen LH, Loeb LA. RNA-dependent DNA polymerase in human lymphocytes during gene activation by phytohaemagglutinin Nature: New Biology. 232: 58-61. PMID 5284453 DOI: 10.1038/Newbio232058A0  0.406
1971 Agarwal SS, Blumberg BS, Gerstley BJ, London WT, Millman I, Sutnick AI, Loeb LA. Lymphocyte transformation and hepatitis. I. Impairment of thymidine incorporation and DNA polymerase activity. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 137: 1498-502. PMID 5138480 DOI: 10.3181/00379727-137-35818  0.412
1971 Fansler BS, Travaglini EC, Loeb LA, Schultz J. Structure of Drosophila melanogaster dAT replicated in an in vitro system. Biochemical and Biophysical Research Communications. 40: 1266-72. PMID 4933684 DOI: 10.1016/0006-291X(70)90003-3  0.319
1971 Loeb LA, Slater JP, Ewald JL, Agarwal SS. In vitro DNA synthesis in the presence of antibody to homogeneous E. Coli DNA polymerase Biochemical and Biophysical Research Communications. 42: 147-153. PMID 4925952 DOI: 10.1016/0006-291X(71)90374-3  0.44
1971 Slater JP, Loeb LA. Initiation of DNA synthesis in eucaryotes: a model in vitro system. Biochemical and Biophysical Research Communications. 41: 589-93. PMID 4920869 DOI: 10.1016/0006-291X(70)90053-7  0.441
1970 Agarwal SS, Bugbee SJ, Loeb LA. Induction of DNA polymerase in mixed lymphocyte cultures Nature. 226: 949-950. PMID 5445878 DOI: 10.1038/226949A0  0.344
1969 Fansler B, Loeb LA. Sea urchin nuclear DNA polymerase. II. Changing localization during early development. Experimental Cell Research. 57: 305-10. PMID 5388418 DOI: 10.1016/0014-4827(69)90154-2  0.375
1969 Loeb LA, Fansler B, Williams R, Mazia D. Sea urchin nuclear DNA polymerase. I. Localization in nuclei during rapid DNA synthesis. Experimental Cell Research. 57: 298-304. PMID 5347633  0.642
1968 Loeb LA, Agarwal SS, Woodside AM. Induction of DNA polymerase in human lymphocytes by phytohemagglutinin Proceedings of the National Academy of Sciences of the United States of America. 61: 827-834. PMID 5246548 DOI: 10.1073/Pnas.61.3.827  0.432
1967 Loeb LA, Mazia D, Ruby AD. Priming of DNA polymerase in nuclei of sea urchin embryos by native DNA. Proceedings of the National Academy of Sciences of the United States of America. 57: 841-8. PMID 16591539 DOI: 10.1073/Pnas.57.3.841  0.645
1966 Kato R, Jondorf WR, Loeb LA, Ben T, Gelboin HV. Studies on the mechanism of drug-induced microsomal enzyme activities. V. Phenobarbital stimulation of endogenous messenger RNA and polyuridylic acid-directed L-[14C]-phenylalanine incorporation. Molecular Pharmacology. 2: 171-86. PMID 5905664  0.409
1964 LOEB LA, GELBOIN HV. METHYLCHOLANTHRENE-INDUCED CHANGES IN RAT LIVER NUCLEAR RNA. Proceedings of the National Academy of Sciences of the United States of America. 52: 1219-26. PMID 14231444 DOI: 10.1073/Pnas.52.5.1219  0.453
1963 LOEB LA, GELBOIN HV. STIMULATION OF AMINO-ACID INCORPORATION BY NUCLEAR RIBONUCLEIC ACID FROM NORMAL AND METHYLCHOLANTHRENE-TREATED RATS. Nature. 199: 809-10. PMID 14071196 DOI: 10.1038/199809A0  0.542
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